DK149095C - Fremgangsmaade til fremstilling af en cholesterolsynteseinhiberende forbindelse kaldet monacolin k - Google Patents
Fremgangsmaade til fremstilling af en cholesterolsynteseinhiberende forbindelse kaldet monacolin kInfo
- Publication number
- DK149095C DK149095C DK73080A DK73080A DK149095C DK 149095 C DK149095 C DK 149095C DK 73080 A DK73080 A DK 73080A DK 73080 A DK73080 A DK 73080A DK 149095 C DK149095 C DK 149095C
- Authority
- DK
- Denmark
- Prior art keywords
- preparing
- procedure
- cholesterol synthesis
- compound called
- inhibitive compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK47085A DK165990C (da) | 1979-02-20 | 1985-02-01 | Fremgangsmaade til fremstilling af carboxylsyren af en cholesterolsynteseinhiberende forbindelse kaldet monacolin k eller salte deraf |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1785679 | 1979-02-20 | ||
| JP54017856A JPS5925599B2 (ja) | 1979-02-20 | 1979-02-20 | 新生理活性物質モナコリンｋおよびその製造法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK73080A DK73080A (da) | 1980-08-21 |
| DK149095B DK149095B (da) | 1986-01-20 |
| DK149095C true DK149095C (da) | 1986-06-16 |
Family
ID=11955290
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK73080A DK149095C (da) | 1979-02-20 | 1980-02-20 | Fremgangsmaade til fremstilling af en cholesterolsynteseinhiberende forbindelse kaldet monacolin k |
| DK021889A DK21889D0 (da) | 1979-02-20 | 1989-01-18 | Anvendelse af monacolin k, den tilsvarende carboxylsyreforbindelse eller salte af carboxylsyren til fremstilling af et laegemiddel til behandling af hypercholesterolaemi |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK021889A DK21889D0 (da) | 1979-02-20 | 1989-01-18 | Anvendelse af monacolin k, den tilsvarende carboxylsyreforbindelse eller salte af carboxylsyren til fremstilling af et laegemiddel til behandling af hypercholesterolaemi |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPS5925599B2 (da) |
| KR (1) | KR830002801B1 (da) |
| AT (1) | AT373915B (da) |
| AU (1) | AU532626B2 (da) |
| BE (1) | BE881825A (da) |
| CA (1) | CA1129794A (da) |
| CH (1) | CH645890A5 (da) |
| DD (1) | DD154494A5 (da) |
| DE (2) | DE3006216C2 (da) |
| DK (2) | DK149095C (da) |
| ES (1) | ES488796A0 (da) |
| FI (1) | FI66427C (da) |
| FR (1) | FR2449685B1 (da) |
| GB (1) | GB2046737B (da) |
| HU (1) | HU182069B (da) |
| IE (1) | IE49743B1 (da) |
| IT (1) | IT1175260B (da) |
| MX (1) | MX6314E (da) |
| NL (1) | NL191540C (da) |
| NO (1) | NO153974C (da) |
| NZ (1) | NZ192919A (da) |
| PH (1) | PH15145A (da) |
| PL (1) | PL124304B1 (da) |
| SE (1) | SE453301B (da) |
| SG (1) | SG6784G (da) |
| SU (2) | SU1158048A3 (da) |
| ZA (1) | ZA80962B (da) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55150898A (en) * | 1979-05-11 | 1980-11-25 | Sankyo Co Ltd | Preparation of a new physiologically active substance mb-530b |
| US4231938A (en) * | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| JPS5621594A (en) * | 1979-07-27 | 1981-02-28 | Sankyo Co Ltd | Mb-530b carboxylic acid metal salt and its preparation |
