CN1220613A - 医疗用弹力分送装置 - Google Patents

医疗用弹力分送装置 Download PDF

Info

Publication number
CN1220613A
CN1220613A CN97195179A CN97195179A CN1220613A CN 1220613 A CN1220613 A CN 1220613A CN 97195179 A CN97195179 A CN 97195179A CN 97195179 A CN97195179 A CN 97195179A CN 1220613 A CN1220613 A CN 1220613A
Authority
CN
China
Prior art keywords
mentioned
locking device
spring
dispensing member
primary importance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN97195179A
Other languages
English (en)
Inventor
T·E·维斯顿
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Weston Medical Ltd
Original Assignee
Weston Medical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Weston Medical Ltd filed Critical Weston Medical Ltd
Publication of CN1220613A publication Critical patent/CN1220613A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A61M2005/2013—Having specific accessories triggering of discharging means by contact of injector with patient body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
    • A61M2005/3118—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula
    • A61M2005/312—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula comprising sealing means, e.g. severable caps, to be removed prior to injection by, e.g. tearing or twisting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum

Abstract

一种分送装置,譬如无针头注射器,它包括提供能量储存的弹簧,和可移动分送构件,以在弹簧力的作用下有效的输送。一锁定块,具有第一位置,在该位置它限制分送构件的运动,以及第二位置,在该位置它允许这种运动。一个由使用者操作的触发装置,它可将锁定块从第一位置移动到第二位置。一个安全装置是在分送构件内适当形状的槽,它在本装置被安装完毕前有效的阻止锁定块移动到第二位置。

Description

医疗用弹力分送装置
本发明与分送装置有关，它用弹簧推动分送构件输送一剂量的液体，粉未或颗粒之类的药剂。该弹簧，例如，可以是机械弹簧，如金属簧；或是压缩气体弹簧，如压缩空气。
这种分送装置的一个实例是无针头注射器。尤其是，不同类型的无针头注射器在国际专利公布第WO93/03779和WO95/03844号中有描述；它们均以本申请人的名义发表。本发明将参考无针头注射器进行详细描述，但是应理解，它同样适用于其它类型的弹力分送装置。
在上述国际专利公布中描述的那类弹力无针头位射器，在使用之前，其弹簧在分送构件上持续施加一个力，同时，为阻止分送构件在弹簧力作用下的移动，提供一种限制装置。实际上，无针头注射器的注射动作是推动注射器进入一种状态，在该状态下该限制装置不再具有限制效力，从而允许分送构件的移动。
但是，组装这种装置存在一个潜在问题，如果这种装置容易被使用者操作的话，它就容易，或至少可能在制造过程中这种装置会意外地被发射。这不仅是不经济的，同时也对有关人员的安全造成危害。本发明的目的就是提供克服这个问题的装置。
根据本发明，所提供的分送或送物品的装置包括弹簧，它提供能量储存；一个可移动的分送构件，以在弹簧力的作用下有效地输送；锁定装置，它具有第一位置，在该位置，它阻止分送构件的运动，以及第二位置，在该位置上它允许这种运动；可由使用者操作的触发装置，以便将锁定装置从上述第一位置移到上述第二位置；以及一个安全装置，可在装置安装完毕之前有效地防止锁定装置向第二位置的移动。
在本发明的优选实施例中，下文将作更详细描述，安全装置与锁定装置相配合，从而具有一安全位置，在此位置触发装置不能将它移到第二位置；它还具有一个非安全位置，在此位置它可被移动到第二位置。
参考附图，现将进一步描述本发明。其中：
图1是据本发明的无针头注射器的实施例的纵向剖视图，所显示的注射器处在使用前，其锁定块位于安全位置；
图1a显示用在图1中的放大的锁定块；以及
图2a、2b和2c示意地显示图1和图1a实施例的部分，依次处于3个阶段，即锁定块在安全位置；锁定块在发射前的非安全位置；以及锁定块在发射期间所处的位置。
在图1的实施例中，注射力由压缩气体弹簧提供。这是以气筒130形式，其上端是封闭的并含有气体，典型地是空气，气体处于范围从5.5MPa(800Psi)到20.7MPa(3000Psi)的压力之下。气筒容纳推杆111。，推杆111的端部具有截头锥体部分131和凸台132，位于它们之间的是0形密封圈133。在使用前，推杆111由在推杆凹槽内接合的锁定块108固定在图示位置，凹槽的上表面形成推杆的靠模表面109。锁定块108按放大比例显示于图1a中。在图1所显示的位置上，锁定块不能向左移动，因为它紧靠在套筒102的内壁上。
气筒130的下端有一向外伸出的凸缘130a，通过将凸缘130a卷曲在连接套140上端的向外的凸台140a下面，可将气筒固定。套筒102由气筒位于其内的上套筒部分102a和下套筒部分102b形成。套管部分102b通过分别形成在套管部分102b和连接套140的内，外壁上的螺纹141连接到连接套上。
注射器包括药剂管103，它有活塞104，活塞104可滑动并密封地位于其内且与药剂105接触。如果从图1的上端观察，该活塞可包含一圆柱形部分，一较大直径的圆柱形密封部分，和一个截头圆锥部分，例如，下文涉及的专利号PCT/GB96/00551的图1中所示。药剂管103有一喷孔106。喷孔106由弹性密封件134密封，该密封件由密封托135固定。密封托135通过易断个连接部136与下套筒部分102b相连。
为防止意外的发射，撕裂带137设置为下套筒部分102b的下部。撕裂带137的下边缘紧靠在环142上，而该环被连接到连接套140的外表面上，或(未显示)与其形成整体。该环的作用是，只要撕裂带137存在，即阻止套管部分102a相对于连接套140向下移动。相应地，环142不需完全环绕着连接套的周边延伸，并可由一个或多个元件代替。
环状空间138形成在套筒102内壁中，在套管与气筒130相邻的地方。该空间用缓冲油脂填满(图示中顺序的黑条)从而，油脂与套筒102和气筒130直接接触。应注意，尽管被确定的环状空间从为油脂提供特定位置上看是方便的，然而它可被省忽略，油脂可仅涂敷在整个或部分气筒130外侧上和/或套筒102内侧上。
当图1的实施例要被使用时，使用者在易断连接部136上折断密封托135，随之取下密封件134，露出喷孔106。然后使用者除去撕裂带137，并抓住套筒102的上部，将喷孔紧靠待注射的物体(例如使用者自己的皮肤)，相对下套筒部分102b向下推动上套筒部分102a。这使得在上套筒部分102a壁上的开口139与锁紧块108对正，气筒130内的气体的力通过形成在推杆111的靠模表面109作用于锁定块上，使之侧向地移入开口内，从而导致注射器的发射。作为一种预防措施，如果锁定块在靠模表面109的作用下没有移动，还有一个辅助的靠模表面143形成在套管部分102a的内侧，由缓冲油脂缓冲形成的反弹。
仅作为举例的方式，下面是图1实施例典型尺寸：
气体气筒外径和滑动套筒内径之间的直径径间隙    0.05mm
横断面积(即油脂的横截面)大约                  375mm2
油脂粘度                                      2.2千泊
                                              (Kilopoise)
推杆冲击时的动量                              0.06kg.m/s
套筒部分102a的质量                            1.3g
推杆的质量                                    2.5g
推杆和活塞之间的冲击间隙                      4mm
气压                                          6.2MPa
气体气筒孔径                                  5.0mm
在油脂已被认为是一种优选的缓冲介质，而使用空气或油质缓冲装置，通常是缸体和活塞的组合，即称之为“缓冲器”，在其中，流体物质经节流流动，由此阻尼运动，也可获得相似的结果。其它粘滞阻尼方法是使用一个叶片，或多个叶片，在缓冲介质例如空气中旋转，如果适用的话，可以在特殊应用场合中使用这些方法。缓冲油脂的效果和目的在我们待审的国际申请号PCT/GB96/00551中有更详细的讨论。
应当理解，对于无针头注射器或者甚至是任何在其中储存有能量的注射器来说，不应过早的发射是重要的。一旦上述装置已组装到了撕裂带137已存在的地步，那么直至它被卸除前，该装置不能发射。但是，在纽装该装置时有一个潜在的问题，其中，待组装的倒数第二个构件是上套筒部分102a，它携带撕裂带137(最后被组装的构件是药剂管1(B)，除非套筒部分102a安装到位，意外的发射是可能的。
装配过程中的意外发射是确实可能的。首先，在上套筒部分102a安装以前紧接着有一个阶段，在该阶段，被部分安装好的装置有一段隔离期以检查气体的泄漏。其次，在上套筒部分102a安装期间，该装置将受到各种力和来自于安装设备的振动。甚至在上套筒部分102a安装后，安装药剂管所产生的装配应力足以引起意外的发射，尽管撕裂带137存在。
为解决这一问题，本装置具有一个安全装置。在图示的实施例中，这是由形成在推杆内的槽所提供的，它不仅带有靠模表面109，也带有锁定表面109a，它沿垂直于推杆轴向的方向伸展，并位于靠模表面109径向向内的位置。为能使靠模表面109和锁定表面109a的结合以按照预期的方式使用，上套筒部分102a的成形有一开口144，该开口延伸过一区域，该开口在装置被发射前与锁定块108的距推杆槽较远的一端对正。
安全装置的操作方式可从图2a、2b和2c中看出。当锁定块和推杆开始相互配合时，锁定块所占据的位置如图2a所示，这就是安全位置。在这里，接合推杆的锁紧部108a受锁紧部109a的作用。摩擦力保证锁定块与锁紧表面的保持接触；一般，推杆施加的力至少200N，因此锁定块被固定在钳形夹中。
一旦装置已经安装，特别是安装完毕后，且至少达到上套筒部分102a就位的程度，通过开口144插入一个工具，沿图中箭头P的方向推动锁定块进入图2b(和图1)所示位置。在这个位置上，接合推杆的锁紧部位108a与靠模表面109的径向内端保持接触。因此，当装置按上述方式操纵时，它能发射，且锁定块移到如图2c所示的位置。

