DE69201959D1 - Verfahren zur Herstellung von 6,12-Dihydro-6-hydroxy-cannabidiol und dessen Anwendung zur Herstellung von trans-delta-9-Tetrahydrocannabinol. - Google Patents

Verfahren zur Herstellung von 6,12-Dihydro-6-hydroxy-cannabidiol und dessen Anwendung zur Herstellung von trans-delta-9-Tetrahydrocannabinol.

Info

Publication number
DE69201959D1
DE69201959D1 DE69201959T DE69201959T DE69201959D1 DE 69201959 D1 DE69201959 D1 DE 69201959D1 DE 69201959 T DE69201959 T DE 69201959T DE 69201959 T DE69201959 T DE 69201959T DE 69201959 D1 DE69201959 D1 DE 69201959D1
Authority
DE
Germany
Prior art keywords
cannabidiol
tetrahydrocannabinol
dihydro
delta
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69201959T
Other languages
English (en)
Other versions
DE69201959T2 (de
Inventor
Peter Dr Stoss
Peter Merrath
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MACK CHEM PHARM
Original Assignee
MACK CHEM PHARM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MACK CHEM PHARM filed Critical MACK CHEM PHARM
Priority to DE69201959T priority Critical patent/DE69201959T2/de
Publication of DE69201959D1 publication Critical patent/DE69201959D1/de
Application granted granted Critical
Publication of DE69201959T2 publication Critical patent/DE69201959T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/11—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
    • C07C37/14—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms by addition reactions, i.e. reactions involving at least one carbon-to-carbon unsaturated bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
DE69201959T 1991-01-09 1992-01-09 Verfahren zur Herstellung von 6,12-Dihydro-6-hydroxy-cannabidiol und dessen Anwendung zur Herstellung von trans-delta-9-Tetrahydrocannabinol. Expired - Fee Related DE69201959T2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE69201959T DE69201959T2 (de) 1991-01-09 1992-01-09 Verfahren zur Herstellung von 6,12-Dihydro-6-hydroxy-cannabidiol und dessen Anwendung zur Herstellung von trans-delta-9-Tetrahydrocannabinol.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4100441A DE4100441A1 (de) 1991-01-09 1991-01-09 Verfahren zur herstellung von 6,12-dihydro-6-hydroxy-cannabidiol und dessen verwendung zur herstellung von trans-delta-9-tetrahydrocannabinol
DE69201959T DE69201959T2 (de) 1991-01-09 1992-01-09 Verfahren zur Herstellung von 6,12-Dihydro-6-hydroxy-cannabidiol und dessen Anwendung zur Herstellung von trans-delta-9-Tetrahydrocannabinol.

Publications (2)

Publication Number Publication Date
DE69201959D1 true DE69201959D1 (de) 1995-05-18
DE69201959T2 DE69201959T2 (de) 1995-08-24

Family

ID=6422735

Family Applications (2)

Application Number Title Priority Date Filing Date
DE4100441A Withdrawn DE4100441A1 (de) 1991-01-09 1991-01-09 Verfahren zur herstellung von 6,12-dihydro-6-hydroxy-cannabidiol und dessen verwendung zur herstellung von trans-delta-9-tetrahydrocannabinol
DE69201959T Expired - Fee Related DE69201959T2 (de) 1991-01-09 1992-01-09 Verfahren zur Herstellung von 6,12-Dihydro-6-hydroxy-cannabidiol und dessen Anwendung zur Herstellung von trans-delta-9-Tetrahydrocannabinol.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE4100441A Withdrawn DE4100441A1 (de) 1991-01-09 1991-01-09 Verfahren zur herstellung von 6,12-dihydro-6-hydroxy-cannabidiol und dessen verwendung zur herstellung von trans-delta-9-tetrahydrocannabinol

Country Status (7)

Country Link
US (1) US5227537A (de)
EP (1) EP0494665B1 (de)
JP (1) JP2637659B2 (de)
AT (1) ATE121066T1 (de)
DE (2) DE4100441A1 (de)
DK (1) DK0494665T3 (de)
ES (1) ES2071351T3 (de)

