SE8001339L - Antihyperkolesteraemiskt medel, monakolin k och framstellning derav - Google Patents
Antihyperkolesteraemiskt medel, monakolin k och framstellning deravInfo
- Publication number
- SE8001339L SE8001339L SE8001339A SE8001339A SE8001339L SE 8001339 L SE8001339 L SE 8001339L SE 8001339 A SE8001339 A SE 8001339A SE 8001339 A SE8001339 A SE 8001339A SE 8001339 L SE8001339 L SE 8001339L
- Authority
- SE
- Sweden
- Prior art keywords
- antihypercolesteremic
- monacoline
- medicine
- preparation
- monascus
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Obesity (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP54017856A JPS5925599B2 (ja) | 1979-02-20 | 1979-02-20 | 新生理活性物質モナコリンkおよびその製造法 |
Publications (2)
Publication Number | Publication Date |
---|---|
SE8001339L true SE8001339L (sv) | 1980-08-21 |
SE453301B SE453301B (sv) | 1988-01-25 |
Family
ID=11955290
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8001339A SE453301B (sv) | 1979-02-20 | 1980-02-20 | Antihyperkolesterolemiskt medel, monakolin k, forfarande for framstellning derav samt farmaceutisk komposition innehallande detsamma |
Country Status (27)
Country | Link |
---|---|
JP (1) | JPS5925599B2 (sv) |
KR (1) | KR830002801B1 (sv) |
AT (1) | AT373915B (sv) |
AU (1) | AU532626B2 (sv) |
BE (1) | BE881825A (sv) |
CA (1) | CA1129794A (sv) |
CH (1) | CH645890A5 (sv) |
DD (1) | DD154494A5 (sv) |
DE (2) | DE3051175C2 (sv) |
DK (2) | DK149095C (sv) |
ES (1) | ES488796A0 (sv) |
FI (1) | FI66427C (sv) |
FR (1) | FR2449685B1 (sv) |
GB (1) | GB2046737B (sv) |
HU (1) | HU182069B (sv) |
IE (1) | IE49743B1 (sv) |
IT (1) | IT1175260B (sv) |
MX (1) | MX6314E (sv) |
NL (1) | NL191540C (sv) |
NO (1) | NO153974C (sv) |
NZ (1) | NZ192919A (sv) |
PH (1) | PH15145A (sv) |
PL (1) | PL124304B1 (sv) |
SE (1) | SE453301B (sv) |
SG (1) | SG6784G (sv) |
SU (2) | SU1158048A3 (sv) |
ZA (1) | ZA80962B (sv) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55150898A (en) * | 1979-05-11 | 1980-11-25 | Sankyo Co Ltd | Preparation of a new physiologically active substance mb-530b |
US4231938A (en) * | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
JPS5621594A (en) * | 1979-07-27 | 1981-02-28 | Sankyo Co Ltd | Mb-530b carboxylic acid metal salt and its preparation |
PT72394B (en) * | 1980-02-04 | 1982-09-06 | Merck & Co Inc | Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics |
AU548996B2 (en) * | 1980-02-04 | 1986-01-09 | Merck & Co., Inc. | Tetrahydro-2h-pyran-2-one derivatives |
JPH0692381B2 (ja) * | 1980-03-31 | 1994-11-16 | 三共株式会社 | Mb−530a誘導体 |
JPS56142236A (en) | 1980-04-08 | 1981-11-06 | Sankyo Co Ltd | Ml-236a and mb-530a derivative |
MX7065E (es) * | 1980-06-06 | 1987-04-10 | Sankyo Co | Un procedimiento microbiologico para preparar derivados de ml-236b |
JPS5835144A (ja) * | 1981-08-27 | 1983-03-01 | Sankyo Co Ltd | Mb−530b誘導体およびその製造法 |
US4782084A (en) * | 1987-06-29 | 1988-11-01 | Merck & Co., Inc. | HMG-COA reductase inhibitors |
US4997848A (en) | 1987-10-27 | 1991-03-05 | Sankyo Company, Limited | Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition |
CA2062023A1 (en) * | 1992-02-10 | 1993-08-11 | Jagroop S. Dahiya | Novel fungal strains and use thereof in antibiotic production |
EP0629184A1 (en) * | 1992-03-04 | 1994-12-21 | Fujisawa Pharmaceutical Co., Ltd. | TETRALIN DERIVATIVES AS HMG-CoA REDUCTASE INHIBITORS |
ZA933359B (en) | 1992-05-15 | 1993-12-08 | Sankyo Co | Octahydronaphthalene oxime derivatives for cholesterol biosynthesis inhibition, their preparation and use |
HU210867B (en) * | 1992-11-04 | 1995-10-30 | Biogal Gyogyszergyar | Method for extraction and purification of mevinolin from culture medium |
