KR100317148B1 - 신규한에리트로마이신유도체,그의제조방법및약제로서의그의용도 - Google Patents

신규한에리트로마이신유도체,그의제조방법및약제로서의그의용도 Download PDF

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Publication number
KR100317148B1
KR100317148B1 KR1019950705537A KR19950705537A KR100317148B1 KR 100317148 B1 KR100317148 B1 KR 100317148B1 KR 1019950705537 A KR1019950705537 A KR 1019950705537A KR 19950705537 A KR19950705537 A KR 19950705537A KR 100317148 B1 KR100317148 B1 KR 100317148B1
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South Korea
Prior art keywords
methyl
formula
compound
radical
hydrogen atom
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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KR1019950705537A
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English (en)
Korean (ko)
Inventor
꽁스땅뗑 아구리다스
얀니끄 베네데띠
쟝-프랑소와 샹또
알렉시 데니
오딜르 르마르또레
Original Assignee
쟝-끌로드 비에이으포스
로우셀-우크라프
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Application granted granted Critical
Publication of KR100317148B1 publication Critical patent/KR100317148B1/ko
Assigned to 아벤티스 파마 소시에떼아노님 reassignment 아벤티스 파마 소시에떼아노님 권리의 전부이전등록 Assignors: 훽스트 마리온 로우셀
Assigned to 훽스트 마리온 로우셀 reassignment 훽스트 마리온 로우셀 권리의 전부이전등록 Assignors: 로우셀 우크라프
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1019950705537A 1994-04-08 1995-04-06 신규한에리트로마이신유도체,그의제조방법및약제로서의그의용도 Expired - Lifetime KR100317148B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR94/04154 1994-04-08
FR9404154A FR2718450B1 (fr) 1994-04-08 1994-04-08 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
PCT/FR1995/000441 WO1995027720A1 (fr) 1994-04-08 1995-04-06 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (1)

Publication Number Publication Date
KR100317148B1 true KR100317148B1 (ko) 2002-06-22

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KR1019950705537A Expired - Lifetime KR100317148B1 (ko) 1994-04-08 1995-04-06 신규한에리트로마이신유도체,그의제조방법및약제로서의그의용도

Country Status (49)

Country Link
US (2) US5656607A (https=)
EP (1) EP0676409B1 (https=)
JP (1) JP3000023B2 (https=)
KR (1) KR100317148B1 (https=)
CN (1) CN1059445C (https=)
AP (1) AP587A (https=)
AT (1) ATE234853T1 (https=)
AU (1) AU684939B2 (https=)
BG (1) BG61916B1 (https=)
BR (1) BR9506147A (https=)
CA (1) CA2164638C (https=)
CO (1) CO4370097A1 (https=)
CZ (1) CZ296005B6 (https=)
DE (1) DE69529934T2 (https=)
DK (1) DK0676409T3 (https=)
DZ (1) DZ1869A1 (https=)
EE (1) EE04498B1 (https=)
ES (1) ES2189820T3 (https=)
FI (1) FI111264B (https=)
FR (1) FR2718450B1 (https=)
GB (1) GB2288174A (https=)
GE (1) GEP19991836B (https=)
HR (1) HRP950217B1 (https=)
HU (1) HU215396B (https=)
IL (1) IL112954A (https=)
IS (1) IS1865B (https=)
JO (1) JO1850B1 (https=)
LV (1) LV11182B (https=)
MA (1) MA23501A1 (https=)
MD (1) MD663G2 (https=)
MY (1) MY114672A (https=)
NO (1) NO308361B1 (https=)
NZ (1) NZ284498A (https=)
OA (1) OA10200A (https=)
PE (1) PE2896A1 (https=)
PL (1) PL180837B1 (https=)
PT (1) PT676409E (https=)
RO (1) RO115634B1 (https=)
RU (1) RU2141965C1 (https=)
SA (1) SA97170757A (https=)
SI (1) SI0676409T1 (https=)
SK (1) SK284079B6 (https=)
SV (1) SV1995000018A (https=)
TN (1) TNSN95026A1 (https=)
TW (1) TW316908B (https=)
UA (1) UA44705C2 (https=)
WO (1) WO1995027720A1 (https=)
YU (1) YU49221B (https=)
ZA (1) ZA952059B (https=)

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FR2732023B1 (fr) * 1995-03-22 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2745289B1 (fr) * 1996-02-28 1998-05-29 Roussel Uclaf Nouveaux derives de l'acide 1(2h) quinoleine carboxylique, leur procede de preparation et leur application a la synthese de produits doues de proprietes antibiotiques
US5750510A (en) * 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
JP2002502366A (ja) * 1996-05-07 2002-01-22 アボット・ラボラトリーズ ３―デスクラジノース―２，３―無水エリスロマイシン誘導体
FR2748746B1 (fr) * 1996-05-14 1998-08-14 Hoechst Marion Roussel Inc Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine
FR2751656B1 (fr) * 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
DE69733723T2 (de) * 1996-09-04 2006-04-20 Abbott Laboratories, Abbott Park 6-o-Substituierte Ketoliden mit antibakteriellen Wirkung
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
WO1998040392A1 (fr) * 1997-03-10 1998-09-17 Taisho Pharmaceutical Co., Ltd. Derives d'erythromycine a
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WO1998051696A1 (en) * 1997-05-09 1998-11-19 Pfizer Products Inc. Erythromycin derivatives
US5922683A (en) * 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
CZ9904388A3 (cs) * 1997-06-11 2002-10-16 Pfizer Products Inc. 9-Oximové deriváty erythromycinu
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
HRP980189B1 (en) * 1998-04-06 2004-04-30 Pliva Pharm & Chem Works Novel 15-membered lactams ketolides
WO2000017218A1 (en) 1998-09-22 2000-03-30 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
EP1749832A3 (en) * 1998-12-10 2008-03-26 Pfizer Products Incorporated Carbamate and carbazate ketolide antibiotics
EP1298138B1 (en) * 1998-12-10 2006-11-02 Pfizer Products Inc. Carbamate and Carbazate Ketolide Antibiotics
TR200102129T2 (tr) 1998-12-10 2002-01-21 Pfizer Products Inc. Karbamat ve karbazat ketolid antibiyotikleri.
FR2789392B1 (fr) * 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
ID30547A (id) * 1999-04-16 2001-12-20 Kosan Biosciences Inc Zat anti-infeksi makrolida
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
IL145976A0 (en) 1999-04-16 2002-07-25 Ortho Mcneil Pharm Inc Ketolide antibacterials
EA200100983A1 (ru) * 1999-05-24 2002-10-31 Пфайзер Продактс Инк. Производные 13-метилэритромицина
WO2003004509A2 (en) * 2001-07-03 2003-01-16 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
KR101035043B1 (ko) 2002-07-01 2011-05-19 아르키온 라이프 사이언씨즈 엘엘씨 글루코사민 및 ｎ-아세틸글루코사민의 제조를 위한 물질및 공정
ES2552682T3 (es) 2003-03-10 2015-12-01 Merck Sharp & Dohme Corp. Agentes antibacterianos novedosos
US7163924B2 (en) * 2003-04-25 2007-01-16 Chiron Corporation Ketolide derivatives
US7332476B2 (en) * 2003-04-25 2008-02-19 Novartis Ag Pyridyl substituted ketolide antibiotics
CN105732745A (zh) 2007-10-25 2016-07-06 森普拉制药公司 大环内酯类抗菌剂的制备方法
AU2009308182B2 (en) * 2008-10-24 2016-05-19 Cempra Pharmaceuticals, Inc. Biodefenses using triazole-containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US9480679B2 (en) 2009-09-10 2016-11-01 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
DK2550286T3 (en) 2010-03-22 2016-02-29 Cempra Pharmaceuticals Inc CRYSTALLINE FORMS OF A MACROLID AND APPLICATIONS THEREOF
CN105198944B (zh) 2010-05-20 2018-06-01 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
EP2613630A4 (en) 2010-09-10 2014-01-15 Cempra Pharmaceuticals Inc HYDROGEN BOND FOR THE PREPARATION OF FLUOROCHETOLIDES FOR THE TREATMENT OF DISEASES
MX2014011537A (es) 2012-03-27 2015-02-10 Cempra Pharmaceuticals Inc Formulaciones parenterales para la administracion de antibioticos macrolidos.
HK1217665A1 (zh) 2013-03-14 2017-01-20 森普拉制药公司 用於治療呼吸道疾病的方法及其製劑
RU2015138797A (ru) 2013-03-15 2017-04-24 Семпра Фармасьютикалс, Инк. Конвергентные способы получения макролидных антибактериальных агентов
US9982005B2 (en) 2013-04-04 2018-05-29 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
US10633407B2 (en) 2014-10-08 2020-04-28 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
JP2018509452A (ja) 2015-03-25 2018-04-05 プレジデント アンド フェローズ オブ ハーバード カレッジ 修飾デソサミン糖をもつマクロライドおよびその使用
MD1222Z (ro) * 2017-05-31 2018-08-31 ИНСТИТУТ ЭЛЕКТРОННОЙ ИНЖЕНЕРИИ И НАНОТЕХНОЛОГИЙ "D. Ghitu" АНМ Procedeu de tratare a materialului săditor al florilor înainte de plantare
JP7199722B2 (ja) 2019-12-25 2023-01-06 旭精工株式会社 硬貨搬送振分機構及びそれを備えた硬貨識別搬送装置

