NO20045037L - Fremgangsmate for fremstilling av atorvastatin-kalsium i amorf form - Google Patents
Fremgangsmate for fremstilling av atorvastatin-kalsium i amorf formInfo
- Publication number
- NO20045037L NO20045037L NO20045037A NO20045037A NO20045037L NO 20045037 L NO20045037 L NO 20045037L NO 20045037 A NO20045037 A NO 20045037A NO 20045037 A NO20045037 A NO 20045037A NO 20045037 L NO20045037 L NO 20045037L
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- amorphous form
- atorvastatin calcium
- atorvastatin
- calcium
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN491DE2004 | 2004-03-17 |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20045037D0 NO20045037D0 (no) | 2004-11-19 |
NO20045037L true NO20045037L (no) | 2005-09-19 |
NO330092B1 NO330092B1 (no) | 2011-02-14 |
Family
ID=33516010
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20045037A NO330092B1 (no) | 2004-03-17 | 2004-11-19 | Fremgangsmate for fremstilling av atorvastatin-kalsium i amorf form |
Country Status (17)
Country | Link |
---|---|
US (1) | US7994343B2 (no) |
EP (3) | EP1577297A1 (no) |
CN (2) | CN1942439B (no) |
AR (1) | AR048271A1 (no) |
AT (1) | ATE545629T1 (no) |
AU (2) | AU2004317570B2 (no) |
CA (3) | CA2560252C (no) |
CY (1) | CY1112583T1 (no) |
DK (1) | DK1727795T3 (no) |
ES (1) | ES2381473T3 (no) |
FI (1) | FI120344B (no) |
MY (1) | MY147435A (no) |
NO (1) | NO330092B1 (no) |
PL (1) | PL1727795T3 (no) |
PT (1) | PT1727795E (no) |
SI (1) | SI1727795T1 (no) |
WO (1) | WO2005092852A1 (no) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI1727795T1 (sl) * | 2004-03-17 | 2012-05-31 | Ranbaxy Lab Ltd | Postopek za pripravo atorvastatin kalcija v amorfni obliki |
EP1771455B1 (en) * | 2004-07-16 | 2016-05-11 | LEK Pharmaceuticals d.d. | Oxidative degradation products of atorvastatin calcium |
EP1784389A4 (en) * | 2004-08-27 | 2009-03-25 | Biocon Ltd | PROCESS FOR THE PREPARATION OF AMORPHIC ATORVASTATIN CALCIUM |
GB2424880A (en) * | 2005-04-06 | 2006-10-11 | Generics | Crystalline forms of atorvastatin sodium, processes for their preparation and their use in inhibiting HMG-CoA reductase |
GB0613567D0 (en) * | 2006-07-07 | 2006-08-16 | Arrow Int Ltd | Crystalline sodium atorvastatin |
CA2619040C (en) | 2005-08-15 | 2015-02-10 | Arrow International Limited | Crystalline and amorphous sodium atorvastatin |
GB0613566D0 (en) * | 2006-07-07 | 2006-08-16 | Arrow Int Ltd | Crystalline sodium atorvastatin |
CA2619486C (en) | 2005-08-15 | 2015-05-12 | Arrow International Limited | Crystalline and amorphous sodium atorvastatin |
ES2270722B1 (es) * | 2005-09-15 | 2008-03-01 | Ercros Industrial, S.A. | Procedimiento para la obtencion de atorvastatina calcica amorfa. |
GB0523637D0 (en) * | 2005-11-21 | 2005-12-28 | Avecia Pharmaceuticals Ltd | Process and compounds |
WO2007099552A2 (en) * | 2006-03-02 | 2007-09-07 | Matrix Labaratories Ltd | Novel crystalline form of atovastatin hemi-magnesium |
SI22255A (sl) * | 2006-04-14 | 2007-10-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Novi polimorfi statinovih soli in njihova uporabav farmacevtskih formulacijah |
CN101205209B (zh) * | 2007-12-25 | 2010-06-02 | 浙江新东港药业股份有限公司 | 一种阿伐他汀中间体的精制方法 |
