NO301588B1 - Fremgangsmåte og mellomprodukt for syntese av (4R-cis)-1,1-dimetyletyl-6-cyanometyl-2,2-dimetyl-1,3-dioksan-4-acetat - Google Patents

Fremgangsmåte og mellomprodukt for syntese av (4R-cis)-1,1-dimetyletyl-6-cyanometyl-2,2-dimetyl-1,3-dioksan-4-acetat

Info

Publication number
NO301588B1
NO301588B1 NO931421A NO931421A NO301588B1 NO 301588 B1 NO301588 B1 NO 301588B1 NO 931421 A NO931421 A NO 931421A NO 931421 A NO931421 A NO 931421A NO 301588 B1 NO301588 B1 NO 301588B1
Authority
NO
Norway
Prior art keywords
cyanomethyl
dimethylethyl
dioxane
cis
dimethyl
Prior art date
Application number
NO931421A
Other languages
English (en)
Other versions
NO931421D0 (no
NO931421L (no
Inventor
Alan Millar
Donald Eugene Butler
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of NO931421D0 publication Critical patent/NO931421D0/no
Publication of NO931421L publication Critical patent/NO931421L/no
Publication of NO301588B1 publication Critical patent/NO301588B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
NO931421A 1990-10-17 1993-04-16 Fremgangsmåte og mellomprodukt for syntese av (4R-cis)-1,1-dimetyletyl-6-cyanometyl-2,2-dimetyl-1,3-dioksan-4-acetat NO301588B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/599,521 US5103024A (en) 1990-10-17 1990-10-17 Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
PCT/US1991/006697 WO1992006968A1 (en) 1990-10-17 1991-09-11 Process for the synthesis of (4r-cis)-1,1-dimethylethyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate

Publications (3)

Publication Number Publication Date
NO931421D0 NO931421D0 (no) 1993-04-16
NO931421L NO931421L (no) 1993-06-16
NO301588B1 true NO301588B1 (no) 1997-11-17

Family

ID=24399962

Family Applications (1)

Application Number Title Priority Date Filing Date
NO931421A NO301588B1 (no) 1990-10-17 1993-04-16 Fremgangsmåte og mellomprodukt for syntese av (4R-cis)-1,1-dimetyletyl-6-cyanometyl-2,2-dimetyl-1,3-dioksan-4-acetat

Country Status (20)

Country Link
US (1) US5103024A (no)
EP (1) EP0553213B1 (no)
JP (1) JP3105923B2 (no)
KR (1) KR0166385B1 (no)
AT (1) ATE118772T1 (no)
AU (1) AU646311B2 (no)
CA (1) CA2092997C (no)
CZ (5) CZ282992B6 (no)
DE (1) DE69107622T2 (no)
DK (1) DK0553213T3 (no)
ES (1) ES2070519T3 (no)
FI (1) FI108539B (no)
HK (1) HK1005026A1 (no)
HU (2) HU213731B (no)
IE (1) IE62940B1 (no)
NO (1) NO301588B1 (no)
PT (1) PT99244B (no)
RU (1) RU2067580C1 (no)
SK (5) SK280941B6 (no)
WO (1) WO1992006968A1 (no)

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HRP960312B1 (en) 1995-07-17 2001-10-31 Warner Lambert Co NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS /R-(R*, R*)/-2-(4-FLUOROPHENYL)-"beta", "delta"-DIHYDROXY-5-PHENYL-4-/(PHENYLAMINO)CARBONYL/-1H-PYRROLE -1-HEPTANOIC ACID CALCIUM SALT (2 : 1)
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SI20814A (sl) 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
SI20848A (sl) 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
GEP20053546B (en) 2001-06-29 2005-06-10 Warner Lambert Co Crystalline Forms of 'R-(R*,R*)!-2-(4- Fluorophenyl)-Beta, Delta-Dihydroxy-5-(1-Methylethyl)-3-Phenyl-4-'Phenylamino) Carbonyl!-1H-Pyrrole-1-Heptanoic Acid Calcium Salt (2:1) (Atorvastatin)
GB0116212D0 (en) * 2001-07-03 2001-08-29 Avecia Ltd Process
IL159626A0 (en) 2001-07-30 2004-06-01 Reddys Lab Ltd Dr Crystalline forms of atorvastatin calcium and processes for the preparation thereof
US20030114497A1 (en) * 2001-07-31 2003-06-19 Laman Alani Pharmaceutical compositions of amlodipine and atorvastatin
CA2456095C (en) * 2001-08-31 2010-05-11 Morepen Laboratories Ltd. An improved process for the preparation of amorphous atorvastatin calcium salt (2:1)
HU227124B1 (en) * 2001-09-14 2010-07-28 Egis Gyogyszergyar Nyilvanosan Polymorphs of 1-pyrrole derivative, intermediate for the preparation of atorvastatin
UA77990C2 (en) * 2001-12-12 2007-02-15 Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
CZ296967B6 (cs) * 2002-02-01 2006-08-16 Zentiva, A.S. Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu)
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AU2003251523A1 (en) 2002-06-13 2003-12-31 Diversa Corporation Processes for making (r)-ethyl 4-cyano-3-hydroxybutyric acid
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KR100529703B1 (ko) * 2002-09-23 2005-11-17 임광민 키랄 중간체의 제조방법 및 그를 이용한 아토바스타틴의제조방법
HRP20020885B1 (en) * 2002-11-11 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
RS20050760A (sr) * 2003-04-14 2008-04-04 Warner-Lambert Company Llc., Postupak za izradu fenilamida 5-(4- fluorofenil)-1-(2-((2r, 4r)-4-hidroksi- 6-okso-tetrahidro-piran-2-il)etil)-2- izopropil-4-fenil-1h-pirol-3- karboksilne kiseline
US20050182125A1 (en) * 2003-05-16 2005-08-18 Ambit Biosciences Corporation Pyrrole compounds and uses thereof
WO2004110357A2 (en) * 2003-05-16 2004-12-23 Ambit Biosciences Corporation Heterocyclic compounds and uses thereof
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US7790197B2 (en) * 2003-06-09 2010-09-07 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
US7655692B2 (en) * 2003-06-12 2010-02-02 Pfizer Inc. Process for forming amorphous atorvastatin
US20050271717A1 (en) * 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
US20040253305A1 (en) * 2003-06-12 2004-12-16 Luner Paul E. Pharmaceutical compositions of atorvastatin
KR101113163B1 (ko) 2003-07-25 2012-02-17 브래드포드 파마 리미티드 스타틴, 특히 아토르바스타틴의 제조에 유용한 중간체화합물 및 그 제조방법
CN1852894A (zh) * 2003-09-17 2006-10-25 沃尼尔·朗伯有限责任公司 [R－(R*, R*)]－2－(4－氟苯基) －β,δ－二羟基－5－(1－甲基乙基) －3－苯基－4－[(苯基氨基)羰基] －1 H－吡咯－1－庚酸的结晶形式
CA2456430A1 (en) * 2004-01-28 2005-07-28 Brantford Chemicals Inc. Improved process for the preparation of amorphous atorvastatin calcium
DK1727795T3 (da) 2004-03-17 2012-04-16 Ranbaxy Lab Ltd Fremgangsmåde til fremstillingen af atorvastatin-calcium i amorf form
CA2562844A1 (en) * 2004-04-16 2005-10-27 Pfizer Products Inc. Process for forming amorphous atorvastatin calcium
EP3581564A1 (en) 2004-05-05 2019-12-18 Pfizer Products Inc. Diethylamine salt forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid
SI1771455T1 (sl) * 2004-07-16 2016-09-30 Lek Pharmaceuticals D.D. Oksidacijski razgradni produkti atorvastatin kalcija
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CA2578722C (en) * 2004-08-27 2010-02-02 Biocon Limited Process for atorvastatin calcium amorphous
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WO2006059224A1 (en) * 2004-12-02 2006-06-08 Warner-Lambert Company Llc Pharmaceutical compositions of amorphous atorvastatin and process for preparing same
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US20100113802A1 (en) * 2006-11-02 2010-05-06 Cadila Pharmaceuticals Limited Process for preparing amorphous atorvastatin hemi calcium salt and its itermediate
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WO2016056031A1 (en) 2014-10-08 2016-04-14 Council Of Scientific & Industrial Research Novel diol compounds synthesis and its use for formal synthesis of (2r, 3 s)-3-hydroxypipecolic acid
CN106008251A (zh) * 2016-05-19 2016-10-12 河南豫辰药业股份有限公司 一种2-苯甲撑-3-氧代-4-甲基-n-苯基戊酰胺的制备方法

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US4647576A (en) * 1984-09-24 1987-03-03 Warner-Lambert Company Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
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Also Published As

Publication number Publication date
SK280939B6 (sk) 2000-09-12
PT99244B (pt) 1999-04-30
HU9701183D0 (en) 1997-09-29
US5103024A (en) 1992-04-07
FI931680A (fi) 1993-04-14
IE62940B1 (en) 1995-03-08
EP0553213A1 (en) 1993-08-04
NO931421D0 (no) 1993-04-16
JP3105923B2 (ja) 2000-11-06
WO1992006968A1 (en) 1992-04-30
HU213731B (en) 1997-09-29
CZ282993B6 (cs) 1997-12-17
CZ124597A3 (en) 1997-12-17
CZ282994B6 (cs) 1997-12-17
CZ209495A3 (en) 1997-12-17
CZ282922B6 (cs) 1997-11-12
HU9301122D0 (en) 1993-08-30
HUT64049A (en) 1993-11-29
ATE118772T1 (de) 1995-03-15
CZ61493A3 (en) 1994-02-16
CZ124697A3 (en) 1997-12-17
NO931421L (no) 1993-06-16
CA2092997A1 (en) 1992-04-18
CA2092997C (en) 2002-05-14
KR930702328A (ko) 1993-09-08
HU219237B (en) 2001-03-28
IE913629A1 (en) 1992-04-22
FI931680A0 (fi) 1993-04-14
SK33993A3 (en) 1993-10-06
DE69107622T2 (de) 1995-07-06
KR0166385B1 (en) 1999-01-15
DK0553213T3 (da) 1995-07-17
SK280938B6 (sk) 2000-09-12
SK280941B6 (sk) 2000-09-12
PT99244A (pt) 1992-09-30
FI108539B (fi) 2002-02-15
AU8848091A (en) 1992-05-20
RU2067580C1 (ru) 1996-10-10
SK280942B6 (sk) 2000-09-12
ES2070519T3 (es) 1995-06-01
CZ283003B6 (cs) 1997-12-17
CZ124797A3 (en) 1997-12-17
HK1005026A1 (en) 1998-12-18
SK280940B6 (sk) 2000-09-12
AU646311B2 (en) 1994-02-17
DE69107622D1 (de) 1995-03-30
EP0553213B1 (en) 1995-02-22
CZ282992B6 (cs) 1997-12-17
JPH06502162A (ja) 1994-03-10

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