ATE248141T1 - Verfahren zur herstellung von (r) und (s)- aminocarnitin und deren derivative aus d- und l- aspargin säure - Google Patents
Verfahren zur herstellung von (r) und (s)- aminocarnitin und deren derivative aus d- und l- aspargin säureInfo
- Publication number
- ATE248141T1 ATE248141T1 AT00944218T AT00944218T ATE248141T1 AT E248141 T1 ATE248141 T1 AT E248141T1 AT 00944218 T AT00944218 T AT 00944218T AT 00944218 T AT00944218 T AT 00944218T AT E248141 T1 ATE248141 T1 AT E248141T1
- Authority
- AT
- Austria
- Prior art keywords
- aminocarnitine
- derivatives
- producing
- aspargic acid
- aspargic
- Prior art date
Links
- DAWBGYHPBBDHMQ-ZCFIWIBFSA-N (3r)-3-amino-4-(trimethylazaniumyl)butanoate Chemical compound C[N+](C)(C)C[C@H](N)CC([O-])=O DAWBGYHPBBDHMQ-ZCFIWIBFSA-N 0.000 title abstract 3
- DAWBGYHPBBDHMQ-LURJTMIESA-N (3s)-3-amino-4-(trimethylazaniumyl)butanoate Chemical compound C[N+](C)(C)C[C@@H](N)CC([O-])=O DAWBGYHPBBDHMQ-LURJTMIESA-N 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- 235000003704 aspartic acid Nutrition 0.000 abstract 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000000376 reactant Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999RM000418A IT1306162B1 (it) | 1999-06-30 | 1999-06-30 | Sintesi di (r) e (s)-amminocarnitina e di suoi derivati a partire daacido d e l-aspartico. |
| PCT/IT2000/000258 WO2001002341A1 (en) | 1999-06-30 | 2000-06-23 | Synthesis of (r) and (s)-aminocarnitine and their derivatives starting from d- and l-aspartic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE248141T1 true ATE248141T1 (de) | 2003-09-15 |
Family
ID=11406859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00944218T ATE248141T1 (de) | 1999-06-30 | 2000-06-23 | Verfahren zur herstellung von (r) und (s)- aminocarnitin und deren derivative aus d- und l- aspargin säure |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6528684B1 (de) |
| EP (1) | EP1194398B1 (de) |
| AT (1) | ATE248141T1 (de) |
| AU (1) | AU5844800A (de) |
| DE (1) | DE60004850T2 (de) |
| DK (1) | DK1194398T3 (de) |
| ES (1) | ES2204644T3 (de) |
| IT (1) | IT1306162B1 (de) |
| PT (1) | PT1194398E (de) |
| WO (1) | WO2001002341A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1299266B1 (it) * | 1998-05-15 | 2000-02-29 | Sigma Tau Ind Farmaceuti | Inibitori reversibili della carnitina palmitoil trasferasi |
| US6822115B2 (en) * | 1999-06-30 | 2004-11-23 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid |
| US20030153783A1 (en) * | 1999-06-30 | 2003-08-14 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid |
| US7776915B2 (en) * | 2005-03-24 | 2010-08-17 | Tracie Martyn International, Llc | Topical formulations and methods of use |
| US8410150B2 (en) * | 2007-03-09 | 2013-04-02 | University Health Network | Inhibitors of carnitine palmitoyltransferase and treating cancer |
| CA2677049A1 (en) * | 2007-08-01 | 2009-02-05 | Sionex Corporation | Cyclic inhibitors of carnitine palmitoyltransferase and treating cancer |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1136945B (it) * | 1981-03-18 | 1986-09-03 | Anic Spa | Processo per la preparazione di l-carnitina |
| IT1261489B (it) | 1993-07-29 | 1996-05-23 | Sigma Tau Ind Farmaceuti | Procedimento per la produzione di r amminocarnitina e s amminocarnitina. |
-
1999
- 1999-06-30 IT IT1999RM000418A patent/IT1306162B1/it active
-
2000
- 2000-06-23 DK DK00944218T patent/DK1194398T3/da active
- 2000-06-23 EP EP00944218A patent/EP1194398B1/de not_active Expired - Lifetime
- 2000-06-23 US US10/018,794 patent/US6528684B1/en not_active Expired - Fee Related
- 2000-06-23 DE DE60004850T patent/DE60004850T2/de not_active Expired - Lifetime
- 2000-06-23 WO PCT/IT2000/000258 patent/WO2001002341A1/en not_active Ceased
- 2000-06-23 AU AU58448/00A patent/AU5844800A/en not_active Abandoned
- 2000-06-23 PT PT00944218T patent/PT1194398E/pt unknown
- 2000-06-23 AT AT00944218T patent/ATE248141T1/de not_active IP Right Cessation
- 2000-06-23 ES ES00944218T patent/ES2204644T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2204644T3 (es) | 2004-05-01 |
| WO2001002341A1 (en) | 2001-01-11 |
| DE60004850T2 (de) | 2004-05-27 |
| ITRM990418A0 (it) | 1999-06-30 |
| DE60004850D1 (de) | 2003-10-02 |
| AU5844800A (en) | 2001-01-22 |
| US6528684B1 (en) | 2003-03-04 |
| EP1194398B1 (de) | 2003-08-27 |
| EP1194398A1 (de) | 2002-04-10 |
| DK1194398T3 (da) | 2003-12-22 |
| IT1306162B1 (it) | 2001-05-30 |
| PT1194398E (pt) | 2004-01-30 |
| ITRM990418A1 (it) | 2000-12-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1194398 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |