WO2016056031A1 - Novel diol compounds synthesis and its use for formal synthesis of (2r, 3 s)-3-hydroxypipecolic acid - Google Patents
Novel diol compounds synthesis and its use for formal synthesis of (2r, 3 s)-3-hydroxypipecolic acid Download PDFInfo
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- WO2016056031A1 WO2016056031A1 PCT/IN2015/050131 IN2015050131W WO2016056031A1 WO 2016056031 A1 WO2016056031 A1 WO 2016056031A1 IN 2015050131 W IN2015050131 W IN 2015050131W WO 2016056031 A1 WO2016056031 A1 WO 2016056031A1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
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- the present invention relates to novel diol derivatives and a chiral pool process for their synthesis from D glucose thereof. Further, the present invention relates to a process for the synthesis of (2R, 3S)-3-hydroxypipecolic acid from D-glucose using chiral pool approach, wherein the D-glucose used is in enantiomerically pure form.
- the 3-hydroxy pipecolic acid is a non proteinogenic cyclic a-amino acid. It is used in the preparation of conformationally restricted peptides and ligands binding studies. It is a constituent of many natural as well as synthetic biologically active compounds.
- the biological activities of piperidines vary with the position and nature of substituent on the ring. Both cis as well as trans isomers are structural units found in diverse natural products.
- the hydroxy pipecolic acid framework is target of several synthetic efforts. Synthetic chemists are interested in this structural motif because of its presence in compounds with diverse biological activities. They are of pivotal importance to medicinal chemistry and organic synthesis.
- US 6528538 B l discloses compounds having the following general formula for the treatment of dyslipidemia, atherosclerosis and diabetes;
- US 5594153 A discloses a process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-CoA reductase inhibiting compounds.
- the 1,3 dioxane derivatives does not lead to diols but it gives acyclic hydroxyl compounds.
- US 5,103,024 discloses a process which starts with (4R-cis)-l,l-dimethylethyl 6- hydroxymethyl-2,2-dimethyl-l,3-dioxane-4-acetate and derives the desired substance therefrom by two steps, namely conversion to an arylsulfonate and cyanation.
- the starting material disclosed therein is expensive and a multistep synthetic process is required for the preparation of the startin material itself from commercially available materials.
- the key step in the overall synthesis is a highly regioselective reductive cleavage of benzylidene acetal leading to (2R,3S)-l-tert.-butoxycarbonyl-3- benzyloxypiperidine-2-methanol.
- This process involves the use of azide chemistry, hazardous and sensitive reagents like Lithium aluminium hydride, silyl hydride, diphenyl phosphoryl azide which makes it less preferable for scale up. Further, 13 steps are required to achieve final target compound with low overall yield.
- WO 2006030892 Al discloses a process for the production of NS-220 which is suitable for mass production on an industrial scale.
- the invention is constituted of (1) a process for the production of methyl cis-5-(4-chlorobutyl) -2-methyl-l,3-dioxane-2-carboxylate, characterized by hydrolyzing a cis/trans isomer mixture of methyl 5-(4- chlorobutyl)-2- methyl-l,3-dioxane-2-carboxylate in the presence of a base; (2) a process for the production of 4-methyl-N-(2-oxopropyl)benzamide, characterized by oxidizing 4-methyl-N-(2- hydroxypropyl)benzamide with 2,2,6, 6-tetra- methyl- 1-piperidinyloxyl radicals and sodium hypochlorite; and so on.
- the main object of present invention is to provide novel diol derivatives and a chiral pool process for their synthesis from D glucose thereof.
- Another object of the present invention relates to a process for the synthesis of (2R, 3S)-3- hydroxypipecolic acid from D-glucose using chiral pool approach, wherein the D-glucose used is in enantiomerically pure form.
- the present invention provides novel diol derivatives and a chiral pool process for their synthesis from D glucose thereof.
- the present invention provides a process for the synthesis of (2R, 3S)-3- hydroxypipecolic acid from D-glucose using chiral pool approach.
- the present invention provide novel diol derivatives of general formula I,
- R 2 OH, I I . N i l . I I
- R 3 I I . OH, I I . N i l ,
- R CH 2 Ph, A l ly l , I I . Hoc. CBz, COO Me
- the present invention provides chiral pool process for the synthesis of the compound of formula I from D glucose.
- the present invention provide a process for the synthesis of (2R, 35)-3-hydroxypipecolic acid from D-glucose using chiral pool approach, wherein the D- glucose used is in enantiomerically pure form.
- the D-glucose compound as used herein for the synthesis of (2R, 35)-3-hydroxypipecolic acid is prepared by below scheme 1 :
- the present invention provides a process for synthesis of (2R, 35)- 3-hydroxypipecolic acid from D-glucose, wherein said process comprises the following steps: a) Reacting D-glucose with paraldehyde to give mono acetal protected (17?)-(-)-4,6-0- ethylidene-D-glucose;
- step (b) Compound from step (a) is then subjected for cleavage with NaI0 4 to give (-)-2,4-0- ethylidene-D-erythrose;
- step (b) Stirring the compound of step (b) at room temperature with Ph 3 PCHCOOEt in presence of toluene to give a, ⁇ -unsaturated hydroxy ester;
- step (e) Reacting the compound of step (e) with methanesulphonyl chloride and triethyl amine to give obtain dimesylate compound;
- step (f) Cyclization of compound of step (f) is carried out by heating dimesylate compound in neat benzyl amine to give cyclized product;
- step (j) Treating compound of step (j) with acetic acid to afford the selectively deprotected free primary alcohol;
- the intermediate cis piperidine 2,6-diol used for the synthesis of (2R, 3S)-3- hydroxypipecolic acid is also prepared by using one pot synthesis from N-benzylated compound by carrying hydrogenation reaction in presence of dil.HCl followed by addition of boc anhydride to get this intermediate in good yields.