| PT72394B (en) * | 1980-02-04 | 1982-09-06 | Merck & Co Inc | Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics |
| AU548996B2 (en) * | 1980-02-04 | 1986-01-09 | Merck & Co., Inc. | Tetrahydro-2h-pyran-2-one derivatives |
| JPH0692381B2 (ja) * | 1980-03-31 | 1994-11-16 | 三共株式会社 | Ｍｂ−５３０ａ誘導体 |
| JPS56142236A (en) | 1980-04-08 | 1981-11-06 | Sankyo Co Ltd | Ml-236a and mb-530a derivative |
| DK149080C (da) * | 1980-06-06 | 1986-07-28 | Sankyo Co | Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre |
| JPS5835144A (ja) * | 1981-08-27 | 1983-03-01 | Sankyo Co Ltd | Ｍｂ−５３０ｂ誘導体およびその製造法 |
| US4782084A (en) * | 1987-06-29 | 1988-11-01 | Merck & Co., Inc. | HMG-COA reductase inhibitors |
| US4997848A (en) * | 1987-10-27 | 1991-03-05 | Sankyo Company, Limited | Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition |
| CA2062023A1 (en) | 1992-02-10 | 1993-08-11 | Jagroop S. Dahiya | Novel fungal strains and use thereof in antibiotic production |
| EP0629184A1 (en) * | 1992-03-04 | 1994-12-21 | Fujisawa Pharmaceutical Co., Ltd. | TETRALIN DERIVATIVES AS HMG-CoA REDUCTASE INHIBITORS |
| ZA933359B (en) | 1992-05-15 | 1993-12-08 | Sankyo Co | Octahydronaphthalene oxime derivatives for cholesterol biosynthesis inhibition, their preparation and use |
| US6812007B1 (en) * | 1992-11-04 | 2004-11-02 | Keri Vilmos | Process for the isolation and purification of mevinolin |
| HU210867B (en) * | 1992-11-04 | 1995-10-30 | Biogal Gyogyszergyar | Method for extraction and purification of mevinolin from culture medium |
| SI9300303A (en) * | 1993-06-08 | 1994-12-31 | Krka Tovarna Zdravil | Process for isolation of hypolipemic effective substance |
| US5409820A (en) * | 1993-08-06 | 1995-04-25 | Apotex, Inc. | Process for the production of lovastatin using Coniothyrium fuckelii |
| US6046022A (en) | 1996-09-30 | 2000-04-04 | Peking University | Methods and compositions employing red rice fermentation products |
| US7238348B2 (en) | 1996-09-30 | 2007-07-03 | Beijing Peking University Wbl Corporation Ltd. | Method of treatment of osteoporosis with compositions of red rice fermentation products |
| CZ300153B6 (cs) | 1998-03-20 | 2009-02-25 | Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Metabolicky kontrolovaný proces fermentace pri výrobe lovastatinové hydroxykyseliny |
| AU3654301A (en) | 2000-02-24 | 2001-09-03 | Biogal Gyogyszergyar | Method of purifying a fermentation broth |
| JP2003525935A (ja) | 2000-03-03 | 2003-09-02 | ビオガル ジョジセルジャール アール テー． | 低下したレベルの二量体不純物を伴うロバスタチン及びシンバスタチンの精製方法 |
| KR20010095780A (ko) * | 2000-04-12 | 2001-11-07 | 나가오카 마사시 | 배아 홍국 |
| IN192861B (da) | 2000-06-30 | 2004-05-22 | Ranbaxy Lab Ltd | |
| AU2002235885A1 (en) | 2001-02-09 | 2002-08-28 | Unilever N.V. | Process for the preparation of one or more statins by fermentation |
| KR100379075B1 (en) | 2002-03-07 | 2003-04-08 | Jinis Biopharmaceuticals Co | Method for producing low cholesterol animal food product and food product therefrom |
| KR20020093147A (ko) * | 2002-05-30 | 2002-12-13 | 지니스생명공학 주식회사 | 성인병 예방 및 치료 보조제 |
