NO301588B1 - Fremgangsmåte og mellomprodukt for syntese av (4R-cis)-1,1-dimetyletyl-6-cyanometyl-2,2-dimetyl-1,3-dioksan-4-acetat - Google Patents

Fremgangsmåte og mellomprodukt for syntese av (4R-cis)-1,1-dimetyletyl-6-cyanometyl-2,2-dimetyl-1,3-dioksan-4-acetat

Info

Publication number
NO301588B1
NO301588B1 NO931421A NO931421A NO301588B1 NO 301588 B1 NO301588 B1 NO 301588B1 NO 931421 A NO931421 A NO 931421A NO 931421 A NO931421 A NO 931421A NO 301588 B1 NO301588 B1 NO 301588B1
Authority
NO
Norway
Prior art keywords
cyanomethyl
dimethylethyl
dioxane
cis
dimethyl
Prior art date
Application number
NO931421A
Other languages
English (en)
Other versions
NO931421D0 (no
NO931421L (no
Inventor
Alan Millar
Donald Eugene Butler
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of NO931421D0 publication Critical patent/NO931421D0/no
Publication of NO931421L publication Critical patent/NO931421L/no
Publication of NO301588B1 publication Critical patent/NO301588B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
NO931421A 1990-10-17 1993-04-16 Fremgangsmåte og mellomprodukt for syntese av (4R-cis)-1,1-dimetyletyl-6-cyanometyl-2,2-dimetyl-1,3-dioksan-4-acetat NO301588B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/599,521 US5103024A (en) 1990-10-17 1990-10-17 Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
PCT/US1991/006697 WO1992006968A1 (en) 1990-10-17 1991-09-11 Process for the synthesis of (4r-cis)-1,1-dimethylethyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate

Publications (3)

Publication Number Publication Date
NO931421D0 NO931421D0 (no) 1993-04-16
NO931421L NO931421L (no) 1993-06-16
NO301588B1 true NO301588B1 (no) 1997-11-17

Family

ID=24399962

Family Applications (1)

Application Number Title Priority Date Filing Date
NO931421A NO301588B1 (no) 1990-10-17 1993-04-16 Fremgangsmåte og mellomprodukt for syntese av (4R-cis)-1,1-dimetyletyl-6-cyanometyl-2,2-dimetyl-1,3-dioksan-4-acetat

Country Status (20)

