ATE432276T1 - Herstellung eines atorvastatin-zwischenprodukts - Google Patents

Herstellung eines atorvastatin-zwischenprodukts

Info

Publication number
ATE432276T1
ATE432276T1 AT05777481T AT05777481T ATE432276T1 AT E432276 T1 ATE432276 T1 AT E432276T1 AT 05777481 T AT05777481 T AT 05777481T AT 05777481 T AT05777481 T AT 05777481T AT E432276 T1 ATE432276 T1 AT E432276T1
Authority
AT
Austria
Prior art keywords
diol
ester
atorvastatin
acid
acetonide
Prior art date
Application number
AT05777481T
Other languages
English (en)
Inventor
Susan O'sullivan
John O'neill
Original Assignee
Pfizer Science & Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Science & Tech Ltd filed Critical Pfizer Science & Tech Ltd
Application granted granted Critical
Publication of ATE432276T1 publication Critical patent/ATE432276T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
AT05777481T 2005-09-09 2005-09-09 Herstellung eines atorvastatin-zwischenprodukts ATE432276T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IE2005/000094 WO2007029216A1 (en) 2005-09-09 2005-09-09 Preparation of an atorvastatin intermediate

Publications (1)

Publication Number Publication Date
ATE432276T1 true ATE432276T1 (de) 2009-06-15

Family

ID=36283782

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05777481T ATE432276T1 (de) 2005-09-09 2005-09-09 Herstellung eines atorvastatin-zwischenprodukts

Country Status (7)

Country Link
US (1) US20090221839A1 (de)
EP (1) EP1922315B1 (de)
JP (1) JP2009507821A (de)
AT (1) ATE432276T1 (de)
CA (1) CA2621506A1 (de)
DE (1) DE602005014686D1 (de)
WO (1) WO2007029216A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7199261B2 (en) 2001-07-06 2007-04-03 Teva Pharmaceutical Industries Ltd Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives
US20090081801A1 (en) * 2007-08-15 2009-03-26 Vinod Kumar Kansal Process for synthesis of pyrrole derivative, an intermediate for atorvastatin
KR100850558B1 (ko) 2008-01-02 2008-08-06 조동옥 아토르바스타틴의 효율적인 제조방법
KR100850850B1 (ko) 2008-01-25 2008-08-06 주식회사종근당 아토르바스타틴의 제조방법 및 이에 사용되는 중간체
JP5705580B2 (ja) * 2011-02-21 2015-04-22 公益財団法人微生物化学研究会 チオアミド化合物、チオアミド化合物の製造方法、［（４ｒ，６ｒ）−６−アミノエチル−１，３−ジオキサン−４−イル］アセテート誘導体の製造方法、及びアトルバスタチンの製造方法
CN111362856B (zh) * 2020-04-29 2023-08-18 福建海西新药创制股份有限公司 一种利用微反应装置生产阿托伐他汀钙的方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US5216174A (en) * 1988-02-22 1993-06-01 Warner-Lambert Co. Process for trans-6-[12-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5149837A (en) * 1988-02-22 1992-09-22 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5124482A (en) * 1988-02-22 1992-06-23 Warner-Lambert Company Process for trans-6-(2-substituted-pyrrol-1-yl)alkyl)pyran-2-one inhibitors of cholesterol synthesis
US5003080A (en) * 1988-02-22 1991-03-26 Warner-Lambert Company Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis
US5097045A (en) * 1989-02-01 1992-03-17 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5245047A (en) * 1988-02-22 1993-09-14 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
FI94339C (fi) * 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US5103024A (en) * 1990-10-17 1992-04-07 Warner-Lambert Company Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5248793A (en) * 1990-10-17 1993-09-28 Warner-Lambert Company Process for the synthesis of (4R-cis)-1,1-dimethylethyl 6-iodomethyl or 6-(phenyl-substituted)sulfonyloxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5155251A (en) * 1991-10-11 1992-10-13 Warner-Lambert Company Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
US5298627A (en) * 1993-03-03 1994-03-29 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US6087511A (en) * 1996-07-16 2000-07-11 Warner-Lambert Company Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid) calcium salt (2:1)
DE19635598A1 (de) * 1996-09-02 1998-03-05 Focke & Co Anlage zum Handhaben von insbesondere Zigaretten
KR100668575B1 (ko) * 1997-12-19 2007-01-17 워너-램버트 익스포트 리미티드 1,3-디올의 합성방법
US6528661B2 (en) * 2000-11-16 2003-03-04 Teva Pharmaceutical Industries Ltd. Hydrolysis of [R(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino) carbonyl]-1H-pyrrole-1-heptanoic acid esters with calcium hydroxide

Also Published As

Publication number Publication date
CA2621506A1 (en) 2007-03-15
JP2009507821A (ja) 2009-02-26
WO2007029216A1 (en) 2007-03-15
EP1922315B1 (de) 2009-05-27
DE602005014686D1 (de) 2009-07-09
EP1922315A1 (de) 2008-05-21
US20090221839A1 (en) 2009-09-03

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