| KR100710500B1 (ko) | 2005-05-18 | 2007-04-24 | 고려대학교 산학협력단 | 홍국균을 이용한 모나콜린 ｋ 생산방법 |
| SI2373609T1 (sl) | 2008-12-19 | 2013-12-31 | Krka, D.D., Novo Mesto | Uporaba amfifilnih spojin za kontrolirano kristalizacijo statinov in intermediatov statinov |
| EP2327682A1 (en) | 2009-10-29 | 2011-06-01 | KRKA, D.D., Novo Mesto | Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates |
| RO128803A0 (ro) | 2012-10-12 | 2013-09-30 | Ion Gigel Fulga | Compoziţie pentru tratamentul sau prevenirea dislipidemiilor |
| CN110331151A (zh) * | 2019-04-11 | 2019-10-15 | 北京工商大学 | 紫色红曲菌mokH基因过表达菌株的构建方法 |
| CN111297938A (zh) * | 2020-03-11 | 2020-06-19 | 北京康立生医药技术开发有限公司 | 一种辅助降血脂组合物中洛伐他汀的检测方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5612114B2 (da) * | 1974-06-07 | 1981-03-18 | ||
| JPS55150898A (en) * | 1979-05-11 | 1980-11-25 | Sankyo Co Ltd | Preparation of a new physiologically active substance mb-530b |
| GR69216B (da) * | 1979-06-15 | 1982-05-07 | Merck & Co Inc |
-
1979
- 1979-02-20 JP JP54017856A patent/JPS5925599B2/ja not_active Expired
-
1980
- 1980-02-19 KR KR1019800000654A patent/KR830002801B1/ko active
- 1980-02-19 IE IE321/80A patent/IE49743B1/en not_active IP Right Cessation
- 1980-02-19 AU AU55673/80A patent/AU532626B2/en not_active Expired
- 1980-02-19 CA CA345,983A patent/CA1129794A/en not_active Expired
- 1980-02-20 DE DE3006216A patent/DE3006216C2/de not_active Expired
- 1980-02-20 SU SU802887300A patent/SU1158048A3/ru active
- 1980-02-20 NL NL8001041A patent/NL191540C/xx not_active IP Right Cessation
- 1980-02-20 ES ES488796A patent/ES488796A0/es active Granted
- 1980-02-20 HU HU80397A patent/HU182069B/hu unknown
- 1980-02-20 DK DK73080A patent/DK149095C/da not_active IP Right Cessation
- 1980-02-20 GB GB8005748A patent/GB2046737B/en not_active Expired
- 1980-02-20 IT IT67262/80A patent/IT1175260B/it active
- 1980-02-20 PL PL1980222120A patent/PL124304B1/pl unknown
- 1980-02-20 ZA ZA00800962A patent/ZA80962B/xx unknown
- 1980-02-20 AT AT0092980A patent/AT373915B/de not_active IP Right Cessation
- 1980-02-20 DD DD80219159A patent/DD154494A5/de unknown
- 1980-02-20 PH PH23668A patent/PH15145A/en unknown
- 1980-02-20 BE BE0/199476A patent/BE881825A/fr not_active IP Right Cessation
- 1980-02-20 NO NO800451A patent/NO153974C/no unknown
- 1980-02-20 NZ NZ192919A patent/NZ192919A/en unknown
- 1980-02-20 MX MX808652U patent/MX6314E/es unknown
- 1980-02-20 FI FI800506A patent/FI66427C/fi not_active IP Right Cessation
- 1980-02-20 FR FR8003662A patent/FR2449685B1/fr not_active Expired
- 1980-02-20 DE DE3051175A patent/DE3051175C2/de not_active Expired
- 1980-02-20 CH CH136680A patent/CH645890A5/de not_active IP Right Cessation
- 1980-02-20 SE SE8001339A patent/SE453301B/sv not_active IP Right Cessation
- 1980-09-12 SU SU802977031A patent/SU969702A1/ru active
-
1984
- 1984-01-24 SG SG67/84A patent/SG6784G/en unknown
-
1989
- 1989-01-18 DK DK021889A patent/DK21889D0/da not_active Application Discontinuation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUP | Patent expired |