ATE432276T1 - Herstellung eines atorvastatin-zwischenprodukts - Google Patents
Herstellung eines atorvastatin-zwischenproduktsInfo
- Publication number
- ATE432276T1 ATE432276T1 AT05777481T AT05777481T ATE432276T1 AT E432276 T1 ATE432276 T1 AT E432276T1 AT 05777481 T AT05777481 T AT 05777481T AT 05777481 T AT05777481 T AT 05777481T AT E432276 T1 ATE432276 T1 AT E432276T1
- Authority
- AT
- Austria
- Prior art keywords
- diol
- ester
- atorvastatin
- acid
- acetonide
- Prior art date
Links
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 title abstract 2
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 title abstract 2
- 229960005370 atorvastatin Drugs 0.000 title abstract 2
- -1 tert-butyl isopropylidene nitrile Chemical class 0.000 abstract 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 6
- OUCSEDFVYPBLLF-KAYWLYCHSA-N 5-(4-fluorophenyl)-1-[2-[(2r,4r)-4-hydroxy-6-oxooxan-2-yl]ethyl]-n,4-diphenyl-2-propan-2-ylpyrrole-3-carboxamide Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@H]2OC(=O)C[C@H](O)C2)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 OUCSEDFVYPBLLF-KAYWLYCHSA-N 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- 150000002009 diols Chemical class 0.000 abstract 3
- 159000000000 sodium salts Chemical class 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000005594 diketone group Chemical group 0.000 abstract 1
- 238000004821 distillation Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IE2005/000094 WO2007029216A1 (en) | 2005-09-09 | 2005-09-09 | Preparation of an atorvastatin intermediate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE432276T1 true ATE432276T1 (de) | 2009-06-15 |
Family
ID=36283782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05777481T ATE432276T1 (de) | 2005-09-09 | 2005-09-09 | Herstellung eines atorvastatin-zwischenprodukts |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20090221839A1 (de) |
| EP (1) | EP1922315B1 (de) |
| JP (1) | JP2009507821A (de) |
| AT (1) | ATE432276T1 (de) |
| CA (1) | CA2621506A1 (de) |
| DE (1) | DE602005014686D1 (de) |
| WO (1) | WO2007029216A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2451159A1 (en) | 2001-07-06 | 2003-01-16 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives |
| WO2009023260A2 (en) * | 2007-08-15 | 2009-02-19 | Teva Pharmaceutical Industries Ltd. | An improved process for synthesis of pyrrole derivative, an intermediate for atorvastatin |
| KR100850558B1 (ko) | 2008-01-02 | 2008-08-06 | 조동옥 | 아토르바스타틴의 효율적인 제조방법 |
| KR100850850B1 (ko) | 2008-01-25 | 2008-08-06 | 주식회사종근당 | 아토르바스타틴의 제조방법 및 이에 사용되는 중간체 |
| JP5705580B2 (ja) * | 2011-02-21 | 2015-04-22 | 公益財団法人微生物化学研究会 | チオアミド化合物、チオアミド化合物の製造方法、［（４ｒ，６ｒ）−６−アミノエチル−１，３−ジオキサン−４−イル］アセテート誘導体の製造方法、及びアトルバスタチンの製造方法 |
| CN111362856B (zh) * | 2020-04-29 | 2023-08-18 | 福建海西新药创制股份有限公司 | 一种利用微反应装置生产阿托伐他汀钙的方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4681893A (en) * | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
| US5245047A (en) * | 1988-02-22 | 1993-09-14 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| US5216174A (en) * | 1988-02-22 | 1993-06-01 | Warner-Lambert Co. | Process for trans-6-[12-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| US5003080A (en) * | 1988-02-22 | 1991-03-26 | Warner-Lambert Company | Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis |
| US5124482A (en) * | 1988-02-22 | 1992-06-23 | Warner-Lambert Company | Process for trans-6-(2-substituted-pyrrol-1-yl)alkyl)pyran-2-one inhibitors of cholesterol synthesis |
| US5097045A (en) * | 1989-02-01 | 1992-03-17 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| US5149837A (en) * | 1988-02-22 | 1992-09-22 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| FI94339C (fi) * | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| US5248793A (en) * | 1990-10-17 | 1993-09-28 | Warner-Lambert Company | Process for the synthesis of (4R-cis)-1,1-dimethylethyl 6-iodomethyl or 6-(phenyl-substituted)sulfonyloxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate |
| US5103024A (en) * | 1990-10-17 | 1992-04-07 | Warner-Lambert Company | Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate |
| US5155251A (en) * | 1991-10-11 | 1992-10-13 | Warner-Lambert Company | Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate |
| US5298627A (en) * | 1993-03-03 | 1994-03-29 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| US6087511A (en) * | 1996-07-16 | 2000-07-11 | Warner-Lambert Company | Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid) calcium salt (2:1) |
| DE19635598A1 (de) * | 1996-09-02 | 1998-03-05 | Focke & Co | Anlage zum Handhaben von insbesondere Zigaretten |
| EP1054860B1 (de) * | 1997-12-19 | 2007-04-25 | Pfizer Ireland Pharmaceuticals | Verfahren zur herstellung von 1,3-diolen |
| HUP0303555A3 (en) * | 2000-11-16 | 2005-08-29 | Teva Pharma | Hydrolysis of [r(r |
-
2005
- 2005-09-09 AT AT05777481T patent/ATE432276T1/de not_active IP Right Cessation
- 2005-09-09 JP JP2008529773A patent/JP2009507821A/ja active Pending
- 2005-09-09 US US12/065,555 patent/US20090221839A1/en not_active Abandoned
- 2005-09-09 EP EP05777481A patent/EP1922315B1/de not_active Expired - Lifetime
- 2005-09-09 DE DE602005014686T patent/DE602005014686D1/de not_active Expired - Fee Related
- 2005-09-09 CA CA002621506A patent/CA2621506A1/en not_active Abandoned
- 2005-09-09 WO PCT/IE2005/000094 patent/WO2007029216A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA2621506A1 (en) | 2007-03-15 |
| DE602005014686D1 (de) | 2009-07-09 |
| US20090221839A1 (en) | 2009-09-03 |
| EP1922315B1 (de) | 2009-05-27 |
| WO2007029216A1 (en) | 2007-03-15 |
| JP2009507821A (ja) | 2009-02-26 |
| EP1922315A1 (de) | 2008-05-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |