CN102105068B - 益生菌补充剂及其制造方法和包装 - Google Patents
益生菌补充剂及其制造方法和包装 Download PDFInfo
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- CN102105068B CN102105068B CN200980125878.5A CN200980125878A CN102105068B CN 102105068 B CN102105068 B CN 102105068B CN 200980125878 A CN200980125878 A CN 200980125878A CN 102105068 B CN102105068 B CN 102105068B
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Classifications
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- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/04—Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, or spherical or like small articles, e.g. tablets or pills
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
- B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
- B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
- B65D75/36—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed
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- Composite Materials (AREA)
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Abstract
本发明提供了宠物食品组合物,所述宠物食品组合物包括补充剂。所述补充剂可包含益生菌组分、可可脂组分和甜味剂组分。本发明还提供了制造所述补充剂的方法,所述方法可包括:提供甜味剂组分、可可脂组分和益生菌组分;在具有受控温度和湿度的小室内混合所述可可脂组分和益生菌组分以形成混合物;在具有受控温度和湿度的小室内将所述混合物与所述甜味剂组分混合以形成最终的混合物;任选地将着色剂与所述最终的混合物混合;以及冷却所述最终的混合物。用于所述补充剂的包装可包括次级容器,所述次级容器容纳初级容器,所述初级容器容纳补充剂。此外,还提供了包装的排列。
Description
发明领域
本发明一般涉及包含作为宠物食品补充剂的益生菌组分的组合物、制造所述组合物的方法及其包装。更具体地讲,本发明涉及作为补充剂的宠物食品组合物、制造这种补充剂的方法、以及这种补充剂的包装,其中所述补充剂包含益生菌组分、甜味剂组分和脂肪组分。
发明背景
包含益生菌微生物的组合物是人们所期望的,尤其是在宠物食品领域。虽然进行了多种商业尝试来获得这些组合物,但许多这些组合物不能提供足够功效水平的活性或休眠状态的益生菌微生物,这是由于所述微生物不能经受标准商用宠物食品的制造过程。例如,对于具体的宠物食品组合物,已提出了用益生菌微生物包被或填充标准的宠物食品粗磨粒的努力,但这种努力在实践中往往被证明是不可行的。为了避免标准商用食品制造过程中的问题,其他制造商可能提供装有益生菌微生物粉末的瓶子来用于将粉末撒在标准宠物食品上。然而,这种方法带来了便利性和依从性方面的问题,因此有必要在该领域进行更进一步的开发以获得能够在市场上取得成功并被广泛用于人和宠物的有效组合物及其制造方法。此外,粉末形态的益生菌微生物是不够稳定的,因为粉末形态一旦暴露于外界环境,环境中的水分就会促进益生菌微生物的过早激活。
因此,需要一种处于非常稳定形态的益生菌。此外,这种稳定形态应易于处理,以使消费者能够将其施用于宠物并确定其宠物在摄入所述益生菌。而且,所述益生菌微生物应以可控制的量存在,以使主人知道其宠物正在摄入特定剂量的益生菌。被摄入时,所述益生菌形态应能够在宠物体内存活,直到其达到胃肠道并在胃肠道中活化。
因此,需要一种稳定的、易于处理的、可存活的并且剂量可控的益生菌组合物及其制造方法。
发明概述
为了满足当前的需求并对现有技术加以改进,本发明设想了一种用于给宠物递送益生菌补充剂的商业制品,所述商业制品包括:包括泡罩包装的初级容器;包含益生菌组分的补充剂;其中补充剂被容纳在泡罩包装内。所述商业制品还可包括一种用于容纳初级容器的次级容器。所述次级容器可包括标记。所述标记可包括一种能与补充剂所提供的健康有益效果相关联的颜色。所述泡罩包装可包括外壳。所述外壳可包括:底部表面和主体表面,所述底部表面和主体表面一起限定了用于所述补充剂的内部体积;围绕所述外壳的顶部设置的唇缘;在主体表面和唇缘之间形成的褶边;其中由褶边形成的半径大于由唇缘形成的半径。所述外壳可包括热成型的塑料制品。
此外,还设想了用于向宠物主人传达信息的系统。所述系统可包括:第一产品,其包括第一形状、第一颜色和第一健康有益效果;第二产品,其包括第二形状、第二颜色和第二健康有益效果;其中所述第一产品包括第一益生菌组分;并且其中所述第二产品包括第二益生菌组分。
此外,还设想了一种排列。所述排列可包括:第一包装,该第一包装包括容纳第一初级容器的第一次级容器,其中所述第一初级容器包括第一泡罩包装,所述第一泡罩包装包括第一外壳,所述第一外壳容纳包含第一益生菌组分的第一补充剂;第二包装,该第二包装包括容纳第二初级容器的第二次级容器,其中所述第二初级容器包括第二泡罩包装,所述第二泡罩包装包括第二外壳,所述第二外壳容纳包含第二益生菌组分的第二补充剂;所述第一补充剂可为伴侣动物提供第一健康有益效果,所述第二补充剂可为伴侣动物提供第二健康有益效果。第一健康有益效果和第二健康有益效果可包括相同的或不同的健康有益效果。所述第一次级容器可包括第一标记,所述第二次级容器可包括第二标记,其中第一标记和第二标记包括相同的标记。第一益生菌组分和第二益生菌组分可包括相同的或不同的益生菌组分。
此外,还设想了一种商业制品。所述商业制品可包括:泡罩包装,其包括第一外壳和第二外壳;容纳在所述第一外壳中的第一补充剂,其包含第一益生菌组分;容纳在所述第二外壳中的第二补充剂,其包含第二益生菌组分;其中所述第一补充剂为伴侣动物提供第一健康有益效果,所述第二补充剂为伴侣动物提供第二健康有益效果。第一健康有益效果和第二健康有益效果可包括相同的或不同的健康有益效果。第一益生菌组分和第二益生菌组分可包括相同的或不同的益生菌组分。
此外,还设想了一种商业制品。所述制品可包括:包括外壳的泡罩包装;包括脂肪涂层的宠物食品补充剂;其中所述宠物食品补充剂被容纳在所述外壳内。
此外,还设想了一种商业制品。所述制品可包括:包装;包括外壳的泡罩包装;宠物食品产品;其中所述泡罩包装被容纳在所述包装内;其中所述宠物食品产品被容纳在所述外壳内;其中所述包装上设置有品牌、包括颜色的标记、以及健康有益效果文字标记。
从下文的图示和优选实施方案的描述中,本发明的众多优点和附加的方面将会显而易见。
附图概述
图1是本发明的一个实施方案的工艺流程的示意图。
图2是本发明的一个实施方案的工艺流程的示意图。
图3是本发明的一个实施方案的初级包装的透视图。
图3A是本发明的一个实施方案的初级包装的外壳的截面图。
图4是本发明的一个实施方案的次级包装的透视图。
图5是可用于本发明的实施方案的标记形式的透视图。
图6是可用于本发明的实施方案的标记形式的透视图。
发明详述
为了促进对本发明的原理的理解,在此将引用图片中所示意的实施方案,并将用具体的文字来描述这些实施方案。但应理解,并未因此而有对本发明的范围作出限制之意。如本发明所涉及的领域中的技术人员所通常会想到的,图示装置的此类改变和进一步的变型以及如本文所阐述的本发明的原理的此类进一步的应用被认为属于本发明的范围。
本文引用的是本发明的一些实施方案中所用的包括多种成分的组分的商品名。本文中,本发明的实施方案并无受限于以特定的商品名提及的材料之意。与本文中以商品名提及的那些材料等效的材料(例如以不同的名称或参考号从不同来源得到的那些)可被替代和用于本文的说明中。此外,本文引用的可以是方法或工序中所用各种设备的某些商品名。等效的设备同样可被替代和用于本文的说明中。
定义
本文所用术语“宠物”定义为家畜,包括但不限于家犬、猫、马、母牛、雪貂、兔子、猪等。本发明的示例性实施方案中使用家犬和猫。
本文所用术语“活性益生菌微生物”或类似术语定义为在活性状态的益生菌微生物,本文定义为包括但不限于那些在休眠状态和孢子状态的益生菌。
本文所用术语“补充剂”定义为一种形式的宠物食品,例如片剂、胶囊或类似形式,或者其他形式如饼干、咀嚼物、可食薄膜或其他犒赏食物,其目的是作为日常消耗的宠物食品的添加物,而非用作完整的宠物餐食。
本发明涉及一种作为补充剂的宠物食品组合物、制造这种补充剂的方法以及这种补充剂的包装,其中所述补充剂包含益生菌组分、甜味剂组分以及脂肪组分。
本发明的组合物
本发明涉及可充分稳定的组合物,如此当被哺乳动物摄取时,益生菌微生物在所述组合物中仍处于存活或休眠状态,从而维持所述微生物的活性。所述组合物可包含:(a)益生菌组分;(b)甜味剂组分;以及(c)任选地可可脂组分。
如本文中所发现的,甜味剂组分被发现可作为一种促进所述组合物的加工的助流剂起作用。不使用所述甜味剂组分可带来某些问题,包括起泡和流动不顺。
所述组合物可采取任何口服形式。例如,所述组合物可以是片剂、胶囊、补充剂或类似的形式。其他形式可包括包含所述益生菌和甜味剂组分的粉末以用于与哺乳动物日常消耗的食品联合使用。
在一个实施方案中,所述组合物是一种宠物食品组合物。本文所用术语“宠物食品组合物”是指旨在被宠物摄取的组合物。宠物食品组合物可包括但不限于适用于日常饲养的营养平衡的组合物,以及可为营养平衡的或不平衡的补充剂(例如犒赏食物、可食用薄膜)。像这样的宠物食品组合物或其组分可以是营养平衡的或不平衡的。本文所用术语关于宠物食品组合物或其组分是“营养平衡的”是指根据宠物营养学领域中公认权威人士的建议,所述组合物或组分以适当含量和比例包含除额外所需的水之外的已知维持生命所需的营养物质。
在本领域,宠物食品组合物显然地为例如干燥食品(如至少部分挤压的粗磨食品)和更不易碎的食品(如半干性食品),或它们的混合物。宠物食品组合物还可以是补充剂,例如片剂、胶囊或类似形式,或其他形式如饼干、咀嚼物、可食用薄膜或其他犒赏食物。
所述益生菌组分和甜味剂组分可描述如下:
益生菌组分
所述益生菌组分可包含一种或多种酵母或细菌类的益生菌微生物,这些微生物适合宠物食用并可有效改善宠物胃肠道中的微生物平衡,或者具有其它有益效果,例如减轻或预防宠物疾病或病症。本领域已知的多种益生菌微生物适合在本发明的一些实施方案中使用。例如参见授予Societe Des Produits Nestle的WO 03/075676,公布于2003年9月18日,和授予Nestec的WO 07/126990A2,公布于2007年11月22日。
所述益生菌组分可以任意地属于多个细菌的属。所述细菌的属的非限制性实例包括芽孢杆菌属、拟杆菌属、双岐杆菌属、肠球菌属(如屎肠球菌DSM 10663)、乳酸杆菌属和明串珠菌属、以及它们的组合。属于芽孢杆菌属的那些可形成孢子。在一个实施方案中,益生菌组分不形成孢子。适用于本文的乳酸菌的非限制性实例包括乳酸链球菌、乳脂链球菌、双乙酰乳酸链球菌、嗜热乳酸链球菌、保加利亚乳杆菌、嗜酸乳杆菌(如嗜酸乳杆菌菌株DSM13241)、瑞士乳杆菌、双叉乳杆菌、干酪乳杆菌、乳酸乳杆菌、植物乳杆菌、鼠李糖乳杆菌、德氏乳杆菌、嗜热乳杆菌、发酵乳杆菌(Lactobacillus fermentii)、唾液乳杆菌、罗伊氏乳杆菌、长双歧杆菌、婴儿双歧杆菌、双歧双歧杆菌、动物双岐杆菌、假长双歧杆菌和啤酒片球菌菌株、或者它们的混合物,优选地为唾液乳杆菌、婴儿双歧杆菌或者它们的混合物。
作为非限制性实例,可使用切除自犬科动物并经清洗的胃肠道中分离到的双歧杆菌菌株,如美国专利公布2005/0152884、2005/0158293、2005/0158294和2005/0175598A1,以及WO05060707A2中所公开的。从切除自猫科动物并经清洗的胃肠道中分离到的菌株可为尤其适用的。可使用的猫科动物菌株的非限制性实例公开于美国专利公布2006/0269634和2006/0270020中。
在一个实施方案中,本发明的组合物可具有至少计数为约105菌落形成单位数(CFU)每克组合物,或者至少约106CFU每克组合物,或者至少约108CFU每克组合物的活性益生菌微生物。例如,所述组合物可具有计数为最高约1014CFU每克组合物,最高约1012CFU每克组合物,最高约1010CFU每克组合物,或者最高约109CFU每克组合物的活性益生菌微生物。CFU采用作为欧洲药典方法(European Pharmacopoeial Methods)2003,章节2.6.12的一部分提供的方法测定。有利的是,本文提供的组合物具有至少约三个月,或者至少约六个月,或者从约三个月至约二十四个月,或者从约六个月至约十八个月的储存寿命。本文所用术语“储藏寿命”是指所述组分中约1%或更多,或者约5%或更多,或者约10%或更多,或者约25%或更多,或者约50%或更多,或者约75%或更多的益生菌微生物在暴露于周围环境条件后规定时期内活着并具有活性。
作为进一步的实例,所述组分可包含按所述组分重量计至少约0.001%,或者至少约0.01%,或者至少约0.1%,或者至少约0.5%,或者至少约1%的益生菌组分。作为进一步的实例,所述组分可包含按所述组分重量计约99%或更少,或者约75%或更少,或者约50%或更少,或者约25%或更少,或者约10%或更少,或者约5%或更少的益生菌组分。
甜味剂组分
本文的组合物包含甜味剂组分,其可作为所述组合物的助流剂在加工过程中起作用。不使用所述甜味剂组分可带来某些问题,包括起泡和流动不顺。本文定义的甜味剂组分可包括单糖、二糖、或任何它们的混合物。
在一个实施方案中,本文的组合物包含单糖。本文利用的单糖符合通式CnH2nOn,其中n为等于或大于3的整数。可用的单糖的非限制性实例包括山梨醇、甘露糖醇、赤藓糖、苏阿糖、核糖、阿拉伯糖、木糖、核酮糖、葡萄糖、半乳糖、甘露糖、果糖、山梨糖、以及它们的混合物。在一个实施方案中,所述单糖可包括山梨醇、甘露糖醇、葡萄糖、甘露糖、果糖、或它们的任何混合物。在另一个实施方案中,所述单糖是山梨醇。
在一个实施方案中,本文的组合物包含二糖。本文利用的二糖符合通式CnH2n-2On-1,其中所述二糖含有通过糖苷键连接的2个单糖单元。在该式中,n为等于或大于3的整数。本文可用二糖的非限制性实例包括蔗糖、麦芽糖、乳糖醇、麦芽糖醇、麦芽酮糖、乳糖以及它们的混合物。在另一个实施方案中,所述二糖是蔗糖。
在一个实施方案中使用了甜味剂组分,该实施方案可尤其有利于益生菌组分的稳定性,其中所述甜味剂组分包括熔点为从约80摄氏度至约140摄氏度,或者从约90摄氏度至约120摄氏度的单糖或二糖。非限制性的实例包括单糖,如山梨醇或木糖醇。
作为实例,本文的组合物可包含按组合物重量计至少约0.001%,或至少约0.1%,或至少约1%,或至少约5%,或至少约10%,或至少约20%的甜味剂组分。作为进一步的实例,本文的组合物可包含按组合物重量计约99%或更低,或约95%或更低,或约90%或更低,或约75%或更低,或约50%或更低的甜味剂组分。
有多种甜味剂组分可供使用。由于与本发明的实施方案相关的甜味剂组分不仅包含甜味剂组分而且包含其他组分,它们也可看作是甜味剂的来源。根据本发明的实施方案,甜味剂组分,或者可看作是甜味剂组分的来源的实例,可从位于Chicago,IL的BlommerChocolate Company商购获得,其商品名为Blommer白色kreemy涂层。Blommer白色kreemy涂层包括糖衣的白色涂层,所述涂层由白糖、植物油、脱脂奶粉、卵磷脂、人工色素和调味剂的共混物制成。更具体地讲,所述Blommer白色kreemy涂层包含白糖、部分氢化的棕榈仁油、脱脂奶粉、作为乳化剂添加的大豆卵磷脂、单酸甘油酯、二氧化钛形式的人工色素、和人造调味剂。Blommer白色kreemy涂层在5摄氏度一般为完全结晶的固体,并且在18摄氏度开始结晶。其在23摄氏度开始熔解,并在38摄氏度完全处于液态。除了Blommer之外,白色kreemy涂层还可从其他制造商处获得,并且同样可以使用。
最终的宠物食品组合物可以补充剂的形式存在,其可包含从约8%至约10%的蛋白质,从约25%至约35%的脂肪,从约1%至1.5%的粗纤维,从约1%至3%的水分/水,从约2%至3%的灰分和约5×1010CFU的益生菌组分,以上百分比均以补充剂计。所述补充剂可以多种不同的尺寸和重量存在。
任选组分
本发明的组合物可任选地包含一种或多种其他组分,例如本文中所述的任选组分。
在一个实施方案中,所述组分可包含按所述组合物的重量计以干物质为基础的从约0.1%至约30%的粗蛋白,或从约1%至约20%的粗蛋白。所述粗蛋白材料可包括任何具有按重量计至少约15%的蛋白质含量的材料,其非限制性实例包括植物蛋白如大豆、棉籽和花生,动物蛋白如酪蛋白、白蛋白、鸡肉、牛肉、猪肉、羊肉、火鸡肉、禽肉和肉类组织,以及细菌成分如乳酸杆菌、双歧杆菌、链球菌、肠球菌、芽孢杆菌。可用于本发明的肉类组织的非限制性实例包括新鲜肉类以及干的或精炼肉类,例如鱼粉、禽肉粉、肉粉、骨粉等。其它适用的粗蛋白源包括小麦面筋或玉米面筋,以及提取自微生物来源如酵母的蛋白质。
所述组合物可包含脂肪源。在一个实施方案中,所述组分可包含按所述组分重量计以干物质为基础的从约5.0%至约2.0%的脂肪,或从约10%至约0.5%的脂肪。脂肪源是普遍已知的,如本文所用,将其解释为包括(例如)蜡、脂肪、脂肪酸、和/或类脂。
根据本领域普遍的命名法,蜡、脂肪、脂肪酸或类脂的具体实例可经常是可以互换的;例如,类脂常常也可被称为脂肪。本文的发明人不欲受任何具体命名法的限制,将具体物质分类为蜡、脂肪、脂肪酸、类脂等仅仅是出于方便的需要。
例如,脂肪可包含可可脂组分。本文定义的可可脂组分包含一种或多种可可脂、可可脂填料、可可脂替代物或可可脂代用品。给定的脂肪可被分类成可可脂填料、可可脂替代物或可可脂代用品的其中一种,或有时可被分类成两种或更多种可可脂填料、可可脂替代物或可可脂代用品。当使用时,每一种可可脂填料、可可脂替代物或可可脂代用品可以是在参考种类中的一种具体的脂肪或这些脂肪的任何混合物。
可可脂是本领域通常已知的,通常指来自用于制备巧克力的可可豆的脂肪。可可豆可从可可树(如Theobroma cocoa)的豆荚获得。可可脂可从位于Chicago,IL的BlommerChocolate Company商购获得。可从Blommer购得的可可脂的一个实例包括他们的标准可可脂。这种可可脂可以是初榨可可脂,其来自对经适当烘焙、风选和混合碾磨的巧克力浆进行机械压榨。压榨之后,所述可可脂可通过离心除去任何残余的固体。如此,这种可可脂调味剂可不含任何异味或异常特征。其熔点可以是约30至35摄氏度。此外,所述可可脂的水活度可低于支持微生物的生长所需的水活度水平。
可可脂组分另外地或可供选择地可包含可可脂填料。这些填料也是本领域通常已知的,通常是指其它具有固体脂肪指数(SFI)特征,与可可脂类似的脂肪。可可脂填料可包含含有C16或C18脂肪酸或其组合的脂肪。棕榈油、非洲酪脂树油、雾冰草脂、芒果脂、婆罗双树脂、棉籽油和大豆油,包括其馏分和/或部分氢化形式,是可可脂填料的非限制性实例。
可可脂组分另外地或可供选择地可包含可可脂替代物。这些替代物也将是本领域通常已知的,通常是指其熔融或其它性质,或结构与可可脂相似的脂肪,它们基于非月桂酸型脂肪(例如C16或C18)。这些脂肪包括植物油如棕榈油、棉籽油、大豆油和油菜籽油,包括其馏分和/或部分氢化形式。一个实施例是ASTRALR(部分氢化植物油(大豆油和棉籽油),自Humko Oil Products,Cordova,TN商购获得)。
所述可可脂组分另外地或可供选择地可包含可可脂代用品。这些代用品也将是本领域通常已知的,通常是指其熔融或其它性质,或结构与椰子油相似的硬脂肪,但它们基于月桂酸型脂肪(C12)。这些可可脂代用品可趋于具有比可可脂更高的熔点,使得这些代用品令人感兴趣,因为它赋予组合物抗热性。这些脂肪包括植物油如棕榈仁油和椰子油,包括其馏分和/或部分氢化形式。
在一个实施方案中,所述可可脂组分包含至少一种类脂,所述类脂选自由大豆油、棉籽油、椰子油、油菜籽油、棕榈仁油、前述物质的馏分、以及前述物质的部分氢化形式组成的组。
可供选择地或另外地,脂肪可包含动物来源的脂肪组分。动物来源的脂肪组分包含衍生自动物的脂肪,这一点将是本领域通常已知的。非限制性实例包括牛肉、禽肉、猪肉和羊肉(例如猪油和牛油)。乳制品脂肪也可是实例,包括乳脂、分馏乳脂和牛奶脂肪。
在一个实施方案中,所述脂肪可包含可可脂组分和动物来源脂肪组分的组合,其比例为按重量计约5∶95至约95∶5,或约5∶95至约25∶75,或约5∶95至约50∶50。在本文的另一个实施方案中,所述脂肪包含可可脂组分和动物来源脂肪组分,其比例为按重量计约20∶80至约45∶55,或约25∶75至约40∶60。
可供选择地或另外地,脂肪可包含脂肪酸。示例性的来源包括ω-3或ω-6脂肪酸。
ω-3-脂肪酸优选来源于海洋(鱼类)资源,包括鲱鱼(一种青鱼样的鱼),并且同样地可来源于类似的资源。ω-3-脂肪酸来源的非限制性实例包括二十二碳六烯酸(DHA)或二十碳五烯酸(EPA),例如可自位于Houston,Tex的Omega Protein,Inc.商购获得的OMEGAPURE。本文也考虑到了脂肪酸的所有形式。例如,DHA常常以甘油三酯形式提供。同样地,当提及具体的脂肪酸时(例如“DHA”),这样的脂肪酸不仅包括该脂肪酸的游离形式,而且还包括它的其他形式,例如天然存在的甘油三酯或其他形式。为方便起见利用术语DHA、EPA或其它的具体术语,这将被本领域通常理解为包括这些术语代表物质的所有形式。
本文可利用ω-6-脂肪酸。这是本领域所熟知的,ω-6-脂肪酸是那些当从碳链的ω(末端)碳原子开始计数时,在脂肪酸链的第六和第七个碳原子间具有双键的脂肪酸物质。
其它适用的脂肪酸实例可包括油酸、硬脂酸、棕榈酸和月桂酸、包括它们的合适的盐。更多合适的脂肪酸实例包括其酯或其它衍生物,例如棕榈酸十六酯、乙酸、乳酸或柠檬酸甘油一酯和甘油二酯脂肪酸、棕榈酸异丙酯、肉豆蔻酸异丙酯、以及甘油一酯、甘油二酯和甘油三酯(它们中的一些也可被描述成脂肪)。
所述组合物可包含ω-3-脂肪酸和ω-6-脂肪酸的混合物,常通过利用多种包含这些组分的材料获得。可用于本文的优选组合物可富含一种或多种特异的ω-3-脂肪酸或ω-6-脂肪酸。
可供选择地或另外地,所述组合物可包含蜡。例如,例证性的蜡包括石蜡、蜂蜡(如白色或黄色的)、巴西棕榈蜡、小烛树蜡、微晶蜡、米糠蜡、十六烷基酯蜡和乳化蜡。
作为另外一种选择或除此之外,所述组合物可包含多糖,例如紫胶、甲壳质、脱乙酰壳多糖或海藻酸盐。
本文的组合物可任选地包含碳水化合物源。谷物或谷类如大米、玉米、蜀黍、高粱、大麦、紫花苜蓿、小麦等是说明性的碳水化合物源。这些碳水化合物源及其典型的水平是普遍已知的。
所述组合物可包含例如干乳清或其它乳品副产品组分。
所述组合物可包含可发酵的纤维。可发酵的纤维是本领域所熟知的。可发酵的纤维可以是任何纤维源,存在于动物体内的肠道细菌可使其发酵以产生短链脂肪酸或其它代谢组分。所述可发酵的纤维的非限制性实例包括甜菜渣(来自糖用甜菜)、阿拉伯树胶、塔哈树胶、车前子、米糠、槐豆胶、柑橘渣、果胶、低聚果糖、甘露聚寡糖、大豆纤维、阿拉伯糖基半乳糖、低聚半乳糖、阿拉伯糖基木聚糖、以及它们的混合物。
通常,哺乳动物不能消化可发酵的纤维,但是肠道细菌如双歧杆菌可将其代谢。然而,不是所有的肠道细菌都能代谢可发酵的纤维。具体而言,例如沙门氏菌、大肠杆菌和梭状芽孢杆菌这样的细菌不能将此类纤维处理至任何有意义的程度。这种可应用于可发酵的纤维类的优选消化性能被用于改善宠物小肠内的总体菌群。因为仅仅“好”细菌如乳酸菌和双歧杆菌能以可发酵的纤维为食,有害细菌如沙门氏菌、大肠杆菌和梭状芽孢杆菌的数量由于食物源的减少会下降。因此,通过向有益菌种提供优选的食物源,用可发酵的纤维的补充食物能增加“好”肠道细菌并同时减少“坏”细菌的量。
甜菜渣和低聚果糖,尤其是短链果寡糖,是可用于本文的尤其优选的可发酵的纤维。作为一个实例,果寡糖是天然存在的化合物,它可见于多种水果或蔬菜中,包括香蕉、大麦、大蒜、蜂蜜、洋葱、裸麦、红糖、番茄、芦笋、朝鲜蓟、小麦、雪莲果或菊苣。果寡糖可以例如菊苣根、长链果寡糖(如菊糖)或短链果寡糖的形式提供。本文尤其有用的是包含1-蔗果三糖(简称GF2),蔗果四糖(GF3),和1F-β-呋喃果糖基蔗果四糖(GF4)中至少一种的果寡糖。虽然果寡糖能从那些本文提到的植物中提取,它们也能通过将一个、两个或三个果糖单位加到一个蔗糖分子上而被人工形成,由B-(2-1)-糖苷连接果糖单位到蔗糖的果糖单位。作为一个实例,果寡糖以商品名NUTRAFLORA由Golden Technologies Company,Incorporated市售(它是短链低聚果糖,包含1-蔗果三糖、蔗果四糖、和1F-β-呋喃果糖基蔗果四糖)。作为另一个实例,短链低聚果糖和菊粉的混合物可以是PREBIO1或市售的RAFTILOSE和RAFTILINE的混合物。
低聚果糖可以是短链果寡糖,这是本领域的普通技术人员所熟知的。本文尤其有用的是包含1-蔗果三糖(简称GF2),蔗果四糖(GF3),和1F-β-呋喃果糖基蔗果四糖(GF4)的短链果寡糖。在一个优选的实施方案中,短链果寡糖包含按短链果寡糖重量计约25%至约45%的1-蔗果三糖,约25%至约45%的蔗果四糖和约1%至约20%的1F-β-呋喃果糖基蔗果四糖,可供选择地按短链果寡糖重量计约30%至约40%的1-蔗果三糖,约50%至约60%的蔗果四糖,和约5%至约15%的1F-β-呋喃果糖基蔗果四糖。作为一个实例,短链果寡糖以商品名NUTRAFLORA由Golden Technologies Company,Incorporated市售(它是短链低聚果糖,包含按短链果寡糖重量计约35%的1-蔗果三糖、55%的蔗果四糖、和10%的1F-β-呋喃果糖基蔗果四糖)。
在一个实施方案中,可发酵的纤维可显示某些有机物的转化百分比。在此任选的实施方案中,可发酵的纤维当被粪便细菌在体外进行超过24小时酵解时,其有机物转化率(OMD)可达到约15%至约60%。也就是说,该有机物原始总量的约15%至约50%能被粪便细菌所酵解和转化。所述纤维的有机物转化率可供选择地为约20%至约50%,或约30%至约40%。
因此,体外OMD百分比可计算如下:(1--((OM残余-OM空白)/初始OM))×100,其中OM残余为发酵24小时后回收到的有机质,OM空白为从相应的空白管(即包含介质和经稀释的粪便,但不含底物的管)中回收到的有机质,初始OM为发酵前放入管中的有机质。所述规程的附加细节参见Sunvold等人,J.Anim.Sci.,Vol.73,pp.1099-1109(1995)。
在本文的一个实施方案中,组合物可包含按组合物重量计至少约0.25%的总发酵性纤维。“总发酵性纤维”是指通过累加组合物中存在的每个发酵性纤维的量来测定的参考含量。例如,其中组合物包含按组合物重量计1%的果寡糖和0.5%的甜菜渣,无其它的发酵性纤维。所述组合物包含按组合物重量计1.5%的总发酵性纤维。可供选择地,本组合物可包含按宠物食物组合物重量计至少约0.5%的总发酵性纤维,至少约1%的总发酵性纤维,至少约2%的总发酵性纤维,或约1%至约20%的总发酵性纤维,或约1%至约10%的总发酵性纤维,或约2%至约10%的总发酵性纤维,或约3%至约8%的总发酵性纤维。
在本文的实施方案中,宠物食物组合物可包含营养食品。本文所用的营养食品是指提供健康有益效果的食品(作为强化食品或食物补充剂)。
本发明组合物中能存在的其它物质包括矿物质,例如但不限于碳酸钙、钙、硼、硒、氯化钙、氯化物、延胡索酸亚铁、乙酸锌、氯化胆碱、铬、葡萄糖酸亚铁、硫酸锌、甲基比啶铬、钴、氧化镁、葡萄糖酸锌、磷酸二钙、铜、硫酸镁、硫酸亚铁、碘、碳酸镁、磷酸二氢钠、铁、吡啶甲酸铬、氯化钾、镁、柠檬酸钙、柠檬酸钾、锰、乳酸钙、山梨酸钾、磷、葡萄糖酸钙、硫酸氢钠、钾、氯化铬、六偏磷酸钠、钠、烟酸铬、磷酸三钙、锌、柠檬酸铬、包含任何这些矿物质的酵母等。
在本发明的实施方案的组合物中还可存在更多的附加材料。实例包括活性物和非活性物。非限制性实例包括:蛋白质成分,其非限制性实例包括鸡肉粉、鸡肉、鸡肉副产物粉、羊肉、羊肉粉、火鸡肉、火鸡肉粉、牛肉、牛肉副产物、内脏、鱼粉、肠、袋鼠肉、白鱼肉、鹿肉、大豆粉、大豆分离蛋白、大豆浓缩蛋白、玉米麸粉、玉米浓缩蛋白、以及蒸馏干燥的谷物溶解物;淀粉成分,其非限制性实例包括谷类食物、谷物、玉米、小麦、大米、燕麦、粗磨玉米粉、高粱、高粱谷粒、蜀黍、麦麸、燕麦麸、苋菜、硬质小麦和粗面粉;纤维成分,其非限制性实例包括果寡糖(FOS)、甜菜浆、甘露寡糖(MOS)、燕麦纤维、柑橘渣、羧甲基纤维素(CMC)、瓜尔胶、阿拉伯胶、苹果渣、柑橘纤维、纤维提取物、纤维衍生物、干甜菜纤维(除糖的)、纤维素、α-纤维素、半乳寡糖、木寡糖,以及来自淀粉、菊粉、车前草、果胶、柑橘果胶、瓜尔胶、黄原胶、海藻酸盐、阿拉伯胶、赛伊尔相思树胶、β-葡聚糖、甲壳质、木质素、纤维素、非淀粉多糖、卡拉胶、低筋淀粉、大豆低聚糖、海藻糖、棉子糖、水苏糖、乳果糖、葡聚糖、低聚葡糖、龙胆寡糖、果胶寡糖和半纤维素的寡糖衍生物;其他脂肪成分,其非限制性实例包括家禽脂肪、鸡肉脂肪、火鸡肉脂肪、猪肉脂肪、猪油、牛油、牛肉脂肪、植物油、玉米油、大豆油、棉籽油、棕榈油、棕榈仁油、亚麻籽油、卡诺拉油、油菜籽油、鱼油、鲱鱼油、鳀鱼油和奥利斯特拉(olestra);矿物质成分,其非限制性实例包括亚硒酸钠、磷酸二氢钠、碳酸钙、氯化钾、硫酸亚铁、氧化锌、硫酸锰、硫酸铜、一氧化锰、碘化钾和碳酸钴;维生素成分,其非限制性实例包括氯化胆碱、维生素E补充剂、抗坏血酸、维生素A醋酸酯、泛酸钙、泛酸、生物素、硝酸硫胺(维生素B1源)、维生素B12补充剂、烟酸、核黄素补充剂(维生素B2源)、肌醇、盐酸吡哆醇(维生素B6源)、维生素D3补充剂、叶酸、维生素C以及抗坏血酸;多酚,其非限制性实例包括茶叶提取物、迷迭香提取物、迷迭香酸、咖啡提取物、咖啡酸、姜黄提取物、蓝莓提取物、葡萄提取物、葡萄籽提取物、大豆提取物;氨基酸,其非限制实例包括l-色氨酸、牛磺酸、组氨酸、肌肽、丙氨酸、半胱氨酸、精氨酸、甲硫氨酸、色氨酸、赖氨酸、天冬酰胺、天冬氨酸、苯丙氨酸、缬氨酸、苏氨酸、异亮氨酸、组氨酸、亮氨酸、甘氨酸、谷氨酰胺、酪氨酸、同型半胱氨酸、鸟氨酸、瓜氨酸、谷氨酸、脯氨酸和丝氨酸;类胡萝卜素,其非限制性实例包括叶黄素、虾青素、玉米黄质、红木素、番茄红素和β-胡萝卜素;抗氧化剂,其非限制性实例包括生育酚(维生素E)、维生素C、维生素A、植物来源的材料、类胡萝卜素(如上所述)、硒和CoQ10(辅酶Q10);脂肪酸,其非限制性实例包括花生四烯酸、α-亚油酸、γ亚麻酸、亚油酸、二十碳五烯酸(EPA)、二十二碳六烯酸(DHA)、以及作为EPA和/或DHA源的鱼油;葡萄糖模拟物,其非限制性实例包括葡萄糖抗代谢物、脱水糖、甘露庚酮糖和包含甘露庚酮糖的鳄梨提取物,其中所述葡萄糖抗代谢物包括2-脱氧-D-葡萄糖、5-硫代-D-葡萄糖、3-O-甲基葡萄糖,其中所述脱水糖包括1,5-脱水-D-山梨醇、2,5-脱水-D-山梨醇和2,5-脱水-D-甘露醇;其他成分,其非限制性实例包括牛肉肉汤、酿酒干酵母、蛋、蛋产品、亚麻粉、DL蛋氨酸、氨基酸、亮氨酸、赖氨酸、精氨酸、半胱氨酸、胱氨酸、天冬氨酸、多磷酸盐如六偏磷酸钠(SHMP)、焦磷酸钠、三聚磷酸钠、氯化锌、葡萄糖酸铜、氯化亚锡、氟化亚锡、氟化钠、三氯生、盐酸葡萄糖胺、硫酸软骨素、绿唇贻贝、蓝唇贻贝、甲基磺酰甲烷(MSM)、硼、硼酸、植物雌激素、植物雄激素、染料木素、黄豆苷原、L-肉毒碱、吡啶甲酸铬、三吡啶甲酸铬、烟酸铬、酸/碱调整剂、柠檬酸钾、氯化钾、碳酸钙、氯化钙、硫酸氢钠;桉树、薰衣草、胡椒薄荷、增塑剂、着色剂、调味剂、甜味剂、缓冲剂、增滑剂、载体、pH调节剂、天然成分、稳定剂、生物添加剂如酶(包括蛋白酶和脂肪酶)、化学添加剂、冷却剂、螯合剂、变性剂、药物收敛剂、乳化剂、外用止痛剂、香料化合物、湿润剂、不透明剂(例如氧化锌和二氧化钛)、抗起泡剂(例如硅胶)、防腐剂(例如丁基羟基甲苯(BHT)和丁基羟基甲氧苯(BHA)、没食子酸丙酯、苯扎氯铵、EDTA、苯甲醇、山梨酸钾、对羟基苯甲酸酯类、以及它们的混合物)、还原剂、溶剂、助水溶剂、增溶剂、悬浮剂(非表面活性剂)、溶剂、粘度增加剂(水性或非水性的)、螯合剂和角质剥脱剂。
