IE800321L - An antihypercholesteraemic agent, monacolin k - Google Patents
An antihypercholesteraemic agent, monacolin kInfo
- Publication number
- IE800321L IE800321L IE800321A IE32180A IE800321L IE 800321 L IE800321 L IE 800321L IE 800321 A IE800321 A IE 800321A IE 32180 A IE32180 A IE 32180A IE 800321 L IE800321 L IE 800321L
- Authority
- IE
- Ireland
- Prior art keywords
- substance
- monacolin
- acetone
- c24h36o5
- dichloromethane
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
Abstract
PURPOSE:To produce blood cholesterol lowering drug by cultivating a monacolin K-producing strain of the microoganism Monascus. CONSTITUTION:Monascus ruber No.1005 (FERM-P4822) strain is cultivated, and the produced physiologically active substance monacolin K is isolated. The substance monacolin K is neutral and colorless crystal. The substance has molecular formula C24H36O5(MW=404). The elemental analysis for C24H36O5:C71.56%; H8.85%; O 19.59%. The substance shows a melting point of 157-159 deg.C and an optical rotation of [alpha]D<25>=+307.6(c=1, in methanol). The substance is soluble in alcohol, acetone, ethyl acetate, chloroform and benzene; and insoluble in hexane and petroleum ether. In chromatographic studies, silica gel thin-layer chromatography employing developer consisting of dichloromethane and acetone in a ratio of dichloromethane to acetone of 4:1 shows a single spot of Rf=0.47.
[JP55111790A]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP54017856A JPS5925599B2 (en) | 1979-02-20 | 1979-02-20 | New physiologically active substance monacolin K and its production method |
Publications (2)
Publication Number | Publication Date |
---|---|
IE800321L true IE800321L (en) | 1980-08-20 |
IE49743B1 IE49743B1 (en) | 1985-12-11 |
Family
ID=11955290
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE321/80A IE49743B1 (en) | 1979-02-20 | 1980-02-19 | Antihypercholesteraemic agent,monacolin k,and its preparation |
Country Status (27)
Country | Link |
---|---|
JP (1) | JPS5925599B2 (en) |
KR (1) | KR830002801B1 (en) |
AT (1) | AT373915B (en) |
AU (1) | AU532626B2 (en) |
BE (1) | BE881825A (en) |
CA (1) | CA1129794A (en) |
CH (1) | CH645890A5 (en) |
DD (1) | DD154494A5 (en) |
DE (2) | DE3051175C2 (en) |
DK (2) | DK149095C (en) |
ES (1) | ES8103171A1 (en) |
FI (1) | FI66427C (en) |
FR (1) | FR2449685B1 (en) |
GB (1) | GB2046737B (en) |
HU (1) | HU182069B (en) |
IE (1) | IE49743B1 (en) |
IT (1) | IT1175260B (en) |
MX (1) | MX6314E (en) |
NL (1) | NL191540C (en) |
NO (1) | NO153974C (en) |
NZ (1) | NZ192919A (en) |
PH (1) | PH15145A (en) |
PL (1) | PL124304B1 (en) |
SE (1) | SE453301B (en) |
SG (1) | SG6784G (en) |
SU (2) | SU1158048A3 (en) |
ZA (1) | ZA80962B (en) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55150898A (en) * | 1979-05-11 | 1980-11-25 | Sankyo Co Ltd | Preparation of a new physiologically active substance mb-530b |
US4231938A (en) * | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
JPS5621594A (en) * | 1979-07-27 | 1981-02-28 | Sankyo Co Ltd | Mb-530b carboxylic acid metal salt and its preparation |
PT72394B (en) * | 1980-02-04 | 1982-09-06 | Merck & Co Inc | Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics |
AU548996B2 (en) * | 1980-02-04 | 1986-01-09 | Merck & Co., Inc. | Tetrahydro-2h-pyran-2-one derivatives |
JPH0692381B2 (en) * | 1980-03-31 | 1994-11-16 | 三共株式会社 | MB-530A derivative |
JPS56142236A (en) | 1980-04-08 | 1981-11-06 | Sankyo Co Ltd | Ml-236a and mb-530a derivative |
DK149080C (en) * | 1980-06-06 | 1986-07-28 | Sankyo Co | METHOD FOR PREPARING ML-236B CARBOXYLIC ACID DERIVATIVES |
JPS5835144A (en) * | 1981-08-27 | 1983-03-01 | Sankyo Co Ltd | Mb-530b derivative and its preparation |
US4782084A (en) * | 1987-06-29 | 1988-11-01 | Merck & Co., Inc. | HMG-COA reductase inhibitors |
US4997848A (en) * | 1987-10-27 | 1991-03-05 | Sankyo Company, Limited | Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition |
CA2062023A1 (en) | 1992-02-10 | 1993-08-11 | Jagroop S. Dahiya | Novel fungal strains and use thereof in antibiotic production |
JPH07504568A (en) * | 1992-03-04 | 1995-05-25 | 藤沢薬品工業株式会社 | Tetralin derivatives as HMG-CoA reductase inhibitors |
NZ247617A (en) | 1992-05-15 | 1995-07-26 | Sankyo Co | Octahydronaphthalene oxime derivatives and pharmaceutical compositions |
HU210867B (en) * | 1992-11-04 | 1995-10-30 | Biogal Gyogyszergyar | Method for extraction and purification of mevinolin from culture medium |
US6812007B1 (en) * | 1992-11-04 | 2004-11-02 | Keri Vilmos | Process for the isolation and purification of mevinolin |
SI9300303A (en) * | 1993-06-08 | 1994-12-31 | Krka Tovarna Zdravil | Process for isolation of hypolipemic effective substance |
US5409820A (en) * | 1993-08-06 | 1995-04-25 | Apotex, Inc. | Process for the production of lovastatin using Coniothyrium fuckelii |
US7238348B2 (en) | 1996-09-30 | 2007-07-03 | Beijing Peking University Wbl Corporation Ltd. | Method of treatment of osteoporosis with compositions of red rice fermentation products |
US6046022A (en) | 1996-09-30 | 2000-04-04 | Peking University | Methods and compositions employing red rice fermentation products |
US6500651B1 (en) | 1998-03-20 | 2002-12-31 | Biogal Gyogyszergyar Rt. | Metabolic controlled fermentation procedure for the manufacture of lovastatin hydroxy acid |
US6387258B1 (en) | 2000-02-24 | 2002-05-14 | Biogal Gyogyszergyar Rt. | Method of purifying statins from a fermentation broth |
TR200403001T3 (en) | 2000-03-03 | 2005-02-21 | Plus Chemical, S.A. | A process for the treatment of lovastatin and simvastatin with reduced dimeric impurity levels |
KR20010095780A (en) * | 2000-04-12 | 2001-11-07 | 나가오카 마사시 | Embryo monascus |
IN192861B (en) | 2000-06-30 | 2004-05-22 | Ranbaxy Lab Ltd | |
CN1273608C (en) * | 2001-02-09 | 2006-09-06 | 荷兰联合利华有限公司 | Process for preparation of one or more statins by fermentation |
KR100379075B1 (en) | 2002-03-07 | 2003-04-08 | Jinis Biopharmaceuticals Co | Method for producing low cholesterol animal food product and food product therefrom |
KR20020093147A (en) * | 2002-05-30 | 2002-12-13 | 지니스생명공학 주식회사 | Preventive and Dietary Supplement for adult chronic disease |
KR100710500B1 (en) | 2005-05-18 | 2007-04-24 | 고려대학교 산학협력단 | Method for producing Monacolin K using Monascus sp |
EP2373609B1 (en) | 2008-12-19 | 2013-10-16 | KRKA, D.D., Novo Mesto | Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates |
EP2327682A1 (en) | 2009-10-29 | 2011-06-01 | KRKA, D.D., Novo Mesto | Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates |
RO128803A0 (en) | 2012-10-12 | 2013-09-30 | Ion Gigel Fulga | Composition for the treatment or prevention of dyslipidemias |
CN110331151A (en) * | 2019-04-11 | 2019-10-15 | 北京工商大学 | The construction method of purple Monascus mokH gene overexpression bacterial strain |
CN111297938A (en) * | 2020-03-11 | 2020-06-19 | 北京康立生医药技术开发有限公司 | Method for detecting lovastatin in composition for assisting in reducing blood fat |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5612114B2 (en) * | 1974-06-07 | 1981-03-18 | ||
JPS55150898A (en) * | 1979-05-11 | 1980-11-25 | Sankyo Co Ltd | Preparation of a new physiologically active substance mb-530b |
GR69216B (en) * | 1979-06-15 | 1982-05-07 | Merck & Co Inc |
-
1979
- 1979-02-20 JP JP54017856A patent/JPS5925599B2/en not_active Expired
-
1980
- 1980-02-19 IE IE321/80A patent/IE49743B1/en not_active IP Right Cessation
- 1980-02-19 KR KR1019800000654A patent/KR830002801B1/en active
- 1980-02-19 AU AU55673/80A patent/AU532626B2/en not_active Expired
- 1980-02-19 CA CA345,983A patent/CA1129794A/en not_active Expired
- 1980-02-20 BE BE0/199476A patent/BE881825A/en not_active IP Right Cessation
- 1980-02-20 DK DK73080A patent/DK149095C/en not_active IP Right Cessation
- 1980-02-20 HU HU80397A patent/HU182069B/en unknown
- 1980-02-20 DE DE3051175A patent/DE3051175C2/de not_active Expired
- 1980-02-20 PL PL1980222120A patent/PL124304B1/en unknown
- 1980-02-20 MX MX808652U patent/MX6314E/en unknown
- 1980-02-20 GB GB8005748A patent/GB2046737B/en not_active Expired
- 1980-02-20 NZ NZ192919A patent/NZ192919A/en unknown
- 1980-02-20 AT AT0092980A patent/AT373915B/en not_active IP Right Cessation
- 1980-02-20 IT IT67262/80A patent/IT1175260B/en active
- 1980-02-20 ZA ZA00800962A patent/ZA80962B/en unknown
- 1980-02-20 CH CH136680A patent/CH645890A5/en not_active IP Right Cessation
- 1980-02-20 DD DD80219159A patent/DD154494A5/en unknown
- 1980-02-20 FR FR8003662A patent/FR2449685B1/en not_active Expired
- 1980-02-20 ES ES488796A patent/ES8103171A1/en not_active Expired
- 1980-02-20 DE DE3006216A patent/DE3006216C2/en not_active Expired
- 1980-02-20 NO NO800451A patent/NO153974C/en unknown
- 1980-02-20 PH PH23668A patent/PH15145A/en unknown
- 1980-02-20 SU SU802887300A patent/SU1158048A3/en active
- 1980-02-20 NL NL8001041A patent/NL191540C/en not_active IP Right Cessation
- 1980-02-20 FI FI800506A patent/FI66427C/en not_active IP Right Cessation
- 1980-02-20 SE SE8001339A patent/SE453301B/en not_active IP Right Cessation
- 1980-09-12 SU SU802977031A patent/SU969702A1/en active
-
1984
- 1984-01-24 SG SG67/84A patent/SG6784G/en unknown
-
1989
- 1989-01-18 DK DK021889A patent/DK21889A/en not_active Application Discontinuation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK9A | Patent expired |