FI931680A - Foerbaettrat foerfarande foer syntetisering av (4r-cis)-1,1-dimetyletyl-6-cyanometyl-2,2-dimetyl-1,3-dioxan-4-acetat - Google Patents

Foerbaettrat foerfarande foer syntetisering av (4r-cis)-1,1-dimetyletyl-6-cyanometyl-2,2-dimetyl-1,3-dioxan-4-acetat Download PDF

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Publication number
FI931680A
FI931680A FI931680A FI931680A FI931680A FI 931680 A FI931680 A FI 931680A FI 931680 A FI931680 A FI 931680A FI 931680 A FI931680 A FI 931680A FI 931680 A FI931680 A FI 931680A
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Finland
Prior art keywords
cyanomethyl
cis
dimethyl
acetate
syntetisering
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FI931680A
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English (en)
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FI931680A0 (fi
FI108539B (fi
Inventor
Alan Millar
Donald Eugene Butler
Original Assignee
Warner Lambert Co
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Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of FI931680A0 publication Critical patent/FI931680A0/fi
Publication of FI931680A publication Critical patent/FI931680A/fi
Application granted granted Critical
Publication of FI108539B publication Critical patent/FI108539B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
FI931680A 1990-10-17 1993-04-14 Parannettu menetelmä (4R-cis)-1,1-dimetyylietyyli-6-syanometyyli-2,2-dimetyyli-1,3-dioksaani-4-asetaatin syntetisoimiseksi FI108539B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US59952190 1990-10-17
US07/599,521 US5103024A (en) 1990-10-17 1990-10-17 Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
PCT/US1991/006697 WO1992006968A1 (en) 1990-10-17 1991-09-11 Process for the synthesis of (4r-cis)-1,1-dimethylethyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US9106697 1991-09-11

Publications (3)

Publication Number Publication Date
FI931680A0 FI931680A0 (fi) 1993-04-14
FI931680A true FI931680A (fi) 1993-04-14
FI108539B FI108539B (fi) 2002-02-15

Family

ID=24399962

Family Applications (1)

Application Number Title Priority Date Filing Date
FI931680A FI108539B (fi) 1990-10-17 1993-04-14 Parannettu menetelmä (4R-cis)-1,1-dimetyylietyyli-6-syanometyyli-2,2-dimetyyli-1,3-dioksaani-4-asetaatin syntetisoimiseksi

Country Status (20)

Country Link
US (1) US5103024A (fi)
EP (1) EP0553213B1 (fi)
JP (1) JP3105923B2 (fi)
KR (1) KR0166385B1 (fi)
AT (1) ATE118772T1 (fi)
AU (1) AU646311B2 (fi)
CA (1) CA2092997C (fi)
CZ (5) CZ282922B6 (fi)
DE (1) DE69107622T2 (fi)
DK (1) DK0553213T3 (fi)
ES (1) ES2070519T3 (fi)
FI (1) FI108539B (fi)
HK (1) HK1005026A1 (fi)
HU (2) HU219237B (fi)
IE (1) IE62940B1 (fi)
NO (1) NO301588B1 (fi)
PT (1) PT99244B (fi)
RU (1) RU2067580C1 (fi)
SK (5) SK280940B6 (fi)
WO (1) WO1992006968A1 (fi)

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SI20848A (sl) 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
MXPA03010266A (es) 2001-06-29 2004-03-10 Warner Lambert Co Formas cristalinas de la sal de calcio del acido [r-(r*, r*)]-2 -(4-fluorofenil)-¦, d-dihidroxi-5 -(1-metiletil)-3 -fenil-4- [(fenilamino) carbonil ]-1h- pirrol-1-heptanoico (2:1) (atorvastatin).
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JP2005500351A (ja) 2001-07-30 2005-01-06 ドクター・レディーズ・ラボラトリーズ・リミテッド 結晶形態ｖｉおよびｖｉｉのアトルバスタチンカルシウム
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AU2001284385A1 (en) * 2001-08-31 2003-03-10 Morepen Laboratories Ltd. An improved process for the preparation of amorphous atorvastatin calcium salt (2:1)
HU227124B1 (en) * 2001-09-14 2010-07-28 Egis Gyogyszergyar Nyilvanosan Polymorphs of 1-pyrrole derivative, intermediate for the preparation of atorvastatin
UA77990C2 (en) * 2001-12-12 2007-02-15 Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
CZ296967B6 (cs) * 2002-02-01 2006-08-16 Zentiva, A.S. Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu)
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US20040248972A1 (en) * 2003-05-16 2004-12-09 Ambit Biosciences Corporation Compounds and uses thereof
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KR100781420B1 (ko) * 2003-09-17 2007-12-03 워너-램버트 캄파니 엘엘씨 [Ｒ-(Ｒ*,Ｒ*)]-2-(4-플루오로페닐)-β,δ-다이하이드록시-5-(1-메틸에틸)-3-페닐-4-[(페닐아미노)카보닐]-1Ｈ-피롤-1-헵탄산의 결정성 형태
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SI1727795T1 (sl) 2004-03-17 2012-05-31 Ranbaxy Lab Ltd Postopek za pripravo atorvastatin kalcija v amorfni obliki
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US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
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Also Published As

Publication number Publication date
SK280938B6 (sk) 2000-09-12
CZ124797A3 (en) 1997-12-17
EP0553213A1 (en) 1993-08-04
NO931421D0 (no) 1993-04-16
SK280941B6 (sk) 2000-09-12
SK280939B6 (sk) 2000-09-12
RU2067580C1 (ru) 1996-10-10
IE62940B1 (en) 1995-03-08
FI931680A0 (fi) 1993-04-14
FI108539B (fi) 2002-02-15
SK280942B6 (sk) 2000-09-12
HUT64049A (en) 1993-11-29
SK280940B6 (sk) 2000-09-12
AU8848091A (en) 1992-05-20
CZ282922B6 (cs) 1997-11-12
CZ282994B6 (cs) 1997-12-17
CZ124697A3 (en) 1997-12-17
HU219237B (en) 2001-03-28
IE913629A1 (en) 1992-04-22
CZ209495A3 (en) 1997-12-17
HK1005026A1 (en) 1998-12-18
CA2092997A1 (en) 1992-04-18
EP0553213B1 (en) 1995-02-22
KR0166385B1 (en) 1999-01-15
DK0553213T3 (da) 1995-07-17
DE69107622D1 (de) 1995-03-30
JPH06502162A (ja) 1994-03-10
CZ61493A3 (en) 1994-02-16
US5103024A (en) 1992-04-07
DE69107622T2 (de) 1995-07-06
CZ282993B6 (cs) 1997-12-17
CA2092997C (en) 2002-05-14
SK33993A3 (en) 1993-10-06
HU9301122D0 (en) 1993-08-30
PT99244B (pt) 1999-04-30
PT99244A (pt) 1992-09-30
CZ282992B6 (cs) 1997-12-17
KR930702328A (ko) 1993-09-08
AU646311B2 (en) 1994-02-17
HU9701183D0 (en) 1997-09-29
ES2070519T3 (es) 1995-06-01
JP3105923B2 (ja) 2000-11-06
WO1992006968A1 (en) 1992-04-30
HU213731B (en) 1997-09-29
NO931421L (no) 1993-06-16
NO301588B1 (no) 1997-11-17
CZ283003B6 (cs) 1997-12-17
ATE118772T1 (de) 1995-03-15
CZ124597A3 (en) 1997-12-17

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