FI883708A - Menetelmä emäksisten proteiinien eristämiseksi proteiiniseoksista, jotka sisältävät tällaisia emäksisiä proteiineja - Google Patents
Menetelmä emäksisten proteiinien eristämiseksi proteiiniseoksista, jotka sisältävät tällaisia emäksisiä proteiineja Download PDFInfo
- Publication number
- FI883708A FI883708A FI883708A FI883708A FI883708A FI 883708 A FI883708 A FI 883708A FI 883708 A FI883708 A FI 883708A FI 883708 A FI883708 A FI 883708A FI 883708 A FI883708 A FI 883708A
- Authority
- FI
- Finland
- Prior art keywords
- basic proteins
- protein mixtures
- mixtures containing
- isolating
- proteins
- Prior art date
Links
- 101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108010076181 Proinsulin Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 238000010353 genetic engineering Methods 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19873726655 DE3726655A1 (de) | 1987-08-11 | 1987-08-11 | Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten |
DE3726655 | 1987-08-11 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI883708A0 FI883708A0 (fi) | 1988-08-09 |
FI883708A true FI883708A (fi) | 1989-02-12 |
FI91875B FI91875B (fi) | 1994-05-13 |
FI91875C FI91875C (fi) | 1994-08-25 |
Family
ID=6333496
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI883708A FI91875C (fi) | 1987-08-11 | 1988-08-09 | Menetelmä emäksisten proteiinien eristämiseksi proteiiniseoksista, jotka sisältävät tällaisia emäksisiä proteiineja |
Country Status (19)
Country | Link |
---|---|
US (1) | US5101013A (fi) |
EP (1) | EP0305760B1 (fi) |
JP (1) | JP2587867B2 (fi) |
KR (1) | KR0129539B1 (fi) |
AT (1) | ATE96447T1 (fi) |
AU (1) | AU609170B2 (fi) |
CA (1) | CA1340237C (fi) |
DE (2) | DE3726655A1 (fi) |
DK (1) | DK173502B1 (fi) |
ES (1) | ES2047007T3 (fi) |
FI (1) | FI91875C (fi) |
HU (1) | HU198218B (fi) |
IE (1) | IE61557B1 (fi) |
IL (1) | IL87385A (fi) |
NO (1) | NO175004C (fi) |
NZ (1) | NZ225746A (fi) |
PH (1) | PH26874A (fi) |
PT (1) | PT88230B (fi) |
ZA (1) | ZA885871B (fi) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0600372B1 (de) * | 1992-12-02 | 1997-02-05 | Hoechst Aktiengesellschaft | Verfahren zur Gewinnung von Proinsulin mit korrekt verbundenen Cystinbrücken |
ES2218622T3 (es) | 1996-07-26 | 2004-11-16 | Aventis Pharma Deutschland Gmbh | Derivados de insulina con actividad de union al zinc incrementada. |
DE19652713C2 (de) * | 1996-12-18 | 2001-11-22 | Aventis Pharma Gmbh | Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher |
KR100341297B1 (ko) * | 1997-03-29 | 2002-11-16 | 주식회사종근당 | 재조합활성형프로인슐린의분리.정제방법 |
DE19726167B4 (de) | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
DE19825447A1 (de) | 1998-06-06 | 1999-12-09 | Hoechst Marion Roussel De Gmbh | Neue Insulinanaloga mit erhöhter Zinkbildung |
US6451987B1 (en) * | 1999-03-15 | 2002-09-17 | Novo Nordisk A/S | Ion exchange chromatography of proteins and peptides |
EP2348044A1 (en) * | 1999-03-15 | 2011-07-27 | Novo Nordisk A/S | Ion exchange chromatography of GLP-1, analogs and derivatives thereof |
US6444788B1 (en) | 1999-03-15 | 2002-09-03 | Novo Nordisk A/S | Ion exchange chromatography of GLP-1, analogs and derivatives thereof |
DE10114178A1 (de) | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
DE10227232A1 (de) * | 2002-06-18 | 2004-01-15 | Aventis Pharma Deutschland Gmbh | Saure Insulinzubereitungen mit verbesserter Stabilität |
DE10235168A1 (de) * | 2002-08-01 | 2004-02-12 | Aventis Pharma Deutschland Gmbh | Verfahren zur Reinigung von Preproinsulin |
US7193035B2 (en) * | 2002-10-29 | 2007-03-20 | Sanofi-Aventis Deutschland Gmbh | Crystals of insulin analogs and processes for their preparation |
SE0300791D0 (sv) * | 2003-03-20 | 2003-03-20 | Amersham Biosciences Ab | Use of ph-responsive polymers |
CA2532340A1 (en) * | 2003-08-21 | 2005-03-03 | Novo Nordisk A/S | Separation of polypeptides comprising a racemized amino acid |
KR101039353B1 (ko) * | 2005-08-04 | 2011-06-08 | 도요 세이칸 가부시키가이샤 | 플라스틱 보틀 살균 방법 |
HUE037449T2 (hu) | 2008-10-17 | 2018-08-28 | Sanofi Aventis Deutschland | Egy inzulin és egy GLP-1 agonista kombinációja |
FR2947818B1 (fr) * | 2009-07-09 | 2011-07-29 | Inst Superieur Des Sciences Agronomiques Agroalimentaires Horticoles Et Du Paysage Agro Campus Ouest | Utilisation d'un coproduit issu d'un procede d'extraction du lysozyme a partir de blanc d'oeuf, pour l'obtention d'au moins une proteine basique de blanc d'oeuf |
PE20121316A1 (es) | 2009-11-13 | 2012-10-05 | Sanofi Aventis Deutschland | Composicion farmaceutica que comprende un agonista de glp-1 y metionina |
RU2537239C2 (ru) | 2009-11-13 | 2014-12-27 | Санофи-Авентис Дойчланд Гмбх | Фармацевтическая композиция, включающая агонист glp-1, инсулин и метионин |
PT2611458T (pt) | 2010-08-30 | 2016-12-16 | Sanofi Aventis Deutschland | Utilização de ave0010 para o fabrico de um medicamento para o tratamento da diabetes mellitus tipo 2 |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
PT2750699E (pt) | 2011-08-29 | 2015-11-03 | Sanofi Aventis Deutschland | Acelerómetro pendular |
TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
PL2748181T3 (pl) | 2011-09-30 | 2016-08-31 | Ge Healthcare Bioprocess R&D Ab | Sposób oczyszczania rozszczepionej proinsuliny |
EP2931301B2 (en) | 2012-12-17 | 2021-09-15 | Merck Sharp & Dohme Corp. | Process for purifying insulin and analogues thereof |
US10407483B2 (en) | 2014-03-14 | 2019-09-10 | Merck Sharp & Dohme Corp. | Purifying insulin using cation exchange and reverse phase chromatography in the presence of an organic modifier and elevated temperature |
CA2970200A1 (en) | 2014-12-12 | 2016-06-16 | Sanofi-Aventis Deutschland Gmbh | Insulin glargine/lixisenatide fixed ratio formulation |
TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患之治療 |
JPWO2018147393A1 (ja) * | 2017-02-10 | 2019-11-21 | 三菱ケミカル株式会社 | ヒトインスリン精製用分離剤及びヒトインスリンの精製方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2629568C3 (de) * | 1976-07-01 | 1981-09-10 | Hoechst Ag, 6000 Frankfurt | Verfahren zur Reinigung von Insulin, seinen Analogen und Derivaten |
NL7713966A (nl) * | 1976-12-27 | 1978-06-29 | Univ Minnesota | Werkwijze voor het behandelen van insuline. |
DK311477A (da) * | 1977-07-08 | 1979-01-09 | Leo Lab | Fremgangsmaade ved fremstilling af rent insulin |
US4459226A (en) * | 1982-02-26 | 1984-07-10 | Eli Lilly And Company | Process for recovering insulin |
DD247684A1 (de) * | 1983-04-14 | 1987-07-15 | Ulrich Krabiell | Verfahren zur isolierung von insulinderivaten |
EP0123228B1 (en) * | 1983-04-25 | 1993-09-29 | Chiron Corporation | Hybrid dna synthesis of mature insulin-like growth factors |
DE3440988A1 (de) * | 1984-11-09 | 1986-07-10 | Hoechst Ag, 6230 Frankfurt | Verfahren zur spaltung von peptiden und proteinen an der methionyl-bindung |
