ITMI20072262A1 - Procedimento per la preparazione di acido (s)(+)-3-(amminometil)-5-metilesanoico - Google Patents

Procedimento per la preparazione di acido (s)(+)-3-(amminometil)-5-metilesanoico

Info

Publication number
ITMI20072262A1
ITMI20072262A1 IT002262A ITMI20072262A ITMI20072262A1 IT MI20072262 A1 ITMI20072262 A1 IT MI20072262A1 IT 002262 A IT002262 A IT 002262A IT MI20072262 A ITMI20072262 A IT MI20072262A IT MI20072262 A1 ITMI20072262 A1 IT MI20072262A1
Authority
IT
Italy
Prior art keywords
methylesanoic
aminomethyl
procedure
preparation
acid
Prior art date
Application number
IT002262A
Other languages
English (en)
Inventor
Pietro Allegrini
Simone Mantegazza
Dario Pastorello
Gabriele Razzetti
Original Assignee
Dipharma Francis Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dipharma Francis Srl filed Critical Dipharma Francis Srl
Priority to IT002262A priority Critical patent/ITMI20072262A1/it
Priority to CA002644624A priority patent/CA2644624A1/en
Priority to EP08169835A priority patent/EP2067768A1/en
Priority to US12/327,191 priority patent/US20090143615A1/en
Publication of ITMI20072262A1 publication Critical patent/ITMI20072262A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C243/28—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT002262A 2007-12-03 2007-12-03 Procedimento per la preparazione di acido (s)(+)-3-(amminometil)-5-metilesanoico ITMI20072262A1 (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IT002262A ITMI20072262A1 (it) 2007-12-03 2007-12-03 Procedimento per la preparazione di acido (s)(+)-3-(amminometil)-5-metilesanoico
CA002644624A CA2644624A1 (en) 2007-12-03 2008-11-24 A process for the preparation of (s)(+)-3-(aminomethyly)-5-methylhexanoic acid
EP08169835A EP2067768A1 (en) 2007-12-03 2008-11-25 A process for the preparation of (S)(+)-3-(aminomethyl)-5-methylhexanoic acid
US12/327,191 US20090143615A1 (en) 2007-12-03 2008-12-03 Process for the Preparation of (S)(+)-3-(Aminomethyl)-5-Methylhexanoic Acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT002262A ITMI20072262A1 (it) 2007-12-03 2007-12-03 Procedimento per la preparazione di acido (s)(+)-3-(amminometil)-5-metilesanoico

Publications (1)

Publication Number Publication Date
ITMI20072262A1 true ITMI20072262A1 (it) 2009-06-04

Family

ID=40315522

Family Applications (1)

Application Number Title Priority Date Filing Date
IT002262A ITMI20072262A1 (it) 2007-12-03 2007-12-03 Procedimento per la preparazione di acido (s)(+)-3-(amminometil)-5-metilesanoico

Country Status (4)

Country Link
US (1) US20090143615A1 (it)
EP (1) EP2067768A1 (it)
CA (1) CA2644624A1 (it)
IT (1) ITMI20072262A1 (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE523484T1 (de) * 2005-05-10 2011-09-15 Teva Pharma Optische lösung a us 3-carbamoylmethyl-5-methyl- hexansäure
ES2398579T3 (es) 2005-09-19 2013-03-20 Teva Pharmaceutical Industries Ltd Una síntesis asimétrica de ácido (S)-(+)-3-(aminometil)-5-metilhexanoico
EP1904486A2 (en) * 2006-04-24 2008-04-02 Teva Pharmaceutical Industries Ltd Processes for the synthesis of 3-isobutylglutaric acid
WO2007143113A2 (en) * 2006-05-31 2007-12-13 Teva Pharmaceutical Industries Ltd. The use of enzymatic resolution for the preparation of intermediates of pregabalin
US8097754B2 (en) 2007-03-22 2012-01-17 Teva Pharmaceutical Industries Ltd. Synthesis of (S)-(+)-3-(aminomethyl)-5-methyl hexanoic acid
WO2009046309A2 (en) * 2007-10-03 2009-04-09 Teva Pharmaceutical Industries Ltd. Pregabalin -4-eliminate, pregabalin 5-eliminate, their use as reference marker and standard, and method to produce pregabalin containing low levels thereof
WO2011071520A1 (en) * 2009-12-07 2011-06-16 Dissymmetrix (Pvt) Ltd. Processes for the preparation of (s)-3-(aminomethyl)-5-methylhexanoic acid
CN102690207B (zh) * 2012-05-31 2014-03-26 湖北楚阳科技股份有限公司 一种加巴喷丁的合成方法
CA2888877C (en) 2012-11-07 2021-07-27 Hikal Limited A process for the preparation of pregabalin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197819B1 (en) 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
US5616793A (en) * 1995-06-02 1997-04-01 Warner-Lambert Company Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid
US5637767A (en) 1995-06-07 1997-06-10 Warner-Lambert Company Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
GB2365425A (en) * 2000-08-01 2002-02-20 Parke Davis & Co Ltd Alkyl amino acid derivatives useful as pharmaceutical agents
US8048917B2 (en) * 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
EA015418B1 (ru) 2004-06-21 2011-08-30 УОРНЕР-ЛАМБЕРТ КОМПАНИ ЭлЭлСи Получение прегабалина и родственных соединений
CN1634869A (zh) 2004-12-06 2005-07-06 北京阜康仁生物制药科技有限公司 普瑞巴林新晶型及其制备方法

Also Published As

Publication number Publication date
EP2067768A1 (en) 2009-06-10
US20090143615A1 (en) 2009-06-04
CA2644624A1 (en) 2009-06-03

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