AR048271A1 - Procesos para la produccion de calcio de atorvastatina en forma amorfa - Google Patents

Procesos para la produccion de calcio de atorvastatina en forma amorfa

Info

Publication number
AR048271A1
AR048271A1 ARP050101018A ARP050101018A AR048271A1 AR 048271 A1 AR048271 A1 AR 048271A1 AR P050101018 A ARP050101018 A AR P050101018A AR P050101018 A ARP050101018 A AR P050101018A AR 048271 A1 AR048271 A1 AR 048271A1
Authority
AR
Argentina
Prior art keywords
atorvastatin calcium
calcium
atorvastatin
amorphous form
alkali metal
Prior art date
Application number
ARP050101018A
Other languages
English (en)
Inventor
Yatendra Kumar
Madhava Dileep Kumar Saridi
Swargam Sathyanarayana
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Publication of AR048271A1 publication Critical patent/AR048271A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reivindicacion 1: Un proceso para la produccion de calcio de atorvastatina en forma amorfa que comprende: a) reaccionar una solucion de (4R-cis)-1,1-dimetiletil-6-{2-[2-(4-fluorofenil)-5-(1-metiletil)-3-fenil-4-[(fenilamino)-carbonil]-1H-pirrol- 1il]etil}-2,2-dimetil-1,3-dioxano-4-acetato (Compuesto H) en un solvente miscible en agua con un ácido para obtener [R-(R*,R*)]-1,1-dimetiletil-2-(4-fluorofenil)-beta, delta-dihidroxi-5-(1-metiletil)-3-fenil-4-[(fenilamino) carbonil]-1H-pirrole-1- heptanoato (Compuesto I); b) tratar el Compuesto I con un hidroxido metálico álcali para obtener una sal metálica álcali de atorvastatina; c) lavar la solucion de sal metálica álcali de astorvastatina con un solvente no miscible o levemente miscible en agua; d) tratar la solucion lavada de sal metálica álcali de atorvastatina con una sal de calcio o hidroxido de calcio para obtener calcio de atorvastatina; e) aislar el calcio de atorvastatina crudo; f) purificar el calcio de atorvastatina crudo mediante la disolucion en una mezcla de tetrahidrofurano y metanol, y precipitando con agua para obtener calcio de atorvastatina puro en forma cristalina; y g) convertir el calcio de atorvastatina cristalino puro así obtenido en forma amorfa. Reivindicacion 29: UN proceso para la produccion de calcio de atorvastatina estabilizado, en forma amorfa que comprende: a) La disolucion del calcio de atorvastatina cristalino y un antioxidante en un solvente; b) El agregado de calcio de atorvastatina y solucion antioxidante a un antisolvente y c) La separacion del calcio de atorvastatina precipitado, en forma amorfa de la suspension resultante para obtener calcio de atorvastatina estabilizado, en forma amorfa.
ARP050101018A 2004-03-17 2005-03-16 Procesos para la produccion de calcio de atorvastatina en forma amorfa AR048271A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN491DE2004 2004-03-17

Publications (1)

Publication Number Publication Date
AR048271A1 true AR048271A1 (es) 2006-04-12

Family

ID=33516010

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050101018A AR048271A1 (es) 2004-03-17 2005-03-16 Procesos para la produccion de calcio de atorvastatina en forma amorfa

Country Status (17)

Country Link
US (1) US7994343B2 (es)
EP (3) EP1577297A1 (es)
CN (2) CN1942439B (es)
AR (1) AR048271A1 (es)
AT (1) ATE545629T1 (es)
AU (2) AU2004317570B2 (es)
CA (3) CA2560252C (es)
CY (1) CY1112583T1 (es)
DK (1) DK1727795T3 (es)
ES (1) ES2381473T3 (es)
FI (1) FI120344B (es)
MY (1) MY147435A (es)
NO (1) NO330092B1 (es)
PL (1) PL1727795T3 (es)
PT (1) PT1727795E (es)
SI (1) SI1727795T1 (es)
WO (1) WO2005092852A1 (es)

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CN101468963B (zh) * 2007-12-28 2012-09-19 石药集团中奇制药技术（石家庄）有限公司 一种无定形阿伐他汀钙的制备方法
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CN102127060B (zh) * 2010-12-17 2013-12-04 蚌埠丰原医药科技发展有限公司 一种阿托伐他汀钙中间体的制备方法
CN102070504A (zh) * 2010-12-23 2011-05-25 蚌埠丰原医药科技发展有限公司 阿托伐他汀钠的制备方法
CN102070505B (zh) * 2011-01-28 2012-01-11 海南美大制药有限公司 阿托伐他汀钙化合物及其新制法
CN103483238B (zh) * 2013-08-20 2014-12-31 蚌埠丰原医药科技发展有限公司 阿托伐他汀钙三水合物的制备方法
CN104945300B (zh) * 2015-06-17 2017-05-10 北京嘉林药业股份有限公司 一种ⅰ型阿托伐他汀钙的纯化方法
WO2017060885A1 (en) * 2015-10-09 2017-04-13 Laurus Labs Private Limited An improved process for preparation of atorvastatin or pharmaceutically acceptable salts thereof
CN106478591B (zh) * 2016-09-30 2018-11-13 北京嘉林药业股份有限公司 一种阿托伐他汀缩合物中间体的拆分方法
CN106432033B (zh) * 2016-10-21 2018-07-27 江苏阿尔法药业有限公司 一种无定形阿托伐他汀钙的制备方法
CN108033899B (zh) * 2017-12-06 2020-04-10 浙江科技学院 一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法
CN109232355A (zh) * 2018-10-09 2019-01-18 河南师范大学 一种有效去除阿托伐他汀钙粗品中杂质阿托伐他汀缩合物的方法
CN109280024A (zh) * 2018-10-09 2019-01-29 河南师范大学 一种高纯度阿托伐他汀叔丁酯的制备方法
CN110563628B (zh) * 2019-08-26 2022-04-05 北京嘉林药业股份有限公司 一种双釜制备高纯度和单分散i晶型阿托伐他汀钙的结晶方法
CN110776451B (zh) * 2020-01-02 2020-05-22 湖南迪诺制药股份有限公司 一种i晶型阿托伐他汀钙的制备方法
CN113695307B (zh) * 2020-05-20 2022-12-02 天津嘉林科医有限公司 一种盛放阿托伐他汀钙的玻璃器皿的清洗方法

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Also Published As

Publication number Publication date
PT1727795E (pt) 2012-04-11
CN1946688A (zh) 2007-04-11
EP1577297A1 (en) 2005-09-21
FI20041489A (fi) 2006-07-20
CN1942439B (zh) 2011-12-21
CA2560252C (en) 2009-08-04
CA2560252A1 (en) 2005-10-06
EP1659110A1 (en) 2006-05-24
US20100197941A1 (en) 2010-08-05
WO2005092852A1 (en) 2005-10-06
US7994343B2 (en) 2011-08-09
AU2010249166B2 (en) 2012-02-09
FI20041489A0 (fi) 2004-11-19
ATE545629T1 (de) 2012-03-15
CN1942439A (zh) 2007-04-04
NO20045037L (no) 2005-09-19
SI1727795T1 (sl) 2012-05-31
MY147435A (en) 2012-12-14
EP1727795B1 (en) 2012-02-15
AU2004317570A1 (en) 2005-10-06
EP1727795A1 (en) 2006-12-06
FI120344B (fi) 2009-09-30
ES2381473T3 (es) 2012-05-28
AU2010249166A1 (en) 2010-12-23
NO20045037D0 (no) 2004-11-19
AU2004317570B2 (en) 2011-01-06
CY1112583T1 (el) 2016-02-10
CA2627940A1 (en) 2005-10-06
NO330092B1 (no) 2011-02-14
DK1727795T3 (da) 2012-04-16
CA2666359A1 (en) 2005-10-06
PL1727795T3 (pl) 2012-06-29

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