Country Link
US (1) US5103024A (no)
EP (1) EP0553213B1 (no)
JP (1) JP3105923B2 (no)
KR (1) KR0166385B1 (no)
AT (1) ATE118772T1 (no)
AU (1) AU646311B2 (no)
CA (1) CA2092997C (no)
CZ (5) CZ282922B6 (no)
DE (1) DE69107622T2 (no)
DK (1) DK0553213T3 (no)
ES (1) ES2070519T3 (no)
FI (1) FI108539B (no)
HK (1) HK1005026A1 (no)
HU (2) HU219237B (no)
IE (1) IE62940B1 (no)
NO (1) NO301588B1 (no)
PT (1) PT99244B (no)
RU (1) RU2067580C1 (no)
SK (5) SK280940B6 (no)
WO (1) WO1992006968A1 (no)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5149837A (en) * 1988-02-22 1992-09-22 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5245047A (en) * 1988-02-22 1993-09-14 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5298627A (en) * 1993-03-03 1994-03-29 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
HRP960312B1 (en) 1995-07-17 2001-10-31 Warner Lambert Co NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS /R-(R*, R*)/-2-(4-FLUOROPHENYL)-"beta", "delta"-DIHYDROXY-5-PHENYL-4-/(PHENYLAMINO)CARBONYL/-1H-PYRROLE -1-HEPTANOIC ACID CALCIUM SALT (2 : 1)
US6087511A (en) * 1996-07-16 2000-07-11 Warner-Lambert Company Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid) calcium salt (2:1)
EP1077212B1 (en) * 1998-04-30 2003-08-20 Kaneka Corporation Process for producing 6-cyanomethyl-1,3-dioxane-4-acetic acid derivatives
HU227840B1 (en) * 1999-05-06 2012-05-02 Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag Intermediates of atorvastatin synthesis and process for producing them
IN191236B (no) 1999-05-25 2003-10-11 Ranbaxy Lab Ltd
US20040063969A1 (en) * 1999-10-18 2004-04-01 Egis Gyogyszergyar Rt. Process for the preparation of amorphous atorvastatin calcium
JP2003517039A (ja) * 1999-12-17 2003-05-20 ワーナー・ランバート・リサーチ・アンド・ディベロップメント・アイルランド・リミテッド 結晶質アトルバスタチンカルシウムの製造方法
ES2252088T3 (es) 1999-12-17 2006-05-16 Pfizer Science And Technology Ireland Limited Procedimiento de produccion a escala industrial de la hemisal de calcio de la atorvastatina trihidrato cristalina.
US7608445B1 (en) 1999-12-29 2009-10-27 Verenium Corporation Nitrilases, nucleic acids encoding them and methods for making and using them
US7300775B2 (en) 1999-12-29 2007-11-27 Verenium Corporation Methods for producing α-substituted carboxylic acids using nitrilases and strecker reagents
US7521216B2 (en) 1999-12-29 2009-04-21 Verenium Corporation Nitrilases and methods for making and using them
US20040014195A1 (en) * 1999-12-29 2004-01-22 Diversa Corporation Nitrilases, nucleic acids encoding them and methods for making and using them
JP3844112B2 (ja) 2000-08-23 2006-11-08 高砂香料工業株式会社 ３，５，６−トリヒドロキシヘキサン酸アンモニウム塩誘導体、及びその製造方法
EP1728785A1 (en) 2001-01-09 2006-12-06 Warner-Lambert Company LLC 7-[(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-pyrrol-1-yl]-heptanoic acid ester 3,5-dioxo-acetal
US6476235B2 (en) 2001-01-09 2002-11-05 Warner-Lambert Company Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
WO2002057229A1 (en) * 2001-01-19 2002-07-25 Biocon India Limited FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
SI20814A (sl) * 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
SI20848A (sl) 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
MXPA03010266A (es) 2001-06-29 2004-03-10 Warner Lambert Co Formas cristalinas de la sal de calcio del acido [r-(r*, r*)]-2 -(4-fluorofenil)-¦, d-dihidroxi-5 -(1-metiletil)-3 -fenil-4- [(fenilamino) carbonil ]-1h- pirrol-1-heptanoico (2:1) (atorvastatin).
