HUP0000191A2 - Farnezil-protein-transzferáz inhibitorként alkalmazható új triciklusos piperidinil-vegyületek - Google Patents

Farnezil-protein-transzferáz inhibitorként alkalmazható új triciklusos piperidinil-vegyületek

Info

Publication number
HUP0000191A2
HUP0000191A2 HU0000191A HUP0000191A HUP0000191A2 HU P0000191 A2 HUP0000191 A2 HU P0000191A2 HU 0000191 A HU0000191 A HU 0000191A HU P0000191 A HUP0000191 A HU P0000191A HU P0000191 A2 HUP0000191 A2 HU P0000191A2
Authority
HU
Hungary
Prior art keywords
protein transferase
group
farnesyl
inhibitors
hydrogen
Prior art date
Application number
HU0000191A
Other languages
English (en)
Inventor
John J. Baldwin
Alan B. Cooler
Ronald J. Doll
Viyyoor M. Girijavallabhan
Alan K. Mallans
George Njoroge F.
John C. Reader
Arthur G. Taveras
Original Assignee
Schering Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp. filed Critical Schering Corp.
Publication of HUP0000191A2 publication Critical patent/HUP0000191A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

A találmány tárgyát (1.0) általános képletű, farnezil-protein-transzferáz-inhibitor hatású, új, triciklusos vegyületek - aholelőnyösen a nitrogénatom, b, c és d metincsoport; R1, R2, R3 és R4 egymástól függetlenül hidrogén- vagy halogénatom; R5, R6, R7 és R8 hidrogénatom; A és B az 5-ös és 6-os szénatom közötti egyszeres vagy kettős kötéstőlfüggően egy-egy vagy két-két hidrogénatom; T karbonilcsoport; Z -NR40R42 általános képletű csoport, amelyben R40 hidrogénatom és R42heteroaril-alkil-, előnyösen 3-piridil-metil-csoport; és n értéke 0-6, előnyösen 0 -, a farnezil-protein-transzferáz gátlására,valamint daganatos betegségek kezelésére való alkalmazásuk és ezekettartalmazó gyógyszerkészítmények képezik. Ó
HU0000191A 1996-09-13 1997-09-11 Farnezil-protein-transzferáz inhibitorként alkalmazható új triciklusos piperidinil-vegyületek HUP0000191A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71370396A 1996-09-13 1996-09-13
PCT/US1997/015903 WO1998011098A1 (en) 1996-09-13 1997-09-11 Novel tricyclic piperidinyl compounds useful as inhibitors of farnesyl-protein transferase

Publications (1)

Publication Number Publication Date
HUP0000191A2 true HUP0000191A2 (hu) 2001-04-28

Family

ID=24867181

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0000191A HUP0000191A2 (hu) 1996-09-13 1997-09-11 Farnezil-protein-transzferáz inhibitorként alkalmazható új triciklusos piperidinil-vegyületek

Country Status (19)

Country Link
EP (1) EP0931078B1 (hu)
JP (1) JP2001500507A (hu)
KR (1) KR20000036104A (hu)
CN (1) CN1237170A (hu)
AT (1) ATE345338T1 (hu)
AU (1) AU4337697A (hu)
BR (1) BR9712826A (hu)
CA (1) CA2265763A1 (hu)
CZ (1) CZ84199A3 (hu)
DE (1) DE69736950T2 (hu)
ES (1) ES2276435T3 (hu)
HU (1) HUP0000191A2 (hu)
ID (1) ID21218A (hu)
NO (1) NO991233L (hu)
NZ (1) NZ334452A (hu)
PL (1) PL332241A1 (hu)
SK (1) SK33099A3 (hu)
TR (1) TR199901274T2 (hu)
WO (1) WO1998011098A1 (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6509346B2 (en) 1998-01-21 2003-01-21 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
DE69928226T8 (de) 1998-01-21 2006-10-19 Millennium Pharmaceuticals, Inc., Cambridge Chemokin rezeptor antagonisten und verwendung
US6613905B1 (en) 1998-01-21 2003-09-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
EP1047675A1 (en) 1998-01-21 2000-11-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US7271176B2 (en) 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
US6503926B2 (en) 1998-09-04 2003-01-07 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6288083B1 (en) 1998-09-04 2001-09-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6645966B2 (en) 2001-01-22 2003-11-11 Schering Corporation Treatment of malaria with farnesyl protein transferase inhibitors
WO2002080895A2 (en) * 2001-04-06 2002-10-17 Schering Corporation Treatment of malaria with farsenyl protein transferase inhibitors
US7541365B2 (en) 2001-11-21 2009-06-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
TWI291467B (en) 2002-11-13 2007-12-21 Millennium Pharm Inc CCR1 antagonists and methods of use therefor
EP1758580A4 (en) * 2004-06-24 2008-01-16 Incyte Corp N-SUBSTITUTED PIPERIDINE AND ITS USE AS A MEDICAMENT
CA2663044C (en) * 2006-10-06 2012-07-24 Bausch & Lomb Incorporated Quinolone carboxylic acids, derivatives thereof, and methods of making and using same
US7632944B2 (en) * 2007-01-24 2009-12-15 Bausch & Lomb Incorporated Quinolone carboxylic acids, derivatives thereof, and methods of making and using same
US20110136790A1 (en) * 2008-07-23 2011-06-09 De Lera Ruiz Manuel Tricyclic Heterocyclic Derivatives and Methods of Use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1593417A (en) * 1976-12-22 1981-07-15 Squibb & Sons Inc Carbocyclic-fused pyrazolopyridine derivatives
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
IL98572A (en) * 1990-06-22 1995-07-31 Schering Corp Bite-benzo or benzopyrido compounds Cyclohepta piperidine, piperidylidene and piperazine, preparations and methods of use.
DK0723538T3 (da) * 1993-10-15 2002-03-18 Schering Corp Tricykliske carbamatforbindelser, der er nyttige til inhibition af funktion af G-protein og til behandling af proliferative sygdomme
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them

Also Published As

Publication number Publication date
EP0931078A1 (en) 1999-07-28
WO1998011098A1 (en) 1998-03-19
PL332241A1 (en) 1999-08-30
CA2265763A1 (en) 1998-03-19
DE69736950D1 (de) 2006-12-28
ES2276435T3 (es) 2007-06-16
DE69736950T2 (de) 2007-09-20
CN1237170A (zh) 1999-12-01
CZ84199A3 (cs) 1999-11-17
ID21218A (id) 1999-05-06
NO991233L (no) 1999-05-12
ATE345338T1 (de) 2006-12-15
NO991233D0 (no) 1999-03-12
KR20000036104A (ko) 2000-06-26
JP2001500507A (ja) 2001-01-16
NZ334452A (en) 2000-09-29
SK33099A3 (en) 2000-05-16
AU4337697A (en) 1998-04-02
BR9712826A (pt) 1999-11-16
EP0931078B1 (en) 2006-11-15
TR199901274T2 (xx) 1999-10-21

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