EP2075246A1 (en) * | 2007-12-27 | 2009-07-01 | M. J. Institute of Research | A process for preparation of amorphous form of atorvastatin hemi-calcium salt |
CN101468963B (zh) * | 2007-12-28 | 2012-09-19 | 石药集团中奇制药技术(石家庄)有限公司 | 一种无定形阿伐他汀钙的制备方法 |
KR100850558B1 (ko) * | 2008-01-02 | 2008-08-06 | 조동옥 | 아토르바스타틴의 효율적인 제조방법 |
CN101560177B (zh) * | 2008-04-16 | 2012-10-03 | 北京万全阳光医学技术有限公司 | 一种阿托伐他汀钙的制备方法 |
CN101429195B (zh) * | 2008-11-03 | 2010-12-15 | 华东师范大学 | 一种高纯度阿托伐他汀重要合成中间体的制备方法 |
US8115015B2 (en) | 2009-01-26 | 2012-02-14 | Cadila Healthcare Limited | Process for the preparation of amorphous atorvastatin calcium |
US20130041162A1 (en) * | 2010-04-19 | 2013-02-14 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Production of atorvastatin low in ether impurities |
CN102127060B (zh) * | 2010-12-17 | 2013-12-04 | 蚌埠丰原医药科技发展有限公司 | 一种阿托伐他汀钙中间体的制备方法 |
CN102070504A (zh) * | 2010-12-23 | 2011-05-25 | 蚌埠丰原医药科技发展有限公司 | 阿托伐他汀钠的制备方法 |
CN102070505B (zh) * | 2011-01-28 | 2012-01-11 | 海南美大制药有限公司 | 阿托伐他汀钙化合物及其新制法 |
CN103483238B (zh) * | 2013-08-20 | 2014-12-31 | 蚌埠丰原医药科技发展有限公司 | 阿托伐他汀钙三水合物的制备方法 |
CN104945300B (zh) * | 2015-06-17 | 2017-05-10 | 北京嘉林药业股份有限公司 | 一种ⅰ型阿托伐他汀钙的纯化方法 |
WO2017060885A1 (en) * | 2015-10-09 | 2017-04-13 | Laurus Labs Private Limited | An improved process for preparation of atorvastatin or pharmaceutically acceptable salts thereof |
CN106478591B (zh) * | 2016-09-30 | 2018-11-13 | 北京嘉林药业股份有限公司 | 一种阿托伐他汀缩合物中间体的拆分方法 |
CN106432033B (zh) * | 2016-10-21 | 2018-07-27 | 江苏阿尔法药业有限公司 | 一种无定形阿托伐他汀钙的制备方法 |
CN108033899B (zh) * | 2017-12-06 | 2020-04-10 | 浙江科技学院 | 一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法 |
CN109232355A (zh) * | 2018-10-09 | 2019-01-18 | 河南师范大学 | 一种有效去除阿托伐他汀钙粗品中杂质阿托伐他汀缩合物的方法 |
CN109280024A (zh) * | 2018-10-09 | 2019-01-29 | 河南师范大学 | 一种高纯度阿托伐他汀叔丁酯的制备方法 |
CN110563628B (zh) * | 2019-08-26 | 2022-04-05 | 北京嘉林药业股份有限公司 | 一种双釜制备高纯度和单分散i晶型阿托伐他汀钙的结晶方法 |
CN110776451B (zh) * | 2020-01-02 | 2020-05-22 | 湖南迪诺制药股份有限公司 | 一种i晶型阿托伐他汀钙的制备方法 |
CN113695307B (zh) * | 2020-05-20 | 2022-12-02 | 天津嘉林科医有限公司 | 一种盛放阿托伐他汀钙的玻璃器皿的清洗方法 |
Family Cites Families (36)
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US5097045A (en) | 1989-02-01 | 1992-03-17 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
US5245047A (en) | 1988-02-22 | 1993-09-14 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
US5003080A (en) | 1988-02-22 | 1991-03-26 | Warner-Lambert Company | Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis |
US5124482A (en) | 1988-02-22 | 1992-06-23 | Warner-Lambert Company | Process for trans-6-(2-substituted-pyrrol-1-yl)alkyl)pyran-2-one inhibitors of cholesterol synthesis |
US5216174A (en) | 1988-02-22 | 1993-06-01 | Warner-Lambert Co. | Process for trans-6-[12-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
US5149837A (en) | 1988-02-22 | 1992-09-22 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
US5248793A (en) | 1990-10-17 | 1993-09-28 | Warner-Lambert Company | Process for the synthesis of (4R-cis)-1,1-dimethylethyl 6-iodomethyl or 6-(phenyl-substituted)sulfonyloxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate |
US5103024A (en) | 1990-10-17 | 1992-04-07 | Warner-Lambert Company | Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate |
US5155251A (en) | 1991-10-11 | 1992-10-13 | Warner-Lambert Company | Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate |
WO1994016693A1 (en) | 1993-01-19 | 1994-08-04 | Warner-Lambert Company | Stable oral ci-981 formulation and process of preparing same |
US5298627A (en) | 1993-03-03 | 1994-03-29 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
HRP960312B1 (en) * | 1995-07-17 | 2001-10-31 | Warner Lambert Co | NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS /R-(R*, R*)/-2-(4-FLUOROPHENYL)-"beta", "delta"-DIHYDROXY-5-PHENYL-4-/(PHENYLAMINO)CARBONYL/-1H-PYRROLE -1-HEPTANOIC ACID CALCIUM SALT (2 : 1) |
IL122118A (en) | 1995-07-17 | 1999-07-14 | Warner Lambert Co | Crystalline form I atorvastatin pharmaceutical compositions containing it and process for its preparation |
IN191236B (no) | 1999-05-25 | 2003-10-11 | Ranbaxy Lab Ltd | |
US6646133B1 (en) * | 2000-10-17 | 2003-11-11 | Egis Gyogyszergyar Rt. | Process for the preparation of amorphous atorvastatin calcium |
HU226640B1 (en) | 1999-10-18 | 2009-05-28 | Egis Gyogyszergyar Nyilvanosan | Process for producing amorphous atorvastatin calcium salt |
SI20425A (sl) * | 1999-12-10 | 2001-06-30 | LEK tovarna farmacevtskih in kemi�nih izdelkov d.d. | Priprava amorfnega atorvastatina |
SK16982002A3 (sk) | 2000-06-09 | 2003-04-01 | Lek Pharmaceuticals D. D. | Stabilizovaná farmaceuticky účinná kompozícia a liečivý prípravok túto kompozíciu obsahujúci |
US6605636B2 (en) | 2000-11-03 | 2003-08-12 | Teva Pharmaceutical Industries Ltd. | Atorvastatin hemi-calcium form VII |
IL156055A0 (en) | 2000-11-30 | 2003-12-23 | Teva Pharma | Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms |
WO2002057225A2 (en) | 2000-12-18 | 2002-07-25 | Merck & Co., Inc. | Thrombin inhibitors |
CN1273449C (zh) | 2000-12-27 | 2006-09-06 | 特瓦制药工业有限公司 | 阿伐他汀的晶型 |
WO2002057228A1 (en) | 2001-01-17 | 2002-07-25 | Biocon India Limited | Atorvastatin calcium |
SI20814A (sl) | 2001-01-23 | 2002-08-31 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Priprava amorfnega atorvastatina |
IN190564B (no) | 2001-04-11 | 2003-08-09 | Cadila Heathcare Ltd | |
MXPA03010266A (es) | 2001-06-29 | 2004-03-10 | Warner Lambert Co | Formas cristalinas de la sal de calcio del acido [r-(r*, r*)]-2 -(4-fluorofenil)-¦, d-dihidroxi-5 -(1-metiletil)-3 -fenil-4- [(fenilamino) carbonil ]-1h- pirrol-1-heptanoico (2:1) (atorvastatin). |
JP2005500351A (ja) | 2001-07-30 | 2005-01-06 | ドクター・レディーズ・ラボラトリーズ・リミテッド | 結晶形態viおよびviiのアトルバスタチンカルシウム |
AU2001284385A1 (en) | 2001-08-31 | 2003-03-10 | Morepen Laboratories Ltd. | An improved process for the preparation of amorphous atorvastatin calcium salt (2:1) |
CZ296967B6 (cs) * | 2002-02-01 | 2006-08-16 | Zentiva, A.S. | Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu) |
ES2338530T3 (es) | 2002-03-18 | 2010-05-10 | Biocon Limited | Inhibidores de hmg-coa reductasa amorfos del tamaño de particulas deseado. |
WO2003099785A1 (en) | 2002-05-28 | 2003-12-04 | Cadila Healthcare Limited | Process for the preparation of amorphous atorvastatin calcium |
SI21302A (sl) | 2002-10-11 | 2004-04-30 | LEK farmacevtska dru�ba d.d. | Stabiliziran farmacevtski izdelek z amorfno aktivno učinkovino |
HU227041B1 (en) | 2003-03-24 | 2010-05-28 | Richter Gedeon Nyrt | Process for the synthesis of amorphous atorvastatin calcium |
