ATE523484T1 - Optische lösung a us 3-carbamoylmethyl-5-methyl- hexansäure - Google Patents
Optische lösung a us 3-carbamoylmethyl-5-methyl- hexansäureInfo
- Publication number
- ATE523484T1 ATE523484T1 AT06759590T AT06759590T ATE523484T1 AT E523484 T1 ATE523484 T1 AT E523484T1 AT 06759590 T AT06759590 T AT 06759590T AT 06759590 T AT06759590 T AT 06759590T AT E523484 T1 ATE523484 T1 AT E523484T1
- Authority
- AT
- Austria
- Prior art keywords
- carbamoylmethyl
- methyl
- optical solution
- cmh
- hexanic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/16—Preparation of optical isomers
- C07C231/20—Preparation of optical isomers by separation of optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67978405P | 2005-05-10 | 2005-05-10 | |
US68969905P | 2005-06-09 | 2005-06-09 | |
US73300905P | 2005-11-02 | 2005-11-02 | |
US73563405P | 2005-11-09 | 2005-11-09 | |
US74095005P | 2005-11-29 | 2005-11-29 | |
PCT/US2006/018273 WO2006122259A1 (en) | 2005-05-10 | 2006-05-10 | Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE523484T1 true ATE523484T1 (de) | 2011-09-15 |
Family
ID=36940669
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06759590T ATE523484T1 (de) | 2005-05-10 | 2006-05-10 | Optische lösung a us 3-carbamoylmethyl-5-methyl- hexansäure |
Country Status (9)
Country | Link |
---|---|
US (4) | US20070043241A1 (de) |
EP (1) | EP1879854B1 (de) |
KR (2) | KR20070118305A (de) |
AT (1) | ATE523484T1 (de) |
CA (1) | CA2604624A1 (de) |
ES (1) | ES2372700T3 (de) |
IL (1) | IL185032A0 (de) |
MX (1) | MX2007014129A (de) |
WO (1) | WO2006122259A1 (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009004643A2 (en) * | 2007-05-08 | 2009-01-08 | Cadila Healthcare Limited | An improved process for preparation of (s)-pregabalin and intermediates thereof |
WO2009125427A2 (en) * | 2008-02-18 | 2009-10-15 | Matrix Laboratories Limited | Process for preparing (s)-3-(aminomethyl)-5-methylhexanoic acid |
UA103997C2 (ru) | 2008-05-21 | 2013-12-25 | Сандоз Аг | Способ стереоселективного ферментативного гидролиза эстера 5-метил-3-нитрометилгексановой кислоты |
WO2016075082A1 (en) | 2014-11-10 | 2016-05-19 | Sandoz Ag | Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam |
CN113801031B (zh) * | 2021-10-26 | 2023-12-26 | 浙江华海药业股份有限公司 | 一种普瑞巴林的纯化方法 |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE86971T1 (de) * | 1986-08-13 | 1993-04-15 | Ciba Geigy Ag | Verfahren zur herstellung von 5-amino-4hydroxyvalerians|ure-derivaten. |
US6197819B1 (en) * | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
US5616793A (en) * | 1995-06-02 | 1997-04-01 | Warner-Lambert Company | Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid |
US5637767A (en) * | 1995-06-07 | 1997-06-10 | Warner-Lambert Company | Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid |
DE19530637A1 (de) * | 1995-08-21 | 1997-02-27 | Bayer Ag | Verfahren zur Herstellung von 2,2-Difluorbenzo[1.3]dioxolcarbaldehyden |
CN1094757C (zh) * | 1996-07-24 | 2002-11-27 | 沃尼尔·朗伯公司 | 用于治疗疼痛的异丁基γ-氨基丁酸及其衍生物 |
ES2130079B1 (es) * | 1997-07-10 | 2000-01-16 | Esteve Labor Dr | Resolucion de aminas |
GB9812413D0 (en) * | 1998-06-10 | 1998-08-05 | Glaxo Group Ltd | Compound and its use |
FR2781793B1 (fr) * | 1998-08-03 | 2001-07-20 | Prographarm Lab | Procede de fabrication de granules de gabapentine enrobes |
US6642398B2 (en) * | 1999-06-10 | 2003-11-04 | Warner-Lambert Company | Mono-and disubstituted 3-propyl gamma-aminobutyric acids |
AU777046B2 (en) * | 2000-01-27 | 2004-09-30 | Warner-Lambert Company Llc | Asymmetric synthesis of pregabalin |
EP1268368A2 (de) * | 2000-04-04 | 2003-01-02 | Brandeis University | Katalytische asymmetrische desymmetrisierung von mesoverbindungen |
US6833458B2 (en) * | 2000-06-05 | 2004-12-21 | Development Center For Biotechnology | Practical syntheses of chiral trans-3, 4-disubstituted piperidines and the intermediates |