DE3511269A1 (de) * | 1985-04-12 | 1986-10-09 | Veb Berlin-Chemie, Ddr 1199 Berlin | Verfahren zur reinigung von insulin |
JPS6379591A (ja) * | 1986-09-22 | 1988-04-09 | Mitsui Toatsu Chem Inc | tPAの精製方法 |
AU607988B2 (en) * | 1987-04-21 | 1991-03-21 | Southern Cross Biotech Pty Ltd. | Production of proteins in active forms |
EP0365858B1 (en) * | 1988-10-26 | 1994-11-30 | American Cyanamid Company | Process for reducing the aggregate content of growth hormone-like materials |
-
1987
- 1987-08-11 DE DE19873726655 patent/DE3726655A1/de not_active Withdrawn
-
1988
- 1988-08-04 ES ES88112661T patent/ES2047007T3/es not_active Expired - Lifetime
- 1988-08-04 AT AT88112661T patent/ATE96447T1/de not_active IP Right Cessation
- 1988-08-04 DE DE88112661T patent/DE3885214D1/de not_active Expired - Lifetime
- 1988-08-04 EP EP88112661A patent/EP0305760B1/de not_active Expired - Lifetime
- 1988-08-09 PH PH37374A patent/PH26874A/en unknown
- 1988-08-09 FI FI883708A patent/FI91875C/fi not_active IP Right Cessation
- 1988-08-09 HU HU884131A patent/HU198218B/hu unknown
- 1988-08-09 IL IL87385A patent/IL87385A/xx not_active IP Right Cessation
- 1988-08-09 KR KR1019880010123A patent/KR0129539B1/ko not_active IP Right Cessation
- 1988-08-09 NZ NZ225746A patent/NZ225746A/en unknown
- 1988-08-09 US US07/230,085 patent/US5101013A/en not_active Expired - Lifetime
- 1988-08-10 NO NO883554A patent/NO175004C/no not_active IP Right Cessation
- 1988-08-10 CA CA000574320A patent/CA1340237C/en not_active Expired - Lifetime
- 1988-08-10 IE IE244188A patent/IE61557B1/en not_active IP Right Cessation
- 1988-08-10 AU AU20591/88A patent/AU609170B2/en not_active Expired
- 1988-08-10 PT PT88230A patent/PT88230B/pt not_active IP Right Cessation
- 1988-08-10 ZA ZA885871A patent/ZA885871B/xx unknown
- 1988-08-10 DK DK198804476A patent/DK173502B1/da not_active IP Right Cessation
- 1988-08-10 JP JP63198127A patent/JP2587867B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
NZ225746A (en) | 1990-11-27 |
JPS6486896A (en) | 1989-03-31 |
NO883554D0 (no) | 1988-08-10 |
AU609170B2 (en) | 1991-04-26 |
NO175004C (no) | 1994-08-17 |
IL87385A0 (en) | 1989-01-31 |
DK447688A (da) | 1989-02-12 |
HU198218B (en) | 1989-08-28 |
CA1340237C (en) | 1998-12-15 |
FI91875B (fi) | 1994-05-13 |
FI91875C (fi) | 1994-08-25 |
HUT47958A (en) | 1989-04-28 |
KR0129539B1 (ko) | 1998-04-04 |
NO175004B (no) | 1994-05-09 |
ATE96447T1 (de) | 1993-11-15 |
EP0305760B1 (de) | 1993-10-27 |
ZA885871B (en) | 1989-04-26 |
EP0305760A2 (de) | 1989-03-08 |
IE882441L (en) | 1989-02-11 |
PT88230A (pt) | 1989-06-30 |
DK447688D0 (da) | 1988-08-10 |
PH26874A (en) | 1992-11-16 |
DE3885214D1 (de) | 1993-12-02 |
IE61557B1 (en) | 1994-11-16 |
DK173502B1 (da) | 2001-01-08 |
EP0305760A3 (en) | 1990-06-06 |
AU2059188A (en) | 1989-02-16 |
PT88230B (pt) | 1995-03-01 |
FI883708A0 (fi) | 1988-08-09 |
IL87385A (en) | 1993-08-18 |
ES2047007T3 (es) | 1994-02-16 |
KR890003799A (ko) | 1989-04-18 |
DE3726655A1 (de) | 1989-02-23 |
NO883554L (no) | 1989-02-13 |
US5101013A (en) | 1992-03-31 |
JP2587867B2 (ja) | 1997-03-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
BB | Publication of examined application | ||
FG | Patent granted |
Owner name: AVENTIS PHARMA DEUTSCHLAND GMBH |
|
PC | Transfer of assignment of patent |
Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH Free format text: SANOFI-AVENTIS DEUTSCHLAND GMBH |
|
MA | Patent expired |