ATE509028T1 - Ionen-austausch-chromatographische trennung von glp-1 und verwandten peptiden - Google Patents

Ionen-austausch-chromatographische trennung von glp-1 und verwandten peptiden

Info

Publication number
ATE509028T1
ATE509028T1 AT00910570T AT00910570T ATE509028T1 AT E509028 T1 ATE509028 T1 AT E509028T1 AT 00910570 T AT00910570 T AT 00910570T AT 00910570 T AT00910570 T AT 00910570T AT E509028 T1 ATE509028 T1 AT E509028T1
Authority
AT
Austria
Prior art keywords
glp
ion exchange
chromatographic separation
related peptides
exchange chromatographic
Prior art date
Application number
AT00910570T
Other languages
English (en)
Inventor
Arne Staby
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE509028T1 publication Critical patent/ATE509028T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
AT00910570T 1999-03-15 2000-03-15 Ionen-austausch-chromatographische trennung von glp-1 und verwandten peptiden ATE509028T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA199900361 1999-03-15
DKPA200000082 2000-01-19
PCT/DK2000/000113 WO2000055203A1 (en) 1999-03-15 2000-03-15 Ion exchange chromatographic separation of glp-1 and related peptides

Publications (1)

Publication Number Publication Date
ATE509028T1 true ATE509028T1 (de) 2011-05-15

Family

ID=26063856

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00910570T ATE509028T1 (de) 1999-03-15 2000-03-15 Ionen-austausch-chromatographische trennung von glp-1 und verwandten peptiden

Country Status (5)

Country Link
EP (2) EP1163268B1 (de)
JP (1) JP4732590B2 (de)
AT (1) ATE509028T1 (de)
AU (1) AU3273200A (de)
WO (1) WO2000055203A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6444788B1 (en) 1999-03-15 2002-09-03 Novo Nordisk A/S Ion exchange chromatography of GLP-1, analogs and derivatives thereof
BRPI0413644A (pt) 2003-08-21 2006-10-17 Novo Nordisk As métodos para separar as duas formas de um polipeptìdeo tendo uma única racemização de aminoácido, e para separar dois polipeptìdeos, produto de polipeptìdeo, e, composição farmacêutica
WO2005019262A1 (en) * 2003-08-21 2005-03-03 Novo Nordisk A/S Purification of glucagon-like peptides
JP2008525381A (ja) 2004-12-23 2008-07-17 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 関心のあるビタミンｋ依存性タンパク質を含んでなる組成物中におけるタンパク質混入物の量の減少
CN102271775A (zh) * 2008-12-08 2011-12-07 诺沃-诺迪斯克有限公司 多肽的逆流提纯
AU2015252110A1 (en) * 2009-12-18 2015-11-26 Csl Limited Method of purifying polypeptides
EP3715356B1 (de) * 2009-12-18 2023-10-11 CSL Limited Verfahren zur aufreinigung von polypeptiden
US20110313131A1 (en) * 2010-06-21 2011-12-22 Christelle Carl Reversed phase hplc purification of a glp-1 analogue
CN104936610A (zh) * 2012-11-13 2015-09-23 益普生制药股份有限公司 Glp-1类似物的纯化方法
WO2014078729A1 (en) * 2012-11-15 2014-05-22 Genentech, Inc. IONIC STRENGTH-MEDIATED pH GRADIENT ION EXCHANGE CHROMATOGRAPHY
US10690635B2 (en) 2016-03-23 2020-06-23 Bachem Holding Ag Purification of glucagon-like peptide 1 analogs
CN110526982B (zh) * 2018-05-23 2023-08-01 信立泰(成都)生物技术有限公司 一种人胰高血糖素样肽-1类似物融合蛋白的纯化方法
CN109096363A (zh) * 2018-09-07 2018-12-28 苏州美极医疗科技有限公司 一种线性pH梯度缓冲液及其应用
CN113045640B (zh) * 2019-12-27 2023-03-24 翰宇药业（武汉）有限公司 一种glp-1类似物的纯化方法
KR20240034235A (ko) 2021-07-14 2024-03-13 베이징 큐엘 바이오파마슈티컬 컴퍼니 리미티드 대사 장애를 위한 융합 폴리펩타이드
CN113621046B (zh) * 2021-08-19 2022-05-27 重庆宸安生物制药有限公司 聚合物阴离子交换填料在制备利拉鲁肽中的用途和方法

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Publication number Priority date Publication date Assignee Title
US3907676A (en) * 1970-07-28 1975-09-23 Novo Terapeutisk Labor As Process for purifying insulin
US4318904A (en) 1980-04-25 1982-03-09 Research Corporation Peptide affinity labels for thrombin and other trypsin-like proteases
US4361510A (en) * 1980-05-27 1982-11-30 Cutter Laboratories, Inc. Blood coagulation promoting product
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
GR860984B (en) 1985-04-17 1986-08-18 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
CA1284000C (en) * 1985-07-01 1991-05-07 David Gregory Maskalick Process for recovering glucagon from pancreas glands
JP2583257B2 (ja) 1986-05-05 1997-02-19 ザ・ジェネラル・ホスピタル・コーポレーション インシュリン向性ホルモン
DE3726655A1 (de) * 1987-08-11 1989-02-23 Hoechst Ag Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten
ATE193541T1 (de) 1989-03-20 2000-06-15 Gen Hospital Corp Insulinotropes hormon
ATE164852T1 (de) 1990-01-24 1998-04-15 Douglas I Buckley Glp-1-analoga verwendbar in der diabetesbehandlung
WO1992015686A1 (en) 1991-02-28 1992-09-17 Zymogenetics, Inc. Modified factor vii
US5574008A (en) 1994-08-30 1996-11-12 Eli Lilly And Company Biologically active fragments of glucagon-like insulinotropic peptide
US5512549A (en) 1994-10-18 1996-04-30 Eli Lilly And Company Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
US5990077A (en) 1995-04-14 1999-11-23 1149336 Ontario Inc. Glucagon-like peptide-2 and its therapeutic use
JPH08337600A (ja) * 1995-06-13 1996-12-24 Ito Ham Kk グルカゴンの製造方法
JP4046377B2 (ja) * 1996-08-19 2008-02-13 財団法人化学及血清療法研究所 血液凝固第ｖｉｉ因子の活性化方法及び該方法に基づく活性化血液凝固第ｖｉｉ因子の製造方法
JPH1059866A (ja) * 1996-08-19 1998-03-03 Chemo Sero Therapeut Res Inst 血液凝固第ｖｉｉ因子及び／もしくは活性化血液凝固第ｖｉｉ因子の製造方法
JP3149958B2 (ja) * 1996-08-30 2001-03-26 ノボ ノルディスク アクティーゼルスカブ Ｇｌｐ―１誘導体
AU4112497A (en) * 1996-08-30 1998-03-19 Novo Nordisk A/S Glp-2 derivatives

Also Published As

Publication number Publication date
WO2000055203A1 (en) 2000-09-21
EP1163268B1 (de) 2011-05-11
AU3273200A (en) 2000-10-04
JP4732590B2 (ja) 2011-07-27
EP1163268A1 (de) 2001-12-19
EP2348044A1 (de) 2011-07-27
JP2002539219A (ja) 2002-11-19

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