BR9712826A - Novos compostos de piperidinila tricìclica úteis como inibidores de transferase de proteìna farnesil - Google Patents
Novos compostos de piperidinila tricìclica úteis como inibidores de transferase de proteìna farnesilInfo
- Publication number
- BR9712826A BR9712826A BR9712826-0A BR9712826A BR9712826A BR 9712826 A BR9712826 A BR 9712826A BR 9712826 A BR9712826 A BR 9712826A BR 9712826 A BR9712826 A BR 9712826A
- Authority
- BR
- Brazil
- Prior art keywords
- protein transferase
- compounds useful
- new
- new tricyclic
- farnesyl protein
- Prior art date
Links
- 125000003386 piperidinyl group Chemical group 0.000 title 1
- 239000003528 protein farnesyltransferase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000002159 abnormal effect Effects 0.000 abstract 2
- 230000010261 cell growth Effects 0.000 abstract 2
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 102000004357 Transferases Human genes 0.000 abstract 1
- 108090000992 Transferases Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000002532 enzyme inhibitor Substances 0.000 abstract 1
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 239000003558 transferase inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Patente de Invenção: <B>"NOVOS COMPOSTOS DE PIPERIDINILA TRICìCLICA úTEIS COMO INIBIDORES DE TRANSFERASE DE PROTEìNA FARNESIL"<D>. Novos compostos tricíclicos de fórmula (1.0) ou um sal ou solvato farmaceuticamente aceitável do mesmo, onde: um de a, b, c e d representa N opu NR^ 9^ onde R^ 9^ é O^ -^, -CH~ 3~ ou -(CH~ 2~)~ n~CO~ 2~H onde n varia de 1 a 3, e os grupos a, b, c e d restantes representam CR^ 1^ ou CR^ 2^; ou cada um de a, b, c e d é independentemente selecionado de CR^ 1^ ou CR^ 2^; cada R^ 1^ e cada R^ 2^ é independentemente selecionado de H, halo, -CR~ 3~, -OR^ 10^, -COR^ 10^, -SR^ 10^, -S(O)~ t~R^ 11^(onde t é 0, 1 ou 2), -SCN, -N(^ 10^R^ 11^, -CO(O)R^ 10^, -CO~ 2~R^ 10^, -OCO~ 2~R^ 11^, -CN, -NHC(O)R^ 10^, -CONHR^ 10^, -CONHCH~ 2~CH~ 2~OH, -NR^ 10^COOR^ 11^C(O)OR^ 11^, -SR^ 11^N(R^ 75^)~ 2~; n é 0 (zero), 1, 2, 3, 4, 5 ou 6; T é -CO-, -SO-, -SO~ 2~- ou -CR^ 30^R^ 31^-; Z representa alquila, arila, aralquila, heteroalquila, heteroalquila, heterocicloalquila, heterocicloalquialquila, -OR^ 40^, -SR^ 40^, -CR^ 40^R^ 42^, -NR^ 40^R^ 42^, as fórmula (i), (ii), (iii), (iv), (v) e (vi). São apresentadas composições farmacêuticas que são inibidores da enzima, transferase de proteína farnesil. Também é apresentado um método para inibir a função de Ras e portanto inibir o crescimento anormal de células. O método compreende administrar o novo composto tricíclico e um sistema biológico. Em particular, o método inibe o cresicimento anormal de células em um mamífero tal como o homem.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71370396A | 1996-09-13 | 1996-09-13 | |
| PCT/US1997/015903 WO1998011098A1 (en) | 1996-09-13 | 1997-09-11 | Novel tricyclic piperidinyl compounds useful as inhibitors of farnesyl-protein transferase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9712826A true BR9712826A (pt) | 1999-11-16 |
Family
ID=24867181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9712826-0A BR9712826A (pt) | 1996-09-13 | 1997-09-11 | Novos compostos de piperidinila tricìclica úteis como inibidores de transferase de proteìna farnesil |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0931078B1 (pt) |
| JP (1) | JP2001500507A (pt) |
| KR (1) | KR20000036104A (pt) |
| CN (1) | CN1237170A (pt) |
| AT (1) | ATE345338T1 (pt) |
| AU (1) | AU4337697A (pt) |
| BR (1) | BR9712826A (pt) |
| CA (1) | CA2265763A1 (pt) |
| CZ (1) | CZ84199A3 (pt) |
| DE (1) | DE69736950T2 (pt) |
| ES (1) | ES2276435T3 (pt) |
| HU (1) | HUP0000191A2 (pt) |
| ID (1) | ID21218A (pt) |
| NO (1) | NO991233L (pt) |
| NZ (1) | NZ334452A (pt) |
| PL (1) | PL332241A1 (pt) |
| SK (1) | SK33099A3 (pt) |
| TR (1) | TR199901274T2 (pt) |
| WO (1) | WO1998011098A1 (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6509346B2 (en) | 1998-01-21 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6613905B1 (en) | 1998-01-21 | 2003-09-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| ATE309249T1 (de) | 1998-01-21 | 2005-11-15 | Millennium Pharm Inc | Chemokin rezeptor antagonisten und verwndung |
| US6433165B1 (en) | 1998-01-21 | 2002-08-13 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6288083B1 (en) | 1998-09-04 | 2001-09-11 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US7271176B2 (en) | 1998-09-04 | 2007-09-18 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
| US6503926B2 (en) | 1998-09-04 | 2003-01-07 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| AU2002236813A1 (en) | 2001-01-22 | 2002-07-30 | Schering Corporation | Treatment of malaria with farnesyl protein transferase inhibitors |
| AU2002257114A1 (en) * | 2001-04-06 | 2002-10-21 | Schering Corporation | Treatment of malaria with farsenyl protein transferase inhibitors |
| US7541365B2 (en) | 2001-11-21 | 2009-06-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| TWI291467B (en) | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
| NZ551603A (en) * | 2004-06-24 | 2010-11-26 | Incyte Corp | N-substituted piperidines and their use as pharmaceuticals |
| BRPI0717513A2 (pt) * | 2006-10-06 | 2013-11-19 | Bausch & Lomb | Processo para preparar um composto, enantiômero isolado de uma fluoroquinolona, uso do enantiômero isolado, e, composição oftálmica |
| US7632944B2 (en) * | 2007-01-24 | 2009-12-15 | Bausch & Lomb Incorporated | Quinolone carboxylic acids, derivatives thereof, and methods of making and using same |
| US20110136790A1 (en) * | 2008-07-23 | 2011-06-09 | De Lera Ruiz Manuel | Tricyclic Heterocyclic Derivatives and Methods of Use |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1593417A (en) * | 1976-12-22 | 1981-07-15 | Squibb & Sons Inc | Carbocyclic-fused pyrazolopyridine derivatives |
| US5089496A (en) * | 1986-10-31 | 1992-02-18 | Schering Corporation | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies |
| IE68935B1 (en) * | 1990-06-22 | 1996-07-24 | Schering Corp | Bis-benzo or benzopyrido cyclohepta piperidene piperidylidene and piperazine compounds compositions and methods of use |
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
| CA2174105C (en) * | 1993-10-15 | 2002-02-12 | W. Robert Bishop | Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
-
1997
- 1997-09-11 NZ NZ334452A patent/NZ334452A/xx unknown
- 1997-09-11 AU AU43376/97A patent/AU4337697A/en not_active Abandoned
- 1997-09-11 JP JP10513762A patent/JP2001500507A/ja not_active Ceased
- 1997-09-11 ID IDW990091A patent/ID21218A/id unknown
- 1997-09-11 BR BR9712826-0A patent/BR9712826A/pt unknown
- 1997-09-11 CA CA002265763A patent/CA2265763A1/en not_active Abandoned
- 1997-09-11 PL PL97332241A patent/PL332241A1/xx unknown
- 1997-09-11 SK SK330-99A patent/SK33099A3/sk unknown
- 1997-09-11 TR TR1999/01274T patent/TR199901274T2/xx unknown
- 1997-09-11 AT AT97941477T patent/ATE345338T1/de not_active IP Right Cessation
- 1997-09-11 CN CN97199599A patent/CN1237170A/zh active Pending
- 1997-09-11 HU HU0000191A patent/HUP0000191A2/hu unknown
- 1997-09-11 DE DE69736950T patent/DE69736950T2/de not_active Expired - Fee Related
- 1997-09-11 EP EP97941477A patent/EP0931078B1/en not_active Expired - Lifetime
- 1997-09-11 WO PCT/US1997/015903 patent/WO1998011098A1/en active IP Right Grant
- 1997-09-11 KR KR1019997002127A patent/KR20000036104A/ko not_active Application Discontinuation
- 1997-09-11 ES ES97941477T patent/ES2276435T3/es not_active Expired - Lifetime
- 1997-09-11 CZ CZ99841A patent/CZ84199A3/cs unknown
-
1999
- 1999-03-12 NO NO991233A patent/NO991233L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE345338T1 (de) | 2006-12-15 |
| WO1998011098A1 (en) | 1998-03-19 |
| DE69736950T2 (de) | 2007-09-20 |
| ES2276435T3 (es) | 2007-06-16 |
| KR20000036104A (ko) | 2000-06-26 |
| ID21218A (id) | 1999-05-06 |
| NZ334452A (en) | 2000-09-29 |
| AU4337697A (en) | 1998-04-02 |
| EP0931078A1 (en) | 1999-07-28 |
| NO991233L (no) | 1999-05-12 |
| NO991233D0 (no) | 1999-03-12 |
| CZ84199A3 (cs) | 1999-11-17 |
| SK33099A3 (en) | 2000-05-16 |
| EP0931078B1 (en) | 2006-11-15 |
| HUP0000191A2 (hu) | 2001-04-28 |
| CN1237170A (zh) | 1999-12-01 |
| CA2265763A1 (en) | 1998-03-19 |
| TR199901274T2 (xx) | 1999-10-21 |
| PL332241A1 (en) | 1999-08-30 |
| JP2001500507A (ja) | 2001-01-16 |
| DE69736950D1 (de) | 2006-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |