DK1727795T3 - Fremgangsmåde til fremstillingen af atorvastatin-calcium i amorf form - Google Patents

Fremgangsmåde til fremstillingen af atorvastatin-calcium i amorf form

Info

Publication number
DK1727795T3
DK1727795T3 DK04798913.2T DK04798913T DK1727795T3 DK 1727795 T3 DK1727795 T3 DK 1727795T3 DK 04798913 T DK04798913 T DK 04798913T DK 1727795 T3 DK1727795 T3 DK 1727795T3
Authority
DK
Denmark
Prior art keywords
amorf
procedure
preparation
atorvastatin calcium
atorvastatin
Prior art date
Application number
DK04798913.2T
Other languages
English (en)
Inventor
Yatendra Kumar
S M Kumar
Swargam Sathyanarayana
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Application granted granted Critical
Publication of DK1727795T3 publication Critical patent/DK1727795T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
DK04798913.2T 2004-03-17 2004-11-19 Fremgangsmåde til fremstillingen af atorvastatin-calcium i amorf form DK1727795T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN491DE2004 2004-03-17
PCT/IB2004/003789 WO2005092852A1 (en) 2004-03-17 2004-11-19 Process for the production of atorvastatin calcium in amorphous form

Publications (1)

Publication Number Publication Date
DK1727795T3 true DK1727795T3 (da) 2012-04-16

Family

ID=33516010

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04798913.2T DK1727795T3 (da) 2004-03-17 2004-11-19 Fremgangsmåde til fremstillingen af atorvastatin-calcium i amorf form

Country Status (17)

Country Link
US (1) US7994343B2 (da)
EP (3) EP1727795B1 (da)
CN (2) CN1942439B (da)
AR (1) AR048271A1 (da)
AT (1) ATE545629T1 (da)
AU (2) AU2004317570B2 (da)
CA (3) CA2560252C (da)
CY (1) CY1112583T1 (da)
DK (1) DK1727795T3 (da)
ES (1) ES2381473T3 (da)
FI (1) FI120344B (da)
MY (1) MY147435A (da)
NO (1) NO330092B1 (da)
PL (1) PL1727795T3 (da)
PT (1) PT1727795E (da)
SI (1) SI1727795T1 (da)
WO (1) WO2005092852A1 (da)

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CN102070504A (zh) * 2010-12-23 2011-05-25 蚌埠丰原医药科技发展有限公司 阿托伐他汀钠的制备方法
CN102070505B (zh) * 2011-01-28 2012-01-11 海南美大制药有限公司 阿托伐他汀钙化合物及其新制法
CN103483238B (zh) * 2013-08-20 2014-12-31 蚌埠丰原医药科技发展有限公司 阿托伐他汀钙三水合物的制备方法
CN104945300B (zh) * 2015-06-17 2017-05-10 北京嘉林药业股份有限公司 一种ⅰ型阿托伐他汀钙的纯化方法
WO2017060885A1 (en) * 2015-10-09 2017-04-13 Laurus Labs Private Limited An improved process for preparation of atorvastatin or pharmaceutically acceptable salts thereof
CN106478591B (zh) * 2016-09-30 2018-11-13 北京嘉林药业股份有限公司 一种阿托伐他汀缩合物中间体的拆分方法
CN106432033B (zh) * 2016-10-21 2018-07-27 江苏阿尔法药业有限公司 一种无定形阿托伐他汀钙的制备方法
CN108033899B (zh) * 2017-12-06 2020-04-10 浙江科技学院 一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法
CN109280024A (zh) * 2018-10-09 2019-01-29 河南师范大学 一种高纯度阿托伐他汀叔丁酯的制备方法
CN109232355A (zh) * 2018-10-09 2019-01-18 河南师范大学 一种有效去除阿托伐他汀钙粗品中杂质阿托伐他汀缩合物的方法
CN110563628B (zh) * 2019-08-26 2022-04-05 北京嘉林药业股份有限公司 一种双釜制备高纯度和单分散i晶型阿托伐他汀钙的结晶方法
CN110776451B (zh) * 2020-01-02 2020-05-22 湖南迪诺制药股份有限公司 一种i晶型阿托伐他汀钙的制备方法
CN113695307B (zh) * 2020-05-20 2022-12-02 天津嘉林科医有限公司 一种盛放阿托伐他汀钙的玻璃器皿的清洗方法

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Also Published As

Publication number Publication date
CN1942439B (zh) 2011-12-21
NO20045037L (no) 2005-09-19
CA2560252A1 (en) 2005-10-06
EP1727795A1 (en) 2006-12-06
WO2005092852A1 (en) 2005-10-06
CA2666359A1 (en) 2005-10-06
PT1727795E (pt) 2012-04-11
AU2010249166A1 (en) 2010-12-23
ATE545629T1 (de) 2012-03-15
AU2004317570B2 (en) 2011-01-06
MY147435A (en) 2012-12-14
EP1659110A1 (en) 2006-05-24
US7994343B2 (en) 2011-08-09
PL1727795T3 (pl) 2012-06-29
FI20041489A0 (fi) 2004-11-19
NO20045037D0 (no) 2004-11-19
SI1727795T1 (sl) 2012-05-31
AU2010249166B2 (en) 2012-02-09
CA2627940A1 (en) 2005-10-06
AR048271A1 (es) 2006-04-12
CY1112583T1 (el) 2016-02-10
ES2381473T3 (es) 2012-05-28
EP1727795B1 (en) 2012-02-15
NO330092B1 (no) 2011-02-14
CA2560252C (en) 2009-08-04
US20100197941A1 (en) 2010-08-05
AU2004317570A1 (en) 2005-10-06
EP1577297A1 (en) 2005-09-21
CN1942439A (zh) 2007-04-04
CN1946688A (zh) 2007-04-11
FI20041489A (fi) 2006-07-20
FI120344B (fi) 2009-09-30

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