DE69729631D1 - Verfahren zur herstellung von granisetron - Google Patents

Verfahren zur herstellung von granisetron

Info

Publication number
DE69729631D1
DE69729631D1 DE69729631T DE69729631T DE69729631D1 DE 69729631 D1 DE69729631 D1 DE 69729631D1 DE 69729631 T DE69729631 T DE 69729631T DE 69729631 T DE69729631 T DE 69729631T DE 69729631 D1 DE69729631 D1 DE 69729631D1
Authority
DE
Germany
Prior art keywords
granisetron
producing
producing granisetron
cyclising
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69729631T
Other languages
English (en)
Other versions
DE69729631T2 (de
Inventor
Neal Ward
Alan Jones
Witold Jacewicz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE69729631D1 publication Critical patent/DE69729631D1/de
Publication of DE69729631T2 publication Critical patent/DE69729631T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Otolaryngology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69729631T 1996-02-13 1997-02-11 Verfahren zur herstellung von granisetron Expired - Lifetime DE69729631T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9602866.7A GB9602866D0 (en) 1996-02-13 1996-02-13 Novel process
GB9602866 1996-02-13
PCT/GB1997/000380 WO1997030049A1 (en) 1996-02-13 1997-02-11 Process for the preparation of granisetron

Publications (2)

Publication Number Publication Date
DE69729631D1 true DE69729631D1 (de) 2004-07-29
DE69729631T2 DE69729631T2 (de) 2005-06-09

Family

ID=10788578

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69729631T Expired - Lifetime DE69729631T2 (de) 1996-02-13 1997-02-11 Verfahren zur herstellung von granisetron

Country Status (9)

Country Link
US (1) US6268498B1 (de)
EP (1) EP0882045B1 (de)
JP (1) JP2000504715A (de)
AT (1) ATE269863T1 (de)
DE (1) DE69729631T2 (de)
ES (1) ES2221951T3 (de)
GB (1) GB9602866D0 (de)
PT (1) PT882045E (de)
WO (1) WO1997030049A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9506119D0 (en) * 1995-03-25 1995-05-10 Smithkline Beecham Plc Chemical process
ES2197001B1 (es) * 2002-03-26 2004-11-16 Laboratorios Vita, S.A. Procedimiento de obtencion de un compuesto farmaceuticamente activo.
CA2613303C (en) * 2005-07-11 2012-06-19 Mitsubishi Tanabe Pharma Corporation An oxime derivative for use as a glucokinase activator
WO2007088557A1 (en) * 2006-02-01 2007-08-09 Natco Pharma Limited Process for highly pure crystalline granisetron base
EP2164848B1 (de) 2007-06-13 2016-02-24 Inke, S.A. Polymorphe form von granisetronbase, verfahren zu deren gewinnung und formulierung, die diese enthält

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3650772T2 (de) * 1985-04-27 2003-04-03 Hoffmann La Roche Derivate von Indazole-3-carboxamide und -3-carboxylsäure

Also Published As

Publication number Publication date
GB9602866D0 (en) 1996-04-10
WO1997030049A1 (en) 1997-08-21
JP2000504715A (ja) 2000-04-18
ATE269863T1 (de) 2004-07-15
PT882045E (pt) 2004-10-29
EP0882045B1 (de) 2004-06-23
US6268498B1 (en) 2001-07-31
ES2221951T3 (es) 2005-01-16
DE69729631T2 (de) 2005-06-09
EP0882045A1 (de) 1998-12-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition