BRPI0416928A - desenvolvimento de derivados biologicamente ativos de azul de metileno - Google Patents

desenvolvimento de derivados biologicamente ativos de azul de metileno

Info

Publication number
BRPI0416928A
BRPI0416928A BRPI0416928-0A BRPI0416928A BRPI0416928A BR PI0416928 A BRPI0416928 A BR PI0416928A BR PI0416928 A BRPI0416928 A BR PI0416928A BR PI0416928 A BRPI0416928 A BR PI0416928A
Authority
BR
Brazil
Prior art keywords
biologically active
phenothiazine
compounds
methylene blue
conjugate
Prior art date
Application number
BRPI0416928-0A
Other languages
English (en)
Inventor
Stanley Beames Brown
Cassandra Claire O'grady
John Griffiths
Kirste Joanne Mellish
Richard George Tunstall
David John Howard Roberts
David Ian Vernon
Original Assignee
Photopharmica Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0327672.2A external-priority patent/GB0327672D0/en
Priority claimed from GB0329809A external-priority patent/GB0329809D0/en
Application filed by Photopharmica Ltd filed Critical Photopharmica Ltd
Publication of BRPI0416928A publication Critical patent/BRPI0416928A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

"DESENVOLVIMENTOS DE DERIVADOS BIOLOGICAMENTE ATIVOS DE AZUL DE METILENO". Um composto fenotiazina de Fórmula (I) para uso como um agente antimicrobiano para a prevenção de infecções microbianas em que: cada R1, R2, R3 e R4 independentemente é um substituto opcionalmente linear, ramificado ou grupo hidrocarbono cíclico; ou R1 e R2 ou R3 e R4 juntos com o átomo de N ao qual eles estão ligados formam um anel de 5-, 6- ou 7- membros opcionalmente substituídos; X¬ p-¬ é um contra íon; e P é 1, 2 ou 3. A invenção também relaciona-se a composições compreendendo compostos fenotiazina para selecionar compostos e seu uso como medicamentos, como agentes PDT, como agentes fotodiagnósticos, para um conjugato ou compósite formada entre um fenotiazina e um polímero; e a um método para esterilizar fluidos em que o fluido passa através do conjugado ou compósite enquanto ele é iluminado. Os compostos são fotossensibilizantes biologicamente ativos que são fortemente fotocitotóxicos e têm aplicação nas áreas de terapia fotodinâmica (PDT), bem como para o diagnóstico e detecção de condições médicas e usos relacionados em internalização fotoquímica, na produção de vacinas de câncer, no tratamento e prevenção de infecções microbianas e em fotodesinfecção ou fotoesterilização.
BRPI0416928-0A 2003-11-28 2004-11-22 desenvolvimento de derivados biologicamente ativos de azul de metileno BRPI0416928A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0327672.2A GB0327672D0 (en) 2003-11-28 2003-11-28 Developments in biologically active methylene blue derivatives (phenothiazines)
GB0329809A GB0329809D0 (en) 2003-12-23 2003-12-23 Developments in biologically active methylene blue derivatives (2) (phenothiazines)
PCT/GB2004/004918 WO2005054217A1 (en) 2003-11-28 2004-11-22 Developments in biologically active methylene blue derivatives (2)

Publications (1)

Publication Number Publication Date
BRPI0416928A true BRPI0416928A (pt) 2007-01-16

Family

ID=34655223

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0416928-0A BRPI0416928A (pt) 2003-11-28 2004-11-22 desenvolvimento de derivados biologicamente ativos de azul de metileno

Country Status (7)

Country Link
EP (1) EP1687286A1 (pt)
JP (1) JP2007512297A (pt)
KR (1) KR20060111536A (pt)
AU (1) AU2004295148A1 (pt)
BR (1) BRPI0416928A (pt)
CA (1) CA2547556A1 (pt)
WO (1) WO2005054217A1 (pt)

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FR2920775B1 (fr) * 2007-09-07 2009-11-06 Pharma Hydro Dev P H D Soc Par Nouveaux composes diaminophenothiazine, leur procede de preparation et leurs utilisations.
GB2453564A (en) * 2007-10-11 2009-04-15 Liverpool John Moores University Ring-fused derivatives of 3,7-diamino- phenothiazinium & phenoselenazinium salts for use as antimicrobial agents
CN102958525B (zh) * 2010-04-30 2017-05-24 普罗瑟塔抗病毒股份有限公司 抗病毒化合物
US8759336B2 (en) 2011-03-17 2014-06-24 Prosetta Antiviral Inc. Antiviral compounds
WO2012085257A1 (en) * 2010-12-22 2012-06-28 Ortner Cleanroom Engineering Gmbh Photodynamic control of microbial growth on surfaces
WO2012085250A1 (en) * 2010-12-22 2012-06-28 Ortner Cleanroom Engineering Gmbh Clean room device with movable electromagnetic radiation source
DK2673266T3 (en) 2011-02-11 2016-10-24 Wista Lab Ltd Phenothiazine DIAMINIUM SALTS AND USE THEREOF
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WO2012145567A1 (en) 2011-04-20 2012-10-26 Prosetta Antiviral Inc. Antiviral compounds
US20120301904A1 (en) 2011-04-26 2012-11-29 Prosetta Antiviral, Inc Multiprotein assemblies
US9226038B2 (en) 2012-11-12 2015-12-29 Roger B. and Ann K. McNamee Trust U/T/A/D Systems and methods for communicating a live event to users using the internet
JP6111381B2 (ja) * 2013-08-15 2017-04-05 ユーファーマ ピーティーワイ リミテッド ジアミノフェノチアジニウム化合物の精製方法
WO2016031875A1 (ja) 2014-08-27 2016-03-03 富士フイルム株式会社 光線力学療法用組成物、殺菌方法、殺菌システムおよび殺菌システムの作動方法
WO2017116903A1 (en) 2015-12-28 2017-07-06 Frangioni, John, V. Method of preparing diaminophenothiazinium
FR3063495B1 (fr) * 2017-03-02 2019-04-05 Provepharm Life Solutions Procede de preparation de l’iodure de 3,7-bis(dimethylamino)phenothiazine-5-ylium
WO2019032683A2 (en) * 2017-08-08 2019-02-14 Board Of Trustees Of Michigan State University LIGHT-EMITTING ORGANIC SALTS FOR ENHANCED PHOTODYNAMIC THERAPY AND IMAGING
US20220049102A1 (en) 2019-09-21 2022-02-17 RK Pharma Solutions LLC Process for the Purification of Methylene Blue

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Also Published As

Publication number Publication date
AU2004295148A1 (en) 2005-06-16
EP1687286A1 (en) 2006-08-09
CA2547556A1 (en) 2005-06-16
KR20060111536A (ko) 2006-10-27
JP2007512297A (ja) 2007-05-17
WO2005054217A1 (en) 2005-06-16

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Legal Events

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B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.