Claims (10)

1．分送材料或物品的装置，它包括提供能量储存的弹簧，一可移动的分送构件，以在弹簧力的作用下有效的输送；锁定装置，它具有第一位置，在该位置上它限制分送构件的运动；和第二位置，在该位置上它允许这种运动；使用者操作的触发装置，以将锁定装置从上述第一位置移动到上述第二位置；以及一安全装置，以便在整个装置安装完毕之前有效地阻止锁定装置移动到上述第二位置。
2．根据权利要求1的装置，其中，由具有一安全位置锁定装置提供安全装置，在该安全位置触发装置不能将其移动到第二位置。
3．根据权利要求2的装置，其中，分送构件有一对形成在其内的锁紧连接表面，锁定装置处在它的安全位置时，它与其中之一的该表面接合，当处在它的上述第一位置时，它与另一该表面接合。
4．根据权利要求3的装置，其中，分送构件有一槽，从其外表面延伸入其中，该槽部分地由上述一对表面确定。
5．根据权利要求3或4的装置，其中，上述一个表面大体垂直于分送构件预定的运动方向，而上述另一个表面倾斜于上述的运动方向，以便分送构件沿上述方向的运动对锁定装置施加力并在锁定装置处在上述第一位置时，把它朝上述第二位置推动。
6．根据权利要求2至5的任一权利要求的装置，它具有一外壳，围绕该分送构件和该锁定装置，该外壳具有在该锁定装置的区域内的开口，，开口形成通道以允许工具插入外壳的内部并使锁定装置从它的安全位置移动到它的上述第一位置。
7．根据上述任一权利要求的装置，它为无针头注射器的形式。
8．根据权利要求7的装置，它包括含有待注射液体的腔，，在其一端形成一个输出喷孔，以及在腔内的一可移动的活塞，以通过输出喷孔排出上述液体，当锁定装置在上述第一位置时，分送构件与活塞间隔；当锁定装置移到上述第二位置时，该构件冲击活塞使其有效的移动。
9．根据上述任一权利要求的装置，其中，该弹簧是气体弹簧。
10．根据权利要求1至8的任一权利要求的装置，其中，该弹簧是机械弹簧。
CN97195179A 1996-04-11 1997-03-21 医疗用弹力分送装置 Pending CN1220613A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9607549.4 1996-04-11
GBGB9607549.4A GB9607549D0 (en) 1996-04-11 1996-04-11 Spring-powered dispensing device

Publications (1)

Publication Number Publication Date
CN1220613A true CN1220613A (zh) 1999-06-23

Family

ID=10791916

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97195179A Pending CN1220613A (zh) 1996-04-11 1997-03-21 医疗用弹力分送装置

Country Status (27)

Country Link
US (1) US6135979A (zh)
EP (1) EP0892648B1 (zh)
JP (1) JP3450012B2 (zh)
KR (1) KR20000005273A (zh)
CN (1) CN1220613A (zh)
AT (1) ATE231402T1 (zh)
AU (1) AU716237B2 (zh)
BG (1) BG102807A (zh)
BR (1) BR9708767A (zh)
CA (1) CA2251256A1 (zh)
CZ (1) CZ326698A3 (zh)
DE (1) DE69718631T2 (zh)
ES (1) ES2191822T3 (zh)
GB (1) GB9607549D0 (zh)
HU (1) HUP9902139A3 (zh)
ID (1) ID16590A (zh)
IL (1) IL126356A0 (zh)
IS (1) IS4859A (zh)
NO (1) NO984720L (zh)
NZ (1) NZ332232A (zh)
PL (1) PL329187A1 (zh)
RU (1) RU2171119C2 (zh)
SK (1) SK139398A3 (zh)
TR (1) TR199802021T2 (zh)
WO (1) WO1997037705A1 (zh)
YU (1) YU43598A (zh)
ZA (1) ZA973011B (zh)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101715371B (zh) * 2007-05-14 2012-09-05 Shl集团有限责任公司 输送装置
CN101466614B (zh) * 2006-06-13 2013-05-01 诺信公司 液体分配注射器
CN104736992A (zh) * 2012-08-30 2015-06-24 Lts勒曼治疗系统股份公司 用于将物质配送到介质中的测试装置
CN104968384A (zh) * 2012-12-17 2015-10-07 赛诺菲-安万特德国有限公司 药物输送装置
CN106975127A (zh) * 2011-02-04 2017-07-25 株式会社大赛璐 无针注射器

