CN1059445C - 红霉素的新型衍生物,其制备方法及作为药物的应用 - Google Patents

红霉素的新型衍生物,其制备方法及作为药物的应用 Download PDF

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Publication number
CN1059445C
CN1059445C CN95190283A CN95190283A CN1059445C CN 1059445 C CN1059445 C CN 1059445C CN 95190283 A CN95190283 A CN 95190283A CN 95190283 A CN95190283 A CN 95190283A CN 1059445 C CN1059445 C CN 1059445C
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CN
China
Prior art keywords
formula
compound
methyl
oxygen
dideoxy
Prior art date
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Expired - Lifetime
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CN95190283A
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English (en)
Chinese (zh)
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CN1126997A (zh
Inventor
C·阿古里达斯
Ｙ·本尼迪蒂
J·F·尚托特
A·丹尼斯
O·勒马特雷特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Aventis Pharma SA
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Roussel Uclaf SA
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Publication of CN1126997A publication Critical patent/CN1126997A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN95190283A 1994-04-08 1995-04-06 红霉素的新型衍生物,其制备方法及作为药物的应用 Expired - Lifetime CN1059445C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR94/04154 1994-04-08
FR9404154A FR2718450B1 (fr) 1994-04-08 1994-04-08 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Publications (2)

Publication Number Publication Date
CN1126997A CN1126997A (zh) 1996-07-17
CN1059445C true CN1059445C (zh) 2000-12-13

Family

ID=9461886

Family Applications (1)

Application Number Title Priority Date Filing Date
CN95190283A Expired - Lifetime CN1059445C (zh) 1994-04-08 1995-04-06 红霉素的新型衍生物,其制备方法及作为药物的应用

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US (2) US5656607A (https=)
EP (1) EP0676409B1 (https=)
JP (1) JP3000023B2 (https=)
KR (1) KR100317148B1 (https=)
CN (1) CN1059445C (https=)
AP (1) AP587A (https=)
AT (1) ATE234853T1 (https=)
AU (1) AU684939B2 (https=)
BG (1) BG61916B1 (https=)
BR (1) BR9506147A (https=)
CA (1) CA2164638C (https=)
CO (1) CO4370097A1 (https=)
CZ (1) CZ296005B6 (https=)
DE (1) DE69529934T2 (https=)
DK (1) DK0676409T3 (https=)
DZ (1) DZ1869A1 (https=)
EE (1) EE04498B1 (https=)
ES (1) ES2189820T3 (https=)
FI (1) FI111264B (https=)
FR (1) FR2718450B1 (https=)
GB (1) GB2288174A (https=)
GE (1) GEP19991836B (https=)
HR (1) HRP950217B1 (https=)
HU (1) HU215396B (https=)
IL (1) IL112954A (https=)
IS (1) IS1865B (https=)
JO (1) JO1850B1 (https=)
LV (1) LV11182B (https=)
MA (1) MA23501A1 (https=)
MD (1) MD663G2 (https=)
MY (1) MY114672A (https=)
NO (1) NO308361B1 (https=)
NZ (1) NZ284498A (https=)
OA (1) OA10200A (https=)
PE (1) PE2896A1 (https=)
PL (1) PL180837B1 (https=)
PT (1) PT676409E (https=)
RO (1) RO115634B1 (https=)
RU (1) RU2141965C1 (https=)
SA (1) SA97170757A (https=)
SI (1) SI0676409T1 (https=)
SK (1) SK284079B6 (https=)
SV (1) SV1995000018A (https=)
TN (1) TNSN95026A1 (https=)
TW (1) TW316908B (https=)
UA (1) UA44705C2 (https=)
WO (1) WO1995027720A1 (https=)
YU (1) YU49221B (https=)
ZA (1) ZA952059B (https=)

