ATE121066T1 - Verfahren zur herstellung von 6,12-dihydro-6- hydroxy-cannabidiol und dessen anwendung zur herstellung von trans-delta-9- tetrahydrocannabinol. - Google Patents
Verfahren zur herstellung von 6,12-dihydro-6- hydroxy-cannabidiol und dessen anwendung zur herstellung von trans-delta-9- tetrahydrocannabinol.Info
- Publication number
- ATE121066T1 ATE121066T1 AT92100258T AT92100258T ATE121066T1 AT E121066 T1 ATE121066 T1 AT E121066T1 AT 92100258 T AT92100258 T AT 92100258T AT 92100258 T AT92100258 T AT 92100258T AT E121066 T1 ATE121066 T1 AT E121066T1
- Authority
- AT
- Austria
- Prior art keywords
- producing
- cannabidiol
- tetrahydrocannabinol
- dihydro
- delta
- Prior art date
Links
- 229950011318 cannabidiol Drugs 0.000 title abstract 2
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- IRMPFYJSHJGOPE-UHFFFAOYSA-N olivetol Chemical compound CCCCCC1=CC(O)=CC(O)=C1 IRMPFYJSHJGOPE-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/11—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
- C07C37/14—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms by addition reactions, i.e. reactions involving at least one carbon-to-carbon unsaturated bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4100441A DE4100441A1 (de) | 1991-01-09 | 1991-01-09 | Verfahren zur herstellung von 6,12-dihydro-6-hydroxy-cannabidiol und dessen verwendung zur herstellung von trans-delta-9-tetrahydrocannabinol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE121066T1 true ATE121066T1 (de) | 1995-04-15 |
Family
ID=6422735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92100258T ATE121066T1 (de) | 1991-01-09 | 1992-01-09 | Verfahren zur herstellung von 6,12-dihydro-6- hydroxy-cannabidiol und dessen anwendung zur herstellung von trans-delta-9- tetrahydrocannabinol. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5227537A (de) |
| EP (1) | EP0494665B1 (de) |
| JP (1) | JP2637659B2 (de) |
| AT (1) | ATE121066T1 (de) |
| DE (2) | DE4100441A1 (de) |
| DK (1) | DK0494665T3 (de) |
| ES (1) | ES2071351T3 (de) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5342971A (en) * | 1992-12-29 | 1994-08-30 | The Australian National University | Process for the preparation of dibenzo[b,d]pyrans |
| WO1999053917A1 (en) | 1998-04-21 | 1999-10-28 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Cannabinoids as antioxidants and neuroprotectants |
| AU3910700A (en) | 1999-03-22 | 2000-10-09 | Immugen Pharmaceuticals, Inc. | Treatment of immune diseases |
| US6566560B2 (en) | 1999-03-22 | 2003-05-20 | Immugen Pharmaceuticals, Inc. | Resorcinolic compounds |
| AU2002213429A1 (en) * | 2000-09-28 | 2002-04-08 | Immugen Pharmaceuticals, Inc. | Antiviral methods and compounds |
| WO2002026224A2 (en) * | 2000-09-28 | 2002-04-04 | Immugen Pharmaceuticals, Inc. | Methods and compounds for inhibiting eicosanoid metabolism and platelet aggregation |
| DE10051427C1 (de) * | 2000-10-17 | 2002-06-13 | Adam Mueller | Verfahren zur Herstellung eines Tetrahydrocannabinol- und Cannabidiol-haltigen Extraktes aus Cannabis-Pflanzenmaterial sowie Cannabis-Extrakte |
| DE10106024B4 (de) * | 2001-02-09 | 2004-10-14 | Thc Pharm Gmbh | Verfahren zur Herstellung von Dronabinol |
| AU2008200935B2 (en) * | 2001-02-05 | 2010-02-04 | Thc Pharm The Health Concept Gmbh | Method for the Production of Dronabinol |
| GB0112752D0 (en) * | 2001-05-25 | 2001-07-18 | Johnson Matthey Plc | Synthesis of cannabinoids |
| GB0112748D0 (en) * | 2001-05-25 | 2001-07-18 | Johnson Matthey Plc | Uncatalysed addition reactions |
| WO2003015700A2 (en) * | 2001-08-15 | 2003-02-27 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Novel vasoconstrictor cannabinoid analogs |
| US20030232101A1 (en) * | 2002-03-18 | 2003-12-18 | Immugen Pharmaceuticals, Inc. | Topical formulations of resorcinols and cannibinoids and methods of use |
| PL205945B1 (pl) * | 2002-08-14 | 2010-06-30 | Gw Pharma Ltd | Sposób ekstrakcji kannabinoidów z materiałów roślinnych oraz sposób wytwarzania kompozycji farmaceutycznej |
| US7344736B2 (en) * | 2002-08-14 | 2008-03-18 | Gw Pharma Limited | Extraction of pharmaceutically active components from plant materials |
| EP1613578A2 (de) * | 2003-04-10 | 2006-01-11 | Mallinckrodt Inc. | Olivetol-cyclodextrin-komplexe und regioselektives verfahren zur herstellung von delta 9-tetrahydrocannabinol |
| EP1633733B1 (de) * | 2003-05-20 | 2011-01-26 | The University of Tennessee Research Foundation | Cannabinoidderivate, verfahren zu deren herstellung und deren verwendung |
| EP1732908A1 (de) * | 2004-04-07 | 2006-12-20 | Cedarburg Pharmaceuticals, Inc. | Verfahren und zwischenprodukte zur synthese von delta-9-tetrahydrocannabinol |
| US7323576B2 (en) | 2004-10-01 | 2008-01-29 | Alphora Research Inc. | Synthetic route to dronabinol |
| TWI369203B (en) | 2004-11-22 | 2012-08-01 | Euro Celtique Sa | Methods for purifying trans-(-)-△9-tetrahydrocannabinol and trans-(+)-△9-tetrahydrocannabinol |
| TWI366460B (en) * | 2005-06-16 | 2012-06-21 | Euro Celtique Sa | Cannabinoid active pharmaceutical ingredient for improved dosage forms |
| DE102005028937B4 (de) * | 2005-06-22 | 2009-07-23 | Bionorica Ag | Verfahren zur Herstellung von Dronabinol |
| NZ601567A (en) * | 2005-09-29 | 2013-03-28 | Albany Molecular Res Inc | Process for production of delta-9-tetrahydrocannabinol |
| US8323211B2 (en) * | 2006-06-01 | 2012-12-04 | Daniel Larkin | Sexually transmitted infection sampling device |
| EP3171871A4 (de) | 2014-07-21 | 2018-02-28 | Pharmaceutical Productions, Inc. | Zusammensetzung mit fester dosierform für orale und sublinguale verabreichung von cannabinoiden |
| US10059683B2 (en) | 2015-07-10 | 2018-08-28 | Noramco, Inc. | Process for the production of cannabidiol and delta-9-tetrahydrocannabinol |
| US10239808B1 (en) | 2016-12-07 | 2019-03-26 | Canopy Holdings, LLC | Cannabis extracts |
| CA3056929A1 (en) | 2017-03-24 | 2018-09-27 | Trait Biosciences, Inc. | High level in vivo biosynthesis and isolation of water-soluble cannabinoids in plant systems |
| CN111465700A (zh) | 2017-07-11 | 2020-07-28 | 特征生物科学公司 | 在酵母和植物细胞悬浮培养物中产生水溶性大麻素化合物和材料组合物 |
| US10640482B2 (en) | 2017-07-21 | 2020-05-05 | University Of South Florida | Synthesis of cannabinoids |
| AU2019212486A1 (en) | 2018-01-24 | 2019-08-29 | Trait Biosciences, Inc. | Systems and methods for enhancing trichome formation and density in |
| EP3745884A1 (de) | 2018-01-31 | 2020-12-09 | Canopy Holdings, Llc | Hanfpulver |
| CA3112583A1 (en) | 2018-07-09 | 2020-01-16 | New Age Nanotech Llc | Stabilized formulations of cannabinoid compositions |
| WO2020031179A1 (en) | 2018-08-06 | 2020-02-13 | Beetlebung Pharma Ltd. | Methods for synthesis of cannabinoid compounds |
| WO2020051371A2 (en) | 2018-09-05 | 2020-03-12 | Noramco, Inc. | Cannabidiol compositions having modified cannabinoid profiles |
| WO2020077153A1 (en) | 2018-10-10 | 2020-04-16 | Canopy Holdings, LLC | Synthesis of cannabigerol |
| JP2022507668A (ja) * | 2018-11-14 | 2022-01-18 | エンバイオ リミテッド | カンナビノイドを調製するための方法および化合物 |
| CN111943813B (zh) | 2019-05-17 | 2023-04-14 | 上海特化医药科技有限公司 | 大麻二酚类化合物的制备方法 |
| CA3148950A1 (en) | 2019-07-30 | 2021-02-04 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (A.R.O.), Volcani Center | Methods of controlling cannabinoid synthesis in plants or cells and plants and cells produced thereby |
| WO2021139741A1 (zh) * | 2020-01-08 | 2021-07-15 | 成都百裕制药股份有限公司 | 大麻二酚衍生物及其制备方法和在医药上的应用 |
| US20230414639A1 (en) * | 2020-11-15 | 2023-12-28 | Technion Research And Development Foundation Limited | Cannabinoids, pharmaceutical compositions comprising same and uses thereof |
| US11242328B1 (en) * | 2021-02-25 | 2022-02-08 | Acid Neutral Alkaline Laboratory | Heterogeneous catalyst and method for preparation of aromatic tricyclic pyrans |
| US11352337B1 (en) * | 2021-06-02 | 2022-06-07 | Acid Neutral Alkaline Laboratory | Zeolite catalyst and method for preparation of aromatic tricyclic pyrans |
| PL4124336T3 (pl) | 2021-07-30 | 2024-02-26 | Cannamedical Pharma Gmbh | Plaster przezśluzówkowy obejmujący kannabinoid i/lub opioid |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3656906A (en) * | 1970-04-13 | 1972-04-18 | Little Inc A | Method for detecting and quantitating the presence of cannabinoids and analogs thereof in biological materials and resulting products |
| US4116979A (en) * | 1975-06-23 | 1978-09-26 | Sheehan Institute For Research, Inc. | Process for the preparation of (-)-6a,10a-trans-6a,7,8,10a-tetrahydrodibenzo[b,d]-pyrans |
| HU194858B (en) * | 1982-12-03 | 1988-03-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing dibenzo/b,d/pirane derivatives and pharmaceutical compositions containing them |
| US4758597A (en) * | 1987-05-15 | 1988-07-19 | University Patents, Inc. | Carenadiol and derivatives |
-
1991
- 1991-01-09 DE DE4100441A patent/DE4100441A1/de not_active Withdrawn
-
1992
- 1992-01-08 US US07/818,040 patent/US5227537A/en not_active Expired - Fee Related
- 1992-01-09 ES ES92100258T patent/ES2071351T3/es not_active Expired - Lifetime
- 1992-01-09 DK DK92100258.0T patent/DK0494665T3/da active
- 1992-01-09 DE DE69201959T patent/DE69201959T2/de not_active Expired - Fee Related
- 1992-01-09 EP EP92100258A patent/EP0494665B1/de not_active Expired - Lifetime
- 1992-01-09 AT AT92100258T patent/ATE121066T1/de not_active IP Right Cessation
- 1992-01-09 JP JP4002315A patent/JP2637659B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0494665A1 (de) | 1992-07-15 |
| JP2637659B2 (ja) | 1997-08-06 |
| DE4100441A1 (de) | 1992-07-16 |
| DK0494665T3 (da) | 1995-08-28 |
| ES2071351T3 (es) | 1995-06-16 |
| DE69201959D1 (de) | 1995-05-18 |
| DE69201959T2 (de) | 1995-08-24 |
| US5227537A (en) | 1993-07-13 |
| JPH06340650A (ja) | 1994-12-13 |
| EP0494665B1 (de) | 1995-04-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |