DE69107622D1 - Verfahren zur herstellung von (4r-cis)-1,1-dimethylethyl-6-cyanmethyl-2,2-dimethyl-1,3-dioxan-4-acetat. - Google Patents

Verfahren zur herstellung von (4r-cis)-1,1-dimethylethyl-6-cyanmethyl-2,2-dimethyl-1,3-dioxan-4-acetat.

Info

Publication number
DE69107622D1
DE69107622D1 DE69107622T DE69107622T DE69107622D1 DE 69107622 D1 DE69107622 D1 DE 69107622D1 DE 69107622 T DE69107622 T DE 69107622T DE 69107622 T DE69107622 T DE 69107622T DE 69107622 D1 DE69107622 D1 DE 69107622D1
Authority
DE
Germany
Prior art keywords
dimethylethyl
dioxane
cis
dimethyl
acetate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69107622T
Other languages
English (en)
Other versions
DE69107622T2 (de
Inventor
Alan Millar
Donald BUTLER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of DE69107622D1 publication Critical patent/DE69107622D1/de
Application granted granted Critical
Publication of DE69107622T2 publication Critical patent/DE69107622T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
DE69107622T 1990-10-17 1991-09-11 Verfahren zur herstellung von (4r-cis)-1,1-dimethylethyl-6-cyanmethyl-2,2-dimethyl-1,3-dioxan-4-acetat. Expired - Fee Related DE69107622T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/599,521 US5103024A (en) 1990-10-17 1990-10-17 Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
PCT/US1991/006697 WO1992006968A1 (en) 1990-10-17 1991-09-11 Process for the synthesis of (4r-cis)-1,1-dimethylethyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate

Publications (2)

Publication Number Publication Date
DE69107622D1 true DE69107622D1 (de) 1995-03-30
DE69107622T2 DE69107622T2 (de) 1995-07-06

Family

ID=24399962

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69107622T Expired - Fee Related DE69107622T2 (de) 1990-10-17 1991-09-11 Verfahren zur herstellung von (4r-cis)-1,1-dimethylethyl-6-cyanmethyl-2,2-dimethyl-1,3-dioxan-4-acetat.

Country Status (20)

Country Link
US (1) US5103024A (de)
EP (1) EP0553213B1 (de)
JP (1) JP3105923B2 (de)
KR (1) KR0166385B1 (de)
AT (1) ATE118772T1 (de)
AU (1) AU646311B2 (de)
CA (1) CA2092997C (de)
CZ (5) CZ282992B6 (de)
DE (1) DE69107622T2 (de)
DK (1) DK0553213T3 (de)
ES (1) ES2070519T3 (de)
FI (1) FI108539B (de)
HK (1) HK1005026A1 (de)
HU (2) HU213731B (de)
IE (1) IE62940B1 (de)
NO (1) NO301588B1 (de)
PT (1) PT99244B (de)
RU (1) RU2067580C1 (de)
SK (5) SK280938B6 (de)
WO (1) WO1992006968A1 (de)

