US9228186B2
(en)
|
2002-11-14 |
2016-01-05 |
Thermo Fisher Scientific Inc. |
Methods and compositions for selecting siRNA of improved functionality
|
EP2365077B1
(en)
|
2004-03-12 |
2013-05-08 |
Alnylam Pharmaceuticals, Inc. |
iRNA agents targeting VEGF
|
NZ572666A
(en)
|
2006-05-11 |
2010-11-26 |
Alnylam Pharmaceuticals Inc |
Compositions comprising double stranded rna and methods for inhibiting expression of the pcsk9 gene
|
US8598333B2
(en)
*
|
2006-05-26 |
2013-12-03 |
Alnylam Pharmaceuticals, Inc. |
SiRNA silencing of genes expressed in cancer
|
WO2009134487A2
(en)
*
|
2008-01-31 |
2009-11-05 |
Alnylam Pharmaceuticals, Inc. |
Optimized methods for delivery of dsrna targeting the pcsk9 gene
|
CA2716793A1
(en)
|
2008-03-05 |
2009-09-11 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of eg5 and vegf genes
|
NZ588583A
(en)
|
2008-04-15 |
2012-08-31 |
Protiva Biotherapeutics Inc |
Novel lipid formulations for nucleic acid delivery
|
CA2739170A1
(en)
|
2008-09-25 |
2010-04-01 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of serum amyloid a gene
|
US8168775B2
(en)
|
2008-10-20 |
2012-05-01 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of transthyretin
|
CA2743139C
(en)
|
2008-11-10 |
2019-04-02 |
Alnylam Pharmaceuticals, Inc. |
Novel lipids and compositions for the delivery of therapeutics
|
CA2746514C
(en)
|
2008-12-10 |
2018-11-27 |
Alnylam Pharmaceuticals, Inc. |
Gnaq targeted dsrna compositions and methods for inhibiting expression
|
CN104922699B
(en)
*
|
2009-03-12 |
2020-07-24 |
阿尔尼拉姆医药品有限公司 |
Lipid formulated compositions and methods for inhibiting the expression of Eg5 and VEGF genes
|
US20100285112A1
(en)
*
|
2009-05-05 |
2010-11-11 |
Tatiana Novobrantseva |
Methods of delivering oligonucleotides to immune cells
|
TR201811076T4
(en)
*
|
2009-06-10 |
2018-08-27 |
Arbutus Biopharma Corp |
Improved lipid formulation.
|
EA201270019A1
(en)
*
|
2009-06-15 |
2012-06-29 |
Элнилэм Фармасьютикалз, Инк. |
BENTROVAL RNA INCLUDED IN LIPID COMPOSITION AND WHICH IS THE PCSK9 GENE
|
WO2010147992A1
(en)
|
2009-06-15 |
2010-12-23 |
Alnylam Pharmaceuticals, Inc. |
Methods for increasing efficacy of lipid formulated sirna
|
EP2449114B9
(en)
|
2009-07-01 |
2017-04-19 |
Protiva Biotherapeutics Inc. |
Novel lipid formulations for delivery of therapeutic agents to solid tumors
|
EP2464336A4
(en)
|
2009-08-14 |
2013-11-20 |
Alnylam Pharmaceuticals Inc |
Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus
|
US8859516B2
(en)
|
2009-09-15 |
2014-10-14 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of Eg5 and VEGF genes
|
HRP20220478T1
(en)
|
2009-09-22 |
2022-05-27 |
Medicago Inc. |
Method of preparing plant-derived proteins
|
US9187746B2
(en)
|
2009-09-22 |
2015-11-17 |
Alnylam Pharmaceuticals, Inc. |
Dual targeting siRNA agents
|
WO2011056883A1
(en)
*
|
2009-11-03 |
2011-05-12 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of transthyretin (ttr)
|
ME03327B
(en)
|
2009-12-01 |
2019-10-20 |
Translate Bio Inc |
Steroid derivative for the delivery of mrna in human genetic diseases
|
EP2512449B1
(en)
*
|
2009-12-18 |
2019-08-07 |
The University of British Columbia |
Methods and compositions for delivery of nucleic acids
|
WO2011088309A1
(en)
|
2010-01-14 |
2011-07-21 |
Regulus Therapeutics Inc. |
Microrna compositions and methods
|
CA2799091A1
(en)
|
2010-05-12 |
2011-11-17 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods of use thereof
|
WO2011141704A1
(en)
|
2010-05-12 |
2011-11-17 |
Protiva Biotherapeutics, Inc |
Novel cyclic cationic lipids and methods of use
|
US9006417B2
(en)
|
2010-06-30 |
2015-04-14 |
Protiva Biotherapeutics, Inc. |
Non-liposomal systems for nucleic acid delivery
|
WO2012006369A2
(en)
|
2010-07-06 |
2012-01-12 |
Novartis Ag |
Immunisation of large mammals with low doses of rna
|
EP2590626B1
(en)
|
2010-07-06 |
2015-10-28 |
GlaxoSmithKline Biologicals SA |
Liposomes with lipids having an advantageous pka-value for rna delivery
|
HUE047796T2
(en)
|
2010-07-06 |
2020-05-28 |
Glaxosmithkline Biologicals Sa |
Delivery of rna to trigger multiple immune pathways
|
US20130202652A1
(en)
*
|
2010-07-30 |
2013-08-08 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for delivery of active agents
|
US8822663B2
(en)
|
2010-08-06 |
2014-09-02 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
EP2606134B1
(en)
|
2010-08-17 |
2019-04-10 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
WO2012027467A1
(en)
|
2010-08-26 |
2012-03-01 |
Merck Sharp & Dohme Corp. |
RNA INTERFERENCE MEDIATED INHIBITION OF PROLYL HYDROXYLASE DOMAIN 2 (PHD2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
PL2611461T3
(en)
|
2010-08-31 |
2022-07-04 |
Glaxosmithkline Biologicals Sa |
Pegylated liposomes for delivery of immunogen-encoding rna
|
US8466122B2
(en)
|
2010-09-17 |
2013-06-18 |
Protiva Biotherapeutics, Inc. |
Trialkyl cationic lipids and methods of use thereof
|
MX349088B
(en)
|
2010-09-20 |
2017-07-10 |
Merck Sharp & Dohme |
Novel low molecular weight cationic lipids for oligonucleotide delivery.
|
PT3590949T
(en)
|
2010-10-01 |
2022-08-02 |
Modernatx Inc |
Ribonucleic acids containing n1-methyl-pseudouracils and uses thereof
|
KR102266691B1
(en)
|
2010-10-11 |
2021-06-23 |
노파르티스 아게 |
Antigen delivery platforms
|
CA2813024A1
(en)
|
2010-10-21 |
2012-04-26 |
Merck Sharp & Dohme Corp. |
Novel low molecular weight cationic lipids for oligonucleotide delivery
|
EP2632472B1
(en)
|
2010-10-29 |
2017-12-13 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of gene expression using short interfering nucleic acids (sina)
|
DK2635265T3
(en)
|
2010-11-05 |
2018-07-16 |
Sirna Therapeutics Inc |
New low molecular weight cyclic amine-containing cationic lipids for oligonucleotide delivery
|
US8853377B2
(en)
|
2010-11-30 |
2014-10-07 |
Shire Human Genetic Therapies, Inc. |
mRNA for use in treatment of human genetic diseases
|
TWI620816B
(en)
|
2011-03-23 |
2018-04-11 |
苜蓿股份有限公司 |
Method of recovering plant-derived proteins
|
US8710200B2
(en)
|
2011-03-31 |
2014-04-29 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids encoding a modified erythropoietin and their expression
|
WO2012151575A2
(en)
*
|
2011-05-05 |
2012-11-08 |
Duke University |
A method of controlling coagulation
|
EP2714971A4
(en)
*
|
2011-05-23 |
2015-01-21 |
Phylogica Ltd |
Method of determining, identifying or isolating cell-penetrating peptides
|
BR112013031553A2
(en)
|
2011-06-08 |
2020-11-10 |
Shire Human Genetic Therapies, Inc. |
compositions, mrna encoding a gland and its use, use of at least one mrna molecule and a vehicle for transfer and use of an mrna encoding for exogenous protein
|
US9068184B2
(en)
|
2011-06-21 |
2015-06-30 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibition of expression of protein C (PROC) genes
|
AU2012272860A1
(en)
*
|
2011-06-21 |
2013-12-19 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibition of expression of apolipoprotein C-III (APOC3) genes
|
MX360782B
(en)
|
2011-06-21 |
2018-11-16 |
Alnylam Pharmaceuticals Inc |
Angiopoietin-like 3 (angptl3) irna compostions and methods of use thereof.
|
US11896636B2
(en)
|
2011-07-06 |
2024-02-13 |
Glaxosmithkline Biologicals Sa |
Immunogenic combination compositions and uses thereof
|
WO2013033230A1
(en)
|
2011-08-29 |
2013-03-07 |
Isis Pharmaceuticals, Inc. |
Oligomer-conjugate complexes and their use
|
US9464124B2
(en)
|
2011-09-12 |
2016-10-11 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
SG11201401196WA
(en)
|
2011-10-03 |
2014-05-29 |
Moderna Therapeutics Inc |
Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
|
ES2800065T3
(en)
|
2011-11-18 |
2020-12-23 |
Alnylam Pharmaceuticals Inc |
IRNA Agents, Compositions, and Methods of Using The Same to Treat Transthyretin-Associated Diseases (TTR)
|
DK3988537T1
(en)
|
2011-12-07 |
2022-05-23 |
Alnylam Pharmaceuticals Inc |
BIODEGRADABLE LIPIDES FOR DELIVERY OF ACTIVE AGENTS
|
CA2856737C
(en)
*
|
2011-12-07 |
2023-09-26 |
Alnylam Pharmaceuticals, Inc. |
Branched alkyl and cycloalkyl terminated biodegradable lipids for the delivery of active agents
|
AU2012352180A1
(en)
|
2011-12-16 |
2014-07-31 |
Moderna Therapeutics, Inc. |
Modified nucleoside, nucleotide, and nucleic acid compositions
|
US9035039B2
(en)
|
2011-12-22 |
2015-05-19 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for silencing SMAD4
|
EP3473611B1
(en)
|
2012-02-24 |
2021-10-20 |
Arbutus Biopharma Corporation |
Trialkyl cationic lipids and methods of use thereof
|
US10501513B2
(en)
*
|
2012-04-02 |
2019-12-10 |
Modernatx, Inc. |
Modified polynucleotides for the production of oncology-related proteins and peptides
|
US10501512B2
(en)
|
2012-04-02 |
2019-12-10 |
Modernatx, Inc. |
Modified polynucleotides
|
US9572897B2
(en)
|
2012-04-02 |
2017-02-21 |
Modernatx, Inc. |
Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
|
EP3505176A1
(en)
|
2012-04-02 |
2019-07-03 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of secreted proteins
|
JP2015518705A
(en)
|
2012-04-02 |
2015-07-06 |
モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. |
Modified polynucleotides for the production of biologics and proteins associated with human diseases
|
US9283287B2
(en)
|
2012-04-02 |
2016-03-15 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of nuclear proteins
|
JP6232416B2
(en)
|
2012-04-19 |
2017-11-15 |
サーナ・セラピューティクス・インコーポレイテッドSirna Therapeutics,Inc. |
Novel diester and triester-based low molecular weight, biodegradable cationic lipids for oligonucleotide delivery
|
US9127274B2
(en)
|
2012-04-26 |
2015-09-08 |
Alnylam Pharmaceuticals, Inc. |
Serpinc1 iRNA compositions and methods of use thereof
|
US9334498B2
(en)
|
2012-05-10 |
2016-05-10 |
Uab Research Foundation |
Methods and compositions for modulating MIR-204 activity
|
MX2014015041A
(en)
|
2012-06-08 |
2015-06-17 |
Shire Human Genetic Therapies |
Pulmonary delivery of mrna to non-lung target cells.