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FR2732023B1 (fr) * 1995-03-22 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2745289B1 (fr) * 1996-02-28 1998-05-29 Roussel Uclaf Nouveaux derives de l'acide 1(2h) quinoleine carboxylique, leur procede de preparation et leur application a la synthese de produits doues de proprietes antibiotiques
US5750510A (en) * 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
AU710532B2 (en) * 1996-05-07 1999-09-23 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
FR2748746B1 (fr) * 1996-05-14 1998-08-14 Hoechst Marion Roussel Inc Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine
FR2751656B1 (fr) * 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
DE69733422T2 (de) * 1996-09-04 2006-05-04 Abbott Laboratories, Abbott Park 6-0-substituierte ketoliden mit antibakteriellen wirkung
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
AU4472897A (en) * 1997-03-10 1998-09-29 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
US6140479A (en) * 1997-03-24 2000-10-31 Taisho Pharmaceuticals Co., Ltd. Erythromycin a derivatives
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FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
HRP980189B1 (en) * 1998-04-06 2004-04-30 Pliva Pharm & Chem Works Novel 15-membered lactams ketolides
ES2243066T3 (es) * 1998-09-22 2005-11-16 Pfizer Products Inc. Antibioticos de carbamato y carbazato cetolida.
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
DE69933897T2 (de) 1998-12-10 2007-03-15 Pfizer Products Inc., Groton Carbamat- und Carbazatketolid-Antibiotika
EP1298138B1 (en) * 1998-12-10 2006-11-02 Pfizer Products Inc. Carbamate and Carbazate Ketolide Antibiotics
EP1749832A3 (en) * 1998-12-10 2008-03-26 Pfizer Products Incorporated Carbamate and carbazate ketolide antibiotics
FR2789392B1 (fr) * 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
ATE340183T1 (de) * 1999-04-16 2006-10-15 Kosan Biosciences Inc Antiinfektiöse makrolidderivate
CA2370743A1 (en) 1999-04-16 2000-10-26 Dennis Hlasta Ketolide antibacterials
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
HUP0201516A3 (en) * 1999-05-24 2003-03-28 Pfizer Prod Inc 13-methyl-erythromycin derivatives, process for their preparation and pharmaceutical compositions containing them
CA2451391A1 (en) 2001-07-03 2003-01-16 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
US7332304B2 (en) 2002-07-01 2008-02-19 Arkion Life Sciences Llc Process and materials for production of glucosamine and N-acetylglucosamine
EP1638549A4 (en) * 2003-03-10 2011-06-15 Optimer Pharmaceuticals Inc NEW ANTIBACTERIAL AGENTS
CA2523134A1 (en) * 2003-04-25 2004-11-11 Chiron Corporation Pyridyl substituted ketolide antibiotics
US7163924B2 (en) * 2003-04-25 2007-01-16 Chiron Corporation Ketolide derivatives
EP2214484A4 (en) 2007-10-25 2013-01-02 Cempra Pharmaceuticals Inc PROCESS FOR PREPARING ANTIBACTERIAL MAKROLIDE AGENTS
JP5711135B2 (ja) 2008-10-24 2015-04-30 センプラ ファーマシューティカルズ，インコーポレイテッド 胃腸疾患を治療するための方法
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
ES2608285T3 (es) 2009-09-10 2017-04-07 Cempra Pharmaceuticals, Inc. Procedimientos para el tratamiento de paludismo, tuberculosis y enfermedades por MAC
MX361413B (es) 2010-03-22 2018-12-05 Cempra Pharmaceuticals Inc Star Formas cristalinas de un macrólido y usos para las mismas.
CN102917708B (zh) 2010-05-20 2015-11-25 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
EP2613630A4 (en) 2010-09-10 2014-01-15 Cempra Pharmaceuticals Inc HYDROGEN BOND FOR THE PREPARATION OF FLUOROCHETOLIDES FOR THE TREATMENT OF DISEASES
NZ700182A (en) 2012-03-27 2017-02-24 Cempra Pharmaceuticals Inc Parenteral formulations for administering macrolide antibiotics
AU2014239959A1 (en) 2013-03-14 2015-10-01 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
CN105188712A (zh) 2013-03-15 2015-12-23 森普拉制药公司 用于制备大环内酯抗菌剂的收敛方法
JP6437523B2 (ja) 2013-04-04 2018-12-12 プレジデント アンド フェローズ オブ ハーバード カレッジ マクロライドならびにそれらの調製および使用の方法
CN106998685A (zh) * 2014-10-08 2017-08-01 哈佛大学的校长及成员们 14‑元酮内酯及其制备和使用方法
EP3273969A4 (en) 2015-03-25 2018-11-21 President and Fellows of Harvard College Macrolides with modified desosamine sugars and uses thereof
MD1222Z (ro) * 2017-05-31 2018-08-31 ИНСТИТУТ ЭЛЕКТРОННОЙ ИНЖЕНЕРИИ И НАНОТЕХНОЛОГИЙ "D. Ghitu" АНМ Procedeu de tratare a materialului săditor al florilor înainte de plantare
JP7199722B2 (ja) 2019-12-25 2023-01-06 旭精工株式会社 硬貨搬送振分機構及びそれを備えた硬貨識別搬送装置

Citations (1)

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FR2692579A1 (fr) * 1992-06-19 1993-12-24 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.

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AT342770B (de) * 1975-04-07 1978-04-25 Thomae Gmbh Dr K Verfahren zur herstellung neuer erythromycinderivate
DE2842759A1 (de) * 1978-09-30 1980-04-10 Merck Patent Gmbh Basische aether, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung
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FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
FR2702480B1 (fr) * 1993-03-09 1995-04-28 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Patent Citations (1)

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Also Published As

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PL180837B1 (pl) 2001-04-30
FR2718450A1 (fr) 1995-10-13
EE04498B1 (et) 2005-06-15
MD663F1 (ro) 1997-01-31
SK154695A3 (en) 1996-10-02
RO115634B1 (ro) 2000-04-28
NO308361B1 (no) 2000-09-04
SI0676409T1 (en) 2003-06-30
MD663G2 (ro) 1997-07-31
YU21695A (sh) 1997-12-05
AP9500743A0 (en) 1995-07-31
UA44705C2 (uk) 2002-03-15
GB2288174A (en) 1995-10-11
JPH07278177A (ja) 1995-10-24
YU49221B (sh) 2004-11-25
IS1865B (is) 2003-05-02
SA97170757A (ar) 2005-12-03
IL112954A0 (en) 1995-06-29
GB9506856D0 (en) 1995-05-24
HRP950217B1 (en) 2004-06-30
NO954942L (no) 1996-02-07
EP0676409B1 (fr) 2003-03-19
JO1850B1 (en) 1995-12-27
EP0676409A1 (fr) 1995-10-11
KR100317148B1 (ko) 2002-06-22
MY114672A (en) 2002-12-31
LV11182A (lv) 1996-04-20
CO4370097A1 (es) 1996-10-07
FI955913A0 (fi) 1995-12-08
IL112954A (en) 2000-07-16
TW316908B (https=) 1997-10-01
BG100150A (bg) 1996-06-28
FR2718450B1 (fr) 1997-01-10
CA2164638A1 (fr) 1995-10-19
IS4309A (is) 1995-11-17
CZ296005B6 (cs) 2005-12-14
AU684939B2 (en) 1998-01-08
PE2896A1 (es) 1996-02-12
US5760233A (en) 1998-06-02
NZ284498A (en) 1997-07-27
WO1995027720A1 (fr) 1995-10-19
ZA952059B (en) 1996-03-13
NO954942D0 (no) 1995-12-06
PL311871A1 (en) 1996-03-18
EE9500080A (et) 1996-12-16
DZ1869A1 (fr) 2002-02-17
GEP19991836B (en) 1999-11-05
FI955913A7 (fi) 1995-12-08
HU9503505D0 (en) 1996-02-28
JP3000023B2 (ja) 2000-01-17
RU2141965C1 (ru) 1999-11-27
AU2310795A (en) 1995-10-30
CZ322395A3 (en) 1996-08-14
DE69529934T2 (de) 2003-09-04
US5656607A (en) 1997-08-12
BR9506147A (pt) 1996-04-16
LV11182B (en) 1997-04-20
MA23501A1 (fr) 1995-12-31
CN1126997A (zh) 1996-07-17
ES2189820T3 (es) 2003-07-16
TNSN95026A1 (fr) 1996-02-06
PT676409E (pt) 2003-08-29
OA10200A (fr) 1996-12-18
HU215396B (hu) 1998-12-28
DK0676409T3 (da) 2003-06-23
HUT73772A (en) 1996-09-30
SV1995000018A (es) 1997-10-24
AP587A (en) 1997-04-29
HRP950217A2 (en) 1997-08-31
FI111264B (fi) 2003-06-30
SK284079B6 (sk) 2004-09-08
DE69529934D1 (de) 2003-04-24
CA2164638C (fr) 2003-12-30
BG61916B1 (bg) 1998-09-30
ATE234853T1 (de) 2003-04-15

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