Families Citing this family (328)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9818110D0 (en) 1998-08-19 1998-10-14 Weston Medical Ltd Needleless injectors and other devices
US6264629B1 (en) 1998-11-18 2001-07-24 Bioject, Inc. Single-use needle-less hypodermic jet injection apparatus and method
US6132395A (en) * 1998-12-08 2000-10-17 Bioject, Inc. Needleless syringe with prefilled cartridge
US6383168B1 (en) 1998-12-08 2002-05-07 Bioject Medical Technologies Inc. Needleless syringe with prefilled cartridge
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
US7074210B2 (en) * 1999-10-11 2006-07-11 Felton International, Inc. Universal protector cap with auto-disable features for needle-free injectors
US20020193740A1 (en) 1999-10-14 2002-12-19 Alchas Paul G. Method of intradermally injecting substances
US6569123B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Prefillable intradermal injector
US6776776B2 (en) 1999-10-14 2004-08-17 Becton, Dickinson And Company Prefillable intradermal delivery device
US6494865B1 (en) 1999-10-14 2002-12-17 Becton Dickinson And Company Intradermal delivery device including a needle assembly
US6569143B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Method of intradermally injecting substances
US7887506B1 (en) 1999-11-23 2011-02-15 Pulse Needlefree Systems, Inc. Safety mechanism to prevent accidental patient injection and methods of same
US6770054B1 (en) 1999-11-23 2004-08-03 Felton International, Inc. Injector assembly with driving means and locking means
US7029457B2 (en) * 1999-11-23 2006-04-18 Felton International, Inc. Jet injector with hand piece
US6558348B2 (en) 2000-04-07 2003-05-06 Equidyne Systems, Inc. Low cost disposable needleless injector system for variable and fixed dose applications
JP2003533289A (ja) 2000-05-16 2003-11-11 ウェストン、メディカル、リミテッド 薬剤再構成用液体移送装置又は液体薬剤移送
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
AU2002254901A1 (en) 2001-02-23 2002-10-03 Smithkline Beecham Biologicals S.A. Influenza vaccine formulations for intradermal delivery
JP2002263106A (ja) * 2001-03-12 2002-09-17 Olympus Optical Co Ltd 光プローブ装置
MXPA03008316A (es) 2001-03-14 2004-09-10 Penjet Corp Metodo y sistema para remover gas disuelto de una solucion.
GB0109297D0 (en) 2001-04-12 2001-05-30 Glaxosmithkline Biolog Sa Vaccine
US6613010B2 (en) 2001-04-13 2003-09-02 Penjet Corporation Modular gas-pressured needle-less injector
WO2002087663A2 (en) 2001-04-27 2002-11-07 Penjet Corporation Method and apparatus for filling or refilling a needle-less injector
MY134424A (en) 2001-05-30 2007-12-31 Saechsisches Serumwerk Stable influenza virus preparations with low or no amount of thiomersal
US20100221284A1 (en) 2001-05-30 2010-09-02 Saech-Sisches Serumwerk Dresden Novel vaccine composition
US6824526B2 (en) 2001-10-22 2004-11-30 Penjet Corporation Engine and diffuser for use with a needle-less injector
GB0125506D0 (en) 2001-10-24 2001-12-12 Weston Medical Ltd Needle free injection method and apparatus
GB0206560D0 (en) 2002-03-20 2002-05-01 Glaxo Group Ltd Novel device
TWI314464B (en) 2002-06-24 2009-09-11 Alza Corp Reusable, spring driven autoinjector
MXPA05002072A (es) 2002-08-26 2005-06-08 Penjet Corp Aparato para inyeccion sin aguja de fluido desgasificado.
WO2005026375A2 (en) 2003-05-22 2005-03-24 Fraunhofer Usa, Inc. Recombinant carrier molecule for expression, delivery and purification of target polypeptides
WO2005034949A1 (en) 2003-09-09 2005-04-21 University Of Florida Desferrithiocin derivatives and their use as iron chelators
DE10342058B4 (de) * 2003-09-11 2007-10-25 Tecpharma Licensing Ag Verabreichungsvorrichtung für ein injizierbares Produkt mit einer Auslösesicherung
PL2332968T3 (pl) 2003-11-05 2017-08-31 Dana-Farber Cancer Institute, Inc. Stabilizowane alfa-helikalne peptydy i ich zastosowania
CA2546468C (en) 2003-12-05 2015-05-26 Aradigm Corporation A device for readying a needle free injector for delivery
US7717874B2 (en) 2004-05-28 2010-05-18 Bioject, Inc. Needle-free injection system
EP1781180A2 (en) * 2004-07-08 2007-05-09 CliniWave, Inc. Rolling tube apparatus and method for treating a wound
EP2305294B1 (en) 2004-09-22 2015-04-01 GlaxoSmithKline Biologicals SA Immunogenic composition for use in vaccination against staphylococcei
WO2007001448A2 (en) 2004-11-04 2007-01-04 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
NZ556186A (en) 2004-12-01 2010-06-25 Acushot Inc Needle-free injector
WO2006100110A1 (en) 2005-03-23 2006-09-28 Glaxosmithkline Biologicals S.A. Novel composition
MX2007012226A (es) 2005-04-04 2007-12-10 Univ Florida Analogos de polieter de desferritiocina.
WO2007117264A2 (en) 2005-08-03 2007-10-18 Fraunhofer Usa, Inc. Compositions and methods for production of immunoglobulins
US8998881B2 (en) 2005-08-10 2015-04-07 Alza Corporation Method for delivering drugs to tissue under microjet propulsion
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
WO2007070682A2 (en) 2005-12-15 2007-06-21 Massachusetts Institute Of Technology System for screening particles
KR101515078B1 (ko) 2005-12-22 2015-04-24 글락소스미스클라인 바이오로지칼즈 에스.에이. 백신
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
US8124103B2 (en) 2006-02-13 2012-02-28 Fraunhofer Usa, Inc Influenza antigens, vaccine compositions, and related methods
CA2681668C (en) 2006-03-23 2014-04-01 Michael S. Singer Compositions comprising prostaglandin f2-alpha analogs and methods for reducing body fat
EA020459B1 (ru) 2006-03-30 2014-11-28 Глаксосмитклайн Байолоджикалс С.А. Иммуногенная композиция
CA2648099C (en) 2006-03-31 2012-05-29 The Brigham And Women's Hospital, Inc System for targeted delivery of therapeutic agents
CA2652280C (en) 2006-05-15 2014-01-28 Massachusetts Institute Of Technology Polymers for functional particles
EP2492684B1 (en) 2006-06-02 2016-12-28 President and Fellows of Harvard College Protein surface remodeling
WO2007150030A2 (en) 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
PL2422810T3 (pl) 2006-07-17 2015-03-31 Glaxosmithkline Biologicals Sa Szczepionka przeciw grypie
WO2008021367A2 (en) 2006-08-11 2008-02-21 President And Fellows Of Harvard College Moenomycin biosynthesis-related compositions and methods of use thereof
US7547293B2 (en) 2006-10-06 2009-06-16 Bioject, Inc. Triggering mechanism for needle-free injector
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
PT2086582E (pt) 2006-10-12 2013-01-25 Glaxosmithkline Biolog Sa Vacina compreendendo uma emulsão adjuvante óleo em água
EP2433648A3 (en) 2006-10-12 2012-04-04 GlaxoSmithKline Biologicals S.A. Vaccine comprising an oil in water emulsion adjuvant
KR20090106493A (ko) 2006-12-01 2009-10-09 안테리오스, 인코퍼레이티드 양쪽성 엔티티 나노입자
CA2984226C (en) 2006-12-26 2021-02-23 Lantheus Medical Imaging, Inc. Ligands for imaging cardiac innervation
US8889632B2 (en) 2007-01-31 2014-11-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
EP2134830A2 (en) 2007-02-09 2009-12-23 Massachusetts Institute of Technology Oscillating cell culture bioreactor
WO2008103997A2 (en) 2007-02-23 2008-08-28 Bioject Inc. Needle-free injection devices and drug delivery systems therefor
EP2137170B1 (en) 2007-03-15 2016-03-09 University of Florida Research Foundation, Inc. Desferrithiocin polyether analogues
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
CN101730708B (zh) 2007-03-28 2013-09-18 哈佛大学校长及研究员协会 缝合多肽
WO2008124639A2 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Poly (amino acid) targeting moieties
WO2008134643A2 (en) 2007-04-28 2008-11-06 Fraunhofer Usa, Inc. Trypanosoma antigens, vaccine compositions, and related methods
US8524444B2 (en) 2007-06-15 2013-09-03 President And Fellows Of Harvard College Methods and compositions for detections and modulating O-glycosylation
ES2552366T3 (es) 2007-06-26 2015-11-27 Glaxosmithkline Biologicals S.A. Vacuna que comprende conjugados de polisacárido capsular de Streptococcus pneumoniae
CA2692933C (en) 2007-07-11 2016-10-18 Fraunhofer Usa, Inc. Yersinia pestis antigens, vaccine compositions, and related methods
US8604004B2 (en) 2007-10-04 2013-12-10 President And Fellows Of Harvard College Moenomycin analogs, methods of synthesis, and uses thereof
ES2627292T3 (es) 2007-10-12 2017-07-27 Massachusetts Institute Of Technology Nanotecnología de vacunas
AU2009204345A1 (en) 2008-01-03 2009-07-16 Massachusetts Institute Of Technology Decoy influenza therapies
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
PT2271360E (pt) 2008-04-16 2015-12-07 Glaxosmithkline Biolog Sa Vacina
JP2011518881A (ja) 2008-04-28 2011-06-30 ゾゲニクス インコーポレーティッド 片頭痛の治療のための製剤
MX2010013562A (es) 2008-06-26 2011-02-15 Anterios Inc Aplicacion dermica.
WO2010009271A2 (en) 2008-07-15 2010-01-21 Academia Sinica Glycan arrays on ptfe-like aluminum coated glass slides and related methods
