DE69400032D1 - Verfahren zur Herstellung von R-Aminocarnitin und S-Aminocarnitin. - Google Patents

Verfahren zur Herstellung von R-Aminocarnitin und S-Aminocarnitin.

Info

Publication number
DE69400032D1
DE69400032D1 DE69400032T DE69400032T DE69400032D1 DE 69400032 D1 DE69400032 D1 DE 69400032D1 DE 69400032 T DE69400032 T DE 69400032T DE 69400032 T DE69400032 T DE 69400032T DE 69400032 D1 DE69400032 D1 DE 69400032D1
Authority
DE
Germany
Prior art keywords
aminocarnitine
preparation
azidocarnitine
methanesulfonylcarnitine
lactone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69400032T
Other languages
English (en)
Other versions
DE69400032T2 (de
Inventor
Fabio Giannessi
Roberto Castagnani
Angelis Francesco De
Maria Ornella Tinti
Domenico Misiti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Application granted granted Critical
Publication of DE69400032D1 publication Critical patent/DE69400032D1/de
Publication of DE69400032T2 publication Critical patent/DE69400032T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
DE69400032T 1993-07-29 1994-07-13 Verfahren zur Herstellung von R-Aminocarnitin und S-Aminocarnitin. Expired - Lifetime DE69400032T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM930502A IT1261489B (it) 1993-07-29 1993-07-29 Procedimento per la produzione di r amminocarnitina e s amminocarnitina.

Publications (2)

Publication Number Publication Date
DE69400032D1 true DE69400032D1 (de) 1996-01-04
DE69400032T2 DE69400032T2 (de) 1996-04-18

Family

ID=11401885

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69400032T Expired - Lifetime DE69400032T2 (de) 1993-07-29 1994-07-13 Verfahren zur Herstellung von R-Aminocarnitin und S-Aminocarnitin.

Country Status (10)

Country Link
US (1) US5532409A (de)
EP (1) EP0636603B1 (de)
JP (1) JP3550423B2 (de)
AT (1) ATE130597T1 (de)
DE (1) DE69400032T2 (de)
DK (1) DK0636603T3 (de)
ES (1) ES2081230T3 (de)
GR (1) GR3018197T3 (de)
HK (1) HK1005860A1 (de)
IT (1) IT1261489B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1261828B (it) 1993-07-14 1996-06-03 Sigma Tau Ind Farmaceuti Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.
IT1276207B1 (it) * 1995-09-29 1997-10-27 Sigma Tau Ind Farmaceuti Procedimento per la preparazione del (s)-b-idrossi-gamma- butirrolattone
IT1297120B1 (it) * 1997-12-16 1999-08-03 Sigma Tau Ind Farmaceuti Procedimento per la produzione di (r)-3-idrossi-4-butirrolattone utile nella preparazione della (r)-carnitina
IT1299182B1 (it) 1998-05-29 2000-02-29 Sigma Tau Ind Farmaceuti Procedimento chimico per la sintesi stereoselettiva della r-(-)- carnitina.
IT1306162B1 (it) * 1999-06-30 2001-05-30 Sigma Tau Ind Farmaceuti Sintesi di (r) e (s)-amminocarnitina e di suoi derivati a partire daacido d e l-aspartico.
US6822115B2 (en) 1999-06-30 2004-11-23 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
IT1306184B1 (it) 1999-08-05 2001-05-30 Sigma Tau Ind Farmaceuti Nitrilossi derivati della (r) e (s)-carnitina.
ITRM20010456A1 (it) * 2001-07-26 2003-01-27 Sigma Tau Ind Farmaceuti Procedimento per la preparazione di (r)- o (s)- amminocarnitina sale interno, dei suoi sali e dei suoi derivati.
US7776915B2 (en) * 2005-03-24 2010-08-17 Tracie Martyn International, Llc Topical formulations and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3105082A (en) * 1960-12-02 1963-09-24 Dow Chemical Co Synthesis of amino acids
US4521432A (en) * 1981-11-26 1985-06-04 Takeda Chemical Industries, Ltd. Physiologically active substance FA-5859, its derivative, their production and use
DE3476656D1 (en) * 1983-05-25 1989-03-16 Takeda Chemical Industries Ltd Derivatives of beta-amino-gamma-trimethylammonio-butyrate, their production and use
IT1205758B (it) * 1987-03-18 1989-03-31 Sigma Tau Ind Farmaceuti Procedimento per la produzione di (-) n-acetil ammino carnitina e di (+) n-acetil ammino carnitina
IT1231751B (it) * 1989-04-12 1991-12-21 Sigma Tau Ind Farmaceuti Procedimento per la produzione di r(+) amminocarnitina e s(-) amminocarnitina

Also Published As

Publication number Publication date
DK0636603T3 (da) 1995-12-18
HK1005860A1 (en) 1999-01-29
IT1261489B (it) 1996-05-23
ITRM930502A0 (it) 1993-07-29
US5532409A (en) 1996-07-02
GR3018197T3 (en) 1996-02-29
ES2081230T3 (es) 1996-02-16
EP0636603A1 (de) 1995-02-01
ATE130597T1 (de) 1995-12-15
JP3550423B2 (ja) 2004-08-04
EP0636603B1 (de) 1995-11-22
JPH0770017A (ja) 1995-03-14
DE69400032T2 (de) 1996-04-18
ITRM930502A1 (it) 1995-01-29

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