FR2449685A1 - ANTIHYPERCHOLESTEROLEMIC AGENT PREPARED BY CULTURE OF MICROORGANISMS OF THE GENUS MONASCUS AND METHOD FOR PREPARING THE SAME - Google Patents

ANTIHYPERCHOLESTEROLEMIC AGENT PREPARED BY CULTURE OF MICROORGANISMS OF THE GENUS MONASCUS AND METHOD FOR PREPARING THE SAME

Info

Publication number
FR2449685A1
FR2449685A1 FR8003662A FR8003662A FR2449685A1 FR 2449685 A1 FR2449685 A1 FR 2449685A1 FR 8003662 A FR8003662 A FR 8003662A FR 8003662 A FR8003662 A FR 8003662A FR 2449685 A1 FR2449685 A1 FR 2449685A1
Authority
FR
France
Prior art keywords
microorganisms
culture
preparing
same
agent prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8003662A
Other languages
French (fr)
Other versions
FR2449685B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of FR2449685A1 publication Critical patent/FR2449685A1/en
Application granted granted Critical
Publication of FR2449685B1 publication Critical patent/FR2449685B1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

L'INVENTION A POUR OBJET UN NOUVEAU COMPOSE, DESIGNE MONACOLINE K, DE FORMULE: (CF DESSIN DANS BOPI) AYANT NOTAMMENT UNE PRECIEUSE ACTIVITE ANTIHYPERCHOLESTEROLEMIQUE. ON PEUT LE PREPARER EN CULTIVANT DES MICROORGANISMES APPROPRIES DU GENRE MONASCUS, EN PARTICULIER LA SOUCHE MONASCUS RUBER 1005 (FERM 4822).THE SUBJECT OF THE INVENTION IS A NEW COMPOUND, DESIGNATED MONACOLIN K, OF THE FORMULA: (CF DESIGN IN BOPI) HAVING IN PARTICULAR A PRECIOUS ANTIHYPERCHOLESTEROLEMIC ACTIVITY. IT CAN BE PREPARED BY GROWING APPROPRIATE MICROORGANISMS OF THE GENUS MONASCUS, IN PARTICULAR MONASCUS RUBER 1005 (FERM 4822).

FR8003662A 1979-02-20 1980-02-20 ANTIHYPERCHOLESTEROLEMIC AGENT PREPARED BY CULTURE OF MICROORGANISMS OF THE MONASCUS GENUS AND METHOD FOR PREPARING THE SAME Expired FR2449685B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP54017856A JPS5925599B2 (en) 1979-02-20 1979-02-20 New physiologically active substance monacolin K and its production method

Publications (2)

Publication Number Publication Date
FR2449685A1 true FR2449685A1 (en) 1980-09-19
FR2449685B1 FR2449685B1 (en) 1985-06-28

Family

ID=11955290

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8003662A Expired FR2449685B1 (en) 1979-02-20 1980-02-20 ANTIHYPERCHOLESTEROLEMIC AGENT PREPARED BY CULTURE OF MICROORGANISMS OF THE MONASCUS GENUS AND METHOD FOR PREPARING THE SAME

Country Status (27)

Country Link
JP (1) JPS5925599B2 (en)
KR (1) KR830002801B1 (en)
AT (1) AT373915B (en)
AU (1) AU532626B2 (en)
BE (1) BE881825A (en)
CA (1) CA1129794A (en)
CH (1) CH645890A5 (en)
DD (1) DD154494A5 (en)
DE (2) DE3051175C2 (en)
DK (2) DK149095C (en)
ES (1) ES488796A0 (en)
FI (1) FI66427C (en)
FR (1) FR2449685B1 (en)
GB (1) GB2046737B (en)
HU (1) HU182069B (en)
IE (1) IE49743B1 (en)
IT (1) IT1175260B (en)
MX (1) MX6314E (en)
NL (1) NL191540C (en)
NO (1) NO153974C (en)
NZ (1) NZ192919A (en)
PH (1) PH15145A (en)
PL (1) PL124304B1 (en)
SE (1) SE453301B (en)
SG (1) SG6784G (en)
SU (2) SU1158048A3 (en)
ZA (1) ZA80962B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2456141A1 (en) * 1979-05-11 1980-12-05 Sankyo Co PROCESS FOR THE PREPARATION OF MONACOLIN K
FR2479222A1 (en) * 1980-03-31 1981-10-02 Sankyo Co COMPOUND DERIVATIVES OF MONACOLIN K TYPE HAVING INHIBITORY ACTIVITY ON CHOLESTEROL BIOSYNTHESIS, PREPARATION METHOD AND THERAPEUTIC USE THEREOF
EP0074222A1 (en) * 1981-08-27 1983-03-16 Sankyo Company Limited MB-530B derivatives, their preparation and pharmaceutical compositions containing them
WO1993017991A1 (en) * 1992-03-04 1993-09-16 Fujisawa Pharmaceutical Co., Ltd. TETRALIN DERIVATIVES AS HMG-CoA REDUCTASE INHIBITORS