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HRP960312B1 (en) 1995-07-17 2001-10-31 Warner Lambert Co NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS /R-(R*, R*)/-2-(4-FLUOROPHENYL)-"beta", "delta"-DIHYDROXY-5-PHENYL-4-/(PHENYLAMINO)CARBONYL/-1H-PYRROLE -1-HEPTANOIC ACID CALCIUM SALT (2 : 1)
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SI20814A (sl) * 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
SI20848A (sl) 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
PL367943A1 (en) 2001-06-29 2005-03-07 Warner-Lambert Company Llc Crystalline forms of 'r-(r*,r*)!-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-'phenylamino)carbonyl!-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
GB0116212D0 (en) * 2001-07-03 2001-08-29 Avecia Ltd Process
EP2292600A1 (de) 2001-07-30 2011-03-09 Dr. Reddy's Laboratories Ltd. Kristalline Formen VI und VII von Atorvastatin Calcium
PE20030324A1 (es) * 2001-07-31 2003-04-03 Warner Lambert Co Composiciones farmaceuticas de amlodipina y atorvastatina
US7563911B2 (en) * 2001-08-31 2009-07-21 Morepen Laboratories Ltd. Process for the preparation of amorphous atorvastin calcium salt (2:1)
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UA77990C2 (en) * 2001-12-12 2007-02-15 Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
CZ296967B6 (cs) 2002-02-01 2006-08-16 Zentiva, A.S. Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu)
DE10212492B4 (de) * 2002-03-21 2012-02-02 Daimler Ag Kolbenpumpe
AU2003251523A1 (en) * 2002-06-13 2003-12-31 Diversa Corporation Processes for making (r)-ethyl 4-cyano-3-hydroxybutyric acid
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US20060122403A1 (en) * 2002-09-03 2006-06-08 Sanjay Suri Atorvastatin calcium form vi or hydrates thereof
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WO2004089894A1 (en) * 2003-04-14 2004-10-21 Warner-Lambert Company Llc Process for preparing 5-(4-fluorophenyl)-1-[2-((2r,4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
US20050182125A1 (en) * 2003-05-16 2005-08-18 Ambit Biosciences Corporation Pyrrole compounds and uses thereof
US20040248972A1 (en) * 2003-05-16 2004-12-09 Ambit Biosciences Corporation Compounds and uses thereof
JP2007500219A (ja) * 2003-05-16 2007-01-11 アンビット バイオサイエンシス コーポレーション 複素環化合物およびその使用法
US7790197B2 (en) * 2003-06-09 2010-09-07 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
US20050271717A1 (en) * 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
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US7655692B2 (en) * 2003-06-12 2010-02-02 Pfizer Inc. Process for forming amorphous atorvastatin
WO2005012246A1 (en) * 2003-07-25 2005-02-10 Avecia Pharmaceuticals Limited Process and intermediate compounds useful in the preparation of statins, particularly atorvastatin
CN101318923A (zh) * 2003-09-17 2008-12-10 沃尼尔·朗伯有限责任公司 [R－(R*,R*)]－2－(4－氟苯基)－β,δ－二羟基－5－(1－甲基乙基)－3－苯基－4－[(苯基氨基)羰基]－1H－吡咯－1－庚酸的结晶形式
CA2456430A1 (en) * 2004-01-28 2005-07-28 Brantford Chemicals Inc. Improved process for the preparation of amorphous atorvastatin calcium
EP1577297A1 (de) 2004-03-17 2005-09-21 Ranbaxy Laboratories, Ltd. Verfahren zur Herstellung von amorphem Atorvastatin Kalzium
JP2007532622A (ja) * 2004-04-16 2007-11-15 ファイザー・プロダクツ・インク 非晶質アトルバスタチン・カルシウムの形成方法
US7875731B2 (en) 2004-05-05 2011-01-25 Pfizer Inc. Salt forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)Carbonyl]-1H-pyrrole-1-heptanoic acid
CA2573969C (en) * 2004-07-16 2014-02-04 Lek Pharmaceuticals D.D. Oxidative degradation products of atorvastatin calcium
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US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
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Also Published As

Publication number Publication date
CZ124597A3 (en) 1997-12-17
FI931680A (fi) 1993-04-14
HU219237B (en) 2001-03-28
IE913629A1 (en) 1992-04-22
NO301588B1 (no) 1997-11-17
IE62940B1 (en) 1995-03-08
SK280938B6 (sk) 2000-09-12
AU8848091A (en) 1992-05-20
NO931421D0 (no) 1993-04-16
CZ61493A3 (en) 1994-02-16
JP3105923B2 (ja) 2000-11-06
WO1992006968A1 (en) 1992-04-30
HUT64049A (en) 1993-11-29
EP0553213B1 (de) 1995-02-22
ES2070519T3 (es) 1995-06-01
CZ282993B6 (cs) 1997-12-17
SK280940B6 (sk) 2000-09-12
EP0553213A1 (de) 1993-08-04
NO931421L (no) 1993-06-16
HU9701183D0 (en) 1997-09-29
JPH06502162A (ja) 1994-03-10
KR0166385B1 (en) 1999-01-15
HU9301122D0 (en) 1993-08-30
US5103024A (en) 1992-04-07
FI108539B (fi) 2002-02-15
CZ124797A3 (en) 1997-12-17
PT99244B (pt) 1999-04-30
CZ282992B6 (cs) 1997-12-17
CZ209495A3 (en) 1997-12-17
HU213731B (en) 1997-09-29
PT99244A (pt) 1992-09-30
CA2092997A1 (en) 1992-04-18
CZ282922B6 (cs) 1997-11-12
AU646311B2 (en) 1994-02-17
DK0553213T3 (da) 1995-07-17
SK280941B6 (sk) 2000-09-12
SK280939B6 (sk) 2000-09-12
SK33993A3 (en) 1993-10-06
FI931680A0 (fi) 1993-04-14
CA2092997C (en) 2002-05-14
SK280942B6 (sk) 2000-09-12
HK1005026A1 (en) 1998-12-18
CZ124697A3 (en) 1997-12-17
DE69107622T2 (de) 1995-07-06
RU2067580C1 (ru) 1996-10-10
ATE118772T1 (de) 1995-03-15
CZ282994B6 (cs) 1997-12-17
KR930702328A (ko) 1993-09-08
CZ283003B6 (cs) 1997-12-17

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