GB0116212D0 (en) * 2001-07-03 2001-08-29 Avecia Ltd Process
JP2005500351A (ja) 2001-07-30 2005-01-06 ドクター・レディーズ・ラボラトリーズ・リミテッド 結晶形態ｖｉおよびｖｉｉのアトルバスタチンカルシウム
US20030114497A1 (en) * 2001-07-31 2003-06-19 Laman Alani Pharmaceutical compositions of amlodipine and atorvastatin
AU2001284385A1 (en) * 2001-08-31 2003-03-10 Morepen Laboratories Ltd. An improved process for the preparation of amorphous atorvastatin calcium salt (2:1)
HU227124B1 (en) * 2001-09-14 2010-07-28 Egis Gyogyszergyar Nyilvanosan Polymorphs of 1-pyrrole derivative, intermediate for the preparation of atorvastatin
UA77990C2 (en) * 2001-12-12 2007-02-15 Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
CZ296967B6 (cs) * 2002-02-01 2006-08-16 Zentiva, A.S. Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu)
DE10212492B4 (de) * 2002-03-21 2012-02-02 Daimler Ag Kolbenpumpe
AU2003251523A1 (en) * 2002-06-13 2003-12-31 Diversa Corporation Processes for making (r)-ethyl 4-cyano-3-hydroxybutyric acid
ES2287549T3 (es) * 2002-08-06 2007-12-16 Warner-Lambert Company Llc Procedimiento para preparar la fenilamida del acido 5-(4-fluorofenil)-1-(2-((2r,4r)-4-hidroxi-6-oxo-tetrahidropiran-2-il)etil)-2-isopropil-4-fenil-1h-pirrol-3-carboxilico.
CA2491051A1 (en) * 2002-09-03 2004-03-18 Morepen Laboratories Limited Atorvastatin calcium form vi or hydrates thereof
KR100529703B1 (ko) * 2002-09-23 2005-11-17 임광민 키랄 중간체의 제조방법 및 그를 이용한 아토바스타틴의제조방법
HRP20020885B1 (en) * 2002-11-11 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
AU2004228463A1 (en) * 2003-04-14 2004-10-21 Warner-Lambert Company Llc Process for preparing 5-(4-fluorophenyl)-1-[2-((R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
US20040248972A1 (en) * 2003-05-16 2004-12-09 Ambit Biosciences Corporation Compounds and uses thereof
US20050182125A1 (en) * 2003-05-16 2005-08-18 Ambit Biosciences Corporation Pyrrole compounds and uses thereof
WO2004110357A2 (en) * 2003-05-16 2004-12-23 Ambit Biosciences Corporation Heterocyclic compounds and uses thereof
US7790197B2 (en) * 2003-06-09 2010-09-07 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
US20040253305A1 (en) * 2003-06-12 2004-12-16 Luner Paul E. Pharmaceutical compositions of atorvastatin
US20050271717A1 (en) 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
US7655692B2 (en) * 2003-06-12 2010-02-02 Pfizer Inc. Process for forming amorphous atorvastatin
EP2522656A3 (en) 2003-07-25 2013-03-20 Redx Pharma Limited Process and Intermediate Compounds Useful in the Preparation of Statins, Particularly Atorvastatin
KR100781420B1 (ko) * 2003-09-17 2007-12-03 워너-램버트 캄파니 엘엘씨 [Ｒ-(Ｒ*,Ｒ*)]-2-(4-플루오로페닐)-β,δ-다이하이드록시-5-(1-메틸에틸)-3-페닐-4-[(페닐아미노)카보닐]-1Ｈ-피롤-1-헵탄산의 결정성 형태
CA2456430A1 (en) * 2004-01-28 2005-07-28 Brantford Chemicals Inc. Improved process for the preparation of amorphous atorvastatin calcium
SI1727795T1 (sl) 2004-03-17 2012-05-31 Ranbaxy Lab Ltd Postopek za pripravo atorvastatin kalcija v amorfni obliki
JP2007532622A (ja) * 2004-04-16 2007-11-15 ファイザー・プロダクツ・インク 非晶質アトルバスタチン・カルシウムの形成方法
BRPI0510713A (pt) 2004-05-05 2007-11-20 Pfizer Prod Inc formas de sal de ácido [r-(r*,r*)]-2-(4-fluorofenil)-beta, delta-diidróxi-5-(1-metiletil)-3-fenil-4-[(fenilamino)ca rbonil]-1h-pirrol-1- heptanóico
EP1771455B1 (en) * 2004-07-16 2016-05-11 LEK Pharmaceuticals d.d. Oxidative degradation products of atorvastatin calcium