|
EP3536787A1
(en)
|
2012-06-08 |
2019-09-11 |
Translate Bio, Inc. |
Nuclease resistant polynucleotides and uses thereof
|
US9415109B2
(en)
|
2012-07-06 |
2016-08-16 |
Alnylam Pharmaceuticals, Inc. |
Stable non-aggregating nucleic acid lipid particle formulations
|
US9512456B2
(en)
|
2012-08-14 |
2016-12-06 |
Modernatx, Inc. |
Enzymes and polymerases for the synthesis of RNA
|
US20140120157A1
(en)
*
|
2012-09-19 |
2014-05-01 |
Georgetown University |
Targeted liposomes
|
JP6144355B2
(en)
|
2012-11-26 |
2017-06-07 |
モデルナティエックス インコーポレイテッドModernaTX,Inc. |
Chemically modified mRNA
|
ES2657608T3
(en)
|
2012-12-05 |
2018-03-06 |
Alnylam Pharmaceuticals, Inc. |
Compositions of pcsk9 arni and methods of use thereof
|
AU2013355258A1
(en)
*
|
2012-12-07 |
2015-06-11 |
Alnylam Pharmaceuticals, Inc. |
Improved nucleic acid lipid particle formulations
|
CA2897941A1
(en)
|
2013-01-17 |
2014-07-24 |
Moderna Therapeutics, Inc. |
Signal-sensor polynucleotides for the alteration of cellular phenotypes
|
CA2888286C
(en)
*
|
2013-03-06 |
2020-03-24 |
Biomics Biotechnologies Co., Ltd. |
Liposome formulation, its preparation and application
|
US20160024181A1
(en)
*
|
2013-03-13 |
2016-01-28 |
Moderna Therapeutics, Inc. |
Long-lived polynucleotide molecules
|
AU2014236305B2
(en)
|
2013-03-14 |
2019-01-17 |
Ethris Gmbh |
CFTR mRNA compositions and related methods and uses
|
HUE055044T2
(en)
|
2013-03-14 |
2021-10-28 |
Translate Bio Inc |
Methods and compositions for delivering mrna coded antibodies
|
RS56663B1
(en)
|
2013-03-14 |
2018-03-30 |
Alnylam Pharmaceuticals Inc |
Complement component c5 irna compositions and methods of use thereof
|
KR20150128687A
(en)
|
2013-03-14 |
2015-11-18 |
샤이어 휴먼 지네틱 테라피즈 인크. |
Methods for purification of messenger rna
|
WO2014152211A1
(en)
|
2013-03-14 |
2014-09-25 |
Moderna Therapeutics, Inc. |
Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
|
EP2971161B1
(en)
|
2013-03-15 |
2018-12-26 |
ModernaTX, Inc. |
Ribonucleic acid purification
|
US8980864B2
(en)
|
2013-03-15 |
2015-03-17 |
Moderna Therapeutics, Inc. |
Compositions and methods of altering cholesterol levels
|
US10272041B2
(en)
*
|
2013-03-15 |
2019-04-30 |
The Penn State Research Foundation |
Acid stable liposomal compositions and methods for producing the same
|
EP2983804A4
(en)
|
2013-03-15 |
2017-03-01 |
Moderna Therapeutics, Inc. |
Ion exchange purification of mrna
|
ES2670529T3
(en)
|
2013-03-15 |
2018-05-30 |
Translate Bio, Inc. |
Synergistic improvement of nucleic acid delivery through mixed formulations
|
JP6605446B2
(en)
*
|
2013-03-15 |
2019-11-13 |
ザ ユニバーシティ オブ ブリティッシュ コロンビア |
Lipid nanoparticles and related methods for transfection
|
CN105378085B
(en)
|
2013-05-01 |
2019-02-15 |
Ionis制药公司 |
For adjusting the composition and method of HBV and TTR expression
|
US10246708B2
(en)
|
2013-05-06 |
2019-04-02 |
Alnylam Pharmaceuticals, Inc. |
Dosages and methods for delivering lipid formulated nucleic acid molecules
|
AU2014268529C1
(en)
|
2013-05-22 |
2020-10-01 |
Alnylam Pharmaceuticals, Inc. |
TMPRSS6 iRNA compositions and methods of use thereof
|
SG10201804472YA
(en)
|
2013-05-22 |
2018-07-30 |
Alnylam Pharmaceuticals Inc |
SERPINA1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
HUE056760T2
(en)
|
2013-07-11 |
2022-03-28 |
Modernatx Inc |
Compositions comprising synthetic polynucleotides encoding crispr related proteins and synthetic sgrnas and methods of use
|
CN105555757A
(en)
|
2013-07-23 |
2016-05-04 |
普洛体维生物治疗公司 |
Compositions and methods for delivering messenger RNA
|
US20160194368A1
(en)
|
2013-09-03 |
2016-07-07 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
WO2015034928A1
(en)
|
2013-09-03 |
2015-03-12 |
Moderna Therapeutics, Inc. |
Chimeric polynucleotides
|
US10195291B2
(en)
*
|
2013-09-24 |
2019-02-05 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for the manufacture of lipid nanoparticles
|
US10023626B2
(en)
|
2013-09-30 |
2018-07-17 |
Modernatx, Inc. |
Polynucleotides encoding immune modulating polypeptides
|
US10385088B2
(en)
|
2013-10-02 |
2019-08-20 |
Modernatx, Inc. |
Polynucleotide molecules and uses thereof
|
WO2015051214A1
(en)
|
2013-10-03 |
2015-04-09 |
Moderna Therapeutics, Inc. |
Polynucleotides encoding low density lipoprotein receptor
|
EA201690576A1
(en)
|
2013-10-22 |
2016-10-31 |
Шир Хьюман Дженетик Терапис, Инк. |
LIPID COMPOSITIONS FOR DELIVERY OF MATRIX RNA
|
EA034103B1
(en)
|
2013-10-22 |
2019-12-27 |
Транслейт Био, Инк. |
METHOD OF TREATING PHENYLKETONURIA USING mRNA
|
WO2015061461A1
(en)
|
2013-10-22 |
2015-04-30 |
Shire Human Genetic Therapies, Inc. |
Cns delivery of mrna and uses thereof
|
WO2015061500A1
(en)
|
2013-10-22 |
2015-04-30 |
Shire Human Genetic Therapies, Inc. |
Mrna therapy for argininosuccinate synthetase deficiency
|
KR102095085B1
(en)
|
2013-11-18 |
2020-03-31 |
아크투루스 쎄라퓨틱스, 인크. |
ionizable cationic lipid for rna delivery
|
CA2930973A1
(en)
|
2013-11-22 |
2015-05-28 |
Pal SAERTROM |
C/ebp alpha short activating rna compositions and methods of use
|
CA3107872A1
(en)
|
2013-12-12 |
2015-06-18 |
Alnylam Pharmaceuticals, Inc. |
Complement component irna compositions and methods of use thereof
|
US9873669B2
(en)
|
2014-01-09 |
2018-01-23 |
Eisai R&D Management Co., Ltd. |
Cationic lipid
|
EP3960860A3
(en)
|
2014-02-11 |
2022-06-08 |
Alnylam Pharmaceuticals, Inc. |
Ketohexokinase (khk) irna compositions and methods of use thereof
|
EP3110401A4
(en)
|
2014-02-25 |
2017-10-25 |
Merck Sharp & Dohme Corp. |
Lipid nanoparticle vaccine adjuvants and antigen delivery systems
|
SG10201912038TA
(en)
|
2014-04-23 |
2020-02-27 |
Modernatx Inc |
Nucleic acid vaccines
|
CN117402871A
(en)
|
2014-04-25 |
2024-01-16 |
川斯勒佰尔公司 |
Method for purifying messenger RNA
|
EP3137476B1
(en)
|
2014-04-28 |
2019-10-09 |
Ionis Pharmaceuticals, Inc. |
Linkage modified oligomeric compounds
|
ES2849600T3
(en)
|
2014-05-01 |
2021-08-19 |
Ionis Pharmaceuticals Inc |
Modified antisense oligonucleotide conjugates and their use to modulate PKK expression
|
PE20190626A1
(en)
|
2014-05-01 |
2019-04-26 |
Ionis Pharmaceuticals Inc |
COMPOSITIONS AND METHODS TO MODULATE THE EXPRESSION OF FACTOR B OF THE COMPLEMENT
|
MX2016014102A
(en)
|
2014-05-01 |
2017-05-03 |
Ionis Pharmaceuticals Inc |
Compositions and methods for modulating angiopoietin-like 3 expression.
|
CN106459969B
(en)
|
2014-05-01 |
2019-11-15 |
Ionis制药公司 |
For adjusting the composition and method of growth hormone receptor expression
|
EP3137899A2
(en)
|
2014-05-02 |
2017-03-08 |
Cerenis Therapeutics Holding SA |
Hdl therapy markers
|
CN112852809A
(en)
|
2014-05-22 |
2021-05-28 |
阿尔尼拉姆医药品有限公司 |
Angiotensinogen (AGT) iRNA compositions and methods of use thereof
|
WO2015179693A1
(en)
|
2014-05-22 |
2015-11-26 |
Isis Pharmaceuticals, Inc. |
Conjugated antisense compounds and their use
|
JP6557722B2
(en)
|
2014-05-30 |
2019-08-07 |
シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド |
Biodegradable lipids for delivery of nucleic acids
|
WO2015188194A1
(en)
*
|
2014-06-06 |
2015-12-10 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for enhanced intestinal absorption of conjugated oligomeric compounds
|
AU2015279968B2
(en)
|
2014-06-24 |
2019-11-14 |
Translate Bio, Inc. |
Stereochemically enriched compositions for delivery of nucleic acids
|
ES2931832T3
(en)
|
2014-06-25 |
2023-01-03 |
Acuitas Therapeutics Inc |
Novel lipids and lipid nanoparticle formulations for nucleic acid delivery
|
BR112016030852A2
(en)
|
2014-07-02 |
2018-01-16 |
Shire Human Genetic Therapies |
rna messenger encapsulation
|
EP3169693B1
(en)
|
2014-07-16 |
2022-03-09 |
ModernaTX, Inc. |
Chimeric polynucleotides
|
EP3171895A1
(en)
|
2014-07-23 |
2017-05-31 |
Modernatx, Inc. |
Modified polynucleotides for the production of intrabodies
|
WO2016033326A2
(en)
|
2014-08-29 |
2016-03-03 |
Alnylam Pharmaceuticals, Inc. |
Methods of treating transthyretin (ttr) mediated amyloidosis
|
EP3191591A1
(en)
|
2014-09-12 |
2017-07-19 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting complement component c5 and methods of use thereof
|
JOP20200115A1
(en)
|
2014-10-10 |
2017-06-16 |
Alnylam Pharmaceuticals Inc |
Compositions And Methods For Inhibition Of HAO1 (Hydroxyacid Oxidase 1 (Glycolate Oxidase)) Gene Expression
|
WO2016061487A1
(en)
|
2014-10-17 |
2016-04-21 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting aminolevulinic acid synthase-1 (alas1) and uses thereof
|
WO2016065349A2
(en)
|
2014-10-24 |
2016-04-28 |
University Of Maryland, Baltimore |
Short non-coding protein regulatory rnas (sprrnas) and methods of use
|
EP3904519A1
(en)
|
2014-10-30 |
2021-11-03 |
Genzyme Corporation |
Polynucleotide agents targeting serpinc1 (at3) and methods of use thereof
|
JOP20200092A1
(en)
|
2014-11-10 |
2017-06-16 |
Alnylam Pharmaceuticals Inc |
HEPATITIS B VIRUS (HBV) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
CA2968114A1
(en)
|
2014-11-17 |
2016-05-26 |
Alnylam Pharmaceuticals, Inc. |
Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof
|
JP6767976B2
(en)
|
2014-12-05 |
2020-10-14 |
トランスレイト バイオ, インコーポレイテッド |
Messenger RNA therapy for the treatment of joint diseases
|
AU2015364508A1
(en)
*
|
2014-12-18 |
2017-07-06 |
Alnylam Pharmaceuticals, Inc. |
ReversirTM compounds
|
JP6592458B2
(en)
|
2014-12-26 |
2019-10-16 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
Cationic lipid
|
EP3256587A2
(en)
|
2015-02-13 |
2017-12-20 |
Alnylam Pharmaceuticals, Inc. |
Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
|
WO2016149508A1
(en)
|
2015-03-19 |
2016-09-22 |
Shire Human Genetic Therapies, Inc. |
Mrna therapy for pompe disease
|
MX2017012610A
(en)
|
2015-04-08 |
2018-03-16 |
Alnylam Pharmaceuticals Inc |
Compositions and methods for inhibiting expression of the lect2 gene.