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FR2692579B1 (fr) * 1992-06-19 1995-06-02 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.
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Also Published As

Publication number Publication date
HUT73772A (en) 1996-09-30
FI955913A7 (fi) 1995-12-08
CZ322395A3 (en) 1996-08-14
BG100150A (bg) 1996-06-28
CZ296005B6 (cs) 2005-12-14
HRP950217B1 (en) 2004-06-30
HU9503505D0 (en) 1996-02-28
SI0676409T1 (en) 2003-06-30
NZ284498A (en) 1997-07-27
DZ1869A1 (fr) 2002-02-17
LV11182A (lv) 1996-04-20
HU215396B (hu) 1998-12-28
AU2310795A (en) 1995-10-30
ATE234853T1 (de) 2003-04-15
AP587A (en) 1997-04-29
UA44705C2 (uk) 2002-03-15
SV1995000018A (es) 1997-10-24
WO1995027720A1 (fr) 1995-10-19
CA2164638C (fr) 2003-12-30
PL311871A1 (en) 1996-03-18
JP3000023B2 (ja) 2000-01-17
FR2718450A1 (fr) 1995-10-13
GB9506856D0 (en) 1995-05-24
EP0676409B1 (fr) 2003-03-19
JO1850B1 (en) 1995-12-27
MA23501A1 (fr) 1995-12-31
IS4309A (is) 1995-11-17
BR9506147A (pt) 1996-04-16
JPH07278177A (ja) 1995-10-24
LV11182B (en) 1997-04-20
FI955913A0 (fi) 1995-12-08
ES2189820T3 (es) 2003-07-16
YU49221B (sh) 2004-11-25
CA2164638A1 (fr) 1995-10-19
DK0676409T3 (da) 2003-06-23
PL180837B1 (pl) 2001-04-30
BG61916B1 (bg) 1998-09-30
HRP950217A2 (en) 1997-08-31
US5760233A (en) 1998-06-02
RO115634B1 (ro) 2000-04-28
AU684939B2 (en) 1998-01-08
IL112954A0 (en) 1995-06-29
SK154695A3 (en) 1996-10-02
AP9500743A0 (en) 1995-07-31
GEP19991836B (en) 1999-11-05
NO954942L (no) 1996-02-07
CN1126997A (zh) 1996-07-17
MD663G2 (ro) 1997-07-31
SA97170757A (ar) 2005-12-03
YU21695A (sh) 1997-12-05
MD663F1 (ro) 1997-01-31
IS1865B (is) 2003-05-02
NO954942D0 (no) 1995-12-06
PT676409E (pt) 2003-08-29
OA10200A (fr) 1996-12-18
TW316908B (https=) 1997-10-01
MY114672A (en) 2002-12-31
CO4370097A1 (es) 1996-10-07
FR2718450B1 (fr) 1997-01-10
EE04498B1 (et) 2005-06-15
ZA952059B (en) 1996-03-13
RU2141965C1 (ru) 1999-11-27
NO308361B1 (no) 2000-09-04
EP0676409A1 (fr) 1995-10-11
US5656607A (en) 1997-08-12
EE9500080A (et) 1996-12-16
TNSN95026A1 (fr) 1996-02-06
SK284079B6 (sk) 2004-09-08
DE69529934D1 (de) 2003-04-24
DE69529934T2 (de) 2003-09-04
CN1059445C (zh) 2000-12-13
PE2896A1 (es) 1996-02-12
IL112954A (en) 2000-07-16
GB2288174A (en) 1995-10-11
FI111264B (fi) 2003-06-30

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