- the intermediate cis piperidine 2, 6-diol compound of formula 1 is prepared by one pot synthesis from N-benzylated compound by carrying hydrogenation reaction in presence of dil.HCl followed by addition of boc anh dride to get this intermediate in ood yields. Then (Boc)2°
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Abstract
The patent discloses novel diol derivatives of general formula I, [Formula should be inserted here] A chiral pool process for the synthesis of the compound of formula I from D glucose. Further, it discloses a process for the synthesis of (2R, 3S)-3-hydroxypipecolic acid from D- glucose using chiral pool approach, wherein the D-glucose used is in enantiomerically pure form.
Description
NOVEL DIOL COMPOUNDS SYNTHESIS AND ITS USE FOR FORMAL SYNTHESIS OF (2R, 35)-3-HYDROXYPIPECOLIC ACID
FIELD OF THE INVENTION
The present invention relates to novel diol derivatives and a chiral pool process for their synthesis from D glucose thereof. Further, the present invention relates to a process for the synthesis of (2R, 3S)-3-hydroxypipecolic acid from D-glucose using chiral pool approach, wherein the D-glucose used is in enantiomerically pure form. BACKGROUND AND PRIOR ART OF THE INVENTION
The 3-hydroxy pipecolic acid is a non proteinogenic cyclic a-amino acid. It is used in the preparation of conformationally restricted peptides and ligands binding studies. It is a constituent of many natural as well as synthetic biologically active compounds. The biological activities of piperidines vary with the position and nature of substituent on the ring. Both cis as well as trans isomers are structural units found in diverse natural products. The hydroxy pipecolic acid framework is target of several synthetic efforts. Synthetic chemists are interested in this structural motif because of its presence in compounds with diverse biological activities. They are of pivotal importance to medicinal chemistry and organic synthesis.
In view of their great significance, a number of synthetic strategies have been devoted to the stereoselective synthesis of these chiral piperidines. These syntheses utilized both chiral pool and asymmetric routes. In chiral pool approaches, carbohydrates and non-carbohydrate sources are used for their syntheses. Carbohydrates are ideally suited to the preparation of single isomer of piperidines.
US 6528538 B l discloses compounds having the following general formula for the treatment of dyslipidemia, atherosclerosis and diabetes;
where X, Y=CH2, O, S, Ra (Ra=H, alkyl, aryl, etc.); R=H, alkyl, cycloalkyl, etc.;R =H, alkyl, hydroxyalkyl,— (CH2)t-COORc where t=0-6 & Rc represents H or alkyl group, etc.; R2 & R3=H, alkyl, cycloalkyl, (C6-Cio)aryl, (C6-Cio)aryl(Ci-C7)alkyl, 3-10 membered optionally
substituted heterocyclic group etc.; or R2 & R3 optionally form a chain— (CH2)ri(rl=2-5), etc.; R4-R7=H, alkyl, (un)substituted aryl, etc. It further relates to method for the synthesis of racemic compounds which is not useful in the synthesis of diols and pipecolic acids.
US 5594153 A discloses a process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-CoA reductase inhibiting compounds. The 1,3 dioxane derivatives does not lead to diols but it gives acyclic hydroxyl compounds.
US 5,103,024 discloses a process which starts with (4R-cis)-l,l-dimethylethyl 6- hydroxymethyl-2,2-dimethyl-l,3-dioxane-4-acetate and derives the desired substance therefrom by two steps, namely conversion to an arylsulfonate and cyanation. However, the starting material disclosed therein is expensive and a multistep synthetic process is required for the preparation of the startin material itself from commercially available materials.
CH3
X
Article titled "Chiron Approach to the Synthesis of (25, 3 ?)-3-Hydroxypipecolic Acid and (2R, 3 ?)-3-Hydroxy-2-hydroxymethylpiperidine from D-Glucose" by Dilip D. Dhavale et al. in J. Org. Chem., 2008, 73 (9), pp 3619-3622 reports the first chiron approach from d- glucose for the total synthesis of (25, 3 ?)-3-hydroxypipecolic acid. This is a long synthetic route which involves azide chemistry wherein scalability is an issue, reaction conditions are sensitive and not practical on higher scale.
Article titled, "A regioselective reductive cleavage of benzylidene acetal: Stereoselective synthesis of N-Boc-protected cis-(2R,3S)-3-hydroxypipecolic acid" by Kumar, Ponminor Senthil; Baskaran, Sundarababu in Tetrahedron Letters (2009), 50(26), 3489-3492 reports a stereoselective synthesis of N-Boc-protected cis-(2R,3S)-3-hydroxypipecolic acid, starting
from D-glucose. The key step in the overall synthesis is a highly regioselective reductive cleavage of benzylidene acetal leading to (2R,3S)-l-tert.-butoxycarbonyl-3- benzyloxypiperidine-2-methanol. This process involves the use of azide chemistry, hazardous and sensitive reagents like Lithium aluminium hydride, silyl hydride, diphenyl phosphoryl azide which makes it less preferable for scale up. Further, 13 steps are required to achieve final target compound with low overall yield.
Article titled "An efficient stereoselective and stereodivergent synthesis of (2R,3R)- and (2 ?,35)-3-hydroxypipecolic acids" by Jourdant et al. in Tetrahedron Letters, 2000, 41 (36), pp 7033-7036 reports a synthetic route to both cis and trans isomers 15 and 13 linear steps respectively from L-serine.
Article titled, "A convenient formal synthesis of (25,35)-3-hydroxy pipecolic acid" by Subhash P. Chavan in Tetrahedron: Asymmetry Volume 22, Issue 5, 2011, 587-590 reports a convenient synthesis of (25,35)-3-hydroxy pipecolic acid starting from inexpensive and easily available l-(+)-tartaric acid.
Article titled, "Stereoselective Syntheses of 1-Pipecolic Acid and (25,35)-3-Hydroxypipecolic Acid from a Chiral N-Imino-2-phenyl-l,2-dihydropyridine Intermediate" by Alexandre Lemire and Andre B. Charette in J. Org. Chem., 2010, 75 (6), pp 2077-2080 reports a. stereoselective synthesis of 1-pipecolic acid and (25,35)-3-hydroxypipecolic acid were achieved from a chiral N-imino-2-phenyl-l,2-dihydropyridine intermediate. The 3-hydroxy substituent of the latter amino acid was introduced by hetero-Diels- Alder reaction of singlet oxygen with the 1,2-dihydropyridine.
Article titled, "5,5-Bis(hydroxymethyl)-2-phenyl-l,3-dioxane" in Acta Cryst. (2008). E64, ol536 by Y.-M. Luo, X.-M. Liu, X.-Y. Yuan, M. Zhang and S. W. Ng reports the title compound, Ci2Hi604, wherein the 1,3-dioxane ring adopts a chair conformation; the 2-phenyl substitutent occupies an equatorial position. Adjacent molecules are linked by 0-H, , eO hydrogen bonds into a chain.
Article titled,"m-Dioxanes and Other Cyclic Acetals" by CHRISTIAN S. RONDESTVEDT Jr. in . Org. Chem., 1961, 26 (7), pp 2247-2253 reports an extensive series of substituted m- Dioxanes.
WO 2006030892 Al discloses a process for the production of NS-220 which is suitable for mass production on an industrial scale. The invention is constituted of (1) a process for the production of methyl cis-5-(4-chlorobutyl) -2-methyl-l,3-dioxane-2-carboxylate, characterized by hydrolyzing a cis/trans isomer mixture of methyl 5-(4- chlorobutyl)-2- methyl-l,3-dioxane-2-carboxylate in the presence of a base; (2) a process for the production of 4-methyl-N-(2-oxopropyl)benzamide, characterized by oxidizing 4-methyl-N-(2- hydroxypropyl)benzamide with 2,2,6, 6-tetra- methyl- 1-piperidinyloxyl radicals and sodium hypochlorite; and so on.
In literature there are number of syntheses reported. These synthesis have various drawbacks such as use of costly harmful metals, expensive starting material, lengthy synthetic routes which reduces over all yield of 3-hydroxy pipecolic acid.
Therefore there is need to develop a process for the synthesis of 3-hydroxy pipecolic acid which is short, efficient, scalable and with minimum purifications required, which successfully over coming these drawbacks. OBJECTIVE OF THE INVENTION
The main object of present invention is to provide novel diol derivatives and a chiral pool process for their synthesis from D glucose thereof.
Another object of the present invention relates to a process for the synthesis of (2R, 3S)-3- hydroxypipecolic acid from D-glucose using chiral pool approach, wherein the D-glucose used is in enantiomerically pure form.
SUMMARY OF THE INVENTION
Accordingly, the present invention provides novel diol derivatives and a chiral pool process for their synthesis from D glucose thereof.
Further, the present invention provides a process for the synthesis of (2R, 3S)-3- hydroxypipecolic acid from D-glucose using chiral pool approach.
In an aspect of present invention is to provides a simple reaction sequences, azide free, improved process for the synthesis of (2R, 3S)-3-hydroxypipecolic acid from D-glucose with over all yield in the range of 20-26 %. DETAILED DESCRIPTION OF THE INVENTION
The invention will now be described in detail in connection with certain preferred and optional embodiments, so that various aspects thereof may be more fully understood and appreciated.
In an embodiment, the present invention provide novel diol derivatives of general formula I,
R2 = OH, I I . N i l . I I
R3 = I I . OH, I I . N i l ,
R , =R , = -CH2CH2CH2NR4
R ,= CH2Ph, A l ly l , I I . Hoc. CBz, COO Me
Formula I
In another embodiment, the present invention provides chiral pool process for the synthesis of the compound of formula I from D glucose.
In yet another embodiment, the present invention provide a process for the synthesis of (2R, 35)-3-hydroxypipecolic acid from D-glucose using chiral pool approach, wherein the D- glucose used is in enantiomerically pure form.
The D-glucose compound as used herein for the synthesis of (2R, 35)-3-hydroxypipecolic acid is prepared by below scheme 1 :
D glucose 4
Scheme: 1
In a preferred embodiment, the present invention provides a process for synthesis of (2R, 35)- 3-hydroxypipecolic acid from D-glucose, wherein said process comprises the following steps: a) Reacting D-glucose with paraldehyde to give mono acetal protected (17?)-(-)-4,6-0- ethylidene-D-glucose;
b) Compound from step (a) is then subjected for cleavage with NaI04 to give (-)-2,4-0- ethylidene-D-erythrose;
c) Stirring the compound of step (b) at room temperature with Ph3PCHCOOEt in presence of toluene to give a, ^-unsaturated hydroxy ester;
d) Reduction of a, ^-unsaturated hydroxy ester by treatment with LiBr or LiCl and NaBH4 in THF: Water (1: 1) at ambient temperature to give allyl alcohol;
e) Hydrogenation of allyl alcohol of step (d) with Pd/C in methanol in hydrogen atmosphere to give the saturated compound 1,5 diol;
f) Reacting the compound of step (e) with methanesulphonyl chloride and triethyl amine to give obtain dimesylate compound;
g) Cyclization of compound of step (f) is carried out by heating dimesylate compound in neat benzyl amine to give cyclized product;
h) Hydrogenation of compound of step (g) in the presence of Boc anhydride and Pd/C to give N-debenzylation-N-Boc formation;
i) The N-boc piperidine from step (h) deprotected with PTSA in methanol and purified by recrystalization to get the target intermediate cis piperidine 2,6-diol in quantitative yield;
j) Adding t-BuMe2SiCl and imidazole to a solution of compound of step (i) in DMF followed by stirring at 40°C for 12 h to obtain (2R,3R)-tert-Butyl 3-(tert- butyldimethylsilyloxy)-2- ((tert-butyldimethylsilyloxy)methyl)piperidine- 1 - carboxylate;
k) Treating compound of step (j) with acetic acid to afford the selectively deprotected free primary alcohol;
1) Adding solution mixture of NaI04 in CH3CN/CC14/H20 and RuCl3.H20 to a solution of compound of step (k) in CH3CN followed by stirring at room temperature for 30 min to obtain (2S,3R)-N-tert-Butoxycarbonyl-3-hydroxypipecolic Acid; m) Heating the compound of step (1) in HC1 at 70 °C for 2 h to obtain (2S,3R)-3-
Hydroxypipecolic Acid Hydrochloride.
The above process for the synthesis of (2R, 35)-3-hydroxypipecolic acid compound of formula 12 is shown below in scheme 2.
11 12
Scheme 2
Scheme2. Reagents and conditions a) Ref.
1 ; b) NaI04, Water, 3 h, 97%; c) Ph3PCHCOOEt DCM, rt, 6 h, 87%; d) i) NaBH4 , LiCl, THF:water (1: 1), 12 h, ii) H2, Pd/C, MeOH, 60 psi, 3 h, 96%; e) MsClJEA, DCM, 0 °C, 30 min; f) BnNH2, heat, 2 h, 90%; g) H2, Pd/C, Boc20, MeOH, 60 Psi, 6 h; h) PTSA, MeOH, 3
h, rt, 91%; i) TBSC1, TEA, DMAP, DCM, 12 h, 86%; j) AcOH:H20:THF, 94%; k) RuCl3 (Cat.), NaI04, MeCN:CCl4:H20; 1) 6N HC1, 70 °C, 2 h.
The intermediate cis piperidine 2,6-diol used for the synthesis of (2R, 3S)-3- hydroxypipecolic acid is also prepared by using one pot synthesis from N-benzylated compound by carrying hydrogenation reaction in presence of dil.HCl followed by addition of boc anhydride to get this intermediate in good yields.