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
JPS5621594A (en) * 1979-07-27 1981-02-28 Sankyo Co Ltd Mb-530b carboxylic acid metal salt and its preparation
PT72394B (en) * 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
JPS56142236A (en) 1980-04-08 1981-11-06 Sankyo Co Ltd Ml-236a and mb-530a derivative
DK149080C (en) * 1980-06-06 1986-07-28 Sankyo Co METHOD FOR PREPARING ML-236B CARBOXYLIC ACID DERIVATIVES
US4782084A (en) * 1987-06-29 1988-11-01 Merck & Co., Inc. HMG-COA reductase inhibitors
US4997848A (en) * 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
CA2062023A1 (en) * 1992-02-10 1993-08-11 Jagroop S. Dahiya Novel fungal strains and use thereof in antibiotic production
NZ247617A (en) 1992-05-15 1995-07-26 Sankyo Co Octahydronaphthalene oxime derivatives and pharmaceutical compositions
US6812007B1 (en) * 1992-11-04 2004-11-02 Keri Vilmos Process for the isolation and purification of mevinolin
HU210867B (en) * 1992-11-04 1995-10-30 Biogal Gyogyszergyar Method for extraction and purification of mevinolin from culture medium
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US5409820A (en) * 1993-08-06 1995-04-25 Apotex, Inc. Process for the production of lovastatin using Coniothyrium fuckelii
US6046022A (en) 1996-09-30 2000-04-04 Peking University Methods and compositions employing red rice fermentation products
US7238348B2 (en) 1996-09-30 2007-07-03 Beijing Peking University Wbl Corporation Ltd. Method of treatment of osteoporosis with compositions of red rice fermentation products
AU753564B2 (en) 1998-03-20 2002-10-24 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Metabolic controlled fermentation procedure for the manufacture of lovastatin hydroxy acid
WO2001062949A1 (en) 2000-02-24 2001-08-30 Biogal Gyogyszergyar Rt Method of purifying a fermentation broth
TR200403001T3 (en) 2000-03-03 2005-02-21 Plus Chemical, S.A. A process for the treatment of lovastatin and simvastatin with reduced dimeric impurity levels
KR20010095780A (en) * 2000-04-12 2001-11-07 나가오카 마사시 Embryo monascus
IN192861B (en) 2000-06-30 2004-05-22 Ranbaxy Lab Ltd
WO2002063976A1 (en) 2001-02-09 2002-08-22 Unilever N.V. Food product comprising soy protein and statins
KR100379075B1 (en) 2002-03-07 2003-04-08 Jinis Biopharmaceuticals Co Method for producing low cholesterol animal food product and food product therefrom
KR20020093147A (en) * 2002-05-30 2002-12-13 지니스생명공학 주식회사 Preventive and Dietary Supplement for adult chronic disease
KR100710500B1 (en) 2005-05-18 2007-04-24 고려대학교 산학협력단 Method for producing Monacolin K using Monascus sp
WO2010069593A1 (en) 2008-12-19 2010-06-24 Krka, D. D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
RO128803A0 (en) 2012-10-12 2013-09-30 Ion Gigel Fulga Composition for the treatment or prevention of dyslipidemias
CN110331151A (en) * 2019-04-11 2019-10-15 北京工商大学 The construction method of purple Monascus mokH gene overexpression bacterial strain
CN111297938A (en) * 2020-03-11 2020-06-19 北京康立生医药技术开发有限公司 Method for detecting lovastatin in composition for assisting in reducing blood fat