WO2010011313A2 (en) 2008-07-23 2010-01-28 President And Fellows Of Harvard College Ligation of stapled polypeptides
CA2737921C (en) 2008-09-22 2019-01-15 Aileron Therapeutics, Inc. Methods for preparing purified alpha-helical peptidomimetic macrocycle compositions with low metal ppm levels
US8734803B2 (en) 2008-09-28 2014-05-27 Ibio Inc. Humanized neuraminidase antibody and methods of use thereof
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
US8343498B2 (en) 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
EP2376089B1 (en) 2008-11-17 2018-03-14 The Regents of the University of Michigan Cancer vaccine compositions and methods of using the same
US9637746B2 (en) 2008-12-15 2017-05-02 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways
DE102008063517A1 (de) * 2008-12-18 2010-07-01 Lts Lohmann Therapie-Systeme Ag Einmalinjektor mit einem biegeelastischen Gehäuse II
DE102008063519A1 (de) * 2008-12-18 2010-07-01 Lts Lohmann Therapie-Systeme Ag Einmalinjektor mit einem biegeelastischen Metallgehäuse
JP2012515172A (ja) 2009-01-14 2012-07-05 エルロン・セラピューティクス・インコーポレイテッド ペプチド模倣大環状分子
EP2424877A4 (en) 2009-04-28 2013-01-02 Harvard College SUPERCHARGED PROTEINS FOR CELL PENETRATION
US8957075B2 (en) 2009-06-01 2015-02-17 President And Fellows Of Harvard College O-GlcNAc transferase inhibitors and uses thereof
CN102510755A (zh) 2009-07-13 2012-06-20 哈佛大学校长及研究员协会 双功能钉接多肽和其用途
GB0913681D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
CA2774973A1 (en) 2009-09-22 2011-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2011041391A1 (en) 2009-09-29 2011-04-07 Fraunhofer Usa, Inc. Influenza hemagglutinin antibodies, compositions, and related methods
GB2477487A (en) * 2009-10-12 2011-08-10 Owen Mumford Ltd Injection device
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
GB0921295D0 (en) 2009-12-04 2010-01-20 Owen Mumford Ltd Injection appaeratus
EP2528615B1 (en) 2010-01-27 2020-05-13 Massachusetts Institute of Technology Engineered polypeptide agents for targeted broad spectrum influenza neutralization
JP5827962B2 (ja) 2010-03-08 2015-12-02 スローン ケタリング インスティテュート フォア キャンサー リサーチ Ｃｄｃ７キナーゼ阻害剤およびその使用
GB201003922D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Conjugation process
GB201003920D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Method of treatment
EP2550285B1 (en) 2010-03-22 2017-07-19 President and Fellows of Harvard College Trioxacarcins and uses thereof
WO2011130332A1 (en) 2010-04-12 2011-10-20 Academia Sinica Glycan arrays for high throughput screening of viruses
EP2566853B1 (en) 2010-05-05 2017-01-25 Infinity Pharmaceuticals, Inc. Tetrazolones as inhibitors of fatty acid synthase
US8450350B2 (en) 2010-05-05 2013-05-28 Infinity Pharmaceuticals, Inc. Triazoles as inhibitors of fatty acid synthase
US8956833B2 (en) 2010-05-07 2015-02-17 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways through enzyme relocation
KR102136503B1 (ko) 2010-05-11 2020-07-21 랜티우스 메디컬 이메징, 인크. 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템
EP2571875A4 (en) 2010-05-14 2013-10-30 Dana Farber Cancer Inst Inc CONTRACEPTIVE COMPOSITIONS FOR MEN AND METHODS OF USE THEREOF
WO2011160042A2 (en) 2010-06-18 2011-12-22 Makoto Life Sciences, Inc. Prpk-tprkb modulators and uses thereof
EP3578205A1 (en) 2010-08-06 2019-12-11 ModernaTX, Inc. A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof
CA2807685C (en) 2010-08-13 2020-10-06 Aileron Therapeutics, Inc. P53 derived peptidomimetic macrocycle
EP2611922A1 (en) 2010-08-31 2013-07-10 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways through protease manipulation
JP5856621B2 (ja) 2010-09-15 2016-02-10 ゾゲニクス インコーポレーティッド 無針注射器および注射性能を最適化する同注射器の設計パラメータ
CA2811023A1 (en) 2010-09-21 2012-03-29 Massachusetts Institute Of Technology Influenza treatment and/or characterization; human-adapted ha polypeptides; vaccines
WO2012040459A2 (en) 2010-09-22 2012-03-29 President And Fellows Of Harvard College Beta-catenin targeting peptides and uses thereof
CA2813466A1 (en) 2010-10-01 2012-04-05 Moderna Therapeutics, Inc. Modified nucleosides, nucleotides, and nucleic acids that disrupt major groove binding partner interactions
CA2813078A1 (en) 2010-10-04 2012-04-12 Massachusetts Institute Of Technology Hemagglutinin polypeptides, and reagents and methods relating thereto
EP2438945A1 (en) * 2010-10-08 2012-04-11 Sanofi-Aventis Deutschland GmbH Reusable engine for an auto-injector
EP2637669A4 (en) 2010-11-10 2014-04-02 Infinity Pharmaceuticals Inc Heterocyclic compounds and their use
WO2012096889A1 (en) * 2011-01-10 2012-07-19 Zogenix, Inc. Improved needle free injectors
CA2824197C (en) 2011-01-10 2020-02-25 Michael Martin Processes for preparing isoquinolinones and solid forms of isoquinolinones
ES2687494T3 (es) 2011-01-19 2018-10-25 Topokine Therapeutics, Inc. Métodos y composiciones para reducir la grasa corporal
KR20140003572A (ko) 2011-01-24 2014-01-09 안테리오스, 인코퍼레이티드 나노입자 조성물
JP2014503586A (ja) 2011-01-24 2014-02-13 アンテリオス， インコーポレイテッド 油組成物
AU2012209274A1 (en) 2011-01-24 2013-09-12 Anterios, Inc. Nanoparticle compositions, formulations thereof, and uses therefor
EP2680837A4 (en) 2011-03-03 2015-06-03 Tersus Pharmaceuticals Llc COMPOSITIONS AND METHODS COMPRISING C16: 1N7-PALMITOLATE
GB201103836D0 (en) 2011-03-07 2011-04-20 Glaxosmithkline Biolog Sa Conjugation process
US9193767B2 (en) 2011-03-30 2015-11-24 Brown University Enopeptins, uses thereof, and methods of synthesis thereto
CA2831613A1 (en) 2011-03-31 2012-10-04 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
US20140072622A1 (en) 2011-05-17 2014-03-13 Glaxosmithkline Biologicals S.A. Vaccine against streptococcus pneumoniae
JP6061922B2 (ja) 2011-06-22 2017-01-18 ザ ジェネラル ホスピタル コーポレイション プロテイノパチーの処置方法
CA2842190A1 (en) 2011-07-19 2013-01-24 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
US8969363B2 (en) 2011-07-19 2015-03-03 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
EP3483150A1 (en) 2011-07-22 2019-05-15 Massachusetts Institute Of Technology Activators of class 1 histone deacetylases (hdacs) and uses thereof
RU2014111823A (ru) 2011-08-29 2015-10-10 Инфинити Фармасьютикалз, Инк. Гетероциклические соединения и их применения
EP2753702B1 (en) 2011-09-09 2021-12-15 GreenLight Biosciences, Inc. Cell-free preparation of carbapenems
ES2731471T3 (es) 2011-09-09 2019-11-15 Lantheus Medical Imaging Inc Composiciones, métodos y sistemas para la síntesis y el uso de agentes de obtención de imágenes
EP2755693A4 (en) 2011-09-12 2015-05-20 Moderna Therapeutics Inc MODIFIED NUCLEIC ACIDS AND METHODS OF USE
US9630979B2 (en) 2011-09-29 2017-04-25 Infinity Pharmaceuticals, Inc. Inhibitors of monoacylglycerol lipase and methods of their use
CN110511939A (zh) 2011-10-03 2019-11-29 现代泰克斯公司 修饰的核苷、核苷酸和核酸及其用途
US9096684B2 (en) 2011-10-18 2015-08-04 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2013074986A1 (en) 2011-11-17 2013-05-23 Dana-Farber Cancer Institute, Inc. Inhibitors of c-jun-n-terminal kinase (jnk)
GB201120000D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
GB201119999D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
EP2791160B1 (en) 2011-12-16 2022-03-02 ModernaTX, Inc. Modified mrna compositions
US8426471B1 (en) 2011-12-19 2013-04-23 Topokine Therapeutics, Inc. Methods and compositions for reducing body fat and adipocytes
WO2013123266A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
JP6450192B2 (ja) 2012-02-15 2019-01-09 エイルロン セラピューティクス，インコーポレイテッド トリアゾール架橋した、およびチオエーテル架橋したペプチドミメティック大環状化合物
WO2013152277A2 (en) 2012-04-06 2013-10-10 President And Fellows Of Harvard College Moenomycin analogs, methods of synthesis, and uses thereof
US9902985B2 (en) 2012-04-06 2018-02-27 President And Fellows Of Harvard College Chemoenzymatic methods for synthesizing moenomycin analogs
WO2013151697A1 (en) 2012-04-06 2013-10-10 President And Fellows Of Harvard College Methods and compounds for identifying glycosyltransferase inhibitors
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
EP2841098A4 (en) 2012-04-23 2016-03-02 Allertein Therapeutics Llc NANOPARTICLES FOR THE TREATMENT OF ALLERGIES
EP2841128A4 (en) 2012-04-23 2015-11-25 Zogenix Inc PISTON CLOSURES FOR MEDICINAL PACKAGING CAPSULES
CN109265541A (zh) 2012-05-10 2019-01-25 麻省理工学院 流感中和药剂
JP2015525794A (ja) 2012-08-06 2015-09-07 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 乳児においてｒｓｖ及び百日咳菌に対する免疫応答を惹起するための方法
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
JP6302909B2 (ja) 2012-08-18 2018-03-28 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ シアリダーゼの同定および画像化のための細胞透過性プローブ
CA3113959A1 (en) 2012-09-26 2014-04-03 President And Fellows Of Harvard College Proline-locked stapled peptides and uses thereof