The process for synthesis of intermediate cis piperidine 2,6 diol compound of formula 1 is as shown in scheme
Scheme: 3
The following examples, which include preferred embodiments, will serve to illustrate the practice of this invention, it being understood that the particulars shown are by way of example and for purpose of illustrative discussion of preferred embodiments of the invention. EXAMPLES
Example 1:
Synthesis intermediate diol (1):
Synthesis of (2R, 35)-3-hydroxypipecolic acid began with mono acetal protection of glucose to obtain (17?)-(-)-4, 6-O-ethylidene-D-glucose in 65% yield which was then subjected for cleavage with NaI04 to afford (_)-2, 4-O-ethylidene-D-erythrose in almost quantitative yield. The two-carbon Wittig homologation of (-)-2,4-0-ethylidene-D-erythrose with Ph3PCHCOOEt by stirring in DCM afforded a, ?-unsaturated hydroxy ester in 7:3 trans/ cis ratio in good yield. Reduction of a, ^-unsaturated hydroxy ester by treatment with LiBr or LiCl and NaBH4 in THF: Water (1: 1) at ambient temperature. Allyl alcohol formed during reduction was hydrogenated with Pd/C in methanol in hydrogen atmosphere which give the saturated compound 1,5 diol in 96% yield. This 1, 5 diol compound is subjected for mesylation by treating it with methanesulphonyl chloride and triethyl amine in DCM at 0 °C for 0.5 h to obtain dimesylate compound. This mesylate derivative is used for further cycloamination without purification. Cyclization was carried out by heating dimesylate compound in neat benzyl amine at 90 °C for 2 h to afford cyclized product in 90% yield. This cyclized benzylated piperidine was hydrogenated with Pd/C in methanol at 60 psi and
concomitant boc protection which led to one-pot N-debenzylation-N-Boc formation. The N- boc piperidine was obtained in almost quantitative yield which is deprotected with PTSA in methanol and purified by recrystalization to get the target intermediate in quantitative yield. Example 2:
Ethyl (E)-3-((2R,45,5R)-5-hydroxy-2-methyl-l,3-dioxan-4-yl)acrylate (6):
The crude aldehyde 3 (1.12 g, 7.87 mmol) was dissolved in DCM (100 mL) and to this solution Ph3PCHC02Et (3 g, 8.66 mmol) was added. The reaction mixture was stirred at room temperature for 4
h. Completion of reaction was monitored on TLC. After completion of reaction, solvent was removed under reduced pressure and the crude product was purified using silica gel coloumn chromatography to furnish the a, ?-unsaturated ester 6 (1.7 g, 87% ) as a colorless solid. Rf (ethyl acetate: pet. ether/2:3): 0.3
Yield: 87%
Molecular formula: CioHi6Os;
Molecular weight: 216.2310
IR: 3453, 2988, 2932, 1718, 1662, 1447 cm"1
Optical rotation: [a] ^ : -41.45 ( c = 0.5, chloroform)
1H NMR (400 MHz, CDC13+CC14): δ 1.31 (t, / = 7.2 Hz, 3 H), 1.36 (d, = 5.0 Hz, 3 H), 2.68 (br. s., 1 H), 3.44 (q, = 10.5 Hz, 1 H), 3.48 - 3.55 (m, 1 H), 3.98 (ddd, = 9.0, 4.6, 1.5 Hz, 1 H), 4.13 (dd, = 10.4, 4.6 Hz, 1 H), 4.21 (q, = 7.2 Hz, 2 H), 4.73 (q, = 5.0 Hz, 1 H), 6.14 (dd, = 15.8, 1.6 Hz, 1 H), 7.08 (dd, = 15.8, 4.5 Hz, 1 H).
13C NMR (100 MHz, CDCI3+CCI4): δ 14.29, 20.45, 60.62, 65.23, 70.71, 80.04, 98.78, 122.19, 143.68, 166.50.
HRMS: calcd for Ci0Hi6O5Na 239.0895 found 239.0890 [M+Na]+.
(2R,45,5R)-4-(3-hydroxypropyl)-2-methyl-l,3-dioxan-5-ol (2):
addition by saturated NH4C1 solution at 0 °C and again stirred for 10 min. Evaporation of the solvent furnished a residue which was extracted with ethyl acetate (3x8 mL). The combined organic layer was washed with brine (7 mL) and dried over anhydrous Na2S04, filtered and concentrated under reduced pressure. The crude residue was dissolved in methanol. To this
solution catalytic Pd/C was added. This reaction mixture was stirred under hydrogen gas pressure. After 3 h, catalyst was filtered off. Methanol was eavaporated under reduced pressure. The residue was purified by a silica gel column chromatography using ethyl acetate/hexane (1: 1) as eluent furnished the reduced 1,5-diol compound 2 (790 mg, 97%) as a colorless liquid. Rf (ethyl acetate: pet. ether/3 :2): 0.2.
Molecular formula: Formula: C8Hi604
Molecular Weight: 176.21
Yield: 94%.
Optical rotation: [a]^ : -45.45 (c = 1.02, chloroform).
IR (CHC13): 3390, 2992; 1652 cm"1.
1H NMR (400 MHz, CDC13): δ 1.30 (d, J = 5.0 Hz, 3 H), 1.47 - 1.68 (m, 2 H), 1.69 - 1.83 (m, 1 H), 1.89 - 2.06 (m, 1 H), 3.26 - 3.48 (m, 3 H), 3.57 - 3.76 (m, 3 H), 4.05 (dd, J = 10.5, 5.0 Hz, 1 H), 4.29 (br. s., 1 H), 4.65 (q, = 5.0 Hz, 1 H).
13C NMR (100 MHz, CDC13): δ 20.39, 27.70, 28.03, 62.18, 65.12, 70.71, 81.15, 98.88.
HRMS: calcd for C8Hi604Na: 199.0946; found 199.0942 [M+Na]+.
(2R,4a5,8a5)-5-Benzyl-2-methylhexahydro-4H-[l,3]dioxino[5,4-b]pyridine(7)
A solution of 1,5-diol 2 (400 mg, 2.27 mmol) in dry CH2C12 (5 mL), and
Et3N (1.37g, 13.63 mmol) was cooled to 0 °C. Subsequently mesyl
chloride (780 mg, 6.81 mmol) was added and the mixture was stirred for 30 min at the same temperature. Progress of reaction was monitored by TLC. After completion of the reaction, it was quenched by addition of 5 mL of aqueous solution of NaHC03 and the organic layer was washed with water (2 x 5 mL), followed by brine (5 mL). The organic layer was dried over NaS04, filtered and concentrated in vacuo. The residue of dimesylate was used as such for further reaction witout purification.
The dimesylate (300 mg, 0.617 mmol) was dissolved in benzylamine (5 mL) and stirred at 90 °C for 2 h. After completion of reaction (monitored by TLC), 10 mL of IN HC1 was added and extracted with DCM (3 x 10 mL). The organic layer was washed with saturated aqueous NaHC03 (15 mL) and brine (10 mL), dried over NaS04, concentrated in vacuo and the crude product purified by silica gel column chromatography (Hexane-EtOAc = 9: 1) to yield 7 (215 mg, 90%) as a colorless oil. 7 (ethyl acetate: pet. ether/2:3): 0.5.
Chemical Formula: C15H21NO2
Molecular Weight: 247.33
Yield: 90%.
Optical rotation: [a] ^ : -37 (c=1.036, chloroform)
1H NMR (200 MHz, CDC13+CC14): δ 1.40 - 1.44 (m, 3 H), 1.88 - 2.23 (m, 6 H), 2.95 (dd, J = 10.6, 2.1 Hz, 1 H), 3.59 (d, J = 14.1 Hz, 1 H), 3.68 (dd, = 12.8, 2.3 Hz, 1 H), 3.79 - 3.90 (m, 1 H), 4.05 (d, J = 14.1 Hz, 1 H), 4.58 (dt, = 12.8, 0.7 Hz, 1 H), 4.80 (q, J = 5.1 Hz, 1 H), 7.15 - 7.44 (m, 5 H).
13C NMR (50 MHz, CDCI3+CCI4): δ 19.66, 20.91, 29.93, 51.84, 56.20, 57.05, 67.25, 73.44, 99.41, 126.96, 127.99, 129.30, 136.65.
HRMS: calcd for C15H22NO2: 248.1651 ; found: 248.1645 [M+Na]+.
tert-Butyl(2/f,4a5,8a5)-2-methylhexahydro-5H-[l,3]dioxino[5,4-b]pyridine-5- carboxylate (8):
To the solution of N-benzyl piperidine 7 (0.250 g, 0.546 mmol) in methanol (20 mL, 9: 1) was added boc anhydride (0.17 g, 0.65 mmol) and catalytic Pd/C. The reaction mixture was stirred under hydrogen gas atmoshphere at
60 psi pressure for 8 h. After completion of the reaction (monitored by TLC), the reaction mixture was filtered on celite. The solvent was removed under reduced pressure to afford crude N-boc protected compound 8. The residue was purified by flash silica gel column chromatography in 10% ethyl acetate in pet. ether to give compound 8 (0.118 g, 94%) as colorless thick syrup. 7 (ethyl acetate: pet. ether/l :3): 0.5.
Molecular formula: Ci3H23N04 Molecular weight: 257.32
Yield: 94%.
25
Optical rotation: [a] ^ : -32 ( c = 1.05, chloroform) IR (CHCI3): 2979, 1671, 757 cm"1.
1H NMR (500 MHz, CDCI3+CCI4): δ 1.31 (d, J = 4.9 Hz, 3 H), 1.44 (s, 9 H), 1.51 - 2.08 (m, 4 H), 3.36 (br. s., 1 H), 3.48 (td, = 12.5, 6.1 Hz, 1 H), 3.72 (dd, = 12.4, 2.3 Hz, 1 H), 3.94 (dd, = 13.1, 7.9 Hz, 1 H), 4.01 (q, = 3.4 Hz, 1 H), 4.25 (d, = 12.2 Hz, 1 H), 4.67 (q, = 5.0 Hz, 1 H).
13C NMR (125 MHz, CDCI3+CCI4): δ 18.75, 21.35, 24.17, 28.52, 38.10, 49.12, 70.50, 71.13, 79.37, 79.40, 98.36, 154.93. HRMS: calcd for Ci3H23N04Na: 280.1519; found: 280.1525 [M+Na]+.
tert-butyl (2S,3S)-3-hydroxy-2-(hydroxymethyl)piperidine-l-carboxylate(l)
To a solution of ieri-butyl (2 ?,4aS,8aS)-2-methylhexahydro-5H- [l,3]dioxino[5,4-b]pyridine-5-carboxylate 8 (1.7 g, 6.88 mmol) in MeOH
(20 mL) was added p-TSA (130 mg, 0.69 mmol) at 0 °C and the mixture stirred for 2 h at room temperature. After completion of the reaction (monitored by TLC), the reaction mixture was neutralized with NaHC03 and the organic layer and aqueous layers were separated. Aqueous layer was extracted with EtOAc (3 x 50 mL). The combined organic layers were washed with brine, dried over anhydrous Na2S04, filtered and concentrated to dryness under reduced pressure. Purification by column chromatography using petroleum ether: ethyl acetate (1: 1) as eluent afforded 1.55 g compound as a white solid in 96% yield. Purification can also be carried out by recrystalizing the compound 1 from pet ether by dissolving in it by addition of minimum amount of ethyl actetate. Rf (ethyl acetate: Pet. ether/2:3): 0.4.
Molecular formula: CnH2iN04 Molecular weight: 231.29 Yield: 96%.