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WO1999053917A1 (en) 1998-04-21 1999-10-28 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Cannabinoids as antioxidants and neuroprotectants
AU3910700A (en) 1999-03-22 2000-10-09 Immugen Pharmaceuticals, Inc. Treatment of immune diseases
US6566560B2 (en) 1999-03-22 2003-05-20 Immugen Pharmaceuticals, Inc. Resorcinolic compounds
AU2002213429A1 (en) * 2000-09-28 2002-04-08 Immugen Pharmaceuticals, Inc. Antiviral methods and compounds
WO2002026224A2 (en) * 2000-09-28 2002-04-04 Immugen Pharmaceuticals, Inc. Methods and compounds for inhibiting eicosanoid metabolism and platelet aggregation
DE10051427C1 (de) * 2000-10-17 2002-06-13 Adam Mueller Verfahren zur Herstellung eines Tetrahydrocannabinol- und Cannabidiol-haltigen Extraktes aus Cannabis-Pflanzenmaterial sowie Cannabis-Extrakte
DE10106024B4 (de) * 2001-02-09 2004-10-14 Thc Pharm Gmbh Verfahren zur Herstellung von Dronabinol
AU2008200935B2 (en) * 2001-02-05 2010-02-04 Thc Pharm The Health Concept Gmbh Method for the Production of Dronabinol
GB0112752D0 (en) * 2001-05-25 2001-07-18 Johnson Matthey Plc Synthesis of cannabinoids
GB0112748D0 (en) * 2001-05-25 2001-07-18 Johnson Matthey Plc Uncatalysed addition reactions
WO2003015700A2 (en) * 2001-08-15 2003-02-27 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Novel vasoconstrictor cannabinoid analogs
US20030232101A1 (en) * 2002-03-18 2003-12-18 Immugen Pharmaceuticals, Inc. Topical formulations of resorcinols and cannibinoids and methods of use
PL205945B1 (pl) * 2002-08-14 2010-06-30 Gw Pharma Ltd Sposób ekstrakcji kannabinoidów z materiałów roślinnych oraz sposób wytwarzania kompozycji farmaceutycznej
US7344736B2 (en) * 2002-08-14 2008-03-18 Gw Pharma Limited Extraction of pharmaceutically active components from plant materials
EP1613578A2 (de) * 2003-04-10 2006-01-11 Mallinckrodt Inc. Olivetol-cyclodextrin-komplexe und regioselektives verfahren zur herstellung von delta 9-tetrahydrocannabinol
EP1633733B1 (de) * 2003-05-20 2011-01-26 The University of Tennessee Research Foundation Cannabinoidderivate, verfahren zu deren herstellung und deren verwendung
EP1732908A1 (de) * 2004-04-07 2006-12-20 Cedarburg Pharmaceuticals, Inc. Verfahren und zwischenprodukte zur synthese von delta-9-tetrahydrocannabinol
US7323576B2 (en) 2004-10-01 2008-01-29 Alphora Research Inc. Synthetic route to dronabinol
TWI369203B (en) 2004-11-22 2012-08-01 Euro Celtique Sa Methods for purifying trans-(-)-△9-tetrahydrocannabinol and trans-(+)-△9-tetrahydrocannabinol
TWI366460B (en) * 2005-06-16 2012-06-21 Euro Celtique Sa Cannabinoid active pharmaceutical ingredient for improved dosage forms
DE102005028937B4 (de) * 2005-06-22 2009-07-23 Bionorica Ag Verfahren zur Herstellung von Dronabinol
NZ601567A (en) * 2005-09-29 2013-03-28 Albany Molecular Res Inc Process for production of delta-9-tetrahydrocannabinol
US8323211B2 (en) * 2006-06-01 2012-12-04 Daniel Larkin Sexually transmitted infection sampling device
EP3171871A4 (de) 2014-07-21 2018-02-28 Pharmaceutical Productions, Inc. Zusammensetzung mit fester dosierform für orale und sublinguale verabreichung von cannabinoiden