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1453425A (en) * 1974-06-07 1976-10-20 Sankyo Co 2-oxo-tetrahydropyran derivatives and fermentative process for producing the same
FR2456141A1 (en) * 1979-05-11 1980-12-05 Sankyo Co PROCESS FOR THE PREPARATION OF MONACOLIN K
EP0022478B1 (en) * 1979-06-15 1983-02-23 Merck & Co. Inc. Polyhydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl)-ethyl)-1-naphthylenyl-2-methylbutanoates, corresponding hydroxy acids, process for preparing and pharmaceutical compositions containing the same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1453425A (en) * 1974-06-07 1976-10-20 Sankyo Co 2-oxo-tetrahydropyran derivatives and fermentative process for producing the same
FR2313035A1 (en) * 1974-06-07 1976-12-31 Sankyo Co SUBSTANCES WITH PHYSIOLOGICAL ACTION AND THEIR PROCESS FOR PREPARATION BY FERMENTATION
FR2456141A1 (en) * 1979-05-11 1980-12-05 Sankyo Co PROCESS FOR THE PREPARATION OF MONACOLIN K
EP0022478B1 (en) * 1979-06-15 1983-02-23 Merck & Co. Inc. Polyhydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl)-ethyl)-1-naphthylenyl-2-methylbutanoates, corresponding hydroxy acids, process for preparing and pharmaceutical compositions containing the same

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2456141A1 (en) * 1979-05-11 1980-12-05 Sankyo Co PROCESS FOR THE PREPARATION OF MONACOLIN K
FR2479222A1 (en) * 1980-03-31 1981-10-02 Sankyo Co COMPOUND DERIVATIVES OF MONACOLIN K TYPE HAVING INHIBITORY ACTIVITY ON CHOLESTEROL BIOSYNTHESIS, PREPARATION METHOD AND THERAPEUTIC USE THEREOF
EP0074222A1 (en) * 1981-08-27 1983-03-16 Sankyo Company Limited MB-530B derivatives, their preparation and pharmaceutical compositions containing them
WO1993017991A1 (en) * 1992-03-04 1993-09-16 Fujisawa Pharmaceutical Co., Ltd. TETRALIN DERIVATIVES AS HMG-CoA REDUCTASE INHIBITORS

Also Published As

Publication number Publication date
FI66427B (en) 1984-06-29
CA1129794A (en) 1982-08-17
DK149095C (en) 1986-06-16
AT373915B (en) 1984-03-12
GB2046737A (en) 1980-11-19
ZA80962B (en) 1981-03-25
IE800321L (en) 1980-08-20
NO153974C (en) 1986-06-25
AU5567380A (en) 1980-08-28
DK149095B (en) 1986-01-20
DE3006216A1 (en) 1980-09-04
IT1175260B (en) 1987-07-01
AU532626B2 (en) 1983-10-06
DK73080A (en) 1980-08-21
HU182069B (en) 1983-12-28
NL8001041A (en) 1980-08-22
FR2449685B1 (en) 1985-06-28
MX6314E (en) 1985-04-01
IT8067262A0 (en) 1980-02-20
NZ192919A (en) 1984-07-06
CH645890A5 (en) 1984-10-31
SG6784G (en) 1985-02-08
GB2046737B (en) 1983-01-12
JPS5925599B2 (en) 1984-06-19
KR830002801B1 (en) 1983-12-16
BE881825A (en) 1980-08-20
SU1158048A3 (en) 1985-05-23
IE49743B1 (en) 1985-12-11
PL222120A1 (en) 1980-10-20
NO153974B (en) 1986-03-17
FI66427C (en) 1984-10-10
NL191540B (en) 1995-05-01
NL191540C (en) 1995-09-04
KR830002030A (en) 1983-05-21
ES8103171A1 (en) 1981-02-16
NO800451L (en) 1980-08-21
JPS55111790A (en) 1980-08-28
PL124304B1 (en) 1983-01-31
PH15145A (en) 1982-08-24
SE8001339L (en) 1980-08-21
SE453301B (en) 1988-01-25
DE3051175C2 (en) 1989-12-21
SU969702A1 (en) 1982-10-30
ES488796A0 (en) 1981-02-16
DD154494A5 (en) 1982-03-24
DE3006216C2 (en) 1985-10-31
DK21889D0 (en) 1989-01-18
DK21889A (en) 1989-01-18
ATA92980A (en) 1983-07-15
FI800506A (en) 1980-08-21

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