MP: 115-117 °C Lit. 114-116 °C
Optical rotation: [<x]¾ : +24.2 (c: 1, MeOH); Lit.37 [<x]¾ : (c: 1.03, MeOH), [<x]¾ : +33.6 (c = 1.04, CHC13); Lit. [<x]¾ : +23.4 (c = 1, CHC13) IR (CHC13): I : 3407, 2935, 1668, 1423 cm"1
1H NMR (400 MHz, CDCI3+CCI4): δ 1.45 (s, 10 H), 1.55 - 1.77 (m, 2 H), 1.85 (d, 7 = 12.3 Hz, 1 H), 2.82 (br. s., 1 H), 3.36 (br. s, 2 H), 3.73 (dd, 7 = 11.2, 6.9 Hz, 1 H), 3.79 (br. s., 1 H), 3.87 - 3.96 (m, 1 H), 4.10 (dd, 7 = 11.2, 6.5 Hz, 1 H), 4.42 (q, 7 = 6.1 Hz, 1 H).
13C NMR (100 MHz, CDCI3+CCI4): δ 23.80, 28.34, 28.45, 39.76, 56.08, 59.26, 69.39, 80.26, 155.62.
HRMS: calcd for CnH2iN04Na: 254.1368; found:254.1363 [M+Na]+.
(25,35)-tert-Butyl3-((tert-butyldimethylsilyl)oxy)-2-(((tert-butyldimethylsilyl)oxy) methyl)piperidine- 1 -carboxylate (9) 15
To the solution of diol 1 (40 mg, 0.173 mmol ) in DCM (1 mL) TBDMSC1 (79 mg, 0.52 mmol), imidazole (71 mg, 0.10 mmol) and
DMAP (0.0173 mmol) was added under nitrogen. The mixture was stirred at room temperature for 12 h and diluted with DCM (3.0 mL). An aqueous solution saturated of NaHC03 (3.0 mL) was added and the product was extracted four times with DCM (3 mL). The organic layer was, dried over NaS04, filtered and concentrated in vacuo and the crude product purified by silica gel column chromatography (Hexane-EtOAc = 9: 1) to yield 9 (69 mg, 86%) as a colorless oil. 7 (ethyl acetate: Pet. ether/l:8): 0.3.
Molecular formula: C23H49N04Si2 Molecular weight: 459.81
Yield: 86%
Optical rotation: +14 (c 0.5, CHC13); ent-l: Lit. 15 -13:6 (c 0.5, CHC13); IR (CDC13): 2930, 1693, 756 cm"1.
1H NMR (400 MHz, CDCI3): δ 0.02 - 0.17 (m, 12 H), 0.79 - 1.00 (m, 18 H), 1.46 (s, 9 H), 1.53 - 1.86 (m, 4 H), 2.71 - 3.06 (m, 1 H), 3.58 - 4.09 (m, 4 H), 4.19 - 4.46 (m, 1 H).
13C NMR (100 MHz, CDC13): δ -5.4, -5.4, -5.0, -4.8, 18.1, 18.2, 24.2, 25.8, 25.9, 28.4, 29.6, 29.7, 37.3, 39.2, 55.8, 57.8, 58.1, 69.6, 79.1, 155.2.
Example 3:
Synthesis of (25,3/?)-N-tert-Butoxycarbonyl-3-hydroxypipecolic Acid (11):
To a suspension of NaI04 (235 mg, 1.1 mmol) in
(4.8 mL; 1: 1: 10) was added RuCl3,H20 (11.4 mg, 0.055 mmol) in small portions, and the mixture was stirred at room temperature for 45 min. The resulting solution was added to the alcohol 10 (191 mg, 0.55 mmol) dissolved in CH3CN (3 mL), followed by the addition of a second portion of NaI04 (118 mg, 0.55 mmol). The resulting mixture was stirred at room temperature for 30 min and filtered through Celite, and the Celite layer was washed thoroughly with EtOAc. The combined filtrate was dried over Na2S04 and concentrated. The crude product thus obtained was purified by flash column chromatography (MeOH/CHCl3) 5:95 to 20:80) to yield the pure acid 11 (97 mg, 72%) as a semisolid.
Example 4:
Synthesis of (25, 3/?)-3-Hydroxypipecolic acid hydrochloride (12):
The Boc-protected acid 11 (78 mg, 0.32 mmol) was taken in 6 N HCl (10 mL) and heated at 70 °C for 2 h. The reaction mixture was cooled to room temperature and extracted once with CH2CI2 (10 mL) to remove any organic soluble impurities. Concentration of the aqueous layer under high vacuum followed by overnight drying under high vacuum afforded the product 12 as a light yellow solid (57 mg, quantitative).
Example 5:
Synthesis of cis piperidine 2,6 diol (1):
The intermediate cis piperidine 2, 6-diol compound of formula 1 is prepared by one pot synthesis from N-benzylated compound by carrying hydrogenation reaction in presence of dil.HCl followed by addition of boc anh dride to get this intermediate in ood yields.
Then (Boc)2°
To the solution of N-benzyl piperidine 7 (0.250 g, 0.546 mmol) in methanol - dil. HCl (20 mL, 9: 1), was added catalytic Pd/C and the reaction mixture was stirred under hydrogen gas atmoshphere at 60 psi pressure for 4 h. After completion of the reaction (monitored by TLC), the boc anhydride (0.17 g, 0.65 mmol) was added to this reaction mixture and stirred further for 2 h. The reaction mixture was filtered on celite. The solvent was removed under reduced pressure to afford crude N-boc protected compound 8. The product was purified by recrystalization. ADVANTAGES OF THE PRESENT INVENTION
Simple reaction sequence which is good for industrial production.
1) Azide-free reaction makes the process cheaper.
2) Improved over all yield good for large scale synthesis.
3) Easily available cheap staring material decreases the cost.
Claims
1. Compounds of formula I,
R2 - OH, H, NH, H
R3 = H, OH, H, NH2
R1=R3 = -CH2CH2CH2NR4
R4= CH2Ph, Allyl, H, Boc, CBz, COOMe
2. A process for the synthesis of compound of formula I as claimed in claim 1, wherein said process comprises of:
a. Reacting D-glucose with paraldehyde to give mono acetal protected (l'R)-(-)- 4,6-O-ethylidene-D-glucose at room temperature ( temperature range 20 °C to 50 °C for 3 days) compound from step (a) is then subjected for cleavage with NaI04( temperature range 0 °C to 10 °C for 3 to 5 h) to give (-)-2,4-0- ethylidene-D-erythrose;
b. Stirring the compound of step (b) at room temperature with Ph3PCHCOOEt in the presence of toluene/DCM ( temperature range 20 °C to 110 °C for 4 to 10 h) to give a, ^-unsaturated hydroxy ester;
c. Reduction of a, ^-unsaturated hydroxy ester by treatment with LiBr or LiCl and NaBH4 in THF: Water (1 : 1) ( temperature range 0 °C to 40 °C/ room temperature for 12 to 18 h) to give allyl alcohol;
d. Hydrogenation of allyl alcohol of step (d) with Pd/C in methanol in hydrogen atmosphere at 60 psi ( temperature range 20 °C to 40 °C for 2 to 4 h) to give the saturated compound of formula I.
3. The process as claimed in claim 2, wherein said process is used for the synthesis of (2R, 35)-3-hydroxypipecolic acid from D-glucose.
4. The process as claimed in claim 3, wherein said process comprises the steps of:
a) Reacting D-glucose with paraldehyde to give mono acetal protected (l'R)-(-)- 4,6-O-ethylidene-D-glucose;
b) Compound from step (a) is then subjected for cleavage with NaI04 to give (-)- 2,4-O-ethylidene-D-erythrose;
c) Stirring the compound of step (b) at room temperature( temperature range 20 °C to 40 °C for 4 to 10 h) with Ph3PCHCOOEt in presence of toluene/DCM to give a, ^-unsaturated hydroxy ester;
d) Reduction of a, ^-unsaturated hydroxy ester by treatment with LiBr or LiCl and NaBH4 in THF:Water (1 : 1) at ambient temperature ( temperature range - from 0 °C allowed to attain room range 20 °C to 40 °C) to give allyl alcohol; e) Hydrogenation of allyl alcohol of step (d) with Pd/C in methanol in hydrogen atmosphere (60 psi pressure and temperature range 20 °C to 40 °C for 2 to 4 h) to give the saturated compound 1,5 diol;
f) Reacting the compound of step (e) with methanesulphonyl chloride and triethyl amine to give obtain dimesylate compound ( temperature range 20 °C to 10 °C for 30 min to 60 min);
g) Cyclization of compound of step (f) is carried out by heating dimesylate compound in neat benzyl amine to give cyclized product ( temperature range 85 °C to 95 °C for 2-4 hours);
h) Hydrogenation of compound of step (g) in the presence of Boc anhydride and Pd/C to give N-debenzylation-N-Boc formation (60 psi pressure and temperature range 27 °C to 40 °C);
i) The N-boc piperidine from step (h) deprotected with PTSA in methanol ( temperature range 20 °C to 40 °C);
j) and purified by recrystalization to get the target intermediate cis piperidine
2,6-diol in quantitative yield;
k) Adding t-BuMe2SiCl and imidazole to a solution of compound of step (i) in
DMF followed by stirring at 20-40°C for 10 to 18 h to obtain {2R,3R)-tert-
Butyl 3-(tert-butyldimethylsilyloxy)-2- ((tert- butyldimethylsilyloxy)methyl)piperidine- 1 -carboxylate;
1) Treating compound of step (j) with acetic acid to afford the selectively deprotected free primary alcohol;
m) Adding solution mixture of NaI04 in CH3CN/CC14/H20 and RuCl .H20 to a solution of compound of step (k) in CH3CN followed by stirring at room
temperature ( range- 20 °C to 40 °C) for 30 to 60 min to obtain 2S,3R)-N-tert- B utoxycarbonyl- 3 -hydroxypipecolic Acid ;
n) Heating the compound of step (1) in HC1 at temperature range 60-80 °C for 2 to 4 h to obtain (25, 3 ?)-3-Hydroxypipecolic Acid Hydrochloride.
5. The process as claimed in claim 3, wherein the D-glucose used is in enantiomerically pure form.
6. The process as claimed in claim 4, wherein the temperature is in the range of 0 to 110 °C and overall yield is in the range of 20 to 26 %.
7. A one pot process for the synthesis of the cis piperidine 2,6-diol intermediate as claimed in step (i) of claim 6, wherein the said process comprises carrying hydrogenation reaction of N-benzylated compound in presence of dil.HCl at temperature 20 °C to 40 °C followed by addition of boc anhydride to obtain the desired product in good yields.
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