US20150225471A1 (en) 2012-10-01 2015-08-13 President And Fellows Of Harvard College Stabilized polypeptide insulin receptor modulators
RS58700B1 (sr) 2012-10-12 2019-06-28 Broad Inst Inc Gsk3 inhibitori i postupci njihove primene
US10112927B2 (en) 2012-10-18 2018-10-30 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
US9758522B2 (en) 2012-10-19 2017-09-12 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged small molecules as inducers of protein degradation
US9604919B2 (en) 2012-11-01 2017-03-28 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
PT2914296T (pt) 2012-11-01 2018-10-30 Infinity Pharmaceuticals Inc Tratamento de cancros utilizando moduladores de isoformas de pi3-quinase
WO2014071247A1 (en) 2012-11-02 2014-05-08 Dana-Farber Cancer Institute, Inc. Pyrrol-1 -yl benzoic acid derivates useful as myc inhibitors
MX2015006390A (es) 2012-11-21 2015-08-05 Topokine Therapeutics Inc Metodos y composiciones para incrementar localmente la grasa corporal.
PT2922554T (pt) 2012-11-26 2022-06-28 Modernatx Inc Arn modificado nas porções terminais
JP6408478B2 (ja) 2012-11-26 2018-10-17 プレジデント アンド フェローズ オブ ハーバード カレッジ トリオキサカルシン、トリオキサカルシン−抗体複合体、およびその用途
WO2014100716A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors and uses thereof
US9604930B2 (en) 2012-12-21 2017-03-28 Epizyme, Inc. Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof
CA2894126A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors and uses thereof
US8940726B2 (en) 2012-12-21 2015-01-27 Epizyme, Inc. PRMT5 inhibitors and uses thereof
JP2016504050A (ja) 2013-01-17 2016-02-12 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 細胞表現型の改変のためのシグナルセンサーポリヌクレオチド
CA2900008A1 (en) 2013-02-07 2014-08-14 Children's Medical Center Corporation Protein antigens that provide protection against pneumococcal colonization and/or disease
SG11201505744XA (en) 2013-02-07 2015-08-28 Massachusetts Inst Technology Human adaptation of h5 influenza
JP2016512523A (ja) 2013-03-11 2016-04-28 デュレクト コーポレーション 高粘性液体キャリアを含む注射用制御放出組成物
WO2014159813A1 (en) 2013-03-13 2014-10-02 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
CN110105434A (zh) 2013-03-13 2019-08-09 哈佛大学的校长及成员们 钉合且缝合的多肽及其用途
NZ629037A (en) 2013-03-15 2017-04-28 Infinity Pharmaceuticals Inc Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
MX2015013894A (es) 2013-04-03 2015-12-11 Allertein Therapeutics Llc Composiciones de nanoparticulas novedosas.
CA3130061A1 (en) 2013-04-04 2014-10-09 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
ES2774330T3 (es) 2013-04-09 2020-07-20 Massachusetts Inst Technology Polímero de suministro de fármaco y usos del mismo
US10301359B2 (en) 2013-04-30 2019-05-28 Massachusetts Institute Of Technology Human adaptation of H3 influenza
US9315472B2 (en) 2013-05-01 2016-04-19 Massachusetts Institute Of Technology 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
NO2753788T3 (zh) 2013-05-10 2018-06-16
KR20160013204A (ko) 2013-05-30 2016-02-03 인피니티 파마슈티칼스, 인코포레이티드 Pi3 키나아제 동형단백질 조절제를 사용하는 암의 치료
WO2014197723A2 (en) 2013-06-05 2014-12-11 Massachusetts Institute Of Technology Human adaptation of h7 ha
CA2914815A1 (en) 2013-06-11 2014-12-18 Kala Pharmaceuticals, Inc. Urea derivatives and uses thereof
JP2016523241A (ja) 2013-06-14 2016-08-08 プレジデント アンド フェローズ オブ ハーバード カレッジ 安定化されたポリペプチドインスリン受容体調節剤
US10086054B2 (en) 2013-06-26 2018-10-02 Academia Sinica RM2 antigens and use thereof
WO2014210564A1 (en) 2013-06-27 2014-12-31 Academia Sinica Glycan conjugates and use thereof
CN105611835A (zh) 2013-07-25 2016-05-25 达纳-法伯癌症研究所股份有限公司 转录因子抑制剂及其用途
EP3492097A1 (en) 2013-08-05 2019-06-05 GlaxoSmithKline Biologicals S.A. Combination immunogenic compositions
CA2919383A1 (en) 2013-08-05 2015-02-12 Greenlight Biosciences, Inc. Engineered proteins with a protease cleavage site
CA2923579C (en) 2013-09-06 2023-09-05 Academia Sinica Human inkt cell activation using glycolipids with altered glycosyl groups
US9751888B2 (en) 2013-10-04 2017-09-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
BR112016007467B1 (pt) 2013-10-04 2022-09-20 Infinity Pharmaceuticals, Inc Compostos heterocíclicos e usos dos mesmos
WO2015057894A1 (en) 2013-10-15 2015-04-23 Massachusetts Institute Of Technology Methods for treating polycystic kidney disease and polycystic liver disease
US9902986B2 (en) 2013-10-16 2018-02-27 Massachusetts Institute Of Technology Enterobactin conjugates and uses thereof
JP6491202B2 (ja) 2013-10-18 2019-03-27 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド サイクリン依存性キナーゼ７（ｃｄｋ７）の多環阻害剤
US20160244452A1 (en) 2013-10-21 2016-08-25 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
KR20160099084A (ko) 2013-11-01 2016-08-19 칼라 파마슈티컬스, 인크. 치료 화합물의 결정질 형태 및 그의 용도
US11446309B2 (en) 2013-11-08 2022-09-20 Dana-Farber Cancer Institute, Inc. Combination therapy for cancer using bromodomain and extra-terminal (BET) protein inhibitors
TN2016000240A1 (en) 2013-12-24 2017-10-06 Harvard College Cortistatin analogues and syntheses and uses thereof.
CA2937123A1 (en) 2014-01-16 2015-07-23 Academia Sinica Compositions and methods for treatment and detection of cancers
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
US10793571B2 (en) 2014-01-31 2020-10-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
CN106456653A (zh) 2014-02-28 2017-02-22 腾沙治疗公司 高胰岛素血症相关病症的治疗
AU2015226911B2 (en) 2014-03-07 2018-03-01 The Arizona Board Of Regents On Behalf Of The University Of Arizona Non-narcotic CRMP2 peptides targeting sodium channels for chronic pain
CN113620958A (zh) 2014-03-19 2021-11-09 无限药品股份有限公司 用于治疗PI3K-γ介导的障碍的杂环化合物
CN106415244B (zh) 2014-03-27 2020-04-24 中央研究院 反应性标记化合物及其用途
CN113403338A (zh) 2014-03-28 2021-09-17 华盛顿大学商业中心 乳腺癌和卵巢癌疫苗
WO2015168079A1 (en) 2014-04-29 2015-11-05 Infinity Pharmaceuticals, Inc. Pyrimidine or pyridine derivatives useful as pi3k inhibitors
US10039816B2 (en) 2014-04-30 2018-08-07 Massachusetts Institute Of Technology Siderophore-based immunization against gram-negative bacteria
WO2015172686A1 (zh) * 2014-05-14 2015-11-19 苏州大学张家港工业技术研究院 气动蓄能式无针注射器
CN111620940A (zh) 2014-05-21 2020-09-04 哈佛大学的校长及成员们 Ras抑制肽和其用途
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
EP4116329A1 (en) 2014-05-27 2023-01-11 Academia Sinica Anti-her2 glycoantibodies and uses thereof
TWI717319B (zh) 2014-05-27 2021-02-01 中央研究院 得自類桿菌屬之岩藻糖苷酶及其用途
EP3149036A4 (en) 2014-05-27 2017-12-27 Academia Sinica Anti-cd20 glycoantibodies and uses thereof
TWI732738B (zh) 2014-05-28 2021-07-11 中央研究院 抗TNF-α醣抗體及其用途
MX2016016533A (es) 2014-06-13 2017-05-01 Glaxosmithkline Biologicals Sa Combinaciones inmunogenas.
GEP20197011B (en) 2014-06-19 2019-08-12 Ariad Pharma Inc Heteroaryl compounds for kinase inhibition
US10188661B2 (en) 2014-06-27 2019-01-29 Topokine Therapeutics, Inc. Topical dosage regimen
WO2016004202A1 (en) 2014-07-02 2016-01-07 Massachusetts Institute Of Technology Polyamine-fatty acid derived lipidoids and uses thereof
WO2016011386A1 (en) 2014-07-18 2016-01-21 University Of Washington Cancer vaccine compositions and methods of use thereof
US10736966B2 (en) 2014-08-12 2020-08-11 Massachusetts Institute Of Technology Brush-poly (glycoamidoamine)-lipids and uses thereof
CA2960712A1 (en) 2014-09-08 2016-03-17 Academia Sinica Human inkt cell activation using glycolipids
SG11201702175YA (en) 2014-09-24 2017-04-27 Aileron Therapeutics Inc Peptidomimetic macrocycles and formulations thereof
AU2015320549A1 (en) 2014-09-24 2017-04-13 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
RS60737B1 (sr) 2014-10-21 2020-09-30 Ariad Pharma Inc Kristalni oblici 5-hloro-n4-[-2-(dimetilfosforil)fenil]-n2-{2-metoksi-4-[4-(4-metilpiperazin-1-il)piperidin-1-il]pirimidin-2,4-diamina
KR20170068597A (ko) 2014-10-27 2017-06-19 텐샤 세러퓨틱스 인코포레이티드 브로모도메인 저해제
WO2016066618A2 (en) 2014-10-28 2016-05-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Compositions and methods for antigen-specific tolerance
EP3041948B1 (en) 2014-11-10 2019-01-09 Modernatx, Inc. Alternative nucleic acid molecules containing reduced uracil content and uses thereof
US10253045B2 (en) 2014-11-26 2019-04-09 Kala Pharmaceuticals, Inc. Crystalline forms of a therapeutic compound and uses thereof
EP3230272B1 (en) 2014-12-10 2020-08-19 Kala Pharmaceuticals, Inc. 1-amino-triazolo(1,5-a)pyridine-substituted urea derivative and uses thereof
EP3237066B1 (en) 2014-12-23 2020-10-21 Sloan-Kettering Institute for Cancer Research Polymorph of granaticin b
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
CA2972072A1 (en) 2015-01-24 2016-07-28 Academia Sinica Novel glycan conjugates and methods of use thereof
BR112017019738A2 (pt) 2015-03-20 2018-05-29 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos
WO2016160617A2 (en) 2015-03-27 2016-10-06 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
MY193444A (en) 2015-03-30 2022-10-13 Greenlight Biosciences Inc Cell-free production of ribonucleic acid
WO2016176343A1 (en) 2015-04-27 2016-11-03 University Of Florida Research Foundation, Incorporated Metabolically programmed metal chelators and uses thereof
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
RS64331B1 (sr) 2015-06-19 2023-08-31 Massachusetts Inst Technology Alkenil supstituisani 2,5-piperazindioni i njihova primena u sastavima za isporuku agensa u organizam ili ćeliju subjekta
WO2017004548A1 (en) 2015-07-01 2017-01-05 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
EP3347372A4 (en) 2015-09-10 2019-09-04 Aileron Therapeutics, Inc. PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF MCL-1
PT3350157T (pt) 2015-09-17 2022-03-18 Modernatx Inc Compostos e composições para administração intracelular de agentes terapêuticos
CA2998370A1 (en) 2015-09-17 2017-03-23 Moderna Therapeutics, Inc. Polynucleotides containing a stabilizing tail region
WO2017059389A1 (en) 2015-10-01 2017-04-06 Kythera Biopharmaceuticals, Inc. Compositions comprising a statin for use in methods of adipolysis
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
ES2913626T3 (es) 2015-12-22 2022-06-03 Modernatx Inc Compuestos y composiciones para la administración intracelular de agentes
CA3016170A1 (en) 2016-03-08 2017-09-14 Academia Sinica Methods for modular synthesis of n-glycans and arrays thereof
US10759806B2 (en) 2016-03-17 2020-09-01 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors
BR112018070506A2 (pt) 2016-04-06 2019-01-29 Greenlight Biosciences Inc produção isenta de células de ácido ribonucleico
BR112018075078A2 (pt) 2016-06-03 2019-03-06 Sanofi Pasteur Inc. modificação de polipeptídeos da hemaglutinina do influenza manipulados
WO2017214337A1 (en) 2016-06-07 2017-12-14 Massachusetts Institute Of Technology Drug delivery polymers and uses thereof
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US10792432B2 (en) 2016-06-09 2020-10-06 Becton, Dickinson And Company Drive assembly and spacer for drug delivery system
US10549044B2 (en) 2016-06-09 2020-02-04 Becton, Dickinson And Company Spacer assembly for drug delivery system
US10751476B2 (en) 2016-06-09 2020-08-25 Becton, Dickinson And Company Actuator assembly for drug delivery system
US10603445B2 (en) 2016-06-09 2020-03-31 Becton, Dickinson And Company Needle actuator assembly for drug delivery system
US20200069599A1 (en) 2016-06-14 2020-03-05 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
GB201610599D0 (en) 2016-06-17 2016-08-03 Glaxosmithkline Biologicals Sa Immunogenic Composition
CA3031797A1 (en) 2016-08-05 2018-02-08 Sanofi Pasteur, Inc. Multivalent pneumococcal polysaccharide-protein conjugate composition
MX2019001342A (es) 2016-08-05 2019-07-04 Sanofi Pasteur Inc Composicion de conjugado de proteina-polisacarido de neumococo multivalente.
CA3034057A1 (en) 2016-08-22 2018-03-01 CHO Pharma Inc. Antibodies, binding fragments, and methods of use
WO2018089540A1 (en) 2016-11-08 2018-05-17 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
WO2018106738A1 (en) 2016-12-05 2018-06-14 Massachusetts Institute Of Technology Brush-arm star polymers, conjugates and particles, and uses thereof
AU2018234828A1 (en) 2017-03-15 2019-09-19 Modernatx, Inc. Lipid nanoparticle formulation
ES2940259T3 (es) 2017-03-15 2023-05-04 Modernatx Inc Compuesto y composiciones para la administración intracelular de agentes terapéuticos
EP3601326A4 (en) 2017-03-20 2020-12-16 The Broad Institute, Inc. COMPOUNDS AND METHODS OF REGULATING INSULIN SECRETION
WO2018232120A1 (en) 2017-06-14 2018-12-20 Modernatx, Inc. Compounds and compositions for intracellular delivery of agents
BR112019027387A8 (pt) 2017-06-23 2022-12-06 Univ Maryland Composições imunogênicas
WO2019013790A1 (en) 2017-07-12 2019-01-17 Curza Global, Llc ANTIMICROBIAL COMPOUNDS AND USES THEREOF
WO2019013789A1 (en) 2017-07-12 2019-01-17 Curza Global, Llc ANTIMICROBIAL COMPOUNDS
US11744801B2 (en) 2017-08-31 2023-09-05 Modernatx, Inc. Methods of making lipid nanoparticles
MX2020003841A (es) 2017-10-11 2020-11-06 Greenlight Biosciences Inc Métodos y composiciones para la producción de nucleósido trifosfatos y ácidos ribonucleicos.
MX2020003850A (es) 2017-10-16 2020-08-13 Becton Dickinson Co Conjunto de separador para dispositivo de administracion de farmacos.
WO2019109079A1 (en) 2017-12-01 2019-06-06 North Carolina State University Fibrin particles and methods of making the same
GB201721576D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa Hla antigens and glycoconjugates thereof
GB201721582D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa S aureus antigens and immunogenic compositions
US20220409536A1 (en) 2018-09-19 2022-12-29 Modernatx, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
US20210378980A1 (en) 2018-09-20 2021-12-09 Modernatx, Inc. Preparation of lipid nanoparticles and methods of administration thereof
CA3126798A1 (en) 2019-01-16 2020-07-23 Curza Global, Llc Antimicrobial compounds and methods
CA3126815A1 (en) 2019-01-16 2020-07-23 Curza Global, Llc Antimicrobial compounds and methods
MX2021009245A (es) 2019-01-31 2021-11-12 Modernatx Inc Metodos de preparacion de nanoparticulas lipidicas.
WO2020168466A1 (en) 2019-02-19 2020-08-27 Stemirna Therapeutics Co., Ltd. Modified nucleoside and synthetic methods thereof
CA3149386A1 (en) 2019-07-31 2021-02-04 Modernatx, Inc. Compositions and methods for delivery of rna interference agents to immune cells
BR112022001654A2 (pt) 2019-07-31 2022-07-12 Sanofi Pasteur Inc Composições conjugadas de proteinas de polissacarídeos pneumocócicos multivalentes e métodos de utilização dos mesmos
AU2020384885A1 (en) 2019-11-13 2022-06-09 Curza Global, Llc Antimicrobial compounds and methods
BR112022014970A2 (pt) 2020-01-31 2022-09-20 Modernatx Inc Métodos para preparar nanopartículas lipídicas
US11642407B2 (en) 2020-02-28 2023-05-09 Massachusetts Institute Of Technology Identification of variable influenza residues and uses thereof
WO2021231729A1 (en) 2020-05-13 2021-11-18 Sanofi Adjuvanted stabilized stem hemagglutinin nanoparticles and methods of using the same to induce broadly neutralizing antibodies against influenza
US20230390296A1 (en) 2020-10-30 2023-12-07 Keio University Novel treatment and prevention of sarcopenia-related diseases
JPWO2022092295A1 (zh) 2020-10-30 2022-05-05
TW202237068A (zh) 2020-12-09 2022-10-01 美商建南德克公司 製備脂質奈米顆粒的高通量方法及其用途
WO2022146931A1 (en) * 2021-01-03 2022-07-07 Fpin Llc Damped autoinjectors
WO2022192176A1 (en) 2021-03-09 2022-09-15 Massachusetts Institute Of Technology Branched poly(-amino esters) for the delivery of nucleic acids
TW202313065A (zh) 2021-05-28 2023-04-01 美商季卡尼醫療公司 用於治療遺傳疾病之化合物
WO2023018817A1 (en) 2021-08-11 2023-02-16 Sanofi Pasteur Inc. Truncated influenza neuraminidase and methods of using the same
WO2023039108A1 (en) 2021-09-08 2023-03-16 Affinivax, Inc. Coronavirus vaccine
TW202333778A (zh) 2021-10-08 2023-09-01 美商賽諾菲巴斯德公司 多價流感疫苗
WO2023081798A1 (en) 2021-11-05 2023-05-11 Sanofi Pasteur Inc. Multivalent influenza vaccines comprising recombinant hemagglutinin and neuraminidase and methods of using the same
WO2023079113A1 (en) 2021-11-05 2023-05-11 Sanofi Hybrid multivalent influenza vaccines comprising hemagglutinin and neuraminidase and methods of using the same
TW202333654A (zh) 2021-12-16 2023-09-01 美商現代公司 用於製備脂質奈米顆粒之方法
WO2023129963A1 (en) 2021-12-30 2023-07-06 Curza Global, Llc Antimicrobial compounds and methods
WO2023144206A1 (en) 2022-01-27 2023-08-03 Sanofi Pasteur Modified vero cells and methods of using the same for virus production
WO2023177577A1 (en) 2022-03-14 2023-09-21 Sanofi Pasteur Inc. Machine-learning techniques in protein design for vaccine generation
WO2023193002A1 (en) 2022-04-01 2023-10-05 Modernatx, Inc. Cross mixers for lipid nanoparticle production, and methods of operating the same
WO2023235380A1 (en) 2022-06-01 2023-12-07 Zikani Therapeutics, Inc. Macrolides for treating genetic diseases
WO2023250513A1 (en) 2022-06-24 2023-12-28 Zikani Therapeutics, Inc. 13-membered macrolide compounds for treating diseases mediated by abnormal protein translation
WO2024026487A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Lipid nanoparticle compositions comprising phospholipid derivatives and related uses
WO2024026482A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Lipid nanoparticle compositions comprising surface lipid derivatives and related uses
WO2024026475A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Compositions for delivery to hematopoietic stem and progenitor cells (hspcs) and related uses
WO2024049994A1 (en) 2022-09-01 2024-03-07 Zikani Therapeutics, Inc. Treatment of familial adenomatous polyopsis using a 13-membered macrolide