SI1727795T1 (sl) * | 2004-03-17 | 2012-05-31 | Ranbaxy Lab Ltd | Postopek za pripravo atorvastatin kalcija v amorfni obliki |
TWI321132B (en) | 2004-09-28 | 2010-03-01 | Teva Pharma | Process for preparing forms of atorvastatin calcium substantially free of impurities |
-
2004
- 2004-11-19 SI SI200431843T patent/SI1727795T1/sl unknown
- 2004-11-19 PL PL04798913T patent/PL1727795T3/pl unknown
- 2004-11-19 US US10/549,890 patent/US7994343B2/en not_active Expired - Fee Related
- 2004-11-19 EP EP04027584A patent/EP1577297A1/en not_active Withdrawn
- 2004-11-19 CA CA002560252A patent/CA2560252C/en not_active Expired - Fee Related
- 2004-11-19 ES ES04798913T patent/ES2381473T3/es active Active
- 2004-11-19 NO NO20045037A patent/NO330092B1/no not_active IP Right Cessation
- 2004-11-19 EP EP04798913A patent/EP1727795B1/en active Active
- 2004-11-19 AU AU2004317570A patent/AU2004317570B2/en not_active Ceased
- 2004-11-19 PT PT04798913T patent/PT1727795E/pt unknown
- 2004-11-19 CA CA002666359A patent/CA2666359A1/en not_active Abandoned
- 2004-11-19 CA CA002627940A patent/CA2627940A1/en not_active Abandoned
- 2004-11-19 DK DK04798913.2T patent/DK1727795T3/da active
- 2004-11-19 AT AT04798913T patent/ATE545629T1/de active
- 2004-11-19 WO PCT/IB2004/003789 patent/WO2005092852A1/en active Application Filing
- 2004-11-19 FI FI20041489A patent/FI120344B/fi not_active IP Right Cessation
- 2004-11-19 CN CN2004800428343A patent/CN1942439B/zh not_active Expired - Fee Related
-
2005
- 2005-03-16 AR ARP050101018A patent/AR048271A1/es unknown
- 2005-03-17 CN CNA200580012704XA patent/CN1946688A/zh active Pending
- 2005-03-17 MY MYPI20051161A patent/MY147435A/en unknown
- 2005-09-16 EP EP05077109A patent/EP1659110A1/en not_active Ceased
-
2010
- 2010-12-03 AU AU2010249166A patent/AU2010249166B2/en not_active Ceased
-
2012
- 2012-04-04 CY CY20121100335T patent/CY1112583T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU2004317570A1 (en) | 2005-10-06 |
CA2560252C (en) | 2009-08-04 |
WO2005092852A1 (en) | 2005-10-06 |
EP1577297A1 (en) | 2005-09-21 |
SI1727795T1 (sl) | 2012-05-31 |
EP1727795A1 (en) | 2006-12-06 |
AR048271A1 (es) | 2006-04-12 |
CN1942439B (zh) | 2011-12-21 |
EP1727795B1 (en) | 2012-02-15 |
NO20045037D0 (no) | 2004-11-19 |
EP1659110A1 (en) | 2006-05-24 |
MY147435A (en) | 2012-12-14 |
DK1727795T3 (da) | 2012-04-16 |
CA2627940A1 (en) | 2005-10-06 |
CA2560252A1 (en) | 2005-10-06 |
AU2004317570B2 (en) | 2011-01-06 |
CY1112583T1 (el) | 2016-02-10 |
ES2381473T3 (es) | 2012-05-28 |
ATE545629T1 (de) | 2012-03-15 |
CA2666359A1 (en) | 2005-10-06 |
CN1946688A (zh) | 2007-04-11 |
US20100197941A1 (en) | 2010-08-05 |
FI20041489A (fi) | 2006-07-20 |
US7994343B2 (en) | 2011-08-09 |
FI20041489A0 (fi) | 2004-11-19 |
NO330092B1 (no) | 2011-02-14 |
AU2010249166A1 (en) | 2010-12-23 |
FI120344B (fi) | 2009-09-30 |
CN1942439A (zh) | 2007-04-04 |
PL1727795T3 (pl) | 2012-06-29 |
PT1727795E (pt) | 2012-04-11 |
AU2010249166B2 (en) | 2012-02-09 |
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Legal Events
Date | Code | Title | Description |
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MM1K | Lapsed by not paying the annual fees |