CH645890A5 - Monacolin k, seine herstellung und dieses enthaltendes antihypercholesterinaemisches mittel. - Google Patents

Monacolin k, seine herstellung und dieses enthaltendes antihypercholesterinaemisches mittel. Download PDF

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Publication number
CH645890A5
CH645890A5 CH136680A CH136680A CH645890A5 CH 645890 A5 CH645890 A5 CH 645890A5 CH 136680 A CH136680 A CH 136680A CH 136680 A CH136680 A CH 136680A CH 645890 A5 CH645890 A5 CH 645890A5
Authority
CH
Switzerland
Prior art keywords
monacolin
strain
microorganism
production
monascus
Prior art date
Application number
CH136680A
Other languages
German (de)
English (en)
Inventor
Akira Endo
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of CH645890A5 publication Critical patent/CH645890A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CH136680A 1979-02-20 1980-02-20 Monacolin k, seine herstellung und dieses enthaltendes antihypercholesterinaemisches mittel. CH645890A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP54017856A JPS5925599B2 (ja) 1979-02-20 1979-02-20 新生理活性物質モナコリンｋおよびその製造法

Publications (1)

Publication Number Publication Date
CH645890A5 true CH645890A5 (de) 1984-10-31

Family

ID=11955290

Family Applications (1)

Application Number Title Priority Date Filing Date
CH136680A CH645890A5 (de) 1979-02-20 1980-02-20 Monacolin k, seine herstellung und dieses enthaltendes antihypercholesterinaemisches mittel.

Country Status (27)

Country Link
JP (1) JPS5925599B2 (da)
KR (1) KR830002801B1 (da)
AT (1) AT373915B (da)
AU (1) AU532626B2 (da)
BE (1) BE881825A (da)
CA (1) CA1129794A (da)
CH (1) CH645890A5 (da)
DD (1) DD154494A5 (da)
DE (2) DE3051175C2 (da)
DK (2) DK149095C (da)
ES (1) ES8103171A1 (da)
FI (1) FI66427C (da)
FR (1) FR2449685B1 (da)
GB (1) GB2046737B (da)
HU (1) HU182069B (da)
IE (1) IE49743B1 (da)
IT (1) IT1175260B (da)
MX (1) MX6314E (da)
NL (1) NL191540C (da)
NO (1) NO153974C (da)
NZ (1) NZ192919A (da)
PH (1) PH15145A (da)
PL (1) PL124304B1 (da)
SE (1) SE453301B (da)
SG (1) SG6784G (da)
SU (2) SU1158048A3 (da)
ZA (1) ZA80962B (da)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
JPS5621594A (en) * 1979-07-27 1981-02-28 Sankyo Co Ltd Mb-530b carboxylic acid metal salt and its preparation
PT72394B (en) * 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
JPH0692381B2 (ja) * 1980-03-31 1994-11-16 三共株式会社 Ｍｂ−５３０ａ誘導体
JPS56142236A (en) 1980-04-08 1981-11-06 Sankyo Co Ltd Ml-236a and mb-530a derivative
DK149080C (da) * 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
JPS5835144A (ja) * 1981-08-27 1983-03-01 Sankyo Co Ltd Ｍｂ−５３０ｂ誘導体およびその製造法
US4782084A (en) * 1987-06-29 1988-11-01 Merck & Co., Inc. HMG-COA reductase inhibitors
US4997848A (en) * 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
CA2062023A1 (en) * 1992-02-10 1993-08-11 Jagroop S. Dahiya Novel fungal strains and use thereof in antibiotic production
JPH07504568A (ja) * 1992-03-04 1995-05-25 藤沢薬品工業株式会社 ＨＭＧ−ＣｏＡレダクターゼ阻害物質としてのテトラリン誘導体
NZ247617A (en) 1992-05-15 1995-07-26 Sankyo Co Octahydronaphthalene oxime derivatives and pharmaceutical compositions
US6812007B1 (en) * 1992-11-04 2004-11-02 Keri Vilmos Process for the isolation and purification of mevinolin
HU210867B (en) * 1992-11-04 1995-10-30 Biogal Gyogyszergyar Method for extraction and purification of mevinolin from culture medium
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US5409820A (en) * 1993-08-06 1995-04-25 Apotex, Inc. Process for the production of lovastatin using Coniothyrium fuckelii
US6046022A (en) 1996-09-30 2000-04-04 Peking University Methods and compositions employing red rice fermentation products
US7238348B2 (en) 1996-09-30 2007-07-03 Beijing Peking University Wbl Corporation Ltd. Method of treatment of osteoporosis with compositions of red rice fermentation products
NZ500870A (en) 1998-03-20 2002-03-01 Biogal Gyogyszergyar Metabolic controlled fermentation process for preparing mevinolin (lovastatin)
AU3654301A (en) 2000-02-24 2001-09-03 Biogal Gyogyszergyar Method of purifying a fermentation broth
HUP0301214A2 (hu) 2000-03-03 2003-08-28 Plus Chemicals S.A. Tisztítási eljárás csökkentett dimer szennyező tartalmú lovastatin és simvastatin előállítására
KR20010095780A (ko) * 2000-04-12 2001-11-07 나가오카 마사시 배아 홍국
IN192861B (da) 2000-06-30 2004-05-22 Ranbaxy Lab Ltd
WO2002064809A2 (en) * 2001-02-09 2002-08-22 Unilever N.V. Process for the preparation of one or more statins by fermentation
KR100379075B1 (en) 2002-03-07 2003-04-08 Jinis Biopharmaceuticals Co Method for producing low cholesterol animal food product and food product therefrom
KR20020093147A (ko) * 2002-05-30 2002-12-13 지니스생명공학 주식회사 성인병 예방 및 치료 보조제
KR100710500B1 (ko) 2005-05-18 2007-04-24 고려대학교 산학협력단 홍국균을 이용한 모나콜린 ｋ 생산방법
EP2373609B1 (en) 2008-12-19 2013-10-16 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
RO128803A0 (ro) 2012-10-12 2013-09-30 Ion Gigel Fulga Compoziţie pentru tratamentul sau prevenirea dislipidemiilor
CN110331151A (zh) * 2019-04-11 2019-10-15 北京工商大学 紫色红曲菌mokH基因过表达菌株的构建方法
CN111297938A (zh) * 2020-03-11 2020-06-19 北京康立生医药技术开发有限公司 一种辅助降血脂组合物中洛伐他汀的检测方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (da) * 1974-06-07 1981-03-18
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
AU535944B2 (en) * 1979-06-15 1984-04-12 Merck & Co., Inc. Hypocholestermic fermentation products from aspergillus

Also Published As

Publication number Publication date
SE453301B (sv) 1988-01-25
DE3051175C2 (da) 1989-12-21
IT8067262A0 (it) 1980-02-20
NZ192919A (en) 1984-07-06
GB2046737B (en) 1983-01-12
ZA80962B (en) 1981-03-25
KR830002801B1 (ko) 1983-12-16
HU182069B (en) 1983-12-28
SG6784G (en) 1985-02-08
NO153974C (no) 1986-06-25
SU1158048A3 (ru) 1985-05-23
SE8001339L (sv) 1980-08-21
PH15145A (en) 1982-08-24
NO153974B (no) 1986-03-17
AT373915B (de) 1984-03-12
DD154494A5 (de) 1982-03-24
BE881825A (fr) 1980-08-20
DE3006216A1 (de) 1980-09-04
JPS5925599B2 (ja) 1984-06-19
ES488796A0 (es) 1981-02-16
FI800506A (fi) 1980-08-21
MX6314E (es) 1985-04-01
JPS55111790A (en) 1980-08-28
PL124304B1 (en) 1983-01-31
DE3006216C2 (de) 1985-10-31
DK73080A (da) 1980-08-21
FI66427C (fi) 1984-10-10
FR2449685A1 (fr) 1980-09-19
AU5567380A (en) 1980-08-28
FR2449685B1 (fr) 1985-06-28
IT1175260B (it) 1987-07-01
FI66427B (fi) 1984-06-29
PL222120A1 (da) 1980-10-20
DK149095C (da) 1986-06-16
AU532626B2 (en) 1983-10-06
DK149095B (da) 1986-01-20
ATA92980A (de) 1983-07-15
DK21889A (da) 1989-01-18
SU969702A1 (ru) 1982-10-30
CA1129794A (en) 1982-08-17
DK21889D0 (da) 1989-01-18
GB2046737A (en) 1980-11-19
NL191540C (nl) 1995-09-04
NL191540B (nl) 1995-05-01
ES8103171A1 (es) 1981-02-16
KR830002030A (ko) 1983-05-21
NL8001041A (nl) 1980-08-22
NO800451L (no) 1980-08-21
IE800321L (en) 1980-08-20
IE49743B1 (en) 1985-12-11

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PL Patent ceased