AU2002333374B2 (en) * | 2001-09-03 | 2007-03-22 | Newron Pharmaceuticals S.P.A. | Pharmaceutical composition comprising gabapentin or an analogue thereof and an (alpha)- aminoamide and its analgesic use |
DE10203122A1 (de) * | 2002-01-25 | 2003-07-31 | Gruenenthal Gmbh | Verfahren zur Herstellung von substituierten Acrylsäureestern bzw. deren Einsatz zur Herstellung von substituierten gamma-Aminosäuren |
US20030225149A1 (en) * | 2002-04-30 | 2003-12-04 | Blazecka Peter G. | Process for preparing highly functionalized gamma-butyrolactams and gamma-amino acids |
US6942377B1 (en) * | 2003-02-19 | 2005-09-13 | Robert B Goldstein | Thermoreactive beverage stirrer |
RU2335342C2 (ru) * | 2004-03-12 | 2008-10-10 | Уорнер-Ламберт Компани Ллс | C1-симметричные бисфосфиновые лиганды и их применение в асимметрическом синтезе прегабалина |
ATE405572T1 (de) * | 2004-04-01 | 2008-09-15 | Warner Lambert Co | Herstellung von p-chirogenen phospholanen und deren verwendung in der asymmetrischen synthese |
UA82292C2 (uk) | 2004-04-14 | 2008-03-25 | Пфайзер Продактс Инк. | Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти) |
ME01067B (me) * | 2004-06-21 | 2012-10-20 | Warner Lambert Co | Dobijanje pregabalina i srodnih jedinjenja |
WO2006008640A1 (en) | 2004-07-15 | 2006-01-26 | Pharmacia & Upjohn Company Llc | Non-aqueous suspension containing a drug having an unpleasant taste |
CN1634869A (zh) | 2004-12-06 | 2005-07-06 | 北京阜康仁生物制药科技有限公司 | 普瑞巴林新晶型及其制备方法 |
CN101300224A (zh) | 2005-04-11 | 2008-11-05 | 特瓦制药工业有限公司 | 制备(s)-普瑞巴林的方法 |
WO2006122258A1 (en) | 2005-05-10 | 2006-11-16 | Teva Pharmaceutical Industries Ltd. | Method for the preparation of pregabalin and salts thereof |
BRPI0605833A (pt) | 2005-05-10 | 2007-12-18 | Teva Pharma | pregabalina livre de ácido isobutilglutárico e um processo para sua preparação |
EP1879852A1 (de) | 2005-05-10 | 2008-01-23 | Teva Pharmaceutical Industries Ltd | Lactamfreies pregabalin und herstellungsverfahren dafür |
US20060270871A1 (en) * | 2005-05-30 | 2006-11-30 | Khanduri Chandra H | Polymorphic form i of pregabalin and processes for its preparation |
CN100410242C (zh) | 2005-06-23 | 2008-08-13 | 江苏恩华药业股份有限公司 | 普瑞巴林中间体及其制备方法 |
CZ297970B6 (cs) | 2005-08-10 | 2007-05-09 | Zentiva, A. S | Zpusob výroby (S)-3-(aminomethyl)-5-methyl-hexanové kyseliny (pregabalinu) |
WO2007035789A1 (en) | 2005-09-19 | 2007-03-29 | Teva Pharmaceutical Industries Ltd. | Chiral 3-carbamoylmethyl-5-methyl hexanoic acids, key intermediates for the new synthesis of (s)-pregabalin |
ITMI20061297A1 (it) | 2006-07-04 | 2008-01-05 | Laboratorio Chimico Int Spa | Procedimento per la preparazione della'acido (r)-(-)-3-(carbamoilmetil)-5-metilesanoico e del pregabalin e intermedi di sintesi |
AU2007274034B2 (en) | 2006-07-12 | 2012-11-15 | Generics [Uk] Limited | Process of preparing a gamma-amino acid |
GB0614133D0 (en) | 2006-07-15 | 2006-08-23 | Pliva Istrazivanje I Razvoj D | Process for preparing a pharmaceutical compound |
US20080014280A1 (en) * | 2006-07-17 | 2008-01-17 | Glenmark Pharmaceuticals Limited | Amorphous pregabalin and process for the preparation thereof |
WO2008062460A2 (en) | 2006-10-06 | 2008-05-29 | Cadila Healthcare Limited | Crystalline forms of pregabalin |
GB0619888D0 (en) | 2006-10-07 | 2006-11-15 | Pliva Istrazivanje I Razvoj D | New polymorphic forms of pregabalin |
EP1992609A1 (de) * | 2007-05-14 | 2008-11-19 | Dipharma Francis S.r.l. | Verfahren für die Herstellung einer (S)(+)-3-(Aminomethyl)-5-Methylhexan-Säure |
EP2017273A1 (de) | 2007-07-18 | 2009-01-21 | Laboratorios del Dr. Esteve S.A. | Verfahren zur enantioselektiven Herstellung von Pregabalin |
ITMI20072262A1 (it) | 2007-12-03 | 2009-06-04 | Dipharma Francis Srl | Procedimento per la preparazione di acido (s)(+)-3-(amminometil)-5-metilesanoico |
-
2006
- 2006-05-10 AT AT06759590T patent/ATE523484T1/de not_active IP Right Cessation
