FR2533929B1 - Ester methylique de l'acide 25, 26, 27 -trinor-1a, 2b-epoxy-cholesta-4,6-diene-3-one-24-oique - Google Patents

Ester methylique de l'acide 25, 26, 27 -trinor-1a, 2b-epoxy-cholesta-4,6-diene-3-one-24-oique

Info

Publication number
FR2533929B1
FR2533929B1 FR8317598A FR8317598A FR2533929B1 FR 2533929 B1 FR2533929 B1 FR 2533929B1 FR 8317598 A FR8317598 A FR 8317598A FR 8317598 A FR8317598 A FR 8317598A FR 2533929 B1 FR2533929 B1 FR 2533929B1
Authority
FR
France
Prior art keywords
oique
cholesta
trinor
diene
epoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8317598A
Other languages
English (en)
Other versions
FR2533929A1 (fr
Inventor
Hector F Deluca
Yoko Tanaka
Nobuo Ikekawa
Yoshiro Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of FR2533929A1 publication Critical patent/FR2533929A1/fr
Application granted granted Critical
Publication of FR2533929B1 publication Critical patent/FR2533929B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8317598A 1982-05-26 1983-11-04 Ester methylique de l'acide 25, 26, 27 -trinor-1a, 2b-epoxy-cholesta-4,6-diene-3-one-24-oique Expired FR2533929B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/382,055 US4411833A (en) 1982-05-26 1982-05-26 Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol

Publications (2)

Publication Number Publication Date
FR2533929A1 FR2533929A1 (fr) 1984-04-06
FR2533929B1 true FR2533929B1 (fr) 1986-10-31

Family

ID=23507359

Family Applications (2)

Application Number Title Priority Date Filing Date
FR8308650A Expired FR2527615B1 (fr) 1982-05-26 1983-05-25 Procede de preparation du 26,26,26,27,27,27-hexafluoro-1a,25-dihydroxycholesterol
FR8317598A Expired FR2533929B1 (fr) 1982-05-26 1983-11-04 Ester methylique de l'acide 25, 26, 27 -trinor-1a, 2b-epoxy-cholesta-4,6-diene-3-one-24-oique

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR8308650A Expired FR2527615B1 (fr) 1982-05-26 1983-05-25 Procede de preparation du 26,26,26,27,27,27-hexafluoro-1a,25-dihydroxycholesterol

Country Status (14)

Country Link
US (1) US4411833A (fr)
JP (2) JPH0742305B2 (fr)
AU (1) AU561182B2 (fr)
BE (1) BE896830A (fr)
CH (2) CH663212A5 (fr)
DE (1) DE3390016C2 (fr)
DK (1) DK168539B1 (fr)
FR (2) FR2527615B1 (fr)
GB (2) GB2121044B (fr)
IE (1) IE55022B1 (fr)
IL (1) IL68537A (fr)
IT (1) IT1203706B (fr)
NL (1) NL8320153A (fr)
WO (1) WO1983004256A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4613594A (en) * 1984-11-16 1986-09-23 Hoffmann-La Roche Inc. Fluorinated vitamin D3 compounds
US4749710A (en) * 1985-05-01 1988-06-07 Hoffmann-La Roche Inc. Immunosuppressive agents
US4619920A (en) * 1985-09-16 1986-10-28 Wisconsin Alumni Research Foundation 26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D3
JPH0764804B2 (ja) * 1986-04-25 1995-07-12 住友製薬株式会社 活性型ビタミンｄ３のフッ素誘導体
US5366736A (en) * 1989-02-16 1994-11-22 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
WO1990009179A1 (fr) * 1989-02-16 1990-08-23 University Of Georgia Research Foundation, Inc. Traitement de la dyschondroplasie tibiale d'allien
US5316770A (en) * 1989-02-16 1994-05-31 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
US5571802A (en) * 1993-02-19 1996-11-05 Wisconsin Alumni Research Foundation Method of treating post menopausal osteoporosis with hexafluro-vitamin D
US7648972B2 (en) * 2006-04-06 2010-01-19 Wisconsin Alumni Research Foundation 2-methylene-1α-hydroxy-19,21-dinorvitamin D3 analogs and uses thereof
JP2009532457A (ja) * 2006-04-06 2009-09-10 ウイスコンシン アラムニ リサーチ ファンデーション ２−メチレン−１α−ヒドロキシ−１８，１９，２１−トリノルビタミンＤ３類縁体およびその使用
AU2007298673A1 (en) 2006-04-06 2008-03-27 Wisconsin Alumni Research Foundation 2- substituted-1alpha, 25-dihydroxy-19,26,27-trinor vitamin D analogs and uses thereof
CA2639585A1 (fr) * 2006-04-06 2007-10-06 Wisconsin Alumni Research Foundation 2-methylene-1.alpha.-25-dihydroxy-18,19,21-trinor-vitamine d3 et utilisations connexes
WO2007118198A2 (fr) * 2006-04-06 2007-10-18 Wisconsin Alumni Research Foundation ANALOGUES DE LA 2-MÉTHYLÈNE-1α,25-DIHYDROXY-19,21-DINOR-VITAMINE D3 ET LEURS UTILISATIONS
NZ570815A (en) * 2006-04-06 2012-01-12 Wisconsin Alumni Res Found 19-nor-vitamin D analogs with 1,2,or 3,2 heterocyclic ring
AU2007287263A1 (en) * 2006-04-10 2008-02-28 Wisconsin Alumni Research Foundation Lalpha-hydroxy-2- (3 ' -hydroxypropylidene) -19-nor- vitamin D compounds with a 1,1-dimethylpropyl side chain
EP2393494A1 (fr) 2009-01-27 2011-12-14 Berg Biosystems, LLC Vitamines d3 et analogues de celles-ci pour soulagement des effets secondaires associés à une chimiothérapie
CA2770683C (fr) 2009-08-14 2018-09-04 Berg Biosystems, Llc Vitamine d3 et ses analogues pour le traitement de l'alopecie
SG10201709894RA (en) 2013-05-29 2018-01-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
CN113968888B (zh) * 2020-07-24 2023-06-27 上海医药工业研究院 一种胆甾衍生物的制备方法、其中间体及应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4183852A (en) * 1977-07-18 1980-01-15 Kaiser Emil T Process for preparing 25-hydroxycholesterol
LU80545A1 (de) * 1978-11-17 1980-06-05 Hoffmann La Roche Verfahren zur herstellung von 1a,3s-dihydroxy->5-steroiden
US4217279A (en) * 1978-12-18 1980-08-12 Kaiser Emil T Synthesis of steroids
JPS5598199A (en) * 1979-01-17 1980-07-25 Eisai Co Ltd Preparation of 25-hydroxy cholesta-1,4,6-trien-3-one
US4269777A (en) * 1979-05-21 1981-05-26 Wisconsin Alumni Research Foundation Isotopically labeled vitamin D derivatives and processes for preparing same
IL60270A0 (en) * 1979-06-14 1980-09-16 Diamond Shamrock Corp Preparation of 25-ydroxycholesterol
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol
US4360470A (en) * 1980-10-22 1982-11-23 Hoffmann-La Roche Inc. Process and intermediates for the synthesis of Vitamin D3 metabolites and chenodeoxycholic acid
US4358406A (en) * 1981-07-27 1982-11-09 Wisconsin Alumni Research Foundation 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same

Also Published As

Publication number Publication date
IL68537A0 (en) 1983-07-31
FR2533929A1 (fr) 1984-04-06
JPH0578388A (ja) 1993-03-30
IL68537A (en) 1986-07-31
FR2527615B1 (fr) 1986-05-23
GB2121044B (en) 1986-01-02
GB2140016A (en) 1984-11-21
IT1203706B (it) 1989-02-15
CH662572A5 (de) 1987-10-15
GB2121044A (en) 1983-12-14
DK32684A (da) 1984-01-25
IT8321261A0 (it) 1983-05-24
IE831226L (en) 1983-11-26
WO1983004256A1 (fr) 1983-12-08
CH663212A5 (de) 1987-11-30
DE3390016C2 (de) 1989-08-10
DK32684D0 (da) 1984-01-25
JPH0742305B2 (ja) 1995-05-10
GB2140016B (en) 1986-01-02
JPH0742306B2 (ja) 1995-05-10
DK168539B1 (da) 1994-04-18
BE896830A (fr) 1983-09-16
DE3390016T1 (de) 1984-05-17
GB8415630D0 (en) 1984-07-25
AU561182B2 (en) 1987-04-30
GB8314612D0 (en) 1983-06-29
JPH0578387A (ja) 1993-03-30
IE55022B1 (en) 1990-04-25
US4411833A (en) 1983-10-25
FR2527615A1 (fr) 1983-12-02
NL8320153A (nl) 1984-04-02
AU1554283A (en) 1983-12-16

Similar Documents

Publication Publication Date Title
FR2470107B1 (fr) Procede de preparation d'acide acrylique
RO86355A (fr) Procede pour la preparation de(s)-epymere de l'ester de l'acide-7-beta-malonamido-4-alpha-metho0y-3-tetrazolylthiomethyl-1-dethia-1-o0a-3-cephem-4-carbo0ylique
FR2533929B1 (fr) Ester methylique de l'acide 25, 26, 27 -trinor-1a, 2b-epoxy-cholesta-4,6-diene-3-one-24-oique
FR2554809B1 (fr) Procede de preparation de l'acide acrylique
MC1512A1 (fr) Nouveaux derives d'acide phenoxyalkylcarboxylique
BE890223A (fr) Procede de preparation de derives de l'acide quinoleine-carboxylique
PT69815A (fr) Procede de preparation de l' o-methallyloxyphenol
BE886370A (fr) Derives de l'acide 16-hydroxy-prostanoique 4,5-insatures
MA18782A1 (fr) Purification de l'acide phosphorique .
BE891632A (fr) Procede de preparation d'esters monoalkyliques optiquement actifs de l'acide ???-(s)-aminoglutarique
RO82537A (fr) Procede pour la preparation de l'acide diaceton-cetogluconique
BE870703A (fr) Rpocede de preparation d'acide cyanurique
BE886392A (fr) Procede de preparation de l'acide trimellitique
FR2535322B1 (fr) Preparation d'acides aminocyclopentaniques
BE896868A (fr) Procede de preparation d'acide acetique.
FR2546889B1 (fr) Procede de preparation d'un acide aminolactonecarboxylique
DE3361290D1 (de) Preparation of cyanobenzoic-acid esters
BE889169A (fr) Procede de preparation d'acide 2-methoxy-3-6-dichloro-benzoique
FR2542758B1 (fr) Procede de preparation de l'acide l-glutamique
BE879262A (fr) Procede de preparation de l'acide di-n-propylacetique
FR2495138B1 (fr) Procede de preparation de l'acide gloxylique
FR2541279B1 (fr) Derives de l'acide 1-aza-7-oxo-bicyclo(3.2.0)-hept-2-ene-2-carboxylique
BE856559A (fr) Procede de preparation d'acide isobutyrique
FR2543948B1 (fr) Procede de preparation de l'acide 1-naphtol-4-sulfonique
FR2518539B1 (fr) Procede de preparation d'esters de l'acide nitroacetique