IT1306162B1 - Sintesi di (r) e (s)-amminocarnitina e di suoi derivati a partire daacido d e l-aspartico. - Google Patents

Sintesi di (r) e (s)-amminocarnitina e di suoi derivati a partire daacido d e l-aspartico.

Info

Publication number
IT1306162B1
IT1306162B1 IT1999RM000418A ITRM990418A IT1306162B1 IT 1306162 B1 IT1306162 B1 IT 1306162B1 IT 1999RM000418 A IT1999RM000418 A IT 1999RM000418A IT RM990418 A ITRM990418 A IT RM990418A IT 1306162 B1 IT1306162 B1 IT 1306162B1
Authority
IT
Italy
Prior art keywords
aminocarnitine
derivatives
aspartic acid
solvents
possibility
Prior art date
Application number
IT1999RM000418A
Other languages
English (en)
Inventor
Fabio Giannessi
Uomo Natalina Dell
Maria Ornella Tinti
Angelis Franceso De
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of ITRM990418A0 publication Critical patent/ITRM990418A0/it
Priority to IT1999RM000418A priority Critical patent/IT1306162B1/it
Priority to PT00944218T priority patent/PT1194398E/pt
Priority to DK00944218T priority patent/DK1194398T3/da
Priority to ES00944218T priority patent/ES2204644T3/es
Priority to AU58448/00A priority patent/AU5844800A/en
Priority to US10/018,794 priority patent/US6528684B1/en
Priority to DE60004850T priority patent/DE60004850T2/de
Priority to AT00944218T priority patent/ATE248141T1/de
Priority to PCT/IT2000/000258 priority patent/WO2001002341A1/en
Priority to EP00944218A priority patent/EP1194398B1/en
Publication of ITRM990418A1 publication Critical patent/ITRM990418A1/it
Application granted granted Critical
Publication of IT1306162B1 publication Critical patent/IT1306162B1/it
Priority to US10/338,045 priority patent/US20030153783A1/en
Priority to US10/372,627 priority patent/US6822115B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
IT1999RM000418A 1999-06-30 1999-06-30 Sintesi di (r) e (s)-amminocarnitina e di suoi derivati a partire daacido d e l-aspartico. IT1306162B1 (it)

Priority Applications (12)

Application Number Priority Date Filing Date Title
IT1999RM000418A IT1306162B1 (it) 1999-06-30 1999-06-30 Sintesi di (r) e (s)-amminocarnitina e di suoi derivati a partire daacido d e l-aspartico.
DE60004850T DE60004850T2 (de) 1999-06-30 2000-06-23 Verfahren zur herstellung von (r) und (s)-aminocarnitin und deren derivative aus d- und l-aspargin säure
PCT/IT2000/000258 WO2001002341A1 (en) 1999-06-30 2000-06-23 Synthesis of (r) and (s)-aminocarnitine and their derivatives starting from d- and l-aspartic acid
ES00944218T ES2204644T3 (es) 1999-06-30 2000-06-23 Sintesis de (r) y (s)-aminocarnitina y sus derivados comenzando apartir de acido d-aspartico y l-aspartico.
AU58448/00A AU5844800A (en) 1999-06-30 2000-06-23 Synthesis of (r) and (s)-aminocarnitine and their derivatives starting from d- and l-aspartic acid
US10/018,794 US6528684B1 (en) 1999-06-30 2000-06-23 Synthesis of (R) and (S) -aminocarnitine and their derivatives starting from D- and L-aspartic acid
PT00944218T PT1194398E (pt) 1999-06-30 2000-06-23 Sintese de aminocarnitina (s) e (r) e dos seus derivados, a partir de acido aspartico l e d
AT00944218T ATE248141T1 (de) 1999-06-30 2000-06-23 Verfahren zur herstellung von (r) und (s)- aminocarnitin und deren derivative aus d- und l- aspargin säure
DK00944218T DK1194398T3 (da) 1999-06-30 2000-06-23 Syntese af (R)- og (S)-aminocarnitin og dets derivater med udgangspunkt i D- og L-asparginsyre
EP00944218A EP1194398B1 (en) 1999-06-30 2000-06-23 Synthesis of (r) and (s)-aminocarnitine and their derivatives starting from d- and l-aspartic acid
US10/338,045 US20030153783A1 (en) 1999-06-30 2003-01-08 Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
US10/372,627 US6822115B2 (en) 1999-06-30 2003-02-25 Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999RM000418A IT1306162B1 (it) 1999-06-30 1999-06-30 Sintesi di (r) e (s)-amminocarnitina e di suoi derivati a partire daacido d e l-aspartico.

Publications (3)

Publication Number Publication Date
ITRM990418A0 ITRM990418A0 (it) 1999-06-30
ITRM990418A1 ITRM990418A1 (it) 2000-12-30
IT1306162B1 true IT1306162B1 (it) 2001-05-30

Family

ID=11406859

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1999RM000418A IT1306162B1 (it) 1999-06-30 1999-06-30 Sintesi di (r) e (s)-amminocarnitina e di suoi derivati a partire daacido d e l-aspartico.

Country Status (10)

Country Link
US (1) US6528684B1 (it)
EP (1) EP1194398B1 (it)
AT (1) ATE248141T1 (it)
AU (1) AU5844800A (it)
DE (1) DE60004850T2 (it)
DK (1) DK1194398T3 (it)
ES (1) ES2204644T3 (it)
IT (1) IT1306162B1 (it)
PT (1) PT1194398E (it)
WO (1) WO2001002341A1 (it)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1299266B1 (it) * 1998-05-15 2000-02-29 Sigma Tau Ind Farmaceuti Inibitori reversibili della carnitina palmitoil trasferasi
US6822115B2 (en) * 1999-06-30 2004-11-23 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
US20030153783A1 (en) * 1999-06-30 2003-08-14 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
US7776915B2 (en) * 2005-03-24 2010-08-17 Tracie Martyn International, Llc Topical formulations and methods of use
US8410150B2 (en) * 2007-03-09 2013-04-02 University Health Network Inhibitors of carnitine palmitoyltransferase and treating cancer
CA2677049A1 (en) * 2007-08-01 2009-02-05 Sionex Corporation Cyclic inhibitors of carnitine palmitoyltransferase and treating cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1136945B (it) * 1981-03-18 1986-09-03 Anic Spa Processo per la preparazione di l-carnitina
IT1261489B (it) 1993-07-29 1996-05-23 Sigma Tau Ind Farmaceuti Procedimento per la produzione di r amminocarnitina e s amminocarnitina.

Also Published As

Publication number Publication date
US6528684B1 (en) 2003-03-04
DE60004850D1 (de) 2003-10-02
ATE248141T1 (de) 2003-09-15
EP1194398B1 (en) 2003-08-27
WO2001002341A1 (en) 2001-01-11
EP1194398A1 (en) 2002-04-10
ITRM990418A1 (it) 2000-12-30
ES2204644T3 (es) 2004-05-01
DK1194398T3 (da) 2003-12-22
PT1194398E (pt) 2004-01-30
DE60004850T2 (de) 2004-05-27
ITRM990418A0 (it) 1999-06-30
AU5844800A (en) 2001-01-22

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