DK32684A - Fremgangsmaade til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol og mellemprodukter til brug herfor - Google Patents
Fremgangsmaade til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol og mellemprodukter til brug herfor Download PDFInfo
- Publication number
- DK32684A DK32684A DK32684A DK32684A DK32684A DK 32684 A DK32684 A DK 32684A DK 32684 A DK32684 A DK 32684A DK 32684 A DK32684 A DK 32684A DK 32684 A DK32684 A DK 32684A
- Authority
- DK
- Denmark
- Prior art keywords
- 1alfa
- dihydroxycholesterol
- hexafluor
- intermediates
- preparing
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title 1
- HIAJCGFYHIANNA-QIZZZRFXSA-N 3b-Hydroxy-5-cholenoic acid Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@@H](CCC(O)=O)C)[C@@]1(C)CC2 HIAJCGFYHIANNA-QIZZZRFXSA-N 0.000 abstract 2
- 229930003316 Vitamin D Natural products 0.000 abstract 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 1
- 239000011612 calcitriol Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 239000011710 vitamin D Substances 0.000 abstract 1
- 235000019166 vitamin D Nutrition 0.000 abstract 1
- 150000003710 vitamin D derivatives Chemical class 0.000 abstract 1
- 229940046008 vitamin d Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nutrition Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38205582 | 1982-05-26 | ||
| US06/382,055 US4411833A (en) | 1982-05-26 | 1982-05-26 | Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol |
| PCT/US1983/000577 WO1983004256A1 (en) | 1982-05-26 | 1983-04-18 | METHOD FOR PREPARING 26,26,26,27,27,27-HEXAFLUORO-1alpha,25-DIHYDROXYCHOLESTEROL |
| US8300577 | 1983-04-18 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK32684D0 DK32684D0 (da) | 1984-01-25 |
| DK32684A true DK32684A (da) | 1984-01-25 |
| DK168539B1 DK168539B1 (da) | 1994-04-18 |
Family
ID=23507359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK032684A DK168539B1 (da) | 1982-05-26 | 1984-01-25 | Speciel fremgangsmåde til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol og mellemprodukter til brug herved |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4411833A (da) |
| JP (2) | JPH0742305B2 (da) |
| AU (1) | AU561182B2 (da) |
| BE (1) | BE896830A (da) |
| CH (2) | CH663212A5 (da) |
| DE (1) | DE3390016C2 (da) |
| DK (1) | DK168539B1 (da) |
| FR (2) | FR2527615B1 (da) |
| GB (2) | GB2121044B (da) |
| IE (1) | IE55022B1 (da) |
| IL (1) | IL68537A (da) |
| IT (1) | IT1203706B (da) |
| NL (1) | NL8320153A (da) |
| WO (1) | WO1983004256A1 (da) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4613594A (en) * | 1984-11-16 | 1986-09-23 | Hoffmann-La Roche Inc. | Fluorinated vitamin D3 compounds |
| US4749710A (en) * | 1985-05-01 | 1988-06-07 | Hoffmann-La Roche Inc. | Immunosuppressive agents |
| US4619920A (en) * | 1985-09-16 | 1986-10-28 | Wisconsin Alumni Research Foundation | 26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D3 |
| JPH0764804B2 (ja) * | 1986-04-25 | 1995-07-12 | 住友製薬株式会社 | 活性型ビタミンｄ３のフッ素誘導体 |
| WO1990009179A1 (en) * | 1989-02-16 | 1990-08-23 | University Of Georgia Research Foundation, Inc. | Treatment of tibial dyschondroplasia |
| US5366736A (en) * | 1989-02-16 | 1994-11-22 | University Of Georgia Research Foundation, Inc. | Vitamin D derivative feed compositions and methods of use |
| US5316770A (en) * | 1989-02-16 | 1994-05-31 | University Of Georgia Research Foundation, Inc. | Vitamin D derivative feed compositions and methods of use |
| AU6247194A (en) * | 1993-02-19 | 1994-09-14 | Wisconsin Alumni Research Foundation | Use of 26,26,26,27,27,27-hexafluoro-1alpha,25-dihydroxycholecalcife rol for the treatment of calcium metabolism disorders |
| JP2009532458A (ja) * | 2006-04-06 | 2009-09-10 | ウイスコンシン アラムニ リサーチ ファンデーション | ２−メチレン−１α−ヒドロキシ−１９，２１−ジノルビタミンＤ３類縁体およびその使用 |
| NZ570712A (en) * | 2006-04-06 | 2011-11-25 | Wisconsin Alumni Res Found | 2-methylene-1alpha-hydroxy-18,19,21-trinorvitamin D3 analogs and uses thereof |
| AU2007291005A1 (en) * | 2006-04-06 | 2008-03-06 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D analogs with 1,2,or 3,2 heterocyclic ring |
| CA2639585A1 (en) * | 2006-04-06 | 2007-10-06 | Wisconsin Alumni Research Foundation | 2-methylene-1.alpha., 25-dihydroxy-18, 19, 21-trinorvitamin d3 and uses thereof |
| US8404666B2 (en) | 2006-04-06 | 2013-03-26 | Wisconsin Alumni Research Foundation | 2-substituted-1α,25-dihydroxy-19,26,27-trinor vitamin D analogs and uses thereof |
| MX2008012912A (es) * | 2006-04-06 | 2008-11-26 | Wisconsin Alumni Res Found | Analogos de 2-metilen-1a,25-dihidroxi-19,21-dinorvitamina d3 y sus usos. |
| NZ570816A (en) * | 2006-04-10 | 2011-07-29 | Wisconsin Alumni Res Found | 1alpha-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin D compounds with a 1,1-dimethylpropyl side chain |
| AU2010208323B2 (en) | 2009-01-27 | 2016-03-10 | Berg Llc | Vitamin D3 and analogs thereof for alleviating side effects associated with chemotherapy |
| EP2464357B1 (en) | 2009-08-14 | 2019-05-22 | Berg LLC | Vitamin d3 and analogs thereof for treating alopecia |
| SG10201709894RA (en) | 2013-05-29 | 2018-01-30 | Berg Llc | Preventing or mitigating chemotherapy induced alopecia using vitamin d |
| CN113968888B (zh) * | 2020-07-24 | 2023-06-27 | 上海医药工业研究院 | 一种胆甾衍生物的制备方法、其中间体及应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4183852A (en) * | 1977-07-18 | 1980-01-15 | Kaiser Emil T | Process for preparing 25-hydroxycholesterol |
| LU80545A1 (de) * | 1978-11-17 | 1980-06-05 | Hoffmann La Roche | Verfahren zur herstellung von 1a,3s-dihydroxy->5-steroiden |
| US4217279A (en) * | 1978-12-18 | 1980-08-12 | Kaiser Emil T | Synthesis of steroids |
| JPS5598199A (en) * | 1979-01-17 | 1980-07-25 | Eisai Co Ltd | Preparation of 25-hydroxy cholesta-1,4,6-trien-3-one |
| US4269777A (en) * | 1979-05-21 | 1981-05-26 | Wisconsin Alumni Research Foundation | Isotopically labeled vitamin D derivatives and processes for preparing same |
| IL60270A0 (en) * | 1979-06-14 | 1980-09-16 | Diamond Shamrock Corp | Preparation of 25-ydroxycholesterol |
| US4248791A (en) * | 1980-02-04 | 1981-02-03 | Wisconsin Alumni Research Foundation | 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol |
| US4360470A (en) * | 1980-10-22 | 1982-11-23 | Hoffmann-La Roche Inc. | Process and intermediates for the synthesis of Vitamin D3 metabolites and chenodeoxycholic acid |
| US4358406A (en) * | 1981-07-27 | 1982-11-09 | Wisconsin Alumni Research Foundation | 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same |
-
1982
- 1982-05-26 US US06/382,055 patent/US4411833A/en not_active Expired - Lifetime
-
1983
- 1983-04-18 WO PCT/US1983/000577 patent/WO1983004256A1/en not_active Ceased
- 1983-04-18 CH CH341/84A patent/CH663212A5/de not_active IP Right Cessation
- 1983-04-18 AU AU15542/83A patent/AU561182B2/en not_active Ceased
- 1983-04-18 DE DE19833390016 patent/DE3390016C2/de not_active Expired
- 1983-04-18 CH CH4413/86A patent/CH662572A5/de not_active IP Right Cessation
- 1983-04-18 NL NL8320153A patent/NL8320153A/nl not_active Application Discontinuation
- 1983-04-29 IL IL68537A patent/IL68537A/xx not_active IP Right Cessation
- 1983-05-24 IT IT21261/83A patent/IT1203706B/it active
- 1983-05-24 IE IE1226/83A patent/IE55022B1/en not_active IP Right Cessation
- 1983-05-25 FR FR8308650A patent/FR2527615B1/fr not_active Expired
- 1983-05-25 BE BE0/210839A patent/BE896830A/fr not_active IP Right Cessation
- 1983-05-26 GB GB08314612A patent/GB2121044B/en not_active Expired
- 1983-11-04 FR FR8317598A patent/FR2533929B1/fr not_active Expired
-
1984
- 1984-01-25 DK DK032684A patent/DK168539B1/da active IP Right Grant
- 1984-06-19 GB GB08415630A patent/GB2140016B/en not_active Expired
-
1992
- 1992-01-23 JP JP4032644A patent/JPH0742305B2/ja not_active Expired - Lifetime
- 1992-01-23 JP JP4032645A patent/JPH0742306B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IL68537A0 (en) | 1983-07-31 |
| GB2121044B (en) | 1986-01-02 |
| DK32684D0 (da) | 1984-01-25 |
| BE896830A (fr) | 1983-09-16 |
| GB2121044A (en) | 1983-12-14 |
| US4411833A (en) | 1983-10-25 |
| WO1983004256A1 (en) | 1983-12-08 |
| FR2533929B1 (fr) | 1986-10-31 |
| FR2527615B1 (fr) | 1986-05-23 |
| IL68537A (en) | 1986-07-31 |
| IT1203706B (it) | 1989-02-15 |
| IE55022B1 (en) | 1990-04-25 |
| AU1554283A (en) | 1983-12-16 |
| NL8320153A (nl) | 1984-04-02 |
| JPH0742305B2 (ja) | 1995-05-10 |
| DE3390016C2 (de) | 1989-08-10 |
| IT8321261A0 (it) | 1983-05-24 |
| DE3390016T1 (de) | 1984-05-17 |
| AU561182B2 (en) | 1987-04-30 |
| JPH0742306B2 (ja) | 1995-05-10 |
| CH663212A5 (de) | 1987-11-30 |
| GB8314612D0 (en) | 1983-06-29 |
| GB2140016A (en) | 1984-11-21 |
| IE831226L (en) | 1983-11-26 |
| JPH0578388A (ja) | 1993-03-30 |
| CH662572A5 (de) | 1987-10-15 |
| GB8415630D0 (en) | 1984-07-25 |
| DK168539B1 (da) | 1994-04-18 |
| JPH0578387A (ja) | 1993-03-30 |
| FR2533929A1 (fr) | 1984-04-06 |
| GB2140016B (en) | 1986-01-02 |
| FR2527615A1 (fr) | 1983-12-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) |