本发明的实施方案的组合物还可包含益生菌组分。“益生元”包括宠物的肠菌落发酵产生的物质或化合物,因此促进宠物胃肠道中的乳酸菌的生长或发展并抑制病原菌的生长。发酵的结果可以是脂肪酸的释放,尤其是结肠中的短链脂肪酸。释放可具有降低结肠中pH值的效果。适当的益生元的非限制性实例包括低聚糖,例如菊粉及其通常被称为果寡糖的水解产物、半乳寡糖、木寡糖或淀粉的寡糖衍生物。益生元可以任何合适的形式提供。例如,益生元可以包含纤维的植物材料形式提供。合适的植物材料包括芦笋、朝鲜蓟、洋葱、小麦或菊苣、或这些植物材料的渣滓。可供选择地,益生元纤维可以菊粉提取物形式提供,例如菊苣的提取物是合适的。合适的菊粉提取物可获取自Orafti SA of Tirlemont 3300,Belgium,商标“Raftiline”。例如,菊粉可以Raftiline(g)ST形式提供,这是精炼白色粉末,包含按重量计约90%至约94%的菊粉,最多约4%的葡萄糖和果糖和约4%至9%的蔗糖。可供选择地,纤维可以是低聚果糖的形式,例如获取自Orafti SA of Tirlemont 3300,Belgium,商标“Raftilose”的低聚果糖。例如,菊粉可以Raftilose(g)P95形式提供。另外,低聚果糖可通过水解菊粉、酶法或使用微生物获得。
在一个实施方案中,宠物食品补充剂包含如上文所述的益生菌组分、如上文所述的可可脂组分和如上文所述的甜味剂组分。所述宠物食品补充剂可包含约0.001%至约10%的益生菌组分、约2%至约4%的可可脂组分和约0%至约100%的甜味剂组分,对于所述每种组分,均包括所述百分比之间的任意范围。具体范围的非限制性实例包括约8%至约10%的益生菌组分、约2%至约4%的可可脂组分和约85%至约95%的甜味剂组分。
加工
本文所述的组合物可包含任意多种对制造宠物食品常用的加工条件敏感的组分。例如,可以保持这些敏感组分的完整性(或者完全地或者部分地)。敏感组分的非限制性实例包括这样的组分:当组分被包含在标准的商业宠物食品中时,在标准挤出过程中显示具有超过约10%的损失(按重量计),或者超过约20%的损失,或者超过约50%的损失。挤出方法是本领域所熟知的。敏感组分的包括的或可供选择的实施例包括抗氧化剂如维生素,包括但不限于维生素A(包括其衍生形式,如β-胡萝卜素和类胡萝卜素)、维生素C(包括其衍生形式)、维生素E(包括其衍生形式)、维生素D(包括其衍生形式)、酚、类胡萝卜素、生物碱、氧杂蒽酮、多酚、β-胡萝卜素、有机含硫酸、酸性黄、莰非素、虾青素、γ-谷氧酰胱氨酸、儿茶素、紫檀芪、角黄素、半胱氨酸、鞣花酸、五羟黄酮、金枪鱼叶黄素、异硫氰酸酯、黄芩甙、生育酚、杨梅酮、玉米黄质、类黄酮、白藜芦醇、花青素、胭脂树橙、异黄酮、长春西汀、黄酮醇、叶黄素、辅酶-Q10、原花青素、番茄红素、硫辛酸等。
用于制造根据上文公开的组合物的宠物食品补充剂的方法的一个实施方案描述于下文中,并且一般参见图1。图1为工艺流程10的一个示意图,其一般地显示了制造宠物食品补充剂的方法的一个实施方案。在该实施方案中,所述补充剂的组成可包含可可脂、白色涂层形式的甜味剂(其实施方案之一已描述于上文中)和益生菌微生物形式的益生菌组分。首先,可将可可脂加热至约130华氏度并使其在可可脂槽101中熔化,所述可可脂槽101可以是通过夹套102与换热器103相连的槽。加热可在生产最终的宠物食品补充剂之前八小时甚至更长的时间进行。在生产之前八小时或更长的时间进行加热有助于从可可脂中除去残余的水。夹套102可具有用于加热槽101中的可可脂产品的循环的热水。加热和熔化之后,可将热可可脂通过换热器103以使可可脂冷却至约110华氏度。从130华氏度冷却至110华氏度有助于降低可可脂的热量对益生菌微生物的灭活作用。加热至130华氏度可有助于除去可可脂中的水分,而水分的除去则可防止益生菌微生物的过早活化。然而,130华氏度对益生菌微生物过于高了,因为这一温度可使益生菌微生物失活。在110华氏度,益生菌微生物的失活一般不会发生,并且这一温度允许可流动并且可混溶的可可脂组分。可可脂可用正位移泵104通过流量计105从换热器103转运至混合槽108。流量计105有助于控制用正位移泵104转运的可可脂的适当的量。螺杆泵106可通过流量计107与混合槽108相连。螺杆泵106将益生菌微生物加入至混合槽108。流量计107有助于控制进入混合槽108的益生菌微生物的适当的量。益生菌微生物可存储于罐子、瓶子或其他容器中,并被加入一个可与螺杆泵106相连的料斗中。混合槽108可以是带夹套的刮研表面混合槽。该槽可通过夹套109用热水维持在大约105华氏度。在105华氏度而非110华氏度,益生菌微生物可储存更长的时间。因此,在这一点上于105华氏度操作有助于防止或抑制益生菌微生物的任何过早的失活。混合槽108可以是混合益生菌微生物和经加热和熔化的可可脂的位置。
可可脂和益生菌微生物混合之后,可将混合物通过泵110从混合槽108转运至混合槽117。泵110可以是莫依诺泵。莫依诺泵可允许对所述混合物非常温和的转运,并因此能防止或抑制所述混合物受到剪切、损坏或者其他物理应力作用,这种泵可被用于从混合槽108转运所述可可脂和益生菌微生物的混合物。静态搅拌器111和三通阀112共同作用,从而促进所述可可脂和益生菌微生物的混合物取决于三通阀112位置的彻底混合。三通阀112可将所述混合物或者导回混合槽108,或者导入混合槽117。可可脂和益生菌微生物混合物的凝结是应当避免的,因此静态搅拌器111和三通阀112共同作用,以减少并期望能消除所述可可脂和益生菌微生物混合物的凝结。
一旦所述混合物已大体上(若非完全地)均质化并且益生菌微生物已是饱和的或者被可可脂完全包被,即可将三通阀112变更至将所述混合物从混合槽108导流至混合槽117的位置。然而,此时混合槽117可以已经包含适当量的白色涂层或甜味剂组分,并且在一个实施方案中,直到该条件满足才开始将可可脂和益生菌微生物混合物从混合槽108向混合槽117转运。所述甜味剂或白色涂层可从白色涂层槽113引出。白色涂层槽113可具有夹套114,该夹套114可有助于将槽维持在105华氏度。在将白色涂层与所述可可脂和益生菌微生物混合物混合之前,可将其在105华氏度保温约24小时或更长时间。白色涂层槽113可存储白色涂层并保持其处于熔化状态以与所述可可脂和益生菌微生物混合物混合。白色涂层可用正位移泵115从白色涂层槽113引出,所述正位移泵115可受流量计116控制以保证正确的给料量。已发现,为了稠度目的和得到更好的终产品,在混合槽117中将所述可可脂和益生菌微生物混合物与白色涂层混合可以是有利的。混合槽117可具有夹套118,并且可以是刮研表面混合槽。混合槽117可通过流经夹套118的热水维持在约100至105华氏度。
可包括一个莫依诺泵119,并可用其使所述可可脂和益生菌微生物混合物与白色涂层从混合槽117循环流出以制得合并的混合物。静态搅拌器120可用于促进所述可可脂和益生菌微生物混合物与白色涂层的彻底混合,并可取决于三通阀121的位置。
一旦所述合并的混合物完全地或充分地均质化,即可将三通阀121转至使合并的混合物可通过莫依诺泵119从混合槽117转运至其他设备的位置,其中所述其他设备可被用于使所述合并的混合物成形为补充剂形态。
若需要时,可通过用正位移泵从混合槽122将着色剂进料至混合槽117,其中所述正位移泵可受流量计控制。可使用纯天然着色剂。着色剂的一个非限制性实例是CSL 37542Brown Dispersion OB,可购自位于St.Louis,MO的Sensient Colors。其还可以包括焦糖和红辣椒粉。然而,应当了解的是,任何天然或非天然的脂溶性着色剂均可使用。作为非限制性实例,本文的组合物可包含按所述组合物的重量计约0.1%、约0.2%、约0.3%、约0.4%、或约0%至约1%的着色剂。
应当理解,投影在图1中的受控房间125可控制螺杆泵106、流量计107、混合槽108、泵110、搅拌器111和三通阀112的温度和相对湿度。这种控制可通过在受控的房间或小室内布置所有这些装置来实现。对温度和相对湿度的控制可有助于防止所述益生菌微生物的过早活化。在至少一个实施方案中,所述受控房间125可处于约100华氏度的温度和约10%或更低的相对湿度。一旦益生菌微生物被可可脂包被,所述益生菌微生物过早活化的风险即可通过使用受控房间而显著地降低。所述受控房间125还可防止在益生菌组分上形成凝结。
益生菌微生物在可可脂中以及与白色涂层的均质化混合可以是一个实施方案。在某些情况下,益生菌微生物和可可脂在白色涂层中籍以形成所述合并的混合物的适当分配方面会出现问题。这些问题中至少一种是益生菌微生物未能在合并的混合物中以相对均一化的方式分配。如上文所述,合并的混合物是将益生菌微生物和可可脂的混合物与白色涂层合并所得。当使用数量更多的益生菌微生物时可能会出现这种问题。具体而言,该问题可能在益生菌微生物水平为例如1010CFU时出现。解决这一与益生菌微生物在白色涂层混合物中以均一化方式适当地分配相关的问题的一条途径可以是建立一种用于将白色涂层与益生菌微生物和可可脂混合物混合的两阶段方法。图2为可使用的混合方法20的一个实施方案的示意图。在该实施方案中,所述补充剂的组成可包含可可脂、白色涂层形式的甜味剂(其实施方案之一已描述于上文中,如可购自Blommer)和益生菌微生物形式的益生菌组分。如前,首先可将可可脂加热至约130华氏度并使其在可可脂槽201中熔化。加热可在生产最终的宠物食品补充剂之前八小时甚至更长的时间进行。在生产之前八小时或更长的时间进行加热有助于从可可脂中除去残余的水。加热和熔化之后,可将热可可脂转运并冷却至约110华氏度、或者105华氏度甚至更低。从130华氏度冷却至110或105华氏度有助于降低可可脂的热量对益生菌微生物的灭活作用。可可脂可被转运至混合槽203。此时,可将适当量的益生菌微生物从槽202进料至混合槽203以与可可脂混合。所述益生菌微生物的颗粒大小是可变的。其范围可以从灰尘大小到直径最多2或3mm的颗粒。益生菌微生物可来源于发酵培养过程,其中初始微生物被加入至基于液体(水)的环境中的富含营养物质的生长培养基。当细菌混合物已经过对数期(细菌快速生长期)的生长后,通过喷雾干燥方法将其干燥。然后可将其储存于-4摄氏度或更低。所述混合槽203可维持在约105华氏度。如此,混合槽203可以是混合益生菌微生物和经加热和熔化的可可脂的位置。
此时,可将可可脂和益生菌微生物的混合物与白色涂层合并以帮助所述益生菌混合物的适当分配。这样的合并可在混合槽203中发生。同样地,应当避免可可脂和微生物混合物的凝结,尤其是在加入白色涂层之前。因此,益生菌微生物和可可脂的混合可进行约五分钟,直到获得顺滑的或者大体顺滑的混合物。一旦未凝结或大体上未凝结的益生菌微生物和可可脂的混合物已大体(若非完全地)均质化,并且益生菌微生物已被饱和或完全地被可可脂包被,即可向所述混合物中加入第一份白色涂层加料。第一份白色涂层加料可包括最终将加入至完整混合物中的白色涂层总量的仅仅一部分。同样地,所述第一份加料可帮助益生菌微生物在最终的合并混合物中的适当分配。在一个实施方案中,白色涂层总量的仅约30%在第一份加料中被加入至益生菌微生物和可可脂的混合物。如前,白色涂层可从白色涂层槽204中引出。白色涂层可在白色涂层槽204中维持于约105华氏度,并可在将其与可可脂和益生菌微生物混合物混合之前将其在此温度保持约24小时或更长时间。与白色涂层的所述第一份加料的混合可在混合槽203中发生。同样如前,应当理解,投影在图2中的一个受控房间205至少可控制混合槽203中的温度和相对湿度。控制可可通过在受控的房间或小室内布置所有这些装置来实现。对温度和相对湿度的控制可有助于防止所述益生菌微生物的过早活化。在至少一个实施方案中,所述受控房间125可处于约100华氏度的温度和约10%或更低的相对湿度。一旦益生菌微生物被可可脂包被,所述益生菌微生物过早活化的风险即可通过使用受控房间显著地降低。
将白色涂层的第一份加料加入至混合槽203,并将益生菌微生物、可可脂和白色涂层的合并的混合物混合之后,即可将第二份的白色涂层与所述合并的混合物混合。这样的混合可在混合槽206中发生。然而,此时混合槽206可已经包含其余的白色涂层,以便将可可脂、益生菌微生物和白色涂层的第一份加料加入至业已包含白色涂层的混合槽206。在一个实施方案中,其中如上所述,白色涂层的约30%被用作第一份加料,可使用剩余的约70%。可在加入可可脂、益生菌微生物和白色涂层第一份加料的混合物之前,将白色涂层从白色涂层槽204引入到混合槽206中。同样地,白色涂层槽204可被维持在约105华氏度。白色涂层在混合之前可在约105华氏度下保持约24小时或更长时间。白色涂层槽204可存储白色涂层并保持其处于熔化状态以用于混合。已发现,为了稠度目的和得到更好的最终产品,将所述可可脂、益生菌微生物和白色涂层的第一份加料的混合物与混合槽206中的白色涂层进行混合可以是有利的。混合槽206可被维持在约100至105华氏度。可包括泵,并可用该泵使所述可可脂、益生菌微生物和白色涂层的第一份加料的混合物与白色涂层从混合槽206循环流出以制得合并的混合物。如上文所述,可将所述合并的混合物转运至混合槽207并与着色剂混合,所述着色剂可从槽208加入到混合物中。为了确保所有组分的充分混合,一个实施方案可包括将所述组分混合至少约20分钟以形成均质化的混合物。此时,所述混合物可具有这样的熔解性质:其在0摄氏度为完全结晶的固体,在18摄氏度开始结晶,在25摄氏度开始熔解,并且在39摄氏度完全处于液态。
一旦可可脂、益生菌微生物、白色涂层以及着色剂(若有)形成充分均质化的混合物,即可将所述合并的混合物送至进一步的加工设备以制成期望形式的宠物食品补充剂。在一个实施方案中,作为总的方法的一部分,所述混合物可被置于泡罩包装盘内。在该实施方案中,所述泡罩包装盘包括任意数量的热成型的泡罩外壳,所述外壳可起作用并可作为所述混合物的模具。所述泡罩包装盘和外壳如下文中所详述可包括任意数值的形状、大小和配置,以在完成所述宠物食品补充剂的制造过程方面和在将所述宠物食品补充剂向消费者的呈递中起到任意数量的作用。可将所述混合物置于用作混合物模具的热成型的泡罩外壳中,如上文所述。将所述混合物置于泡罩外壳时的温度可以是约100华氏度。然后可使所述泡罩包装、外壳以及置于的混合物经过一个使所述混合物在外壳内硬化的冷却过程。例如,所述冷却过程可通过一个冷却通道进行,并且可在约60华氏度进行约七至十二分钟。当然,冷却也可以其他的温度和时间完成,并且这样的温度和时间是互相依赖的。例如,冷却可在约50华氏度、甚至低于50华氏度的温度下用约五至十分钟完成。冷却过程中,所述混合物将在所述外壳模具中硬化并结晶,从而形成固态的补充剂。若所述外壳模板具有特定的形状,则所述混合物可硬化为该种形状。这样的形状的非限制性实例包括圆形、椭圆形、矩形、正方形、三角形、梯形、八边形、骨头形、心形和牛排形,并且在下文中对它们有进一步的详细描述。冷却后,可用封闭物,例如能被消费者用公称力撕裂的封闭箔,将所述外壳密封。用箔对所述外壳的密封可在适当的温度和保压时间下完成,所述温度和保压时间基于所述箔和泡罩包装所使用的材料类型。至此,已制成一种泡罩外壳内填充了宠物食品补充剂的泡罩包装。一旦被密封,所述泡罩包装即可被置于一个次级容器或包装内,该次级容器或包装的配置详述于下文中。
所述加工方法通过所述补充剂允许高度一致和可控的定量给料。通过将多种组分充分地均质化混合,可在单独一份的补充剂中提供可控量的益生菌组分,并且得到一致地、可靠地并且可信赖地在一份补充剂中提供一定剂量的益生菌组分的最终产品。
制备宠物食品组合物的另一适当的方法可以是至少部分地挤出,也可使用烘焙和其他适当的方法。干燥的宠物食品当被挤出时通常以粗磨食物形式提供。EP 0,850,569描述了此方法。
本发明的实施方案的包装和补充剂可包含在任意的多种条件下使用和/或用于实现多种健康有益效果的益生菌组分。本发明的组合物可用于将一种或多种有益效果通过口服呈递至优选为宠物的动物。此有益效果通常保持并改善动物的总体健康。动物健康和生理的非限制性因素有益于在治疗学上减轻症状,或者预防疾病,或者改善整体健康,包括免疫系统治疗、肠胃系统治疗、皮肤或毛皮治疗、压力治疗、以及它们的组合。非限制性实例包括炎性失调、免疫缺陷、炎性肠疾病、过敏性肠综合症、癌(尤其是那些肠胃和免疫系统)、外耳炎、腹泻疾病、抗生素相关的腹泻、阑尾炎、自体免疫失调、多发性硬化、阿尔茨海默病、淀粉样变性、类风湿性关节炎、关节炎、关节活动、髋关节发育不良、糖尿病、胰岛素拮抗、细菌感染、病毒感染、真菌感染、牙周病、泌尿生殖疾病、自发性膀胱炎、间质性膀胱炎、外科手术相关的损伤、外科手术诱导的转移性疾病、败血病、体重减退、体重增加、脂肪组织过度积聚、厌食、发烧控制、恶病质、伤口康复、溃疡、肠壁感染、过敏、哮喘、呼吸失调、循环失调、冠心病、贫血、血液凝结系统失调、肾病、中枢神经系统失调、肝病、缺血、营养失调、治疗或预防与下丘脑-垂体-肾上腺(HPA)轴相关的失调、骨质疏松、内分泌失调、和表皮失调。优选胃肠道的治疗,包括治疗或预防腹泻;免疫系统调节,优选治疗或预防自身免疫疾病和炎症,维持或改善皮肤和/或皮毛系统健康,优选治疗或预防皮肤的特应性疾病,治疗或预防与下丘脑-垂体-肾上腺(HPA)轴相关的失调,改善或减少衰老的效果,包括精神意识和活性水平;和在感染期间和在感染之后阻止体重减退。
通过本发明的实施方案向犬科动物提供的健康有益效果的其他实例公开于美国专利公布2005/0152884、2005/0158293、2005/0158294和20050175598A1,以及WO05060707A2中。通过本发明的实施方案向猫科动物提供的健康有益效果的其他实例公开于美国专利公布2006/0269634、2006/0270020和20050175598A1,以及WO05060707A2中。此外,本发明的方法公开于所述公布中。
本发明的实施方案包括用于储存的包装、装运、以及为销售本发明实施方案的组合物,包括如本文所述的补充剂,所作的展示的包装。本发明实施方案的组合物可被包装并密封在不会从所述组合物吸收脂肪的包装系统内。此外,所述益生菌组分可具有热敏感化的性质。这些性质可导致要求具有冷藏,例如在低于约75华氏度的温度,装运能力的包装系统。这些因素对于决定在本发明的组合物的包装中使用的组分的类型可能是重要的。
关于本发明的实施方案的包装方面,可使用下列定义。
本文所用术语“传达”是指一种包装或容器向消费者传达关于所述包装或容器内的一种产品(例如补充剂)的信息。在一个实施例中,关于所述产品的信息可通过文本或非文本的标记向消费者传达。
本文所用术语“直观传达”是指一种包装或容器和/或产品(例如补充剂),其自身包括文本或非文本的标记并通过该标记传达被消费者理解的信息。
本文所用术语“标记”是指可被包括在容器或产品(例如补充剂)上的,关于某物的性质(例如卫生纸产品的强度性质)的标识符和/或指示器和/或提示和/或建议。
本文所用术语“文本标记”是指文本的标记,例如向消费者传达信息的单词和/或短语。文本标记可用于将与补充剂相关联的健康有益效果告知消费者。例如,如果补充剂提供了关节和运动性方面的健康有益效果,可在初级容器、次级容器、所述补充剂自身、或该实施方案的任何其他部分上的任意位置包括用于告知消费者已提供了关节和运动性方面健康有益效果的文本。这样的文本的非限制性实例可以是写在次级容器上并且能被消费者看见的“关节活动性”字样。传达健康有益效果的任何其他类型或形式的文本标记均在预期范围内。
本文所用术语“品牌”是指单一来源的标识符,或者说,品牌标识了排他性地来自单独一个商业来源(即公司)的产品和/或服务。品牌的一个实例是IamsTM,品牌是文本标记的非限制性实例。本发明的补充剂可在一个共同的品牌(即相同品牌,例如IamsTM)下进行销售和/或包装。
本文所用术语“非文本标记”是指通过消费者的感觉向其传达信息的非文本的标记。在一个实施例中,非文本标记可通过视觉向消费者传达甚至直观传达信息(视觉标记)。
非文本标记的非限制性实例包括颜色、纹理、花样,例如压花或凹图花样和/或压花或凹图花样图片、字符表征、动作表征、以及它们的组合。
本文所用术语“颜色”是指人眼分辨不同波长或频率的光的能力所造成的视觉效果。物体的外观颜色取决于它反射的光的波长。
一般来讲,本发明的实施方案的宠物食品补充剂的包装可包括初级容器,所述初级容器具有至少一个外壳,所述外壳包含至少一个剂量单位或补充剂,并且所述剂量单位或补充剂包含益生菌补充剂。所述初级容器可以是泡罩包装,如上文所提及,泡罩卡或泡罩片是为本领域所理解并通常使用的。基于所包含的补充剂的数量、尺寸和类型,所述初级容器可具有所需的不同形状和尺寸并且可具有方便携带的尺寸。此类形状的非限制性实例包括圆形、椭圆形、矩形、正方形、三角形、梯形、六边形、八边形、爪印形、以及它们的组合。所述形状可包括其他标记,例如商标、品牌、商业外观特征等。例如,可使用爪印形状,如图3所示。爪印形状可以是压花的或凹陷图案的。所述初级容器还可被成形为具有使所述初级容器的一个或多个部分可分离的部件,即一个或多个包括外壳的部分。如本领域的技术人员所会理解的,此类设计的非限制性实例包括穿孔、斫刻以及它们的组合。
如包装领域的技术人员所会理解的,泡罩包装可包括一个或多个泡罩层和一个可破裂层,它们的组合包裹着一种或多种补充剂以包括包装的结构和制造。如此,所述泡罩层可以为任意适当尺寸、形状或形态的一种或多种补充剂提供任意适当尺寸和/或形状的外壳。外壳可以是任意形状的,此类形状的非限制性实例包括圆形、椭圆形、矩形、正方形、三角形、梯形、六边形、八边形、骨头型、牛排形、鸡腿形、爪印形、心形、消防栓形、以及它们的组合。当然,所述补充剂同样可采用这些形状,并且至少当所述外壳作为补充剂的模具时如此成形。所述形状可包括其他标记,例如商标、品牌、商业外观特征等。例如,可使用爪印形状,如图3所示。爪印形状可以是压花的或凹陷图案的。所述可破裂层允许补充剂从泡罩包装中移出。所述可破裂层可被成形为在泡罩层的整体或其部分的外面。所述可破裂层可通过如本领域中所常见的那样,利用常规的热成形方法应用热和压力,或者通过粘合剂固定到所述泡罩层上。此类泡罩包装还可包括一个背衬层,所述背衬层可设置在可破裂层之上或其外面以用于防止非预期的破裂和剂量单位的释放。当希望释放补充剂时,此类背衬层可被剥离以暴露出可破裂层。此类背衬层可被成形为在可破裂层的整体或其部分的外面。这样的一个背衬层可通过例如粘合剂固定到所述破裂层和/或泡罩层上。
泡罩层可由多种适当的材料制成,其非限制性实例包括聚氯乙烯、热塑性材料、聚烯烃、以及它们的组合。所述泡罩层可以是不透明的、半透明的或者透明的,并且可以是无色的或有色的。
可破裂层可由多种适当的材料制成,其非限制性实例包括金属箔、回火的金属箔、纸板、聚氯乙烯、聚烯烃、聚苯乙烯、聚酯、含氟聚合物树脂、以及它们的组合。所述可破裂层还可被成形为由多个不同材料的层压层组成的层压体,只要其基本操作和可破裂性不受影响。可破裂层可以是任何期望的颜色。
背衬层可由多种适当的材料制成,其非限制性实例包括纸材、塑料、聚氯乙烯、以及它们的组合。背衬层可以是任何期望的颜色。
一个实施方案的初级容器的实例显示于图3中。泡罩包装30可包含单独存在的泡罩外壳31和泡罩层33。泡罩包装30可包括一个或多个泡罩层33和一个可破裂层(未显示),它们的组合包裹着一种或多种宠物食品补充剂。如此,图3的泡罩包装包括至少一个外壳31,所述外壳包含至少一种宠物食品补充剂32,所述宠物食品补充剂包含益生菌组分。所述可破裂层可允许补充剂从所述外壳中、因此也从所述泡罩包装中移出。
本发明的一个实施方案的外壳的横截面显示于图3A中。如图所示,外壳31可以是六边形的。然而应当理解,外壳31可以被制成任何形状,并且其可以是对称的,如图3A所示,或者是不对称的。外壳31可包括唇缘34a和34b,它们构成了图3中的泡罩层33的部分。此外,唇缘34a可终止于表面35,从表面35开始形成外壳31的表面。表面35可从外壳31的内部向外延伸,然后向着所述外壳的内部向内延伸形成表面36,略微形成一个v形。然后,表面36可向下延伸并减小其与垂直面的角度,形成主体表面37。主体表面37可对补充剂的主体塑形。然后,主体表面37可继续向下并终止于底部表面38。底部表面38可对补充剂的顶部塑形,如此,特征表面39可被用于使补充剂的顶部包括标记和/或被制成一种形状,例如爪印形。当然,特征表面39可为任何形状或尺寸,如本文所述。在该结构中,底部表面38和主体表面37限定了容纳补充剂的内部体积。
填充线40可表示当一种混合物或制成的补充剂被填充到外壳31中或在其内硬化时该混合物或补充剂的高度。不受理论的束缚,就制成的补充剂而言,在所述外壳中填充至填充线40可以是有利的。在一个实施方案中,形成补充剂的混合物可被填充到外壳31中。一旦填满,其可在该外壳中硬化,并从而呈该外壳的形状。硬化后,在所述补充剂和外壳的壁之间并不总能实现紧密贴合。换句话说,由于所述补充剂已硬化,其并不总是与外壳31保持紧密贴合。除了其他因素,可能发生一些收缩,也可能发生一些对容器的干扰,所有这些都可将补充剂挤离其与外壳31最初的贴合位置。因此,如果补充剂被挤离,从而不再与外壳紧密贴合,则其可趋于在外壳31内来回运动。因此,表面35和36可共同限定一个褶边,所述褶边可用于避免由于补充剂的运动或挤撞而导致的负面后果。例如,由于表面35和36所形成的褶边可形成v形,并且补充剂的顶部位于或大约位于填充线40处,褶边的表面35可具有一个最高位置,所述最高位置可位于补充剂的最外表面以内,该最外表面可位于表面35和表面36的交汇处。换句话说,外壳或者被置于外壳中并在其中硬化的补充剂的最大半径,大于填充线40处的半径,其中所述最大半径由表面35和表面36的交汇形成。因此,表面35可作为一个阻挡物避免补充剂从外壳31中掉出。当外壳既被用作模具又被用作保存/装运/递送工具时,这种特点可以是非常有利的。
如上文所提及,特征表面39可包括任意的标记和/或被制成某种形状。如图所示,当特征表面39被制成一种形状时,其可形成一个底部表面38外部的表面。当外壳31作为一个泡罩包装的部分时,特征表面39可起到多种作用。例如,当特征表面39形成一个底部表面38外部的表面时,其可为消费者提供一条将所述补充剂从外壳中推出并穿过任何可能存在的密封件的更容易的途径。表面部件39还可起到用一种形状或可与所提供的某种有益效果相关联的标记,表征某种品牌或所述补充剂的某些成分的作用,如本文所述。因此,若泡罩包装30由于某种原因与其包括表明了其中包含的补充剂类型的标记的次级容器分离了,对于消费者来讲,该表面部件39可作为一个方便的标识。
此外,通过表面35和36形成的褶边可允许所述补充剂不变形地移出。移出可通过在褶边中维持一个半径几何形状并且维持褶边的最小深度而实现。并且,所述褶边的一个大约5度的拔模角的存在有助于方便地移出而又不使产品变形。
本发明的实施方案的宠物食品补充剂的包装还可任选地包括一个次级容器。次级容器可包含一个或多个单独的、离散的初级容器和/或与初级容器一起被成形为整合结构。基于所包含的和/或作为其部分成形的初级容器的数量、尺寸和类型,所述次级容器可具有不同形状、尺寸和形式,并且可具有方便携带的尺寸。此类形状和形式的非限制性实例包括圆形、椭圆形、矩形、正方形、三角形、梯形、八边形、爪印形、可折叠式、以及它们的组合。次级容器的非限制性实例包括箱子和纸盒。整合的初级容器和次级容器的非限制性实例包括三叠结构,该结构中,初级容器被固定在次级容器上,而所述次级容器叠在该初级容器的一个或多个部分之上;以及被成型为或结构化为与图书类似的结构,在该结构中,一个或多个初级容器形成类似书页的结构,这些结构被绑定在次级容器外罩之内,形成一个整合结构。所述初级容器和次级容器也可以是单独的离散的元件,并且一个或多个初级容器可被移离次级容器。所述次级容器可由多种材料制成,所述材料的非限制性实例包括纸材、纸板、硬纸板、塑料、以及它们的组合。图4显示了次级容器和初级容器的实施方案。次级容器40可以是纸盒或箱子。初级容器30可以是如图3所示的泡罩包装并且如图4所示被包含于纸盒40中。在该实施方案中,次级容器40还包括标记41,所述标记可有助于指导消费者或兽医师选择适当的补充剂。在该实施方案中,所述标记为文本。标记的其他非限制性实例为形状、物体、图片、品牌、与有益效果相关联的文字,等等。具体的标记描述于下文中。次级容器40还可包括观察孔42。观察孔42可允许籍由它来观察初级容器30的部分。如图4的实施方案所示,图3的补充剂32可通过观察孔42看见。初级容器40的深度43可影响所述补充剂通过观察孔42露出的距离。例如,若深度43足够深以至于其大于补充剂的高度,则所述补充剂将不会从观察孔露出。然而,若所述深度小于补充剂的高度,则所述补充剂或所述初级容器的至少一部分将会从观察孔露出。此外,次级容器40可具有缺口44,消费者可利用该缺口44来帮助将初级容器30从次级容器40中移出。
如上所述且如图4所示,次级容器还可提供一个或多个观察孔,例如观察孔42,观察孔在次级容器中可以是未遮蔽的空隙,或者可以是被某种材料遮蔽的空隙,所述材料的非限制性实例包括塑料。观察孔42可被用于允许对初级容器中的一个产品的观察,并且如上文所述,其可允许补充剂剂由其露出。
次级容器还可有助于初级容器及其所包含的补充剂的存储、运输、配送、展示和/或销售。
同样如上所述且如图4所示,次级容器还可包括一个或多个有助于抓握初级容器和/或次级容器的接收部分,例如缺口44。此类接收部分的非限制性实例包括次级容器中的一个或多个缺口,所述缺口允许对初级容器的接近和抓取,从而允许将所述初级容器从该次级容器移出。
初级容器和次级容器的此类组合可包含易于分配的单位剂量的补充剂。就包含益生菌组分的补充剂而言,此类组合可以是有利的。产品形式如补充剂和初级容器以及次级容器的进一步组合还提高和促进了依从性。例如,益生菌补充剂可具有一个与其相关联的疗程方案,如此一种有益的剂量可以是每天一份补充剂。这样的一种剂量应该易于被消费者处理。已发现,一份补充剂被包含在位于次级容器中的一个初级容器中这样的组合,促进了这样的疗程方案。如此,所述组合通过一种易于使用的剂型提高和促进了疗程依从性。
初级容器和/或次级容器和/或补充剂的自身也可包括标记,该标记可使使用者能够辨识所要基于消费者为其宠物的需求而选择的适当的包装和/或适当的补充剂。如此,所述标记可向消费者传达用于辨识适当的治疗及其应用的信息。
取决于系统和所期望的治疗和/或有益效果,补充剂可以任意多种方式被布置在初级容器内。例如,一个初级容器可包括以多行和/或多列排列的多组补充剂,一个特定行或列的每一补充剂可以是相同类型的补充剂,同时每一特定行或列的补充剂包含不同的益生菌组分或相同的益生菌组分,以提供特定的健康有益效果,如上文所述。如此,在一个实施方案中,作为初级容器的一个泡罩包装可具有三个行或列,并且第一行可包含与第一健康有益效果相关联的益生菌组分,第二行可包含与第二健康有益效果相关联的益生菌组分,第三行可包含与第三健康有益效果相关联的益生菌组分。可使用任意数量的行或列,并且可使用任意数量的益生菌组分和相关的健康有益效果。每一特定行的益生菌组分可包括可与特定的健康有益效果相关联的特定的形状、特定的标记和/或特定的颜色。因此,可以实现一种与多种健康有益效果相关联的补充剂的多包装形式。
此外,可利用颜色来表示补充剂所提供的健康有益效果。颜色可与所提供的特定健康有益效果相关联。例如,绿色可被用于表示胃肠道的有益效果,该有益效果可由补充剂提供。绿色可被用作初级容器和/或次级容器上的标记。任何颜色均可使用,并且任何颜色均可与特定的健康有益效果相匹配。颜色可以任何形式被用作标记。例如,颜色可以是穿过次级容器或初级容器的任意部分的一个或多个条带。颜色可以所述容器的其他形状、条带、轮廓的形式存在。颜色可用于排列中,如下文所详述。可使用一种以上的颜色来表示所提供的一种以上的有益效果。此外,可使用某些其他标记,尤其是可被消费者意识到的标记。可被消费者意识到的标记可包括例如伴侣动物如狗的图片或轮廓图,如图5所示。一只狗的图片或轮廓图50可包括狗品种的任意变型,并且不以任何方式受限于图5所显示的轮廓。在图5中,可包括其他标记以形成可被消费者意识到的标记。作为非限制性实例,狗的轮廓图50可包括靶标区域。靶标区域可以是被突出显示的、指向的、或以任何方式强调的狗的主体部位或区域,并且可表示补充剂所提供的健康有益效果类型在狗或其他伴侣动物身上的区域。例如,靶标区域51可一般位于狗的胃肠道中或在其附近。于是,该位置可向消费者表明,该次级容器内包含的补充剂可以是用于处理狗的肠胃健康问题的补充剂。可使用的狗的其他非限制性区域,例如,可包括以52表示的皮肤和毛皮、以53表示的眼、胃肠道、和狗或伴侣动物可以代表补充剂可提供的健康有益效果的所有其他区域或主体部位。此类健康有益效果已确认于上文中。此外,实际的靶标可以用任意标记表明。非限制性实例包括商标、徽标、星形、靶、突出显示、颜色,等等。例如,商标可被用于治疗的位点处,如位于胃肠道的爪印。当然,任何动物均可使用。还可包括标记的组合,例如,次级包装可具有绿色标记,一只狗可具有位于肠道附近的靶标区域,特别成形的六边形补充剂可显示于观察孔中,并且该次级容器上可使用“GI”字样以便于查看,并且标记的这些组合全部可表示用于治疗狗的胃肠道的特定宠物食品补充剂。当然,这些标记的任何组合均可被用于特定的健康有益效果,并且可与任何其他的包装方面和补充剂形式联合使用。
还可包括色卡或色差表。例如,一家特定公司所销售的任何包含补充剂的次级容器均可包括一张色差表。这样的一张色差表可包括对所有的健康有益效果和初级容器或次级容器上所使用的与之相关联的标记的识别。在图6所示的一个非限制性实例中,色差表60可以是矩形或任何其他形状的,并且可具有色带61-68。色带61-68可以是实际的颜色。可以任何方式用健康有益效果标记色带61-68,其中所述健康有益效果与其所标记的颜色相关联。这样的一条色带可被包括于所有的容器上,如此消费者可知晓一家特定公司的提供特定健康有益效果的补充剂,于是可通过使用颜色容易地找到特定的补充剂和健康有益效果。
补充剂自身可以是任意的多种颜色。此类颜色同样可被用于表示所提供的健康有益效果类型,如上文所述。在一个实施方案中,所述补充剂可一般为米黄色或棕色。在其他实施方案中,所述补充剂可以是任何颜色的。如上所述,颜色可表示健康有益效果。此外还设想,补充剂可包含多种益生菌组分,如此单种补充剂可提供多种健康有益效果。在这种情况下,所述补充剂可以是任何颜色的,或者其可以是多种颜色仿大理石纹的。由于存在多种颜色,此类仿大理石纹可表示多种健康有益效果。
颜色可以用Hunter Lab颜色空间表示。如本领域中所熟知的,Hunter值是反射光的量度,其使用三个参数:L、a和b。一般来讲,“L”表示白色/黑色水平,或者明度,“a”和“b”值则表示对立色坐标。“a”对立色坐标表示,近似地,红色或绿色(正值或负值),而“b”对立色坐标表示黄色或蓝色(正值或负值)。白色可以用“L”值100表示,而黑色用“L”值0表示。灰色可以用介于0和100之间的“L”值和为0的a和b值表示。红色可以用正的“a”值表示,而绿色可以用负的“a”值表示。黄色可以用正的“b”值表示,而蓝色可以用负的“b”值表示。与Hunter值相关联的颜色所包括的和介于其间的所有值均属于本发明的实施方案的范围,并且可以基于其具体的Hunter Lab值表述为红色、绿色、蓝色、黄色、紫色、棕褐色、棕色、米黄色、黑色、白色、灰色、橙色、粉色、淡紫色、粉色、以及它们的组合和混合。
有多种用于测量Hunter Lab颜色及其相关的值的测试方法在色彩领域已为人们所熟知。任何的这些测试方法均可用于本发明的实施方案之中。一种测试方法的非限制性实例公开于下文。
包含颜色的表面于干燥状态和大约500%.+-.2%的环境湿度下接受测试。反射式颜色的测量利用从位于Reston,Va的Hunter Associates Laboratory获得的Hunter LabLabScan XE反射式分光光度计进行。分光光度计被设置为CIELab色标并采用D50光照。观察仪设置在10°。模式设置在45/0°。区域视图设置为0.125″。针对薄膜,孔口尺寸设置为0.20″。针对其他材料,区域视图设置为1.00″,并且孔口尺寸设置为1.20″。在进行样品分析之前,分光光度计利用利用销售商随仪器提供的黑色和白色参考瓷砖先行校准。校准按照制造商的说明书,如LabScan XE用户手册中所述进行,用户手册版本1.1,2001年8月,A60-1010-862。
若参考瓷砖或样品需要清洁,只可使用不含压花、洗涤剂或增白剂的纸巾(例如,Puffs纸巾)。应选择所述物件的外部可见表面上包含所带的待分析颜色的任何样品点。样品点以使其接近被感知的颜色的方式进行选择。被测材料的一个样品被置于分光光度计的样品孔上。包含待分析颜色的样品必须大于样品孔,以保证准确的测量。一块如由制造商提供的白色瓷砖被置于所述外部可见表面后方。读取并记录所述L*,a*和b*值。所述外部可见表面被反复移开和复位,如此获得关于它的至少六个读数。如果可能(例如,待测物件上所带颜色的尺寸对其拥有六个离散的、不重叠的不同样品点的能力不构成限制),每一读数均在所述外部可见表面上的一个充分不同的区域进行,从而使得没有两个样品点是重叠的。若带颜色的区域的尺寸要求样品点重叠,则应仅采用六个样品,并且样品点以任意两个样品点之间的重叠最小化的方式进行选择。对于一个物件的外部可见表面上的特定颜色,将所述读数取平均值,得到L*,a*和b*的报告值。
此外还设想,本发明的容器和产品可向消费者传达信息,如上文所述。这样的信息传达可以是直观的。例如,在使用特定的补充剂之后,消费者可将特定形状的补充剂与特定的健康有益效果相联系。此外,消费者还可将特定颜色的容器或补充剂与特定的健康有益效果相联系。所述的任何其他标记均可被消费者与特定的健康有益效果相联系。因此,在某一点上,所述补充剂和/或容器可向消费者直观地传达信息,从而使其容易地辨识具有特定健康有益效果的补充剂和/或容器,并且消费者的此类辨识可基于与所述容器和/或补充剂相联系的标记。
本发明的实施方案还包括排列。可设置初级容器或次级容器的排列。补充剂容器的排列可包括例如第一容器(例如初级容器或者次级容器)和第二容器(例如初级容器或次级容器)。在一个非限制性实例中,第一容器包括次级容器,所述次级容器容纳补充剂的初级容器,并且第二容器包括次级容器,所述次级容器容纳补充剂的初级容器。第一容器和第二容器可包括文本的或非文本的标记。所述标记可与所述补充剂提供的健康有益效果相联系。所述标记还可包括以次级容器上的条带形式存在的颜色,该颜色由此也与特定的健康有益效果相联系。当然,可以使用多种标记。
排列还可包括第三个、第四个或者任意数量的容器。就特定的产品,例如益生菌补充剂而言,一个排列可包括一家特定公司的整个一组产品。所述排列进一步包括的容器可包括标记。
在一些实施方案中,次级容器可包含初级容器,所述初级容器可包含单一的补充剂,例如提供第一健康有益效果的补充剂,所述第一健康有益效果为例如提高活动性。另一个初级容器可包含单一的另外一种补充剂,例如提供第二健康有益效果的补充剂,所述第二健康有益效果为例如皮肤或毛皮的健康。所述初级容器、补充剂和/或次级容器可包括标记,如上文所述,以使使用者能够辨识所述补充剂提供的适当的健康有益效果,并从而能选择适当的补充剂并予以使用。这些容器可被布置在一个排列中,如上文所述,如此一种活动性相关的补充剂与一种皮肤和毛皮相关的补充剂可在兽医办公室的储物架上提供,或者在用于传达该产品的信息的任何展示中提供。所述健康有益效果可以是任何上文所述的健康有益效果。这样的一种初级容器和/或次级容器的排列还可包括位于初级容器上的标记,如上文所述。包括了初级容器的次级容器,在该包装上可包含至少一个、两个、三个、或任意数量的形式的标记或标记元素。在一个非限制性实例中,包括了初级容器的次级容器,在该容器上可包含至少三种元素或形式的标记。这三个形式的标记可以是狗的一张照片或图片、补充剂,例如处于六边形形式、和品牌,例如IamsTM。其他形式的标记也可被包括在内并且已被描述于上文中。
此外还设想,单个容器,无论其为初级容器还是次级容器,均可包括不同类型的产品或补充剂,如此单个容器内有用于提供第一健康有益效果的第一补充剂和用于提供第二健康有益效果的第二补充剂。还可包括更多的补充剂。次级容器也可包括用于提供第一健康有益效果的补充剂的第一初级容器和用于提供第二健康有益效果的第二初级容器。还可包括更多的容器和补充剂。
还可设想次级容器的多重包装。多重包装可包括一个或多个次级容器,所述次级容器可包含一个或多个初级容器,所述初级容器可包括一份或多份补充剂,其中所述补充剂可提供多种健康有益效果。因此,容器的多重包装可包括用于提供若干种健康有益效果的若干种补充剂。在这样的一个方案中,消费者能够购买包含用于提供多种健康有益效果的多种补充剂的多重包装。
除上文所述的补充剂容器之外,与所述补充剂产品相关联的营销制品,例如店内广告、店内传单、平面广告、期刊广告、广告牌、过道末端展示架、包装机、附加包装、瓦楞纸箱、地面广告、橱窗贴附广告、货架插卡、互联网网站等等,也可包括标记。所述营销制品上的标记可与补充剂所提供的健康有益效果相匹配。
本发明还可包括套装,所述套装可包括本发明的一种或多种与补充剂性质的宠物用产品共同包装的系统,所述宠物用产品例如通常可在宠物用品店找到的任何类型的产品。
补充剂的其他形式
最终的宠物食品补充剂可采取宠物食品的多种形式,例如片剂、胶囊或类似形式,或者其他形式如饼干、咀嚼物、可食薄膜或其他犒赏食物,其目的是作为日常消耗的宠物食品的添加物,而非用作完整的宠物餐食。
多种已知的宠物食品组合物和补充剂以多种形式和材质存在。这些宠物食品组合物大多倾向于是不可挠曲的,例如挤压成型的宠物食品粗磨粒、压片或明胶胶囊。取决于组合物的预期用途或功能,不可挠曲性可以是合乎期望的或不合期望的。例如,适用于健康宠物的产品材质,例如粗磨粒,提供了合乎期望的优点,使得宠物能够容易地食用,从而提供维持生命所必需的营养物质。然而,对于有口腔疾病的宠物,硬性材质可带来“人体”工程学方面的难题。在这些情况下,由于牙齿的缺失或健康问题,产品(例如片剂、挤压成型的或烘焙的组合物)更难在咀嚼过程中碎裂。这一问题尤其存在于易于发生口腔和咀嚼问题的短头颅犬科动物,例如拳师犬、八哥犬等等。此种情况下,更软的组合物会带来更好的依从性和摄食,除非这种形态被发现不为动物所喜欢。与传统的挤压成型或烘焙的组合物相比,能提供较小的碎裂力的补充剂的一个例子是明胶胶囊,但这种材质不能保证所有犬科动物的依从性。洗液、凝胶和调味料也可对有口腔问题的犬类提供较强的吸引力,但它们常常要求消费者将其混合或添加到用于食用的其他物质中,或者必须将其置于一个次级递送载体,例如碗、刷子等等。这些进一步的形式预期均属于本发明的实施方案的范围。
提供可以独立形式配送的、具有益生菌组分有益效果的宠物食品组合物/补充剂同样可以是有利的,所述独立形式可被消费者容易地处置以用于直接饲喂宠物。类似地,宠物食用所述产品以获得有益效果时,应仅需付出很少的努力,无论其所处的生命阶段或健康状态。该实施方案的一个非限制性实例可以是基于脂肪的益生菌犒赏食物的使用,所述犒赏食物在环境温度下为固体,而在目标动物的体温下为液体。如此,所述犒赏食物可用手喂予宠物,而这种形式可在宠物咀嚼时提供松软的材质,这使其适用于所有的品种和生命阶段。此外,如果需要持久咀嚼,所述犒赏食物会在动物嘴里快速液化,从而呈递所期望的健康有益效果。这种进一步的形式预期属于本发明的实施方案的范围。
还可设想补充剂的其他形式。在一个实施方案中,可制造压片。压片可包含上文所述的任何成分。在一个方法中,所述益生菌组分可与赋形剂相结合。赋形剂的非限制性实例包括纤维、其他填料和益菌生素。可以包括粘合剂,其非限制实例包括纤维素、甲基纤维素、聚乙烯基吡咯烷酮和聚乙二醇。这种混合物可被通过流化床旋转造粒机,如本领域的技术人员所知。干燥之后,可加入润滑剂和崩解剂,润滑剂的非限制性实例包括talic、二氧化硅和脂肪,崩解剂的非限制性实例包括淀粉、纤维素、交联聚乙烯基吡咯烷酮、羧甲淀粉钠、钠和羧甲基纤维素甲基纤维素。压缩之后,涂层覆盖可随同包括冷却在内的其他标准程序一起完成,如本领域的一般技术人员所知,从而形成包含益生菌组分的片剂。
另一形式可以是被涂层包被的压片。可制备所述压片。然而,可在压缩之后包括附加步骤以使涂层,例如上文所述的Blommer白色kreemy涂层组分,可被用于包被所述片剂。所得的产品为包含益生菌组分的、涂层包被的压片。
另一形式可以是兵豆状,其可以是经涂层机包被的。兵豆可以用可可脂、益生菌和Blommer涂层混合物制造,如上文所述。基于滚筒的速度,可将所述化混合物于约零下10华氏度置于滚筒上。然后,可在约68华氏度以中档翻滚强度,用涂层机经约三小时完成包被。可加入1至116X糖和1至70胶混合物,在约75至100华氏度进行附加包被。然后可在60至70华氏度经过至少10小时完成干燥。然后可在约100华氏度再次运行涂层机约20分钟,运行过程中,可加入与着色剂混合的1至6.674%的糖浆。可在约85华氏度使涂层机额外运行两分钟,并加入含乙醇的虫胶。然后可以使最终的兵豆成型。
另一形式可以是兵豆,其可以是用涂层机以第二高熔点层包被的。兵豆可以用可可脂、益生菌和Blommer涂层混合物制造,如上文所述。基于滚筒的速度,可将所述混合物于约零下10华氏度置于滚筒上。然后可使涂层机运行约30分钟,并且可加入1至116X糖和1至70胶混合物,在约75至100华氏度进行附加包被。然后可在60至70华氏度经过至少10小时完成干燥。此时,可用涂层机以高熔点脂肪对其进行包被。以高熔点脂肪进行包被后,至少可有以下选择:1)使兵豆冷却以制得终产品;2)使涂层机在85华氏度运行一段附加的时间,所述附加的时间可以是2分钟,并加入含乙醇的虫胶,然后冷却;或者3)在约100华氏度的温度使涂层机运行一段附加的时间,同时混入1至6.674%含白色着色剂的糖浆,然后在85华氏度使涂层机运行一段附加的时间,所述附加的时间可以是2分钟,并加入含乙醇的虫胶,然后冷却。
针对包被第二高熔点层的兵豆,在于约零下10华氏度置于滚筒上之前,存在两种另外的加工选择:1)可简单地将所述混合物滴在传送带上,形成适当大小的兵豆,然后结晶并冷却;之后,可在大约68华氏度用涂层机包被约三小时,并继之以所述采用涂层机的任何加工选择;或者2)可将所述混合物置于凹陷托盘中成型,然后结晶和冷却,然后从所述托盘中移出;之后,可在大约68华氏度用涂层机包被约三小时,并继之以所述采用涂层机的任何加工选择。
可包括晶种。如果熔化或其他方法导致所述补充剂失去了所期望的硬质形态,种晶可用于使所述产品能快速地重新成型为固体形态。如本领域所熟知的,种晶包括当被置于饱和或过饱和溶液中时能长出大晶体的微小单晶体。在本发明的一些实施方案中,若补充剂因高温变成液体,种晶可帮助其结晶。
实施例
在一个实施例中,将制造一种宠物用补充剂或犒赏食物。每一补充剂或犒赏食物将包含大约5×1010CFU的益生菌微生物。每一犒赏食物将重约2.5克,并且具有按总的组合物重量计,10%的益生菌、3.39%的可可脂、86.28%的Blommer白色涂层和0.33%的37542Brown Dispersion OB红辣椒着色剂的组成。该组合物的制备如下:
在具有受控温度和湿度的小室内,大约10%或更低的相对湿度和100华氏度的温度下,将所述可可脂加热至约130华氏度,然后冷却至约105华氏度。在一个混合槽内,将所述可可脂和益生菌彻底混合,直至达到生面团状的稠度。此时,将大约30%的白色涂层加入到所述可可脂和益生菌混合物中,所述白色涂层储存在所述受控小室外的一个槽中,并已被置于约105华氏度约24小时。将该合并的混合物彻底混合约五分钟或直至达到顺滑的稠度。其余的白色涂层被加入到一个独立的混合槽中。此时,将已彻底混合了五分钟或直至达到顺滑稠度的合并的混合物加入到所述独立的混合槽中的其余的白色涂层中。然后将该混合物彻底混合约五分钟。此时,将着色剂加入到所述混合物中。将该最终的混合物彻底混合约20分钟,得到补充剂组合物,所述补充剂组合物已适用于加入用于使其硬化并对其进行包装的模具。
本文所公开的尺寸和值不旨在被理解为严格地限于所述的精确值。相反,除非另外指明,每个这样的尺寸均旨在既表示所述值,也表示围绕此值的功能上等效的范围。例如,公开为“40mm”的尺寸旨在表示“约40mm”。
本文引用的每一文件,包括任何交叉引用的或相关的专利或专利申请,均特此以其全文引入本文,除非明文予以排除或以其他方式受限。对于任何文件的引用并非承认其是有关本文公开或主张的任何发明的现有技术,或者承认其自身或与任何其他参考文献的任何组合教授、建议或公开了任何此类发明。此外,当本文献中术语的任何含义或定义与引入本文以供参考的文献中相同术语的任何含义或定义冲突时,将以赋予本文献中那个术语的含义或定义为准。
虽然已经举例说明和描述了本发明的特定实施方案,但是对于本领域的技术人员来说显而易见的是,在不背离本发明的实质和范围的情况下可做出多个其它改变和变型。因此,权利要求书旨在包括在本发明范围内的所有这样的改变和变型。
Claims (7)
1.一种用于向宠物递送益生菌补充剂的商业制品,所述商业制品包括:
包括泡罩包装的初级容器;
包含活的益生菌组分的补充剂,所述的补充剂包含至少计数为105菌落形成单位数每克补充剂的所述益生菌组分,其中,所述益生菌组分具有至少三个月的储存寿命;
其中所述补充剂被容纳在所述泡罩包装内;
其中所述泡罩包装包括外壳,所述外壳可起作用并可作为所述补充剂的模具,所述外壳包括:
底部表面和主体表面,所述底部表面和主体表面一起限定了用于所述补充剂的内部体积;
围绕所述外壳的顶部设置的唇缘;
在所述主体表面和所述唇缘之间形成的褶边;
其中由所述褶边形成的半径大于由所述唇缘形成的半径;
其中所述补充剂的顶部位于外壳的填充线处,被置于外壳中并在其中硬化的补充剂的最大半径,大于填充线处的半径。
2.如权利要求1所述的商业制品,所述补充剂包括标记。
3.如权利要求2所述的商业制品,其中所述标记包括徽标或商标。
4.如权利要求1所述的商业制品,其中所述外壳包括热成型的塑料。
5.如权利要求1所述的商业制品,其中所述容器包括标记。
6.如权利要求5所述的商业制品,其中所述标记包括颜色,所述的颜色与所述补充剂提供的健康有益效果相关联。
7.如权利要求1所述的商业制品,其中所述补充剂还包括脂肪涂层。
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Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8563522B2 (en) * | 1997-07-08 | 2013-10-22 | The Iams Company | Method of maintaining and/or attenuating a decline in quality of life |
CA2387822C (en) * | 1999-10-15 | 2011-01-04 | Cargill, Incorporated | Fibers from plant seeds and use |
US20050158294A1 (en) | 2003-12-19 | 2005-07-21 | The Procter & Gamble Company | Canine probiotic Bifidobacteria pseudolongum |
US8877178B2 (en) | 2003-12-19 | 2014-11-04 | The Iams Company | Methods of use of probiotic bifidobacteria for companion animals |
AU2006253006B8 (en) | 2005-05-31 | 2011-09-15 | Alimentary Health Ltd | Feline probiotic Lactobacilli |
AU2006253007B2 (en) | 2005-05-31 | 2012-12-20 | Alimentary Health Ltd | Feline probiotic Bifidobacteria |
JP5799299B2 (ja) | 2007-02-01 | 2015-10-21 | ザ・アイムス・カンパニーThe Iams Company | ブドウ糖代謝拮抗物質、アボカド又はアボカド抽出物を使用する、哺乳動物における炎症及びストレスの低下方法 |
US9771199B2 (en) | 2008-07-07 | 2017-09-26 | Mars, Incorporated | Probiotic supplement, process for making, and packaging |
US10104903B2 (en) | 2009-07-31 | 2018-10-23 | Mars, Incorporated | Animal food and its appearance |
WO2012077038A1 (en) | 2010-12-06 | 2012-06-14 | Degama Berrier Ltd. | Composition and method for improving stability and extending shelf life of probiotic bacteria and food products thereof |
ES2712562T3 (es) | 2011-01-14 | 2019-05-13 | Iams Europe B V | Composiciones relacionadas con los carotenoides |
JP6050341B2 (ja) | 2011-06-23 | 2016-12-21 | インノヴァフード アクチエボラグInnovaFood AB | 改善された食品組成物 |
US20130084271A1 (en) * | 2011-10-03 | 2013-04-04 | Kelly Foods Corporation | Probiotic composition for pets and method of providing the same |
US20130295227A1 (en) * | 2012-05-01 | 2013-11-07 | Robbert H. ter Haar | Composition Comprising a Sensitive Ingredient |
US20140349002A1 (en) * | 2013-05-23 | 2014-11-27 | The Iams Company | Ingestible Compositions Containing Criollo Avocado Component |
CN103478421B (zh) * | 2013-09-24 | 2014-10-22 | 大连圣弘医药有限公司 | 一种宠物补钙用功能性食品及其制备方法 |
USD819901S1 (en) * | 2016-03-03 | 2018-06-05 | Stacey Bone | Tray for applying particles to the pad of a paw of a pet |
CN107238996B (zh) * | 2016-03-28 | 2020-10-23 | 中强光电股份有限公司 | 投影系统以及投影画面的校正方法 |
RU2660920C2 (ru) * | 2016-06-06 | 2018-07-11 | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "Кронвет" | Кормовые добавки для сельскохозяйственной птицы |
WO2018089516A1 (en) * | 2016-11-08 | 2018-05-17 | North Carolina State University | Encapsulation of nutritional and/or compounds for controlled release and enhancing their bioavailability by limiting chemical or microbial exposure |
JP2020501503A (ja) * | 2016-12-15 | 2020-01-23 | ソシエテ・デ・プロデュイ・ネスレ・エス・アー | コンパニオンアニマルにおけるリン又は酵素を調節する組成物及び方法 |
MX2019007773A (es) * | 2016-12-27 | 2019-09-09 | Hills Pet Nutrition Inc | Composiciones de alimento para mascotas y metodos para estas. |
WO2018125693A1 (en) * | 2016-12-27 | 2018-07-05 | Hill's Pet Nutrition, Inc. | Pet food compositions and methods for the same |
KR102655260B1 (ko) * | 2017-01-26 | 2024-04-08 | 삼성전자주식회사 | 전자 장치 및 그의 제어 방법 |
KR101957502B1 (ko) * | 2018-08-17 | 2019-03-12 | 이승훈 | 메틸설포닐메탄을 함유하는 비만, 지방간 및 당뇨병 예방 또는 개선용 조성물 |
KR102270024B1 (ko) * | 2019-07-19 | 2021-06-30 | 유한회사 비피코리아 | 반려동물용 고체 유산균 및 이의 제조방법 |
USD938831S1 (en) * | 2020-04-16 | 2021-12-21 | Beaumont Products, Inc. | Packaging for odor absorbers |
JP6846588B2 (ja) * | 2020-07-06 | 2021-03-24 | 神原 秀夫 | 薬剤包装体 |
CN112106883B (zh) * | 2020-09-27 | 2022-05-06 | 烟台中宠食品股份有限公司 | 一种富含益生菌的宠物干粮的制备方法 |
USD917798S1 (en) * | 2020-12-01 | 2021-04-27 | Long Chang Yu Shun OFE-commerce C., Ltd | Pet hair remover |
JP7186209B2 (ja) * | 2020-12-25 | 2022-12-08 | 島貿易株式会社 | 水溶性食物繊維を含む家畜用栄養補助組成物及び該栄養補助組成物を用いた家畜の体調管理方法 |
CA3206753A1 (en) * | 2021-02-01 | 2022-08-04 | Roger Leger | Methods and compositions for increasing protein expression in genetically engineered bacteria |
KR102305149B1 (ko) * | 2021-03-23 | 2021-09-27 | 주식회사 이엘티플러스 농업회사 법인 | 가축용 보조사료 조성물 및 이의 제조방법 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101155518A (zh) * | 2005-04-11 | 2008-04-02 | 爱默思公司 | 包含两种组分的宠物食物组合物 |
Family Cites Families (497)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US571521A (en) * | 1896-11-17 | Package for powders | ||
US1086936A (en) | 1913-05-15 | 1914-02-10 | Malcolm Pounder | Dental massage implement. |
