DE69530592D1 - Verfahren zur herstellung von (+/-) calanolide a und zwischenprodukte dafür - Google Patents

Verfahren zur herstellung von (+/-) calanolide a und zwischenprodukte dafür

Info

Publication number
DE69530592D1
DE69530592D1 DE69530592T DE69530592T DE69530592D1 DE 69530592 D1 DE69530592 D1 DE 69530592D1 DE 69530592 T DE69530592 T DE 69530592T DE 69530592 T DE69530592 T DE 69530592T DE 69530592 D1 DE69530592 D1 DE 69530592D1
Authority
DE
Germany
Prior art keywords
calanolide
producing
intermediate products
products therefor
therefor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69530592T
Other languages
English (en)
Other versions
DE69530592T2 (de
Inventor
Michael T Flavin
Ze-Qi Xu
John D Rizzo
Alla Kucherenko
Albert Khilevich
Kivovich Sheinkman
Vilayphone Wilaychack
Lin Lin
Wei Chen
William Boulanger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sarawak MediChem Pharmaceuticals Inc
Original Assignee
Sarawak MediChem Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sarawak MediChem Pharmaceuticals Inc filed Critical Sarawak MediChem Pharmaceuticals Inc
Publication of DE69530592D1 publication Critical patent/DE69530592D1/de
Application granted granted Critical
Publication of DE69530592T2 publication Critical patent/DE69530592T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69530592T 1994-08-03 1995-08-02 Verfahren zur herstellung von (+/-) calanolide a und zwischenprodukte dafür Expired - Lifetime DE69530592T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US285655 1994-08-03
US08/285,655 US5489697A (en) 1994-08-03 1994-08-03 Method for the preparation of (+)-calanolide A and intermediates thereof
PCT/US1995/009804 WO1996004263A1 (en) 1994-08-03 1995-08-02 Method for the preparation of (±)-calanolide a and intermediates thereof

Publications (2)

Publication Number Publication Date
DE69530592D1 true DE69530592D1 (de) 2003-06-05
DE69530592T2 DE69530592T2 (de) 2004-03-18

Family

ID=23095160

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69530592T Expired - Lifetime DE69530592T2 (de) 1994-08-03 1995-08-02 Verfahren zur herstellung von (+/-) calanolide a und zwischenprodukte dafür

Country Status (9)