|
WO2016168286A1
(en)
|
2015-04-13 |
2016-10-20 |
Alnylam Pharmaceuticals, Inc. |
Angiopoietin-like 3 (angptl3) irna compositions and methods of use thereof
|
US10660973B2
(en)
|
2015-04-28 |
2020-05-26 |
Duke University |
Thrombus imaging aptamers and methods of using same
|
TWI727948B
(en)
|
2015-05-06 |
2021-05-21 |
美商阿尼拉製藥公司 |
FACTOR XII (HAGEMAN FACTOR) (F12), KALLIKREIN B, PLASMA (FLETCHER FACTOR) 1 (KLKB1), AND KININOGEN 1 (KNG1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
EP3307316A1
(en)
|
2015-06-12 |
2018-04-18 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions and methods of use thereof
|
WO2016205323A1
(en)
|
2015-06-18 |
2016-12-22 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotde agents targeting hydroxyacid oxidase (glycolate oxidase, hao1) and methods of use thereof
|
WO2016209862A1
(en)
|
2015-06-23 |
2016-12-29 |
Alnylam Pharmaceuticals, Inc. |
Glucokinase (gck) irna compositions and methods of use thereof
|
US10221127B2
(en)
|
2015-06-29 |
2019-03-05 |
Acuitas Therapeutics, Inc. |
Lipids and lipid nanoparticle formulations for delivery of nucleic acids
|
CN109477106B
(en)
|
2015-07-10 |
2022-10-04 |
Ionis制药公司 |
Modulators of diacylglycerol acyltransferase 2 (DGAT 2)
|
WO2017011286A1
(en)
|
2015-07-10 |
2017-01-19 |
Alnylam Pharmaceuticals, Inc. |
Insulin-like growth factor binding protein, acid labile subunit (igfals) and insulin-like growth factor 1 (igf-1) irna compositions and methods of use thereof
|
CA2993350C
(en)
|
2015-07-31 |
2022-04-05 |
Arcturus Therapeutics, Inc. |
Multiligand agent for drug delivery
|
EP3329002B1
(en)
|
2015-07-31 |
2020-10-07 |
Alnylam Pharmaceuticals, Inc. |
Transthyretin (ttr) irna compositions and methods of use thereof for treating or preventing ttr-associated diseases
|
US11564893B2
(en)
|
2015-08-17 |
2023-01-31 |
Modernatx, Inc. |
Methods for preparing particles and related compositions
|
EP3344769B1
(en)
|
2015-09-02 |
2024-04-17 |
Alnylam Pharmaceuticals, Inc. |
Programmed cell death 1 ligand 1 (pd-l1) irna compositions and methods of use thereof
|
EP3350328A1
(en)
|
2015-09-14 |
2018-07-25 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting patatin-like phospholipase domain containing 3 (pnpla3) and methods of use thereof
|
EP4286012A2
(en)
|
2015-09-17 |
2023-12-06 |
ModernaTX, Inc. |
Compounds and compositions for intracellular delivery of therapeutic agents
|
JP6877414B2
(en)
|
2015-09-24 |
2021-05-26 |
アイオニス・ファーマシューティカルズ・インコーポレイテッドIonis Pharmaceuticals,Inc. |
KRAS expression modulator
|
CN108136041B
(en)
|
2015-10-02 |
2022-12-30 |
罗氏创新中心哥本哈根有限公司 |
Oligonucleotide conjugation methods
|
US10849920B2
(en)
|
2015-10-05 |
2020-12-01 |
Modernatx, Inc. |
Methods for therapeutic administration of messenger ribonucleic acid drugs
|
WO2017066573A1
(en)
|
2015-10-14 |
2017-04-20 |
Shire Human Genetic Therapies, Inc. |
Modification of rna-related enzymes for enhanced production
|
ES2922760T3
(en)
|
2015-10-22 |
2022-09-20 |
Modernatx Inc |
Respiratory virus vaccines
|
HUE061564T2
(en)
|
2015-10-28 |
2023-07-28 |
Acuitas Therapeutics Inc |
Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids
|
WO2017079745A1
(en)
|
2015-11-06 |
2017-05-11 |
Ionis Pharmaceuticals, Inc. |
Conjugated antisense compounds for use in therapy
|
US10557137B2
(en)
|
2015-11-06 |
2020-02-11 |
Ionis Pharmaceuticals, Inc. |
Modulating apolipoprotein (a) expression
|
EP3868890A1
(en)
|
2015-11-18 |
2021-08-25 |
Provivi, Inc. |
Microorganisms for the production of insect pheromones and related compounds
|
SG11201804729RA
(en)
|
2015-12-07 |
2018-07-30 |
Genzyme Corp |
Methods and compositions for treating a serpinc1-associated disorder
|
JP2018536689A
(en)
|
2015-12-10 |
2018-12-13 |
アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
Sterol regulatory element binding protein (SREBP) chaperone (SCAP) iRNA compositions and methods of use thereof
|
JP7080172B2
(en)
|
2015-12-10 |
2022-06-03 |
モデルナティエックス インコーポレイテッド |
Compositions and Methods for Delivery of Therapeutic Agents
|
EP4036079A3
(en)
|
2015-12-22 |
2022-09-28 |
ModernaTX, Inc. |
Compounds and compositions for intracellular delivery of agents
|
EP4039699A1
(en)
|
2015-12-23 |
2022-08-10 |
ModernaTX, Inc. |
Methods of using ox40 ligand encoding polynucleotides
|
EP3400023A1
(en)
|
2016-01-10 |
2018-11-14 |
ModernaTX, Inc. |
Therapeutic mrnas encoding anti ctla-4 antibodies
|
EP3405579A1
(en)
|
2016-01-22 |
2018-11-28 |
Modernatx, Inc. |
Messenger ribonucleic acids for the production of intracellular binding polypeptides and methods of use thereof
|
HRP20211697T1
(en)
|
2016-03-03 |
2022-02-04 |
University Of Massachusetts |
Closed-ended linear duplex dna for non-viral gene transfer
|
CN113797348A
(en)
|
2016-03-07 |
2021-12-17 |
箭头药业股份有限公司 |
Targeting ligands for therapeutic compounds
|
KR102369898B1
(en)
|
2016-04-08 |
2022-03-03 |
트랜슬레이트 바이오 인코포레이티드 |
Multimeric Encoding Nucleic Acids and Uses Thereof
|
EP3442590A2
(en)
|
2016-04-13 |
2019-02-20 |
Modernatx, Inc. |
Lipid compositions and their uses for intratumoral polynucleotide delivery
|
MA45295A
(en)
|
2016-04-19 |
2019-02-27 |
Alnylam Pharmaceuticals Inc |
HIGH DENSITY LIPOPROTEIN BINDING PROTEIN (HDLBP / VIGILINE) RNA COMPOSITION AND METHODS FOR USING THEM
|
JP7066632B2
(en)
*
|
2016-05-09 |
2022-05-13 |
アストラゼネカ・アクチエボラーグ |
Lipid nanoparticles containing lipophilic anti-inflammatory agents and how to use them
|
AU2017266932B2
(en)
|
2016-05-18 |
2023-04-20 |
Modernatx, Inc. |
Polynucleotides encoding alpha-galactosidase A for the treatment of Fabry disease
|
CA3024500A1
(en)
|
2016-05-18 |
2017-11-23 |
Modernatx, Inc. |
Polynucleotides encoding relaxin
|
WO2017201332A1
(en)
|
2016-05-18 |
2017-11-23 |
Modernatx, Inc. |
Polynucleotides encoding acyl-coa dehydrogenase, very long-chain for the treatment of very long-chain acyl-coa dehydrogenase deficiency
|
MA45036A
(en)
|
2016-05-18 |
2019-03-27 |
Modernatx Inc |
POLYNUCLEOTIDES CODING CITRINE FOR THE TREATMENT OF CITRULLINEMIA TYPE 2
|
EP3458083B1
(en)
|
2016-05-18 |
2022-11-02 |
ModernaTX, Inc. |
Polynucleotides encoding interleukin-12 (il12) and uses thereof
|
AR110606A1
(en)
|
2016-06-06 |
2019-04-17 |
Provivi Inc |
SEMI-BIOSYNTHETIC PRODUCTION OF FATTY ALCOHOLS AND FAT ALDEHYDES
|
EP3469083A1
(en)
|
2016-06-10 |
2019-04-17 |
Alnylam Pharmaceuticals, Inc. |
COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)
|
CN109312313A
(en)
|
2016-06-13 |
2019-02-05 |
川斯勒佰尔公司 |
For treating the mRNA therapy of ornithine transcarbamylase deficiency disease
|
BR112018075123A2
(en)
|
2016-06-24 |
2019-06-18 |
Eisai R&D Man Co Ltd |
cationic lipid
|
AU2017286980B2
(en)
|
2016-06-30 |
2023-10-26 |
Arbutus Biopharma Corporation |
Compositions and methods for delivering messenger RNA
|
PT3484524T
(en)
|
2016-07-15 |
2023-02-15 |
Ionis Pharmaceuticals Inc |
Compounds and methods for modulation of smn2
|
GB201614120D0
(en)
*
|
2016-08-18 |
2016-10-05 |
Univ Of Kwazulu-Natal |
pH-responsive lipids
|
SG11201811432WA
(en)
|
2016-08-19 |
2019-03-28 |
Curevac Ag |
Rna for cancer therapy
|
WO2018041921A1
(en)
|
2016-08-31 |
2018-03-08 |
Curevac Ag |
Mixing device for the production of a liquid nucleic acid composition
|
KR102493872B1
(en)
|
2016-09-02 |
2023-01-30 |
다이서나 파마수이티컬, 인크. |
4´-phosphate analogs and oligonucleotides comprising the same
|
KR102403408B1
(en)
|
2016-09-02 |
2022-05-30 |
애로우헤드 파마슈티컬스 인코포레이티드 |
targeting ligand
|
EP3432916B1
(en)
|
2016-09-13 |
2019-08-14 |
Allergan, Inc. |
Stabilized non-protein clostridial toxin compositions
|
WO2018053427A1
(en)
|
2016-09-16 |
2018-03-22 |
Duke University |
Von willebrand factor (vwf)-targeting agents and methods of using the same
|
EP3519578B1
(en)
|
2016-10-03 |
2021-12-22 |
Precision Nanosystems Inc |
Compositions for transfecting resistant cell types
|
WO2018067900A1
(en)
|
2016-10-06 |
2018-04-12 |
Ionis Pharmaceuticals, Inc. |
Method of conjugating oligomeric compounds
|
MX2019004810A
(en)
|
2016-10-26 |
2019-10-15 |
Modernatx Inc |
Messenger ribonucleic acids for enhancing immune responses and methods of use thereof.
|
US11583504B2
(en)
|
2016-11-08 |
2023-02-21 |
Modernatx, Inc. |
Stabilized formulations of lipid nanoparticles
|
TWI788312B
(en)
|
2016-11-23 |
2023-01-01 |
美商阿尼拉製藥公司 |
SERPINA1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
WO2018104540A1
(en)
|
2016-12-08 |
2018-06-14 |
Curevac Ag |
Rnas for wound healing
|
US11464836B2
(en)
|
2016-12-08 |
2022-10-11 |
Curevac Ag |
RNA for treatment or prophylaxis of a liver disease
|
WO2018112320A1
(en)
|
2016-12-16 |
2018-06-21 |
Alnylam Pharmaceuticals, Inc. |
Methods for treating or preventing ttr-associated diseases using transthyretin (ttr) irna compositions
|
US10526284B2
(en)
|
2016-12-21 |
2020-01-07 |
Arcturus Therapeutics, Inc. |
Ionizable cationic lipid for RNA delivery
|
US10383952B2
(en)
|
2016-12-21 |
2019-08-20 |
Arcturus Therapeutics, Inc. |
Ionizable cationic lipid for RNA delivery
|
EP3558354A1
(en)
|
2016-12-23 |
2019-10-30 |
CureVac AG |
Lassa virus vaccine
|
EP3558356A2
(en)
|
2016-12-23 |
2019-10-30 |
CureVac AG |
Mers coronavirus vaccine
|
WO2018115507A2
(en)
|
2016-12-23 |
2018-06-28 |
Curevac Ag |
Henipavirus vaccine
|
JP2020514321A
(en)
|
2017-02-01 |
2020-05-21 |
モデルナティーエックス, インコーポレイテッド |
Immunomodulatory therapeutic mRNA composition encoding an activated oncogene variant peptide
|
WO2018146506A1
(en)
*
|
2017-02-10 |
2018-08-16 |
Universitat Politècnica De València |
Therapeutic derivatives
|
WO2018157154A2
(en)
|
2017-02-27 |
2018-08-30 |
Translate Bio, Inc. |
Novel codon-optimized cftr mrna
|
PT3596041T
(en)
|
2017-03-15 |
2023-02-28 |
Modernatx Inc |
Compounds and compositions for intracellular delivery of therapeutic agents
|
US11203569B2
(en)
|
2017-03-15 |
2021-12-21 |
Modernatx, Inc. |
Crystal forms of amino lipids
|
US20200085944A1
(en)
|
2017-03-17 |
2020-03-19 |
Curevac Ag |
Rna vaccine and immune checkpoint inhibitors for combined anticancer therapy
|
JOP20190215A1
(en)
|
2017-03-24 |
2019-09-19 |
Ionis Pharmaceuticals Inc |
Modulators of pcsk9 expression
|
EP3601576A1
(en)
|
2017-03-24 |
2020-02-05 |
CureVac AG |
Nucleic acids encoding crispr-associated proteins and uses thereof
|
US11905525B2
(en)
|
2017-04-05 |
2024-02-20 |
Modernatx, Inc. |
Reduction of elimination of immune responses to non-intravenous, e.g., subcutaneously administered therapeutic proteins
|
WO2018191657A1
(en)
|
2017-04-13 |
2018-10-18 |
Acuitas Therapeutics, Inc. |
Lipids for delivery of active agents
|
BR112019021852A2
(en)
|
2017-04-18 |
2020-06-02 |
Alnylam Pharmaceuticals, Inc. |
RNAI AGENT AND A VACCINE AGAINST HBV, USE OR METHOD AND KIT FOR TREATMENT
|
AU2018256877B2
(en)
|
2017-04-28 |
2022-06-02 |
Acuitas Therapeutics, Inc. |
Novel carbonyl lipids and lipid nanoparticle formulations for delivery of nucleic acids
|
AU2018268859A1
(en)
|