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR824357A (fr) * 1936-10-21 1938-02-07 Procédé et dispositifs pour l'introduction de gaz et notamment d'air comprimé dans des ampoules hypodermiques et autres et la fermeture de ces ampoules
US2680439A (en) * 1948-09-08 1954-06-08 Arnold K Sutermeister High-pressure injection device
US2653602A (en) * 1950-06-17 1953-09-29 Becton Dickinson Co Injection device
US3217712A (en) * 1963-01-22 1965-11-16 Otto Konigslow Mfg Company Ampoule applicator
DE6944378U (de) * 1969-11-14 1970-04-16 Georg A Henke Gmbh Fa Selbsttaetiges injektionsgeraet
US3945383A (en) * 1974-08-08 1976-03-23 Smithkline Corporation Unit dose ampul for jet injector
US4351692A (en) * 1981-01-07 1982-09-28 Ouellette Machinery Systems Apparatus and method for automatically filling and heat weld sealing lengths of plastic tubing
US4596556A (en) * 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
US5026349A (en) * 1988-10-05 1991-06-25 Autoject Systems Inc. Liquid medicament injector system
US4902279A (en) * 1988-10-05 1990-02-20 Autoject Systems Inc. Liquid medicament safety injector
GB9118204D0 (en) * 1991-08-23 1991-10-09 Weston Terence E Needle-less injector
JPH08505543A (ja) * 1992-11-19 1996-06-18 テブロ ソシエテ アノニム 予充填注射器用の使い捨て自動注射装置
US5891086A (en) * 1993-07-31 1999-04-06 Weston Medical Limited Needle-less injector
GB9504878D0 (en) * 1995-03-10 1995-04-26 Weston Medical Ltd Viscously coupled actuator
US5865795A (en) * 1996-02-29 1999-02-02 Medi-Ject Corporation Safety mechanism for injection devices

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101466614B (zh) * 2006-06-13 2013-05-01 诺信公司 液体分配注射器
CN101715371B (zh) * 2007-05-14 2012-09-05 Shl集团有限责任公司 输送装置
CN106975127A (zh) * 2011-02-04 2017-07-25 株式会社大赛璐 无针注射器
CN104736992A (zh) * 2012-08-30 2015-06-24 Lts勒曼治疗系统股份公司 用于将物质配送到介质中的测试装置
CN104968384A (zh) * 2012-12-17 2015-10-07 赛诺菲-安万特德国有限公司 药物输送装置

Also Published As

Publication number Publication date
EP0892648B1 (en) 2003-01-22
IS4859A (is) 1998-10-06
CZ326698A3 (cs) 1999-04-14
WO1997037705A1 (en) 1997-10-16
JP2000508189A (ja) 2000-07-04
HUP9902139A2 (hu) 1999-11-29
TR199802021T2 (xx) 1999-01-18
NO984720D0 (no) 1998-10-09
SK139398A3 (en) 1999-03-12
HUP9902139A3 (en) 2000-01-28
BR9708767A (pt) 1999-08-03
NO984720L (no) 1998-10-09
ID16590A (id) 1997-10-16
KR20000005273A (ko) 2000-01-25
US6135979A (en) 2000-10-24
PL329187A1 (en) 1999-03-15
BG102807A (en) 1999-04-30
AU2038797A (en) 1997-10-29
IL126356A0 (en) 1999-05-09
ATE231402T1 (de) 2003-02-15
DE69718631D1 (de) 2003-02-27
AU716237B2 (en) 2000-02-24
EP0892648A1 (en) 1999-01-27
CA2251256A1 (en) 1997-10-16
ES2191822T3 (es) 2003-09-16
JP3450012B2 (ja) 2003-09-22
NZ332232A (en) 1999-08-30
DE69718631T2 (de) 2003-12-18
YU43598A (sh) 1999-09-27
RU2171119C2 (ru) 2001-07-27
GB9607549D0 (en) 1996-06-12
ZA973011B (en) 1998-05-25

Similar Documents

Publication Publication Date Title
CN1220613A (zh) 医疗用弹力分送装置
US8343130B2 (en) Needleless injector
CN1217709C (zh) 具有两级注射速度的无针注射器
JP3718167B2 (ja) 充填済みアンプル内に入った液体を注入するための無針式シリンジ
CN1177305A (zh) 弹簧驱动的撒播装置
JP4125517B2 (ja) 一時的に保持される押し込み手段を有する無針注射器
US8287489B2 (en) Device for readying a needle free injector for delivery
KR20060108683A (ko) 습식/건식 자동 주사기 조립체
CN1188182C (zh) 由冲击管效应操作的、活性要素侧向预装的无针头注射器
EP1231961B1 (en) Injector assembly with driving means and locking means
HU226500B1 (en) Needleless syringe provided with modular reservoir
KR20040027899A (ko) 연료분사밸브
JP3759726B2 (ja) 薬液収容貯蔵器の圧迫によって働く針無注射器
KR100703258B1 (ko) 기둥
CN1276798C (zh) 流体制品分配设备
CN110769876A (zh) 注射器
JP3076820B1 (ja) 流動物圧入装置
JP2019505323A (ja) スライドする膜を有する無針注射装置
KR100489735B1 (ko) 고압 가스 주입 배출용 공압 이탈 밸브

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication