MX2016011517A - Peptidos de crmp2 no narcoticos que seleccionan como diana canales de sodio para el dolor cronico. - Google Patents

Peptidos de crmp2 no narcoticos que seleccionan como diana canales de sodio para el dolor cronico.

Info

Publication number
MX2016011517A
MX2016011517A MX2016011517A MX2016011517A MX2016011517A MX 2016011517 A MX2016011517 A MX 2016011517A MX 2016011517 A MX2016011517 A MX 2016011517A MX 2016011517 A MX2016011517 A MX 2016011517A MX 2016011517 A MX2016011517 A MX 2016011517A
Authority
MX
Mexico
Prior art keywords
crmp2
disclosed
chronic pain
narcotic
sodium channels
Prior art date
Application number
MX2016011517A
Other languages
English (en)
Inventor
Todd W Vanderah
Khanna Rajesh
KHANNA May
T Dustrude Erik
Original Assignee
Univ Arizona
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Arizona filed Critical Univ Arizona
Publication of MX2016011517A publication Critical patent/MX2016011517A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

En la presente se divulgan polipéptidos aislados capaces de prevenir el tráfico mediado por (SUMO) ilación de modificador tipo ubiquitina pequeño-proteína 2 mediadora de respuesta colapsante (CRMP2) de la función del canal de sodio cerrado al voltaje (Nav1.7). En algunos ejemplos, los péptidos divulgados comprenden tres a veinte aminoácidos e incluyen la secuencia de aminoácidos KMD. Igualmente se divulgan métodos para disminuir la nocicepción, que incluyen administrar una cantidad efectiva de uno o más de los péptidos divulgados a un sujeto en necesidad de ello, tal como un sujeto que experimenta dolor crónico.
MX2016011517A 2014-03-07 2015-03-06 Peptidos de crmp2 no narcoticos que seleccionan como diana canales de sodio para el dolor cronico. MX2016011517A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461949456P 2014-03-07 2014-03-07
PCT/US2015/019275 WO2015134920A1 (en) 2014-03-07 2015-03-06 Non-narcotic crmp2 peptides targeting sodium channels for chronic pain

Publications (1)

Publication Number Publication Date
MX2016011517A true MX2016011517A (es) 2017-04-13

Family

ID=54055921

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016011517A MX2016011517A (es) 2014-03-07 2015-03-06 Peptidos de crmp2 no narcoticos que seleccionan como diana canales de sodio para el dolor cronico.

Country Status (7)

Country Link
US (1) US10287334B2 (es)
EP (1) EP3119415A4 (es)
JP (1) JP6625071B2 (es)
AU (1) AU2015226911B2 (es)
CA (1) CA2941357A1 (es)
MX (1) MX2016011517A (es)
WO (1) WO2015134920A1 (es)

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CN113214362B (zh) * 2021-05-18 2022-06-21 湖南百尔泰克化妆品有限公司 一种对钠通道有抑制作用的多肽及其应用
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Also Published As

Publication number Publication date
JP2017515496A (ja) 2017-06-15
CA2941357A1 (en) 2015-09-11
WO2015134920A1 (en) 2015-09-11
AU2015226911A1 (en) 2016-10-27
US20170008939A1 (en) 2017-01-12
EP3119415A1 (en) 2017-01-25
US10287334B2 (en) 2019-05-14
EP3119415A4 (en) 2017-11-29
AU2015226911B2 (en) 2018-03-01
JP6625071B2 (ja) 2019-12-25

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