2017-05-16 |
2019-12-12 |
Translate Bio, Inc. |
Treatment of cystic fibrosis by delivery of codon-optimized mrna encoding CFTR
|
EP3635124A4
(en)
|
2017-05-17 |
2021-03-31 |
Provivi, Inc. |
Microorganisms for the production of insect pheromones and related compounds
|
EP3625363A1
(en)
|
2017-05-17 |
2020-03-25 |
CureVac Real Estate GmbH |
Method for determining at least one quality parameter of an rna sample
|
US11485972B2
(en)
|
2017-05-18 |
2022-11-01 |
Modernatx, Inc. |
Modified messenger RNA comprising functional RNA elements
|
WO2018213731A1
(en)
|
2017-05-18 |
2018-11-22 |
Modernatx, Inc. |
Polynucleotides encoding tethered interleukin-12 (il12) polypeptides and uses thereof
|
WO2018222925A1
(en)
|
2017-05-31 |
2018-12-06 |
Ultragenyx Pharmaceutical Inc. |
Therapeutics for phenylketonuria
|
US11377643B2
(en)
|
2017-05-31 |
2022-07-05 |
Ultragenyx Pharmaceutical Inc. |
Therapeutics for glycogen storage disease type III
|
EP3630985A4
(en)
|
2017-05-31 |
2021-06-09 |
Arcturus Therapeutics, Inc. |
Synthesis and structure of high potency rna therapeutics
|
WO2018226841A1
(en)
*
|
2017-06-06 |
2018-12-13 |
Wayne State University |
Methods and compositions relating to carnitine- derived materials
|
CN109030429B
(en)
*
|
2017-06-09 |
2022-06-21 |
南京大学 |
Nano-amplification self-reference probe capable of carrying out in-situ imaging on microRNA21 in living cells
|
EP3638292A1
(en)
|
2017-06-14 |
2020-04-22 |
ModernaTX, Inc. |
Polynucleotides encoding coagulation factor viii
|
US20200131498A1
(en)
|
2017-06-14 |
2020-04-30 |
Modernatx, Inc. |
Polynucleotides encoding methylmalonyl-coa mutase
|
US11786607B2
(en)
|
2017-06-15 |
2023-10-17 |
Modernatx, Inc. |
RNA formulations
|
US10780183B2
(en)
|
2017-06-19 |
2020-09-22 |
Translate Bio, Inc. |
Messenger RNA therapy for the treatment of Friedreich's ataxia
|
CN111328287A
(en)
|
2017-07-04 |
2020-06-23 |
库瑞瓦格股份公司 |
Novel nucleic acid molecules
|
CA3069868A1
(en)
|
2017-07-13 |
2019-01-17 |
Alnylam Pharmaceuticals Inc. |
Lactate dehydrogenase a (ldha) irna compositions and methods of use thereof
|
EP3668833A1
(en)
|
2017-08-16 |
2020-06-24 |
Acuitas Therapeutics, Inc. |
Lipids for use in lipid nanoparticle formulations
|
WO2019036030A1
(en)
|
2017-08-17 |
2019-02-21 |
Acuitas Therapeutics, Inc. |
Lipids for use in lipid nanoparticle formulations
|
US11542225B2
(en)
|
2017-08-17 |
2023-01-03 |
Acuitas Therapeutics, Inc. |
Lipids for use in lipid nanoparticle formulations
|
MA50751A
(en)
|
2017-08-18 |
2020-06-24 |
Modernatx Inc |
EFFECTIVE RNA-BASED VACCINES
|
EP3673069A1
(en)
|
2017-08-22 |
2020-07-01 |
CureVac AG |
Bunyavirales vaccine
|
US11744801B2
(en)
|
2017-08-31 |
2023-09-05 |
Modernatx, Inc. |
Methods of making lipid nanoparticles
|
WO2019048645A1
(en)
|
2017-09-08 |
2019-03-14 |
Mina Therapeutics Limited |
Stabilized cebpa sarna compositions and methods of use
|
US11162099B2
(en)
|
2017-09-08 |
2021-11-02 |
Mina Therapeutics Limited |
HNF4A saRNA compositions and methods of use
|
KR20200089656A
(en)
|
2017-09-19 |
2020-07-27 |
알닐람 파마슈티칼스 인코포레이티드 |
Compositions and methods for treating transthyretin (TTR) mediated amyloidosis
|
KR20200071081A
(en)
|
2017-10-19 |
2020-06-18 |
큐어백 아게 |
New artificial nucleic acid molecule
|
WO2019089922A1
(en)
|
2017-11-01 |
2019-05-09 |
Alnylam Pharmaceuticals, Inc. |
Complement component c3 irna compositions and methods of use thereof
|
SG11202003247RA
(en)
|
2017-11-08 |
2020-05-28 |
Curevac Ag |
Rna sequence adaptation
|
WO2019094702A1
(en)
|
2017-11-10 |
2019-05-16 |
Cocoon Biotech Inc. |
Ocular applications of silk-based products
|
EP3710587A1
(en)
|
2017-11-16 |
2020-09-23 |
Alnylam Pharmaceuticals, Inc. |
Kisspeptin 1 (kiss1) irna compositions and methods of use thereof
|
WO2019100039A1
(en)
|
2017-11-20 |
2019-05-23 |
Alnylam Pharmaceuticals, Inc. |
Serum amyloid p component (apcs) irna compositions and methods of use thereof
|
JP7423522B2
(en)
|
2017-11-22 |
2024-01-29 |
モダーナティエックス・インコーポレイテッド |
Polynucleotide encoding ornithine transcarbamylase for the treatment of urea cycle disorders
|
EP3714252B1
(en)
|
2017-11-22 |
2023-05-31 |
Beckman Coulter, Inc. |
Diluent preparation module und method for supplying such diluent
|
CA3079543A1
(en)
|
2017-11-22 |
2019-05-31 |
Modernatx, Inc. |
Polynucleotides encoding propionyl-coa carboxylase alpha and beta subunits for the treatment of propionic acidemia
|
MA50801A
(en)
|
2017-11-22 |
2020-09-30 |
Modernatx Inc |
POLYNUCLEOTIDES CODING FOR PHENYLALANINE HYDROXYLASE FOR THE TREATMENT OF PHENYLKETONURIS
|
EP3723796A1
(en)
|
2017-12-13 |
2020-10-21 |
CureVac AG |
Flavivirus vaccine
|
CA3086343A1
(en)
|
2017-12-18 |
2019-06-27 |
Alnylam Pharmaceuticals, Inc. |
High mobility group box-1 (hmgb1) irna compositions and methods of use thereof
|
CA3084061A1
(en)
|
2017-12-20 |
2019-06-27 |
Translate Bio, Inc. |
Improved composition and methods for treatment of ornithine transcarbamylase deficiency
|
EP3733647B1
(en)
|
2017-12-27 |
2022-06-15 |
Eisai R&D Management Co., Ltd. |
Cationic lipid
|
US11802146B2
(en)
|
2018-01-05 |
2023-10-31 |
Modernatx, Inc. |
Polynucleotides encoding anti-chikungunya virus antibodies
|
TW201934129A
(en)
|
2018-01-15 |
2019-09-01 |
美商Ionis製藥公司 |
Modulators of DNM2 expression
|
CA3089117A1
(en)
|
2018-01-30 |
2019-08-08 |
Modernatx, Inc. |
Compositions and methods for delivery of agents to immune cells
|
AU2019218987A1
(en)
|
2018-02-12 |
2020-07-23 |
Ionis Pharmaceuticals, Inc. |
Modified compounds and uses thereof
|
WO2019193183A2
(en)
|
2018-04-05 |
2019-10-10 |
Curevac Ag |
Novel yellow fever nucleic acid molecules for vaccination
|
US20210052506A1
(en)
*
|
2018-04-09 |
2021-02-25 |
Orgenesis Inc. |
Bioxomes particles, redoxomes, method and composition
|
US20210163928A1
(en)
|
2018-04-11 |
2021-06-03 |
Modernatx, Inc. |
Messenger rna comprising functional rna elements
|
EP3775211B1
(en)
|
2018-04-12 |
2023-04-05 |
MiNA Therapeutics Limited |
Sirt1-sarna compositions and methods of use
|
SG11202008225PA
(en)
|
2018-04-17 |
2020-11-27 |
Curevac Ag |
Novel rsv rna molecules and compositions for vaccination
|
SG11202010012PA
(en)
|
2018-05-09 |
2020-11-27 |
Ionis Pharmaceuticals Inc |
Compounds and methods for reducing fxi expression
|
US11904081B2
(en)
|
2018-05-11 |
2024-02-20 |
Lupagen, Inc. |
Systems and methods for closed loop, real-time modifications of patient cells
|
TW202016304A
(en)
|
2018-05-14 |
2020-05-01 |
美商阿尼拉製藥公司 |
Angiotensinogen (agt) irna compositions and methods of use thereof
|
US20210346306A1
(en)
|
2018-05-23 |
2021-11-11 |
Modernatx, Inc. |
Delivery of dna
|
CN112437767B
(en)
|
2018-05-24 |
2023-10-27 |
川斯勒佰尔公司 |
thioester cationic lipids
|
EP3802507A1
(en)
|
2018-05-30 |
2021-04-14 |
Translate Bio, Inc. |
Vitamin cationic lipids
|
MA52762A
(en)
|
2018-05-30 |
2021-04-14 |
Translate Bio Inc |
CATIONIC FAT CONTAINING A STEROID FRACTION
|
CA3101484A1
(en)
|
2018-05-30 |
2019-12-05 |
Translate Bio, Inc. |
Phosphoester cationic lipids
|
AU2019277361A1
(en)
|
2018-05-30 |
2020-12-17 |
Translate Bio, Inc. |
Messenger RNA vaccines and uses thereof
|
JP7178409B2
(en)
|
2018-06-08 |
2022-11-25 |
富士フイルム株式会社 |
Compound or its salt and lipid particles
|
US20210260178A1
(en)
|
2018-06-27 |
2021-08-26 |
Curevac Ag |
Novel lassa virus rna molecules and compositions for vaccination
|
EP3813798A1
(en)
|
2018-06-28 |
2021-05-05 |
AstraZeneca AB |
Exosome extracellular vesicles and methods of use
|
US20210378977A1
(en)
|
2018-07-23 |
2021-12-09 |
Translate Bio, Inc. |
Dry Powder Formulations for Messenger RNA
|
US20220184185A1
(en)
|
2018-07-25 |
2022-06-16 |
Modernatx, Inc. |
Mrna based enzyme replacement therapy combined with a pharmacological chaperone for the treatment of lysosomal storage disorders
|
US20210292768A1
(en)
|
2018-08-08 |
2021-09-23 |
Arcturus Therapeutics, Inc. |
Compositions and agents against nonalcoholic steatohepatitis
|
JP2021534101A
(en)
|
2018-08-09 |
2021-12-09 |
ヴェルソー セラピューティクス, インコーポレイテッド |
Oligonucleotide compositions for targeting CCR2 and CSF1R and their use
|
US20210170005A1
(en)
|
2018-08-15 |
2021-06-10 |
University Of Florida Research Foundation, Inc. |
Methods of sensitizing tumors to treatment with immune checkpoint inhibitors
|
EP3841208A1
(en)
|
2018-08-24 |
2021-06-30 |
Translate Bio, Inc. |
Methods for purification of messenger rna
|
US11357726B2
(en)
|
2018-08-29 |
2022-06-14 |
Translate Bio, Inc. |
Process of preparing mRNA-loaded lipid nanoparticles
|
US20220110966A1
(en)
|
2018-09-02 |
2022-04-14 |
Modernatx, Inc. |
Polynucleotides encoding very long-chain acyl-coa dehydrogenase for the treatment of very long-chain acyl-coa dehydrogenase deficiency
|
US20220054610A1
(en)
|
2018-09-12 |
2022-02-24 |
University Of Florida Research Foundation, Inc. |
Slow-cycling cell-rna based nanoparticle vaccine to treat cancer
|
MA53608A
(en)
|
2018-09-13 |
2021-07-21 |
Modernatx Inc |
POLYNUCLEOTIDES ENCODED FOR THE E1-ALPHA, E1-BETA AND E2 SUBUNITS OF THE BRANCHED-CHAIN ALPHA-KETOACID DEHYDROGENASE COMPLEX FOR THE TREATMENT OF LEUCINOSIS
|
MA53609A
(en)
|
2018-09-13 |
2021-07-21 |
Modernatx Inc |
POLYNUCLEOTIDES ENCODED GLUCOSE-6-PHOSPHATASE FOR THE TREATMENT OF GLYCOGENOSIS
|
CA3112398A1
(en)
|
2018-09-14 |
2020-03-19 |
Modernatx, Inc. |
Polynucleotides encoding uridine diphosphate glycosyltransferase 1 family, polypeptide a1 for the treatment of crigler-najjar syndrome
|
EP3849617A1
(en)
|
2018-09-14 |
2021-07-21 |
Translate Bio, Inc. |
Composition and methods for treatment of methylmalonic acidemia
|
EP3849589A1
(en)
|
2018-09-14 |
2021-07-21 |
ModernaTX, Inc. |
Methods and compositions for treating cancer using mrna therapeutics
|
AU2019344776A1
(en)
|
2018-09-18 |
2021-01-21 |
Alnylam Pharmaceuticals, Inc. |
Ketohexokinase (KHK) iRNA compositions and methods of use thereof
|
TW202023573A
(en)
|
2018-09-19 |
2020-07-01 |
美商Ionis製藥公司 |
Modulators of pnpla3 expression
|
CN113271926A
(en)
|
2018-09-20 |
2021-08-17 |
摩登纳特斯有限公司 |
Preparation of lipid nanoparticles and methods of administration thereof
|
WO2020069169A1
(en)
|
2018-09-27 |
2020-04-02 |
Modernatx, Inc. |
Polynucleotides encoding arginase 1 for the treatment of arginase deficiency
|
CN113164379B
(en)
*
|
2018-10-01 |
2024-04-16 |
阿尔尼拉姆医药品有限公司 |
Biodegradable lipids for delivery of active agents
|
CN113166783A
(en)
|
2018-10-09 |
2021-07-23 |
不列颠哥伦比亚大学 |
Compositions and systems comprising transfection-active vesicles free of organic solvents and detergents and methods related thereto
|
KR20210090634A
(en)
|
2018-10-19 |
2021-07-20 |
트랜슬레이트 바이오 인코포레이티드 |
Pump-free encapsulation of messenger RNA
|
US10913951B2
(en)
|
2018-10-31 |
2021-02-09 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Silencing of HNF4A-P2 isoforms with siRNA to improve hepatocyte function in liver failure
|
US20220001026A1
(en)
|
2018-11-08 |
2022-01-06 |