- 2006-05-10 MX MX2007014129A patent/MX2007014129A/es not_active Application Discontinuation
- 2006-05-10 ES ES06759590T patent/ES2372700T3/es active Active
- 2006-05-10 EP EP06759590A patent/EP1879854B1/de not_active Not-in-force
- 2006-05-10 WO PCT/US2006/018273 patent/WO2006122259A1/en active Application Filing
- 2006-05-10 CA CA002604624A patent/CA2604624A1/en not_active Abandoned
- 2006-05-10 US US11/432,010 patent/US20070043241A1/en not_active Abandoned
- 2006-05-10 KR KR1020077025955A patent/KR20070118305A/ko not_active Application Discontinuation
- 2006-05-10 KR KR1020097001670A patent/KR20090019016A/ko not_active Application Discontinuation
-
2007
- 2007-08-02 IL IL185032A patent/IL185032A0/en unknown
- 2007-08-14 US US11/893,300 patent/US20070287860A1/en not_active Abandoned
- 2007-08-14 US US11/893,235 patent/US7678938B2/en not_active Expired - Fee Related
- 2007-08-14 US US11/893,216 patent/US7619112B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1879854B1 (de) | 2011-09-07 |
WO2006122259A1 (en) | 2006-11-16 |
US7619112B2 (en) | 2009-11-17 |
IL185032A0 (en) | 2007-12-03 |
US20070043241A1 (en) | 2007-02-22 |
ES2372700T3 (es) | 2012-01-25 |
KR20090019016A (ko) | 2009-02-24 |
MX2007014129A (es) | 2008-01-11 |
US7678938B2 (en) | 2010-03-16 |
EP1879854A1 (de) | 2008-01-23 |
KR20070118305A (ko) | 2007-12-14 |
US20070287748A1 (en) | 2007-12-13 |
US20070287860A1 (en) | 2007-12-13 |
CA2604624A1 (en) | 2006-11-16 |
US20070287859A1 (en) | 2007-12-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA200870262A1 (ru) | Способ получения оптических активных хиральных аминов | |
BRPI0921408A2 (pt) | processo para a fabricação de (r)-2-acetamido-n-benzil-3-metoxipropion-amida (i) opticamente pura. | |
EA200702346A1 (ru) | КРИСТАЛЛИЧЕСКАЯ ФОРМА 1-ХЛОР-4-(β-D-ГЛЮКОПИРАНОЗ-1-ИЛ)-2-[4-((S)-ТЕТРАГИДРОФУРАН-3-ИЛОКСИ)БЕНЗИЛ]БЕНЗОЛА, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ЕЁ ПРИМЕНЕНИЕ ДЛЯ ПРИГОТОВЛЕНИЯ ЛЕКАРСТВЕННЫХ СРЕДСТВ | |
BRPI0413973A (pt) | compostos | |
DK2057136T3 (da) | Fremgangsmåde til syntese og/eller oprensning af diaminophenothiazinium forbindelser | |
CL2009002201A1 (es) | Procedimiento de sintesis de ivabradina por aminacion reductiva y posterior resolucion optica; y uno de los compuestos intermediarios considerados. | |
WO2007011951A3 (en) | Purification of paricalcitol | |
ATE402753T1 (de) | Reinigung von ionischen flüssigkeiten | |
AR060091A1 (es) | Procedimiento para preparar lentes oftalmicas | |
DK2082054T3 (da) | Fremgangsmåde til forbedring af udbyttet af celluloseomdannelsesprocesser | |
ATE523484T1 (de) | Optische lösung a us 3-carbamoylmethyl-5-methyl- hexansäure | |
UA94449C2 (ru) | Способ получения оптически активного соединения оксида хромена | |
HK1138290A1 (en) | Method of purification of hydrophobic proteins | |
DE602005022099D1 (de) | Fluorisierungsverfahren zur synthese von 2-ä18fü fluoro-2-deoxy-d-glukose | |
EA200801297A1 (ru) | Способ снижения уровня постпрандиальной глюкозы | |
NO20085359L (no) | Fremgangsmate for fremstilling av renset hydrokinon | |
WO2008055110A3 (en) | Photonic crystal euv photoresists | |
DK1838670T3 (da) | Fremgangsmåde til fremstilling af carvedilol og dets enantiomere | |
DK1907396T3 (da) | Fremgangsmåde til fremstilling af 4-beta-amino-4'-demethyl-4-deoxypodophyllotoxin | |
ATE442371T1 (de) | Víllig lísungsmittelfreie cefotetan säure und verfahren zu ihrer herstellung. | |
GT200400195A (es) | Nuevo proceso para reducir el nivel de impurezas en una muestra de mesotriona | |
WO2010058409A3 (en) | Optical purification of esomeprazole | |
ATE550326T1 (de) | Als modulatoren von hdl einsetzbare verbindungen | |
DE602006003204D1 (de) | Reinigungsverfahren von Moxonidine | |
DK1885707T3 (da) | Fremgangsmåde til oprensning af 10-deacetylbaccatin III fra 10-deacetyl-2-debenzoyl-2-pentenoylbaccatin III |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |