DK2057136T3 - Fremgangsmåde til syntese og/eller oprensning af diaminophenothiazinium forbindelser - Google Patents

Fremgangsmåde til syntese og/eller oprensning af diaminophenothiazinium forbindelser

Info

Publication number
DK2057136T3
DK2057136T3 DK07733509.9T DK07733509T DK2057136T3 DK 2057136 T3 DK2057136 T3 DK 2057136T3 DK 07733509 T DK07733509 T DK 07733509T DK 2057136 T3 DK2057136 T3 DK 2057136T3
Authority
DK
Denmark
Prior art keywords
purification
synthesis
diaminophenothiazinium compounds
diaminophenothiazinium
compounds
Prior art date
Application number
DK07733509.9T
Other languages
English (en)
Inventor
Claude Michel Wischik
John Mervyn David Storey
Colin Marshall
James Peter Sinclair
Thomas Craven Baddeley
Original Assignee
Wista Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38669650&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2057136(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wista Lab Ltd filed Critical Wista Lab Ltd
Application granted granted Critical
Publication of DK2057136T3 publication Critical patent/DK2057136T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B21/00—Thiazine dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
    • C09B67/0096—Purification; Precipitation; Filtration
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
    • C09B67/0097—Dye preparations of special physical nature; Tablets, films, extrusion, microcapsules, sheets, pads, bags with dyes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • AIDS & HIV (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK07733509.9T 2006-07-11 2007-07-10 Fremgangsmåde til syntese og/eller oprensning af diaminophenothiazinium forbindelser DK2057136T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81962706P 2006-07-11 2006-07-11
PCT/GB2007/002570 WO2008007074A2 (en) 2006-07-11 2007-07-10 Methods of synthesis and/or purification of diaminophenothiazinium compounds

Publications (1)

Publication Number Publication Date
DK2057136T3 true DK2057136T3 (da) 2013-08-26

Family

ID=38669650

Family Applications (4)

Application Number Title Priority Date Filing Date
DK16173815.8T DK3121169T3 (da) 2006-07-11 2007-07-10 Fremgangsmåder til syntese og/eller oprensning af diaminophenothiaziniumforbindelser
DK11173334.1T DK2457904T3 (da) 2006-07-11 2007-07-10 Fremgangsmåder til syntese og/eller oprensning af diaminophenothiazinium-forbindelser
DK07733509.9T DK2057136T3 (da) 2006-07-11 2007-07-10 Fremgangsmåde til syntese og/eller oprensning af diaminophenothiazinium forbindelser
DK11173338.2T DK2457905T3 (da) 2006-07-11 2007-07-10 Fremgangsmåder til syntese og/eller oprensning af diaminophenothiaziniumforbindelser

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK16173815.8T DK3121169T3 (da) 2006-07-11 2007-07-10 Fremgangsmåder til syntese og/eller oprensning af diaminophenothiaziniumforbindelser
DK11173334.1T DK2457904T3 (da) 2006-07-11 2007-07-10 Fremgangsmåder til syntese og/eller oprensning af diaminophenothiazinium-forbindelser

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK11173338.2T DK2457905T3 (da) 2006-07-11 2007-07-10 Fremgangsmåder til syntese og/eller oprensning af diaminophenothiaziniumforbindelser

Country Status (16)

