BE896830A - Procede de preparation du 26, 26, 26, 27, 27, 27-hexafluoro-1 alpha, 25-dihydroxycholesterol. - Google Patents

Procede de preparation du 26, 26, 26, 27, 27, 27-hexafluoro-1 alpha, 25-dihydroxycholesterol.

Info

Publication number
BE896830A
BE896830A BE0/210839A BE210839A BE896830A BE 896830 A BE896830 A BE 896830A BE 0/210839 A BE0/210839 A BE 0/210839A BE 210839 A BE210839 A BE 210839A BE 896830 A BE896830 A BE 896830A
Authority
BE
Belgium
Prior art keywords
dihydroxycholesterol
hexafluoro
alpha
preparation
Prior art date
Application number
BE0/210839A
Other languages
English (en)
Inventor
H F Deluca
Y Tanaka
N Ikekawa
Y Kobayashi
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of BE896830A publication Critical patent/BE896830A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nutrition Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BE0/210839A 1982-05-26 1983-05-25 Procede de preparation du 26, 26, 26, 27, 27, 27-hexafluoro-1 alpha, 25-dihydroxycholesterol. BE896830A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/382,055 US4411833A (en) 1982-05-26 1982-05-26 Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol

Publications (1)

Publication Number Publication Date
BE896830A true BE896830A (fr) 1983-09-16

Family

ID=23507359

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/210839A BE896830A (fr) 1982-05-26 1983-05-25 Procede de preparation du 26, 26, 26, 27, 27, 27-hexafluoro-1 alpha, 25-dihydroxycholesterol.

Country Status (14)

Country Link
US (1) US4411833A (fr)
JP (2) JPH0742305B2 (fr)
AU (1) AU561182B2 (fr)
BE (1) BE896830A (fr)
CH (2) CH663212A5 (fr)
DE (1) DE3390016C2 (fr)
DK (1) DK168539B1 (fr)
FR (2) FR2527615B1 (fr)
GB (2) GB2121044B (fr)
IE (1) IE55022B1 (fr)
IL (1) IL68537A (fr)
IT (1) IT1203706B (fr)
NL (1) NL8320153A (fr)
WO (1) WO1983004256A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4613594A (en) * 1984-11-16 1986-09-23 Hoffmann-La Roche Inc. Fluorinated vitamin D3 compounds
US4749710A (en) * 1985-05-01 1988-06-07 Hoffmann-La Roche Inc. Immunosuppressive agents
US4619920A (en) * 1985-09-16 1986-10-28 Wisconsin Alumni Research Foundation 26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D3
JPH0764804B2 (ja) * 1986-04-25 1995-07-12 住友製薬株式会社 活性型ビタミンｄ３のフッ素誘導体
US5316770A (en) * 1989-02-16 1994-05-31 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
WO1990009179A1 (fr) * 1989-02-16 1990-08-23 University Of Georgia Research Foundation, Inc. Traitement de la dyschondroplasie tibiale d'allien
US5366736A (en) * 1989-02-16 1994-11-22 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
AU6247194A (en) * 1993-02-19 1994-09-14 Wisconsin Alumni Research Foundation Use of 26,26,26,27,27,27-hexafluoro-1alpha,25-dihydroxycholecalcife rol for the treatment of calcium metabolism disorders
AU2007291005A1 (en) * 2006-04-06 2008-03-06 Wisconsin Alumni Research Foundation 19-nor-vitamin D analogs with 1,2,or 3,2 heterocyclic ring
AU2007234717B2 (en) * 2006-04-06 2012-04-19 Wisconsin Alumni Research Foundation 2-methylene-1alpha,25-dihydroxy-19,21-dinorvitamin D3 analogs and uses thereof
MX2008012913A (es) * 2006-04-06 2009-03-06 Wisconsin Alumni Res Found 2-metilen-1a,25-dihidroxi-18,19,21-trinorvitamina d3 y sus usos.
EP2021320A2 (fr) 2006-04-06 2009-02-11 Wisconsin Alumni Research Foundation Analogues de la 1alpha, 25-dihydroxy-19,26,27-trinor vitamine d substituée en position 2 et leurs utilisations
MX2008012673A (es) * 2006-04-06 2008-10-15 Wisconsin Alumni Res Found Analogos de 2-metilen-1a-hidroxi-19, 21-dinorvitamina d3 y sus usos.
US8575136B2 (en) * 2006-04-06 2013-11-05 Wisconsin Alumni Research Foundation 2-methylene-1α-hydroxy-18,19,21-trinorvitamin D3 analogs and uses thereof
ATE496885T1 (de) * 2006-04-10 2011-02-15 Wisconsin Alumni Res Found 1-alpha-hydroxy-2-(3'-hydroxypropyliden)-19-nor vitamin-d-verbindungen mit einer 1,1- dimethylpropyl-seitenkette
SG173119A1 (en) 2009-01-27 2011-08-29 Berg Biosystems Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
MX366076B (es) 2009-08-14 2019-06-27 Berg Llc Vitamina d3 y analogos de la misma para tratar alopecia.
SG10201709894RA (en) 2013-05-29 2018-01-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
CN113968888B (zh) * 2020-07-24 2023-06-27 上海医药工业研究院 一种胆甾衍生物的制备方法、其中间体及应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4183852A (en) * 1977-07-18 1980-01-15 Kaiser Emil T Process for preparing 25-hydroxycholesterol
LU80545A1 (de) * 1978-11-17 1980-06-05 Hoffmann La Roche Verfahren zur herstellung von 1a,3s-dihydroxy->5-steroiden
US4217279A (en) * 1978-12-18 1980-08-12 Kaiser Emil T Synthesis of steroids
JPS5598199A (en) * 1979-01-17 1980-07-25 Eisai Co Ltd Preparation of 25-hydroxy cholesta-1,4,6-trien-3-one
US4269777A (en) * 1979-05-21 1981-05-26 Wisconsin Alumni Research Foundation Isotopically labeled vitamin D derivatives and processes for preparing same
IL60270A0 (en) * 1979-06-14 1980-09-16 Diamond Shamrock Corp Preparation of 25-ydroxycholesterol
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol
US4360470A (en) * 1980-10-22 1982-11-23 Hoffmann-La Roche Inc. Process and intermediates for the synthesis of Vitamin D3 metabolites and chenodeoxycholic acid
US4358406A (en) * 1981-07-27 1982-11-09 Wisconsin Alumni Research Foundation 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same

Also Published As

Publication number Publication date
IT1203706B (it) 1989-02-15
WO1983004256A1 (fr) 1983-12-08
JPH0742305B2 (ja) 1995-05-10
JPH0742306B2 (ja) 1995-05-10
NL8320153A (nl) 1984-04-02
FR2533929B1 (fr) 1986-10-31
DK32684D0 (da) 1984-01-25
IT8321261A0 (it) 1983-05-24
CH663212A5 (de) 1987-11-30
JPH0578387A (ja) 1993-03-30
AU561182B2 (en) 1987-04-30
GB2140016B (en) 1986-01-02
GB2121044B (en) 1986-01-02
CH662572A5 (de) 1987-10-15
FR2527615A1 (fr) 1983-12-02
GB2140016A (en) 1984-11-21
FR2533929A1 (fr) 1984-04-06
IE55022B1 (en) 1990-04-25
DE3390016T1 (de) 1984-05-17
FR2527615B1 (fr) 1986-05-23
IE831226L (en) 1983-11-26
GB2121044A (en) 1983-12-14
AU1554283A (en) 1983-12-16
DE3390016C2 (de) 1989-08-10
DK168539B1 (da) 1994-04-18
IL68537A (en) 1986-07-31
US4411833A (en) 1983-10-25
GB8314612D0 (en) 1983-06-29
DK32684A (da) 1984-01-25
JPH0578388A (ja) 1993-03-30
IL68537A0 (en) 1983-07-31
GB8415630D0 (en) 1984-07-25

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: WISCONSIN ALUMNI RESEARCH FOUNDATION

Effective date: 20010531