WO2006011041A2 (en) 2004-07-20 2006-02-02 Warner-Lambert Company Llc Crystalline forms of (r-(r*))-2-(4-fluorophenyl)-beta, gamma-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1h-pyrrole-1-hept anoic acid calcium salt (2:1)
EP1784389A4 (en) * 2004-08-27 2009-03-25 Biocon Ltd PROCESS FOR THE PREPARATION OF AMORPHIC ATORVASTATIN CALCIUM
CN101048141A (zh) 2004-10-28 2007-10-03 沃尼尔·朗伯有限责任公司 形成非晶形的阿托伐他汀的方法
CA2588216A1 (en) 2004-11-22 2006-05-26 Dexcel Pharma Technologies Ltd. Stable atorvastatin formulations
US20090088465A1 (en) * 2004-12-02 2009-04-02 Stephen Craig Dyar Pharmaceutical Compositions of Amorphous Atorvastatin and Process for Preparing Same
JP2009507822A (ja) * 2005-09-09 2009-02-26 ファイザー・サイエンス・アンド・テクノロジー・アイルランド・リミテッド アトルバスタチン中間体の調製
ATE432276T1 (de) * 2005-09-09 2009-06-15 Pfizer Science & Tech Ltd Herstellung eines atorvastatin-zwischenprodukts
US20090216029A1 (en) * 2005-09-16 2009-08-27 Yatendra Kumar Process for the production of atorvastatin calcium in amorphous form
CA2547216A1 (en) 2005-09-21 2007-03-21 Renuka D. Reddy Process for annealing amorphous atorvastatin
ES2304335T3 (es) * 2005-11-21 2010-05-19 Warner-Lambert Company Llc Formas nuevas del acido (r-(r*,r*))-2-(4-fluorofenil)-b,b-dihidroxi-5-(1-metiletil)-3-fenil-4-((fenilamino)carbonil)1h-pirrol-1-heptanoico, de magnesio.
EP1810667A1 (en) 2006-01-20 2007-07-25 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition comprising amorphous atorvastatin
WO2008053312A2 (en) * 2006-11-02 2008-05-08 Cadila Pharmaceuticals Limited Process for preparing amorphous atorvastatin hemi calcium salt and its intermediate
US7834195B2 (en) * 2007-01-24 2010-11-16 Apotex Pharmachem Inc. Atorvastatin calcium propylene glycol solvates
WO2008106662A2 (en) 2007-03-01 2008-09-04 Verenium Corporation Nitrilases, nucleic acids encoding them and methods for making and using them
US20110142883A1 (en) * 2007-07-20 2011-06-16 Actavis Group Ptc Ehf Amorphous Coprecipitates of Atorvastatin Pharmaceutically Acceptable Salts
EP2075246A1 (en) 2007-12-27 2009-07-01 M. J. Institute of Research A process for preparation of amorphous form of atorvastatin hemi-calcium salt
US8115015B2 (en) * 2009-01-26 2012-02-14 Cadila Healthcare Limited Process for the preparation of amorphous atorvastatin calcium
WO2012032035A1 (en) 2010-09-09 2012-03-15 Dsm Sinochem Pharmaceuticals Netherlands B.V. Salts of 7-amino-3,5-dihydroxyheptanoic acid esters
MX2013015272A (es) 2011-07-01 2014-04-14 Dsm Sinochem Pharm Nl Bv Cristales micronizados.
WO2016056031A1 (en) 2014-10-08 2016-04-14 Council Of Scientific & Industrial Research Novel diol compounds synthesis and its use for formal synthesis of (2r, 3 s)-3-hydroxypipecolic acid
CN106008251A (zh) * 2016-05-19 2016-10-12 河南豫辰药业股份有限公司 一种2-苯甲撑-3-氧代-4-甲基-n-苯基戊酰胺的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647576A (en) * 1984-09-24 1987-03-03 Warner-Lambert Company Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US5003080A (en) * 1988-02-22 1991-03-26 Warner-Lambert Company Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis
US5093363A (en) * 1989-08-22 1992-03-03 Shionogi & Co., Ltd. 2,4,6-substituted phenol derivatives
DE3929913A1 (de) * 1989-09-08 1991-04-04 Hoechst Ag 4-hydroxytetrahydropyran-2-one sowie die entsprechenden dihydroxycarbonsaeurederivate, salze und ester, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate sowie vorprodukte

Also Published As

Publication number Publication date
SK280938B6 (sk) 2000-09-12
CZ124797A3 (en) 1997-12-17
EP0553213A1 (en) 1993-08-04
NO931421D0 (no) 1993-04-16
SK280941B6 (sk) 2000-09-12
SK280939B6 (sk) 2000-09-12
RU2067580C1 (ru) 1996-10-10
IE62940B1 (en) 1995-03-08
FI931680A0 (fi) 1993-04-14
FI108539B (fi) 2002-02-15
SK280942B6 (sk) 2000-09-12
HUT64049A (en) 1993-11-29
SK280940B6 (sk) 2000-09-12
FI931680A (fi) 1993-04-14
AU8848091A (en) 1992-05-20
CZ282922B6 (cs) 1997-11-12
CZ282994B6 (cs) 1997-12-17
CZ124697A3 (en) 1997-12-17
HU219237B (en) 2001-03-28
IE913629A1 (en) 1992-04-22
CZ209495A3 (en) 1997-12-17
HK1005026A1 (en) 1998-12-18
CA2092997A1 (en) 1992-04-18
EP0553213B1 (en) 1995-02-22
KR0166385B1 (en) 1999-01-15
DK0553213T3 (da) 1995-07-17
DE69107622D1 (de) 1995-03-30
JPH06502162A (ja) 1994-03-10
CZ61493A3 (en) 1994-02-16
US5103024A (en) 1992-04-07
DE69107622T2 (de) 1995-07-06
CZ282993B6 (cs) 1997-12-17
CA2092997C (en) 2002-05-14
SK33993A3 (en) 1993-10-06
HU9301122D0 (en) 1993-08-30
PT99244B (pt) 1999-04-30
PT99244A (pt) 1992-09-30
CZ282992B6 (cs) 1997-12-17
KR930702328A (ko) 1993-09-08
AU646311B2 (en) 1994-02-17
HU9701183D0 (en) 1997-09-29
ES2070519T3 (es) 1995-06-01
JP3105923B2 (ja) 2000-11-06
WO1992006968A1 (en) 1992-04-30
HU213731B (en) 1997-09-29
NO931421L (no) 1993-06-16
CZ283003B6 (cs) 1997-12-17
ATE118772T1 (de) 1995-03-15
CZ124597A3 (en) 1997-12-17

Similar Documents

Publication Publication Date Title
NO301588B1 (no) Fremgangsmåte og mellomprodukt for syntese av (4R-cis)-1,1-dimetyletyl-6-cyanometyl-2,2-dimetyl-1,3-dioksan-4-acetat
SE8001339L (sv) Antihyperkolesteraemiskt medel, monakolin k och framstellning derav
NZ195048A (en) Producing ethanol by continuous fermentation of polysaccharide-containing raw materials
EP0535928A3 (en) Process for producing intermediates for use in production of alkoxyiminoacetamides and intermediates to be used therein
NO951747D0 (no) Fremgangsmåte ved fremstilling av xylitol
DE2964401D1 (en) Process for the preparation of cyclohexenyl derivatives, and intermediates produced in the synthesis
DE3576952D1 (de) Verfahren zur herstellung von 4-phenyl-pyrrol-derivaten.
AU3214593A (en) A process for preparing 2-azaspiro-(4.4)-nonan-3-one, 2-azaspiro-(4.5)-decan-3-one and 2-azaspiro-(4.6)- undecan-3-one
IT1116897B (it) Intermedi per la sintesi di 4-demetossidaunobicina daunorubicina acri amicina e carminomicina
CA2076886A1 (en) Method for production of 2-amino-6-halogenopurine and synthesis intermediate therefor
GR1001125B (el) Μεθοδος δια την εις βιομηχανικη κλιμακα παραγωγην της βμυ 21502.
PL272024A1 (en) Method of obtaining novel derivative of 1,3-dioxane
DE69204755T2 (de) Herstellung von Alkansulfonamiden.
ATE138903T1 (de) Verfahren zur herstellung von substituierten vinylbenzolen
IT1158019B (it) Procedimento fermentativo per la produzione di 9-idrossi-3-osso-4,17(20)-pregnadien-20-carbossaldeide e prodotto ottenuto, utile in particolare per la sintesi di corticosteroidi
DE3061478D1 (en) Process for the preparation of cholestene derivatives and intermediates in this preparation
NO872670L (no) 4-benzyloksy-3-pyrrolin-2-on, fremstilling og anvendelse derav ved syntese av tetransyre.
ES2084084T3 (es) Procedimiento para la preparacion de derivados de ciclopropanonitrilo.
SU621723A1 (ru) Способ производства этилового спирта из крахмалосодержащего сырь
JPS5231059A (en) Preparation of oxybenzoylbenzoic acids
TH1208A (no)
EP0446373A4 (en) Novel method of producing oxetanocin derivative
JPS53119861A (en) Preparation of abietic acid 13-position substituted derivative

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees