ATE269863T1 - Verfahren zur herstellung von granisetron - Google Patents
Verfahren zur herstellung von granisetronInfo
- Publication number
- ATE269863T1 ATE269863T1 AT97904526T AT97904526T ATE269863T1 AT E269863 T1 ATE269863 T1 AT E269863T1 AT 97904526 T AT97904526 T AT 97904526T AT 97904526 T AT97904526 T AT 97904526T AT E269863 T1 ATE269863 T1 AT E269863T1
- Authority
- AT
- Austria
- Prior art keywords
- granisetron
- producing
- producing granisetron
- cyclising
- compound
- Prior art date
Links
- MFWNKCLOYSRHCJ-BTTYYORXSA-N granisetron Chemical compound C1=CC=C2C(C(=O)N[C@H]3C[C@H]4CCC[C@@H](C3)N4C)=NN(C)C2=C1 MFWNKCLOYSRHCJ-BTTYYORXSA-N 0.000 title abstract 2
- 229960003727 granisetron Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Otolaryngology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9602866.7A GB9602866D0 (en) | 1996-02-13 | 1996-02-13 | Novel process |
| PCT/GB1997/000380 WO1997030049A1 (en) | 1996-02-13 | 1997-02-11 | Process for the preparation of granisetron |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE269863T1 true ATE269863T1 (de) | 2004-07-15 |
Family
ID=10788578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97904526T ATE269863T1 (de) | 1996-02-13 | 1997-02-11 | Verfahren zur herstellung von granisetron |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6268498B1 (de) |
| EP (1) | EP0882045B1 (de) |
| JP (1) | JP2000504715A (de) |
| AT (1) | ATE269863T1 (de) |
| DE (1) | DE69729631T2 (de) |
| ES (1) | ES2221951T3 (de) |
| GB (1) | GB9602866D0 (de) |
| PT (1) | PT882045E (de) |
| WO (1) | WO1997030049A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9506119D0 (en) * | 1995-03-25 | 1995-05-10 | Smithkline Beecham Plc | Chemical process |
| ES2197001B1 (es) | 2002-03-26 | 2004-11-16 | Laboratorios Vita, S.A. | Procedimiento de obtencion de un compuesto farmaceuticamente activo. |
| RU2420525C2 (ru) * | 2005-07-11 | 2011-06-10 | Мицубиси Танабе Фарма Корпорейшн | Производные оксимов и их получение |
| WO2007088557A1 (en) * | 2006-02-01 | 2007-08-09 | Natco Pharma Limited | Process for highly pure crystalline granisetron base |
| US8304426B2 (en) | 2007-06-13 | 2012-11-06 | Inke, S.A. | Polymorphic form of Granisetron base, methods for obtaining it and formulation containing it |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3687080T2 (de) | 1985-04-27 | 1993-03-25 | Beecham Group Plc | Azabicyclononyl-indazol-carboxamid mit 5-ht-antagonistischer wirkung. |
-
1996
- 1996-02-13 GB GBGB9602866.7A patent/GB9602866D0/en active Pending
-
1997
- 1997-02-11 AT AT97904526T patent/ATE269863T1/de active
- 1997-02-11 EP EP97904526A patent/EP0882045B1/de not_active Expired - Lifetime
- 1997-02-11 JP JP9529084A patent/JP2000504715A/ja active Pending
- 1997-02-11 ES ES97904526T patent/ES2221951T3/es not_active Expired - Lifetime
- 1997-02-11 PT PT97904526T patent/PT882045E/pt unknown
- 1997-02-11 DE DE69729631T patent/DE69729631T2/de not_active Expired - Lifetime
- 1997-02-11 US US09/125,199 patent/US6268498B1/en not_active Expired - Lifetime
- 1997-02-11 WO PCT/GB1997/000380 patent/WO1997030049A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| GB9602866D0 (en) | 1996-04-10 |
| DE69729631D1 (de) | 2004-07-29 |
| PT882045E (pt) | 2004-10-29 |
| US6268498B1 (en) | 2001-07-31 |
| JP2000504715A (ja) | 2000-04-18 |
| WO1997030049A1 (en) | 1997-08-21 |
| EP0882045A1 (de) | 1998-12-09 |
| EP0882045B1 (de) | 2004-06-23 |
| ES2221951T3 (es) | 2005-01-16 |
| DE69729631T2 (de) | 2005-06-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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