Modernatx, Inc. |
Use of mrna encoding ox40l to treat cancer in human patients
|
EP3877368A1
(en)
|
2018-11-09 |
2021-09-15 |
Translate Bio, Inc. |
2,5-dioxopiperazine lipids with intercalated ester, thioester, disulfide and anhydride moieities
|
US20220071905A1
(en)
|
2018-11-09 |
2022-03-10 |
Translate Bio, Inc. |
Peg lipidoid compounds
|
WO2020097511A2
(en)
|
2018-11-09 |
2020-05-14 |
Translate Bio, Inc. |
Messenger rna therapy for treatment of ocular diseases
|
AU2019377525A1
(en)
|
2018-11-09 |
2021-05-27 |
Translate Bio, Inc. |
Multi-PEG lipid compounds
|
CA3119449A1
(en)
|
2018-11-12 |
2020-05-22 |
Translate Bio, Inc. |
Methods for inducing immune tolerance
|
US20230050672A1
(en)
|
2018-11-21 |
2023-02-16 |
Translate Bio, Inc. |
Cationic lipid compounds
|
JP2022513657A
(en)
|
2018-11-28 |
2022-02-09 |
クリスパー セラピューティクス アクチェンゲゼルシャフト |
A CAS9-encoding mRNA optimized for use in LNP
|
ES2960692T3
(en)
|
2018-12-06 |
2024-03-06 |
Arcturus Therapeutics Inc |
Compositions and methods for the treatment of ornithine transcarbamylase deficiency
|
TW202039534A
(en)
|
2018-12-14 |
2020-11-01 |
美商美國禮來大藥廠 |
Kras variant mrna molecules
|
US20220056455A1
(en)
|
2018-12-20 |
2022-02-24 |
Praxis Precision Medicines, Inc. |
Compositions and methods for the treatment of kcnt1 related disorders
|
AU2019410737A1
(en)
|
2018-12-21 |
2021-06-10 |
CureVac SE |
RNA for malaria vaccines
|
US11559561B2
(en)
|
2019-01-07 |
2023-01-24 |
Translate Bio, Inc. |
Composition and methods for treatment of primary ciliary dyskinesia
|
SG11202106987WA
(en)
|
2019-01-11 |
2021-07-29 |
Acuitas Therapeutics Inc |
Lipids for lipid nanoparticle delivery of active agents
|
SG11202108100PA
(en)
|
2019-01-31 |
2021-08-30 |
Modernatx Inc |
Methods of preparing lipid nanoparticles
|
US20220126244A1
(en)
|
2019-01-31 |
2022-04-28 |
Modernatx, Inc. |
Vortex mixers and associated methods, systems, and apparatuses thereof
|
EP3920950A1
(en)
|
2019-02-08 |
2021-12-15 |
CureVac AG |
Coding rna administered into the suprachoroidal space in the treatment of ophtalmic diseases
|
CN113924365A
(en)
|
2019-03-29 |
2022-01-11 |
迪克纳制药公司 |
Compositions and methods for treating KRAS-related diseases or disorders
|
EP3947646A1
(en)
|
2019-04-05 |
2022-02-09 |
Precision BioSciences, Inc. |
Methods of preparing populations of genetically-modified immune cells
|
US20220211740A1
(en)
|
2019-04-12 |
2022-07-07 |
Mina Therapeutics Limited |
Sirt1-sarna compositions and methods of use
|
EP3956303A1
(en)
|
2019-04-18 |
2022-02-23 |
Translate Bio, Inc. |
Cystine cationic lipids
|
US20220233444A1
(en)
|
2019-04-22 |
2022-07-28 |
Translate Bio, Inc. |
Thioester cationic lipids
|
US20220218808A1
(en)
|
2019-05-02 |
2022-07-14 |
University Of Florida Research Foundation, Inc. |
Compositions for treatment of diffuse intrinsic pontine glioma
|
US20220177880A1
(en)
|
2019-05-03 |
2022-06-09 |
Dicerna Pharmaceuticals, Inc. |
Double-stranded nucleic acid inhibitor molecules with shortened sense strands
|
WO2020227085A1
(en)
|
2019-05-03 |
2020-11-12 |
Translate Bio, Inc. |
Di-thioester cationic lipids
|
WO2020227510A1
(en)
|
2019-05-07 |
2020-11-12 |
Modernatx, Inc. |
Polynucleotides for disrupting immune cell activity and methods of use thereof
|
MA55887A
(en)
|
2019-05-07 |
2022-03-16 |
Modernatx Inc |
DIFFERENTIALLY EXPRESSED IMMUNE CELL MICROARN FOR REGULATION OF PROTEIN EXPRESSION
|
WO2020227615A1
(en)
|
2019-05-08 |
2020-11-12 |
Modernatx, Inc. |
Polynucleotides encoding methylmalonyl-coa mutase for the treatment of methylmalonic acidemia
|
EP3965797A1
(en)
|
2019-05-08 |
2022-03-16 |
AstraZeneca AB |
Compositions for skin and wounds and methods of use thereof
|
SG11202112922WA
(en)
|
2019-05-22 |
2021-12-30 |
Massachusetts Inst Technology |
Circular rna compositions and methods
|
WO2020243540A1
(en)
|
2019-05-31 |
2020-12-03 |
Translate Bio, Inc. |
Macrocyclic lipids
|
CA3142608A1
(en)
|
2019-06-04 |
2020-12-10 |
Cocoon Biotech Inc. |
Silk-based products, formulations, and methods of use
|
JP7241869B2
(en)
*
|
2019-06-07 |
2023-03-17 |
富士フイルム株式会社 |
Lipid composition
|
EP3986452A1
(en)
|
2019-06-18 |
2022-04-27 |
CureVac AG |
Rotavirus mrna vaccine
|
WO2020257611A1
(en)
|
2019-06-21 |
2020-12-24 |
Translate Bio, Inc. |
Cationic lipids comprising an hydroxy moiety
|
US20230092238A1
(en)
|
2019-06-21 |
2023-03-23 |
Translate Bio, Inc. |
Tricine and Citric Acid Lipids
|
MA56517A
(en)
|
2019-06-24 |
2022-04-27 |
Modernatx Inc |
MESSENGER RNA COMPRISING FUNCTIONAL RNA ELEMENTS AND THEIR USES
|
WO2020263883A1
(en)
|
2019-06-24 |
2020-12-30 |
Modernatx, Inc. |
Endonuclease-resistant messenger rna and uses thereof
|
JP2022541740A
(en)
|
2019-07-08 |
2022-09-27 |
トランスレイト バイオ, インコーポレイテッド |
Improved mRNA-loaded lipid nanoparticles and processes for making them
|
EP3999097A1
(en)
|
2019-07-18 |
2022-05-25 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
Methods for inducing full ablation of hematopoiesis
|
EP3999642A1
(en)
|
2019-07-19 |
2022-05-25 |
Flagship Pioneering Innovations VI, LLC |
Recombinase compositions and methods of use
|
WO2021016430A1
(en)
|
2019-07-23 |
2021-01-28 |
Translate Bio, Inc. |
Stable compositions of mrna-loaded lipid nanoparticles and processes of making
|
EP4003296A1
(en)
|
2019-07-31 |
2022-06-01 |
ModernaTX, Inc. |
Compositions and methods for delivery of rna interference agents to immune cells
|
EP4007812A1
(en)
|
2019-08-01 |
2022-06-08 |
Alnylam Pharmaceuticals, Inc. |
Serpin family f member 2 (serpinf2) irna compositions and methods of use thereof
|
EP4007811A2
(en)
|
2019-08-01 |
2022-06-08 |
Alnylam Pharmaceuticals, Inc. |
Carboxypeptidase b2 (cpb2) irna compositions and methods of use thereof
|
JP2022543467A
(en)
|
2019-08-07 |
2022-10-12 |
モデルナティエックス インコーポレイテッド |
Compositions and methods for enhanced drug delivery
|
WO2021030522A1
(en)
|
2019-08-13 |
2021-02-18 |
Alnylam Pharmaceuticals, Inc. |
SMALL RIBOSOMAL PROTEIN SUBUNIT 25 (RPS25) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
|
US20220296628A1
(en)
|
2019-08-14 |
2022-09-22 |
Curevac Ag |
Rna combinations and compositions with decreased immunostimulatory properties
|
CA3150458A1
(en)
|
2019-08-14 |
2021-02-18 |
Acuitas Therapeutics, Inc. |
Improved lipid nanoparticles for delivery of nucleic acids
|
WO2021034639A1
(en)
|
2019-08-16 |
2021-02-25 |
Regeneron Pharmaceuticals, Inc. |
High concentration anti-c5 formulations
|
CN114929205A
(en)
|
2019-09-06 |
2022-08-19 |
世代生物公司 |
Lipid nanoparticle compositions comprising terminally-blocked DNA and cleavable lipids and methods of use thereof
|
WO2021055833A1
(en)
|
2019-09-19 |
2021-03-25 |
Modernatx, Inc. |
Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents
|
CA3148158A1
(en)
*
|
2019-09-20 |
2021-03-25 |
Longcheng Li |
Nucleic acid molecule for treating thrombocytopenia and use thereof
|
WO2021055609A1
(en)
|
2019-09-20 |
2021-03-25 |
Translate Bio, Inc. |
Mrna encoding engineered cftr
|
JP2022548399A
(en)
|
2019-09-23 |
2022-11-18 |
オメガ セラピューティクス, インコーポレイテッド |
Compositions and methods for modulating hepatocyte nuclear factor 4-alpha (HNF4α) gene expression
|
JP2022548320A
(en)
|
2019-09-23 |
2022-11-17 |
オメガ セラピューティクス, インコーポレイテッド |
Compositions and methods for modulating apolipoprotein B (APOB) gene expression
|
JP2022552249A
(en)
|
2019-10-14 |
2022-12-15 |
アストラゼネカ・アクチエボラーグ |
Modulators of PNPLA3 expression
|
JP2022552378A
(en)
|
2019-10-15 |
2022-12-15 |
モデルナティエックス インコーポレイテッド |
mRNA encoding granulocyte-macrophage colony-stimulating factor for treating Parkinson's disease
|
WO2021076828A1
(en)
|
2019-10-18 |
2021-04-22 |
Alnylam Pharmaceuticals, Inc. |
Solute carrier family member irna compositions and methods of use thereof
|
CN115279418A
(en)
|
2019-10-21 |
2022-11-01 |
川斯勒佰尔公司 |
Compositions, methods and uses of messenger RNA
|
EP4048793A1
(en)
|
2019-10-22 |
2022-08-31 |
Alnylam Pharmaceuticals, Inc. |
Complement component c3 irna compositions and methods of use thereof
|
CN111205994B
(en)
*
|
2019-10-23 |
2021-09-21 |
上海市第十人民医院 |
Fusobacterium nucleatum subspecies animal strain and application thereof
|
CN110903998B
(en)
*
|
2019-10-23 |
2021-09-21 |
上海市第十人民医院 |
Intestinal tract separated fusobacterium nucleatum Wenzeri strain and application thereof
|
CN111004738B
(en)
*
|
2019-10-23 |
2021-09-21 |
上海市第十人民医院 |
Fusobacterium nucleatum subspecies pleomorphus isolate and application thereof
|
JP2022553377A
(en)
|
2019-10-25 |
2022-12-22 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
Dosing Regimens for Treatment or Prevention of C5-Related Diseases
|
CA3155921A1
(en)
|
2019-11-01 |
2021-05-06 |
Alnylam Pharmaceuticals, Inc. |
Huntingtin (htt) irna agent compositions and methods of use thereof
|
KR20220115946A
(en)
|
2019-11-13 |
2022-08-19 |
알닐람 파마슈티칼스 인코포레이티드 |
Methods and compositions for treating angiotensinogen (AGT) related disorders
|
CN117417265A
(en)
|
2019-11-15 |
2024-01-19 |
富士胶片株式会社 |
Lipid composition
|
WO2021102373A1
(en)
|
2019-11-22 |
2021-05-27 |
Alnylam Pharmaceuticals, Inc. |
Ataxin3 (atxn3) rnai agent compositions and methods of use thereof
|
JPWO2021117769A1
(en)
*
|
2019-12-10 |
2021-06-17 |
|
|
WO2021117770A1
(en)
*
|
2019-12-10 |
2021-06-17 |
富士フイルム株式会社 |
Pharmaceutical composition and treatment agent
|
CN115151641A
(en)
|
2019-12-13 |
2022-10-04 |
阿尔尼拉姆医药品有限公司 |
Human chromosome 9 open reading frame 72 (C9 ORF 72) iRNA agent compositions and methods of use thereof
|
WO2021126734A1
(en)
|
2019-12-16 |
2021-06-24 |
Alnylam Pharmaceuticals, Inc. |
Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
|
IL293890A
(en)
|
2019-12-20 |
2022-08-01 |
Curevac Ag |
Lipid nanoparticles for delivery of nucleic acids
|
JP2023508882A
(en)
|
2019-12-20 |
2023-03-06 |
トランスレイト バイオ, インコーポレイテッド |
Rectal delivery of messenger RNA
|
CN115461042A
(en)
|
2019-12-20 |
2022-12-09 |
翻译生物公司 |
Improved method for preparing MRNA-loaded lipid nanoparticles
|
CN110974954B
(en)
*
|
2019-12-24 |
2021-03-16 |
珠海丽凡达生物技术有限公司 |
Lipid nanoparticle for enhancing immune effect of nucleic acid vaccine and preparation method thereof
|
WO2021142245A1
(en)
|
2020-01-10 |
2021-07-15 |
Translate Bio, Inc. |
Compounds, pharmaceutical compositions and methods for modulating expression of muc5b in lung cells and tissues
|
US20230112857A1
(en)
|
2020-01-10 |
2023-04-13 |
Modernatx, Inc. |
Methods of making tolerogenic dendritic cells
|
WO2021146488A1
(en)
|
2020-01-15 |
2021-07-22 |
Dicerna Pharmaceuticals, Inc. |
4'-o-methylene phosphonate nucleic acids and analogues thereof
|
CN116133652A
(en)
|
2020-01-31 |
2023-05-16 |
摩登纳特斯有限公司 |
Method for preparing lipid nanoparticles
|
WO2021154941A1
(en)
|
2020-01-31 |
2021-08-05 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions for use in the treatment of amyotrophic lateral sclerosis (als)
|
MX2022009460A
(en)
|
2020-02-04 |
2022-12-16 |
Curevac Ag |
Coronavirus vaccine.
