IT1203706B - Metodo per la preparazione di 26,26,26,27,27,27-esafluoro-1-alfa,25-diidrossicolesterolo - Google Patents

Metodo per la preparazione di 26,26,26,27,27,27-esafluoro-1-alfa,25-diidrossicolesterolo

Info

Publication number
IT1203706B
IT1203706B IT21261/83A IT2126183A IT1203706B IT 1203706 B IT1203706 B IT 1203706B IT 21261/83 A IT21261/83 A IT 21261/83A IT 2126183 A IT2126183 A IT 2126183A IT 1203706 B IT1203706 B IT 1203706B
Authority
IT
Italy
Prior art keywords
dihydroxicolesterol
hexafluoro
alpha
preparation
Prior art date
Application number
IT21261/83A
Other languages
English (en)
Other versions
IT8321261A0 (it
Inventor
Hector F Deluca
Yoko Tanaka
Ikerawa Nobuo
Kobayashi Yoshiro
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of IT8321261A0 publication Critical patent/IT8321261A0/it
Application granted granted Critical
Publication of IT1203706B publication Critical patent/IT1203706B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nutrition Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT21261/83A 1982-05-26 1983-05-24 Metodo per la preparazione di 26,26,26,27,27,27-esafluoro-1-alfa,25-diidrossicolesterolo IT1203706B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/382,055 US4411833A (en) 1982-05-26 1982-05-26 Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol

Publications (2)

Publication Number Publication Date
IT8321261A0 IT8321261A0 (it) 1983-05-24
IT1203706B true IT1203706B (it) 1989-02-15

Family

ID=23507359

Family Applications (1)

Application Number Title Priority Date Filing Date
IT21261/83A IT1203706B (it) 1982-05-26 1983-05-24 Metodo per la preparazione di 26,26,26,27,27,27-esafluoro-1-alfa,25-diidrossicolesterolo

Country Status (14)

Country Link
US (1) US4411833A (it)
JP (2) JPH0742305B2 (it)
AU (1) AU561182B2 (it)
BE (1) BE896830A (it)
CH (2) CH663212A5 (it)
DE (1) DE3390016C2 (it)
DK (1) DK168539B1 (it)
FR (2) FR2527615B1 (it)
GB (2) GB2121044B (it)
IE (1) IE55022B1 (it)
IL (1) IL68537A (it)
IT (1) IT1203706B (it)
NL (1) NL8320153A (it)
WO (1) WO1983004256A1 (it)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4613594A (en) * 1984-11-16 1986-09-23 Hoffmann-La Roche Inc. Fluorinated vitamin D3 compounds
US4749710A (en) * 1985-05-01 1988-06-07 Hoffmann-La Roche Inc. Immunosuppressive agents
US4619920A (en) * 1985-09-16 1986-10-28 Wisconsin Alumni Research Foundation 26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D3
JPH0764804B2 (ja) * 1986-04-25 1995-07-12 住友製薬株式会社 活性型ビタミンｄ３のフッ素誘導体
US5316770A (en) * 1989-02-16 1994-05-31 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
US5366736A (en) * 1989-02-16 1994-11-22 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
WO1990009179A1 (en) * 1989-02-16 1990-08-23 University Of Georgia Research Foundation, Inc. Treatment of tibial dyschondroplasia
US5571802A (en) * 1993-02-19 1996-11-05 Wisconsin Alumni Research Foundation Method of treating post menopausal osteoporosis with hexafluro-vitamin D
WO2008026078A2 (en) * 2006-04-06 2008-03-06 Wisconsin Alumni Research Foundation 19-nor-vitamin d analogs with 1,2,or 3,2 heterocyclic ring
JP2009533483A (ja) * 2006-04-06 2009-09-17 ウイスコンシン アラムニ リサーチ ファンデーション ２−メチレン−１α，２５−ジヒドロキシ−１８，１９，２１−トリノルビタミンＤ３およびその使用
MX2008012672A (es) * 2006-04-06 2008-10-15 Wisconsin Alumni Res Found Analogos de 2-metilen-1a-hidroxi-18,19,21-trinor vitamina d3 y sus usos.
MX2008012671A (es) 2006-04-06 2008-10-15 Wisconsin Alumni Res Found Analogos 1 a,25-dihidroxi- 19, 26,27-trinor vitamina d 2-sustituidos y sus usos.
EP2046737B1 (en) * 2006-04-06 2011-09-07 Wisconsin Alumni Research Foundation 2-methylene-1 alpha,25-dihydroxy-19,21-dinorvitamin d3 analogs and uses thereof
MX2008012673A (es) * 2006-04-06 2008-10-15 Wisconsin Alumni Res Found Analogos de 2-metilen-1a-hidroxi-19, 21-dinorvitamina d3 y sus usos.
US7763598B2 (en) * 2006-04-10 2010-07-27 Wisconsin Alumni Research Foundation 1α-hydroxy-2-(3′-hydroxypropylidene)-19-nor-vitamin D compounds with a 1,1-dimethylpropyl side chain
SG2014006324A (en) 2009-01-27 2014-03-28 Berg Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
CN102655869B (zh) 2009-08-14 2016-08-10 博格有限责任公司 用于治疗脱发的维生素d3及其类似物
HK1222819A1 (zh) 2013-05-29 2017-07-14 博格有限责任公司 使用维生素d预防或减轻化疗诱发的脱发
CN113968888B (zh) * 2020-07-24 2023-06-27 上海医药工业研究院 一种胆甾衍生物的制备方法、其中间体及应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4183852A (en) * 1977-07-18 1980-01-15 Kaiser Emil T Process for preparing 25-hydroxycholesterol
LU80545A1 (de) * 1978-11-17 1980-06-05 Hoffmann La Roche Verfahren zur herstellung von 1a,3s-dihydroxy->5-steroiden
US4217279A (en) * 1978-12-18 1980-08-12 Kaiser Emil T Synthesis of steroids
JPS5598199A (en) * 1979-01-17 1980-07-25 Eisai Co Ltd Preparation of 25-hydroxy cholesta-1,4,6-trien-3-one
US4269777A (en) * 1979-05-21 1981-05-26 Wisconsin Alumni Research Foundation Isotopically labeled vitamin D derivatives and processes for preparing same
IL60270A0 (en) * 1979-06-14 1980-09-16 Diamond Shamrock Corp Preparation of 25-ydroxycholesterol
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol
US4360470A (en) * 1980-10-22 1982-11-23 Hoffmann-La Roche Inc. Process and intermediates for the synthesis of Vitamin D3 metabolites and chenodeoxycholic acid
US4358406A (en) * 1981-07-27 1982-11-09 Wisconsin Alumni Research Foundation 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same

Also Published As

Publication number Publication date
IE55022B1 (en) 1990-04-25
WO1983004256A1 (en) 1983-12-08
FR2533929B1 (fr) 1986-10-31
BE896830A (fr) 1983-09-16
JPH0742306B2 (ja) 1995-05-10
CH662572A5 (de) 1987-10-15
IL68537A (en) 1986-07-31
IT8321261A0 (it) 1983-05-24
US4411833A (en) 1983-10-25
DE3390016T1 (de) 1984-05-17
AU1554283A (en) 1983-12-16
CH663212A5 (de) 1987-11-30
FR2527615A1 (fr) 1983-12-02
JPH0742305B2 (ja) 1995-05-10
FR2533929A1 (fr) 1984-04-06
GB2140016A (en) 1984-11-21
DE3390016C2 (de) 1989-08-10
FR2527615B1 (fr) 1986-05-23
GB2121044A (en) 1983-12-14
JPH0578387A (ja) 1993-03-30
IE831226L (en) 1983-11-26
GB2140016B (en) 1986-01-02
JPH0578388A (ja) 1993-03-30
DK168539B1 (da) 1994-04-18
DK32684D0 (da) 1984-01-25
GB2121044B (en) 1986-01-02
DK32684A (da) 1984-01-25
GB8415630D0 (en) 1984-07-25
AU561182B2 (en) 1987-04-30
GB8314612D0 (en) 1983-06-29
IL68537A0 (en) 1983-07-31
NL8320153A (nl) 1984-04-02

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Effective date: 19970530