Country Link
US (1) US5489697A (de)
EP (3) EP0775130B1 (de)
JP (1) JP3043813B2 (de)
AT (1) ATE239008T1 (de)
AU (1) AU704247B2 (de)
CA (1) CA2196656C (de)
DE (1) DE69530592T2 (de)
MY (1) MY118279A (de)
WO (1) WO1996004263A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6774141B1 (en) 1992-03-31 2004-08-10 The United States Of America As Represented By The Secretary Of Health And Human Services Calanolide and related antiviral compounds, compositions, and uses thereof
AU5958394A (en) * 1992-12-23 1994-07-19 Smithkline Beecham Corporation Coumarin derivatives as retroviral inhibitors
US6277879B1 (en) 1994-08-03 2001-08-21 Sarawak Medichem Pharmaceuticals, Inc. Calanolide analogues and methods of their use
IL139080A0 (en) * 1998-04-17 2001-11-25 Parker Hughes Inst Btx inhibitors and methods for their indentification and use
US6303652B1 (en) 1998-08-21 2001-10-16 Hughes Institute BTK inhibitors and methods for their identification and use
US6306897B1 (en) 1999-03-19 2001-10-23 Parker Hughes Institute Calanolides for inhibiting BTK
WO2000064903A2 (en) 1999-04-26 2000-11-02 Sarawak Medichem Pharmaceuticals, Inc. Methods for preparing antiviral calanolide compounds
JP2002193971A (ja) * 2000-12-22 2002-07-10 Kuraray Co Ltd カラノリドａおよびその中間体の製造方法
EP1379529A2 (de) 2001-03-16 2004-01-14 Sarawak Medichem Pharmaceuticals, Inc. Pyranocoumarin verbindungen als neue pharmakophore mit anti-tb activität
WO2003070159A2 (en) * 2001-11-16 2003-08-28 Sarawak Medichem Pharmaceuticals Novel coumarin and chromene compounds and methods of treating or preventing viral infections
AU2003211734A1 (en) * 2002-03-08 2003-09-22 Kuraray Co., Ltd. Intermediates for production of (+)-calanolide a, processes for production of the intermediates and process for producing (+)-calanolide a with the same
US6777562B1 (en) 2003-02-19 2004-08-17 Dow Global Technologies Inc. Preparation of a trans-calanolide ketone intermediate and chiral separation of calanolide alcohols to give racemic calanolide A
JP4485520B2 (ja) 2003-03-24 2010-06-23 エフ．ホフマン−ラ ロシュ アーゲー 逆転写酵素阻害剤としてのベンジル−ピリダジノン類
JP2005314260A (ja) * 2004-04-28 2005-11-10 Japan Science & Technology Agency フラボンｃ配糖体の製法
CA2574363A1 (en) * 2004-07-23 2006-02-02 Pharmacia & Upjohn Company Llc Enantioselective method for separating sustituted 2-trifluoromethyl-2h-chromene-3-carboxylic acid derivatives
EP1940781A1 (de) 2005-10-19 2008-07-09 F.Hoffmann-La Roche Ag Phenylacetamid-nnrt-inhibitoren
AU2007286345B2 (en) 2006-08-16 2012-03-08 F. Hoffmann-La Roche Ag Non-nucleoside reverse transcriptase inhibitors
WO2008071587A2 (en) 2006-12-13 2008-06-19 F. Hoffmann-La Roche Ag 2-(piperidin-4-yl)-4-phenoxy- or phenylamino-pyrimidine derivatives as non-nucleoside reverse transcriptase inhibitors
BRPI0811645A2 (pt) 2007-05-30 2014-11-11 Hoffmann La Roche Inibidores de transcriptase reversa de não-nucleosídeo
CA2704649C (en) * 2007-11-05 2015-02-17 Institute Of Mataria Medica, Chinese Academy Of Medical Sciences Tetracyclic dipyrano-coumarin compounds with anti-hiv and anti-mycobacterium tuberculosis activities
KR101610415B1 (ko) 2007-12-21 2016-04-07 에프. 호프만-라 로슈 아게 헤테로사이클릭 항바이러스 화합물
WO2011077100A1 (en) 2009-12-24 2011-06-30 Cipla Limited Antiretroviral composition
RU2458944C1 (ru) * 2011-03-15 2012-08-20 Государственное образовательное учреждение высшего профессионального образования Кемеровский технологический институт пищевой промышленности Способ получения коллодиевой пленки центробежным методом

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5958394A (en) * 1992-12-23 1994-07-19 Smithkline Beecham Corporation Coumarin derivatives as retroviral inhibitors

Also Published As

Publication number Publication date
CA2196656C (en) 2010-03-23
JPH09512829A (ja) 1997-12-22
US5489697A (en) 1996-02-06
EP0775130B1 (de) 2003-05-02
CA2196656A1 (en) 1996-02-15
EP1054007A3 (de) 2000-11-29
WO1996004263A1 (en) 1996-02-15
MY118279A (en) 2004-09-30
DE69530592T2 (de) 2004-03-18
MX9700782A (es) 1997-09-30
EP0775130A1 (de) 1997-05-28
ATE239008T1 (de) 2003-05-15
AU3274695A (en) 1996-03-04
EP1054007A2 (de) 2000-11-22
EP1308448A1 (de) 2003-05-07
JP3043813B2 (ja) 2000-05-22
AU704247B2 (en) 1999-04-15

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