|
BR112022015770A2
(en)
|
2020-02-10 |
2022-10-11 |
Alnylam Pharmaceuticals Inc |
COMPOSITIONS AND METHODS TO SILENCE VEGF-A EXPRESSION
|
IL295496A
(en)
|
2020-02-18 |
2022-10-01 |
Alnylam Pharmaceuticals Inc |
Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof
|
US20210275689A1
(en)
|
2020-02-25 |
2021-09-09 |
Translate Bio, Inc. |
Processes of preparing mrna-loaded lipid nanoparticles
|
US20220064638A1
(en)
|
2020-02-28 |
2022-03-03 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating smn2
|
CA3174708A1
(en)
*
|
2020-03-04 |
2021-09-10 |
Verve Therapeutics, Inc. |
Compositions and methods for targeted rna delivery
|
EP4114947A1
(en)
|
2020-03-05 |
2023-01-11 |
Alnylam Pharmaceuticals, Inc. |
Complement component c3 irna compositions and methods of use thereof for treating or preventing complement component c3-associated diseases
|
JP2023516095A
(en)
|
2020-03-06 |
2023-04-17 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
Ketohexokinase (KHK) iRNA compositions and methods of use thereof
|
CA3171219A1
(en)
|
2020-03-09 |
2021-09-16 |
Arcturus Therapeutics, Inc. |
Compositions and methods for inducing immune responses
|
CA3173528A1
(en)
|
2020-03-11 |
2021-09-16 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating forkhead box p3 (foxp3) gene expression
|
CA3172572A1
(en)
|
2020-03-24 |
2021-09-30 |
Generation Bio Co. |
Non-viral dna vectors and uses thereof for expressing factor ix therapeutics
|
WO2021195218A1
(en)
|
2020-03-24 |
2021-09-30 |
Generation Bio Co. |
Non-viral dna vectors and uses thereof for expressing gaucher therapeutics
|
TW202204615A
(en)
|
2020-03-26 |
2022-02-01 |
美商阿尼拉製藥公司 |
Coronavirus irna compositions and methods of use thereof
|
US20230226169A1
(en)
|
2020-04-01 |
2023-07-20 |
University Of Florida Research Foundation Incorporated |
Multilamellar rna nanoparticle vaccine against sars-cov-2
|
TW202204618A
(en)
|
2020-04-06 |
2022-02-01 |
美商艾爾妮蘭製藥公司 |
Compositions and methods for silencing myoc expression
|
CA3179678A1
(en)
|
2020-04-07 |
2021-10-14 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing scn9a expression
|
EP4133077A1
(en)
|
2020-04-07 |
2023-02-15 |
Alnylam Pharmaceuticals, Inc. |
Transmembrane serine protease 2 (tmprss2) irna compositions and methods of use thereof
|
WO2021206917A1
(en)
|
2020-04-07 |
2021-10-14 |
Alnylam Pharmaceuticals, Inc. |
ANGIOTENSIN-CONVERTING ENZYME 2 (ACE2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
WO2021222065A1
(en)
|
2020-04-27 |
2021-11-04 |
Alnylam Pharmaceuticals, Inc. |
Apolipoprotein e (apoe) irna agent compositions and methods of use thereof
|
JP2023523790A
(en)
|
2020-04-30 |
2023-06-07 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
COMPLEMENT FACTOR B (CFB) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
US20230190954A1
(en)
|
2020-05-07 |
2023-06-22 |
Translate Bio, Inc. |
Composition and methods for treatment of primary ciliary dyskinesia
|
CA3177940A1
(en)
|
2020-05-07 |
2021-11-11 |
Anusha DIAS |
Optimized nucleotide sequences encoding sars-cov-2 antigens
|
US20230181619A1
(en)
|
2020-05-07 |
2023-06-15 |
Translate Bio, Inc. |
Improved compositions for cftr mrna therapy
|
US20230173104A1
(en)
|
2020-05-14 |
2023-06-08 |
Modernatx, Inc. |
Lnp compositions comprising an mrna therapeutic and an effector molecule
|
US20230226219A1
(en)
|
2020-05-14 |
2023-07-20 |
Translate Bio, Inc. |
Peg lipidoid compounds
|
EP4150086A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of leucine rich repeat kinase 2 (lrrk2)
|
EP4150076A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of methyl-cpg binding protein 2 (mecp2)
|
WO2021231698A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of argininosuccinate lyase (asl)
|
EP4150088A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of argininosuccinate synthetase (ass1)
|
WO2021231691A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of retinoschisin 1 (rsi)
|
WO2021231685A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of transmembrane channel-like protein 1 (tmc1)
|
WO2021231679A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of gap junction protein beta 2 (gjb2)
|
AU2021273502A1
(en)
|
2020-05-15 |
2023-02-02 |
Translate Bio, Inc. |
Lipid nanoparticle formulations for mRNA delivery
|
EP4150090A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of otoferlin (otof)
|
IL298282A
(en)
|
2020-05-18 |
2023-01-01 |
Max Biology Co Ltd |
Lipid-polymer compositions and methods of use
|
CA3179420A1
(en)
|
2020-05-20 |
2021-11-25 |
Avak Kahvejian |
Coronavirus antigen compositions and their uses
|
WO2021236930A1
(en)
|
2020-05-20 |
2021-11-25 |
Flagship Pioneering Innovations Vi, Llc |
Immunogenic compositions and uses thereof
|
WO2021243207A1
(en)
|
2020-05-28 |
2021-12-02 |
Modernatx, Inc. |
Use of mrnas encoding ox40l, il-23 and il-36gamma for treating cancer
|
CN116018405A
(en)
|
2020-05-29 |
2023-04-25 |
旗舰先锋创新Vi有限责任公司 |
TREM compositions and related methods
|
IL298084A
(en)
|
2020-05-29 |
2023-01-01 |
CureVac SE |
Nucleic acid based combination vaccines
|
WO2021243301A2
(en)
|
2020-05-29 |
2021-12-02 |
Flagship Pioneering Innovations Vi, Llc. |
Trem compositions and methods relating thereto
|
US20230233475A1
(en)
|
2020-06-01 |
2023-07-27 |
Modernatx, Inc. |
Lipid nanoparticles containing polynucleotides encoding glucose-6-phosphatase and uses thereof
|
AU2021285812A1
(en)
|
2020-06-01 |
2023-01-05 |
Modernatx, Inc. |
Phenylalanine hydroxylase variants and uses thereof
|
US11408000B2
(en)
|
2020-06-03 |
2022-08-09 |
Triplet Therapeutics, Inc. |
Oligonucleotides for the treatment of nucleotide repeat expansion disorders associated with MSH3 activity
|
EP4162050A1
(en)
|
2020-06-09 |
2023-04-12 |
Alnylam Pharmaceuticals, Inc. |
Rnai compositions and methods of use thereof for delivery by inhalation
|
JP2023530461A
(en)
|
2020-06-18 |
2023-07-18 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
Xanthine dehydrogenase (XDH) iRNA compositions and methods of use thereof
|
JP2023531511A
(en)
|
2020-06-23 |
2023-07-24 |
モダーナティエックス・インコーポレイテッド |
LNP compositions comprising mRNA therapeutics with extended half-lives
|
WO2022006527A1
(en)
|
2020-07-02 |
2022-01-06 |
Maritime Therapeutics, Inc. |
Compositions and methods for reverse gene therapy
|
BR112022027038A2
(en)
|
2020-07-08 |
2023-01-24 |
Janssen Sciences Ireland Unlimited Co |
RNA REPLICON VACCINES AGAINST HBV
|
WO2022011262A1
(en)
|
2020-07-10 |
2022-01-13 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Methods and compositions for treating epilepsy
|
EP4182332A1
(en)
|
2020-07-17 |
2023-05-24 |
Greenlight Biosciences, Inc. |
Nucleic acid therapeutics for genetic disorders
|
EP4189098A1
(en)
|
2020-07-27 |
2023-06-07 |
Anjarium Biosciences AG |
Compositions of dna molecules, methods of making therefor, and methods of use thereof
|
WO2022023559A1
(en)
|
2020-07-31 |
2022-02-03 |
Curevac Ag |
Nucleic acid encoded antibody mixtures
|
EP4192505A1
(en)
|
2020-08-04 |
2023-06-14 |
Dicerna Pharmaceuticals, Inc. |
Systemic delivery of oligonucleotides
|
BR112023002071A2
(en)
|
2020-08-06 |
2023-05-02 |
Modernatx Inc |
METHODS TO PREPARE LIPID NANOPARTICLES
|
WO2022043551A2
(en)
|
2020-08-31 |
2022-03-03 |
Curevac Ag |
Multivalent nucleic acid based coronavirus vaccines
|
JP2023542492A
(en)
|
2020-09-03 |
2023-10-10 |
フラッグシップ パイオニアリング イノベーションズ シックス,エルエルシー |
Immunogenic compositions and uses thereof
|
EP4212162A4
(en)
|
2020-09-14 |
2024-02-28 |
Fujifilm Corp |
Lipid composition
|
BR112023005269A2
(en)
|
2020-09-23 |
2023-04-25 |
Translate Bio Inc |
TES-BASED CATION LIPIDS
|
AU2021349262A1
(en)
|
2020-09-23 |
2023-06-08 |
Translate Bio, Inc. |
Piperazine-based cationic lipids
|
EP4217489A1
(en)
|
2020-09-24 |
2023-08-02 |
Alnylam Pharmaceuticals, Inc. |
Dipeptidyl peptidase 4 (dpp4) irna compositions and methods of use thereof
|
WO2022067091A1
(en)
*
|
2020-09-25 |
2022-03-31 |
DNARx |
Systems and methods for expressing biomolecules in a subject
|
WO2022076291A1
(en)
|
2020-10-05 |
2022-04-14 |
Alnylam Pharmaceuticals, Inc. |
G protein-coupled receptor 75 (gpr75) irna compositions and methods of use thereof
|
WO2022074541A1
(en)
|
2020-10-05 |
2022-04-14 |
Max Biology Co. Ltd. |
Cannabinoid-containing compositions and use for treating and preventing diseases
|
US20230372440A1
(en)
|
2020-10-06 |
2023-11-23 |
Translate Bio, Inc. |
Improved process and formulation of lipid nanoparticles
|
US20230365995A1
(en)
|
2020-10-07 |
2023-11-16 |
Precision Biosciences, Inc. |
Lipid nanoparticle compositions
|
JP2023545128A
(en)
|
2020-10-12 |
2023-10-26 |
トランスレイト バイオ, インコーポレイテッド |
Improved method for producing mRNA-loaded lipid nanoparticles
|
US20220133631A1
(en)
|
2020-10-12 |
2022-05-05 |
Translate Bio, Inc. |
Process of preparing ice-based lipid nanoparticles
|
AU2021365822A1
(en)
|
2020-10-21 |
2023-06-08 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating primary hyperoxaluria
|
EP4232582A1
(en)
|
2020-10-23 |
2023-08-30 |
Alnylam Pharmaceuticals, Inc. |
Mucin 5b (muc5b) irna compositions and methods of use thereof
|
JP2023548587A
(en)
|
2020-11-09 |
2023-11-17 |
トランスレイト バイオ, インコーポレイテッド |
Improved compositions for codon-optimized mRNA delivery
|
EP4243776A1
(en)
|
2020-11-13 |
2023-09-20 |
Modernatx, Inc. |
Polynucleotides encoding cystic fibrosis transmembrane conductance regulator for the treatment of cystic fibrosis
|
IL302709A
(en)
|
2020-11-13 |
2023-07-01 |
Alnylam Pharmaceuticals Inc |
COAGULATION FACTOR V (F5) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
US11447521B2
(en)
|
2020-11-18 |
2022-09-20 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating angiotensinogen expression
|
JP2023550644A
(en)
|
2020-11-25 |
2023-12-04 |
トランスレイト バイオ, インコーポレイテッド |
Stable liquid lipid nanoparticle formulation
|
WO2022112855A1
(en)
|
2020-11-27 |
2022-06-02 |
Guangzhou Ribobio Co., Ltd |
Lipid compound and the composition thereof
|
EP4025556A4
(en)
|
2020-11-27 |
2023-08-09 |
Guangzhou Ribobio Co., Ltd |
Lipid compound and the composition thereof
|
US20230015616A1
(en)
|
2020-11-30 |
2023-01-19 |
Argorna Pharmaceuticals Ltd |
Coronavirus vaccines and uses thereof
|
WO2022119873A1
(en)
|
2020-12-01 |
2022-06-09 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for inhibition of hao1 (hydroxyacid oxidase 1 (glycolate oxidase)) gene expression
|
EP4259795A1
(en)
|
2020-12-08 |
2023-10-18 |
Alnylam Pharmaceuticals, Inc. |
Coagulation factor x (f10) irna compositions and methods of use thereof
|
GB2603454A
(en)
|
2020-12-09 |
2022-08-10 |
Ucl Business Ltd |
Novel therapeutics for the treatment of neurodegenerative disorders
|
CA3171051A1
(en)
|
2020-12-22 |
2022-06-30 |
Curevac Ag |
Pharmaceutical composition comprising lipid-based carriers encapsulating rna for multidose administration
|
WO2022137133A1
(en)
|
2020-12-22 |
2022-06-30 |
Curevac Ag |
Rna vaccine against sars-cov-2 variants
|
EP4267732A1
(en)
|
2020-12-23 |
2023-11-01 |
Flagship Pioneering Innovations VI, LLC |
Compositions of modified trems and uses thereof
|
CA3203442A1
(en)
|
2020-12-28 |
2022-07-07 |
Arcturus Therapeutics, Inc. |
Transcription activator-like effector nucleases (talens) targeting hbv
|
WO2022150260A1
(en)
|
2021-01-05 |
2022-07-14 |
Alnylam Pharmaceuticals, Inc. |
COMPLEMENT COMPONENT 9 (C9) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
EP4277929A1
(en)
|
2021-01-14 |
2023-11-22 |
Translate Bio, Inc. |
Methods and compositions for delivering mrna coded antibodies
|
WO2022162027A2
(en)
|
2021-01-27 |
2022-08-04 |
Curevac Ag |
Method of reducing the immunostimulatory properties of in vitro transcribed rna
|
EP4289814A1
(en)
|
2021-02-04 |
2023-12-13 |
Shionogi & Co., Ltd |
Cationic lipid
|
CN117157101A
(en)
|
2021-02-08 |
2023-12-01 |
德克萨斯大学系统董事会 |
Unsaturated dendrimer compositions, related formulations, and methods of use thereof
|
WO2022174079A1
(en)
|
2021-02-12 |
2022-08-18 |
Modernatx, Inc. |
Lnp compositions comprising payloads for in vivo therapy
|
TW202305131A
(en)
|
2021-02-12 |
2023-02-01 |
美商艾拉倫製藥股份有限公司 |
SUPEROXIDE DISMUTASE 1 (SOD1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING SUPEROXIDE DISMUTASE 1- (SOD1-) ASSOCIATED NEURODEGENERATIVE DISEASES
|
US11524023B2
(en)
|
2021-02-19 |
2022-12-13 |
Modernatx, Inc. |
Lipid nanoparticle compositions and methods of formulating the same
|
JP2024509783A
(en)
|
2021-02-25 |