US1503094A (en) | 1923-09-15 | 1924-07-29 | Cramerton Mills Inc | Warp condenser |
US2473773A (en) | 1945-11-16 | 1949-06-21 | Eleanor Kushmaul | Toothbrush |
US2540979A (en) | 1948-04-24 | 1951-02-06 | Smith Kline French Lab | Enteric coating |
US2641548A (en) | 1950-04-06 | 1953-06-09 | Helen W Heinrich | Method of preserving avocados |
BE634858A (zh) | 1962-07-19 | 1900-01-01 | ||
US3398001A (en) | 1963-04-26 | 1968-08-20 | Air Reduction | Process of preparing and packaging frozen avocados |
DE1204363B (de) | 1963-09-10 | 1965-11-04 | Hoffmann La Roche | Verfahren zur Herstellung einer oralen Arzneizubereitung, die ihren Wirkstoff erst im Ileum abgibt |
GB1190387A (en) | 1966-05-24 | 1970-05-06 | Green Cross Corp | Enteric Coated Medicaments |
DE1536074A1 (de) * | 1966-06-28 | 1969-11-13 | Hoefliger & Karg | Tiefziehpackung |
LU54410A1 (zh) | 1967-08-30 | 1969-06-10 | ||
US3677898A (en) | 1969-01-31 | 1972-07-18 | Ajinomoto Kk | Acid protease and method of preparing the same |
US4018908A (en) | 1972-01-28 | 1977-04-19 | Gross George E | Vacuum treatment to remove vaporized liquid from unfrozen cellular substances while keeping the cell walls thereof intact |
US3764715A (en) | 1972-02-04 | 1973-10-09 | Quaker Oats Co | Method of simultaneously extruding and coating a ready-to-eat cereal |
US3916029A (en) | 1972-08-04 | 1975-10-28 | Campbell Soup Co | Centerfilled pet food composition |
US3898132A (en) | 1972-08-24 | 1975-08-05 | Int Feed Improvement Ass Inc | Method of preparing stowable, dormant bacteria |
US3931885A (en) * | 1973-04-30 | 1976-01-13 | Nahill Edmond P | Medicine dispensing system |
US3897572A (en) | 1973-05-16 | 1975-07-29 | Star Kist Foods | Formed meat product |
US3966997A (en) | 1973-12-10 | 1976-06-29 | Shade Foods, Inc. | Chocolate solid wafer and method of manufacture |
US3989822A (en) | 1974-02-14 | 1976-11-02 | Purdue Research Foundation | Weight control compound |
US3922353A (en) | 1974-03-25 | 1975-11-25 | Quaker Oats Co | Shelf stable, high moisture, filled food product |
US4055681A (en) | 1974-06-12 | 1977-10-25 | The Quaker Oats Company | Method of making a dry-type pet food |
CH600790A5 (zh) | 1974-10-04 | 1978-06-30 | Mepros Anstalt | |
US3957974A (en) | 1974-11-05 | 1976-05-18 | Seikenkai | Method for deodorization of excrements |
JPS6038372B2 (ja) | 1975-04-09 | 1985-08-31 | 日清製粉株式会社 | 犬の下痢予防および治療方法 |
US4034115A (en) | 1975-07-29 | 1977-07-05 | Roberts James Gorden | Multi-curdled milk product and the process for the preparation thereof |
US4072766A (en) | 1975-12-22 | 1978-02-07 | The United States Of America As Represented By The Secretary Of Agriculture | Cocoa butter compositions |
JPS52102419A (en) | 1976-02-23 | 1977-08-27 | Seikenkai | Lactic acid producing bacillus preparation |
GB1509339A (en) | 1976-03-08 | 1978-05-04 | Star Kist Foods | Canned pet food |
GB1595054A (en) | 1977-11-14 | 1981-08-05 | Metal Box Co Ltd | Capsules containing micro-organisms |
IL58649A (en) * | 1978-11-10 | 1982-04-30 | Beecham Group Ltd | Pharmaceutical dispensing container |
CH637297A5 (fr) | 1978-12-05 | 1983-07-29 | Nestle Sa | Microbille comprenant un microorganisme et son procede de fabrication. |
US4338346A (en) | 1978-12-21 | 1982-07-06 | The Procter & Gamble Company | Non-nutritive sweetener |
FR2453215A1 (fr) | 1979-04-05 | 1980-10-31 | Rhone Poulenc Ind | Procede d'inclusion de micro-organismes dans une matrice de polymere |
JPS56500874A (zh) * | 1979-07-20 | 1981-07-02 | ||
US4248857A (en) | 1979-08-09 | 1981-02-03 | American Home Products Corporation | Sustained release pharmaceutical compositions |
US4411925A (en) | 1980-01-21 | 1983-10-25 | Pfizer Inc. | Branched amides of L-aspartyl-d-amino acid dipeptides |
US4399163A (en) | 1980-11-05 | 1983-08-16 | Pfizer Inc. | Branched amides of L-aspartyl-D-amino acid dipeptides |
US4423029A (en) | 1981-06-25 | 1983-12-27 | The Procter & Gamble Company | (S)-3-Amino-4-[(S,S)-1-(1-hydroxyethyl)alkyl amino]-4-oxo-butyric acid compounds suitable as non-nutritive sweetners |
US4403623A (en) | 1981-11-16 | 1983-09-13 | Colgate-Palmolive Company | Combined toothbrush and gum massage device |
DE3364233D1 (en) | 1982-03-05 | 1986-07-31 | Quaker France | Animal foodstuff |
US4460610A (en) | 1982-03-23 | 1984-07-17 | A. Duda & Sons, Inc. | Coated fruit juice impregnated plantains |
DE3221425A1 (de) | 1982-06-07 | 1983-12-08 | Boehringer Ingelheim KG, 6507 Ingelheim | Hydrolyseempfindlichen wirkstoff enthaltende, lagerstabile tablette |
US4508741A (en) * | 1982-09-15 | 1985-04-02 | Star-Kist Foods, Inc. | Coated pet food and process for preparation thereof |
US4518696A (en) | 1983-01-11 | 1985-05-21 | Chr. Hansen's Laboratory, Inc. | Stabilized liquid bacterial suspension for oral administration to animals |
JPS59213368A (ja) | 1983-05-17 | 1984-12-03 | Hanamaruki Kk | 果実食品およびその製造法 |
JPS6024153A (ja) | 1983-07-18 | 1985-02-06 | Kagome Kk | アボカドを含有するスプレツド |
US4736849A (en) * | 1983-12-19 | 1988-04-12 | Leonard Walter G | Calendar-oriented pill dispenser |
SE8401332L (sv) | 1984-03-09 | 1985-09-10 | Arla Ekonomisk Foerening | Forfarande for framstellning av kylskapsbredbart matfett |
US4592748A (en) | 1984-05-18 | 1986-06-03 | Vortex Research Corp. | Yoghurt based douche kit and assembly therefor |
CA1276394C (en) | 1984-07-13 | 1990-11-13 | John M. Janusz | Alpha-l-aspartyl-d-phenylglycine esters and amides useful as high intensity sweeteners |
US4647453A (en) | 1984-10-18 | 1987-03-03 | Peritain, Ltd. | Treatment for tissue degenerative inflammatory disease |
JPS61109729A (ja) | 1984-11-05 | 1986-05-28 | Advance Res & Dev Co Ltd | コレステロ−ル低下剤 |
SE463598B (sv) | 1984-11-08 | 1990-12-17 | Chemical Dynamics Sweden Ab | Preparat, avsett att oeka vidhaeftningen av bakterier till mag-tarmkanalen hos maenniskor och djur, samt ett framstaellningsfoerfarande foer detta |
US4594259A (en) | 1984-12-21 | 1986-06-10 | The Procter & Gamble Company | Temperable confectionery compositions having improved mouth melt suitable for chocolate |
US4839281A (en) | 1985-04-17 | 1989-06-13 | New England Medical Center Hospitals, Inc. | Lactobacillus strains and methods of selection |
EP0212747B1 (en) | 1985-08-16 | 1991-04-10 | The Procter & Gamble Company | Drug particles having constant release and immediate release |
DE3678643D1 (de) | 1985-08-16 | 1991-05-16 | Procter & Gamble | Partikel mit konstanter wirkstofffreisetzung. |
JPS62163662A (ja) | 1986-01-11 | 1987-07-20 | Nippon Nousan Kogyo Kk | 犬猫用ペツトフ−ド |
JPS62201823A (ja) | 1986-02-28 | 1987-09-05 | Freunt Ind Co Ltd | 腸内有用細菌含有物およびその製造方法 |
US4764389A (en) | 1986-04-24 | 1988-08-16 | Labarge Universal Ripener, Inc. | Method of accelerating fruit respiration |
US5160745A (en) | 1986-05-16 | 1992-11-03 | The University Of Kentucky Research Foundation | Biodegradable microspheres as a carrier for macromolecules |
CA1300538C (en) | 1986-08-01 | 1992-05-12 | Robert Charley | Maintenance of the viability of microorganisms for use in microbial inoculants |
US4808626A (en) | 1986-09-23 | 1989-02-28 | Monell Chemical Senses Center | Use of 2,5-anhydro-D-mannitol as a food intake modifier |
US4781939A (en) | 1986-10-28 | 1988-11-01 | Nestec, S.A. | Layered meat emulsion product and method of producing same |
US4816259A (en) | 1987-02-12 | 1989-03-28 | Chase Chemical Company, L.P. | Process for coating gelatin capsules |
US4797289A (en) | 1987-03-09 | 1989-01-10 | Reddy Malireddy S | Enhancement of lactobacillus acidophilus growth and viability in yogurt and other cultured dairy products |
EP0698347B1 (en) | 1987-05-01 | 2006-07-12 | Biogaia Biologics Ab | Food composition containing reuterin |
US5413960A (en) | 1987-05-01 | 1995-05-09 | Biogaia Ab | Antibiotic reuterin |
DE3715070A1 (de) | 1987-05-06 | 1988-11-17 | Kneipp Werke Kneipp Mittel Zen | Verfahren zur herstellung von pflanzenauszuegen, insbesondere von pflanzensaeften |
FI77573C (fi) | 1987-05-08 | 1989-04-10 | Orion Yhtymae Oy | Ny konsistens. |
FR2615203B1 (fr) | 1987-05-12 | 1989-08-18 | Agronomique Inst Nat Rech | Inoculum dans lequel les micro-organismes sont conditionnes sous la forme de granules biodegradables, son procede de preparation et ses applications |
GB8713601D0 (en) | 1987-06-10 | 1987-07-15 | Unilever Plc | Fermentation |
US4859377A (en) | 1987-07-10 | 1989-08-22 | The United States Of America, As Represented By The Secretary Of Agriculture | Starch encapsulation of entomopathogens |
US4806368A (en) | 1987-09-16 | 1989-02-21 | Reddy Malireddy S | Shelf life and subsequent growth of lactobacillus acidophilus, propionibacterium shermanii and leuconostoc citrovorum in dietary fiber based supplement preparation |
US4937077A (en) | 1987-09-21 | 1990-06-26 | Eastman Kodak Company | Method for improving feed conversion of meat-producing animals by oral administration of 2-deoxy-D-hexose |
DK686187D0 (da) | 1987-12-23 | 1987-12-23 | Hansens Chr Bio Syst | Veterinaert praeparat |
US4814193A (en) | 1988-04-06 | 1989-03-21 | General Foods Corporation | Reduction of microbial population on surface of food materials |
US5126153A (en) | 1988-05-13 | 1992-06-30 | Basic American Foods, Inc. | Compositions and methods for inhibiting browning of processed produce |
DE68928665T2 (de) | 1988-08-02 | 1998-11-12 | Gastro Services Pty Ltd | Behandlung von gastro-intestinalen krankheiten |
IT1227154B (it) | 1988-08-05 | 1991-03-19 | A Tosi Farmaceutici S R L Nova | Composizioni farmaceutiche per uso ginecologico a base di lattobacilli |
US20020049240A1 (en) | 1994-12-19 | 2002-04-25 | Beecham Group P.1.C. | Novel compounds |
US4997671A (en) | 1988-09-09 | 1991-03-05 | Nabisco Brands, Inc. | Chewy dog snacks |
IT1230576B (it) | 1988-10-20 | 1991-10-28 | Angeli Inst Spa | Formulazioni farmaceutiche per via orale a liberazione selettiva nel colon |
US4889238A (en) * | 1989-04-03 | 1989-12-26 | The Procter & Gamble Company | Medicament package for increasing compliance with complex therapeutic regimens |
AU5254790A (en) | 1989-04-06 | 1990-10-11 | Chugai Seiyaku Kabushiki Kaisha | Process for preparing a therapeutic agent for rotavirus infection |
JPH02265548A (ja) | 1989-04-06 | 1990-10-30 | Yamaguchi Yakuhin Shokai:Kk | 耳鼻科用止血タンポン |
US5540945A (en) | 1989-05-11 | 1996-07-30 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical preparations for oral administration that are adapted to release the drug at appropriate sites in the intestines |
PT94108A (pt) | 1989-05-24 | 1991-02-08 | Asahi Chemical Ind | Preparacao de microorganismos viaveis contendo esporos estabilizada,sua producao e pilulas respectivas |
US4971820A (en) | 1989-06-02 | 1990-11-20 | Canada Packers Inc. | Animal feeds and processes for their manufacture |
JPH06101994B2 (ja) | 1989-08-16 | 1994-12-14 | ユニコロイド株式会社 | 耐消化性腸内有用細菌及びその製法 |
PH27186A (en) | 1989-09-07 | 1993-04-16 | Ciba Geigy Ag | Double-coated granules of disodium pamidronate |
DE3933528C1 (zh) | 1989-10-04 | 1990-12-06 | Effem Gmbh, 2810 Verden, De | |
GB8924288D0 (en) | 1989-10-27 | 1989-12-13 | Unilever Plc | Confectionery fats |
SE465206B (sv) | 1989-12-22 | 1991-08-12 | Eva Grahn | Farmaceutisk beredning foer bekaempning av patogena tarmbakterier |
SU1704744A1 (ru) | 1990-01-05 | 1992-01-15 | Горский Сельскохозяйственный Институт | Способ получени кормового продукта дл молодн ка сельскохоз йственных животных |
US5198227A (en) | 1990-01-22 | 1993-03-30 | Mcneil-Ppc, Inc. | Dual subcoated simulated capsule medicament |
US5344824A (en) | 1990-02-02 | 1994-09-06 | Matsutani Chemical Industries Co., Ltd. | Method for reducing insulin secretion |
US6451341B1 (en) | 1990-02-05 | 2002-09-17 | Thomas J. Slaga | Time release formulation of vitamins, minerals and other beneficial supplements |
DK203090A (da) | 1990-02-28 | 1991-08-29 | Sitia Yomo Spa | Maelkeagtig mousse, dens tilberedning og anvendelse |
FI88856C (fi) | 1990-05-18 | 1997-07-01 | Alko Yhtioet Oy | Foerfarande foer framstaellning av ett fermenterat, huvudsakligen pao havrekli baserat, levande mikroorganismer innehaollande livsmedel |
DE4018392A1 (de) | 1990-06-08 | 1991-12-12 | Kaysan Rolf Dipl Kaufm | Verfahren zur gewinnung von pflanzen-hydrolysaten insbesondere fuer biokosmetische und pharmazeutische zwecke |
FR2663198B1 (fr) | 1990-06-14 | 1993-09-17 | Xeda International | Utilisation de composes antioxydants pour augmenter la resistance des fruits et legumes contre les infections fongiques. |
IE61651B1 (en) | 1990-07-04 | 1994-11-16 | Zambon Spa | Programmed release oral solid pharmaceutical dosage form |
FR2668081B1 (fr) | 1990-10-19 | 1994-11-18 | Lvmh Rech | Procede et appareil de fabrication de particules solides a partir d'un materiau solidifiable en presence d'un agent de solidification en de bons rendements. |
US5292657A (en) * | 1990-12-31 | 1994-03-08 | Pioneer Hi-Bred International, Inc. | Process for preparing rotary disc fatty acid microspheres of microorganisms |
IT1244691B (it) | 1991-01-29 | 1994-08-08 | Sitia Yomo Spa | Mousse lattea, suo impiego per preparare dessert e dessert cosi' ottenuti |
FR2672612B1 (fr) | 1991-02-08 | 1993-06-04 | Rochade | Procede de fabrication d'un nouveau levain lactique, nouveau levain obtenu, fabrication de produits alimentaires a partir de ce levain et produits obtenus. |
AU645392B2 (en) | 1991-02-21 | 1994-01-13 | Unilever Plc | Non-lauric filling fats |
GB9107305D0 (en) | 1991-04-08 | 1991-05-22 | Unilever Plc | Probiotic |
BE1005438A4 (fr) | 1991-10-04 | 1993-07-27 | Raffinerie Tirlemontoise Sa | Compositions de cremes contenant du fructane, procede de preparation de ces compositions et leur utilisation. |
RU1789439C (ru) * | 1991-05-05 | 1993-01-23 | Пензенский Филиал Научно-Исследовательского Института Местной Промышленности | Упаковка дл штучных предметов |
IT1249653B (it) | 1991-06-03 | 1995-03-09 | Teknofarma Spa | Preparato veterinario antiprotozoario per cani e gatti, e procedimentod'impiego |
SE9101860L (sv) | 1991-06-17 | 1992-12-18 | Svenska Mejeriernas Riksforeni | Bredbar smoerfettsbaserad matfettsprodukt och foerfarande foer framstaellning daerav |
FR2678166B1 (fr) | 1991-06-27 | 1993-10-22 | Bioeurope | Compositions cosmetiques contenant des glucooligosaccharides. |
SE469875C (sv) | 1991-07-25 | 1997-04-14 | Probi Ab | Stam av tarmkoloniserande Lactobacillus samt komposition för profylax eller behandling av infektioner i magtarmkanalen |
WO1993002558A1 (en) | 1991-08-01 | 1993-02-18 | Biogaia Biologics Ab | Method and formulation for reducing microbial populations |
US5158800A (en) | 1991-10-08 | 1992-10-27 | Merck & Co., Inc. | Non-sticky, fat-containing confection |
GB2261372A (en) | 1991-11-15 | 1993-05-19 | Gregor Reid | Lactobacillus and skim milk compositions for prevention of urogenital infection |
ES2121926T3 (es) | 1992-01-24 | 1998-12-16 | Gist Brocades Nv | Metodo de preparacion de pelets de alimento. |
EP0563934A1 (de) * | 1992-04-03 | 1993-10-06 | Dr. Karl Thomae GmbH | Blisterstreifen aus Kunststoff-Folien mit Doppel-bzw. Mehrfachdosierung. |
US5286495A (en) | 1992-05-11 | 1994-02-15 | University Of Florida | Process for microencapsulating cells |
DK0768375T4 (da) | 1992-07-06 | 2002-09-16 | Nestle Sa | Mælkesyrebakterier |
EP0577903B1 (fr) | 1992-07-06 | 1997-12-17 | Societe Des Produits Nestle S.A. | Agent antigastrite |
US5501857A (en) | 1992-07-24 | 1996-03-26 | Midwestern Bio-Ag Products & Services, Inc. | Oral nutritional and dietary composition |
HU220103B (hu) | 1992-08-20 | 2001-10-28 | Schering-Plough Corp. | IL-10 új alkalmazása |
US5403799A (en) | 1992-12-21 | 1995-04-04 | W. R. Grace & Co.-Conn. | Process upset-resistant inorganic supports for bioremediation |
IL104441A (en) | 1993-01-19 | 2001-01-28 | Yossi Res Dev Company Of The H | Sponges from hydrocolloids and method for their production |
JP3347381B2 (ja) * | 1993-01-27 | 2002-11-20 | 協和醗酵工業株式会社 | ペットフード |
JP3472317B2 (ja) | 1993-02-26 | 2003-12-02 | 味の素ファルマ株式会社 | 被覆製剤 |
JPH08509965A (ja) | 1993-03-15 | 1996-10-22 | ファーマ・パシフィック・ピーティーワイ・リミテッド | 治療剤および治療方法 |
CA2156486C (en) | 1993-03-16 | 2002-11-12 | Norman J. Stern | Mucosal competitive exclusion flora |
IT1265092B1 (it) | 1993-05-31 | 1996-10-30 | Giuliani Spa | Preparato per uso come integratore alimentare, o dietetico,a rilascio mirato nel colon |
GB9315846D0 (en) | 1993-07-30 | 1993-09-15 | Isis Innovation | Tumour inhibitors |
GB9318439D0 (en) | 1993-09-06 | 1993-10-20 | Zeneca Ltd | Probiotics |
US5501868A (en) | 1993-09-21 | 1996-03-26 | Colgate Palmolive Company | Extruded dog treat food product having improved resistance to breakage |
US5695797A (en) | 1993-10-08 | 1997-12-09 | Nestec S.A. | Coextruded pet food product |
DE4336050C2 (de) * | 1993-10-22 | 1995-11-16 | Onken Gmbh | Tierfutter, insbesondere Alleinfutter für Katzen und Hunde |
US5733568A (en) | 1993-12-03 | 1998-03-31 | Lafor Laboratories Limited | Micro-encapsulated lactobacilli for medical applications |
JP3559790B2 (ja) | 1993-12-20 | 2004-09-02 | 松谷化学工業株式会社 | 食品にビフィズス菌の増殖促進作用を付与する方法 |
US5486507A (en) | 1994-01-14 | 1996-01-23 | Fuisz Technologies Ltd. | Porous particle aggregate and method therefor |
FR2716341B1 (fr) | 1994-02-23 | 1996-05-10 | Gervais Danone Sa | Composition alimentaire comportant un biscuit ou une coque de chocolat et un fourrage à base de produit laitier, fermenté ou non . |
JPH07232049A (ja) | 1994-02-25 | 1995-09-05 | Freunt Ind Co Ltd | 遠心転動造粒コーティング装置および粉粒体の遠心転動造粒コーティング方法ならびにその方法を用いた粉粒体の造粒方法とコーティング方法 |
JP2992945B2 (ja) | 1994-03-11 | 1999-12-20 | カルピス株式会社 | ラクトバチルス・アシドフィルス乳酸菌 |
US5894029A (en) | 1994-03-21 | 1999-04-13 | Purebred Pet Products, Inc. | Method of making pet snack food |
SE9401738D0 (sv) * | 1994-05-19 | 1994-05-19 | Ewos Ab | Bioactive feed |
IT1270216B (it) | 1994-06-14 | 1997-04-29 | Recordati Chem Pharm | Metodo di stabilizzazione di composti biologicamente attivi mediante microgranuli ricoperti sospendibili in fluidi alimentari |
GB2290965A (en) | 1994-07-11 | 1996-01-17 | Therapicon Srl | Multiple layer capsules for drugs |
US5849327A (en) | 1994-07-29 | 1998-12-15 | Advanced Polymer Systems, Inc. | Delivery of drugs to the lower gastrointestinal tract |
JPH08126473A (ja) | 1994-09-08 | 1996-05-21 | Fuji Oil Co Ltd | 油性組成物およびその製法並びにそれを用いた油性被覆菓子 |
US5531988A (en) | 1994-10-28 | 1996-07-02 | Metagenics, Inc. | Bacteria and immunoglobulin-containing composition for human gastrointestinal health |
AU4214596A (en) | 1995-01-23 | 1996-08-01 | Glenda Julieanne Wilkinson | Processing avocado |
US5733540A (en) | 1995-03-08 | 1998-03-31 | Lee; Peter Poon-Hang | Protection from viral infection via colonization of mucosal membranes with genetically modified bacteria |
JPH08242763A (ja) | 1995-03-10 | 1996-09-24 | Morishita Jintan Kk | カプセル化された腸内有用細菌を含有するヨーグルト |
US5573850A (en) | 1995-03-24 | 1996-11-12 | Alliedsignal Inc. | Abrasion resistant quasi monofilament and sheathing composition |
CR5278A (es) | 1995-03-24 | 1996-07-04 | Lilly Co Eli | Formulacion oral de 2-metil-tieno-benzodiacepina |
US5925190A (en) | 1995-06-06 | 1999-07-20 | The University Of Montana | Production of fructose dianhydride products from inulin |
US5643623A (en) | 1995-06-07 | 1997-07-01 | Mars Incorporated | Health food product and its uses |
IT1276783B1 (it) | 1995-06-23 | 1997-11-03 | Bracco Spa | Formulazioni farmaceutiche e dietetiche per la profilassi e la cura di affezioni gastrointestinali |
US5785990A (en) | 1995-07-10 | 1998-07-28 | Merrick's, Inc. | Feed fortifier and enhancer for preruminant calves and method of using same |
SG80553A1 (en) | 1995-07-20 | 2001-05-22 | Tanabe Seiyaku Co | Pharmaceutical preparation in form of coated capsule releasable at lower part of digestive tract |
FI102298B1 (fi) | 1995-09-07 | 1998-11-13 | Oulutech Oy | Menetelmä maitohappobakteerilajien määrittämiseksi ja menetelmään soveltuvia oligonukleotideja |
US6506389B2 (en) | 1995-10-20 | 2003-01-14 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek (Tno) | Adherence factors of non pathogenic microorganisms and applications thereof for screening microorganisms for specific probiotic properties; novel pharmaceutical compositions and food additives comprising such microorganisms and adherence factors |
US5853697A (en) | 1995-10-25 | 1998-12-29 | The United States Of America, As Represented By The Department Of Health & Human Services | Methods of treating established colitis using antibodies against IL-12 |
AU7265596A (en) | 1995-11-02 | 1997-05-22 | Ed. Haas Nahrmittel Gesellschaft M.B.H. | Probiotically acting formulations |
AT405235B (de) | 1995-11-02 | 1999-06-25 | Helmut Dr Viernstein | Probiotisch wirksame formulierung |
AUPN642795A0 (en) | 1995-11-08 | 1995-11-30 | Northfield Laboratories Pty Ltd | Dairy compositions and methods of preparing same |
AUPN698495A0 (en) | 1995-12-06 | 1996-01-04 | Pharma Pacific Pty Ltd | Improved therapeutic formulation and method |
US5858356A (en) | 1995-12-21 | 1999-01-12 | Abbott Laboratories | Lactobacillus acidophilus to inhibit cryptosporidiosis in mammals |
US5854067A (en) | 1996-01-19 | 1998-12-29 | Board Of Regents, The University Of Texas System | Hexokinase inhibitors |
US5962043A (en) | 1996-02-29 | 1999-10-05 | Seal Rock Technologies Incorporated | Weight reduction method for dogs and other pets |
GB2311027B (en) | 1996-03-15 | 1999-10-27 | Johnson & Johnson Medical | Coated bioabsorbable beads for wound treatment |
RU2086248C1 (ru) | 1996-04-02 | 1997-08-10 | Всероссийский государственный научно-исследовательский институт контроля, стандартизации и сертификации ветеринарных препаратов | Пробиотический препарат "стрептобифид" для животных |
US5824779A (en) | 1996-04-26 | 1998-10-20 | Wisconsin Alumni Research Foundation | Phytase-protein-pigmenting concentrate derived from green plant juice |
US5766520A (en) | 1996-07-15 | 1998-06-16 | Universal Preservation Technologies, Inc. | Preservation by foam formation |
US6440464B1 (en) | 1996-06-10 | 2002-08-27 | Viva Life Science | Nutritive composition for cardiovascular health containing fish oil, garlic, rutin, capsaicin, selenium, vitamins and juice concentrates |
US6146681A (en) | 1996-06-14 | 2000-11-14 | Meiji Seika Kaisha Ltd. | Method for producing a porous baked food material |
ATE298363T1 (de) * | 1996-07-09 | 2005-07-15 | Nestle Sa | Verfahren zur sprühtrocknung |
JP3985906B2 (ja) | 1996-07-23 | 2007-10-03 | ビユーラー・アクチエンゲゼルシヤフト | 顆粒製品に油を引くための装置 |
US5871794A (en) | 1996-08-07 | 1999-02-16 | Brito; Jorge Issac | Stabilized guacamole and method for making same |
US5660790A (en) | 1996-08-13 | 1997-08-26 | Litmus Concepts, Inc. | PH and amine test elements |
CA2263534A1 (en) | 1996-09-05 | 1998-03-12 | Nisshin Flour Milling Co., Ltd. | Method of adding fats and oils to porous fodder |
JP2002511777A (ja) * | 1996-10-28 | 2002-04-16 | ゼネラル ミルズ,インコーポレイテッド | 調放性粒子の埋包およびカプセル化 |
ATE271379T1 (de) | 1996-11-06 | 2004-08-15 | Wockhardt Europ Ltd | System zur verzögerten freisetzung säurelabiler substanzen |
ES2283027T3 (es) | 1996-11-29 | 2007-10-16 | Bio K + International Inc. | Fermento lactico que comprende una cepa particular de lactobacilus acidofilus y utilizacion del mismo. |
AU5310898A (en) | 1996-12-20 | 1998-07-17 | Dumex-Alpharma A/S | Release-controlled coated tablets |
US5952033A (en) | 1996-12-24 | 1999-09-14 | Nestec S.A. | Gelatinized cereal product containing oligosaccharide and processes of preparing and using same |
EP0862863B9 (en) * | 1997-01-09 | 2009-08-12 | Societe Des Produits Nestle S.A. | Cereal product containing probiotics |
WO1998035014A2 (en) | 1997-02-11 | 1998-08-13 | Enterprise Ireland Trading As Bioresearch Ireland | Probiotic strains from lactobacillus salivarius and antimicrobial agents obtained therefrom |
FR2759255B1 (fr) | 1997-02-13 | 1999-04-30 | Gervais Danone Co | Barre alimentaire solide assimilable a un produit frais constituee d'une coque et d'un fourrage laitier, procede de preparation d'une telle barre |
AU2809899A (en) | 1997-03-18 | 1999-07-22 | Mendel Institute For Nutraceutical Research Inc, The | Dosing beverage with a bacteria formulation |
US6133323A (en) | 1997-04-09 | 2000-10-17 | The Iams Company | Process for enhancing immune response in animals using β-carotene as a dietary supplement |
ATE493139T1 (de) | 1997-04-18 | 2011-01-15 | Ganeden Biotech Inc | Oberflächige verwendung von probiotischen bacillussporen zur verhinderung oder bekämpfung von mikrobiellen infektionen |
US8486389B2 (en) | 1997-05-23 | 2013-07-16 | Oxthera, Inc. | Compositions and methods for treating or preventing oxalate-related disease |
US6355242B1 (en) * | 1997-05-23 | 2002-03-12 | Ixion Biotechnology, Inc. | Materials and methods for treating or preventing oxalate-related disease |
EP0986314B1 (en) | 1997-06-03 | 2008-09-10 | Ganeden Biotech, Inc. | Probiotic lactic acid bacterium to treat bacterial infections associated with sids |
IT1292636B1 (it) | 1997-06-20 | 1999-02-08 | Ascor Chimici Srl | Composizione a rilascio controllato di sostanze biologicamente attive ad uso zootecnico. |
RU2123343C1 (ru) | 1997-06-26 | 1998-12-20 | Алин Борис Иннокентьевич | Способ получения капсул, содержащих бактерии b.bifidum (бифидумбактерин сухой в капсулах) |
US5976579A (en) | 1997-07-03 | 1999-11-02 | Mclean; Linsey | Nutritional supplement for the prevention and treatment of excessive intestinal permeability |
ATE208205T1 (de) | 1997-07-05 | 2001-11-15 | Nestle Sa | Lactobacilli zur erhöhung der mineralienabsorption durch darmzellen |
US20060116330A1 (en) | 1997-07-08 | 2006-06-01 | The Iams Company | Methods of mimicking the metabolic effects of caloric restriction by administration of mannoheptulose |
US20020035071A1 (en) | 1997-07-08 | 2002-03-21 | Josef Pitha | Mimicking the metabolic effects of caloric restriction by administration of glucose antimetabolites |
US8563522B2 (en) | 1997-07-08 | 2013-10-22 | The Iams Company | Method of maintaining and/or attenuating a decline in quality of life |
US20180000880A9 (en) | 1997-07-08 | 2018-01-04 | The Iams Company | Methods of treating or preventing overweight and obsesity in mammals by administering a composition comprising mannoheptulose |
US6077530A (en) * | 1997-07-28 | 2000-06-20 | Weinstein; Robert | Analgesic dosage units for coordinated administration |
SE510753C2 (sv) | 1997-08-05 | 1999-06-21 | Probi Ab | Användning av en stam av Lactobacillus för tillverkning av ett läkemedel för reduktion av fibrinogenhalten i blod |
US5939117A (en) | 1997-08-11 | 1999-08-17 | Mantrose-Haeuser Co., Inc. | Methods for preserving fresh fruit and product thereof |
US6063414A (en) * | 1997-08-18 | 2000-05-16 | Seal Rock Technologies Incorporated | Combination container and dry pet food for increased shelf life, freshness, palatability, and nutritional value |
FI108512B (fi) | 1997-08-22 | 2002-02-15 | Danisco Finland Oy | Tahnamainen nautittavaksi tarkoitettu koostumus, sen käyttö ja sitä sisältävät tuotteet |
NZ503086A (en) | 1997-08-29 | 2002-03-01 | Upjohn Co | An orally administrable pharmaceutical composition comprising an inner core and two outer layers, which render it substantially free of unpleasant tastes |
JP3400685B2 (ja) | 1997-09-04 | 2003-04-28 | 矢崎総業株式会社 | インサート成形によるターミナルの製造方法 |
EP0904784A1 (en) | 1997-09-22 | 1999-03-31 | N.V. Nutricia | Probiotic nutritional preparation |
SE511025C2 (sv) | 1997-10-03 | 1999-07-26 | Probi Ab | Foderprodukt för häst omfattande Lactobacillus plantarum JI:1 samt Lactobacillus plantarum JI:1 och användning därav |
KR100387245B1 (ko) | 1997-10-17 | 2003-08-19 | 일양약품주식회사 | 유산균의안정화를위한미세장용성코팅과립 |
CZ287956B6 (cs) | 1997-11-04 | 2001-03-14 | Medipharm Cz, S. R. O. | Perorální přípravek k prevenci a léčbě parvovirózy psů |
US6093425A (en) | 1997-11-21 | 2000-07-25 | Princeton Nutrition, L.L.C. | Complete nutritional milk compositions and products |
US5871802A (en) | 1997-12-16 | 1999-02-16 | Moorman Manufacturing Co. | Animal feed pelleting process and animal feed pellets produced therefrom |
AR014129A1 (es) | 1997-12-17 | 2001-02-07 | Nutrasweet Co | Bebida que comprende fundamentalmente un ester n-[n-(3,3-dimetilbutil)-l- alfa-aspartil]-l-fenilamina 1 - metilico, bebida sin alcohol carbonatada,bebida de jugo, bebida envasada caliente y bebida deportiva de bajas calorias. |
PT931543E (pt) * | 1997-12-19 | 2002-09-30 | Merck Patent Gmbh | Comprimidos de varias camadas contendo microorganismos probioticos como por exemplo lactobacilus ou bifidobacterias |
CZ15898A3 (cs) | 1998-01-19 | 1999-11-17 | Medipharm Cz, S. R. O. | Perorální přípravek k prevenci a léčbě infekčních gastroenteritid telat |
IT1298918B1 (it) | 1998-02-20 | 2000-02-07 | Mendes Srl | Uso di batteri dotati di arginina deiminasi per indurre apoptosi e/o ridurre una reazione infiammatoria e composizioni farmaceutiche |
GB2334443A (en) | 1998-02-21 | 1999-08-25 | Tangerine Holdings Limited | Feedstuffs for livestock incorporating a therapeutic substance |
CN100358435C (zh) | 1998-03-12 | 2008-01-02 | 马尔斯公司 | 刺激氧化氮生产的含有多酚和l-精氨酸的制品 |
US6117477A (en) | 1998-03-18 | 2000-09-12 | Kal Kan Foods, Inc. | Multicomponent food product and methods of making and using the same |
DE69941212D1 (de) | 1998-03-23 | 2009-09-17 | Gen Mills Inc | Verkapselung von komponenten in essbaren produkten |
US7201923B1 (en) * | 1998-03-23 | 2007-04-10 | General Mills, Inc. | Encapsulation of sensitive liquid components into a matrix to obtain discrete shelf-stable particles |
FI104405B (fi) | 1998-03-27 | 2000-01-31 | Valtion Teknillinen | Mikro-organismeja sisältävät tärkkelyskapselit ja niiden valmistusmenetelmä |
AU748986B2 (en) | 1998-04-01 | 2002-06-13 | Dsm N.V. | Application of phytase in feed having low content of phytate |
US5932258A (en) | 1998-04-06 | 1999-08-03 | The Iams Company | Composition and process for improving glucose metabolism in companion animals |
PT956858E (pt) | 1998-04-30 | 2002-04-29 | Renata Maria Anna Caval Vesely | Composicoes farmaceuticas contendo lactobacilos para o tratamento de infeccoes vaginais |
DE19819475A1 (de) * | 1998-04-30 | 1999-11-04 | Basf Ag | Trockene Mikroorganismen-Kulturen und Verfahren zu deren Herstellung |
WO2000006127A1 (en) | 1998-07-30 | 2000-02-10 | Warner-Lambert Company | Centerfill delivery system for nutraceuticals |
SE9803871D0 (sv) | 1998-11-11 | 1998-11-11 | Pharmacia & Upjohn Ab | Therapeutic method and formulation |
CN1247036A (zh) | 1998-09-04 | 2000-03-15 | 张燃 | 初乳超氧化物歧化酶营养素 |
US6156355A (en) | 1998-11-02 | 2000-12-05 | Star-Kist Foods, Inc. | Breed-specific canine food formulations |
US6080401A (en) * | 1998-11-19 | 2000-06-27 | Reddy; Malireddy S. | Herbal and pharmaceutical drugs enhanced with probiotics |
DE19856680C1 (de) | 1998-12-09 | 2000-08-17 | Effem Gmbh | Verfahren zum Vakuumbeschichten eines extrudierten Nahrungsmittels |
IT1304170B1 (it) | 1998-12-15 | 2001-03-08 | Novartis Nutrition Ag | Composti organici |
JP2000191519A (ja) | 1998-12-25 | 2000-07-11 | Nippon Kayaku Co Ltd | 薬効成分の不快な官能的性質が隠蔽された速放性粒状物 |
DE19860375A1 (de) | 1998-12-28 | 2000-07-06 | Aventis Res & Tech Gmbh & Co | Alpha Amylase-resistente Stärke zur Herstellung von Nahrungs- und Arzneimittel |
ID29150A (id) | 1999-01-15 | 2001-08-02 | Entpr Ireland Cs | Penggunaan lactobacillus salivarius |
US6767573B1 (en) | 1999-03-10 | 2004-07-27 | Nestec S.A. | Fried pet treats |
EP1034787A1 (en) | 1999-03-11 | 2000-09-13 | Société des Produits Nestlé S.A. | Lactobacillus strains preventing diarrhea caused by pathogenic bacteria |
EP1034788A1 (en) | 1999-03-11 | 2000-09-13 | Société des Produits Nestlé S.A. | Lactic acid bacteria strains capable of preventing diarrhea |
US6692779B2 (en) | 1999-03-26 | 2004-02-17 | The Pillsbury Company | Food products with biocontrol preservation |
US6358555B1 (en) | 1999-03-31 | 2002-03-19 | Hideyuki Takahashi | Process for producing frozen avocados |
US20040161422A1 (en) * | 1999-04-30 | 2004-08-19 | Natarajan Ranganathan | Nutritional compositions comprising probiotics |
US6706263B2 (en) | 1999-04-30 | 2004-03-16 | Kibow Biotech Inc. | Composition for alleviating symptoms of uremia in patients |
HUP0201437A2 (en) | 1999-05-27 | 2002-08-28 | Iams Company | Process and product for enhancing immune response in companion animal using a combination of antioxidants |
IT1309427B1 (it) | 1999-05-28 | 2002-01-23 | Mendes S U R L | Composizione dietetica o farmaceutica utile per la prevenzione o iltrattamento dell'iperossaluria e suo uso |
US6153236A (en) | 1999-06-03 | 2000-11-28 | Balchem Corporation | Low melt encapsulation with high laurate canola oil |
IT1306716B1 (it) | 1999-06-21 | 2001-10-02 | Mendes S U R L | Associazione di batteri lattici e suo uso per la prevenzione e/o iltrattamento terapeutico di infezioni e di stati infiammatori. |
US6375956B1 (en) * | 1999-07-22 | 2002-04-23 | Drugtech Corporation | Strip pack |
DE19937361A1 (de) | 1999-08-12 | 2001-02-22 | Merck Patent Gmbh | Orale Darreichungsform |
US6737089B2 (en) | 1999-08-27 | 2004-05-18 | Morinda, Inc. | Morinda citrifolia (Noni) enhanced animal food product |
DE60039177D1 (de) | 1999-09-07 | 2008-07-24 | Nestle Sa | Verfahren zur verbesserung der haut und des pelzes von haustieren |
US7211280B1 (en) * | 1999-09-09 | 2007-05-01 | Nestec S.A. | Condition of elderly pets |
NZ511870A (en) | 1999-09-22 | 2004-02-27 | Nestle Sa | Method for increasing pet activity |
US6500463B1 (en) | 1999-10-01 | 2002-12-31 | General Mills, Inc. | Encapsulation of sensitive components into a matrix to obtain discrete shelf-stable particles |
CN1281220C (zh) * | 1999-10-26 | 2006-10-25 | 雀巢制品公司 | 乳酸菌在制备治疗和/或预防贾第鞭毛虫病药物中的应用 |
US6394803B1 (en) * | 1999-12-09 | 2002-05-28 | Ivoclar Ag | Mixing arrangement |
US6251478B1 (en) | 1999-12-22 | 2001-06-26 | Balchem Corporation | Sensitive substance encapsulation |
AU2461201A (en) | 1999-12-23 | 2001-07-03 | Regents Of The University Of California, The | Interventions to mimic the effects of calorie restriction |
US6406853B1 (en) | 1999-12-23 | 2002-06-18 | The Regents Of The University Of California | Interventions to mimic the effects of calorie restriction |
EP1251747B1 (en) * | 2000-01-18 | 2012-01-25 | Société des Produits Nestlé S.A. | Pet food composition for treating helicobacter species in pets |
US20010036488A1 (en) | 2000-01-18 | 2001-11-01 | Syuichi Hayashi | Anti-obestic composition |
US20030060503A1 (en) | 2000-01-25 | 2003-03-27 | Juvenon, Inc. | Nutritional supplements for mature pets |
JP3888064B2 (ja) | 2000-01-27 | 2007-02-28 | 田辺製薬株式会社 | 徐放性製剤およびその製法 |
US7115297B2 (en) | 2000-02-22 | 2006-10-03 | Suzanne Jaffe Stillman | Nutritionally fortified liquid composition with added value delivery systems/elements/additives |
JP2001309753A (ja) | 2000-04-28 | 2001-11-06 | Natl Fedelation Of Agricult Coop Assoc | 犬特有の感染症の予防・治療用ドッグフード |
US20030104090A1 (en) | 2000-05-05 | 2003-06-05 | Levy Pedro E. | Supplements containing annatto extracts and carotenoids and methods for using the same |
PL207930B1 (pl) * | 2000-05-25 | 2011-02-28 | Nestle Sa | Zastosowanie wyizolowanego probiotycznego szczepu bakterii kwasu mlekowego o aktywności probiotycznej, kompozycja pokarmowa i izolowany szczep bakterii kwasu mlekowego |
FR2809312B1 (fr) | 2000-05-25 | 2002-07-12 | Gervais Danone Sa | Utilisation de l. casei dans des compositions immunostimulantes |
US20010048955A1 (en) | 2000-05-30 | 2001-12-06 | Foreman Gary A. | Method of feeding an animal a balanced meal |
DE10029079B4 (de) * | 2000-06-13 | 2006-04-20 | Mars Inc. | Probiotische Mikroorganismen enthaltendes Nahrungsmittelerzeugnis |
WO2001098516A2 (en) * | 2000-06-19 | 2001-12-27 | Regents Of The University Of Minnesota | Siderophores-producing bifidobacteria thereby and uses thereof |
WO2002005829A2 (en) * | 2000-07-17 | 2002-01-24 | Chr. Hansen A/S | Methods and formultations with probiotic microorganisms and medicaments |
HUP0302049A2 (hu) | 2000-07-19 | 2003-09-29 | Compagnie Gervais Danone | Életképes élesztżsejteket tartalmazó, hżkezelt élelmiszer-ipari termékek és eljárás elżállításukra |
DE60135760D1 (de) | 2000-08-01 | 2008-10-23 | Oryza Oil & Fat Chem | Nachtkerzensamenextrakte als inhibitoren der zuckerabsorption und deren herstellungsprozess |
RU2185838C2 (ru) | 2000-08-09 | 2002-07-27 | Овод Анатолий Семенович | Способ профилактики колибактериоза телят |
US6592863B2 (en) * | 2000-08-22 | 2003-07-15 | Nestec S.A. | Nutritional composition |
WO2002016554A1 (fr) | 2000-08-25 | 2002-02-28 | Wakamoto Pharmaceutical Co.,Ltd. | Produits probiotiques contenant une bacterie de l'acide lactique |
RU2294366C2 (ru) * | 2000-09-25 | 2007-02-27 | Сосьете Де Продюи Нестле С.А. | Трансформированные молочно-кислые бактерии, снижающие склонность к проявлению аллергических реакций, и их применение |
AU2002220587B2 (en) * | 2000-10-06 | 2006-06-29 | Societe Des Produits Nestle S.A. | Use of probiotic lactic acid bacteria for balancing the skin's immune system |
US6887493B2 (en) | 2000-10-25 | 2005-05-03 | Adi Shefer | Multi component controlled release system for oral care, food products, nutraceutical, and beverages |
CA2359812C (en) | 2000-11-20 | 2004-02-10 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures |
US6802422B2 (en) * | 2000-12-12 | 2004-10-12 | Multi-Comp, Inc. | Sealed blister assembly |
IL156490A0 (en) | 2000-12-18 | 2004-01-04 | Probiohealth | Probiotic compounds derived from lactobacillus casei strain ke01 |
KR20020050048A (ko) | 2000-12-20 | 2002-06-26 | 박흥재 | Lactobacillus sp.DW-1 동정 시스템 |
US20020119237A1 (en) * | 2000-12-22 | 2002-08-29 | Hevey Maurice O. | Medium and method for delivery of edible materials subject to degradation by oxidation and hydrolysis |
JP2002191297A (ja) | 2000-12-27 | 2002-07-09 | Matsushita Environment Airconditioning Eng Co Ltd | 食品衛生管理支援装置 |
AUPR272901A0 (en) | 2001-01-25 | 2001-02-22 | Gainful Plan Limited | Method of preparing biological materials and preparations produced using same |
EP1227152A1 (en) * | 2001-01-30 | 2002-07-31 | Société des Produits Nestlé S.A. | Bacterial strain and genome of bifidobacterium |
US20030190314A1 (en) | 2001-01-30 | 2003-10-09 | The Lauridsen Group | Methods and compositions of treatment for modulating the immune system of animals |
US6588180B2 (en) * | 2001-02-02 | 2003-07-08 | R. P. Scherer Technologies, Inc. | Constricted neck blister pack and apparatus and method for making the same |
JP2004531477A (ja) * | 2001-02-06 | 2004-10-14 | ソシエテ デ プロデユイ ネツスル ソシエテ アノニム | 乳酸菌及びビフィズス菌による内毒素結合 |
EP1408760B1 (en) * | 2001-02-19 | 2009-04-01 | Société des Produits Nestlé S.A. | Consumable product containing probiotics |
US6586027B2 (en) | 2001-02-23 | 2003-07-01 | T.F.H. Publications, Inc. | Health chew toy |
EP1239032A1 (en) * | 2001-03-02 | 2002-09-11 | Société des Produits Nestlé S.A. | Lactic acid bacteria as agents for treating and preventing allergy |
JP2004519241A (ja) * | 2001-03-09 | 2004-07-02 | ソシエテ デ プロデユイ ネツスル ソシエテ アノニム | 高齢化に伴う生理的障害を改善し寿命を延ばす組成物 |
US6740350B2 (en) | 2001-03-12 | 2004-05-25 | Bristol-Myers Squibb Company | Confectionery compositions containing fiber |
WO2002074285A1 (en) | 2001-03-16 | 2002-09-26 | Andrx Corporation | Controlled release sulfonylurea formulation |
EP1243273A1 (en) * | 2001-03-22 | 2002-09-25 | Societe Des Produits Nestle S.A. | Composition comprising a prebiotic for decreasing infammatory process and abnormal activation of non-specific immune parameters |
AU2002249531A1 (en) | 2001-04-02 | 2002-10-28 | Alimentary Health Limited | Immunotherapy based on dendritic cells |
WO2002085415A1 (en) | 2001-04-17 | 2002-10-31 | Biomatrix, Inc | Non-digestible sugar-coated products and process |
EP1260227A1 (en) * | 2001-05-23 | 2002-11-27 | Societe Des Produits Nestle S.A. | Lipoteichoic acid from lactic acid bacteria and its use to modulate immune responses mediated by gram-negative bacteria, potential pathogenic gram-positive bacteria |
DE20110409U1 (de) | 2001-06-26 | 2001-09-27 | Wikana Keks Und Nahrungsmittel | Masse für Lebensmittel |
US7081478B2 (en) | 2001-06-29 | 2006-07-25 | Chrysantis, Inc. | Mixed zeaxanthin ester concentrate and uses thereof |
EP1277412A1 (en) | 2001-07-17 | 2003-01-22 | Societe Des Produits Nestle S.A. | Pet food composition for regulating body weight and preventing obesity and related disorders in pets |
US20030092163A1 (en) | 2001-07-26 | 2003-05-15 | Collins John Kevin | Probiotic bifidobacterium strains |
PE20030274A1 (es) | 2001-07-26 | 2003-05-08 | Alimentary Health Ltd | Cepas de lactobacillus salivarius |
PE20030283A1 (es) | 2001-07-26 | 2003-05-01 | Alimentary Health Ltd | Cepas de lactobacillus casei |
US20030026875A1 (en) | 2001-07-31 | 2003-02-06 | Aguilar Carlos A. | Multi-compartment pet food container |
US7666459B2 (en) | 2001-09-12 | 2010-02-23 | The Procter & Gamble Company | Pet food compositions |
US7842329B2 (en) | 2001-09-18 | 2010-11-30 | Nestec S.A. | Pet food product and method of manufacture |
US20070098784A1 (en) * | 2001-09-28 | 2007-05-03 | Nutraceutix, Inc. | Delivery system for biological component |
JP2003120965A (ja) | 2001-10-11 | 2003-04-23 | Toyo Eng Works Ltd | 除湿空調装置 |
US6624162B2 (en) | 2001-10-22 | 2003-09-23 | Pfizer Inc. | Imidazopyridine compounds as 5-HT4 receptor modulators |
US6896914B2 (en) | 2001-10-26 | 2005-05-24 | David I. Chapnick | Method for normalizing insulin levels |
US20050164978A1 (en) | 2001-10-26 | 2005-07-28 | Chapnick David I. | Method for normalizing insulin levels |
AU2002339112B2 (en) * | 2001-11-12 | 2007-10-11 | Mars, Incorporated | Foodstuff |
US7008648B2 (en) | 2001-11-16 | 2006-03-07 | Novartis Nutrition Ag | Plant derived or derivable material with appetite suppressing activity |
BRPI0117180B8 (pt) | 2001-11-23 | 2021-05-25 | Procter & Gamble | composição farmacêutica em uma forma de unidade sólida de dosagem para a administração oral a um ser humano ou animal inferior |
EP1325681A1 (en) * | 2001-12-11 | 2003-07-09 | Société des Produits Nestlé S.A. | Composition for promotion of bone growth and maintenance of bone health |
EP1319410A1 (en) * | 2001-12-11 | 2003-06-18 | Société des Produits Nestlé S.A. | Use of micro-organisms for a directed delivery of substances to specific parts of the gut |
DE60238504D1 (de) * | 2001-12-20 | 2011-01-13 | Nestle Sa | Gelkapseln oder tabletten enthaltendes nahrungsmittel |
EP1471797B1 (en) * | 2002-01-15 | 2008-03-05 | Mars Incorporated | Methods and products produced thereby to stabilize multi-layer food products |
US20030143293A1 (en) | 2002-01-31 | 2003-07-31 | Sergei Shushunov | Compositions and methods for treating diarrhea |
ES2297181T3 (es) * | 2002-02-21 | 2008-05-01 | Societe Des Produits Nestle S.A. | Una composicion fotoprotectora para la piel, de administracion oral. |
JP2005517419A (ja) * | 2002-02-21 | 2005-06-16 | ソシエテ デ プロデユイ ネツスル ソシエテ アノニム | 皮膚の光防護に適するペットフード組成物 |
EP1344458A1 (en) * | 2002-03-12 | 2003-09-17 | Société des Produits Nestlé S.A. | Probiotic delivery system |
DE10217970A1 (de) * | 2002-04-22 | 2003-11-13 | Henkel Kgaa | Durchdrückverpackung |
DE10213280A1 (de) * | 2002-03-25 | 2003-10-23 | Mars Inc | Proteinhaltiges Nahrungsmittelerzeugnis und Verfahren zu seiner Herstellung |
US6681935B1 (en) * | 2002-04-02 | 2004-01-27 | Graham L. Lewis | Method of providing a therapeutic regimen and prefabricated container therefor |
ATE492166T1 (de) | 2002-04-05 | 2011-01-15 | Nestle Sa | Zusammensetzungen und verfahren zur verbesserung von lipidassimilation in haustieren |
US7670612B2 (en) | 2002-04-10 | 2010-03-02 | Innercap Technologies, Inc. | Multi-phase, multi-compartment capsular delivery apparatus and methods for using same |
US20030194423A1 (en) * | 2002-04-15 | 2003-10-16 | Mars, Inc. | Composition for enhancing nutritional content of food |
US20040001817A1 (en) * | 2002-05-14 | 2004-01-01 | Giampapa Vincent C. | Anti-aging nutritional supplement |
US20030215547A1 (en) | 2002-05-16 | 2003-11-20 | Leyh Joseph Conrad | Pet treat coating composition and process |
EP1364586A1 (en) * | 2002-05-24 | 2003-11-26 | Nestec S.A. | Probiotics and oral tolerance |
US8142810B2 (en) | 2002-05-30 | 2012-03-27 | The Procter & Gamble Company | Dietary method for modulating glucose metabolism and associated conditions and increasing longevity |
GB0212975D0 (en) * | 2002-06-06 | 2002-07-17 | Mars Uk Ltd | Mammalian animal composition |
US6733795B2 (en) | 2002-07-30 | 2004-05-11 | Laboratoires Expanscience | Method for producing an avocado leaf extract rich in furanic lipids |
US20050208163A1 (en) | 2002-07-31 | 2005-09-22 | Brovelli Ernesto A | Compositions containing avocado leaf extract for lowering cholesterol levels |
ITBO20020564A1 (it) | 2002-09-06 | 2004-03-07 | Alfa Wassermann Spa | Bifidobatteri e preparazioni che li contengono. |
KR20040024774A (ko) | 2002-09-16 | 2004-03-22 | 이성표 | 혈액형별 체질에 적합하도록 제조한 생약 조성물 |
JP2004173675A (ja) | 2002-10-02 | 2004-06-24 | Takayuki Hirano | 耐化学剤性を有する菌封入物および製造方法 |
US8168170B2 (en) | 2002-10-03 | 2012-05-01 | The Procter And Gamble Company | Compositions having an inner core and at least three surrounding layers |
BR0315629A (pt) | 2002-11-15 | 2005-08-23 | Warner Lambert Co | Método para baixar a cpr e reduzir a inflamação sistêmica |
WO2004051219A2 (en) | 2002-11-27 | 2004-06-17 | Molecular Nanosystems, Inc. | Nanotube chemical sensor based on work function of electrodes |
US7179460B2 (en) | 2002-12-05 | 2007-02-20 | Danisco A/S | Bacterial composition and its use |
US6835397B2 (en) | 2002-12-23 | 2004-12-28 | Balchem Corporation | Controlled release encapsulated bioactive substances |
KR20050098244A (ko) | 2003-01-10 | 2005-10-11 | 쓰레솔드 파마슈티컬스, 인코포레이티드 | 2-데옥시글루코오스를 사용한 암 치료 방법 |
US7122370B2 (en) | 2003-01-14 | 2006-10-17 | Randolph Stanley Porubcan | Formulations to increase in vivo survival of probiotic bacteria and extend their shelf-life |
EP1594544B1 (en) | 2003-01-31 | 2016-04-06 | Childrens Hospital Los Angeles | Oral compositions of fenretinide having increased bioavailability and methods of using the same |
GB0303716D0 (en) | 2003-02-18 | 2003-03-19 | Mars Uk Ltd | Food product and process |
EP1613338A4 (en) | 2003-03-21 | 2009-06-24 | Madeleine M Joullie | TAMANDARIN ANALOGUES, FRAGMENTS THEREOF AND METHODS OF MAKING AND USING THE SAME |
DK1610617T3 (da) | 2003-03-25 | 2009-03-30 | Gen Mills Inc | Fremgangsmåde til behandling af avocadoer og fremgangsmåde til fremstilling af guacomole deraf |
GB0308104D0 (en) * | 2003-04-08 | 2003-05-14 | Novartis Nutrition Ag | Organic compounds |
US20040265279A1 (en) | 2003-05-08 | 2004-12-30 | Timothy Dinan | Probiotics in the treatment of atypical depression and other disorders characterized by hypothalamic pitiuitary-adrenal axis over-activity |
US20040234579A1 (en) * | 2003-05-22 | 2004-11-25 | Mark D. Finke, Inc. | Dietary supplements and methods of preparing and administering dietary supplements |
FR2855374B1 (fr) | 2003-05-26 | 2007-06-01 | Roquette Freres | Procede de drageification dure ameliore |
US20060147962A1 (en) * | 2003-06-16 | 2006-07-06 | Mars, Inc. | Genotype test |
ES2416287T3 (es) * | 2003-06-23 | 2013-07-31 | Nestec S.A. | Empleo de una fórmula nutritiva para la función óptima de la barrera intestinal |
EP2236131A3 (en) | 2003-07-01 | 2011-03-02 | President and Fellows of Harvard College | Sirt1 modulators for manipulating cell/organism lifespan/stress response |
US20050271643A1 (en) | 2003-08-14 | 2005-12-08 | Iryna Sorokulova | Bacterial strains, compositions including same and probiotic use thereof |
US20050042338A1 (en) * | 2003-08-22 | 2005-02-24 | The Iams Company | Pet food container |
JP4989969B2 (ja) * | 2003-09-04 | 2012-08-01 | ファーマデザイン インコーポレイテッド. | 錠剤の受容と小出しのための錠剤受けスリーブを備えるケース |
US7235276B2 (en) * | 2003-09-24 | 2007-06-26 | General Mills Ip Holdings Ii, Llc | High protein puffed food product and method of preparation |
US20050074519A1 (en) | 2003-10-01 | 2005-04-07 | Sensient Flavors Inc. | Method for the production of natural botanical extracts |
GB0323668D0 (en) * | 2003-10-09 | 2003-11-12 | Nestec Sa | Fat-based confectionery product coated with a film forming agent making it resistant to heat and shape stable to heat |
US20050100559A1 (en) | 2003-11-07 | 2005-05-12 | The Procter & Gamble Company | Stabilized compositions comprising a probiotic |
CN103636926A (zh) | 2003-11-26 | 2014-03-19 | 希尔氏宠物营养品公司 | 减少伴侣动物粪便气味的方法 |
US7687077B2 (en) * | 2003-11-26 | 2010-03-30 | Hill's Pet Nutrition, Inc. | Method to reduce stool odor of companion animals |
BRPI0417723A (pt) * | 2003-12-18 | 2007-04-03 | Nestec Sa | composição para melhorar a saúde da pele, cabelo e tegumento contendo flavanonas |
US7785635B1 (en) | 2003-12-19 | 2010-08-31 | The Procter & Gamble Company | Methods of use of probiotic lactobacilli for companion animals |
US8877178B2 (en) | 2003-12-19 | 2014-11-04 | The Iams Company | Methods of use of probiotic bifidobacteria for companion animals |
US20050152884A1 (en) | 2003-12-19 | 2005-07-14 | The Procter & Gamble Company | Canine probiotic Bifidobacteria globosum |
US8894991B2 (en) | 2003-12-19 | 2014-11-25 | The Iams Company | Canine probiotic Lactobacilli |
US20050158294A1 (en) * | 2003-12-19 | 2005-07-21 | The Procter & Gamble Company | Canine probiotic Bifidobacteria pseudolongum |
TW200524539A (en) | 2003-12-23 | 2005-08-01 | Rohm & Haas | A method to reverse ethylene inhibitor responses in plants |
GB0330009D0 (en) * | 2003-12-24 | 2004-01-28 | Ferrosan As | Probiotic tablet formulations |
DE102004004030A1 (de) | 2004-01-27 | 2005-08-18 | Mars Inc. | Nahrungsmittelerzeugnis und Verfahren zu dessen Herstellung |
US20050266438A1 (en) | 2004-03-16 | 2005-12-01 | The Regents Of The University Of California | Genetic networks regulated by attenuated GH/IGF1 signaling and caloric restriction |
GB0406654D0 (en) | 2004-03-24 | 2004-04-28 | Mars Inc | Foodstuff |
CA2563702A1 (en) * | 2004-04-20 | 2005-12-01 | The University Of Chicago | Probiotic compounds from lactobacillus gg and uses therefor |
FR2869541B1 (fr) | 2004-04-30 | 2007-12-28 | Expanscience Sa Lab | Utilisation d'une composition comprenant du d-mannoheptulose et/ou du perseitol dans le traitement et la prevention des maladies liees a une modification de l'immunite innee |
US9089576B2 (en) | 2004-04-30 | 2015-07-28 | Laboratoires Expanscience | Medicament comprising a peptide extract of avocado, which is intended for the treatment and prevention of illnesses that are linked to an immune system deficiency or oxidative stress or skin ageing or dry skin |
FR2869543B1 (fr) | 2004-04-30 | 2006-07-28 | Expanscience Laboratoires Sa | Medicament comprenant un extrait peptidique d'avocat destine au traitement et la prevention des maladies liees a une deficience du systeme immunitaire |
CA2569249C (en) | 2004-05-10 | 2012-08-14 | The Iams Company | Processes for preparing plant matter extracts and pet food compositions |
US20090252834A1 (en) | 2004-05-10 | 2009-10-08 | Michael Griffin Hayek | Compositions comprising glucose anti-metabolites |
US20050249837A1 (en) | 2004-05-10 | 2005-11-10 | The Procter & Gamble Company | Processes for preparing plant matter extracts and pet food compositions |
EP1750674A4 (en) | 2004-05-27 | 2012-05-23 | Advanced Bionutrition Corp | MICROPARTICLES FOR THE ORAL LEVY |
US20050276882A1 (en) | 2004-06-11 | 2005-12-15 | Bishop William W | Pet food, pet food pellets and process for making same |
JP2005348698A (ja) * | 2004-06-14 | 2005-12-22 | Yonezawa Biru System Service:Kk | ケフィア粒から分離された微生物とこの微生物あるいはそれを含む微生物群を培養して得られる微生物培養物ならびにそれらを用いた製品 |
AU2005258021B2 (en) | 2004-06-17 | 2008-12-18 | Wisconsin Alumni Research Foundation | Compounds and methods for treating seizure and paroxysmal disorders |
CA2570126C (en) | 2004-07-01 | 2014-08-12 | General Mills, Inc. | Cultures encapsulated with chocolate food products coated with chocolate and methods of preparation |
MXPA06015203A (es) | 2004-07-01 | 2007-03-27 | Nestec Sa | Formulacion de dieta para osteoartritis canina. |
US20080305210A1 (en) | 2004-07-01 | 2008-12-11 | General Mills, Inc. | Cultures Encapsulated With Compound Fat Breakfast Cereals Coated With Compound Fat and Methods of Preparation |
JP2006020581A (ja) | 2004-07-08 | 2006-01-26 | Cdom:Kk | ペット用食品及びその製造方法 |
US20060008511A1 (en) * | 2004-07-08 | 2006-01-12 | Jhy-Jhu Lin | Probiotic products for pet applications |
US7935334B2 (en) * | 2005-07-07 | 2011-05-03 | Imagilin Technologies, LLC | Probiotics as alternative medicines against infectious diseases |
US20060029685A1 (en) | 2004-07-30 | 2006-02-09 | Henderson Todd R | Combination of unsaponifiable lipids combined with polyphenols and/or catechins for the protection, treatment and repair of cartilage in joints of humans and animals |
US20060070895A1 (en) * | 2004-08-16 | 2006-04-06 | Faisal Khawaja | Drug administration kit |
JP2006055145A (ja) | 2004-08-19 | 2006-03-02 | Kosshi:Kk | ペットフード及びペットフードの提供方法 |
US20060062892A1 (en) | 2004-09-17 | 2006-03-23 | Merrick Tyler W | Dry pet food with kibble, dried vegetables and dried meat jerky pieces |
DE602004013441T2 (de) | 2004-09-21 | 2009-06-04 | Nestec S.A. | Verbesserung der Lebensdauer alter Katzen |
ITMI20041820A1 (it) * | 2004-09-24 | 2004-12-24 | Ascor Chimici Srl | Composizione in micro-pellets a rilascio controllato di sostanze fisiologicamente attive, procedimento di preparazione e relativo impiego nel settore zootecnico. |
US20070286935A1 (en) | 2004-10-07 | 2007-12-13 | Nestec S.A. | Bioactive Compositions, Natural Methods of Producing Them and Computational Methods for Designing Natural Production Processes |
FR2876876B1 (fr) * | 2004-10-22 | 2007-02-16 | Gervais Danone Sa | Protection d'ingredients alimentaires bioactifs par l'utilisation de microorganismes presentant une capacite de metabolisation reduite |
FR2876875B1 (fr) * | 2004-10-22 | 2007-02-02 | Gervais Danone Sa | Protection d'ingredients alimentaires bioactifs par encapsulation |
JP4253296B2 (ja) | 2004-12-16 | 2009-04-08 | 尚文 石川 | 健康美容食品 |
WO2006066244A2 (en) | 2004-12-17 | 2006-06-22 | Cash Alan B | Method for extending lifespan and delaying the onset of age-related disease |
SE528308C2 (sv) | 2004-12-21 | 2006-10-17 | Stora Enso Ab | Förpackning omfattande en hylsa och en insats samt förpackningsämne för bildande av nämnda förpackning |
DK2263473T3 (en) | 2005-02-08 | 2018-06-06 | Dragsbaek As | mixture Product |
CN101111164B (zh) * | 2005-02-10 | 2013-05-29 | 弗门尼舍有限公司 | 具有封装香料包衣的加热食品 |
US20080208253A1 (en) | 2006-05-18 | 2008-08-28 | Dreyfuss Peter J | Self-punching swivel anchor and method for knotless fixation of tissue |
US20060228448A1 (en) * | 2005-04-11 | 2006-10-12 | The Iams Company | Pet food compositions comprising two components |
US20060228459A1 (en) | 2005-04-11 | 2006-10-12 | The Iams Company | Compositions comprising a cocoa butter component and an animal-derived fat component |
US20100233312A9 (en) * | 2005-04-11 | 2010-09-16 | The Procter & Gamble Company | Compositions comprising probiotic and sweetener components |
RU2379944C2 (ru) | 2005-05-11 | 2010-01-27 | Хилл`С Пет Ньютришн, Инк. | Улучшающая вкус композиция для кормления собак, способ ее получения, продукт способа, набор, способ усиления вкуса корма для собак и способ увеличения приема или частоты приема корма |
WO2006124675A2 (en) | 2005-05-13 | 2006-11-23 | Hill's Pet Nutrition, Inc. | Dry food compositions having enhanced palatability |
RU2372794C2 (ru) | 2005-05-20 | 2009-11-20 | Хилл`С Пет Ньютришн, Инк. | Способы укрепления здоровья или общего состояния взрослых животных |
US9480275B2 (en) * | 2005-05-20 | 2016-11-01 | Mars Incorporated | Coated pet food products |
AU2006253006B8 (en) | 2005-05-31 | 2011-09-15 | Alimentary Health Ltd | Feline probiotic Lactobacilli |
AU2006253007B2 (en) | 2005-05-31 | 2012-12-20 | Alimentary Health Ltd | Feline probiotic Bifidobacteria |
US20080280274A1 (en) | 2005-06-01 | 2008-11-13 | Kim Gene Friesen | Methods For Enhancing Palatability of Compositions for Animal Consumption |
AT501919B1 (de) | 2005-06-14 | 2008-09-15 | Erber Ag | Probiotischer, gesundheits- bzw. leistungsfördernder futtermittel- und/oder trinkwasserzusatz für tiere sowie seine verwendung |
US20070009577A1 (en) * | 2005-07-05 | 2007-01-11 | Mankovitz Roy J | Probiotic compositions and methods |
US20070149466A1 (en) | 2005-07-07 | 2007-06-28 | Michael Milburn | Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders |
BRPI0613000A2 (pt) | 2005-07-14 | 2012-12-04 | Hills Pet Nutrition Inc | método para aumentar a longevidade de um animal, artigo de fabricação, kit, e, meio de comunicação de informação acerca de ou instruções para a administração a um animal velho de uma composição |
US20070122531A1 (en) * | 2005-09-01 | 2007-05-31 | Wellmark International | Methods for Selecting a Pet-Appropriate Product |
US8865197B2 (en) * | 2005-09-06 | 2014-10-21 | Israel Oceanographic And Limnological Research Ltd. | Food formulation for aquatic animals with integrated targeted delivery of bioactive agents |
GB0519164D0 (en) * | 2005-09-20 | 2005-10-26 | Mars Inc | Composition |
RU2388320C2 (ru) | 2005-09-30 | 2010-05-10 | Хилл'С Пет Ньютришн, Инк. | Способы увеличения срока хранения пищевых композиций, содержащих полиненасыщенные жирные кислоты |
CA2623214C (en) | 2005-09-30 | 2011-07-26 | Hill's Pet Nutrition, Inc. | Methods for extending the shelf-life of food compositions containing polyunsaturated fatty acids |
JP4198728B2 (ja) | 2005-09-30 | 2008-12-17 | 株式会社グローバルエンジニアリング | 動物用免疫活性調整剤、及びその調整剤を含有する動物用飼料 |
US20070280964A1 (en) | 2005-10-06 | 2007-12-06 | Ruth Knorr | Compositions and methods useful for modulating immunity, enhancing vaccine efficacy, decreasing morbidity associated with chronic FHV-1 infections, and preventing or treating conjunctivitis |
US20070098744A1 (en) * | 2005-10-06 | 2007-05-03 | Nestec S.A. | Probiotic enterococci for improved immunity |
US20070082107A1 (en) * | 2005-10-07 | 2007-04-12 | Aimutis William R Jr | Compositions and methods for reducing food intake and controlling weight |
BRPI0617479A2 (pt) | 2005-10-19 | 2016-11-08 | Hills Pet Nutrition Inc | método e composição útil para manter ou melhorar a saúde gastrintestiinal de um animal, kit, meio para comunicação de informações ou instruções, e, uso de uma composição |
US7647098B2 (en) * | 2005-10-31 | 2010-01-12 | New York University | System and method for prediction of cognitive decline |
CN101299926B (zh) | 2005-11-04 | 2014-03-05 | 希尔氏宠物营养品公司 | 改善粪便质量的方法和组合物 |
FR2893628B1 (fr) | 2005-11-18 | 2008-05-16 | Expanscience Laboratoires Sa | Procede d'obtention d'une huile d'avocat raffinee riche en triglycerides et huile susceptible d'etre obtenue par un tel procede |
US8524304B2 (en) * | 2005-11-23 | 2013-09-03 | The Coca-Cola Company | High-potency sweetener composition with probiotics/prebiotics and compositions sweetened therewith |
WO2007060539A2 (en) | 2005-11-28 | 2007-05-31 | Jorrocks Pty Ltd. | Methods for preparation of animal feeds |
RU2390342C2 (ru) * | 2005-12-02 | 2010-05-27 | Хилл`С Пет Ньютришн, Инк. | Способы изменения качества стула и/или частоты стула |
ATE541469T1 (de) * | 2005-12-29 | 2012-02-15 | Hills Pet Nutrition Inc | Verfahren zum modifizieren der darmflora bei tieren |
DE102006001554A1 (de) | 2006-01-05 | 2007-07-12 | Ipc Process-Center Gmbh & Co. | Micropellets für die Herstellung von Tiernahrungspellets |
DE102006001553A1 (de) | 2006-01-05 | 2007-07-19 | Ipc Process-Center Gmbh & Co. | Teilchen mit darin enthaltener empfindlicher Komponente |
EP1993384A2 (en) * | 2006-01-11 | 2008-11-26 | Attune Foods | Probiotic food, process for its preparation and dietary regimen |
US20070166295A1 (en) * | 2006-01-13 | 2007-07-19 | Vet Solutions L.P. | Anti-Diarrhea Preparations for Small Domestic Animals |
US8057840B2 (en) * | 2006-01-25 | 2011-11-15 | Tate & Lyle Ingredients Americas Llc | Food products comprising a slowly digestible or digestion resistant carbohydrate composition |
MX2008009574A (es) | 2006-02-01 | 2008-09-04 | Nestec Sa | Sistema y metodos nutricionales para aumentar la longevidad. |
PL1986669T3 (pl) | 2006-02-15 | 2012-09-28 | Nestec Sa | Zastosowanie Bifidobacterium longum do zapobiegania i leczenia zapalenia |
US7960605B2 (en) | 2006-03-17 | 2011-06-14 | BioMaker Pharmaceuticals, Inc. | Methods for testing for caloric restriction (CR) mimetics |
PL2004201T3 (pl) | 2006-03-29 | 2019-02-28 | Nestec S.A. | Suplementy diety zawierające probiotyki |
US20070231414A1 (en) | 2006-03-29 | 2007-10-04 | Kaneka Corporation | Composition having bone resorption inhibition-related effect and method for inhibiting bone resorption |
US7931930B2 (en) * | 2006-05-19 | 2011-04-26 | Delavau Llc | Delivery of active agents using a chocolate vehicle |
WO2007137808A1 (en) | 2006-05-29 | 2007-12-06 | University College Dublin, National University Of Ireland, Dublin | Compositions comprising oligosaccharides for treating prion disease |
EA200870545A1 (ru) * | 2006-05-31 | 2009-12-30 | Глэксо Груп Лимитед | Новые гетероциклические соединения |
JP2007330180A (ja) | 2006-06-16 | 2007-12-27 | Iris Ohyama Inc | ペットフード及びその製造方法 |
WO2008019887A2 (en) | 2006-08-18 | 2008-02-21 | Organobalance Gmbh | Probiotic microorganisms for the reduction of manure odor |
US20080053490A1 (en) * | 2006-09-01 | 2008-03-06 | Bausch & Lomb Incorporated | Method for hydrating a contact lens |
US20080107699A1 (en) * | 2006-10-25 | 2008-05-08 | Mark Spigelman | Method of using topical probiotics for the inhibition of surface contamination by a pathogenic microorganism and composition therefor |
EP2124608A2 (en) | 2007-01-19 | 2009-12-02 | The Iams Company | Composition and method of stabilized sensitive ingredient |
US20090175838A1 (en) | 2007-01-26 | 2009-07-09 | Newell Rogers M Karen | Methods of modulating immune function |
JP5799299B2 (ja) | 2007-02-01 | 2015-10-21 | ザ・アイムス・カンパニーThe Iams Company | ブドウ糖代謝拮抗物質、アボカド又はアボカド抽出物を使用する、哺乳動物における炎症及びストレスの低下方法 |
RU2429853C2 (ru) | 2007-02-01 | 2011-09-27 | Дзе Иамс Компани | Способ уменьшения воспаления и окислительного стресса у млекопитающих |
RU2407401C2 (ru) | 2007-02-13 | 2010-12-27 | Общество С Ограниченной Ответственностью "Марс" | Способ кормления собак |
CN101636173A (zh) * | 2007-03-27 | 2010-01-27 | 宝洁公司 | 施用益生菌剂的方法及试剂盒 |
BRPI0812647A2 (pt) | 2007-07-13 | 2014-09-30 | Unilever Nv | "composição e método para produzir a composição" |
IL199781A0 (en) | 2009-07-09 | 2010-05-17 | Yohai Zorea | Heat resistant probiotic compositions and healthy food comprising them |
TW200936180A (en) | 2007-11-27 | 2009-09-01 | Intervet Int Bv | Carrier particle for a microorganism or subunit thereof, pharmaceutical composition comprising such particles, method for preparation of this composition and its use in the treatment of animals |
US20100028483A1 (en) | 2008-05-09 | 2010-02-04 | Mars Incorporated | Solid edible product for a pet |
US9771199B2 (en) | 2008-07-07 | 2017-09-26 | Mars, Incorporated | Probiotic supplement, process for making, and packaging |
USD605527S1 (en) | 2008-07-07 | 2009-12-08 | The Procter & Gamble Company | Pet food supplement package |
USD606278S1 (en) | 2008-07-07 | 2009-12-22 | The Procter & Gamble Company | Pet food supplement |
US9232813B2 (en) | 2008-07-07 | 2016-01-12 | The Iams Company | Probiotic supplement, process for making, and packaging |
MX2011002735A (es) | 2008-09-11 | 2011-04-12 | Iams Company | Alimento granulado para animales que tiene un nucleo basado en proteinas y metodos relacionados. |
US10104903B2 (en) | 2009-07-31 | 2018-10-23 | Mars, Incorporated | Animal food and its appearance |
US8691303B2 (en) | 2009-07-31 | 2014-04-08 | The Iams Company | Dusted animal food |
US9210945B2 (en) | 2009-07-31 | 2015-12-15 | The Iams Company | Animal food having low water activity |
WO2011069051A1 (en) | 2009-12-04 | 2011-06-09 | Caliper Life Sciences, Inc. | Method of using dopamine reuptake inhibitors and their analogs for treating diabetes symptoms and delaying or preventing diabetes-associated pathologic conditions |
EP2384647A1 (en) | 2010-05-07 | 2011-11-09 | Adexgo Ltd. | Feed additive compositions and method for the production thereof |
US20120115798A1 (en) | 2010-11-04 | 2012-05-10 | Stefan Patrick Massimino | Method for improving the immunity of a companion animal |
US20120156330A1 (en) | 2010-12-16 | 2012-06-21 | Nakhasi Dilip K | Low sodium margarine spread enriched with probiotics field |
FR2969496B1 (fr) | 2010-12-22 | 2013-11-08 | Expanscience Lab | Extrait de pulpe et/ou de peau d'avocat riche en polyphenols et compositions cosmetiques, dermatologiques et nutraceutiques le comprenant |
US20120283197A1 (en) | 2011-05-02 | 2012-11-08 | Ashok Premchand Luhadiya | Compositions Comprising a Glucose Anti-Metabolite, BHA, and/or BHT |
US20120282373A1 (en) | 2011-05-02 | 2012-11-08 | Ashok Premchand Luhadiya | Compositions Comprising a Glucose Anti-Metabolite and Selenium |
US20130295227A1 (en) | 2012-05-01 | 2013-11-07 | Robbert H. ter Haar | Composition Comprising a Sensitive Ingredient |
CA2879784C (en) | 2012-07-25 | 2020-09-15 | Agrofresh Inc. | Methods of handling avocados and system |
US20140348986A1 (en) | 2013-05-23 | 2014-11-27 | The Iams Company | Avocado Processing |
PL2805721T3 (pl) | 2013-05-23 | 2019-01-31 | Iams Europe B V | Naśladowanie metabolicznego wpływu restrykcji kalorycznej przez podawanie antymetabolitów glukozy dla zwiększenia pozytywnej odpowiedzi u ssaka |
US20140349002A1 (en) | 2013-05-23 | 2014-11-27 | The Iams Company | Ingestible Compositions Containing Criollo Avocado Component |
EP3068238A4 (en) | 2013-11-11 | 2017-07-12 | The Iams Company | Processes for preparing a carbohydrate extract comprising mannoheptulose and compositions comprising same |
-
2008
- 2008-07-07 US US12/168,400 patent/US9771199B2/en active Active
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- 2009-07-02 BR BRPI0915566A patent/BRPI0915566B1/pt active IP Right Grant
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CN101155518A (zh) * | 2005-04-11 | 2008-04-02 | 爱默思公司 | 包含两种组分的宠物食物组合物 |
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AR072705A1 (es) | 2010-09-15 |
JP5650111B2 (ja) | 2015-01-07 |
JP2011527194A (ja) | 2011-10-27 |
BRPI0915566B1 (pt) | 2020-01-28 |
US10709156B2 (en) | 2020-07-14 |
WO2010005855A1 (en) | 2010-01-14 |
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RU2503247C2 (ru) | 2014-01-10 |
CN102105068A (zh) | 2011-06-22 |
US20100203225A1 (en) | 2010-08-12 |
BRPI0915566A2 (pt) | 2017-10-10 |
EP2299840B1 (en) | 2020-09-09 |
MX2011000283A (es) | 2011-02-25 |
CA2730066A1 (en) | 2010-01-14 |
US9771199B2 (en) | 2017-09-26 |
US20100003368A1 (en) | 2010-01-07 |
BRPI0915566A8 (pt) | 2018-04-17 |
RU2010154015A (ru) | 2012-07-20 |
AU2009268805A1 (en) | 2010-01-14 |
CA2730066C (en) | 2014-02-04 |
AU2009268805B2 (en) | 2015-01-22 |
EP2299840A1 (en) | 2011-03-30 |
US20170143008A1 (en) | 2017-05-25 |
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