US6812007B1 (en) * | 1992-11-04 | 2004-11-02 | Keri Vilmos | Process for the isolation and purification of mevinolin |
SI9300303A (en) * | 1993-06-08 | 1994-12-31 | Krka Tovarna Zdravil | Process for isolation of hypolipemic effective substance |
US5409820A (en) * | 1993-08-06 | 1995-04-25 | Apotex, Inc. | Process for the production of lovastatin using Coniothyrium fuckelii |
US6046022A (en) | 1996-09-30 | 2000-04-04 | Peking University | Methods and compositions employing red rice fermentation products |
US7238348B2 (en) | 1996-09-30 | 2007-07-03 | Beijing Peking University Wbl Corporation Ltd. | Method of treatment of osteoporosis with compositions of red rice fermentation products |
IL132822A0 (en) | 1998-03-20 | 2001-03-19 | Biogal Gyogyszergyar | Metabolic controlled fermentation procedure for the manufacture of lovastatin hydroxy acid |
IL151290A0 (en) | 2000-02-24 | 2003-04-10 | Biogal Pharmaceutical Co Ltd | Method of purifying a fermentation broth |
DE01913139T1 (de) | 2000-03-03 | 2005-03-31 | Plus Chemical S.A. | Ein verfahren zur reinigung von lovastatin und simvastatin mit verringertem gehalt an dimeren verunreinigungen |
KR20010095780A (ko) * | 2000-04-12 | 2001-11-07 | 나가오카 마사시 | 배아 홍국 |
IN192861B (sv) | 2000-06-30 | 2004-05-22 | Ranbaxy Lab Ltd | |
ATE356554T1 (de) | 2001-02-09 | 2007-04-15 | Unilever Nv | Nahrungsmittel enthaltend sojaprotein und statin |
KR100379075B1 (en) | 2002-03-07 | 2003-04-08 | Jinis Biopharmaceuticals Co | Method for producing low cholesterol animal food product and food product therefrom |
KR20020093147A (ko) * | 2002-05-30 | 2002-12-13 | 지니스생명공학 주식회사 | 성인병 예방 및 치료 보조제 |
KR100710500B1 (ko) | 2005-05-18 | 2007-04-24 | 고려대학교 산학협력단 | 홍국균을 이용한 모나콜린 k 생산방법 |
WO2010069593A1 (en) | 2008-12-19 | 2010-06-24 | Krka, D. D., Novo Mesto | Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates |
EP2327682A1 (en) | 2009-10-29 | 2011-06-01 | KRKA, D.D., Novo Mesto | Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates |
RO128803A0 (ro) | 2012-10-12 | 2013-09-30 | Ion Gigel Fulga | Compoziţie pentru tratamentul sau prevenirea dislipidemiilor |
CN110331151A (zh) * | 2019-04-11 | 2019-10-15 | 北京工商大学 | 紫色红曲菌mokH基因过表达菌株的构建方法 |
CN111297938A (zh) * | 2020-03-11 | 2020-06-19 | 北京康立生医药技术开发有限公司 | 一种辅助降血脂组合物中洛伐他汀的检测方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5612114B2 (sv) * | 1974-06-07 | 1981-03-18 | ||
JPS55150898A (en) * | 1979-05-11 | 1980-11-25 | Sankyo Co Ltd | Preparation of a new physiologically active substance mb-530b |
AU535944B2 (en) * | 1979-06-15 | 1984-04-12 | Merck & Co., Inc. | Hypocholestermic fermentation products from aspergillus |
-
1979
- 1979-02-20 JP JP54017856A patent/JPS5925599B2/ja not_active Expired
-
1980
- 1980-02-19 KR KR1019800000654A patent/KR830002801B1/ko active
- 1980-02-19 IE IE321/80A patent/IE49743B1/en not_active IP Right Cessation
- 1980-02-19 AU AU55673/80A patent/AU532626B2/en not_active Expired
- 1980-02-19 CA CA345,983A patent/CA1129794A/en not_active Expired
- 1980-02-20 CH CH136680A patent/CH645890A5/de not_active IP Right Cessation
- 1980-02-20 PH PH23668A patent/PH15145A/en unknown
- 1980-02-20 ZA ZA00800962A patent/ZA80962B/xx unknown
- 1980-02-20 GB GB8005748A patent/GB2046737B/en not_active Expired
- 1980-02-20 PL PL1980222120A patent/PL124304B1/pl unknown
- 1980-02-20 IT IT67262/80A patent/IT1175260B/it active
- 1980-02-20 FI FI800506A patent/FI66427C/fi not_active IP Right Cessation
- 1980-02-20 ES ES488796A patent/ES488796A0/es active Granted
- 1980-02-20 DK DK73080A patent/DK149095C/da not_active IP Right Cessation
- 1980-02-20 DD DD80219159A patent/DD154494A5/de unknown
- 1980-02-20 BE BE0/199476A patent/BE881825A/fr not_active IP Right Cessation
- 1980-02-20 DE DE3051175A patent/DE3051175C2/de not_active Expired
- 1980-02-20 DE DE3006216A patent/DE3006216C2/de not_active Expired
- 1980-02-20 NL NL8001041A patent/NL191540C/xx not_active IP Right Cessation
- 1980-02-20 NO NO800451A patent/NO153974C/no unknown
- 1980-02-20 SE SE8001339A patent/SE453301B/sv not_active IP Right Cessation
- 1980-02-20 NZ NZ192919A patent/NZ192919A/en unknown
- 1980-02-20 MX MX808652U patent/MX6314E/es unknown
- 1980-02-20 FR FR8003662A patent/FR2449685B1/fr not_active Expired
- 1980-02-20 HU HU80397A patent/HU182069B/hu unknown
- 1980-02-20 SU SU802887300A patent/SU1158048A3/ru active
- 1980-02-20 AT AT0092980A patent/AT373915B/de not_active IP Right Cessation
- 1980-09-12 SU SU802977031A patent/SU969702A1/ru active
-
1984
- 1984-01-24 SG SG67/84A patent/SG6784G/en unknown
-
1989
- 1989-01-18 DK DK021889A patent/DK21889A/da not_active Application Discontinuation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SE8001339L (sv) | Antihyperkolesteraemiskt medel, monakolin k och framstellning derav | |
Tamura et al. | Ascochlorin, a new antibiotic, found by paper-disc agar-diffusion method. I isolation, biological and chemical properties of ascochlorin (studies on antiviral and antitumor antibiotics. I) | |
NO176766C (no) | Fremgangsmåte for fremstilling av en forbindelse med anthelmintaktivitet | |
FI931680A (fi) | Foerbaettrat foerfarande foer syntetisering av (4r-cis)-1,1-dimetyletyl-6-cyanometyl-2,2-dimetyl-1,3-dioxan-4-acetat | |
SE8001338L (sv) | "monacolin k"-framstellning | |
DE69017946T2 (de) | Zellwachstum hemmende makrozyklische Lactone namens Combretastatin D-2. | |
BR8600329A (pt) | Composto de 1,3-tiazol,processo para a sua preparacao,composicao inseticida e processo para combater insetos | |
JPS5592387A (en) | Antibiotic substance tm-531 | |
JPS56128774A (en) | New physiologically active substance ebelactone and its preparation | |
SE8100134L (sv) | Terpenoider, forfaranden for framstellning av desamma och farmaceutiska kompositioner innehallande desamma | |
KR890014457A (ko) | 신규 아족시 화합물 및 그의 제조방법 | |
KR880000594A (ko) | 세균생산물질 ufc-n11, 그의 제조방법 및 용도 | |
SE7513671L (sv) | Desacyl-pepsidin och sett att framstella densamma | |
SE7910626L (sv) | Ny antibiotisk bn-183b-substans och forfarande for framstellning derav | |
FI810710L (fi) | Oligoribocidderivat av homocitronsyra foerfarande foer framstaellning av dessa och anvaendningen av dessa foer foerhindrande av karies | |
GB2093347B (en) | Immunostimulant material tf-2 from fusobacterium sp | |
KR890003734A (ko) | 신규한 nf-1616-904의 피라진옥사이드 화합물 및 이를 함유하는 약학 조성물 | |
SE7711542L (sv) | Forfarande for framstellning av ett nytt antibiotikum c-15003 och hydrolysderivat derav | |
SE8005921L (sv) | Nya foreningar med karcinostatisk och immunostimulerande aktivitet samt forfarande for framstellning derav | |
JPS5692786A (en) | Cultivation of microorganism | |
JPS5651435A (en) | Novel substance dc-44-a and dc-44-b, and their preparation | |
KR920002497A (ko) | 스테롤 화합물 | |
JPS54128575A (en) | Novel pentalenonelactone compound and drugs comprising it as active constituent | |
JPS5492680A (en) | Novel microorganism | |
JPS574975A (en) | Phenazine derivative and its preparation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
NAL | Patent in force |
Ref document number: 8001339-4 Format of ref document f/p: F |
|
NUG | Patent has lapsed |
Ref document number: 8001339-4 Format of ref document f/p: F |