EA200100807A1 - Производные алкинилсодержащих гидроксамовых кислот и их применение в качестве ингибиторов tace - Google Patents

Производные алкинилсодержащих гидроксамовых кислот и их применение в качестве ингибиторов tace

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Publication number
EA200100807A1
EA200100807A1 EA200100807A EA200100807A EA200100807A1 EA 200100807 A1 EA200100807 A1 EA 200100807A1 EA 200100807 A EA200100807 A EA 200100807A EA 200100807 A EA200100807 A EA 200100807A EA 200100807 A1 EA200100807 A1 EA 200100807A1
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EA
Eurasian Patent Office
Prior art keywords
alkinyl
derivatives
hydroxamic acids
tace inhibitors
containing hydroxamic
Prior art date
Application number
EA200100807A
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English (en)
Other versions
EA004883B1 (ru
Inventor
Джереми Ян Левин
Аранапакам Мудумбай Венкатесан
Дерек Сесил Коул
Джеймс Минг Чен
Джэми Мэри Дэвис
Джордж Теодор Гросу
Original Assignee
Американ Цианамид Компани
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Publication date
Application filed by Американ Цианамид Компани filed Critical Американ Цианамид Компани
Publication of EA200100807A1 publication Critical patent/EA200100807A1/ru
Publication of EA004883B1 publication Critical patent/EA004883B1/ru

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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
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Abstract

Настоящее изобретение относится к соединениям формулы (I), которые пригодны для лечения заболеваний, опосредованных ФНО-α, таких как ревматоидный артрит, остеоартрит, сепсис, СПИД, неспецифический язвенный колит, рассеянный склероз, болезнь Крона и дегенеративное разрежение хряща.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100807A 1999-01-27 2000-01-27 Производные алкинилсодержащих гидроксамовых кислот и их применение в качестве ингибиторов tace EA004883B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23908899A 1999-01-27 1999-01-27
PCT/US2000/002078 WO2000044713A1 (en) 1999-01-27 2000-01-27 Alkynyl containing hydroxamic acid compounds as tace inhibitors

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EA200100807A1 true EA200100807A1 (ru) 2002-08-29
EA004883B1 EA004883B1 (ru) 2004-08-26

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Families Citing this family (14)

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GB9918684D0 (en) * 1999-08-09 1999-10-13 Novartis Ag Organic compounds
DE10015533A1 (de) * 1999-11-30 2001-06-28 Rohmax Additives Gmbh Blockcopolymere sowie Verfahren zur Hestellung und Verwendung
US7569724B2 (en) 2000-09-29 2009-08-04 Topotarget Uk Limited Carbamic acid compounds comprising an amide linkage as HDAC inhibitors
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HK1037611A1 (en) 2002-02-15
NO20013677D0 (no) 2001-07-26
CZ20012707A3 (cs) 2002-05-15
IL144348A0 (en) 2002-05-23
CA2356346A1 (en) 2000-08-03
NO20013677L (no) 2001-09-20
AU767754B2 (en) 2003-11-20
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AR035311A1 (es) 2004-05-12
DE60012303T2 (de) 2005-07-28
JP2002535384A (ja) 2002-10-22
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EP1147080A1 (en) 2001-10-24
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PT1147080E (pt) 2004-11-30
ZA200105066B (en) 2002-09-20
HUP0200213A2 (en) 2002-06-29
DK1147080T3 (da) 2004-09-27
NZ512446A (en) 2004-02-27
CN1337945A (zh) 2002-02-27
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