2024-03-05 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
Prion protein (PRNP) IRNA compositions and methods of use thereof
|
KR20230152014A
(en)
|
2021-02-26 |
2023-11-02 |
에트리스 게엠베하 |
Formulations for aerosol formation and aerosols for nucleic acid delivery
|
BR112023016645A2
(en)
|
2021-02-26 |
2023-11-14 |
Alnylam Pharmaceuticals Inc |
KETOHEXOKINASE (KHK) IRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
TW202302849A
(en)
|
2021-03-04 |
2023-01-16 |
美商艾拉倫製藥股份有限公司 |
Angiopoietin-like 3 (angptl3) irna compositions and methods of use thereof
|
EP4305169A1
(en)
|
2021-03-12 |
2024-01-17 |
Alnylam Pharmaceuticals, Inc. |
Glycogen synthase kinase 3 alpha (gsk3a) irna compositions and methods of use thereof
|
EP4314260A1
(en)
|
2021-03-24 |
2024-02-07 |
Modernatx, Inc. |
Lipid nanoparticles and polynucleotides encoding ornithine transcarbamylase for the treatment of ornithine transcarbamylase deficiency
|
WO2022204371A1
(en)
|
2021-03-24 |
2022-09-29 |
Modernatx, Inc. |
Lipid nanoparticles containing polynucleotides encoding glucose-6-phosphatase and uses thereof
|
WO2022204369A1
(en)
|
2021-03-24 |
2022-09-29 |
Modernatx, Inc. |
Polynucleotides encoding methylmalonyl-coa mutase for the treatment of methylmalonic acidemia
|
WO2022204390A1
(en)
|
2021-03-24 |
2022-09-29 |
Modernatx, Inc. |
Lipid nanoparticles containing polynucleotides encoding phenylalanine hydroxylase and uses thereof
|
WO2022204380A1
(en)
|
2021-03-24 |
2022-09-29 |
Modernatx, Inc. |
Lipid nanoparticles containing polynucleotides encoding propionyl-coa carboxylase alpha and beta subunits and uses thereof
|
WO2022204549A1
(en)
|
2021-03-25 |
2022-09-29 |
Translate Bio, Inc. |
Optimized nucleotide sequences encoding the extracellular domain of human ace2 protein or a portion thereof
|
KR20230160872A
(en)
|
2021-03-26 |
2023-11-24 |
미나 테라퓨틱스 리미티드 |
TMEM173 SARNA composition and methods of use
|
CN117377491A
(en)
|
2021-03-26 |
2024-01-09 |
葛兰素史克生物有限公司 |
Immunogenic compositions
|
AR125230A1
(en)
|
2021-03-29 |
2023-06-28 |
Alnylam Pharmaceuticals Inc |
COMPOSITIONS OF ANTI-HUNTINGTIN (HTT) RNAi AGENTS AND THEIR METHODS OF USE
|
CA3171429A1
(en)
|
2021-03-31 |
2022-09-30 |
Alexander SCHWENGER |
Syringes containing pharmaceutical compositions comprising rna
|
KR20230165276A
(en)
|
2021-03-31 |
2023-12-05 |
플래그쉽 파이어니어링 이노베이션스 브이, 인크. |
Thanotransmission polypeptides and their use in the treatment of cancer
|
WO2022212711A2
(en)
|
2021-04-01 |
2022-10-06 |
Modernatx, Inc. |
Methods for identification and ratio determination of rna species in multivalent rna compositions
|
EP4314293A1
(en)
|
2021-04-01 |
2024-02-07 |
Alnylam Pharmaceuticals, Inc. |
Proline dehydrogenase 2 (prodh2) irna compositions and methods of use thereof
|
TW202309002A
(en)
|
2021-04-15 |
2023-03-01 |
美商轉譯生技公司 |
"good" buffer-based cationic lipids
|
WO2022225918A1
(en)
|
2021-04-19 |
2022-10-27 |
Translate Bio, Inc. |
Improved compositions for delivery of mrna
|
WO2022223556A1
(en)
|
2021-04-20 |
2022-10-27 |
Anjarium Biosciences Ag |
Compositions of dna molecules encoding amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase, methods of making thereof, and methods of use thereof
|
US20220370616A1
(en)
|
2021-04-23 |
2022-11-24 |
Modernatx, Inc. |
Stabilized formulations
|
TW202308658A
(en)
|
2021-04-23 |
2023-03-01 |
美商現代公司 |
Isoquinoline-stabilized lipid nanoparticle formulations
|
TW202309280A
(en)
|
2021-04-26 |
2023-03-01 |
美商艾拉倫製藥股份有限公司 |
Transmembrane protease, serine 6 (tmprss6) irna compositions and methods of use thereof
|
IL308404A
(en)
|
2021-04-27 |
2024-01-01 |
Generation Bio Co |
Non-viral dna vectors expressing therapeutic antibodies and uses thereof
|
EP4329884A1
(en)
|
2021-04-27 |
2024-03-06 |
Generation Bio Co. |
Non-viral dna vectors expressing anti-coronavirus antibodies and uses thereof
|
EP4329731A1
(en)
|
2021-04-29 |
2024-03-06 |
ModernaTX, Inc. |
Lyophilization methods for preparing lipid formulated therapeutics
|
EP4330396A1
(en)
|
2021-04-29 |
2024-03-06 |
Alnylam Pharmaceuticals, Inc. |
Signal transducer and activator of transcription factor 6 (stat6) irna compositions and methods of use thereof
|
WO2022233880A1
(en)
|
2021-05-03 |
2022-11-10 |
Curevac Ag |
Improved nucleic acid sequence for cell type specific expression
|
WO2022240806A1
(en)
|
2021-05-11 |
2022-11-17 |
Modernatx, Inc. |
Non-viral delivery of dna for prolonged polypeptide expression in vivo
|
EP4341401A1
(en)
|
2021-05-18 |
2024-03-27 |
Alnylam Pharmaceuticals, Inc. |
Sodium-glucose cotransporter-2 (sglt2) irna compositions and methods of use thereof
|
WO2022246020A1
(en)
|
2021-05-19 |
2022-11-24 |
Modernatx, Inc. |
Polynucleotides encoding methylmalonyl-coa mutase for the treatment of methylmalonic acidemia
|
WO2022246023A1
(en)
|
2021-05-20 |
2022-11-24 |
Korro Bio, Inc. |
Methods and compositions for adar-mediated editing
|
CN113546180A
(en)
*
|
2021-05-25 |
2021-10-26 |
重庆医科大学 |
Gene delivery vector with myocardial targeting and preparation method thereof
|
EP4347554A1
(en)
*
|
2021-05-28 |
2024-04-10 |
Nanovation Therapeutics Inc. |
Mc3-type lipids and use thereof in the preparation of lipid nanoparticles
|
WO2022256283A2
(en)
|
2021-06-01 |
2022-12-08 |
Korro Bio, Inc. |
Methods for restoring protein function using adar
|
WO2022256395A1
(en)
|
2021-06-02 |
2022-12-08 |
Alnylam Pharmaceuticals, Inc. |
Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
|
AU2022283796A1
(en)
|
2021-06-04 |
2023-11-09 |
Alnylam Pharmaceuticals, Inc. |
HUMAN CHROMOSOME 9 OPEN READING FRAME 72 (C9ORF72) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
|
AR126070A1
(en)
|
2021-06-08 |
2023-09-06 |
Alnylam Pharmaceuticals Inc |
COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING STARGARDT DISEASE AND/OR DISORDERS ASSOCIATED WITH RETINOL BORDER PROTEIN 4 (RBP4)
|
WO2022260772A1
(en)
*
|
2021-06-09 |
2022-12-15 |
Carnegie Mellon University |
Lipid nanoparticle formulations for gastrointestinal delivery
|
EP4355882A2
(en)
|
2021-06-15 |
2024-04-24 |
Modernatx, Inc. |
Engineered polynucleotides for cell-type or microenvironment-specific expression
|
WO2022271776A1
(en)
|
2021-06-22 |
2022-12-29 |
Modernatx, Inc. |
Polynucleotides encoding uridine diphosphate glycosyltransferase 1 family, polypeptide a1 for the treatment of crigler-najjar syndrome
|
KR102516680B1
(en)
*
|
2021-06-24 |
2023-04-03 |
주식회사 테르나테라퓨틱스 |
Lipid Nano-particles and Method of Preparing the Same
|
WO2022270941A1
(en)
*
|
2021-06-24 |
2022-12-29 |
주식회사 테르나테라퓨틱스 |
Lipid nanoparticles and method for preparing same
|
WO2023278410A1
(en)
|
2021-06-29 |
2023-01-05 |
Korro Bio, Inc. |
Methods and compositions for adar-mediated editing
|
US20230194709A9
(en)
|
2021-06-29 |
2023-06-22 |
Seagate Technology Llc |
Range information detection using coherent pulse sets with selected waveform characteristics
|
KR20240026203A
(en)
|
2021-06-30 |
2024-02-27 |
알닐람 파마슈티칼스 인코포레이티드 |
Methods and compositions for treating angiotensinogen (AGT)-related disorders
|
WO2023278754A1
(en)
|
2021-07-01 |
2023-01-05 |
Translate Bio, Inc. |
Compositions for delivery of mrna
|
AU2022301302A1
(en)
|
2021-07-01 |
2024-01-25 |
Indapta Therapeutics, Inc. |
Engineered natural killer (nk) cells and related methods
|
WO2023283359A2
(en)
|
2021-07-07 |
2023-01-12 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating secreted frizzled receptor protein 1 (sfrp1) gene expression
|
WO2023283403A2
(en)
|
2021-07-09 |
2023-01-12 |
Alnylam Pharmaceuticals, Inc. |
Bis-rnai compounds for cns delivery
|
WO2023287751A1
(en)
|
2021-07-12 |
2023-01-19 |
Modernatx, Inc. |
Polynucleotides encoding propionyl-coa carboxylase alpha and beta subunits for the treatment of propionic acidemia
|
IL309897A
(en)
|
2021-07-21 |
2024-03-01 |
Alnylam Pharmaceuticals Inc |
Metabolic disorder-associated target gene irna compositions and methods of use thereof
|
WO2023003995A1
(en)
|
2021-07-23 |
2023-01-26 |
Alnylam Pharmaceuticals, Inc. |
Beta-catenin (ctnnb1) irna compositions and methods of use thereof
|
WO2023009547A1
(en)
|
2021-07-26 |
2023-02-02 |
Flagship Pioneering Innovations Vi, Llc |
Trem compositions and uses thereof
|
AU2022318949A1
(en)
|
2021-07-27 |
2024-02-29 |
Stand Therapeutics Co., Ltd. |
Peptide tag and nucleic acid encoding same
|
WO2023009499A1
(en)
|
2021-07-27 |
2023-02-02 |
Modernatx, Inc. |
Polynucleotides encoding glucose-6-phosphatase for the treatment of glycogen storage disease type 1a (gsd1a)
|
WO2023009687A1
(en)
|
2021-07-29 |
2023-02-02 |
Alnylam Pharmaceuticals, Inc. |
3-hydroxy-3-methylglutaryl-coa reductase (hmgcr) irna compositions and methods of use thereof
|
AU2022318664A1
(en)
|
2021-07-30 |
2024-02-29 |
Tune Therapeutics, Inc. |
Compositions and methods for modulating expression of methyl-cpg binding protein 2 (mecp2)
|
CA3171750A1
(en)
|
2021-07-30 |
2023-02-02 |
Tim SONNTAG |
Mrnas for treatment or prophylaxis of liver diseases
|
CA3227103A1
(en)
|
2021-07-30 |
2023-02-02 |
Matthew P. GEMBERLING |
Compositions and methods for modulating expression of frataxin (fxn)
|
WO2023014649A1
(en)
|
2021-08-02 |
2023-02-09 |
Modernatx, Inc. |
Extraction-less reverse phase (rp) chromatography of mrna encapsulated in lipid nanoparticles for mrna purity assessment
|
TW202328445A
(en)
|
2021-08-03 |
2023-07-16 |
美商艾拉倫製藥股份有限公司 |
Transthyretin (ttr) irna compositions and methods of use thereof
|
CA3228255A1
(en)
|
2021-08-04 |
2023-02-09 |
Alnylam Pharmaceuticals, Inc. |
Irna compositions and methods for silencing angiotensinogen (agt)
|
WO2023015261A1
(en)
|
2021-08-04 |
2023-02-09 |
Modernatx, Inc. |
Mrnas encoding chimeric metabolic reprogramming polypeptides and uses thereof
|
WO2023014974A1
(en)
|
2021-08-06 |
2023-02-09 |
University Of Iowa Research Foundation |
Double stranded mrna vaccines
|
WO2023018773A1
(en)
|
2021-08-11 |
2023-02-16 |
Modernatx, Inc. |
Lipid nanoparticle formulations and methods of synthesis thereof
|
WO2023019181A1
(en)
|
2021-08-11 |
2023-02-16 |
Modernatx, Inc. |
Sars-cov-2 lipid nanoparticle vaccine formulations
|
AU2022328347A1
(en)
|
2021-08-13 |
2024-02-08 |
Alnylam Pharmaceuticals, Inc. |
Factor xii (f12) irna compositions and methods of use thereof
|
IL309505A
(en)
|
2021-09-03 |
2024-02-01 |
CureVac SE |
Novel lipid nanoparticles for delivery of nucleic acids
|
AU2022336664A1
(en)
|
2021-09-03 |
2024-01-18 |
CureVac SE |
Novel lipid nanoparticles for delivery of nucleic acids comprising phosphatidylserine
|
WO2023031855A1
(en)
|
2021-09-03 |
2023-03-09 |
Glaxosmithkline Biologicals Sa |
Substitution of nucleotide bases in self-amplifying messenger ribonucleic acids
|
WO2023044370A2
(en)
|
2021-09-17 |
2023-03-23 |
Alnylam Pharmaceuticals, Inc. |
Irna compositions and methods for silencing complement component 3 (c3)
|
WO2023044006A1
(en)
|
2021-09-17 |
2023-03-23 |
Flagship Pioneering Innovations Vi, Llc |
Compositions and methods for producing circular polyribonucleotides
|
AU2022345881A1
(en)
|
2021-09-20 |
2024-03-21 |
Alnylam Pharmaceuticals, Inc. |
Inhibin subunit beta e (inhbe) modulator compositions and methods of use thereof
|
WO2023056044A1
(en)
|
2021-10-01 |
2023-04-06 |
Modernatx, Inc. |
Polynucleotides encoding relaxin for the treatment of fibrosis and/or cardiovascular disease
|
WO2023056401A1
(en)
|
2021-10-01 |
2023-04-06 |
Modernatx, Inc. |
Rna formulations for high volume distribution, and methods of using the same for treating a disease or condition caused by or associated with human cytomegalovirus
|
WO2023064469A1
(en)
|
2021-10-13 |
2023-04-20 |
Modernatx, Inc. |
Compositions of mrna-encoded il15 fusion proteins and methods of use thereof
|
AU2022364838A1
(en)
|
2021-10-15 |
2024-04-11 |
Alnylam Pharmaceuticals, Inc. |
Extra-hepatic delivery irna compositions and methods of use thereof
|
WO2023069397A1
(en)
|
2021-10-18 |
2023-04-27 |
Flagship Pioneering Innovations Vi, Llc |
Compositions and methods for purifying polyribonucleotides
|
WO2023069895A1
(en)
|
2021-10-18 |
2023-04-27 |
Modernatx, Inc. |
Markerless dna production
|
CA3234835A1
(en)
|
2021-10-22 |
2023-04-27 |
Korro Bio, Inc. |
Methods and compositions for disrupting nrf2-keap1 protein interaction by adar mediated rna editing
|
WO2023073534A1
(en)
|
2021-10-26 |
2023-05-04 |
Astrazeneca Ab |
Novel lipids for delivery of nucleic acid segments
|
WO2023076450A2
(en)
|
2021-10-29 |
2023-05-04 |
Alnylam Pharmaceuticals, Inc. |
HUNTINGTIN (HTT) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
|
CA3234636A1
(en)
|
2021-10-29 |
2023-05-04 |
Alnylam Pharmaceuticals, Inc. |
Complement factor b (cfb) irna compositions and methods of use thereof
|
WO2023073228A1
(en)
|
2021-10-29 |
2023-05-04 |
CureVac SE |
Improved circular rna for expressing therapeutic proteins
|
WO2023077170A1
(en)
|
2021-11-01 |
2023-05-04 |
Modernatx, Inc. |
Polynucleotides encoding integrin beta-6 and methods of use thereof
|
WO2023081526A1
(en)
|
2021-11-08 |
2023-05-11 |
Orna Therapeutics, Inc. |
Lipid nanoparticle compositions for delivering circular polynucleotides
|
KR20230068047A
(en)
|
2021-11-10 |
2023-05-17 |
주식회사 에스엠엘바이오팜 |
A pharmaceutical composition of lipid nano particle for delivering nucleic acid drug comprising trehalose derivitive and novel structural lipid compound
|
WO2023086893A1
(en)
|
2021-11-10 |
2023-05-19 |
Translate Bio, Inc. |
Composition and methods for treatment of primary ciliary dyskinesia
|
WO2023092060A1
(en)
|
2021-11-18 |
2023-05-25 |
Cornell University |
Microrna-dependent mrna switches for tissue-specific mrna-based therapies
|
WO2023089522A1
(en)
|
2021-11-18 |
2023-05-25 |
Astrazeneca Ab |
Novel lipids for delivery of nucleic acid segments
|
WO2023092151A1
(en)
*
|
2021-11-22 |
2023-05-25 |
Ohio State Innovation Foundation |
Compositions and methods for the treatment of neurodegenerative disorders
|
WO2023096963A1
(en)
|
2021-11-24 |
2023-06-01 |
Flagship Pioneering Innovations Vi, Llc |
Varicella-zoster virus immunogen compositions and their uses
|
WO2023096990A1
(en)
|
2021-11-24 |
2023-06-01 |
Flagship Pioneering Innovation Vi, Llc |
Coronavirus immunogen compositions and their uses
|
WO2023097003A2
(en)
|
2021-11-24 |
2023-06-01 |
Flagship Pioneering Innovations Vi, Llc |
Immunogenic compositions and their uses
|
WO2023099884A1
(en)
|
2021-12-01 |
2023-06-08 |
Mina Therapeutics Limited |
Pax6 sarna compositions and methods of use
|
WO2023107999A2
(en)
|
2021-12-08 |
2023-06-15 |
Modernatx, Inc. |
Herpes simplex virus mrna vaccines
|
GB202117758D0
(en)
|
2021-12-09 |
2022-01-26 |
Ucl Business Ltd |
Therapeutics for the treatment of neurodegenerative disorders
|
WO2023114307A1
(en)
|
2021-12-15 |
2023-06-22 |
Modernatx, Inc. |
Determination of encapsulation efficiency of lipid nanoparticles
|
WO2023114889A1
(en)
|
2021-12-16 |
2023-06-22 |
Modernatx, Inc. |
Processes for preparing lipid nanoparticles
|
WO2023122745A1
(en)
|
2021-12-22 |
2023-06-29 |
Flagship Pioneering Innovations Vi, Llc |
Compositions and methods for purifying polyribonucleotides
|
WO2023122762A1
(en)
|
2021-12-22 |
2023-06-29 |
Camp4 Therapeutics Corporation |
Modulation of gene transcription using antisense oligonucleotides targeting regulatory rnas
|
WO2023122789A1
(en)
|
2021-12-23 |
2023-06-29 |
Flagship Pioneering Innovations Vi, Llc |
Circular polyribonucleotides encoding antifusogenic polypeptides
|
WO2023133595A2
(en)
|
2022-01-10 |
2023-07-13 |
Sana Biotechnology, Inc. |
Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
|
CN114044741B
(en)
|
2022-01-13 |
2022-04-15 |
北京悦康科创医药科技股份有限公司 |
Cationic lipid compound, composition containing same and application
|
WO2023135273A2
(en)
|
2022-01-14 |
2023-07-20 |
Anjarium Biosciences Ag |
Compositions of dna molecules encoding factor viii, methods of making thereof, and methods of use thereof
|
WO2023135298A1
(en)
|
2022-01-17 |
2023-07-20 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods of inducing cell death of a population of solid tumor cells
|
WO2023141314A2
(en)
|
2022-01-24 |
2023-07-27 |
Alnylam Pharmaceuticals, Inc. |
Heparin sulfate biosynthesis pathway enzyme irna agent compositions and methods of use thereof
|
WO2023144193A1
(en)
|
2022-01-25 |
2023-08-03 |
CureVac SE |
Mrnas for treatment of hereditary tyrosinemia type i
|
WO2023147090A1
(en)
|
2022-01-27 |
2023-08-03 |
BioNTech SE |
Pharmaceutical compositions for delivery of herpes simplex virus antigens and related methods
|
WO2023144330A1
(en)
|
2022-01-28 |
2023-08-03 |
CureVac SE |
Nucleic acid encoded transcription factor inhibitors
|
WO2023150647A1
(en)
|
2022-02-02 |
2023-08-10 |
Sana Biotechnology, Inc. |
Methods of repeat dosing and administration of lipid particles or viral vectors and related systems and uses
|
WO2023152365A1
(en)
|
2022-02-14 |
2023-08-17 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Use of the 15-lipoxygenase for the treatment of lymphedema
|
WO2023159197A1
(en)
|
2022-02-18 |
2023-08-24 |
Modernatx, Inc. |
Mrnas encoding checkpoint cancer vaccines and uses thereof
|
WO2023161350A1
(en)
|
2022-02-24 |
2023-08-31 |
Io Biotech Aps |
Nucleotide delivery of cancer therapy
|
WO2023170435A1
(en)
|
2022-03-07 |
2023-09-14 |
Mina Therapeutics Limited |
Il10 sarna compositions and methods of use
|
WO2023177655A1
(en)
|
2022-03-14 |
2023-09-21 |
Generation Bio Co. |
Heterologous prime boost vaccine compositions and methods of use
|
TW202345835A
(en)
|
2022-03-16 |
2023-12-01 |
美商轉譯生技公司 |
Asymmetric piperazine-based cationic lipids
|
WO2023177904A1
(en)
|
2022-03-18 |
2023-09-21 |
Modernatx, Inc. |
Sterile filtration of lipid nanoparticles and filtration analysis thereof for biological applications
|
WO2023183909A2
(en)
|
2022-03-25 |
2023-09-28 |
Modernatx, Inc. |
Polynucleotides encoding fanconi anemia, complementation group proteins for the treatment of fanconi anemia
|
WO2023193002A1
(en)
|
2022-04-01 |
2023-10-05 |
Modernatx, Inc. |
Cross mixers for lipid nanoparticle production, and methods of operating the same
|
WO2023196399A1
(en)
|
2022-04-06 |
2023-10-12 |
Modernatx, Inc. |
Lipid nanoparticles and polynucleotides encoding argininosuccinate lyase for the treatment of argininosuccinic aciduria
|
WO2023196988A1
(en)
|
2022-04-07 |
2023-10-12 |
Modernatx, Inc. |
Methods of use of mrnas encoding il-12
|
WO2023196634A2
(en)
|
2022-04-08 |
2023-10-12 |
Flagship Pioneering Innovations Vii, Llc |
Vaccines and related methods
|
WO2023200893A1
(en)
*
|
2022-04-13 |
2023-10-19 |
Oregon State University |
Small molecule enhancers of antisense oligo activity
|
WO2023198857A1
(en)
|
2022-04-13 |
2023-10-19 |
Sanofi |
"good" buffer-based cationic lipids
|
WO2023201296A1
(en)
|
2022-04-15 |
2023-10-19 |
Modernatx, Inc. |
Ribosomal engagement potency assay
|
WO2023212696A1
(en)
|
2022-04-29 |
2023-11-02 |
Modernatx, Inc. |
Lyophilized human cytomegalovirus vaccines
|
WO2023215498A2
(en)
|
2022-05-05 |
2023-11-09 |
Modernatx, Inc. |
Compositions and methods for cd28 antagonism
|
WO2023220083A1
(en)
|
2022-05-09 |
2023-11-16 |
Flagship Pioneering Innovations Vi, Llc |
Trem compositions and methods of use for treating proliferative disorders
|
WO2023220729A2
(en)
|
2022-05-13 |
2023-11-16 |
Flagship Pioneering Innovations Vii, Llc |
Double stranded dna compositions and related methods
|
WO2023220734A2
(en)
*
|
2022-05-13 |
2023-11-16 |
The Trustees Of The University Of Pennsylvania |
Bisphosphonate lipids, lipid nanoparticle compositions comprising the same, and methods of use thereof for targeted delivery
|
WO2023218420A1
(en)
|
2022-05-13 |
2023-11-16 |
Janssen Pharmaceuticals, Inc. |
Mrna compositions for inducing latent hiv-1 reversal
|
WO2023227608A1
(en)
|
2022-05-25 |
2023-11-30 |
Glaxosmithkline Biologicals Sa |
Nucleic acid based vaccine encoding an escherichia coli fimh antigenic polypeptide
|
WO2023230601A1
(en)
|
2022-05-27 |
2023-11-30 |
Beam Therapeutics Inc. |
Identification of nanoparticles for preferential tissue or cell targeting
|
WO2023239756A1
(en)
|
2022-06-07 |
2023-12-14 |
Generation Bio Co. |
Lipid nanoparticle compositions and uses thereof
|
WO2023240277A2
(en)
|
2022-06-10 |
2023-12-14 |
Camp4 Therapeutics Corporation |
Methods of modulating progranulin expression using antisense oligonucleotides targeting regulatory rnas
|
CN117263818A
(en)
*
|
2022-06-14 |
2023-12-22 |
杭州高田生物医药有限公司 |
Cationic lipid compound, and preparation method and application thereof
|
WO2023242817A2
(en)
|
2022-06-18 |
2023-12-21 |
Glaxosmithkline Biologicals Sa |
Recombinant rna molecules comprising untranslated regions or segments encoding spike protein from the omicron strain of severe acute respiratory coronavirus-2
|
WO2023250112A1
(en)
|
2022-06-22 |
2023-12-28 |
Flagship Pioneering Innovations Vi, Llc |
Compositions of modified trems and uses thereof
|
WO2023250511A2
(en)
|
2022-06-24 |
2023-12-28 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for reducing low-density lipoprotein through targeted gene repression
|
WO2024007020A1
(en)
|
2022-06-30 |
2024-01-04 |
Indapta Therapeutics, Inc. |
Combination of engineered natural killer (nk) cells and antibody therapy and related methods
|
WO2024015881A2
(en)
|
2022-07-12 |
2024-01-18 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for targeted transcriptional activation
|
WO2024015890A1
(en)
|
2022-07-13 |
2024-01-18 |
Modernatx, Inc. |
Norovirus mrna vaccines
|
WO2024023034A1
(en)
|
2022-07-25 |
2024-02-01 |
Institut National de la Santé et de la Recherche Médicale |
Use of apelin for the treatment of lymphedema
|
WO2024026254A1
(en)
|
2022-07-26 |
2024-02-01 |
Modernatx, Inc. |
Engineered polynucleotides for temporal control of expression
|
WO2024026482A1
(en)
|
2022-07-29 |
2024-02-01 |
Modernatx, Inc. |
Lipid nanoparticle compositions comprising surface lipid derivatives and related uses
|
WO2024026475A1
(en)
|
2022-07-29 |
2024-02-01 |
Modernatx, Inc. |
Compositions for delivery to hematopoietic stem and progenitor cells (hspcs) and related uses
|
WO2024026487A1
(en)
|
2022-07-29 |
2024-02-01 |
Modernatx, Inc. |
Lipid nanoparticle compositions comprising phospholipid derivatives and related uses
|
WO2024030369A1
(en)
|
2022-08-01 |
2024-02-08 |
Modernatx, Inc. |
Extraction-less reverse phase (rp) chromatography for mrna purity assessment
|
WO2024030856A2
(en)
|
2022-08-01 |
2024-02-08 |
Flagship Pioneering Innovations Vii, Llc |
Immunomodulatory proteins and related methods
|
WO2024035952A1
(en)
|
2022-08-12 |
2024-02-15 |
Remix Therapeutics Inc. |
Methods and compositions for modulating splicing at alternative splice sites
|
WO2024039776A2
(en)
|
2022-08-18 |
2024-02-22 |
Alnylam Pharmaceuticals, Inc. |
Universal non-targeting sirna compositions and methods of use thereof
|
WO2024040254A2
(en)
|
2022-08-19 |
2024-02-22 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for regulation of hepatitis b virus through targeted gene repression
|
WO2024040222A1
(en)
|
2022-08-19 |
2024-02-22 |
Generation Bio Co. |
Cleavable closed-ended dna (cedna) and methods of use thereof
|
WO2024044147A1
(en)
|
2022-08-23 |
2024-02-29 |
Modernatx, Inc. |
Methods for purification of ionizable lipids
|
EP4327829A1
(en)
|
2022-08-26 |
2024-02-28 |
Ethris GmbH |
Stabilization of lipid or lipidoid nanoparticle suspensions
|
WO2024042236A1
(en)
|
2022-08-26 |
2024-02-29 |
Ethris Gmbh |
Stable lipid or lipidoid nanoparticle suspensions
|
WO2024050483A1
(en)
|
2022-08-31 |
2024-03-07 |
Modernatx, Inc. |
Variant strain-based coronavirus vaccines and uses thereof
|
WO2024047247A1
(en)
|
2022-09-02 |
2024-03-07 |
Institut National de la Santé et de la Recherche Médicale |
Base editing approaches for the treatment of amyotrophic lateral sclerosis
|
WO2024059165A1
(en)
|
2022-09-15 |
2024-03-21 |
Alnylam Pharmaceuticals, Inc. |
17b-hydroxysteroid dehydrogenase type 13 (hsd17b13) irna compositions and methods of use thereof
|
WO2024064642A2
(en)
|
2022-09-19 |
2024-03-28 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for modulating t cell function
|
WO2024064931A1
(en)
|
2022-09-23 |
2024-03-28 |
BioNTech SE |
Compositions for delivery of liver stage antigens and related methods
|
WO2024064934A1
(en)
|
2022-09-23 |
2024-03-28 |
BioNTech SE |
Compositions for delivery of plasmodium csp antigens and related methods
|
WO2024063788A1
(en)
|
2022-09-23 |
2024-03-28 |
BioNTech SE |
Compositions for delivery of malaria antigens and related methods
|
WO2024063789A1
(en)
|
2022-09-23 |
2024-03-28 |
BioNTech SE |
Compositions for delivery of malaria antigens and related methods
|
WO2024068545A1
(en)
|
2022-09-26 |
2024-04-04 |
Glaxosmithkline Biologicals Sa |
Influenza virus vaccines
|
WO2024077191A1
(en)
|
2022-10-05 |
2024-04-11 |
Flagship Pioneering Innovations V, Inc. |
Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer
|