AU2002246675A1 - Thrombin inhibitors - Google Patents

Thrombin inhibitors

Info

Publication number
AU2002246675A1
AU2002246675A1 AU2002246675A AU2002246675A AU2002246675A1 AU 2002246675 A1 AU2002246675 A1 AU 2002246675A1 AU 2002246675 A AU2002246675 A AU 2002246675A AU 2002246675 A AU2002246675 A AU 2002246675A AU 2002246675 A1 AU2002246675 A1 AU 2002246675A1
Authority
AU
Australia
Prior art keywords
thrombin inhibitors
thrombin
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002246675A
Inventor
James C. Barrow
Matthew M. Morrissette
Philippe G. Nantermet
Kenneth E. Rittle
Harold G. Selnick
Donnette Staas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU2002246675A1 publication Critical patent/AU2002246675A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AU2002246675A 2000-12-18 2001-12-14 Thrombin inhibitors Abandoned AU2002246675A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25632100P 2000-12-18 2000-12-18
US60/256,321 2000-12-18
PCT/US2001/048673 WO2002057225A2 (en) 2000-12-18 2001-12-14 Thrombin inhibitors

Publications (1)

Publication Number Publication Date
AU2002246675A1 true AU2002246675A1 (en) 2002-07-30

Family

ID=22971808

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002246675A Abandoned AU2002246675A1 (en) 2000-12-18 2001-12-14 Thrombin inhibitors

Country Status (2)

Country Link
AU (1) AU2002246675A1 (en)
WO (1) WO2002057225A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA06006927A (en) * 2003-12-18 2006-08-23 Astrazeneca Ab New 5,6-dihydropyrin-2-one compounds useful as inhibitors of thrombin.
CN1942439B (en) 2004-03-17 2011-12-21 兰贝克赛实验室有限公司 Process for the production of atorvastatin calcium in amorphous form
WO2006135323A1 (en) * 2005-06-17 2006-12-21 Astrazeneca Ab Thrombin inhibiting 2-oxo-1, 2, 5, 6-tetrahydropyridine derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866573A (en) * 1997-04-21 1999-02-02 Merck & Co., Inc. Pyrazinone thrombin inhibitors

Also Published As

Publication number Publication date
WO2002057225A2 (en) 2002-07-25
WO2002057225A3 (en) 2002-09-06

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase