CN102405286A - 减小大小的自递送RNAi化合物 - Google Patents

减小大小的自递送RNAi化合物 Download PDF

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Publication number
CN102405286A
CN102405286A CN2009801464922A CN200980146492A CN102405286A CN 102405286 A CN102405286 A CN 102405286A CN 2009801464922 A CN2009801464922 A CN 2009801464922A CN 200980146492 A CN200980146492 A CN 200980146492A CN 102405286 A CN102405286 A CN 102405286A
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nucleotides
strand
nucleic acid
guide strand
stranded
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阿纳斯塔西娅·赫沃罗娃
威廉·萨洛蒙
乔安妮·卡门斯
德米特里·萨马尔斯基
托德·M·伍尔夫
詹姆斯·卡迪亚
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Phio Pharmaceuticals Corp
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RXi Pharmaceuticals Corp
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Priority to CN201711334248.1A priority Critical patent/CN108165548B/zh
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CN2009801464922A 2008-09-22 2009-09-22 减小大小的自递送RNAi化合物 Pending CN102405286A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201711334248.1A CN108165548B (zh) 2008-09-22 2009-09-22 减小大小的自递送RNAi化合物

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US19295408P 2008-09-22 2008-09-22
US61/192,954 2008-09-22
US14994609P 2009-02-04 2009-02-04
US61/149,946 2009-02-04
US22403109P 2009-07-08 2009-07-08
US61/224,031 2009-07-08
PCT/US2009/005247 WO2010033247A2 (en) 2008-09-22 2009-09-22 Reduced size self-delivering rnai compounds

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CN201711334248.1A Division CN108165548B (zh) 2008-09-22 2009-09-22 减小大小的自递送RNAi化合物

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CN2009801464922A Pending CN102405286A (zh) 2008-09-22 2009-09-22 减小大小的自递送RNAi化合物

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US (12) US8796443B2 (enExample)
EP (5) EP3336188B1 (enExample)
JP (5) JP6209309B2 (enExample)
CN (2) CN108165548B (enExample)
AU (1) AU2009293658A1 (enExample)
CA (4) CA3027780C (enExample)
IL (1) IL211863A0 (enExample)
WO (3) WO2010033248A2 (enExample)

Cited By (8)

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CN104755620A (zh) * 2012-05-22 2015-07-01 奥利克斯医药有限公司 具有细胞内穿透能力的诱导rna干扰的核酸分子及其用途
CN106244590A (zh) * 2016-08-18 2016-12-21 广州市锐博生物科技有限公司 经修饰的siRNA分子、RNAi分子混合物及其应用
CN106498072A (zh) * 2016-11-24 2017-03-15 青岛千卓分子生物科技有限公司 一种液态产品中外源dna内标物的保护方法及其应用
CN108135923A (zh) * 2015-07-06 2018-06-08 阿克赛医药公司 靶向超氧化物歧化酶1（sod1）的核酸分子
CN112263587A (zh) * 2020-10-23 2021-01-26 河北仁博科技有限公司 miR-3065-5p在制备预防和/或治疗肾纤维化的药物中的应用
CN113151180A (zh) * 2013-12-02 2021-07-23 菲奥医药公司 癌症的免疫治疗
CN118526468A (zh) * 2023-03-29 2024-08-23 北京超环生物科技有限公司 一种负载核酸的脂质体纳米颗粒
CN121046387A (zh) * 2025-11-03 2025-12-02 谷雨生物科技集团股份有限公司 一种具有抗皮肤细胞衰老和修护功效的siRNA及其应用

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KR100949791B1 (ko) * 2007-12-18 2010-03-30 이동기 오프-타겟 효과를 최소화하고 ＲＮＡｉ 기구를 포화시키지않는 신규한 ｓｉＲＮＡ 구조 및 그 용도
CA2710388A1 (en) * 2007-12-21 2009-07-09 Coda Therapeutics, Inc. Use of anti-connexin polynucleotides for the treatment of abnormal or excessive scars
CN104975020B (zh) 2008-02-11 2020-01-17 菲奥医药公司 经修饰的RNAi多核苷酸及其用途
WO2010008582A2 (en) 2008-07-18 2010-01-21 Rxi Pharmaceuticals Corporation Phagocytic cell drug delivery system
MX2011002143A (es) 2008-08-25 2011-07-20 Excaliard Pharmaceuticals Inc Oligonucleotidos antisentido dirigidos contra el factor de crecimiento del tejido conectivo y usos de los mismos.
US8946172B2 (en) 2008-08-25 2015-02-03 Excaliard Pharmaceuticals, Inc. Method for reducing scarring during wound healing using antisense compounds directed to CTGF
US8796443B2 (en) * 2008-09-22 2014-08-05 Rxi Pharmaceuticals Corporation Reduced size self-delivering RNAi compounds
WO2010059226A2 (en) 2008-11-19 2010-05-27 Rxi Pharmaceuticals Corporation Inhibition of map4k4 through rnai
ES2629630T3 (es) * 2008-12-04 2017-08-11 Curna, Inc. Tratamiento de enfermedades relacionadas con eritropoyetina (EPO) mediante inhibición del transcrito antisentido natural a EPO
WO2010078536A1 (en) 2009-01-05 2010-07-08 Rxi Pharmaceuticals Corporation Inhibition of pcsk9 through rnai
WO2010090762A1 (en) * 2009-02-04 2010-08-12 Rxi Pharmaceuticals Corporation Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
WO2011109248A1 (en) 2010-03-02 2011-09-09 Hapten Pharmaceuticals, Llc Effective sensitizing dose of a gelled immunomodulating topical composition
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