BRPI0519996A2 - processo para formar atorvastatina amorfa - Google Patents

processo para formar atorvastatina amorfa

Info

Publication number
BRPI0519996A2
BRPI0519996A2 BRPI0519996-4A BRPI0519996A BRPI0519996A2 BR PI0519996 A2 BRPI0519996 A2 BR PI0519996A2 BR PI0519996 A BRPI0519996 A BR PI0519996A BR PI0519996 A2 BRPI0519996 A2 BR PI0519996A2
Authority
BR
Brazil
Prior art keywords
atorvastatin
solvent
amorphous atorvastatin
form amorphous
agent
Prior art date
Application number
BRPI0519996-4A
Other languages
English (en)
Inventor
Antone John Debettencourt Iii
Peter Robert Rose
Evgenyi Yur'evich Shalaev
George Joseph Quallich
Carl Bernard Ziegler
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35954050&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0519996(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BRPI0519996A2 publication Critical patent/BRPI0519996A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

PROCESSO PARA FORMAR ATORVASTATINA AMORFA. A presente invenção refere-se a um processo para formar atorvastatina amorfa compreendendo as etapas de dissolver atorvastatina em um solvente não hidroxílico e remover o solvente por secagem por congelamento, assim como processos de dissolver atorvastatina em um solvente hidroxílico com um agente solubilizante ou um agente alcalinizante ou um antioxidante e remover o solvente por secagem por congelamento para dar atorvastatina amorfa.
BRPI0519996-4A 2004-10-28 2005-10-12 processo para formar atorvastatina amorfa BRPI0519996A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62308604P 2004-10-28 2004-10-28
PCT/IB2005/003173 WO2006046109A1 (en) 2004-10-28 2005-10-12 Process for forming amorphous atorvastatin

Publications (1)

Publication Number Publication Date
BRPI0519996A2 true BRPI0519996A2 (pt) 2009-04-07

Family

ID=35954050

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0519996-4A BRPI0519996A2 (pt) 2004-10-28 2005-10-12 processo para formar atorvastatina amorfa

Country Status (16)

Country Link
US (4) US7939675B2 (pt)
EP (1) EP1807055A1 (pt)
JP (1) JP2008517992A (pt)
KR (1) KR20070067175A (pt)
CN (1) CN101048141A (pt)
AR (1) AR051144A1 (pt)
AU (1) AU2005298383A1 (pt)
BR (1) BRPI0519996A2 (pt)
CA (1) CA2585836A1 (pt)
IL (1) IL182474A0 (pt)
MX (1) MX2007004722A (pt)
NZ (1) NZ554541A (pt)
RU (1) RU2007115543A (pt)
TW (1) TW200624419A (pt)
WO (1) WO2006046109A1 (pt)
ZA (1) ZA200702965B (pt)

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KR100833439B1 (ko) * 2007-01-02 2008-05-29 씨제이제일제당 (주) 비결정형 아토르바스타틴 칼슘의 개선된 제조방법
US20110142883A1 (en) * 2007-07-20 2011-06-16 Actavis Group Ptc Ehf Amorphous Coprecipitates of Atorvastatin Pharmaceutically Acceptable Salts
WO2010066846A2 (en) * 2008-12-11 2010-06-17 Dsm Ip Assets B.V. Method for the isolation of atorvastatin
CN101973922B (zh) * 2009-05-27 2013-01-23 天津和美生物技术有限公司 阿伐他汀半锶盐多晶型物、其制备和作为HMG-CoA酶抑制剂的应用
AU2014277744B2 (en) * 2010-04-16 2017-01-19 Cumberland Pharmaceuticals, Inc. Stabilized Statin Formulations
US8372877B2 (en) 2010-04-16 2013-02-12 Cumberland Pharmaceuticals Stabilized statin formulations
HUP1000299A2 (hu) 2010-06-08 2012-02-28 Nanoform Cardiovascular Therapeutics Ltd Nanostrukturált Atorvastatint, gyógyszerészetileg elfogadott sóit és kokristályait tartalmazó készítmény és eljárás elõállításukra
CN102139115B (zh) * 2011-03-30 2012-12-05 天津红日药业股份有限公司 阿托伐他汀的环糊精包合物及其口服固体制剂的制备方法
JP6226872B2 (ja) * 2011-11-22 2017-11-08 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓ Ｈｅａｌｔｈｃａｒｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｉｎｃ． キャリブレーションおよび／またはクオリティ・コントロール溶液として再構成用の乾燥試薬を含むデバイスとその製造および使用方法
EP2924022A1 (en) * 2014-03-27 2015-09-30 INDENA S.p.A. Amorphous form of a thiocolchicine derivative
JP7350019B2 (ja) * 2018-05-31 2023-09-25 イミュニティ ファルマ リミテッド 筋萎縮性側索硬化症（ａｌｓ）を治療するための組成物、及び治療のためにそれを使用する方法
CN114569605A (zh) * 2022-03-10 2022-06-03 沈阳药科大学 阿托伐他汀-黄酮类化合物共无定型复合物及其制备方法

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Also Published As

Publication number Publication date
NZ554541A (en) 2011-01-28
US8258315B2 (en) 2012-09-04
CA2585836A1 (en) 2006-05-04
US20110237642A1 (en) 2011-09-29
MX2007004722A (es) 2007-06-15
EP1807055A1 (en) 2007-07-18
KR20070067175A (ko) 2007-06-27
TW200624419A (en) 2006-07-16
US20080269314A1 (en) 2008-10-30
IL182474A0 (en) 2007-07-24
US7939675B2 (en) 2011-05-10
US9056831B2 (en) 2015-06-16
ZA200702965B (en) 2008-10-29
RU2007115543A (ru) 2008-12-10
AU2005298383A1 (en) 2006-05-04
US20120289576A1 (en) 2012-11-15
JP2008517992A (ja) 2008-05-29
AR051144A1 (es) 2006-12-20
US8686163B2 (en) 2014-04-01
WO2006046109A1 (en) 2006-05-04
CN101048141A (zh) 2007-10-03
US20140155627A1 (en) 2014-06-05

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012.