Country Link
US (10) US7956183B2 (da)
EP (5) EP2457904B1 (da)
JP (2) JP5350237B2 (da)
CN (2) CN101511803B (da)
AU (1) AU2007274057B2 (da)
CA (1) CA2657352C (da)
CY (1) CY1118184T1 (da)
DK (4) DK3121169T3 (da)
ES (4) ES2421930T3 (da)
HU (1) HUE030621T2 (da)
LT (1) LT2457905T (da)
MY (2) MY148145A (da)
PL (4) PL2457905T3 (da)
PT (4) PT3121169T (da)
SI (4) SI3121169T1 (da)
WO (1) WO2008007074A2 (da)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1799662B1 (en) 2004-09-23 2013-04-17 Wista Laboratories Ltd. Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (mtc)
DE602007008550D1 (de) 2006-03-29 2010-09-30 Wista Lab Ltd 3,7-diamino-10h-phenothiazinsalze und ihre verwendung
EP2457904B1 (en) * 2006-07-11 2014-11-19 Wista Laboratories Ltd. Methods of synthesis and/or purification of diaminophenothiazinium compounds
FR2903696B1 (fr) 2006-07-12 2011-02-11 Provence Technologies Procede de purification de composes diaminophenothiazium
WO2008155533A2 (en) * 2007-06-19 2008-12-24 Wista Laboratories Ltd Phenothiazine compounds for treating mild cognitive impairment
US9149481B2 (en) 2007-10-03 2015-10-06 Wista Laboratories Ltd. Therapeutic use of diaminophenothiazines
EP2376470B1 (en) * 2008-12-09 2013-04-10 Interquim, S.A Process for the preparation of (6s)-(-)-5,6,7,8-tetrahydro-6-[propyl-(2-thienyl)ethyl]amino-1-naphthol (rotigotine)
CN102958525B (zh) 2010-04-30 2017-05-24 普罗瑟塔抗病毒股份有限公司 抗病毒化合物
DE102010062810B4 (de) * 2010-09-07 2014-03-13 Immungenetics Ag 2-(R2-Thio)-10-[3-(4-R1-piperazin-1-yl)propyl]-10H-phenothiazine zur Behandlung neurodegenerativer Erkrankungen ausgewählt aus beta-Amyloidopathien und alpha-Synucleinopathien
AU2011358840B2 (en) 2011-02-11 2017-05-04 TauRx Therapeutics Management Ltd Phenothiazine diaminium salts and their use
WO2012145567A1 (en) 2011-04-20 2012-10-26 Prosetta Antiviral Inc. Antiviral compounds
RU2535073C1 (ru) * 2013-07-18 2014-12-10 Федеральное государственное бюджетное учреждение науки "Научно-исследовательский институт общей реаниматологии имени В.А. Неговского" Российской академии медицинских наук Способ лечения метгемоглобинемии
KR101741235B1 (ko) * 2013-08-15 2017-05-29 유파마 피티와이 엘티디 디아미노페노티아지니움 화합물을 정제하는 방법
GB201317702D0 (en) * 2013-10-07 2013-11-20 Wista Lab Ltd Methods of chemical synthesis of diaminophenothiazinium compounds including methylthioninium chloride (MTC)
FR3015481B1 (fr) * 2013-12-20 2016-08-12 Etat Francais Represente Par Le Delegue General Pour L'armement Utilisation de composes de diaminophenothiazinium en tant qu'agents de prevention, reduction ou suppression d'une radiotoxicite
CN103864717B (zh) * 2014-04-04 2015-11-11 山东理工大学 一种针状亚甲基白晶体的制备方法
EP3259254B1 (en) 2015-02-17 2020-07-01 Arizona Board of Regents on behalf of Arizona State University Deuterated and undeuterated 2-amino-pyrimidin-5-ol derivatives for treating mitochondrial diseases (e.g. obesity)
WO2016133995A1 (en) 2015-02-17 2016-08-25 Arizona Board Of Regents On Behalf Of Arizona State University Phenothiazine analogues as mitochondrial therapeutic agents
GB201512678D0 (en) * 2015-07-20 2015-08-26 Wista Lab Ltd Methods of chemical synthesis
CN105399703B (zh) * 2015-12-15 2018-02-13 江苏恒润制药有限公司 一种亚甲基蓝的制备方法
CN105541756B (zh) * 2015-12-17 2018-02-09 陕西方舟制药有限公司 一种制备1‑(3，7‑双二甲氨基‑吩噻嗪‑10‑基)乙酮的方法
ITUA20163526A1 (it) * 2016-05-17 2017-11-17 Icrom Spa Procedimento per la preparazione di composti diamminofenotiazinici ad elevato grado di purezza
HRP20230628T1 (hr) 2016-07-25 2023-09-29 Wista Laboratories Ltd. Primjena i doziranje diaminofenotiazina
US11390605B2 (en) 2016-08-25 2022-07-19 Arizona Board Of Regents On Behalf Of Arizona State University Substituted pyrimidine compounds as multifunctional radical quenchers and their uses
US12570622B2 (en) 2016-08-25 2026-03-10 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds
WO2018039487A1 (en) 2016-08-25 2018-03-01 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds
GB201614834D0 (en) 2016-09-01 2016-10-19 Wista Lab Ltd Treatment of dementia
GB201621817D0 (en) 2016-12-21 2017-02-01 Wista Lab Ltd Methods of chemical synthesis
US11413240B2 (en) 2016-12-29 2022-08-16 Board Of Regents, The University Of Texas System Methylene blue solution for the treatment of oral lesions
WO2018132320A1 (en) * 2017-01-10 2018-07-19 The Texas A&M University System Methanesulfonic acid mediated solvent free synthesis of conjugated porous polymer networks
FR3063495B1 (fr) * 2017-03-02 2019-04-05 Provepharm Life Solutions Procede de preparation de l’iodure de 3,7-bis(dimethylamino)phenothiazine-5-ylium
EP3375777A1 (en) * 2017-03-15 2018-09-19 MIKROCHEM spol. s.r.o. Method for preparation of 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride or bromide
PT3826639T (pt) 2018-07-26 2024-10-09 Wista Lab Ltd Dosagem otimizada de diaminofenotiazinas em populações
US11350853B2 (en) 2018-10-02 2022-06-07 Under Armour, Inc. Gait coaching in fitness tracking systems
CN109337681B (zh) * 2018-11-22 2020-05-08 南京工业大学 一种硫氮共掺杂的碳量子点的制备方法和应用
TR201818670A2 (tr) 2018-12-05 2020-06-22 Eti Gida Sanayi Ve Ticaret Anonim Sirketi Sızıntı yapmayan gıda dolgu maddesi depozitör sistemi.
US12215234B2 (en) * 2019-09-21 2025-02-04 RK Pharma Solutions LLC Process for the purification of methylene blue
CA3169480A1 (en) * 2020-02-28 2021-09-02 Janmejay R. VYAS A process for the preparation of methylene blue
US12280062B2 (en) 2021-02-24 2025-04-22 Zydus Lifesciences Limited Parenteral compositions comprising methylene blue
CN114806211B (zh) * 2022-03-16 2023-04-07 深圳先进技术研究院 一种疏水性亚甲蓝荧光染料及其制备方法和应用
CN114656424B (zh) * 2022-03-16 2023-06-27 深圳先进技术研究院 一种上转换长余辉化学发光成像纳米探针及其制备方法和应用
CN114507193B (zh) * 2022-04-19 2022-06-24 英科隆生物技术（杭州）有限公司 电子媒介体天青c的提纯方法
EP4512802A1 (en) * 2022-04-19 2025-02-26 Leadway (HK) Limited Purification method for electron mediator
CN116947783A (zh) * 2022-04-19 2023-10-27 英科隆生物技术（杭州）有限公司 一种电子媒介体的提纯方法
JP2025518248A (ja) 2022-05-31 2025-06-12 ウィスタ ラボラトリーズ リミテッド メチルチオニニウム（ｍｔ）含有化合物を利用した神経変性障害の処置
CN114989113A (zh) * 2022-06-01 2022-09-02 山东科源制药股份有限公司 一种药用亚甲基蓝的精制方法
CA3268316A1 (en) 2022-09-21 2024-03-28 Wista Laboratories Ltd. NEW FORMULATIONS AND VEHICLES
EP4342451A1 (en) 2022-09-22 2024-03-27 Galenicum Health SLU Pharmaceutical compositions and manufacturing methods thereof
US20240115579A1 (en) 2022-09-22 2024-04-11 Galenicum Health S.L.U. Pharmaceutical compositions and manufacturing methods thereof
CN117447421A (zh) * 2023-10-30 2024-01-26 上海沃凯生物技术有限公司 一种3,7-双-（二甲胺基）-吩噻嗪的合成方法
CN119823064B (zh) * 2025-01-03 2025-12-30 仁合益康集团有限公司 一种亚甲蓝的制备方法

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1886C (de) 1877-12-15 1877-12-15 Basf Ag Verfahren zur darstellung blauer farbstoffe aus dimethylanilin und anderen tertiaeren aromatischen monaminen
DE103147C (de) 1898-06-07 1899-04-05 Cohn Georg Verfahren zur darstellung von acetylleukomethylenblau und -äthylenblau.
DE113721C (de) 1899-06-01 1900-09-28 Verfahren zur Darstellung von Acidylderivaten der Leukothioninfarbstoffe
US3395018A (en) * 1964-04-29 1968-07-30 Du Pont Light-sensitive color-forming composition
US3641016A (en) * 1968-02-16 1972-02-08 Egyt Gyogyszervegyeszeti Gyar Thionine derivatives
DE2515966C3 (de) 1975-04-11 1979-11-22 Boehringer Mannheim Gmbh, 6800 Mannheim Vorgefärbte Objektträger für die Blutunte rsuchung
US4003892A (en) 1975-04-17 1977-01-18 Serva-Entwicklungslabor V. Grothe & Co. Method of separating thionine and its N-methyl derivatives from each other
US4212971A (en) 1979-03-08 1980-07-15 American Cyanamid Company Process for preparing methylene blue
JPS6385644A (ja) * 1986-09-30 1988-04-16 Ricoh Co Ltd 電子写真現像剤用トナ−
US5344928A (en) 1991-04-26 1994-09-06 Takeda Chemical Industries, Ltd. Phenothiazine derivatives, their production and use
US6238931B1 (en) * 1993-09-24 2001-05-29 Biosite Diagnostics, Inc. Fluorescence energy transfer in particles
GB9506197D0 (en) 1995-03-27 1995-05-17 Hoffmann La Roche Inhibition of tau-tau association.
CA2278245A1 (en) 1997-01-21 1998-07-23 The American National Red Cross Intracellular and extracellular decontamination of whole blood and blood components by amphiphilic phenothiazin-5-ium dyes plus light
JP2000344685A (ja) 1999-03-26 2000-12-12 Bf Kenkyusho:Kk アズールａ類似化合物によるアミロイドが蓄積する疾患の画像診断プローブおよびそれを含む画像診断用組成物
IT1307270B1 (it) 1999-10-12 2001-10-30 Dideco Spa Procedimento e dispositivo per la determinazione della concentrazionedi eparina in un campione di fluido.
WO2001062289A2 (en) 2000-02-26 2001-08-30 Advanced Photodynamic Technologies, Inc. Photodynamic cellular and acellular organism eradication utilizing a photosensitive material and surfactant
FR2810318B1 (fr) * 2000-06-15 2005-09-23 Laurent Galey Derives de diamano-phenothiazine
GB0101049D0 (en) 2001-01-15 2001-02-28 Univ Aberdeen Materials and methods relating to protein aggregation in neurodegenerative disease
GB2373787A (en) 2001-03-08 2002-10-02 Univ Central Lancashire Phenothiazinium derivatives and their use to reduce pathogenic contaminants
GB0106953D0 (en) 2001-03-20 2001-05-09 Univ Aberdeen Neufofibrillary labels
GB0113121D0 (en) 2001-05-30 2001-07-18 Univ Leeds Biologically active photosensitisers
US7176308B2 (en) * 2002-06-17 2007-02-13 Verification Technologies, Inc. Processes for preparing novel methylene blue derivative
GB0322756D0 (en) 2003-09-29 2003-10-29 Univ Aberdeen Methods of chemical synthesis
BRPI0416928A (pt) 2003-11-28 2007-01-16 Photopharmica Ltd desenvolvimento de derivados biologicamente ativos de azul de metileno
EP1799662B1 (en) 2004-09-23 2013-04-17 Wista Laboratories Ltd. Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (mtc)
US7790881B2 (en) 2004-09-23 2010-09-07 Wista Laboratories Ltd. Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC)
DE602007008550D1 (de) 2006-03-29 2010-09-30 Wista Lab Ltd 3,7-diamino-10h-phenothiazinsalze und ihre verwendung
EP2457904B1 (en) * 2006-07-11 2014-11-19 Wista Laboratories Ltd. Methods of synthesis and/or purification of diaminophenothiazinium compounds
FR2903696B1 (fr) 2006-07-12 2011-02-11 Provence Technologies Procede de purification de composes diaminophenothiazium
AU2011358840B2 (en) 2011-02-11 2017-05-04 TauRx Therapeutics Management Ltd Phenothiazine diaminium salts and their use
HRP20230628T1 (hr) 2016-07-25 2023-09-29 Wista Laboratories Ltd. Primjena i doziranje diaminofenotiazina
GB201614834D0 (en) 2016-09-01 2016-10-19 Wista Lab Ltd Treatment of dementia
GB201621817D0 (en) 2016-12-21 2017-02-01 Wista Lab Ltd Methods of chemical synthesis
PT3826639T (pt) 2018-07-26 2024-10-09 Wista Lab Ltd Dosagem otimizada de diaminofenotiazinas em populações
GB201909454D0 (en) 2019-07-01 2019-08-14 Wista Lab Ltd Enhancers
GB201909506D0 (en) 2019-07-02 2019-08-14 Wista Lab Ltd Synaptopathies

Also Published As

Publication number Publication date
ES2912571T3 (es) 2022-05-26
EP4063354A1 (en) 2022-09-28
WO2008007074A3 (en) 2008-02-28
US9675621B2 (en) 2017-06-13
ES2603783T3 (es) 2017-03-01
US9980971B2 (en) 2018-05-29
PT2057136E (pt) 2013-08-28
JP2009542786A (ja) 2009-12-03
EP2457904A1 (en) 2012-05-30
PL2457905T3 (pl) 2017-02-28
US20180263999A1 (en) 2018-09-20
MY148145A (en) 2013-03-15
PL2457904T3 (pl) 2015-04-30
EP2057136B1 (en) 2013-05-22
US10525061B2 (en) 2020-01-07
EP3121169A1 (en) 2017-01-25
EP2457904B1 (en) 2014-11-19
DK3121169T3 (da) 2022-02-28
PT3121169T (pt) 2022-05-13
CA2657352C (en) 2019-06-11
PL3121169T3 (pl) 2022-05-23
MY162313A (en) 2017-05-31
JP6243659B2 (ja) 2017-12-06
US20110294795A1 (en) 2011-12-01
US20130317012A1 (en) 2013-11-28
ES2529714T3 (es) 2015-02-24
US8440821B2 (en) 2013-05-14
LT2457905T (lt) 2016-11-10
SI2457905T1 (sl) 2016-12-30
CN101511803B (zh) 2012-10-31
HUE030621T2 (en) 2017-05-29
SI2457904T1 (sl) 2015-02-27
CN102718730A (zh) 2012-10-10
SI2057136T1 (sl) 2013-09-30
WO2008007074A2 (en) 2008-01-17
EP2057136A2 (en) 2009-05-13
US9382220B2 (en) 2016-07-05
DK2457904T3 (da) 2015-01-12
PL2057136T3 (pl) 2013-10-31
AU2007274057B2 (en) 2012-12-13
CY1118184T1 (el) 2017-06-28
EP2457905A1 (en) 2012-05-30
CN102718730B (zh) 2018-06-05
US20170273986A1 (en) 2017-09-28
PT2457904E (pt) 2015-02-27
AU2007274057A1 (en) 2008-01-17
US11878021B2 (en) 2024-01-23
SI3121169T1 (sl) 2022-05-31
US20250222006A1 (en) 2025-07-10
JP5350237B2 (ja) 2013-11-27
US20200261465A1 (en) 2020-08-20
CA2657352A1 (en) 2008-01-17
JP2013253095A (ja) 2013-12-19
HK1129675A1 (en) 2009-12-04
EP3121169B1 (en) 2022-02-09
US20240115580A1 (en) 2024-04-11
DK2457905T3 (da) 2016-11-28
US11045477B2 (en) 2021-06-29
CN101511803A (zh) 2009-08-19
US20160296531A1 (en) 2016-10-13
ES2421930T3 (es) 2013-09-06
EP2457905B1 (en) 2016-08-17
PT2457905T (pt) 2016-11-24
US7956183B2 (en) 2011-06-07
US20210322435A1 (en) 2021-10-21
US20090259040A1 (en) 2009-10-15

Similar Documents

Publication Publication Date Title
DK2057136T3 (da) Fremgangsmåde til syntese og/eller oprensning af diaminophenothiazinium forbindelser
DK1824475T3 (da) Fremgangsmåde til oprensning af trans-(-)-delta9-tetrahydrocannabinol og trans-(+)-delta9-tetrahydrocannabinol
DK2207779T3 (da) Fremgangsmåde til syntese af morpholinooligomerer
DK1893586T3 (da) Fremgangsmåde til fremstilling af 1-alkyl-3-phenyluraciler
DK2086944T3 (da) Fremgangsmåde til fremstilling af difluormethylpyrazolylcarboxylater
DK2081669T3 (da) Fremgangsmåde og anordning til fremstilling af granulater
DK2431359T3 (da) Fremgangsmåde til fremstilling af diaminophenothiaziniumforbindelser
DK2178863T3 (da) Fremgangsmåde til syntetisering af anvendelige forbindelser til behandling af hepatitis C
DK1795576T3 (da) Fremgangsmåde til fremstilling af carbonhydrider
DK2292607T3 (da) Fremgangsmåde til syntese af organiske forbindelser
DK1828164T3 (da) Fremgangsmåde til fremstilling af N-phenylpyrazol-1-carboxamider
DK1778668T3 (da) Fremgangsmåde til fremstilling af dihydropteridion
DK2044028T3 (da) Cyanoisoquinolinforbindelser til stabilisering af den hypoxiinducerende faktor (HIF)
DK2781593T3 (da) Fremgangsmåde til behandling af methanemissioner
DK2048941T3 (da) Fremgangsmåde til opdræt af rovmider
DK1974806T3 (da) Fremgangsmåde til rensning af vand
DK2061803T4 (da) Fremgangsmåde til oprensning af fc-holdige proteiner
EP2019118A4 (en) METHOD FOR SYNTHETIZING THYMOSINS
DK1685834T3 (da) Anvendelse af pinolensyre til behandling af obesitet
DK2178900T3 (da) Oprensning af pegylerede polypeptider
DK1948176T3 (da) Diarylurinstoffer til behandling af pulmonær hypertension
DK2373400T3 (da) Fremgangsmåde til rensning af gasser og udvinding af syregasser
DK2379491T3 (da) Fremgangsmåde til syntese af amino-methyl-tetralinderivater
DK1963251T3 (da) Fremgangsmåde til fremstilling af aminer
DK1831223T3 (da) Fremgangsmåde til fremstilling af L-biopterin