CN111328287A - 新型核酸分子 - Google Patents
新型核酸分子 Download PDFInfo
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- CN111328287A CN111328287A CN201880044741.6A CN201880044741A CN111328287A CN 111328287 A CN111328287 A CN 111328287A CN 201880044741 A CN201880044741 A CN 201880044741A CN 111328287 A CN111328287 A CN 111328287A
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y503/00—Intramolecular oxidoreductases (5.3)
- C12Y503/03—Intramolecular oxidoreductases (5.3) transposing C=C bonds (5.3.3)
- C12Y503/03012—L-Dopachrome isomerase (5.3.3.12)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/605—MHC molecules or ligands thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP2017/066676 | 2017-07-04 | ||
| EPPCT/EP2017/066676 | 2017-07-04 | ||
| PCT/EP2018/068015 WO2019008001A1 (en) | 2017-07-04 | 2018-07-03 | NEW NUCLEIC ACID MOLECULES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111328287A true CN111328287A (zh) | 2020-06-23 |
Family
ID=59384128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880044741.6A Pending CN111328287A (zh) | 2017-07-04 | 2018-07-03 | 新型核酸分子 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10988754B2 (enExample) |
| EP (3) | EP4494652A3 (enExample) |
| JP (2) | JP7722629B2 (enExample) |
| KR (1) | KR102761594B1 (enExample) |
| CN (1) | CN111328287A (enExample) |
| AU (1) | AU2018298422B2 (enExample) |
| BR (1) | BR112019028280A2 (enExample) |
| CA (1) | CA3066932A1 (enExample) |
| ES (1) | ES3013993T3 (enExample) |
| RU (1) | RU2020103379A (enExample) |
| SG (1) | SG11201911430PA (enExample) |
| WO (1) | WO2019008001A1 (enExample) |
Cited By (58)
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| CN108728477A (zh) * | 2017-04-24 | 2018-11-02 | 华东理工大学 | 一种高效的转座突变系统及构建方法 |
| CN110201187A (zh) * | 2011-12-16 | 2019-09-06 | 现代泰克斯公司 | 经修饰的核苷、核苷酸和核酸组合物 |
| CN111118011A (zh) * | 2020-02-11 | 2020-05-08 | 昆明医科大学 | 一种抑制hsa_circ_0027478表达的siRNA及其应用 |
| CN111647597A (zh) * | 2020-02-11 | 2020-09-11 | 昆明医科大学 | 一种抑制hsa_circ_0027479表达的siRNA及其应用 |
| CN111647598A (zh) * | 2020-02-11 | 2020-09-11 | 昆明医科大学 | 一种抑制hsa_circ_0027477表达的siRNA及其应用 |
| CN111733158A (zh) * | 2020-02-11 | 2020-10-02 | 昆明医科大学 | 一种抑制hsa_circ_0003599表达的siRNA及其应用 |
| CN111973745A (zh) * | 2020-09-08 | 2020-11-24 | 中国医科大学 | Bap18在乳腺癌内分泌治疗抵抗中的应用 |
| CN112011564A (zh) * | 2020-09-04 | 2020-12-01 | 西南大学 | 新型隐球菌细胞核指示载体及其构建方法和应用 |
| CN112050201A (zh) * | 2020-10-10 | 2020-12-08 | 清华大学 | 一种异型炉膛结构的湍动流化床焚烧炉 |
| CN112175062A (zh) * | 2019-07-05 | 2021-01-05 | 中国医学科学院基础医学研究所 | Sft2b蛋白线性抗原表位以及其在精神分裂症诊断中的用途 |
| CN112190719A (zh) * | 2020-10-19 | 2021-01-08 | 重庆大学 | 一种钙调控机制紊乱的动物模型在视网膜病变中的应用 |
| CN112362432A (zh) * | 2021-01-12 | 2021-02-12 | 广州科方生物技术股份有限公司 | 一种通用于血清中tt3和tt4的解离剂及其制备方法 |
| CN112574997A (zh) * | 2021-01-17 | 2021-03-30 | 昆明医科大学 | 一种fbxw7环状rna的改构体及其在肿瘤药物和新冠疫苗中的应用 |
| CN112575003A (zh) * | 2020-12-17 | 2021-03-30 | 中国农业科学院植物保护研究所 | 本氏烟hakai基因在调控植物抗病毒中的应用及转基因植物培育方法 |
| CN112574975A (zh) * | 2020-09-30 | 2021-03-30 | 华南理工大学 | 甘油酯脂肪酶突变体g28c-p206c及其编码基因与应用 |
| CN112630449A (zh) * | 2020-12-30 | 2021-04-09 | 广西壮族自治区水牛研究所 | 对水牛出生时间进行判断的血液外泌体标志物及其应用 |
| CN112679596A (zh) * | 2021-01-15 | 2021-04-20 | 武汉大学 | 一种内收蛋白的抗原肽及其抗体与应用 |
| CN112763714A (zh) * | 2020-12-31 | 2021-05-07 | 徐州市中心医院 | 一种用于肝癌诊断的生物标志物及其检测方法 |
| CN112794901A (zh) * | 2021-01-08 | 2021-05-14 | 南通大学附属医院 | 一种抗smim15单克隆抗体及其应用 |
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| CN114225035A (zh) * | 2020-09-09 | 2022-03-25 | 上海交通大学医学院 | 环状RNA Cwc27下调剂在制备预防和/或治疗阿尔茨海默病的药物中的应用 |
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| CN114384032A (zh) * | 2022-01-17 | 2022-04-22 | 云南大学 | 诺如病毒检测探针及其制备方法、诺如病毒检测试剂盒和非诊断目的检测诺如病毒的方法 |
| CN114561389A (zh) * | 2022-03-15 | 2022-05-31 | 南通市肿瘤医院 | Vrk1表达抑制剂及其应用 |
| CN114621962A (zh) * | 2022-03-21 | 2022-06-14 | 广西大学 | 花生AhBI-1基因VIGS沉默体系 |
| CN114702569A (zh) * | 2022-05-25 | 2022-07-05 | 深圳吉诺因生物科技有限公司 | Pd-l1相关疫苗及其应用 |
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| WO2025140126A1 (en) * | 2023-12-25 | 2025-07-03 | Everest Medicines (China) Co., Ltd. | Therapeutic ly6k mrna vaccine for cancer |
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Families Citing this family (120)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012019630A1 (en) | 2010-08-13 | 2012-02-16 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein |
| WO2012116714A1 (en) | 2011-03-02 | 2012-09-07 | Curevac Gmbh | Vaccination in elderly patients |
| WO2013120499A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly (a) sequence or a polyadenylation signal for increasing the expression of an encoded pathogenic antigen |
| SG10201710631RA (en) | 2012-03-27 | 2018-02-27 | Curevac Ag | Artificial nucleic acid molecules for improved protein or peptide expression |
| SG10201710473VA (en) | 2013-02-22 | 2018-02-27 | Curevac Ag | Combination of vaccination and inhibition of the pd-1 pathway |
| WO2015024668A2 (en) | 2013-08-21 | 2015-02-26 | Curevac Gmbh | Respiratory syncytial virus (rsv) vaccine |
| WO2015024669A1 (en) | 2013-08-21 | 2015-02-26 | Curevac Gmbh | Combination vaccine |
| RU2712743C2 (ru) | 2013-08-21 | 2020-01-30 | Куревак Аг | Вакцина против бешенства |
| US10307472B2 (en) | 2014-03-12 | 2019-06-04 | Curevac Ag | Combination of vaccination and OX40 agonists |
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| JP2020530980A (ja) | 2020-11-05 |
| JP2023123739A (ja) | 2023-09-05 |
| KR20200024905A (ko) | 2020-03-09 |
| RU2020103379A3 (enExample) | 2021-12-07 |
| EP4494652A2 (en) | 2025-01-22 |
| RU2020103379A (ru) | 2021-08-04 |
| CA3066932A1 (en) | 2019-01-10 |
| EP3648791A1 (en) | 2020-05-13 |
| US20210198649A1 (en) | 2021-07-01 |
| EP3424524A2 (en) | 2019-01-09 |
| JP7722629B2 (ja) | 2025-08-13 |
| WO2019008001A1 (en) | 2019-01-10 |
| AU2018298422B2 (en) | 2023-04-06 |
| US10988754B2 (en) | 2021-04-27 |
| BR112019028280A2 (pt) | 2020-07-14 |
| EP4494652A3 (en) | 2025-05-14 |
| EP3424524A3 (en) | 2019-02-27 |
| SG11201911430PA (en) | 2020-01-30 |
| US20190040378A1 (en) | 2019-02-07 |
| ES3013993T3 (en) | 2025-04-16 |
| KR102761594B1 (ko) | 2025-02-03 |
| EP3424524B1 (en) | 2024-12-11 |
| AU2018298422A1 (en) | 2019-12-19 |
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