FI883708A - Menetelmä emäksisten proteiinien eristämiseksi proteiiniseoksista, jotka sisältävät tällaisia emäksisiä proteiineja - Google Patents

Menetelmä emäksisten proteiinien eristämiseksi proteiiniseoksista, jotka sisältävät tällaisia emäksisiä proteiineja Download PDF

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Publication number
FI883708A
FI883708A FI883708A FI883708A FI883708A FI 883708 A FI883708 A FI 883708A FI 883708 A FI883708 A FI 883708A FI 883708 A FI883708 A FI 883708A FI 883708 A FI883708 A FI 883708A
Authority
FI
Finland
Prior art keywords
basic proteins
protein mixtures
mixtures containing
isolating
proteins
Prior art date
Application number
FI883708A
Other languages
English (en)
Swedish (sv)
Other versions
FI91875C (fi
FI91875B (fi
FI883708A0 (fi
Inventor
Michael Doerschug
Rainer Obermeier
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI883708A0 publication Critical patent/FI883708A0/fi
Publication of FI883708A publication Critical patent/FI883708A/fi
Application granted granted Critical
Publication of FI91875B publication Critical patent/FI91875B/fi
Publication of FI91875C publication Critical patent/FI91875C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI883708A 1987-08-11 1988-08-09 Menetelmä emäksisten proteiinien eristämiseksi proteiiniseoksista, jotka sisältävät tällaisia emäksisiä proteiineja FI91875C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19873726655 DE3726655A1 (de) 1987-08-11 1987-08-11 Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten
DE3726655 1987-08-11

Publications (4)

Publication Number Publication Date
FI883708A0 FI883708A0 (fi) 1988-08-09
FI883708A true FI883708A (fi) 1989-02-12
FI91875B FI91875B (fi) 1994-05-13
FI91875C FI91875C (fi) 1994-08-25

Family

ID=6333496

Family Applications (1)

Application Number Title Priority Date Filing Date
FI883708A FI91875C (fi) 1987-08-11 1988-08-09 Menetelmä emäksisten proteiinien eristämiseksi proteiiniseoksista, jotka sisältävät tällaisia emäksisiä proteiineja

Country Status (19)

Country Link
US (1) US5101013A (fi)
EP (1) EP0305760B1 (fi)
JP (1) JP2587867B2 (fi)
KR (1) KR0129539B1 (fi)
AT (1) ATE96447T1 (fi)
AU (1) AU609170B2 (fi)
CA (1) CA1340237C (fi)
DE (2) DE3726655A1 (fi)
DK (1) DK173502B1 (fi)
ES (1) ES2047007T3 (fi)
FI (1) FI91875C (fi)
HU (1) HU198218B (fi)
IE (1) IE61557B1 (fi)
IL (1) IL87385A (fi)
NO (1) NO175004C (fi)
NZ (1) NZ225746A (fi)
PH (1) PH26874A (fi)
PT (1) PT88230B (fi)
ZA (1) ZA885871B (fi)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0600372T3 (da) 1992-12-02 1997-08-11 Hoechst Ag Fremgangsmåde til fremstilling af proinsulin med korrekt forbundne cystinbroer.
DE59711533D1 (de) 1996-07-26 2004-05-27 Aventis Pharma Gmbh Insulinderivate mit erhöhter Zinkbindung
DE19652713C2 (de) * 1996-12-18 2001-11-22 Aventis Pharma Gmbh Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher
KR100341297B1 (ko) * 1997-03-29 2002-11-16 주식회사종근당 재조합활성형프로인슐린의분리.정제방법
DE19726167B4 (de) 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
ATE509028T1 (de) * 1999-03-15 2011-05-15 Novo Nordisk As Ionen-austausch-chromatographische trennung von glp-1 und verwandten peptiden
US6451987B1 (en) * 1999-03-15 2002-09-17 Novo Nordisk A/S Ion exchange chromatography of proteins and peptides
US6444788B1 (en) 1999-03-15 2002-09-03 Novo Nordisk A/S Ion exchange chromatography of GLP-1, analogs and derivatives thereof
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE10227232A1 (de) * 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
DE10235168A1 (de) * 2002-08-01 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Reinigung von Preproinsulin
US7193035B2 (en) * 2002-10-29 2007-03-20 Sanofi-Aventis Deutschland Gmbh Crystals of insulin analogs and processes for their preparation
SE0300791D0 (sv) * 2003-03-20 2003-03-20 Amersham Biosciences Ab Use of ph-responsive polymers
DE602004023626D1 (de) * 2003-08-21 2009-11-26 Novo Nordisk As Trennung von polypeptiden mit einer racemisierten aminosäure
WO2007015586A1 (ja) * 2005-08-04 2007-02-08 Toyo Seikan Kaisha, Ltd. プラスチックボトル殺菌方法
EP3228320B1 (de) 2008-10-17 2019-12-18 Sanofi-Aventis Deutschland GmbH Kombination von einem insulin und einem glp-1-agonisten
FR2947818B1 (fr) * 2009-07-09 2011-07-29 Inst Superieur Des Sciences Agronomiques Agroalimentaires Horticoles Et Du Paysage Agro Campus Ouest Utilisation d'un coproduit issu d'un procede d'extraction du lysozyme a partir de blanc d'oeuf, pour l'obtention d'au moins une proteine basique de blanc d'oeuf
UY33025A (es) 2009-11-13 2011-06-30 Sanofi Aventis Deustschland Gmbh Composicion farmaceutica que comprende un agonista de glp-1 metionina
AR080669A1 (es) 2009-11-13 2012-05-02 Sanofi Aventis Deutschland Composicion farmaceutica que comprende un agonista de glp-1, una insulina y metionina
MX339614B (es) 2010-08-30 2016-06-02 Sanofi - Aventis Deutschland GmbH Uso de ave0010 para la fabricacion de un medicamento para el tratamiento de la diabetes mellitus tipo 2.
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
RU2650616C2 (ru) 2011-08-29 2018-04-16 Санофи-Авентис Дойчланд Гмбх Фармацевтическая комбинация для применения при гликемическом контроле у пациентов с сахарным диабетом 2 типа
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
PL2748181T3 (pl) 2011-09-30 2016-08-31 Ge Healthcare Bioprocess R&D Ab Sposób oczyszczania rozszczepionej proinsuliny
EP2931301B2 (en) 2012-12-17 2021-09-15 Merck Sharp & Dohme Corp. Process for purifying insulin and analogues thereof
EP3116531B1 (en) 2014-03-14 2021-10-20 Merck Sharp & Dohme Corp. Purifying insulin using cation exchange and reverse phase chromatography in the presence of an organic modifier and elevated temperature
CN107206058A (zh) 2014-12-12 2017-09-26 赛诺菲-安万特德国有限公司 甘精胰岛素/利西拉来固定比率配制剂
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
JPWO2018147393A1 (ja) * 2017-02-10 2019-11-21 三菱ケミカル株式会社 ヒトインスリン精製用分離剤及びヒトインスリンの精製方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2629568C3 (de) * 1976-07-01 1981-09-10 Hoechst Ag, 6000 Frankfurt Verfahren zur Reinigung von Insulin, seinen Analogen und Derivaten
NL7713966A (nl) * 1976-12-27 1978-06-29 Univ Minnesota Werkwijze voor het behandelen van insuline.
DK311477A (da) * 1977-07-08 1979-01-09 Leo Lab Fremgangsmaade ved fremstilling af rent insulin
US4459226A (en) * 1982-02-26 1984-07-10 Eli Lilly And Company Process for recovering insulin
DD247684A1 (de) * 1983-04-14 1987-07-15 Ulrich Krabiell Verfahren zur isolierung von insulinderivaten
ATE95236T1 (de) * 1983-04-25 1993-10-15 Chiron Corp Hybrid-dns-synthesis von reifen insulinaehnlichen wachstumsfaktoren.
DE3440988A1 (de) * 1984-11-09 1986-07-10 Hoechst Ag, 6230 Frankfurt Verfahren zur spaltung von peptiden und proteinen an der methionyl-bindung
DE3511269A1 (de) * 1985-04-12 1986-10-09 Veb Berlin-Chemie, Ddr 1199 Berlin Verfahren zur reinigung von insulin
JPS6379591A (ja) * 1986-09-22 1988-04-09 Mitsui Toatsu Chem Inc ｔＰＡの精製方法
AU607988B2 (en) * 1987-04-21 1991-03-21 Southern Cross Biotech Pty Ltd. Production of proteins in active forms
DE68919647T2 (de) * 1988-10-26 1995-05-11 American Cyanamid Co Verfahren zur Verringerung des Aggregatinhaltes in Wachstumshormonen gleichenden Stoffen.

Also Published As

Publication number Publication date
PT88230B (pt) 1995-03-01
FI91875C (fi) 1994-08-25
DK447688A (da) 1989-02-12
ES2047007T3 (es) 1994-02-16
HU198218B (en) 1989-08-28
HUT47958A (en) 1989-04-28
IL87385A (en) 1993-08-18
KR0129539B1 (ko) 1998-04-04
FI91875B (fi) 1994-05-13
NZ225746A (en) 1990-11-27
IE882441L (en) 1989-02-11
IL87385A0 (en) 1989-01-31
EP0305760A3 (en) 1990-06-06
DK173502B1 (da) 2001-01-08
NO883554D0 (no) 1988-08-10
ATE96447T1 (de) 1993-11-15
CA1340237C (en) 1998-12-15
NO175004C (no) 1994-08-17
IE61557B1 (en) 1994-11-16
EP0305760B1 (de) 1993-10-27
AU2059188A (en) 1989-02-16
DE3885214D1 (de) 1993-12-02
US5101013A (en) 1992-03-31
KR890003799A (ko) 1989-04-18
PT88230A (pt) 1989-06-30
NO175004B (no) 1994-05-09
JPS6486896A (en) 1989-03-31
DE3726655A1 (de) 1989-02-23
ZA885871B (en) 1989-04-26
PH26874A (en) 1992-11-16
NO883554L (no) 1989-02-13
JP2587867B2 (ja) 1997-03-05
FI883708A0 (fi) 1988-08-09
AU609170B2 (en) 1991-04-26
DK447688D0 (da) 1988-08-10
EP0305760A2 (de) 1989-03-08

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Owner name: AVENTIS PHARMA DEUTSCHLAND GMBH

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Free format text: SANOFI-AVENTIS DEUTSCHLAND GMBH

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