US10059683B2 (en) 2015-07-10 2018-08-28 Noramco, Inc. Process for the production of cannabidiol and delta-9-tetrahydrocannabinol
US10239808B1 (en) 2016-12-07 2019-03-26 Canopy Holdings, LLC Cannabis extracts
CA3056929A1 (en) 2017-03-24 2018-09-27 Trait Biosciences, Inc. High level in vivo biosynthesis and isolation of water-soluble cannabinoids in plant systems
CN111465700A (zh) 2017-07-11 2020-07-28 特征生物科学公司 在酵母和植物细胞悬浮培养物中产生水溶性大麻素化合物和材料组合物
US10640482B2 (en) 2017-07-21 2020-05-05 University Of South Florida Synthesis of cannabinoids
AU2019212486A1 (en) 2018-01-24 2019-08-29 Trait Biosciences, Inc. Systems and methods for enhancing trichome formation and density in
EP3745884A1 (de) 2018-01-31 2020-12-09 Canopy Holdings, Llc Hanfpulver
CA3112583A1 (en) 2018-07-09 2020-01-16 New Age Nanotech Llc Stabilized formulations of cannabinoid compositions
WO2020031179A1 (en) 2018-08-06 2020-02-13 Beetlebung Pharma Ltd. Methods for synthesis of cannabinoid compounds
WO2020051371A2 (en) 2018-09-05 2020-03-12 Noramco, Inc. Cannabidiol compositions having modified cannabinoid profiles
WO2020077153A1 (en) 2018-10-10 2020-04-16 Canopy Holdings, LLC Synthesis of cannabigerol
JP2022507668A (ja) * 2018-11-14 2022-01-18 エンバイオ リミテッド カンナビノイドを調製するための方法および化合物
CN111943813B (zh) 2019-05-17 2023-04-14 上海特化医药科技有限公司 大麻二酚类化合物的制备方法
CA3148950A1 (en) 2019-07-30 2021-02-04 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (A.R.O.), Volcani Center Methods of controlling cannabinoid synthesis in plants or cells and plants and cells produced thereby
WO2021139741A1 (zh) * 2020-01-08 2021-07-15 成都百裕制药股份有限公司 大麻二酚衍生物及其制备方法和在医药上的应用
US20230414639A1 (en) * 2020-11-15 2023-12-28 Technion Research And Development Foundation Limited Cannabinoids, pharmaceutical compositions comprising same and uses thereof
US11242328B1 (en) * 2021-02-25 2022-02-08 Acid Neutral Alkaline Laboratory Heterogeneous catalyst and method for preparation of aromatic tricyclic pyrans
US11352337B1 (en) * 2021-06-02 2022-06-07 Acid Neutral Alkaline Laboratory Zeolite catalyst and method for preparation of aromatic tricyclic pyrans
PL4124336T3 (pl) 2021-07-30 2024-02-26 Cannamedical Pharma Gmbh Plaster przezśluzówkowy obejmujący kannabinoid i/lub opioid

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US3656906A (en) * 1970-04-13 1972-04-18 Little Inc A Method for detecting and quantitating the presence of cannabinoids and analogs thereof in biological materials and resulting products
US4116979A (en) * 1975-06-23 1978-09-26 Sheehan Institute For Research, Inc. Process for the preparation of (-)-6a,10a-trans-6a,7,8,10a-tetrahydrodibenzo[b,d]-pyrans
HU194858B (en) * 1982-12-03 1988-03-28 Chinoin Gyogyszer Es Vegyeszet Process for producing dibenzo/b,d/pirane derivatives and pharmaceutical compositions containing them
US4758597A (en) * 1987-05-15 1988-07-19 University Patents, Inc. Carenadiol and derivatives

Also Published As

Publication number Publication date
EP0494665A1 (de) 1992-07-15
JP2637659B2 (ja) 1997-08-06
DE4100441A1 (de) 1992-07-16
ATE121066T1 (de) 1995-04-15
DK0494665T3 (da) 1995-08-28
ES2071351T3 (es) 1995-06-16
DE69201959T2 (de) 1995-08-24
US5227537A (en) 1993-07-13
JPH06340650A (ja) 1994-12-13
EP0494665B1 (de) 1995-04-12

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee