CA3287278A1 - Nucleic acid based data storage - Google Patents
Nucleic acid based data storageInfo
- Publication number
- CA3287278A1 CA3287278A1 CA3287278A CA3287278A CA3287278A1 CA 3287278 A1 CA3287278 A1 CA 3287278A1 CA 3287278 A CA3287278 A CA 3287278A CA 3287278 A CA3287278 A CA 3287278A CA 3287278 A1 CA3287278 A1 CA 3287278A1
- Authority
- CA
- Canada
- Prior art keywords
- pat
- claimtext
- claimnumber
- oligonucleotides
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F21/00—Security arrangements for protecting computers, components thereof, programs or data against unauthorised activity
- G06F21/60—Protecting data
- G06F21/62—Protecting access to data via a platform, e.g. using keys or access control rules
- G06F21/6218—Protecting access to data via a platform, e.g. using keys or access control rules to a system of files or objects, e.g. local or distributed file system or database
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11C—STATIC STORES
- G11C11/00—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor
- G11C11/54—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using elements simulating biological cells, e.g. neuron
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11C—STATIC STORES
- G11C13/00—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00
- G11C13/0002—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00 using resistive RAM [RRAM] elements
- G11C13/0009—RRAM elements whose operation depends upon chemical change
- G11C13/0014—RRAM elements whose operation depends upon chemical change comprising cells based on organic memory material
- G11C13/0019—RRAM elements whose operation depends upon chemical change comprising cells based on organic memory material comprising bio-molecules
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
- G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
- G16B50/30—Data warehousing; Computing architectures
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
- G16B50/40—Encryption of genetic data
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H70/00—ICT specially adapted for the handling or processing of medical references
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
- H04L9/00—Cryptographic mechanisms or cryptographic arrangements for secret or secure communications; Network security protocols
- H04L9/32—Cryptographic mechanisms or cryptographic arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system or for message authentication, e.g. authorization, entity authentication, data integrity or data verification, non-repudiation, key authentication or verification of credentials
- H04L9/3226—Cryptographic mechanisms or cryptographic arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system or for message authentication, e.g. authorization, entity authentication, data integrity or data verification, non-repudiation, key authentication or verification of credentials using a predetermined code, e.g. password, passphrase or PIN
- H04L9/3231—Biological data, e.g. fingerprint, voice or retina
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Theoretical Computer Science (AREA)
- Bioethics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Databases & Information Systems (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Evolutionary Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Computer Security & Cryptography (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Computer Hardware Design (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Software Systems (AREA)
- General Physics & Mathematics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Signal Processing (AREA)
- Computer Networks & Wireless Communication (AREA)
- Biodiversity & Conservation Biology (AREA)
- Analytical Chemistry (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Primary Health Care (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762462284P | 2017-02-22 | 2017-02-22 | |
| US62/462,284 | 2017-02-22 | ||
| CA3054303A CA3054303C (en) | 2017-02-22 | 2018-02-22 | Nucleic acid based data storage |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3054303A Division CA3054303C (en) | 2017-02-22 | 2018-02-22 | Nucleic acid based data storage |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3287278A1 true CA3287278A1 (en) | 2026-03-02 |
Family
ID=63254091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3287278A Pending CA3287278A1 (en) | 2017-02-22 | 2018-02-22 | Nucleic acid based data storage |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11550939B2 (enExample) |
| EP (2) | EP4556433A3 (enExample) |
| JP (2) | JP2020508661A (enExample) |
| KR (2) | KR20240158370A (enExample) |
| CN (2) | CN118116478A (enExample) |
| CA (1) | CA3287278A1 (enExample) |
| SG (1) | SG11201907713WA (enExample) |
| WO (1) | WO2018156792A1 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102160389B1 (ko) | 2013-08-05 | 2020-09-28 | 트위스트 바이오사이언스 코포레이션 | 드 노보 합성된 유전자 라이브러리 |
| CA2975852A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
| WO2016172377A1 (en) | 2015-04-21 | 2016-10-27 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
| KR20180050411A (ko) | 2015-09-18 | 2018-05-14 | 트위스트 바이오사이언스 코포레이션 | 올리고핵산 변이체 라이브러리 및 그의 합성 |
| WO2017053450A1 (en) | 2015-09-22 | 2017-03-30 | Twist Bioscience Corporation | Flexible substrates for nucleic acid synthesis |
| EP3384077A4 (en) | 2015-12-01 | 2019-05-08 | Twist Bioscience Corporation | FUNCTIONALIZED SURFACES AND MANUFACTURE THEREOF |
| WO2018038772A1 (en) | 2016-08-22 | 2018-03-01 | Twist Bioscience Corporation | De novo synthesized nucleic acid libraries |
| WO2018039938A1 (zh) * | 2016-08-30 | 2018-03-08 | 清华大学 | 将数据进行生物存储并还原的方法 |
| EP4664304A3 (en) | 2016-09-21 | 2026-01-21 | Atlas Data Storage, Inc. | Nucleic acid based data storage |
| KR102521152B1 (ko) | 2016-11-16 | 2023-04-13 | 카탈로그 테크놀로지스, 인크. | 핵산-기반 데이터 저장용 시스템 |
| GB2573069A (en) | 2016-12-16 | 2019-10-23 | Twist Bioscience Corp | Variant libraries of the immunological synapse and synthesis thereof |
| WO2018156792A1 (en) | 2017-02-22 | 2018-08-30 | Twist Bioscience Corporation | Nucleic acid based data storage |
| CA3056388A1 (en) | 2017-03-15 | 2018-09-20 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
| IL271205B2 (en) | 2017-06-12 | 2025-02-01 | Twist Bioscience Corp | Methods for assembling continuous nucleic acids |
| WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| CN111566125A (zh) | 2017-09-11 | 2020-08-21 | 特韦斯特生物科学公司 | Gpcr结合蛋白及其合成 |
| CN111565834B (zh) | 2017-10-20 | 2022-08-26 | 特韦斯特生物科学公司 | 用于多核苷酸合成的加热的纳米孔 |
| EP3731959B1 (en) | 2017-12-29 | 2025-10-08 | Clear Labs, Inc. | Automated priming and library loading device |
| IL312616B2 (en) | 2018-01-04 | 2025-08-01 | Twist Bioscience Corp | Dna-based digital information storage |
| KR102998495B1 (ko) | 2018-03-16 | 2026-07-31 | 카탈로그 테크놀로지스, 인크. | 핵산-기반 데이터를 저장하기 위한 화학적 방법들 |
| WO2019196439A1 (en) * | 2018-04-13 | 2019-10-17 | The Hong Kong Polytechnic University | Data storage using peptides |
| US11302421B2 (en) * | 2018-04-13 | 2022-04-12 | The Hong Kong Polytechnic University | Data storage using peptides |
| US20200193301A1 (en) | 2018-05-16 | 2020-06-18 | Catalog Technologies, Inc. | Compositions and methods for nucleic acid-based data storage |
| EP3814497A4 (en) | 2018-05-18 | 2022-03-02 | Twist Bioscience Corporation | POLYNUCLEOTIDES, REAGENTS AND METHODS FOR NUCLEIC ACID HYBRIDIZATION |
| US11456759B2 (en) * | 2018-05-25 | 2022-09-27 | Erlich Lab Llc | Optimized encoding for storage of data on polymers in asynchronous synthesis |
| US12227776B2 (en) | 2018-06-13 | 2025-02-18 | Caribou Biosciences, Inc. | Engineered cascade components and cascade complexes |
| US10227576B1 (en) | 2018-06-13 | 2019-03-12 | Caribou Biosciences, Inc. | Engineered cascade components and cascade complexes |
| WO2020028912A2 (en) | 2018-08-03 | 2020-02-06 | Catolog Technologies, Inc | Systems and methods for storing and reading nucleic acid-based data with error protection |
| US11781169B2 (en) * | 2018-10-05 | 2023-10-10 | Microsoft Technology Licensing, Llc | Enzymatic DNA repair |
| EP3904527A4 (en) * | 2018-12-26 | 2022-08-10 | BGI Shenzhen | METHOD AND APPARATUS FOR FIXED-POINT EDITING OF A DATA-STORED NUCLEOTIDE SEQUENCE |
| EP3902816A4 (en) | 2018-12-26 | 2022-09-14 | Twist Bioscience Corporation | HIGH-PRECISION DE NOVO POLYNUCLEOTIDE SYNTHESIS |
| KR20210144698A (ko) | 2019-02-26 | 2021-11-30 | 트위스트 바이오사이언스 코포레이션 | 항체 최적화를 위한 변이 핵산 라이브러리 |
| CA3131689A1 (en) | 2019-02-26 | 2020-09-03 | Twist Bioscience Corporation | Variant nucleic acid libraries for glp1 receptor |
| KR20220017409A (ko) | 2019-05-09 | 2022-02-11 | 카탈로그 테크놀로지스, 인크. | Dna 기반 데이터 저장소에서 검색, 컴퓨팅 및 인덱싱하기 위한 데이터 구조 및 동작 |
| GB201907460D0 (en) | 2019-05-27 | 2019-07-10 | Vib Vzw | A method of storing information in pools of nucleic acid molecules |
| US10956806B2 (en) * | 2019-06-10 | 2021-03-23 | International Business Machines Corporation | Efficient assembly of oligonucleotides for nucleic acid based data storage |
| EP3987019A4 (en) | 2019-06-21 | 2023-04-19 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
| US11970696B1 (en) * | 2019-08-27 | 2024-04-30 | Leidos, Inc. | Optical methods and systems for DNA assembly for computer data storage |
| CN115023440B (zh) | 2019-09-23 | 2025-09-12 | 特韦斯特生物科学公司 | 结合CD3ε的抗体 |
| US12091777B2 (en) | 2019-09-23 | 2024-09-17 | Twist Bioscience Corporation | Variant nucleic acid libraries for CRTH2 |
| US11535842B2 (en) | 2019-10-11 | 2022-12-27 | Catalog Technologies, Inc. | Nucleic acid security and authentication |
| AU2020400030B2 (en) | 2019-12-09 | 2026-05-21 | Twist Bioscience Corporation | Variant nucleic acid libraries for adenosine receptors |
| BR112022021780A2 (pt) | 2020-04-27 | 2023-03-07 | Twist Bioscience Corp | Bibliotecas de ácido nucléico variantes para coronavírus |
| CA3183416A1 (en) | 2020-05-11 | 2021-11-18 | Catalog Technologies, Inc. | Programs and functions in dna-based data storage |
| CN111724841B (zh) * | 2020-06-04 | 2022-06-10 | 中国科学院上海微系统与信息技术研究所 | 一种基于生物蛋白的信息存储方法 |
| CA3190667A1 (en) | 2020-08-26 | 2022-03-03 | Aaron Sato | Methods and compositions relating to glp1r variants |
| US12534494B2 (en) | 2020-08-28 | 2026-01-27 | Twist Bioscience Corporation | Devices and methods for synthesis |
| EP4229210A4 (en) | 2020-10-19 | 2025-01-08 | Twist Bioscience Corporation | METHOD FOR THE SYNTHESIS OF OLIGONUCLEOTIDES USING BOUND NUCLEOTIDES |
| CN112711740A (zh) * | 2020-12-29 | 2021-04-27 | 湖北伯远合成生物科技有限公司 | 一种dna防伪标签系统 |
| WO2022159620A1 (en) | 2021-01-21 | 2022-07-28 | Twist Bioscience Corporation | Methods and compositions relating to adenosine receptors |
| US12258406B2 (en) | 2021-03-24 | 2025-03-25 | Twist Bioscience Corporation | Antibodies that bind CD3 Epsilon |
| WO2022235584A1 (en) | 2021-05-03 | 2022-11-10 | Twist Bioscience Corporation | Variant nucleic acid libraries for glycans |
| WO2022271884A2 (en) | 2021-06-22 | 2022-12-29 | Twist Bioscience Corporation | Methods and compositions relating to covid antibody epitopes |
| WO2023023285A2 (en) | 2021-08-19 | 2023-02-23 | Twist Bioscience Corporation | Methods and compositions relating to covalently closed nucleic acids |
| US12697597B2 (en) | 2021-11-01 | 2026-08-04 | Twist Bioscience Corporation | Methods for polynucleotide synthesis |
| EP4433085A2 (en) | 2021-11-18 | 2024-09-25 | Twist Bioscience Corporation | Dickkopf-1 variant antibodies and methods of use |
| US12325739B2 (en) | 2022-01-03 | 2025-06-10 | Twist Bioscience Corporation | Bispecific SARS-CoV-2 antibodies and methods of use |
| EP4490318A4 (en) | 2022-03-07 | 2026-06-10 | Twist Bioscience Corp | METHYLATION-MEDIATED ADAPTER ELIMINATION ON NUCLEIC ACID SEQUENCES |
| WO2024119052A2 (en) * | 2022-12-01 | 2024-06-06 | The Broad Institute, Inc. | Genomic cryptography |
| CN120197189B (zh) * | 2025-03-05 | 2025-11-18 | 广东工业大学 | 一种基于微流控技术的dna测序与加密方法 |
Family Cites Families (921)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3549368A (en) | 1968-07-02 | 1970-12-22 | Ibm | Process for improving photoresist adhesion |
| US3920714A (en) | 1972-11-16 | 1975-11-18 | Weber Heinrich | Process for the production of polymeric hydrocarbons with reactive silyl side groups |
| GB1550867A (en) | 1975-08-04 | 1979-08-22 | Hughes Aircraft Co | Positioning method and apparatus for fabricating microcircuit devices |
| US4415732A (en) | 1981-03-27 | 1983-11-15 | University Patents, Inc. | Phosphoramidite compounds and processes |
| EP0090789A1 (en) | 1982-03-26 | 1983-10-05 | Monsanto Company | Chemical DNA synthesis |
| US4994373A (en) | 1983-01-27 | 1991-02-19 | Enzo Biochem, Inc. | Method and structures employing chemically-labelled polynucleotide probes |
| JPS59224123A (ja) | 1983-05-20 | 1984-12-17 | Oki Electric Ind Co Ltd | ウエハアライメントマ−ク |
| US5118605A (en) | 1984-10-16 | 1992-06-02 | Chiron Corporation | Polynucleotide determination with selectable cleavage sites |
| JPS61141761A (ja) | 1984-12-12 | 1986-06-28 | Kanegafuchi Chem Ind Co Ltd | 硬化性組成物 |
| US5242794A (en) | 1984-12-13 | 1993-09-07 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
| US6492107B1 (en) | 1986-11-20 | 2002-12-10 | Stuart Kauffman | Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique |
| US4613398A (en) | 1985-06-06 | 1986-09-23 | International Business Machines Corporation | Formation of etch-resistant resists through preferential permeation |
| US4981797A (en) | 1985-08-08 | 1991-01-01 | Life Technologies, Inc. | Process of producing highly transformable cells and cells produced thereby |
| US4726877A (en) | 1986-01-22 | 1988-02-23 | E. I. Du Pont De Nemours And Company | Methods of using photosensitive compositions containing microgels |
| US4808511A (en) | 1987-05-19 | 1989-02-28 | International Business Machines Corporation | Vapor phase photoresist silylation process |
| JPH07113774B2 (ja) | 1987-05-29 | 1995-12-06 | 株式会社日立製作所 | パタ−ンの形成方法 |
| US4988617A (en) | 1988-03-25 | 1991-01-29 | California Institute Of Technology | Method of detecting a nucleotide change in nucleic acids |
| US5700637A (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
| EP0385410B1 (en) | 1989-02-28 | 1996-10-02 | Canon Kabushiki Kaisha | Partially double-stranded oligonucleotide and method for forming oligonucleotide |
| US5556750A (en) | 1989-05-12 | 1996-09-17 | Duke University | Methods and kits for fractionating a population of DNA molecules based on the presence or absence of a base-pair mismatch utilizing mismatch repair systems |
| US6008031A (en) | 1989-05-12 | 1999-12-28 | Duke University | Method of analysis and manipulation of DNA utilizing mismatch repair systems |
| US5459039A (en) | 1989-05-12 | 1995-10-17 | Duke University | Methods for mapping genetic mutations |
| US5102797A (en) | 1989-05-26 | 1992-04-07 | Dna Plant Technology Corporation | Introduction of heterologous genes into bacteria using transposon flanked expression cassette and a binary vector system |
| US5242974A (en) | 1991-11-22 | 1993-09-07 | Affymax Technologies N.V. | Polymer reversal on solid surfaces |
| US6919211B1 (en) | 1989-06-07 | 2005-07-19 | Affymetrix, Inc. | Polypeptide arrays |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| US5527681A (en) | 1989-06-07 | 1996-06-18 | Affymax Technologies N.V. | Immobilized molecular synthesis of systematically substituted compounds |
| US6309822B1 (en) | 1989-06-07 | 2001-10-30 | Affymetrix, Inc. | Method for comparing copy number of nucleic acid sequences |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| CA2036946C (en) | 1990-04-06 | 2001-10-16 | Kenneth V. Deugau | Indexing linkers |
| US5494810A (en) | 1990-05-03 | 1996-02-27 | Cornell Research Foundation, Inc. | Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease |
| US6087482A (en) | 1990-07-27 | 2000-07-11 | Isis Pharmaceuticals, Inc. | Heteroatomic oligonucleoside linkages |
| EP0738779B1 (en) | 1990-09-27 | 2004-05-19 | Invitrogen Corporation | Direct cloning of PCR amplified nucleic acids |
| GB9025236D0 (en) | 1990-11-20 | 1991-01-02 | Secr Defence | Silicon-on porous-silicon;method of production |
| US6582908B2 (en) | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
| DE69132905T2 (de) | 1990-12-06 | 2002-08-01 | Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) | Detektion von Nukleinsäuresequenzen |
| DK0562025T3 (da) | 1990-12-06 | 2001-06-18 | Affymetrix Inc | Forbindelser og deres anvendelse i en binær syntesestrategi |
| US5455166A (en) | 1991-01-31 | 1995-10-03 | Becton, Dickinson And Company | Strand displacement amplification |
| US5137814A (en) | 1991-06-14 | 1992-08-11 | Life Technologies, Inc. | Use of exo-sample nucleotides in gene cloning |
| US5449754A (en) | 1991-08-07 | 1995-09-12 | H & N Instruments, Inc. | Generation of combinatorial libraries |
| US5474796A (en) | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
| US7150982B2 (en) | 1991-09-09 | 2006-12-19 | Third Wave Technologies, Inc. | RNA detection assays |
| US5846717A (en) | 1996-01-24 | 1998-12-08 | Third Wave Technologies, Inc. | Detection of nucleic acid sequences by invader-directed cleavage |
| US7045289B2 (en) | 1991-09-09 | 2006-05-16 | Third Wave Technologies, Inc. | Detection of RNA Sequences |
| US6759226B1 (en) | 2000-05-24 | 2004-07-06 | Third Wave Technologies, Inc. | Enzymes for the detection of specific nucleic acid sequences |
| US5994069A (en) | 1996-01-24 | 1999-11-30 | Third Wave Technologies, Inc. | Detection of nucleic acids by multiple sequential invasive cleavages |
| US5384261A (en) | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
| DE69233087T2 (de) | 1991-11-22 | 2003-12-24 | Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) | Verfahren zur Herstellung von Polymerarrays |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| JP2775346B2 (ja) | 1992-04-03 | 1998-07-16 | アプライド バイオシステムズ，インコーポレイテッド | プローブ構成物および方法 |
| JP2553322Y2 (ja) | 1992-05-11 | 1997-11-05 | サンデン株式会社 | 飲料抽出装置のフィルタ送り機構 |
| JPH07509365A (ja) | 1992-07-31 | 1995-10-19 | デイド・ベーリング・マルブルク・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | ポリヌクレオチド類の３’末端に特定配列を導入する方法 |
| US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| JP3176444B2 (ja) | 1992-10-01 | 2001-06-18 | 株式会社リコー | 水性インク及びこれを用いた記録方法 |
| DE4241045C1 (de) | 1992-12-05 | 1994-05-26 | Bosch Gmbh Robert | Verfahren zum anisotropen Ätzen von Silicium |
| US5368823A (en) | 1993-02-11 | 1994-11-29 | University Of Georgia Research Foundation, Inc. | Automated synthesis of oligonucleotides |
| US5395753A (en) | 1993-02-19 | 1995-03-07 | Theratech, Inc. | Method for diagnosing rheumatoid arthritis |
| ES2204913T3 (es) | 1993-04-12 | 2004-05-01 | Northwestern University | Metodo para formacion de oligonucleotidos. |
| US7135312B2 (en) | 1993-04-15 | 2006-11-14 | University Of Rochester | Circular DNA vectors for synthesis of RNA and DNA |
| US5455239A (en) | 1993-08-05 | 1995-10-03 | Merck & Co. Inc. | 3-aryl of heteroaryl-7-heteroaralkylamido cephalosporin compounds, compositions and methods of use |
| US5482845A (en) | 1993-09-24 | 1996-01-09 | The Trustees Of Columbia University In The City Of New York | Method for construction of normalized cDNA libraries |
| CN1039623C (zh) | 1993-10-22 | 1998-09-02 | 中国人民解放军军事医学科学院毒物药物研究所 | 一种防治运动病综合征的药物组合物及其制备方法 |
| US6893816B1 (en) | 1993-10-28 | 2005-05-17 | Houston Advanced Research Center | Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions |
| WO1995011755A1 (en) | 1993-10-28 | 1995-05-04 | Houston Advanced Research Center | Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions |
| US6027877A (en) | 1993-11-04 | 2000-02-22 | Gene Check, Inc. | Use of immobilized mismatch binding protein for detection of mutations and polymorphisms, purification of amplified DNA samples and allele identification |
| US5834252A (en) | 1995-04-18 | 1998-11-10 | Glaxo Group Limited | End-complementary polymerase reaction |
| US6015880A (en) | 1994-03-16 | 2000-01-18 | California Institute Of Technology | Method and substrate for performing multiple sequential reactions on a matrix |
| ES2250969T3 (es) | 1994-03-29 | 2006-04-16 | Novozymes A/S | Amilasa alcalina de bacilo. |
| US5514789A (en) | 1994-04-21 | 1996-05-07 | Barrskogen, Inc. | Recovery of oligonucleotides by gas phase cleavage |
| SE512382C2 (sv) | 1994-04-26 | 2000-03-06 | Ericsson Telefon Ab L M | Anordning och förfarande för att placera långsträckta element mot eller invid en yta |
| JP2909216B2 (ja) | 1994-04-29 | 1999-06-23 | パーキン‐エルマー コーポレイション | 核酸増幅生成物のリアルタイム検出装置 |
| US6287850B1 (en) | 1995-06-07 | 2001-09-11 | Affymetrix, Inc. | Bioarray chip reaction apparatus and its manufacture |
| US5739386A (en) | 1994-06-23 | 1998-04-14 | Affymax Technologies N.V. | Photolabile compounds and methods for their use |
| US5641658A (en) | 1994-08-03 | 1997-06-24 | Mosaic Technologies, Inc. | Method for performing amplification of nucleic acid with two primers bound to a single solid support |
| US5530516A (en) | 1994-10-04 | 1996-06-25 | Tamarack Scientific Co., Inc. | Large-area projection exposure system |
| US6013445A (en) * | 1996-06-06 | 2000-01-11 | Lynx Therapeutics, Inc. | Massively parallel signature sequencing by ligation of encoded adaptors |
| US6613560B1 (en) | 1994-10-19 | 2003-09-02 | Agilent Technologies, Inc. | PCR microreactor for amplifying DNA using microquantities of sample fluid |
| US6635226B1 (en) | 1994-10-19 | 2003-10-21 | Agilent Technologies, Inc. | Microanalytical device and use thereof for conducting chemical processes |
| US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
| JPH11511900A (ja) | 1994-11-22 | 1999-10-12 | コンプレツクス フルイツド システムズ，インコーポレーテツド | マイクロエレクトロニクス用途のための非アミン系フォトレジスト密着促進剤 |
| US5688642A (en) | 1994-12-01 | 1997-11-18 | The United States Of America As Represented By The Secretary Of The Navy | Selective attachment of nucleic acid molecules to patterned self-assembled surfaces |
| US6017434A (en) | 1995-05-09 | 2000-01-25 | Curagen Corporation | Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments |
| US5830655A (en) | 1995-05-22 | 1998-11-03 | Sri International | Oligonucleotide sizing using cleavable primers |
| US5700642A (en) | 1995-05-22 | 1997-12-23 | Sri International | Oligonucleotide sizing using immobilized cleavable primers |
| US5877280A (en) | 1995-06-06 | 1999-03-02 | The Mount Sinai School Of Medicine Of The City University Of New York | Thermostable muts proteins |
| US6446682B1 (en) | 1995-06-06 | 2002-09-10 | James P. Viken | Auto-loading fluid exchanger and method of use |
| US5707806A (en) | 1995-06-07 | 1998-01-13 | Genzyme Corporation | Direct sequence identification of mutations by cleavage- and ligation-associated mutation-specific sequencing |
| US5712126A (en) | 1995-08-01 | 1998-01-27 | Yale University | Analysis of gene expression by display of 3-end restriction fragments of CDNA |
| US5780613A (en) | 1995-08-01 | 1998-07-14 | Northwestern University | Covalent lock for self-assembled oligonucleotide constructs |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| US6537776B1 (en) | 1999-06-14 | 2003-03-25 | Diversa Corporation | Synthetic ligation reassembly in directed evolution |
| US6352842B1 (en) | 1995-12-07 | 2002-03-05 | Diversa Corporation | Exonucease-mediated gene assembly in directed evolution |
| ATE236270T1 (de) | 1995-12-15 | 2003-04-15 | Univ Duke | Verfahren zum nachweis und zur entfernung von mutantsequenzen, die während enzymatischer amplifikation entstehen |
| US5962271A (en) | 1996-01-03 | 1999-10-05 | Cloutech Laboratories, Inc. | Methods and compositions for generating full-length cDNA having arbitrary nucleotide sequence at the 3'-end |
| US5976846A (en) | 1996-01-13 | 1999-11-02 | Passmore; Steven E. | Method for multifragment in vivo cloning and mutation mapping |
| WO1998023774A1 (en) | 1996-11-29 | 1998-06-04 | Third Wave Technologies, Inc. | Fen-1 endonucleases, mixtures and cleavage methods |
| US7122364B1 (en) | 1998-03-24 | 2006-10-17 | Third Wave Technologies, Inc. | FEN endonucleases |
| US7527928B2 (en) | 1996-11-29 | 2009-05-05 | Third Wave Technologies, Inc. | Reactions on a solid surface |
| US6090606A (en) | 1996-01-24 | 2000-07-18 | Third Wave Technologies, Inc. | Cleavage agents |
| US6706471B1 (en) | 1996-01-24 | 2004-03-16 | Third Wave Technologies, Inc. | Detection of nucleic acid sequences by invader-directed cleavage |
| US7432048B2 (en) | 1996-11-29 | 2008-10-07 | Third Wave Technologies, Inc. | Reactions on a solid surface |
| US5985557A (en) | 1996-01-24 | 1999-11-16 | Third Wave Technologies, Inc. | Invasive cleavage of nucleic acids |
| US6274369B1 (en) | 1996-02-02 | 2001-08-14 | Invitrogen Corporation | Method capable of increasing competency of bacterial cell transformation |
| US6013440A (en) | 1996-03-11 | 2000-01-11 | Affymetrix, Inc. | Nucleic acid affinity columns |
| US6020481A (en) | 1996-04-01 | 2000-02-01 | The Perkin-Elmer Corporation | Asymmetric benzoxanthene dyes |
| US6706875B1 (en) | 1996-04-17 | 2004-03-16 | Affyemtrix, Inc. | Substrate preparation process |
| US5869245A (en) | 1996-06-05 | 1999-02-09 | Fox Chase Cancer Center | Mismatch endonuclease and its use in identifying mutations in targeted polynucleotide strands |
| US5863801A (en) | 1996-06-14 | 1999-01-26 | Sarnoff Corporation | Automated nucleic acid isolation |
| US6780982B2 (en) | 1996-07-12 | 2004-08-24 | Third Wave Technologies, Inc. | Charge tags and the separation of nucleic acid molecules |
| US5853993A (en) | 1996-10-21 | 1998-12-29 | Hewlett-Packard Company | Signal enhancement method and kit |
| WO1998022541A2 (en) | 1996-11-08 | 1998-05-28 | Ikonos Corporation | Method for coating substrates |
| US5750672A (en) | 1996-11-22 | 1998-05-12 | Barrskogen, Inc. | Anhydrous amine cleavage of oligonucleotides |
| WO1998029736A1 (en) | 1996-12-31 | 1998-07-09 | Genometrix Incorporated | Multiplexed molecular analysis apparatus and method |
| EP1005529B1 (en) | 1997-02-12 | 2005-04-27 | Invitrogen Corporation | Methods for lyophilizing competent cells |
| US5882496A (en) | 1997-02-27 | 1999-03-16 | The Regents Of The University Of California | Porous silicon structures with high surface area/specific pore size |
| US6770748B2 (en) | 1997-03-07 | 2004-08-03 | Takeshi Imanishi | Bicyclonucleoside and oligonucleotide analogue |
| US6419883B1 (en) | 1998-01-16 | 2002-07-16 | University Of Washington | Chemical synthesis using solvent microdroplets |
| US6384210B1 (en) | 1997-03-20 | 2002-05-07 | University Of Washington | Solvent for biopolymer synthesis, solvent microdroplets and methods of use |
| US6028189A (en) | 1997-03-20 | 2000-02-22 | University Of Washington | Solvent for oligonucleotide synthesis and methods of use |
| EP1007718B1 (en) | 1997-03-21 | 2007-11-14 | Stratagene California | Polymerase enhancing factor (pef) extracts, pef protein complexes, isolated pef protein, and methods for purifying and identifying |
| US6969488B2 (en) | 1998-05-22 | 2005-11-29 | Solexa, Inc. | System and apparatus for sequential processing of analytes |
| US5922593A (en) | 1997-05-23 | 1999-07-13 | Becton, Dickinson And Company | Microbiological test panel and method therefor |
| WO1999000657A1 (en) | 1997-06-26 | 1999-01-07 | Perseptive Biosystems, Inc. | High density sample holder for analysis of biological samples |
| GB9714716D0 (en) | 1997-07-11 | 1997-09-17 | Brax Genomics Ltd | Characterising nucleic acids |
| US5989872A (en) | 1997-08-12 | 1999-11-23 | Clontech Laboratories, Inc. | Methods and compositions for transferring DNA sequence information among vectors |
| US6027898A (en) | 1997-08-18 | 2000-02-22 | Transgenomic, Inc. | Chromatographic method for mutation detection using mutation site specifically acting enzymes and chemicals |
| US6794499B2 (en) | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
| US6136568A (en) | 1997-09-15 | 2000-10-24 | Hiatt; Andrew C. | De novo polynucleotide synthesis using rolling templates |
| US6670127B2 (en) | 1997-09-16 | 2003-12-30 | Egea Biosciences, Inc. | Method for assembly of a polynucleotide encoding a target polypeptide |
| ES2243007T3 (es) | 1997-09-16 | 2005-11-16 | Egea Biosciences Llc | Sintesis quimica completa y sintesis de genes de genomas. |
| US5976842A (en) | 1997-10-30 | 1999-11-02 | Clontech Laboratories, Inc. | Methods and compositions for use in high fidelity polymerase chain reaction |
| US8182991B1 (en) | 1997-11-26 | 2012-05-22 | Third Wave Technologies, Inc. | FEN-1 endonucleases, mixtures and cleavage methods |
| US6408308B1 (en) | 1998-01-29 | 2002-06-18 | Incyte Pharmaceuticals, Inc. | System and method for generating, analyzing and storing normalized expression datasets from raw expression datasets derived from microarray includes nucleic acid probe sequences |
| US6287776B1 (en) | 1998-02-02 | 2001-09-11 | Signature Bioscience, Inc. | Method for detecting and classifying nucleic acid hybridization |
| US6537747B1 (en) * | 1998-02-03 | 2003-03-25 | Lucent Technologies Inc. | Data transmission using DNA oligomers |
| US6251588B1 (en) | 1998-02-10 | 2001-06-26 | Agilent Technologies, Inc. | Method for evaluating oligonucleotide probe sequences |
| AU755239B2 (en) | 1998-02-11 | 2002-12-05 | University Of Houston, The | Method and apparatus for chemical and biochemical reactions using photo-generated reagents |
| WO1999042813A1 (en) | 1998-02-23 | 1999-08-26 | Wisconsin Alumni Research Foundation | Method and apparatus for synthesis of arrays of dna probes |
| WO1999049079A1 (en) | 1998-03-25 | 1999-09-30 | Ulf Landegren | Rolling circle replication of padlock probes |
| US6284497B1 (en) | 1998-04-09 | 2001-09-04 | Trustees Of Boston University | Nucleic acid arrays and methods of synthesis |
| CA2325013A1 (en) | 1998-04-13 | 1999-10-21 | Isis Pharmaceuticals Inc. | Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation |
| US7321828B2 (en) | 1998-04-13 | 2008-01-22 | Isis Pharmaceuticals, Inc. | System of components for preparing oligonucleotides |
| US6376285B1 (en) | 1998-05-28 | 2002-04-23 | Texas Instruments Incorporated | Annealed porous silicon with epitaxial layer for SOI |
| US6274725B1 (en) | 1998-06-02 | 2001-08-14 | Isis Pharmaceuticals, Inc. | Activators for oligonucleotide synthesis |
| US6130045A (en) | 1998-06-11 | 2000-10-10 | Clontech Laboratories, Inc. | Thermostable polymerase |
| US6251595B1 (en) | 1998-06-18 | 2001-06-26 | Agilent Technologies, Inc. | Methods and devices for carrying out chemical reactions |
| ATE313548T1 (de) | 1998-06-22 | 2006-01-15 | Affymetrix Inc | Reagenz und verfahren zu fester phase synthese |
| US7399844B2 (en) | 1998-07-09 | 2008-07-15 | Agilent Technologies, Inc. | Method and reagents for analyzing the nucleotide sequence of nucleic acids |
| US6218118B1 (en) | 1998-07-09 | 2001-04-17 | Agilent Technologies, Inc. | Method and mixture reagents for analyzing the nucleotide sequence of nucleic acids by mass spectrometry |
| US6787308B2 (en) | 1998-07-30 | 2004-09-07 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
| US20030022207A1 (en) | 1998-10-16 | 2003-01-30 | Solexa, Ltd. | Arrayed polynucleotides and their use in genome analysis |
| US6222030B1 (en) | 1998-08-03 | 2001-04-24 | Agilent Technologies, Inc. | Solid phase synthesis of oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection |
| US6991922B2 (en) | 1998-08-12 | 2006-01-31 | Proteus S.A. | Process for in vitro creation of recombinant polynucleotide sequences by oriented ligation |
| US6951719B1 (en) | 1999-08-11 | 2005-10-04 | Proteus S.A. | Process for obtaining recombined nucleotide sequences in vitro, libraries of sequences and sequences thus obtained |
| US6107038A (en) | 1998-08-14 | 2000-08-22 | Agilent Technologies Inc. | Method of binding a plurality of chemicals on a substrate by electrophoretic self-assembly |
| DE19940752A1 (de) | 1998-08-28 | 2000-04-27 | Febit Ferrarius Biotech Gmbh | Verfahren zur Herstellung eines mit biologisch oder chemisch funktionellen Materialien beschichteten Trägers (BioChip) |
| US6258454B1 (en) | 1998-09-01 | 2001-07-10 | Agilent Technologies Inc. | Functionalization of substrate surfaces with silane mixtures |
| US6461812B2 (en) | 1998-09-09 | 2002-10-08 | Agilent Technologies, Inc. | Method and multiple reservoir apparatus for fabrication of biomolecular arrays |
| US6458583B1 (en) | 1998-09-09 | 2002-10-01 | Agilent Technologies, Inc. | Method and apparatus for making nucleic acid arrays |
| WO2000015779A2 (en) | 1998-09-15 | 2000-03-23 | Yale University | Molecular cloning using rolling circle amplification |
| AR021833A1 (es) | 1998-09-30 | 2002-08-07 | Applied Research Systems | Metodos de amplificacion y secuenciacion de acido nucleico |
| US6399516B1 (en) | 1998-10-30 | 2002-06-04 | Massachusetts Institute Of Technology | Plasma etch techniques for fabricating silicon structures from a substrate |
| US6309828B1 (en) | 1998-11-18 | 2001-10-30 | Agilent Technologies, Inc. | Method and apparatus for fabricating replicate arrays of nucleic acid molecules |
| GB9900298D0 (en) | 1999-01-07 | 1999-02-24 | Medical Res Council | Optical sorting method |
| US6376246B1 (en) | 1999-02-05 | 2002-04-23 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
| AU2415200A (en) | 1999-01-18 | 2000-08-01 | Maxygen, Inc. | Methods of populating data structures for use in evolutionary simulations |
| JP2002534965A (ja) | 1999-01-19 | 2002-10-22 | マキシジェン， インコーポレイテッド | 所望の特徴を有する文字ストリング、ポリヌクレオチドおよびポリペプチドを作製するための方法 |
| US20070065838A1 (en) | 1999-01-19 | 2007-03-22 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
| US6251685B1 (en) | 1999-02-18 | 2001-06-26 | Agilent Technologies, Inc. | Readout method for molecular biological electronically addressable arrays |
| ATE334197T1 (de) | 1999-02-19 | 2006-08-15 | Febit Biotech Gmbh | Verfahren zur herstellung von polymeren |
| ATE508200T1 (de) | 1999-02-23 | 2011-05-15 | Caliper Life Sciences Inc | Sequenzierung durch inkorporation |
| WO2000053617A1 (en) | 1999-03-08 | 2000-09-14 | Protogene Laboratories, Inc. | Methods and compositions for economically synthesizing and assembling long dna sequences |
| US6824866B1 (en) | 1999-04-08 | 2004-11-30 | Affymetrix, Inc. | Porous silica substrates for polymer synthesis and assays |
| US6284465B1 (en) | 1999-04-15 | 2001-09-04 | Agilent Technologies, Inc. | Apparatus, systems and method for locating nucleic acids bound to surfaces |
| US6469156B1 (en) | 1999-04-20 | 2002-10-22 | The United States Of America As Represented By The Department Of Health And Human Services | Rapid and sensitive method for detecting histoplasma capsulatum |
| US6221653B1 (en) | 1999-04-27 | 2001-04-24 | Agilent Technologies, Inc. | Method of performing array-based hybridization assays using thermal inkjet deposition of sample fluids |
| US6773676B2 (en) | 1999-04-27 | 2004-08-10 | Agilent Technologies, Inc. | Devices for performing array hybridization assays and methods of using the same |
| US6518056B2 (en) | 1999-04-27 | 2003-02-11 | Agilent Technologies Inc. | Apparatus, systems and method for assaying biological materials using an annular format |
| US6300137B1 (en) | 1999-04-28 | 2001-10-09 | Agilent Technologies Inc. | Method for synthesizing a specific, surface-bound polymer uniformly over an element of a molecular array |
| US6323043B1 (en) | 1999-04-30 | 2001-11-27 | Agilent Technologies, Inc. | Fabricating biopolymer arrays |
| US7276336B1 (en) | 1999-07-22 | 2007-10-02 | Agilent Technologies, Inc. | Methods of fabricating an addressable array of biopolymer probes |
| US6242266B1 (en) | 1999-04-30 | 2001-06-05 | Agilent Technologies Inc. | Preparation of biopolymer arrays |
| JP2003516169A (ja) | 1999-05-01 | 2003-05-13 | プシメデイカ・リミテツド | 誘導多孔性シリコン |
| AU4703300A (en) | 1999-05-06 | 2000-11-21 | Mount Sinai School Of Medicine Of The City University Of New York, The | Dna-based steganography |
| US7056661B2 (en) | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
| WO2000071559A1 (en) | 1999-05-24 | 2000-11-30 | Invitrogen Corporation | Method for deblocking of labeled oligonucleotides |
| US6472147B1 (en) | 1999-05-25 | 2002-10-29 | The Scripps Research Institute | Methods for display of heterodimeric proteins on filamentous phage using pVII and pIX, compositions, vectors and combinatorial libraries |
| US6132997A (en) | 1999-05-28 | 2000-10-17 | Agilent Technologies | Method for linear mRNA amplification |
| US6815218B1 (en) | 1999-06-09 | 2004-11-09 | Massachusetts Institute Of Technology | Methods for manufacturing bioelectronic devices |
| US6709852B1 (en) | 1999-06-22 | 2004-03-23 | Invitrogen Corporation | Rapid growing microorganisms for biotechnology applications |
| US7537886B1 (en) | 1999-06-22 | 2009-05-26 | Life Technologies Corporation | Primers and methods for the detection and discrimination of nucleic acids |
| DE19928410C2 (de) | 1999-06-22 | 2002-11-28 | Agilent Technologies Inc | Gerätegehäuse mit einer Einrichtung zum Betrieb eines Labor-Mikrochips |
| US6399394B1 (en) | 1999-06-30 | 2002-06-04 | Agilent Technologies, Inc. | Testing multiple fluid samples with multiple biopolymer arrays |
| US6465183B2 (en) | 1999-07-01 | 2002-10-15 | Agilent Technologies, Inc. | Multidentate arrays |
| US7504213B2 (en) | 1999-07-09 | 2009-03-17 | Agilent Technologies, Inc. | Methods and apparatus for preparing arrays comprising features having degenerate biopolymers |
| US6461816B1 (en) | 1999-07-09 | 2002-10-08 | Agilent Technologies, Inc. | Methods for controlling cross-hybridization in analysis of nucleic acid sequences |
| US6346423B1 (en) | 1999-07-16 | 2002-02-12 | Agilent Technologies, Inc. | Methods and compositions for producing biopolymeric arrays |
| US6306599B1 (en) | 1999-07-16 | 2001-10-23 | Agilent Technologies Inc. | Biopolymer arrays and their fabrication |
| US6201112B1 (en) | 1999-07-22 | 2001-03-13 | Agilent Technologies Inc. | Method for 3′ end-labeling ribonucleic acids |
| US6180351B1 (en) | 1999-07-22 | 2001-01-30 | Agilent Technologies Inc. | Chemical array fabrication with identifier |
| ATE542916T1 (de) | 1999-08-18 | 2012-02-15 | Illumina Inc | Methoden zur erzeugung von oligonukleotidlösungen |
| US6262490B1 (en) | 1999-11-05 | 2001-07-17 | Advanced Semiconductor Engineering, Inc. | Substrate strip for use in packaging semiconductor chips |
| US7211390B2 (en) | 1999-09-16 | 2007-05-01 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| US6743585B2 (en) | 1999-09-16 | 2004-06-01 | Agilent Technologies, Inc. | Methods for preparing conjugates |
| US7244559B2 (en) | 1999-09-16 | 2007-07-17 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| US6319674B1 (en) | 1999-09-16 | 2001-11-20 | Agilent Technologies, Inc. | Methods for attaching substances to surfaces |
| US7122303B2 (en) | 1999-09-17 | 2006-10-17 | Agilent Technologies, Inc. | Arrays comprising background features that provide for a measure of a non-specific binding and methods for using the same |
| US7078167B2 (en) | 1999-09-17 | 2006-07-18 | Agilent Technologies, Inc. | Arrays having background features and methods for using the same |
| WO2001023610A2 (en) | 1999-09-29 | 2001-04-05 | Solexa Ltd. | Polynucleotide sequencing |
| DE19964337B4 (de) | 1999-10-01 | 2004-09-16 | Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto | Mikrofluidischer Mikrochip mit abbiegbarem Ansaugrohr |
| AU1075701A (en) | 1999-10-08 | 2001-04-23 | Protogene Laboratories, Inc. | Method and apparatus for performing large numbers of reactions using array assembly |
| US6232072B1 (en) | 1999-10-15 | 2001-05-15 | Agilent Technologies, Inc. | Biopolymer array inspection |
| US6451998B1 (en) | 1999-10-18 | 2002-09-17 | Agilent Technologies, Inc. | Capping and de-capping during oligonucleotide synthesis |
| US6171797B1 (en) | 1999-10-20 | 2001-01-09 | Agilent Technologies Inc. | Methods of making polymeric arrays |
| US7115423B1 (en) | 1999-10-22 | 2006-10-03 | Agilent Technologies, Inc. | Fluidic structures within an array package |
| US6387636B1 (en) | 1999-10-22 | 2002-05-14 | Agilent Technologies, Inc. | Method of shielding biosynthesis reactions from the ambient environment on an array |
| US6077674A (en) | 1999-10-27 | 2000-06-20 | Agilent Technologies Inc. | Method of producing oligonucleotide arrays with features of high purity |
| US6329210B1 (en) | 1999-10-29 | 2001-12-11 | Agilent Technologies, Inc. | Method and apparatus for high volume polymer synthesis |
| US6689319B1 (en) | 1999-10-29 | 2004-02-10 | Agilent Technologies, Ind. | Apparatus for deposition and inspection of chemical and biological fluids |
| US8268605B2 (en) | 1999-10-29 | 2012-09-18 | Agilent Technologies, Inc. | Compositions and methods utilizing DNA polymerases |
| US6406849B1 (en) | 1999-10-29 | 2002-06-18 | Agilent Technologies, Inc. | Interrogating multi-featured arrays |
| US20010055761A1 (en) | 1999-10-29 | 2001-12-27 | Agilent Technologies | Small scale dna synthesis using polymeric solid support with functionalized regions |
| US6428957B1 (en) | 1999-11-08 | 2002-08-06 | Agilent Technologies, Inc. | Systems tools and methods of assaying biological materials using spatially-addressable arrays |
| US6440669B1 (en) | 1999-11-10 | 2002-08-27 | Agilent Technologies, Inc. | Methods for applying small volumes of reagents |
| US7041445B2 (en) | 1999-11-15 | 2006-05-09 | Clontech Laboratories, Inc. | Long oligonucleotide arrays |
| US6446642B1 (en) | 1999-11-22 | 2002-09-10 | Agilent Technologies, Inc. | Method and apparatus to clean an inkjet reagent deposition device |
| US6582938B1 (en) | 2001-05-11 | 2003-06-24 | Affymetrix, Inc. | Amplification of nucleic acids |
| US6800439B1 (en) | 2000-01-06 | 2004-10-05 | Affymetrix, Inc. | Methods for improved array preparation |
| SG121902A1 (en) | 2000-01-11 | 2006-05-26 | Maxygen Inc | Integrated systems for diversity generation and screening |
| EP1118661A1 (en) | 2000-01-13 | 2001-07-25 | Het Nederlands Kanker Instituut | T cell receptor libraries |
| EP1252513A4 (en) | 2000-01-25 | 2007-07-18 | Affymetrix Inc | METHOD, SYSTEM AND SOFTWARE FOR OFFERING A GENOMIC WEB PORTAL |
| US6587579B1 (en) | 2000-01-26 | 2003-07-01 | Agilent Technologies Inc. | Feature quality in array fabrication |
| US6406851B1 (en) | 2000-01-28 | 2002-06-18 | Agilent Technologies, Inc. | Method for coating a substrate quickly and uniformly with a small volume of fluid |
| US7198939B2 (en) | 2000-01-28 | 2007-04-03 | Agilent Technologies, Inc. | Apparatus for interrogating an addressable array |
| US6458526B1 (en) | 2000-01-28 | 2002-10-01 | Agilent Technologies, Inc. | Method and apparatus to inhibit bubble formation in a fluid |
| US6235483B1 (en) | 2000-01-31 | 2001-05-22 | Agilent Technologies, Inc. | Methods and kits for indirect labeling of nucleic acids |
| GB0002389D0 (en) | 2000-02-02 | 2000-03-22 | Solexa Ltd | Molecular arrays |
| US6403314B1 (en) | 2000-02-04 | 2002-06-11 | Agilent Technologies, Inc. | Computational method and system for predicting fragmented hybridization and for identifying potential cross-hybridization |
| US6833450B1 (en) | 2000-03-17 | 2004-12-21 | Affymetrix, Inc. | Phosphite ester oxidation in nucleic acid array preparation |
| US6365355B1 (en) | 2000-03-28 | 2002-04-02 | The Regents Of The University Of California | Chimeric proteins for detection and quantitation of DNA mutations, DNA sequence variations, DNA damage and DNA mismatches |
| US20020025561A1 (en) | 2000-04-17 | 2002-02-28 | Hodgson Clague Pitman | Vectors for gene-self-assembly |
| US7776021B2 (en) | 2000-04-28 | 2010-08-17 | The Charles Stark Draper Laboratory | Micromachined bilayer unit for filtration of small molecules |
| US7163660B2 (en) | 2000-05-31 | 2007-01-16 | Infineon Technologies Ag | Arrangement for taking up liquid analytes |
| US6716634B1 (en) | 2000-05-31 | 2004-04-06 | Agilent Technologies, Inc. | Increasing ionization efficiency in mass spectrometry |
| US6664112B2 (en) | 2000-06-02 | 2003-12-16 | Blue Heron Biotechnology, Inc. | Methods for improving the sequence fidelity of synthetic double-stranded oligonucleotides |
| US7399599B2 (en) | 2000-07-10 | 2008-07-15 | Vertex Pharmaceuticals (San Diego) Llc | Ion channel assay methods |
| CA2416952A1 (en) | 2000-07-27 | 2002-02-07 | The Australian National University | Combinatorial probes and uses therefor |
| EP1176151B1 (en) | 2000-07-28 | 2014-08-20 | Agilent Technologies, Inc. | Synthesis of polynucleotides using combined oxidation/deprotection chemistry |
| US6890760B1 (en) | 2000-07-31 | 2005-05-10 | Agilent Technologies, Inc. | Array fabrication |
| US6599693B1 (en) | 2000-07-31 | 2003-07-29 | Agilent Technologies Inc. | Array fabrication |
| US6613893B1 (en) | 2000-07-31 | 2003-09-02 | Agilent Technologies Inc. | Array fabrication |
| EP1180548B1 (en) | 2000-07-31 | 2005-11-02 | Agilent Technologies, Inc. (a Delaware corporation) | Array based methods for synthesizing nucleic acid mixtures |
| US7205400B2 (en) | 2000-07-31 | 2007-04-17 | Agilent Technologies, Inc. | Array fabrication |
| GB0018876D0 (en) | 2000-08-01 | 2000-09-20 | Applied Research Systems | Method of producing polypeptides |
| JP2004527215A (ja) | 2000-08-24 | 2004-09-09 | マキシジェン， インコーポレイテッド | 構築物、および代謝経路操作におけるそれらの使用 |
| CA2421266A1 (en) | 2000-09-08 | 2002-03-14 | Richard T. Pon | Linker phosphoramidites for oligonucleotide synthesis |
| US6966945B1 (en) | 2000-09-20 | 2005-11-22 | Goodrich Corporation | Inorganic matrix compositions, composites and process of making the same |
| US6897023B2 (en) | 2000-09-27 | 2005-05-24 | The Molecular Sciences Institute, Inc. | Method for determining relative abundance of nucleic acid sequences |
| NO20004869D0 (no) | 2000-09-28 | 2000-09-28 | Torbjoern Rognes | Metode for hurtig optimal lokal sekvensjustering ved bruk av parallell prosessering |
| US7097809B2 (en) | 2000-10-03 | 2006-08-29 | California Institute Of Technology | Combinatorial synthesis system |
| JP4361271B2 (ja) | 2000-10-10 | 2009-11-11 | バイオトローブ・インコーポレイテツド | アッセイ、合成、および保存用の器具、ならびに、その作製、使用、および操作の方法 |
| US6693187B1 (en) | 2000-10-17 | 2004-02-17 | Lievre Cornu Llc | Phosphinoamidite carboxlates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge |
| DE10051396A1 (de) | 2000-10-17 | 2002-04-18 | Febit Ferrarius Biotech Gmbh | Verfahren und Vorrichtung zur integrierten Synthese und Analytbestimmung an einem Träger |
| JP2004512607A (ja) | 2000-10-18 | 2004-04-22 | ウルトラ プロイズヴォドニャ エレクトロンスキ ナプラウ デー．オー．オー． | 支払いデータ交換システム及びそのシステムにて用いられる支払い端末装置 |
| DE60125312T2 (de) | 2000-10-26 | 2007-06-06 | Agilent Technologies, Inc. (n.d. Ges. d. Staates Delaware), Santa Clara | Mikroarray |
| US6905816B2 (en) | 2000-11-27 | 2005-06-14 | Intelligent Medical Devices, Inc. | Clinically intelligent diagnostic devices and methods |
| US20020155439A1 (en) | 2000-12-04 | 2002-10-24 | Ana Rodriguez | Method for generating a library of mutant oligonucleotides using the linear cyclic amplification reaction |
| US20040253242A1 (en) | 2000-12-05 | 2004-12-16 | Bowdish Katherine S. | Rationally designed antibodies |
| DE10060433B4 (de) | 2000-12-05 | 2006-05-11 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Verfahren zur Herstellung eines Fluidbauelements, Fluidbauelement und Analysevorrichtung |
| US6768005B2 (en) | 2000-12-20 | 2004-07-27 | Avecia Limited | Process |
| AU2002220870A1 (en) | 2000-12-05 | 2002-06-18 | Avecia Limited | Process for the preparation of phosphorothionate oligonucleotides |
| US6660475B2 (en) | 2000-12-15 | 2003-12-09 | New England Biolabs, Inc. | Use of site-specific nicking endonucleases to create single-stranded regions and applications thereof |
| AUPR259301A0 (en) | 2001-01-18 | 2001-02-15 | Polymerat Pty Ltd | Polymers having co-continuous architecture |
| KR100860291B1 (ko) | 2001-01-19 | 2008-09-25 | 에게아 바이오사이언시스, 인크. | 표적 폴리펩티드를 암호화하는 폴리뉴클레오티드의 컴퓨터지시된 어셈블리 |
| US6958217B2 (en) | 2001-01-24 | 2005-10-25 | Genomic Expression Aps | Single-stranded polynucleotide tags |
| US7027930B2 (en) | 2001-01-31 | 2006-04-11 | Agilent Technologies, Inc. | Reading chemical arrays |
| US7166258B2 (en) | 2001-01-31 | 2007-01-23 | Agilent Technologies, Inc. | Automation-optimized microarray package |
| US6879915B2 (en) | 2001-01-31 | 2005-04-12 | Agilent Technologies, Inc. | Chemical array fabrication and use |
| US20020164824A1 (en) | 2001-02-16 | 2002-11-07 | Jianming Xiao | Method and apparatus based on bundled capillaries for high throughput screening |
| US6660338B1 (en) | 2001-03-08 | 2003-12-09 | Agilent Technologies, Inc. | Functionalization of substrate surfaces with silane mixtures |
| ATE312841T1 (de) | 2001-03-08 | 2005-12-15 | Applera Corp | Verfahren zum entschützen von oligonukleotide |
| US7211654B2 (en) | 2001-03-14 | 2007-05-01 | Regents Of The University Of Michigan | Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports |
| EP2801624B1 (en) | 2001-03-16 | 2019-03-06 | Singular Bio, Inc | Arrays and methods of use |
| US6610978B2 (en) | 2001-03-27 | 2003-08-26 | Agilent Technologies, Inc. | Integrated sample preparation, separation and introduction microdevice for inductively coupled plasma mass spectrometry |
| US7208322B2 (en) | 2001-04-02 | 2007-04-24 | Agilent Technologies, Inc. | Sensor surfaces for detecting analytes |
| US20030022240A1 (en) | 2001-04-17 | 2003-01-30 | Peizhi Luo | Generation and affinity maturation of antibody library in silico |
| US6943036B2 (en) | 2001-04-30 | 2005-09-13 | Agilent Technologies, Inc. | Error detection in chemical array fabrication |
| CA2446417A1 (en) | 2001-05-03 | 2002-11-14 | Sigma Genosys, L.P. | Methods for assembling protein microarrays |
| IL158487A0 (en) | 2001-05-18 | 2004-05-12 | Wisconsin Alumni Res Found | Method for the synthesis of dna sequences |
| WO2002094846A2 (en) | 2001-05-22 | 2002-11-28 | Parallel Synthesis Technologies, Inc. | Method for in situ, on-chip chemical synthesis |
| US6880576B2 (en) | 2001-06-07 | 2005-04-19 | Nanostream, Inc. | Microfluidic devices for methods development |
| US6649348B2 (en) | 2001-06-29 | 2003-11-18 | Agilent Technologies Inc. | Methods for manufacturing arrays |
| US6613523B2 (en) | 2001-06-29 | 2003-09-02 | Agilent Technologies, Inc. | Method of DNA sequencing using cleavable tags |
| US20040161741A1 (en) | 2001-06-30 | 2004-08-19 | Elazar Rabani | Novel compositions and processes for analyte detection, quantification and amplification |
| US6989267B2 (en) | 2001-07-02 | 2006-01-24 | Agilent Technologies, Inc. | Methods of making microarrays with substrate surfaces having covalently bound polyelectrolyte films |
| US6753145B2 (en) | 2001-07-05 | 2004-06-22 | Agilent Technologies, Inc. | Buffer composition and method for hybridization of microarrays on adsorbed polymer siliceous surfaces |
| US7205399B1 (en) | 2001-07-06 | 2007-04-17 | Sirna Therapeutics, Inc. | Methods and reagents for oligonucleotide synthesis |
| US7314599B2 (en) | 2001-07-17 | 2008-01-01 | Agilent Technologies, Inc. | Paek embossing and adhesion for microfluidic devices |
| US7128876B2 (en) | 2001-07-17 | 2006-10-31 | Agilent Technologies, Inc. | Microdevice and method for component separation in a fluid |
| US6702256B2 (en) | 2001-07-17 | 2004-03-09 | Agilent Technologies, Inc. | Flow-switching microdevice |
| US20030108903A1 (en) | 2001-07-19 | 2003-06-12 | Liman Wang | Multiple word DNA computing on surfaces |
| DE60232523D1 (de) | 2001-07-26 | 2009-07-16 | Stratagene California | Multi-stellen-mutagenese |
| WO2003014325A2 (en) | 2001-08-10 | 2003-02-20 | Xencor | Protein design automation for protein libraries |
| US6682702B2 (en) | 2001-08-24 | 2004-01-27 | Agilent Technologies, Inc. | Apparatus and method for simultaneously conducting multiple chemical reactions |
| US7371580B2 (en) | 2001-08-24 | 2008-05-13 | Agilent Technologies, Inc. | Use of unstructured nucleic acids in assaying nucleic acid molecules |
| JP2003101204A (ja) | 2001-09-25 | 2003-04-04 | Nec Kansai Ltd | 配線基板及び配線基板の製造方法並びに電子部品 |
| US20050124022A1 (en) | 2001-10-30 | 2005-06-09 | Maithreyan Srinivasan | Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
| US6902921B2 (en) | 2001-10-30 | 2005-06-07 | 454 Corporation | Sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
| US6858720B2 (en) | 2001-10-31 | 2005-02-22 | Agilent Technologies, Inc. | Method of synthesizing polynucleotides using ionic liquids |
| US7524950B2 (en) | 2001-10-31 | 2009-04-28 | Agilent Technologies, Inc. | Uses of cationic salts for polynucleotide synthesis |
| US6852850B2 (en) | 2001-10-31 | 2005-02-08 | Agilent Technologies, Inc. | Use of ionic liquids for fabrication of polynucleotide arrays |
| WO2003040410A1 (en) | 2001-11-02 | 2003-05-15 | Nimblegen Systems, Inc. | Detection of hybridization oligonucleotide microarray through covalently labeling microarray probe |
| US7195872B2 (en) | 2001-11-09 | 2007-03-27 | 3D Biosurfaces, Inc. | High surface area substrates for microarrays and methods to make same |
| US7482118B2 (en) | 2001-11-15 | 2009-01-27 | Third Wave Technologies, Inc. | Endonuclease-substrate complexes |
| ATE414767T1 (de) | 2001-11-22 | 2008-12-15 | Sloning Biotechnology Gmbh | Nukleinsäure-linker und deren verwendung in der gensynthese |
| US20030099952A1 (en) | 2001-11-26 | 2003-05-29 | Roland Green | Microarrays with visible pattern detection |
| US6927029B2 (en) | 2001-12-03 | 2005-08-09 | Agilent Technologies, Inc. | Surface with tethered polymeric species for binding biomolecules |
| AU2002365811A1 (en) | 2001-12-03 | 2003-06-17 | Zymogenetics, Inc. | Methods for the selection and cloning of nucleic acid molecules free of unwanted nucleotide sequence alterations |
| AU2002357249A1 (en) | 2001-12-13 | 2003-07-09 | Blue Heron Biotechnology, Inc. | Methods for removal of double-stranded oligonucleotides containing sequence errors using mismatch recognition proteins |
| US6838888B2 (en) | 2001-12-13 | 2005-01-04 | Agilent Technologies, Inc. | Flow cell humidity sensor system |
| US7932070B2 (en) | 2001-12-21 | 2011-04-26 | Agilent Technologies, Inc. | High fidelity DNA polymerase compositions and uses therefor |
| US7282183B2 (en) | 2001-12-24 | 2007-10-16 | Agilent Technologies, Inc. | Atmospheric control in reaction chambers |
| US6790620B2 (en) | 2001-12-24 | 2004-09-14 | Agilent Technologies, Inc. | Small volume chambers |
| US6846454B2 (en) | 2001-12-24 | 2005-01-25 | Agilent Technologies, Inc. | Fluid exit in reaction chambers |
| WO2003057924A1 (en) | 2002-01-04 | 2003-07-17 | Board Of Regents, The University Of Texas System | Proofreading, error deletion, and ligation method for synthesis of high-fidelity polynucleotide sequences |
| US7025324B1 (en) | 2002-01-04 | 2006-04-11 | Massachusetts Institute Of Technology | Gating apparatus and method of manufacture |
| US6673552B2 (en) | 2002-01-14 | 2004-01-06 | Diversa Corporation | Methods for purifying annealed double-stranded oligonucleotides lacking base pair mismatches or nucleotide gaps |
| JP2005514927A (ja) | 2002-01-14 | 2005-05-26 | ディヴァーサ コーポレイション | ポリヌクレオチドの製造方法及び二本鎖ポリヌクレオチドの精製方法 |
| US20040009498A1 (en) | 2002-01-14 | 2004-01-15 | Diversa Corporation | Chimeric antigen binding molecules and methods for making and using them |
| US7141368B2 (en) | 2002-01-30 | 2006-11-28 | Agilent Technologies, Inc. | Multi-directional deposition in array fabrication |
| US20040126757A1 (en) | 2002-01-31 | 2004-07-01 | Francesco Cerrina | Method and apparatus for synthesis of arrays of DNA probes |
| US7422851B2 (en) | 2002-01-31 | 2008-09-09 | Nimblegen Systems, Inc. | Correction for illumination non-uniformity during the synthesis of arrays of oligomers |
| US7037659B2 (en) | 2002-01-31 | 2006-05-02 | Nimblegen Systems Inc. | Apparatus for constructing DNA probes having a prismatic and kaleidoscopic light homogenizer |
| US7157229B2 (en) | 2002-01-31 | 2007-01-02 | Nimblegen Systems, Inc. | Prepatterned substrate for optical synthesis of DNA probes |
| US7083975B2 (en) | 2002-02-01 | 2006-08-01 | Roland Green | Microarray synthesis instrument and method |
| US20030148291A1 (en) | 2002-02-05 | 2003-08-07 | Karla Robotti | Method of immobilizing biologically active molecules for assay purposes in a microfluidic format |
| US6728129B2 (en) | 2002-02-19 | 2004-04-27 | The Regents Of The University Of California | Multistate triple-decker dyads in three distinct architectures for information storage applications |
| US6958119B2 (en) | 2002-02-26 | 2005-10-25 | Agilent Technologies, Inc. | Mobile phase gradient generation microfluidic device |
| US6770892B2 (en) | 2002-02-28 | 2004-08-03 | Agilent Technologies, Inc. | Method and system for automated focus-distance determination for molecular array scanners |
| US6914229B2 (en) | 2002-02-28 | 2005-07-05 | Agilent Technologies, Inc. | Signal offset for prevention of data clipping in a molecular array scanner |
| US6929951B2 (en) | 2002-02-28 | 2005-08-16 | Agilent Technologies, Inc. | Method and system for molecular array scanner calibration |
| US20050084907A1 (en) | 2002-03-01 | 2005-04-21 | Maxygen, Inc. | Methods, systems, and software for identifying functional biomolecules |
| US6919181B2 (en) | 2002-03-25 | 2005-07-19 | Agilent Technologies, Inc. | Methods for generating ligand arrays |
| US20030228602A1 (en) | 2002-04-01 | 2003-12-11 | Blue Heron Biotechnology, Inc. | Solid phase methods for polynucleotide production |
| EP1350853A1 (en) | 2002-04-05 | 2003-10-08 | ID-Lelystad, Instituut voor Dierhouderij en Diergezondheid B.V. | Detection of polymorphisms |
| US6773888B2 (en) | 2002-04-08 | 2004-08-10 | Affymetrix, Inc. | Photoactivatable silane compounds and methods for their synthesis and use |
| ATE401422T1 (de) | 2002-04-22 | 2008-08-15 | Genencor Int | Verfahren zur erzeugung einer bibliothek aus bakterienklonen mit unterschiedlichen genexpressionsniveaus |
| GB0209539D0 (en) | 2002-04-26 | 2002-06-05 | Avecia Ltd | Monomer Polymer and process |
| US6946285B2 (en) | 2002-04-29 | 2005-09-20 | Agilent Technologies, Inc. | Arrays with elongated features |
| US7125523B2 (en) | 2002-04-29 | 2006-10-24 | Agilent Technologies, Inc. | Holders for arrays |
| US7094537B2 (en) | 2002-04-30 | 2006-08-22 | Agilent Technologies, Inc. | Micro arrays with structured and unstructured probes |
| US6621076B1 (en) | 2002-04-30 | 2003-09-16 | Agilent Technologies, Inc. | Flexible assembly for transporting sample fluids into a mass spectrometer |
| AU2003233243A1 (en) | 2002-05-06 | 2003-11-17 | Noxxon Pharma Ag | Method for amplifying nucleic acids |
| US20030211478A1 (en) | 2002-05-08 | 2003-11-13 | Gentel Corporation | Transcription factor profiling on a solid surface |
| US7221785B2 (en) | 2002-05-21 | 2007-05-22 | Agilent Technologies, Inc. | Method and system for measuring a molecular array background signal from a continuous background region of specified size |
| US7273730B2 (en) | 2002-05-24 | 2007-09-25 | Invitrogen Corporation | Nested PCR employing degradable primers |
| ATE513923T1 (de) | 2002-05-24 | 2011-07-15 | Roche Nimblegen Inc | Mikroarrays und verfahren zur durchführung einer hybridisierungsreaktion für mehrere proben auf einem einzigen mikroarray |
| US6789965B2 (en) | 2002-05-31 | 2004-09-14 | Agilent Technologies, Inc. | Dot printer with off-axis loading |
| US7537936B2 (en) | 2002-05-31 | 2009-05-26 | Agilent Technologies, Inc. | Method of testing multiple fluid samples with multiple biopolymer arrays |
| US7078505B2 (en) | 2002-06-06 | 2006-07-18 | Agilent Technologies, Inc. | Manufacture of arrays with varying deposition parameters |
| US6939673B2 (en) | 2002-06-14 | 2005-09-06 | Agilent Technologies, Inc. | Manufacture of arrays with reduced error impact |
| US7351379B2 (en) | 2002-06-14 | 2008-04-01 | Agilent Technologies, Inc. | Fluid containment structure |
| US7919308B2 (en) | 2002-06-14 | 2011-04-05 | Agilent Technologies, Inc. | Form in place gaskets for assays |
| US7371348B2 (en) | 2002-06-14 | 2008-05-13 | Agilent Technologies | Multiple array format |
| US7220573B2 (en) | 2002-06-21 | 2007-05-22 | Agilent Technologies, Inc. | Array assay devices and methods of using the same |
| US6713262B2 (en) | 2002-06-25 | 2004-03-30 | Agilent Technologies, Inc. | Methods and compositions for high throughput identification of protein/nucleic acid binding pairs |
| US7894998B2 (en) | 2002-06-26 | 2011-02-22 | Agilent Technologies, Inc. | Method for identifying suitable nucleic acid probe sequences for use in nucleic acid arrays |
| US7202358B2 (en) | 2002-07-25 | 2007-04-10 | Agilent Technologies, Inc. | Methods for producing ligand arrays |
| US7452712B2 (en) | 2002-07-30 | 2008-11-18 | Applied Biosystems Inc. | Sample block apparatus and method of maintaining a microcard on a sample block |
| US6835938B2 (en) | 2002-07-31 | 2004-12-28 | Agilent Technologies, Inc. | Biopolymer array substrate thickness dependent automated focus-distance determination method for biopolymer array scanners |
| US7101508B2 (en) | 2002-07-31 | 2006-09-05 | Agilent Technologies, Inc. | Chemical array fabrication errors |
| US7153689B2 (en) | 2002-08-01 | 2006-12-26 | Agilent Technologies, Inc. | Apparatus and methods for cleaning and priming droplet dispensing devices |
| US8946387B2 (en) | 2002-08-14 | 2015-02-03 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
| US7205128B2 (en) | 2002-08-16 | 2007-04-17 | Agilent Technologies, Inc. | Method for synthesis of the second strand of cDNA |
| US7563600B2 (en) | 2002-09-12 | 2009-07-21 | Combimatrix Corporation | Microarray synthesis and assembly of gene-length polynucleotides |
| US20040166567A1 (en) | 2002-09-26 | 2004-08-26 | Santi Daniel V | Synthetic genes |
| WO2004029586A1 (en) | 2002-09-27 | 2004-04-08 | Nimblegen Systems, Inc. | Microarray with hydrophobic barriers |
| CA2500936C (en) | 2002-09-30 | 2012-10-30 | Nimblegen Systems, Inc. | Parallel loading of arrays |
| WO2004031351A2 (en) | 2002-10-01 | 2004-04-15 | Nimblegen Systems, Inc. | Microarrays having multiple oligonucleotides in single array features |
| US7129075B2 (en) | 2002-10-18 | 2006-10-31 | Transgenomic, Inc. | Isolated CEL II endonuclease |
| US8283148B2 (en) | 2002-10-25 | 2012-10-09 | Agilent Technologies, Inc. | DNA polymerase compositions for quantitative PCR and methods thereof |
| AU2003287237A1 (en) | 2002-10-28 | 2004-05-25 | Xeotron Corporation | Array oligomer synthesis and use. |
| US7364896B2 (en) | 2002-10-31 | 2008-04-29 | Agilent Technologies, Inc. | Test strips including flexible array substrates and method of hybridization |
| WO2004040295A1 (en) | 2002-10-31 | 2004-05-13 | Nanostream, Inc. | Parallel detection chromatography systems |
| US7422911B2 (en) | 2002-10-31 | 2008-09-09 | Agilent Technologies, Inc. | Composite flexible array substrate having flexible support |
| US7629120B2 (en) | 2002-10-31 | 2009-12-08 | Rice University | Method for assembling PCR fragments of DNA |
| US7390457B2 (en) | 2002-10-31 | 2008-06-24 | Agilent Technologies, Inc. | Integrated microfluidic array device |
| US7402279B2 (en) | 2002-10-31 | 2008-07-22 | Agilent Technologies, Inc. | Device with integrated microfluidic and electronic components |
| US20040086892A1 (en) | 2002-11-06 | 2004-05-06 | Crothers Donald M. | Universal tag assay |
| US7029854B2 (en) | 2002-11-22 | 2006-04-18 | Agilent Technologies, Inc. | Methods designing multiple mRNA transcript nucleic acid probe sequences for use in nucleic acid arrays |
| US7062385B2 (en) | 2002-11-25 | 2006-06-13 | Tufts University | Intelligent electro-optical nucleic acid-based sensor array and method for detecting volatile compounds in ambient air |
| JP4754219B2 (ja) | 2002-12-02 | 2011-08-24 | アムジエン・フレモント・インコーポレイテツド | 腫瘍壊死因子を対象とする抗体、およびそれらの使用 |
| US20040110133A1 (en) | 2002-12-06 | 2004-06-10 | Affymetrix, Inc. | Functionated photoacid generator for biological microarray synthesis |
| US7932025B2 (en) | 2002-12-10 | 2011-04-26 | Massachusetts Institute Of Technology | Methods for high fidelity production of long nucleic acid molecules with error control |
| US7879580B2 (en) | 2002-12-10 | 2011-02-01 | Massachusetts Institute Of Technology | Methods for high fidelity production of long nucleic acid molecules |
| US6987263B2 (en) | 2002-12-13 | 2006-01-17 | Nanostream, Inc. | High throughput systems and methods for parallel sample analysis |
| US20060076482A1 (en) | 2002-12-13 | 2006-04-13 | Hobbs Steven E | High throughput systems and methods for parallel sample analysis |
| US7247337B1 (en) | 2002-12-16 | 2007-07-24 | Agilent Technologies, Inc. | Method and apparatus for microarray fabrication |
| US20040191810A1 (en) | 2002-12-17 | 2004-09-30 | Affymetrix, Inc. | Immersed microarrays in conical wells |
| GB0229443D0 (en) | 2002-12-18 | 2003-01-22 | Avecia Ltd | Process |
| US7960157B2 (en) | 2002-12-20 | 2011-06-14 | Agilent Technologies, Inc. | DNA polymerase blends and uses thereof |
| ES2367430T3 (es) | 2002-12-23 | 2011-11-03 | Wyeth Llc | Anticuerpos contra pd-1 y sus usos. |
| EP1576192B1 (en) | 2002-12-23 | 2014-10-29 | Agilent Technologies, Inc. | Comparative genomic hybridization assays using immobilized oligonucleotide features and compositions for practicing the same |
| WO2004058391A2 (de) | 2002-12-23 | 2004-07-15 | Febit Biotech Gmbh | Photoaktivierbare zweistufige schutzgruppen für die synthese von biopolymeren |
| DE10260805A1 (de) | 2002-12-23 | 2004-07-22 | Geneart Gmbh | Verfahren und Vorrichtung zum Optimieren einer Nucleotidsequenz zur Expression eines Proteins |
| US7372982B2 (en) | 2003-01-14 | 2008-05-13 | Agilent Technologies, Inc. | User interface for molecular array feature analysis |
| US6809277B2 (en) | 2003-01-22 | 2004-10-26 | Agilent Technologies, Inc. | Method for registering a deposited material with channel plate channels, and switch produced using same |
| DE602004026033D1 (de) | 2003-01-29 | 2010-04-29 | 454 Corp | Zweiendige sequenzierung |
| US7202264B2 (en) | 2003-01-31 | 2007-04-10 | Isis Pharmaceuticals, Inc. | Supports for oligomer synthesis |
| US8073626B2 (en) | 2003-01-31 | 2011-12-06 | Agilent Technologies, Inc. | Biopolymer array reading |
| US6950756B2 (en) | 2003-02-05 | 2005-09-27 | Agilent Technologies, Inc. | Rearrangement of microarray scan images to form virtual arrays |
| US7413709B2 (en) | 2003-02-12 | 2008-08-19 | Agilent Technologies, Inc. | PAEK-based microfluidic device with integrated electrospray emitter |
| GB2398383B (en) | 2003-02-12 | 2005-03-09 | Global Genomics Ab | Method and means for nucleic acid sequencing |
| US7244513B2 (en) | 2003-02-21 | 2007-07-17 | Nano-Proprietary, Inc. | Stain-etched silicon powder |
| US7070932B2 (en) | 2003-02-25 | 2006-07-04 | Agilent Technologies, Inc. | Methods and devices for detecting printhead misalignment of an in situ polymeric array synthesis device |
| US7252938B2 (en) | 2003-02-25 | 2007-08-07 | Agilent Technologies, Inc. | Methods and devices for producing a polymer at a location of a substrate |
| US6977223B2 (en) | 2003-03-07 | 2005-12-20 | Massachusetts Institute Of Technology | Three dimensional microfabrication |
| US20050053968A1 (en) * | 2003-03-31 | 2005-03-10 | Council Of Scientific And Industrial Research | Method for storing information in DNA |
| US7534561B2 (en) | 2003-04-02 | 2009-05-19 | Agilent Technologies, Inc. | Nucleic acid array in situ fabrication methods and arrays produced using the same |
| WO2004090170A1 (en) | 2003-04-02 | 2004-10-21 | Blue Heron Biotechnology, Inc. | Error reduction in automated gene synthesis |
| US7206439B2 (en) | 2003-04-30 | 2007-04-17 | Agilent Technologies, Inc. | Feature locations in array reading |
| US7269518B2 (en) | 2003-04-30 | 2007-09-11 | Agilent Technologies, Inc. | Chemical array reading |
| US20040219663A1 (en) | 2003-04-30 | 2004-11-04 | Page Robert D. | Biopolymer array fabrication using different drop deposition heads |
| US6916113B2 (en) | 2003-05-16 | 2005-07-12 | Agilent Technologies, Inc. | Devices and methods for fluid mixing |
| CA2526368A1 (en) | 2003-05-20 | 2004-12-02 | Fluidigm Corporation | Method and system for microfluidic device and imaging thereof |
| CA2531197A1 (en) | 2003-05-30 | 2005-01-06 | The Board Of Trustees Of The University Of Illinois | Gene expression profiles that identify genetically elite ungulate mammals |
| EP1660512A4 (en) | 2003-06-02 | 2009-12-23 | Isis Pharmaceuticals Inc | SYNTHESIS OF OLIGONUCLEOTIDES USING ALTERNATIVE SOLVENTS |
| US8133670B2 (en) | 2003-06-13 | 2012-03-13 | Cold Spring Harbor Laboratory | Method for making populations of defined nucleic acid molecules |
| US6938476B2 (en) | 2003-06-25 | 2005-09-06 | Agilent Technologies, Inc. | Apparatus and methods for sensing fluid levels |
| US7534563B2 (en) | 2003-06-30 | 2009-05-19 | Agilent Technologies, Inc. | Methods for producing ligand arrays |
| US20050016851A1 (en) | 2003-07-24 | 2005-01-27 | Jensen Klavs F. | Microchemical method and apparatus for synthesis and coating of colloidal nanoparticles |
| US6843281B1 (en) | 2003-07-30 | 2005-01-18 | Agilent Techinologies, Inc. | Methods and apparatus for introducing liquids into microfluidic chambers |
| US7353116B2 (en) | 2003-07-31 | 2008-04-01 | Agilent Technologies, Inc. | Chemical array with test dependent signal reading or processing |
| US7939310B2 (en) | 2003-08-06 | 2011-05-10 | University Of Massachusetts | Systems and methods for analyzing nucleic acid sequences |
| US7028536B2 (en) | 2004-06-29 | 2006-04-18 | Nanostream, Inc. | Sealing interface for microfluidic device |
| US7348144B2 (en) | 2003-08-13 | 2008-03-25 | Agilent Technologies, Inc. | Methods and system for multi-drug treatment discovery |
| US7229497B2 (en) | 2003-08-26 | 2007-06-12 | Massachusetts Institute Of Technology | Method of preparing nanocrystals |
| US7417139B2 (en) | 2003-08-30 | 2008-08-26 | Agilent Technologies, Inc. | Method for polynucleotide synthesis |
| US7427679B2 (en) | 2003-08-30 | 2008-09-23 | Agilent Technologies, Inc. | Precursors for two-step polynucleotide synthesis |
| US7585970B2 (en) | 2003-08-30 | 2009-09-08 | Agilent Technologies, Inc. | Method of polynucleotide synthesis using modified support |
| US7385050B2 (en) | 2003-08-30 | 2008-06-10 | Agilent Technologies, Inc. | Cleavable linker for polynucleotide synthesis |
| US7193077B2 (en) | 2003-08-30 | 2007-03-20 | Agilent Technologies, Inc. | Exocyclic amine triaryl methyl protecting groups in two-step polynucleotide synthesis |
| US20050049796A1 (en) | 2003-09-03 | 2005-03-03 | Webb Peter G. | Methods for encoding non-biological information on microarrays |
| WO2005023993A2 (en) | 2003-09-09 | 2005-03-17 | Integrigen, Inc. | Methods and compositions for generation of germline human antibody genes |
| EP1687445A4 (en) | 2003-09-23 | 2007-03-28 | Atom Sciences Inc | POLYMERIC NUCLEIC ACID HYBRIDIZATION SUBSTANCES |
| US7488607B2 (en) | 2003-09-30 | 2009-02-10 | Agilent Technologies, Inc. | Electronically readable microarray with electronic addressing function |
| US7147362B2 (en) | 2003-10-15 | 2006-12-12 | Agilent Technologies, Inc. | Method of mixing by intermittent centrifugal force |
| US7075161B2 (en) | 2003-10-23 | 2006-07-11 | Agilent Technologies, Inc. | Apparatus and method for making a low capacitance artificial nanopore |
| US20050277125A1 (en) | 2003-10-27 | 2005-12-15 | Massachusetts Institute Of Technology | High-density reaction chambers and methods of use |
| US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
| US7276338B2 (en) | 2003-11-17 | 2007-10-02 | Jacobson Joseph M | Nucleotide sequencing via repetitive single molecule hybridization |
| DE10353887A1 (de) | 2003-11-18 | 2005-06-16 | Febit Ag | Hochparalleler DNA-Synthesizer auf Matrizenbasis |
| US7851192B2 (en) | 2004-11-22 | 2010-12-14 | New England Biolabs, Inc. | Modified DNA cleavage enzymes and methods for use |
| US7282705B2 (en) | 2003-12-19 | 2007-10-16 | Agilent Technologies, Inc. | Microdevice having an annular lining for producing an electrospray emitter |
| EP2789383B1 (en) | 2004-01-07 | 2023-05-03 | Illumina Cambridge Limited | Molecular arrays |
| US7084180B2 (en) | 2004-01-28 | 2006-08-01 | Velocys, Inc. | Fischer-tropsch synthesis using microchannel technology and novel catalyst and microchannel reactor |
| WO2005073410A2 (en) | 2004-01-28 | 2005-08-11 | 454 Corporation | Nucleic acid amplification with continuous flow emulsion |
| JP2007521833A (ja) | 2004-02-12 | 2007-08-09 | コンパス ジェネティクス エルエルシー | 配列特異的分類による遺伝的分析 |
| US7125488B2 (en) | 2004-02-12 | 2006-10-24 | Varian, Inc. | Polar-modified bonded phase materials for chromatographic separations |
| EP1733055A4 (en) | 2004-02-27 | 2009-03-11 | Harvard College | polynucleotide |
| WO2005093092A2 (en) | 2004-03-26 | 2005-10-06 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g-protein coupled receptor 44 (gpr44) |
| US7875463B2 (en) | 2004-03-26 | 2011-01-25 | Agilent Technologies, Inc. | Generalized pulse jet ejection head control model |
| US20050214778A1 (en) | 2004-03-29 | 2005-09-29 | Peck Bill J | Methods for in situ generation of nucleic acid arrays |
| US20050214779A1 (en) | 2004-03-29 | 2005-09-29 | Peck Bill J | Methods for in situ generation of nucleic acid arrays |
| US8825411B2 (en) | 2004-05-04 | 2014-09-02 | Dna Twopointo, Inc. | Design, synthesis and assembly of synthetic nucleic acids |
| US20060010513A1 (en) | 2004-05-11 | 2006-01-12 | Melville Mark W | Oligonucleotide arrays to monitor gene expression and methods for making and using same |
| PT1773978E (pt) | 2004-05-19 | 2014-05-29 | Massachusetts Inst Technology | Modelo de doença com células/tecidos tri-dimensionais perfundidos |
| US7302348B2 (en) | 2004-06-02 | 2007-11-27 | Agilent Technologies, Inc. | Method and system for quantifying and removing spatial-intensity trends in microarray data |
| US20060024711A1 (en) | 2004-07-02 | 2006-02-02 | Helicos Biosciences Corporation | Methods for nucleic acid amplification and sequence determination |
| ATE528396T1 (de) | 2004-07-06 | 2011-10-15 | Bioren Inc | Look-through-mutagenese zur entwicklung veränderter polypeptide mit verbesserten eigenschaften |
| US7811753B2 (en) | 2004-07-14 | 2010-10-12 | Ibis Biosciences, Inc. | Methods for repairing degraded DNA |
| US7276720B2 (en) | 2004-07-19 | 2007-10-02 | Helicos Biosciences Corporation | Apparatus and methods for analyzing samples |
| US20060012793A1 (en) | 2004-07-19 | 2006-01-19 | Helicos Biosciences Corporation | Apparatus and methods for analyzing samples |
| US20060019084A1 (en) | 2004-07-23 | 2006-01-26 | Pearson Laurence T | Monolithic composition and method |
| US20060024678A1 (en) | 2004-07-28 | 2006-02-02 | Helicos Biosciences Corporation | Use of single-stranded nucleic acid binding proteins in sequencing |
| CA2575490A1 (en) | 2004-08-03 | 2006-02-16 | Frank Notka | Method for modulating gene expression by altering the cpg content |
| WO2006073504A2 (en) | 2004-08-04 | 2006-07-13 | President And Fellows Of Harvard College | Wobble sequencing |
| WO2006018044A1 (en) | 2004-08-18 | 2006-02-23 | Agilent Technologies, Inc. | Microfluidic assembly with coupled microfluidic devices |
| US7034290B2 (en) | 2004-09-24 | 2006-04-25 | Agilent Technologies, Inc. | Target support with pattern recognition sites |
| US7943046B2 (en) | 2004-10-01 | 2011-05-17 | Agilent Technologies, Inc | Methods and systems for on-column protein delipidation |
| US20070122817A1 (en) | 2005-02-28 | 2007-05-31 | George Church | Methods for assembly of high fidelity synthetic polynucleotides |
| AU2005295351A1 (en) | 2004-10-18 | 2006-04-27 | Codon Devices, Inc. | Methods for assembly of high fidelity synthetic polynucleotides |
| US7141807B2 (en) | 2004-10-22 | 2006-11-28 | Agilent Technologies, Inc. | Nanowire capillaries for mass spectrometry |
| US20060110744A1 (en) | 2004-11-23 | 2006-05-25 | Sampas Nicolas M | Probe design methods and microarrays for comparative genomic hybridization and location analysis |
| US8380441B2 (en) | 2004-11-30 | 2013-02-19 | Agilent Technologies, Inc. | Systems for producing chemical array layouts |
| US7977119B2 (en) | 2004-12-08 | 2011-07-12 | Agilent Technologies, Inc. | Chemical arrays and methods of using the same |
| US11268149B2 (en) | 2004-12-08 | 2022-03-08 | Cedars-Sinai Medical Center | Diagnosis and treatment of inflammatory bowel disease |
| US7439272B2 (en) | 2004-12-20 | 2008-10-21 | Varian, Inc. | Ultraporous sol gel monoliths |
| EP1841788A4 (en) | 2004-12-22 | 2009-01-21 | Univ Singapore | NEW TOXIN FROM A SERPENT |
| US20070099196A1 (en) | 2004-12-29 | 2007-05-03 | Sakari Kauppinen | Novel oligonucleotide compositions and probe sequences useful for detection and analysis of micrornas and their target mRNAs |
| JP2008526259A (ja) | 2005-01-13 | 2008-07-24 | コドン デバイシズ インコーポレイテッド | 蛋白質デザインのための組成物及び方法 |
| US20060171855A1 (en) | 2005-02-03 | 2006-08-03 | Hongfeng Yin | Devices,systems and methods for multi-dimensional separation |
| US20090088679A1 (en) | 2005-02-07 | 2009-04-02 | Massachusetts Institute Of Technology | Electronically-Degradable Layer-by-Layer Thin Films |
| US7393665B2 (en) | 2005-02-10 | 2008-07-01 | Population Genetics Technologies Ltd | Methods and compositions for tagging and identifying polynucleotides |
| JP4641199B2 (ja) | 2005-02-28 | 2011-03-02 | 国立感染症研究所長 | Ｒｎａ干渉ポリヌクレオチド混合物の設計装置、ｒｎａ干渉ポリヌクレオチド混合物の作製方法、及びｒｎａ干渉ポリヌクレオチド混合物の設計プログラム |
| US20060203236A1 (en) | 2005-03-08 | 2006-09-14 | Zhenghua Ji | Sample cell |
| EP1623763A1 (en) | 2005-03-11 | 2006-02-08 | Agilent Technologies, Inc. | Chip with cleaning cavity |
| US7618777B2 (en) | 2005-03-16 | 2009-11-17 | Agilent Technologies, Inc. | Composition and method for array hybridization |
| US20060219637A1 (en) | 2005-03-29 | 2006-10-05 | Killeen Kevin P | Devices, systems and methods for liquid chromatography |
| EP1874792B1 (en) | 2005-04-27 | 2016-04-13 | Sigma-Aldrich Co. LLC | Activators for oligonucleotide and phosphoramidite synthesis |
| DE602006015633D1 (de) | 2005-04-29 | 2010-09-02 | Synthetic Genomics Inc | Amplifikation und klonierung einzelner dna-moleküle mittels rolling-circle-amplifikation |
| US7572907B2 (en) | 2005-04-29 | 2009-08-11 | Agilent Technologies, Inc. | Methods and compounds for polynucleotide synthesis |
| KR101544954B1 (ko) | 2005-05-12 | 2015-08-18 | 헴펠 에이/에스 | 내크랙성 에폭시 도막의 형성 방법 및 상기 방법에 적절한 페인트 조성물 |
| US7396676B2 (en) | 2005-05-31 | 2008-07-08 | Agilent Technologies, Inc. | Evanescent wave sensor with attached ligand |
| DK1907571T3 (en) | 2005-06-15 | 2017-08-21 | Complete Genomics Inc | NUCLEIC ACID ANALYSIS USING INCIDENTAL MIXTURES OF NON-OVERLAPPING FRAGMENTS |
| US7919239B2 (en) | 2005-07-01 | 2011-04-05 | Agilent Technologies, Inc. | Increasing hybridization efficiencies |
| US8076064B2 (en) | 2005-07-09 | 2011-12-13 | Agilent Technologies, Inc. | Method of treatment of RNA sample |
| US7718365B2 (en) | 2005-07-09 | 2010-05-18 | Agilent Technologies, Inc. | Microarray analysis of RNA |
| DK1924704T3 (da) | 2005-08-02 | 2011-09-05 | Rubicon Genomics Inc | Sammensætninger og fremgangsmåder til bearbejdning og mangfoldiggørelse af DNA, herunder ved anvendelse af flere enzymer i en enkelt reaktion |
| DE102005037351B3 (de) | 2005-08-08 | 2007-01-11 | Geneart Ag | Verfahren für die kontinuierliche zielgerichtete Evolution von Proteinen in vitro |
| US9404882B2 (en) | 2005-08-11 | 2016-08-02 | New Mexico Tech Research Foundation | Method of producing a multi-microchannel, flow-through element and device using same |
| WO2007032837A2 (en) | 2005-08-11 | 2007-03-22 | The J. Craig Venter Institute | Method for in vitro recombination |
| DK1915446T3 (en) | 2005-08-11 | 2017-09-11 | Synthetic Genomics Inc | IN VITRO RECOMBINATION PROCEDURE |
| US7749701B2 (en) | 2005-08-11 | 2010-07-06 | Agilent Technologies, Inc. | Controlling use of oligonucleotide sequences released from arrays |
| US7805252B2 (en) | 2005-08-16 | 2010-09-28 | Dna Twopointo, Inc. | Systems and methods for designing and ordering polynucleotides |
| WO2007025059A1 (en) | 2005-08-26 | 2007-03-01 | Surmodics, Inc. | Silane coating compositions, coating systems, and methods |
| US20070196834A1 (en) | 2005-09-09 | 2007-08-23 | Francesco Cerrina | Method and system for the generation of large double stranded DNA fragments |
| EP1939621B1 (en) | 2005-09-16 | 2014-11-19 | Azbil Corporation | Method for manufacturing substrate for biochip, and method for manufacturing biochip |
| US20080308884A1 (en) | 2005-10-13 | 2008-12-18 | Silex Microsystems Ab | Fabrication of Inlet and Outlet Connections for Microfluidic Chips |
| US8202985B2 (en) | 2005-10-31 | 2012-06-19 | Agilent Technologies, Inc. | Monomer compositions for the synthesis of polynucleotides, methods of synthesis, and methods of deprotection |
| US7368550B2 (en) | 2005-10-31 | 2008-05-06 | Agilent Technologies, Inc. | Phosphorus protecting groups |
| US8552174B2 (en) | 2005-10-31 | 2013-10-08 | Agilent Technologies, Inc. | Solutions, methods, and processes for deprotection of polynucleotides |
| US7759471B2 (en) | 2005-10-31 | 2010-07-20 | Agilent Technologies, Inc. | Monomer compositions for the synthesis of RNA, methods of synthesis, and methods of deprotection |
| GB0522310D0 (en) | 2005-11-01 | 2005-12-07 | Solexa Ltd | Methods of preparing libraries of template polynucleotides |
| US7291471B2 (en) | 2005-11-21 | 2007-11-06 | Agilent Technologies, Inc. | Cleavable oligonucleotide arrays |
| GB0524069D0 (en) | 2005-11-25 | 2006-01-04 | Solexa Ltd | Preparation of templates for solid phase amplification |
| US8137936B2 (en) | 2005-11-29 | 2012-03-20 | Macevicz Stephen C | Selected amplification of polynucleotides |
| US20090247415A1 (en) | 2005-12-22 | 2009-10-01 | Keygene N.V. | Strategies for trranscript profiling using high throughput sequencing technologies |
| US7939645B2 (en) | 2006-01-06 | 2011-05-10 | Agilent Technologies, Inc | Reaction buffer composition for nucleic acid replication with packed DNA polymerases |
| WO2007081385A2 (en) | 2006-01-11 | 2007-07-19 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
| EP1987162A4 (en) | 2006-01-23 | 2009-11-25 | Population Genetics Technologi | NUCLEIC ACID ANALYSIS ABOUT SEQUENCE TOKENS |
| US20070207487A1 (en) | 2006-01-25 | 2007-09-06 | Emig Christopher J | Photoelectrochemical synthesis of high density combinatorial polymer arrays |
| WO2008057127A2 (en) | 2006-02-06 | 2008-05-15 | Massachusetts Institute Of Technology | Self-assembly of macromolecules on multilayered polymer surfaces |
| US8809876B2 (en) | 2006-02-14 | 2014-08-19 | Massachusetts Institute Of Technology | Absorbing film |
| US7807356B2 (en) | 2006-03-09 | 2010-10-05 | Agilent Technologies, Inc. | Labeled nucleotide composition |
| TW200806317A (en) | 2006-03-20 | 2008-02-01 | Wyeth Corp | Methods for reducing protein aggregation |
| US7572908B2 (en) | 2006-03-23 | 2009-08-11 | Agilent Technologies, Inc. | Cleavable linkers for polynucleotides |
| US7855281B2 (en) | 2006-03-23 | 2010-12-21 | Agilent Technologies, Inc. | Cleavable thiocarbonate linkers for polynucleotide synthesis |
| US20070231800A1 (en) | 2006-03-28 | 2007-10-04 | Agilent Technologies, Inc. | Determination of methylated DNA |
| SG170802A1 (en) | 2006-03-31 | 2011-05-30 | Solexa Inc | Systems and devices for sequence by synthesis analysis |
| US20070238106A1 (en) | 2006-04-07 | 2007-10-11 | Agilent Technologies, Inc. | Systems and methods of determining alleles and/or copy numbers |
| US20070238108A1 (en) | 2006-04-07 | 2007-10-11 | Agilent Technologies, Inc. | Validation of comparative genomic hybridization |
| US20070238104A1 (en) | 2006-04-07 | 2007-10-11 | Agilent Technologies, Inc. | Competitive oligonucleotides |
| US8058055B2 (en) | 2006-04-07 | 2011-11-15 | Agilent Technologies, Inc. | High resolution chromosomal mapping |
| AU2007234733A1 (en) | 2006-04-07 | 2007-10-18 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Antibody compositions and methods for treatment of neoplastic disease |
| US20100173364A1 (en) | 2006-04-11 | 2010-07-08 | New England Biolabs, Inc. | Repair of Nucleic Acids for Improved Amplification |
| AU2007237909A1 (en) | 2006-04-19 | 2007-10-25 | Applied Biosystems, Llc. | Reagents, methods, and libraries for gel-free bead-based sequencing |
| US8383338B2 (en) | 2006-04-24 | 2013-02-26 | Roche Nimblegen, Inc. | Methods and systems for uniform enrichment of genomic regions |
| US20070259346A1 (en) | 2006-05-03 | 2007-11-08 | Agilent Technologies, Inc. | Analysis of arrays |
| US20070259345A1 (en) | 2006-05-03 | 2007-11-08 | Agilent Technologies, Inc. | Target determination using compound probes |
| US20070259347A1 (en) | 2006-05-03 | 2007-11-08 | Agilent Technologies, Inc. | Methods of increasing the effective probe densities of arrays |
| US20070259344A1 (en) | 2006-05-03 | 2007-11-08 | Agilent Technologies, Inc. | Compound probes and methods of increasing the effective probe densities of arrays |
| WO2007137242A2 (en) | 2006-05-19 | 2007-11-29 | Massachusetts Institute Of Technology | Microfluidic-based gene synthesis |
| US20090087840A1 (en) | 2006-05-19 | 2009-04-02 | Codon Devices, Inc. | Combined extension and ligation for nucleic acid assembly |
| WO2008054543A2 (en) | 2006-05-20 | 2008-05-08 | Codon Devices, Inc. | Oligonucleotides for multiplex nucleic acid assembly |
| EP2035984A4 (en) | 2006-06-19 | 2010-03-31 | Yeda Res & Dev | PROGRAMMABLE ITERATED ELONGATION: PROCESS FOR THE MANUFACTURE OF SYNTHETIC GENES AND COMBINATORY DNA AND PROTEIN LIBRARIES |
| AT503861B1 (de) | 2006-07-05 | 2008-06-15 | F Star Biotech Forsch & Entw | Verfahren zur manipulation von t-zell-rezeptoren |
| AT503902B1 (de) | 2006-07-05 | 2008-06-15 | F Star Biotech Forsch & Entw | Verfahren zur manipulation von immunglobulinen |
| US20080193772A1 (en) | 2006-07-07 | 2008-08-14 | Bio-Rad Laboratories, Inc | Mass spectrometry probes having hydrophobic coatiings |
| US9328378B2 (en) | 2006-07-31 | 2016-05-03 | Illumina Cambridge Limited | Method of library preparation avoiding the formation of adaptor dimers |
| US7524942B2 (en) | 2006-07-31 | 2009-04-28 | Agilent Technologies, Inc. | Labeled nucleotide composition |
| US7572585B2 (en) | 2006-07-31 | 2009-08-11 | Agilent Technologies, Inc. | Enzymatic labeling of RNA |
| JP2010500011A (ja) | 2006-08-08 | 2010-01-07 | ガンサー ハートマン | ５’リン酸オリゴヌクレオチドの構造および使用 |
| DE102006039479A1 (de) | 2006-08-23 | 2008-03-06 | Febit Biotech Gmbh | Programmierbare Oligonukleotidsynthese |
| US8932994B2 (en) | 2006-08-24 | 2015-01-13 | Illumina, Inc. | Method for retaining even coverage of short insert libraries |
| US8053191B2 (en) | 2006-08-31 | 2011-11-08 | Westend Asset Clearinghouse Company, Llc | Iterative nucleic acid assembly using activation of vector-encoded traits |
| US8415138B2 (en) | 2006-08-31 | 2013-04-09 | Agilent Technologies, Inc. | Apparatuses and methods for oligonucleotide preparation |
| US8097711B2 (en) | 2006-09-02 | 2012-01-17 | Agilent Technologies, Inc. | Thioether substituted aryl carbonate protecting groups |
| US20080311628A1 (en) | 2006-10-03 | 2008-12-18 | Ghc Technologies, Inc. | Methods and compositions for rapid amplification and capture of nucleic acid sequences |
| WO2008045380A2 (en) | 2006-10-04 | 2008-04-17 | Codon Devices, Inc. | Nucleic acid libraries and their design and assembly |
| US20080085511A1 (en) | 2006-10-05 | 2008-04-10 | Peck Bill J | Preparation of biopolymer arrays |
| US20080085514A1 (en) | 2006-10-10 | 2008-04-10 | Peck Bill J | Methods and devices for array synthesis |
| JP2008097189A (ja) | 2006-10-10 | 2008-04-24 | National Institute Of Advanced Industrial & Technology | 塩基配列断片の転写物特異性又は遺伝子特異性を判定する方法 |
| US7867782B2 (en) | 2006-10-19 | 2011-01-11 | Agilent Technologies, Inc. | Nanoscale moiety placement methods |
| US7999087B2 (en) | 2006-11-15 | 2011-08-16 | Agilent Technologies, Inc. | 2′-silyl containing thiocarbonate protecting groups for RNA synthesis |
| WO2008063134A1 (en) | 2006-11-24 | 2008-05-29 | Agency For Science, Technology And Research | Method of producing a pattern of discriminative wettability |
| WO2008063135A1 (en) | 2006-11-24 | 2008-05-29 | Agency For Science, Technology And Research | Apparatus for processing a sample in a liquid droplet and method of using the same |
| US8242258B2 (en) | 2006-12-03 | 2012-08-14 | Agilent Technologies, Inc. | Protecting groups for RNA synthesis |
| US7989396B2 (en) | 2006-12-05 | 2011-08-02 | The Board Of Trustees Of The Leland Stanford Junior University | Biomolecule immobilization on biosensors |
| JP2010511397A (ja) | 2006-12-05 | 2010-04-15 | アブリンクス エン．ヴェー． | 血清タンパク質と結合可能なペプチド |
| US7862999B2 (en) | 2007-01-17 | 2011-01-04 | Affymetrix, Inc. | Multiplex targeted amplification using flap nuclease |
| US8314220B2 (en) | 2007-01-26 | 2012-11-20 | Agilent Technologies, Inc. | Methods compositions, and kits for detection of microRNA |
| US20080182296A1 (en) | 2007-01-31 | 2008-07-31 | Chanda Pranab K | Pcr-directed gene synthesis from large number of overlapping oligodeoxyribonucleotides |
| KR100827449B1 (ko) | 2007-02-07 | 2008-05-07 | 삼성전자주식회사 | 광분해성 화합물과 상기 화합물이 커플링된 올리고머프로브 어레이용 기판, 올리고머 프로브 어레이 및 이의제조 방법 |
| US20100323404A1 (en) | 2007-02-09 | 2010-12-23 | Richard Lathrop | Method for recombining dna sequences and compositions related thereto |
| JP5675109B2 (ja) | 2007-02-20 | 2015-02-25 | アナプティスバイオ インコーポレイティッド | ライブラリーの生成方法及びその使用 |
| WO2008109176A2 (en) | 2007-03-07 | 2008-09-12 | President And Fellows Of Harvard College | Assays and other reactions involving droplets |
| US7651762B2 (en) | 2007-03-13 | 2010-01-26 | Varian, Inc. | Methods and devices using a shrinkable support for porous monolithic materials |
| WO2008124107A1 (en) | 2007-04-04 | 2008-10-16 | The Regents Of The University Of California | Compositions, devices, systems, and methods for using a nanopore |
| PL2476689T3 (pl) | 2007-05-10 | 2016-04-29 | Agilent Technologies Inc | Tiowęglowe grupy zabezpieczające do syntezy RNA |
| WO2008148392A1 (en) | 2007-06-04 | 2008-12-11 | In Situ Rcp A/S | Enzyme activity assay using rolling circle amplification |
| US20090023190A1 (en) | 2007-06-20 | 2009-01-22 | Kai Qin Lao | Sequence amplification with loopable primers |
| US20080318334A1 (en) | 2007-06-20 | 2008-12-25 | Robotti Karla M | Microfluidic devices comprising fluid flow paths having a monolithic chromatographic material |
| US8194244B2 (en) | 2007-06-29 | 2012-06-05 | Intel Corporation | Solution sample plate with wells designed for improved Raman scattering signal detection efficiency |
| US7659069B2 (en) | 2007-08-31 | 2010-02-09 | Agilent Technologies, Inc. | Binary signaling assay using a split-polymerase |
| US8685642B2 (en) | 2007-07-30 | 2014-04-01 | Agilent Technologies, Inc. | Allele-specific copy number measurement using single nucleotide polymorphism and DNA arrays |
| US7979215B2 (en) | 2007-07-30 | 2011-07-12 | Agilent Technologies, Inc. | Methods and systems for evaluating CGH candidate probe nucleic acid sequences |
| US20090036664A1 (en) | 2007-07-31 | 2009-02-05 | Brian Jon Peter | Complex oligonucleotide primer mix |
| US20110124049A1 (en) | 2007-08-07 | 2011-05-26 | Mo-Huang Li | Integrated microfluidic device for gene synthesis |
| US9440231B2 (en) | 2007-08-14 | 2016-09-13 | Fluidigm Corporation | Polymer microfluidic biochip fabrication |
| US20110126929A1 (en) | 2007-08-15 | 2011-06-02 | Massachusetts Institute Of Technology | Microstructures For Fluidic Ballasting and Flow Control |
| US9598737B2 (en) | 2012-05-09 | 2017-03-21 | Longhorn Vaccines And Diagnostics, Llc | Next generation genomic sequencing methods |
| US20090053704A1 (en) | 2007-08-24 | 2009-02-26 | Natalia Novoradovskaya | Stabilization of nucleic acids on solid supports |
| US8877688B2 (en) | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
| EP2198000A4 (en) | 2007-09-17 | 2013-02-20 | SUPRAMOLECULAR NANO-STAMP PRINTING DEVICE | |
| US7790387B2 (en) | 2007-09-24 | 2010-09-07 | Agilent Technologies, Inc. | Thiocarbonate linkers for polynucleotides |
| EP2203566A4 (en) | 2007-09-28 | 2011-02-09 | Pacific Biosciences California | ERROR-FREE DNA AMPLIFICATION FOR CLONAL SEQUENCING |
| EP2053132A1 (en) | 2007-10-23 | 2009-04-29 | Roche Diagnostics GmbH | Enrichment and sequence analysis of geomic regions |
| WO2009070665A1 (en) | 2007-11-27 | 2009-06-04 | Massachusetts Institute Of Technology | Near field detector for integrated surface plasmon resonance biosensor applications |
| US20100272711A1 (en) | 2007-12-12 | 2010-10-28 | Thomas Jefferson University | Compositions and methods for the treatment and prevention of cardiovascular diseases |
| EP2247708A4 (en) | 2007-12-17 | 2013-02-27 | Yeda Res & Dev | SYSTEM AND METHOD FOR PROCESSING AND MANIPULATING DNA |
| US9540637B2 (en) | 2008-01-09 | 2017-01-10 | Life Technologies Corporation | Nucleic acid adaptors and uses thereof |
| WO2009089384A1 (en) | 2008-01-09 | 2009-07-16 | Life Technologies | Method of making a paired tag library for nucleic acid sequencing |
| US7682809B2 (en) | 2008-01-11 | 2010-03-23 | Agilent Technologies, Inc. | Direct ATP release sequencing |
| EP2238459B1 (en) | 2008-01-23 | 2019-05-08 | Roche Diagnostics GmbH | Integrated instrument performing synthesis and amplification |
| US8304273B2 (en) | 2008-01-24 | 2012-11-06 | Massachusetts Institute Of Technology | Insulated nanogap devices and methods of use thereof |
| WO2009097368A2 (en) | 2008-01-28 | 2009-08-06 | Complete Genomics, Inc. | Methods and compositions for efficient base calling in sequencing reactions |
| US20090194483A1 (en) | 2008-01-31 | 2009-08-06 | Robotti Karla M | Microfluidic device having monolithic separation medium and method of use |
| EP3064599B1 (en) | 2008-02-15 | 2018-12-12 | Synthetic Genomics, Inc. | Methods for in vitro joining and combinatorial assembly of nucleic acid molecules |
| WO2009113709A1 (ja) | 2008-03-11 | 2009-09-17 | 国立大学法人東京大学 | 粘着末端を有するｄｎａ断片の調製方法 |
| US20090230044A1 (en) | 2008-03-13 | 2009-09-17 | Agilent Technologies, Inc. | Microfluid Chip Cleaning |
| US20090238722A1 (en) | 2008-03-18 | 2009-09-24 | Agilent Technologies, Inc. | Pressure-Reinforced Fluidic Chip |
| US8906831B2 (en) | 2008-03-31 | 2014-12-09 | Pacific Biosciences Of California, Inc. | Single molecule loading methods and compositions |
| US20090246788A1 (en) | 2008-04-01 | 2009-10-01 | Roche Nimblegen, Inc. | Methods and Assays for Capture of Nucleic Acids |
| US8911948B2 (en) | 2008-04-30 | 2014-12-16 | Integrated Dna Technologies, Inc. | RNase H-based assays utilizing modified RNA monomers |
| EP2113255A1 (en) | 2008-05-02 | 2009-11-04 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Cytotoxic immunoglobulin |
| JP4582224B2 (ja) | 2008-05-02 | 2010-11-17 | ソニー株式会社 | マイクロビーズ作製方法及びマイクロビーズ |
| JP5588970B2 (ja) | 2008-05-27 | 2014-09-10 | ダコ・デンマーク・エー／エス | ハイブリダイゼーション組成物及び方法 |
| JP5654986B2 (ja) | 2008-06-30 | 2015-01-14 | モーフオテク・インコーポレーテツド | 抗ｇｄ２抗体並びにそれに関連する方法及び使用 |
| GB2461546B (en) | 2008-07-02 | 2010-07-07 | Argen X Bv | Antigen binding polypeptides |
| JP4667490B2 (ja) | 2008-07-09 | 2011-04-13 | 三菱電機株式会社 | 加熱調理器 |
| WO2010014903A1 (en) | 2008-07-31 | 2010-02-04 | Massachusetts Institute Of Technology | Multiplexed olfactory receptor-based microsurface plasmon polariton detector |
| WO2010021936A1 (en) | 2008-08-16 | 2010-02-25 | The Board Of Trustees Of The Leland Stanford Junior University | Digital pcr calibration for high throughput sequencing |
| JP5908725B2 (ja) | 2008-08-22 | 2016-04-26 | サンガモ バイオサイエンシーズ， インコーポレイテッド | 標的一本鎖開裂および標的組込みのための方法、並びに組成物 |
| WO2010025310A2 (en) | 2008-08-27 | 2010-03-04 | Westend Asset Clearinghouse Company, Llc | Methods and devices for high fidelity polynucleotide synthesis |
| US8034917B2 (en) | 2008-08-28 | 2011-10-11 | Agilent Technologies, Inc. | Primer-directed chromosome painting |
| CN102639552B (zh) | 2008-09-05 | 2016-05-25 | 高端学术皇家研究会/麦吉尔大学 | 含有O-缩醛乙酰丙酸酯基团(O-acetal levulinyl ester)的RNA单体及其在RNA微阵列中的应用 |
| US20100129810A1 (en) | 2008-09-05 | 2010-05-27 | Life Technologies Corporation | Methods and systems for nucleic acid sequencing validation, calibration and normalization |
| US8586310B2 (en) | 2008-09-05 | 2013-11-19 | Washington University | Method for multiplexed nucleic acid patch polymerase chain reaction |
| US8541569B2 (en) | 2008-09-06 | 2013-09-24 | Chemgenes Corporation | Phosphoramidites for synthetic RNA in the reverse direction, efficient RNA synthesis and convenient introduction of 3'-end ligands, chromophores and modifications of synthetic RNA |
| CN102439025B (zh) | 2008-09-06 | 2017-08-01 | 坎姆根公司 | Rna合成－用于反向合成rna的亚磷酰胺，以及在3’‑末端合成rna的配体、发色团和修饰物的方便引入中的应用 |
| WO2010030776A1 (en) | 2008-09-10 | 2010-03-18 | Genscript Corporation | Homologous recombination-based dna cloning methods and compositions |
| US20100076183A1 (en) | 2008-09-22 | 2010-03-25 | Dellinger Douglas J | Protected monomer and method of final deprotection for rna synthesis |
| US8213015B2 (en) | 2008-09-25 | 2012-07-03 | Agilent Technologies, Inc. | Integrated flow cell with semiconductor oxide tubing |
| RU2011117213A (ru) | 2008-09-30 | 2012-11-10 | Эббот Лэборетриз (Us) | Улучшенные библиотеки антител |
| US20100090341A1 (en) | 2008-10-14 | 2010-04-15 | Molecular Imprints, Inc. | Nano-patterned active layers formed by nano-imprint lithography |
| US20100301398A1 (en) | 2009-05-29 | 2010-12-02 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
| US9080211B2 (en) | 2008-10-24 | 2015-07-14 | Epicentre Technologies Corporation | Transposon end compositions and methods for modifying nucleic acids |
| US8357489B2 (en) | 2008-11-13 | 2013-01-22 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for detecting hepatocellular carcinoma |
| US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
| BRPI0923225A2 (pt) | 2008-12-02 | 2016-10-04 | Chiralgen Ltd | metodo para sintese de acidos nucleicos modificados no atomo de fosforo |
| US8963262B2 (en) | 2009-08-07 | 2015-02-24 | Massachusettes Institute Of Technology | Method and apparatus for forming MEMS device |
| JO3382B1 (ar) | 2008-12-23 | 2019-03-13 | Amgen Inc | أجسام مضادة ترتبط مع مستقبل cgrp بشري |
| TW201104253A (en) | 2008-12-31 | 2011-02-01 | Nat Health Research Institutes | Microarray chip and method of fabricating for the same |
| WO2010089412A1 (en) | 2009-02-09 | 2010-08-12 | Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt (Gmbh) | Repertoire of allo-restricted peptide-specific t cell receptor sequences and use thereof |
| EP2398915B1 (en) | 2009-02-20 | 2016-08-24 | Synthetic Genomics, Inc. | Synthesis of sequence-verified nucleic acids |
| US8569046B2 (en) | 2009-02-20 | 2013-10-29 | Massachusetts Institute Of Technology | Microarray with microchannels |
| MX355507B (es) | 2009-03-09 | 2018-04-19 | Bioatla Llc | Proteinas mirac. |
| WO2010115122A2 (en) | 2009-04-03 | 2010-10-07 | Illumina, Inc. | Generation of uniform fragments of nucleic acids using patterned substrates |
| US7862716B2 (en) | 2009-04-13 | 2011-01-04 | Sielc Technologies Corporation | HPLC schematic with integrated sample cleaning system |
| CN102802798B (zh) | 2009-04-29 | 2015-04-08 | 锡克拜控股有限公司 | 用于将生物液体淀积在基板上的方法和仪器 |
| US9085798B2 (en) | 2009-04-30 | 2015-07-21 | Prognosys Biosciences, Inc. | Nucleic acid constructs and methods of use |
| EP2248914A1 (en) | 2009-05-05 | 2010-11-10 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | The use of class IIB restriction endonucleases in 2nd generation sequencing applications |
| US20120156728A1 (en) | 2010-12-17 | 2012-06-21 | Life Technologies Corporation | Clonal amplification of nucleic acid on solid surface with template walking |
| US9309557B2 (en) | 2010-12-17 | 2016-04-12 | Life Technologies Corporation | Nucleic acid amplification |
| US20100292102A1 (en) | 2009-05-14 | 2010-11-18 | Ali Nouri | System and Method For Preventing Synthesis of Dangerous Biological Sequences |
| US20100300882A1 (en) | 2009-05-26 | 2010-12-02 | General Electric Company | Devices and methods for in-line sample preparation of materials |
| ES2532891T3 (es) | 2009-06-02 | 2015-04-01 | The Regents Of The University Of California | Descubrimiento de virus mediante secuenciación y ensamblaje de ARNip, miARN, ARNpi derivados de virus |
| WO2010141249A2 (en) | 2009-06-02 | 2010-12-09 | Merck Sharp & Dohme Corp. | Generation, characterization and uses thereof of anti-notch3 antibodies |
| US8309710B2 (en) | 2009-06-29 | 2012-11-13 | Agilent Technologies, Inc. | Use of N-alkyl imidazole for sulfurization of oligonucleotides with an acetyl disulfide |
| US8642755B2 (en) | 2009-06-30 | 2014-02-04 | Agilent Technologies, Inc. | Use of thioacetic acid derivatives in the sulfurization of oligonucleotides with phenylacetyl disulfide |
| GB0912909D0 (en) | 2009-07-23 | 2009-08-26 | Olink Genomics Ab | Probes for specific analysis of nucleic acids |
| US8329208B2 (en) | 2009-07-28 | 2012-12-11 | Methylation Sciences International Srl | Pharmacokinetics of S-adenosylmethionine formulations |
| WO2011012280A1 (en) | 2009-07-30 | 2011-02-03 | Roche Diagnostics Gmbh | A set of oligonucleotide probes as well as methods and uses related thereto |
| BR112012003686B1 (pt) | 2009-08-19 | 2021-09-21 | Merck Patent Gmbh | Anticorpos monoclonais, seu uso para detecção de complexos de integrina em material ffpe, e polinucleotídeo |
| ES2562159T3 (es) | 2009-08-20 | 2016-03-02 | Population Genetics Technologies Ltd. | Composiciones y métodos para el reordenamiento de ácido nucleico molecular |
| US8476598B1 (en) | 2009-08-31 | 2013-07-02 | Sionyx, Inc. | Electromagnetic radiation imaging devices and associated methods |
| US20110082055A1 (en) | 2009-09-18 | 2011-04-07 | Codexis, Inc. | Reduced codon mutagenesis |
| US20120184724A1 (en) | 2009-09-22 | 2012-07-19 | Agilent Technologies, Inc. | Protected monomers and methods of deprotection for rna synthesis |
| WO2011038241A1 (en) | 2009-09-25 | 2011-03-31 | President And Fellows Of Harvard College | Nucleic acid amplification and sequencing by synthesis with fluorogenic nucleotides |
| US8975019B2 (en) | 2009-10-19 | 2015-03-10 | University Of Massachusetts | Deducing exon connectivity by RNA-templated DNA ligation/sequencing |
| JP5774595B2 (ja) | 2009-10-28 | 2015-09-09 | ヤンセン バイオテツク，インコーポレーテツド | 抗ｇｌｐ−１ｒ抗体及びそれらの使用 |
| WO2011053957A2 (en) | 2009-11-02 | 2011-05-05 | Gen9, Inc. | Compositions and methods for the regulation of multiple genes of interest in a cell |
| WO2011056872A2 (en) | 2009-11-03 | 2011-05-12 | Gen9, Inc. | Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly |
| US20110114549A1 (en) | 2009-11-13 | 2011-05-19 | Agilent Technolgies, Inc. | Microfluidic device comprising separation columns |
| EP2504449B1 (en) | 2009-11-25 | 2016-03-23 | Gen9, Inc. | Methods and apparatuses for chip-based dna error reduction |
| WO2011066185A1 (en) | 2009-11-25 | 2011-06-03 | Gen9, Inc. | Microfluidic devices and methods for gene synthesis |
| WO2011068186A1 (ja) | 2009-12-03 | 2011-06-09 | 日本電気株式会社 | パケット受信装置、パケット通信システム、パケット順序制御方法 |
| US8500979B2 (en) | 2009-12-31 | 2013-08-06 | Intel Corporation | Nanogap chemical and biochemical sensors |
| WO2011085075A2 (en) | 2010-01-07 | 2011-07-14 | Gen9, Inc. | Assembly of high fidelity polynucleotides |
| US9758817B2 (en) | 2010-01-13 | 2017-09-12 | Agilent Technologies, Inc. | Method for identifying a nucleic acid in a sample |
| KR101230350B1 (ko) | 2010-01-27 | 2013-02-06 | 주식회사 엘지화학 | 구조적 안정성이 우수한 전지팩 |
| KR20110094878A (ko) | 2010-02-18 | 2011-08-24 | 삼성전자주식회사 | 올리고머 어레이 제조용 조성물 및 올리고머 어레이 제조 방법 |
| GB201003036D0 (en) | 2010-02-23 | 2010-04-07 | Fermentas Uab | Restriction endonucleases and their applications |
| US20120027786A1 (en) | 2010-02-23 | 2012-02-02 | Massachusetts Institute Of Technology | Genetically programmable pathogen sense and destroy |
| US8716467B2 (en) | 2010-03-03 | 2014-05-06 | Gen9, Inc. | Methods and devices for nucleic acid synthesis |
| CN102939380A (zh) | 2010-03-05 | 2013-02-20 | 合成基因组股份有限公司 | 用于克隆和操作基因组的方法 |
| EP2703491B1 (en) | 2010-04-09 | 2017-03-08 | The Catholic University Of America | Protein and nucleic acid delivery vehicles, components and mechanisms thereof |
| US10240194B2 (en) | 2010-05-13 | 2019-03-26 | Gen9, Inc. | Methods for nucleotide sequencing and high fidelity polynucleotide synthesis |
| WO2011150168A1 (en) | 2010-05-28 | 2011-12-01 | Gen9, Inc. | Methods and devices for in situ nucleic acid synthesis |
| GB2481425A (en) | 2010-06-23 | 2011-12-28 | Iti Scotland Ltd | Method and device for assembling polynucleic acid sequences |
| JP2013535199A (ja) | 2010-07-28 | 2013-09-12 | イムノコア リミテッド | Ｔ細胞レセプター |
| EP2619327B1 (en) | 2010-09-21 | 2014-10-22 | Population Genetics Technologies LTD. | Increasing confidence of allele calls with molecular counting |
| US8715933B2 (en) | 2010-09-27 | 2014-05-06 | Nabsys, Inc. | Assay methods using nicking endonucleases |
| WO2012045001A2 (en) | 2010-09-30 | 2012-04-05 | Vanderbilt University | Influenza virus antibodies and immunogens and uses therefor |
| US9689012B2 (en) | 2010-10-12 | 2017-06-27 | Cornell University | Method of dual-adapter recombination for efficient concatenation of multiple DNA fragments in shuffled or specified arrangements |
| EP2630264A4 (en) | 2010-10-22 | 2014-04-02 | Harvard College | Orthogonal amplification and assembly of nucleic acid sequences |
| CA2821299C (en) | 2010-11-05 | 2019-02-12 | Frank J. Steemers | Linking sequence reads using paired code tags |
| WO2012064975A1 (en) | 2010-11-12 | 2012-05-18 | Gen9, Inc. | Protein arrays and methods of using and making the same |
| CA2817697C (en) | 2010-11-12 | 2021-11-16 | Gen9, Inc. | Methods and devices for nucleic acids synthesis |
| US20120164633A1 (en) | 2010-12-27 | 2012-06-28 | Ibis Biosciences, Inc. | Digital droplet sequencing |
| WO2012092260A1 (en) | 2010-12-27 | 2012-07-05 | Ibis Biosciences, Inc. | Compositions and methods for producing single-stranded circular dna |
| WO2012092374A2 (en) | 2010-12-31 | 2012-07-05 | Short Jay M | Express humanization of antibodies |
| CN104673670A (zh) | 2011-03-30 | 2015-06-03 | 独立行政法人国立长寿医疗研究中心 | 膜分选培养器、膜分选培养试剂盒、和使用其的干细胞分选方法、以及分离膜 |
| US10131903B2 (en) | 2011-04-01 | 2018-11-20 | The Regents Of The University Of California | Microfluidic platform for synthetic biology applications |
| US9384920B1 (en) | 2011-04-04 | 2016-07-05 | Eric J. Bakulich | Locking knob |
| US20140357497A1 (en) | 2011-04-27 | 2014-12-04 | Kun Zhang | Designing padlock probes for targeted genomic sequencing |
| US8722585B2 (en) | 2011-05-08 | 2014-05-13 | Yan Wang | Methods of making di-tagged DNA libraries from DNA or RNA using double-tagged oligonucleotides |
| SG10201605049QA (en) | 2011-05-20 | 2016-07-28 | Fluidigm Corp | Nucleic acid encoding reactions |
| US9752176B2 (en) | 2011-06-15 | 2017-09-05 | Ginkgo Bioworks, Inc. | Methods for preparative in vitro cloning |
| US9695227B2 (en) | 2011-06-21 | 2017-07-04 | Vrije Universiteit Brussel | Binding domains directed against GPCR:G protein complexes and uses derived thereof |
| WO2013003630A2 (en) | 2011-06-28 | 2013-01-03 | Igor Kutyavin | Methods and compositions for enrichment of nucleic acids in mixtures of highly homologous sequences |
| US20130045483A1 (en) | 2011-07-01 | 2013-02-21 | Whitehead Institute For Biomedical Research | Yeast cells expressing amyloid beta and uses therefor |
| WO2013019361A1 (en) | 2011-07-07 | 2013-02-07 | Life Technologies Corporation | Sequencing methods |
| US20130017978A1 (en) | 2011-07-11 | 2013-01-17 | Finnzymes Oy | Methods and transposon nucleic acids for generating a dna library |
| WO2013010062A2 (en) | 2011-07-14 | 2013-01-17 | Life Technologies Corporation | Nucleic acid complexity reduction |
| WO2013023220A2 (en) * | 2011-08-11 | 2013-02-14 | Life Technologies Corporation | Systems and methods for nucleic acid-based identification |
| US20150203839A1 (en) | 2011-08-26 | 2015-07-23 | Gen9, Inc. | Compositions and Methods for High Fidelity Assembly of Nucleic Acids |
| JP2014526899A (ja) | 2011-08-26 | 2014-10-09 | ジェン９・インコーポレイテッド | 核酸の高忠実度アセンブリのための組成物および方法 |
| EP2751729B1 (en) | 2011-09-01 | 2020-10-21 | Genome Compiler Corporation | System for polynucleotide construct design, visualization and transactions to manufacture the same |
| WO2013036668A1 (en) | 2011-09-06 | 2013-03-14 | Gen-Probe Incorporated | Circularized templates for sequencing |
| US8840981B2 (en) | 2011-09-09 | 2014-09-23 | Eastman Kodak Company | Microfluidic device with multilayer coating |
| LT2768607T (lt) | 2011-09-26 | 2021-12-27 | Thermo Fisher Scientific Geneart Gmbh | Daugiašulininė plokštelė didelio efektyvumo, mažo tūrio nukleorūgščių sintezei atlikti |
| EP2766838A2 (en) | 2011-10-11 | 2014-08-20 | Life Technologies Corporation | Systems and methods for analysis and interpretation of nucleic acid sequence data |
| EP2769007B1 (en) | 2011-10-19 | 2016-12-07 | Nugen Technologies, Inc. | Compositions and methods for directional nucleic acid amplification and sequencing |
| US8987174B2 (en) | 2011-10-28 | 2015-03-24 | Prognosys Biosciences, Inc. | Methods for manufacturing molecular arrays |
| US8815782B2 (en) | 2011-11-11 | 2014-08-26 | Agilent Technologies, Inc. | Use of DNAzymes for analysis of an RNA sample |
| US8450107B1 (en) | 2011-11-30 | 2013-05-28 | The Broad Institute Inc. | Nucleotide-specific recognition sequences for designer TAL effectors |
| EP2599785A1 (en) | 2011-11-30 | 2013-06-05 | Agilent Technologies, Inc. | Novel methods for the synthesis and purification of oligomers |
| US20130137173A1 (en) | 2011-11-30 | 2013-05-30 | Feng Zhang | Nucleotide-specific recognition sequences for designer tal effectors |
| WO2013096692A1 (en) | 2011-12-21 | 2013-06-27 | Illumina, Inc. | Apparatus and methods for kinetic analysis and determination of nucleic acid sequences |
| WO2013093693A1 (en) | 2011-12-22 | 2013-06-27 | Rinat Neuroscience Corp. | Staphylococcus aureus specific antibodies and uses thereof |
| WO2013101896A1 (en) | 2011-12-30 | 2013-07-04 | Quest Diagnostics Investments Incorporated | Nucleic acid analysis using emulsion pcr |
| CA2862149C (en) | 2012-02-01 | 2022-07-26 | Synthetic Genomics, Inc. | Materials and methods for the synthesis of error-minimized nucleic acid molecules |
| WO2013130512A2 (en) | 2012-02-27 | 2013-09-06 | The University Of North Carolina At Chapel Hill | Methods and uses for molecular tags |
| EP3287531B1 (en) | 2012-02-28 | 2019-06-19 | Agilent Technologies, Inc. | Method for attaching a counter sequence to a nucleic acid sample |
| EP2825653A4 (en) | 2012-03-14 | 2016-01-20 | Innovative Targeting Solutions Inc | PRODUCTION OF TARGETED SEQUENCE DIVERSITY IN FUSION PROTEINS |
| US9150853B2 (en) | 2012-03-21 | 2015-10-06 | Gen9, Inc. | Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis |
| AU2013237989B2 (en) | 2012-03-28 | 2017-07-20 | 3M Innovative Properties Company | Reduced-pressure systems, dressings, and methods facilitating separation of electronic and clinical component parts |
| US9732384B2 (en) | 2012-04-02 | 2017-08-15 | Lux Bio Group, Inc. | Apparatus and method for molecular separation, purification, and sensing |
| AU2013246359B2 (en) | 2012-04-10 | 2017-03-30 | The Trustees Of Princeton University | Ultra-sensitive sensor |
| US20150353921A9 (en) | 2012-04-16 | 2015-12-10 | Jingdong Tian | Method of on-chip nucleic acid molecule synthesis |
| CA2871505C (en) | 2012-04-24 | 2021-10-12 | Gen9, Inc. | Methods for sorting nucleic acids and multiplexed preparative in vitro cloning |
| US20130281308A1 (en) | 2012-04-24 | 2013-10-24 | Gen9, Inc. | Methods for sorting nucleic acids and preparative in vitro cloning |
| EP3553089A1 (en) | 2012-05-10 | 2019-10-16 | Bioatla, LLC | Multi-specific monoclonal antibodies |
| WO2013177220A1 (en) | 2012-05-21 | 2013-11-28 | The Scripps Research Institute | Methods of sample preparation |
| US10308979B2 (en) | 2012-06-01 | 2019-06-04 | Agilent Technologies, Inc. | Target enrichment and labeling for multi-kilobase DNA |
| WO2013178801A2 (en) | 2012-06-01 | 2013-12-05 | European Molecular Biology Laboratory | High-capacity storage of digital information in dna |
| WO2013188037A2 (en) | 2012-06-11 | 2013-12-19 | Agilent Technologies, Inc | Method of adaptor-dimer subtraction using a crispr cas6 protein |
| WO2014004393A1 (en) | 2012-06-25 | 2014-01-03 | Gen9, Inc. | Methods for nucleic acid assembly and high throughput sequencing |
| JP6433893B2 (ja) | 2012-07-03 | 2018-12-05 | インテグレイテツド・デイー・エヌ・エイ・テクノロジーズ・インコーポレイテツド | Ｔｍ増強ブロッキングオリゴヌクレオチド、ならびに標的濃縮の改善およびオフターゲット選択の低減のためのベイト |
| US9255245B2 (en) | 2012-07-03 | 2016-02-09 | Agilent Technologies, Inc. | Sample probes and methods for sampling intracellular material |
| US20140038240A1 (en) | 2012-07-10 | 2014-02-06 | Pivot Bio, Inc. | Methods for multipart, modular and scarless assembly of dna molecules |
| WO2014012071A1 (en) | 2012-07-12 | 2014-01-16 | Massachusetts Institute Of Technology | Methods and apparatus for assembly |
| JP6239813B2 (ja) | 2012-07-18 | 2017-11-29 | 株式会社Ｓｃｒｅｅｎセミコンダクターソリューションズ | 基板処理装置および基板処理方法 |
| CA2878042C (en) | 2012-07-19 | 2017-11-28 | President And Fellows Of Harvard College | Methods of storing information using nucleic acids |
| NZ741124A (en) | 2012-07-27 | 2019-11-29 | Univ Illinois | Engineering t-cell receptors |
| WO2014021938A1 (en) | 2012-08-02 | 2014-02-06 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and apparatus for nucleic acid synthesis using oligo-templated polymerization |
| JP6510407B2 (ja) | 2012-08-16 | 2019-05-08 | シンセティック ジェノミクス インコーポレーテッド | デジタル生物学的コンバータ |
| EP2890836B1 (en) | 2012-08-31 | 2019-07-17 | The Scripps Research Institute | Methods related to modulators of eukaryotic cells |
| WO2014039587A1 (en) | 2012-09-05 | 2014-03-13 | Bio-Rad Laboratories, Inc. | Systems and methods for stabilizing droplets |
| WO2014062717A1 (en) | 2012-10-15 | 2014-04-24 | Life Technologies Corporation | Compositions, methods, systems and kits for target nucleic acid enrichment |
| KR20140048733A (ko) | 2012-10-16 | 2014-04-24 | 삼성전자주식회사 | 다중 웰 플레이트 및 상기 다중 웰 플레이트를 이용한 표적 물질 분석 방법 |
| EP2912197B1 (en) | 2012-10-24 | 2019-08-07 | Takara Bio USA, Inc. | Template switch-based methods for producing a product nucleic acid |
| CA2932532C (en) | 2012-12-04 | 2021-06-22 | Phosphorex, Inc. | Microparticles and nanoparticles having negative surface charges |
| EP2929048B1 (en) | 2012-12-06 | 2017-12-13 | Agilent Technologies, Inc. | Restriction enzyme-free target enrichment |
| EP2929027B1 (en) | 2012-12-06 | 2018-02-21 | Agilent Technologies, Inc. | Molecular fabrication |
| US9976162B2 (en) | 2012-12-10 | 2018-05-22 | Agilent Technologies, Inc. | Pairing code directed assembly |
| CN105531375B (zh) | 2012-12-10 | 2020-03-03 | 分析生物科学有限公司 | 靶向基因组分析的方法 |
| WO2014093694A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Crispr-cas nickase systems, methods and compositions for sequence manipulation in eukaryotes |
| SG11201506750QA (en) | 2013-02-28 | 2015-09-29 | Univ Nanyang Tech | Method of manufacturing a device for supporting biological material growth and device therefrom |
| EP2964778B1 (en) | 2013-03-05 | 2019-10-09 | Agilent Technologies, Inc. | Detection of genomic rearrangements by sequence capture |
| US9580746B2 (en) | 2013-03-05 | 2017-02-28 | Agilent Technologies, Inc. | Synthesis of long fish probes |
| US10280417B2 (en) | 2013-03-13 | 2019-05-07 | Gen 9, Inc. | Compositions, methods and apparatus for oligonucleotides synthesis |
| WO2014160059A1 (en) | 2013-03-13 | 2014-10-02 | Gen9, Inc. | Compositions and methods for synthesis of high fidelity oligonucleotides |
| US20160032396A1 (en) | 2013-03-15 | 2016-02-04 | The Board Of Trustees Of The Leland Stanford Junior University | Identification and Use of Circulating Nucleic Acid Tumor Markers |
| US20140274741A1 (en) | 2013-03-15 | 2014-09-18 | The Translational Genomics Research Institute | Methods to capture and sequence large fragments of dna and diagnostic methods for neuromuscular disease |
| BR112015021521A2 (pt) | 2013-03-15 | 2017-10-10 | Genentech Inc | anticorpos anti-crth2 e métodos para seu uso |
| CN105209475B (zh) | 2013-03-15 | 2018-06-12 | Gen9股份有限公司 | 多重核酸合成的组合物和方法 |
| US20140274729A1 (en) | 2013-03-15 | 2014-09-18 | Nugen Technologies, Inc. | Methods, compositions and kits for generation of stranded rna or dna libraries |
| US9279149B2 (en) | 2013-04-02 | 2016-03-08 | Molecular Assemblies, Inc. | Methods and apparatus for synthesizing nucleic acids |
| US9771613B2 (en) | 2013-04-02 | 2017-09-26 | Molecular Assemblies, Inc. | Methods and apparatus for synthesizing nucleic acid |
| US10683536B2 (en) | 2013-04-02 | 2020-06-16 | Molecular Assemblies, Inc. | Reusable initiators for synthesizing nucleic acids |
| US20150293102A1 (en) | 2013-04-13 | 2015-10-15 | Jung-Uk Shim | Detecting low-abundant analyte in microfluidic droplets |
| ITRM20130278A1 (it) | 2013-05-10 | 2014-11-11 | Consiglio Nazionale Ricerche | Procedimento di fabbricazione di film autoassemblati di copolimeri a blocchi |
| JP6549564B2 (ja) | 2013-06-26 | 2019-07-24 | グアンドン シャンスエ ライフ サイエンス， リミテッド． | 高安定性のｔ細胞受容体およびその製法と使用 |
| US20150010953A1 (en) | 2013-07-03 | 2015-01-08 | Agilent Technologies, Inc. | Method for producing a population of oligonucleotides that has reduced synthesis errors |
| KR20150005062A (ko) | 2013-07-04 | 2015-01-14 | 삼성전자주식회사 | 미니-코어를 사용하는 프로세서 |
| US10421957B2 (en) | 2013-07-29 | 2019-09-24 | Agilent Technologies, Inc. | DNA assembly using an RNA-programmable nickase |
| US11475980B2 (en) | 2013-07-29 | 2022-10-18 | Battelle Memorial Institute | Methods of analyzing massively parallel sequencing data |
| EP3027771B1 (en) | 2013-07-30 | 2019-01-16 | Gen9, Inc. | Methods for the production of long length clonal sequence verified nucleic acid constructs |
| KR102160389B1 (ko) | 2013-08-05 | 2020-09-28 | 트위스트 바이오사이언스 코포레이션 | 드 노보 합성된 유전자 라이브러리 |
| US9595180B2 (en) | 2013-08-07 | 2017-03-14 | Nike, Inc. | Activity recognition with activity reminders |
| CN104371019B (zh) | 2013-08-13 | 2019-09-10 | 鸿运华宁（杭州）生物医药有限公司 | 一种能与glp-1r特异性结合的抗体及其与glp-1的融合蛋白质 |
| GB201314721D0 (en) | 2013-08-16 | 2013-10-02 | Almagen Ltd | A method of selectively masking one or more sites on a surface and a method of synthesising an array of molecules |
| GB2534067B (en) | 2013-08-30 | 2021-07-21 | Personalis Inc | Methods and systems for genomic analysis |
| EP3044228B1 (en) | 2013-09-14 | 2021-04-07 | Chemgenes Corporation | Highly efficient synthesis of long rna using reverse direction approach |
| WO2015040075A1 (en) | 2013-09-18 | 2015-03-26 | Genome Research Limited | Genomic screening methods using rna-guided endonucleases |
| US9422325B2 (en) | 2013-10-04 | 2016-08-23 | Trustees Of Tufts College | Glycosylation reactions using phenyl(trifluoroethyl)iodonium salts |
| CN105745528A (zh) | 2013-10-07 | 2016-07-06 | 赛卢拉研究公司 | 用于以数字方式对阵列上的特征进行计数的方法和系统 |
| CA2929108A1 (en) | 2013-10-29 | 2015-05-07 | Longhorn Vaccines And Diagnostics, Llc | Next generation genomic sequencing methods |
| EP3073967A1 (en) | 2013-11-26 | 2016-10-05 | Xenco Medical, LLC | Lock and release implant delivery system |
| CN110219055A (zh) | 2013-11-27 | 2019-09-10 | Gen9股份有限公司 | 核酸文库及其制造方法 |
| US20160297883A1 (en) | 2013-12-04 | 2016-10-13 | Innovative Targeting Solutions, Inc. | G-protein coupled receptor agonists and methods |
| TWI702316B (zh) | 2013-12-04 | 2020-08-21 | 日商中外製藥股份有限公司 | 因應化合物濃度使抗原結合能力變化的抗原結合分子及其資料庫 |
| EP3102676A1 (en) | 2013-12-09 | 2016-12-14 | Integrated DNA Technologies Inc. | Long nucleic acid sequences containing variable regions |
| ES2763429T5 (es) | 2013-12-17 | 2023-06-21 | Hoffmann La Roche | Procedimientos de tratamiento de cánceres usando antagonistas de la unión al eje de PD-1 y taxanos |
| GB2521387B (en) | 2013-12-18 | 2020-05-27 | Ge Healthcare Uk Ltd | Oligonucleotide data storage on solid supports |
| US10537889B2 (en) | 2013-12-31 | 2020-01-21 | Illumina, Inc. | Addressable flow cell using patterned electrodes |
| US9587268B2 (en) | 2014-01-29 | 2017-03-07 | Agilent Technologies Inc. | Fast hybridization for next generation sequencing target enrichment |
| US10287627B2 (en) | 2014-02-08 | 2019-05-14 | The Regents Of The University Of Colorado, A Body Corporate | Multiplexed linking PCR |
| US10208338B2 (en) | 2014-03-03 | 2019-02-19 | Swift Biosciences, Inc. | Enhanced adaptor ligation |
| ES2740930T3 (es) | 2014-03-14 | 2020-02-07 | Immunocore Ltd | Bibliotecas de TCR |
| US10675618B2 (en) | 2014-03-27 | 2020-06-09 | University Of Maryland, College Park | Integration of ex situ fabricated porous polymer monoliths into fluidic chips |
| US10190161B2 (en) | 2014-04-03 | 2019-01-29 | Stmicroelectronics S.R.L. | Apparatus and method for nucleic acid sequencing based on nanowire detectors |
| US20170037790A1 (en) | 2014-04-15 | 2017-02-09 | Volvo Construction Equipment Ab | Device for controlling engine and hydraulic pump of construction equipment and control method therefor |
| GB201407852D0 (en) | 2014-05-02 | 2014-06-18 | Iontas Ltd | Preparation of libraries od protein variants expressed in eukaryotic cells and use for selecting binding molecules |
| AU2015259024B2 (en) | 2014-05-16 | 2021-07-01 | Illumina, Inc. | Nucleic acid synthesis techniques |
| US20150361423A1 (en) | 2014-06-16 | 2015-12-17 | Agilent Technologies, Inc. | High throughput gene assembly in droplets |
| US20150361422A1 (en) | 2014-06-16 | 2015-12-17 | Agilent Technologies, Inc. | High throughput gene assembly in droplets |
| US10472620B2 (en) | 2014-07-01 | 2019-11-12 | General Electric Company | Method, substrate and device for separating nucleic acids |
| US10870845B2 (en) | 2014-07-01 | 2020-12-22 | Global Life Sciences Solutions Operations UK Ltd | Methods for capturing nucleic acids |
| WO2016007604A1 (en) | 2014-07-09 | 2016-01-14 | Gen9, Inc. | Compositions and methods for site-directed dna nicking and cleaving |
| EP3169776B1 (en) | 2014-07-14 | 2025-09-03 | The Regents of The University of California | Crispr/cas transcriptional modulation |
| US20160017394A1 (en) | 2014-07-15 | 2016-01-21 | Life Technologies Corporation | Compositions and methods for nucleic acid assembly |
| WO2016022557A1 (en) | 2014-08-05 | 2016-02-11 | Twist Bioscience Corporation | Cell free cloning of nucleic acids |
| US10450562B2 (en) | 2014-09-09 | 2019-10-22 | Igenomx International Genomics Corporation | Methods and compositions for rapid nucleic acid library preparation |
| WO2016053881A1 (en) | 2014-10-03 | 2016-04-07 | Life Technologies Corporation | Genetic sequence verification compositions, methods and kits |
| CN113930455A (zh) | 2014-10-09 | 2022-01-14 | 生命技术公司 | Crispr寡核苷酸和基因剪辑 |
| EP3204518B1 (en) | 2014-10-10 | 2019-07-10 | Invitae Corporation | Universal blocking oligo system and improved hybridization capture methods for multiplexed capture reactions |
| US20170249345A1 (en) | 2014-10-18 | 2017-08-31 | Girik Malik | A biomolecule based data storage system |
| US10434507B2 (en) | 2014-10-22 | 2019-10-08 | The Regents Of The University Of California | High definition microdroplet printer |
| US9890417B2 (en) | 2014-11-03 | 2018-02-13 | Agilent Technologies, Inc. | Signal amplification of fluorescence in situ hybridization |
| US10233490B2 (en) | 2014-11-21 | 2019-03-19 | Metabiotech Corporation | Methods for assembling and reading nucleic acid sequences from mixed populations |
| CN104562213A (zh) | 2014-12-26 | 2015-04-29 | 北京诺禾致源生物信息科技有限公司 | 扩增子文库及其构建方法 |
| CA2975852A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Methods and devices for de novo oligonucleic acid assembly |
| CA2975855C (en) | 2015-02-04 | 2025-09-23 | Twist Bioscience Corporation | SYNTHETIC GENE COMPOSITIONS AND ASSEMBLY METHODS |
| US9834774B2 (en) | 2015-02-11 | 2017-12-05 | Agilent Technologies, Inc. | Methods and compositions for rapid seamless DNA assembly |
| WO2016130868A2 (en) | 2015-02-13 | 2016-08-18 | Vaccine Research Institute Of San Diego | Materials and methods to analyze rna isoforms in transcriptomes |
| CN104734848A (zh) * | 2015-03-02 | 2015-06-24 | 郑州轻工业学院 | 基于重组dna技术对信息进行加密与隐藏的方法及应用 |
| US10745456B2 (en) | 2015-04-01 | 2020-08-18 | The Scripps Research Institute | Methods and compositions related to GPCR agonist polypeptides |
| WO2016162127A1 (en) | 2015-04-08 | 2016-10-13 | Polyphor Ag | Backbone-cyclized peptidomimetics |
| WO2016164779A1 (en) * | 2015-04-10 | 2016-10-13 | University Of Washington | Integrated system for nucleic acid-based storage of digital data |
| US10125198B2 (en) | 2015-04-17 | 2018-11-13 | Distributed Bio, Inc. | Method for mass humanization of non-human antibodies |
| WO2016172377A1 (en) | 2015-04-21 | 2016-10-27 | Twist Bioscience Corporation | Devices and methods for oligonucleic acid library synthesis |
| US11685773B2 (en) | 2015-04-30 | 2023-06-27 | Abcheck S.R.O. | Method for mass humanization of rabbit antibodies |
| US20160333340A1 (en) | 2015-05-11 | 2016-11-17 | Twist Bioscience Corporation | Compositions and methods for nucleic acid amplification |
| JP6920275B2 (ja) | 2015-07-13 | 2021-08-18 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 核酸を用いた回収可能な情報記憶のための方法 |
| CN105119717A (zh) * | 2015-07-21 | 2015-12-02 | 郑州轻工业学院 | 一种基于dna编码的加密系统及加密方法 |
| KR20180050411A (ko) | 2015-09-18 | 2018-05-14 | 트위스트 바이오사이언스 코포레이션 | 올리고핵산 변이체 라이브러리 및 그의 합성 |
| WO2017053450A1 (en) | 2015-09-22 | 2017-03-30 | Twist Bioscience Corporation | Flexible substrates for nucleic acid synthesis |
| US20180320166A1 (en) | 2015-10-01 | 2018-11-08 | University Of Washington | Multiplex pairwise assembly of dna oligonucleotides |
| US20170141793A1 (en) | 2015-11-13 | 2017-05-18 | Microsoft Technology Licensing, Llc | Error correction for nucleotide data stores |
| EP3384077A4 (en) | 2015-12-01 | 2019-05-08 | Twist Bioscience Corporation | FUNCTIONALIZED SURFACES AND MANUFACTURE THEREOF |
| WO2017100441A1 (en) | 2015-12-08 | 2017-06-15 | Twinstrand Biosciences, Inc. | Improved adapters, methods, and compositions for duplex sequencing |
| WO2017118761A1 (en) | 2016-01-08 | 2017-07-13 | Iontas Ltd | Binding members with altered diversity scaffold domains |
| GB201604492D0 (en) | 2016-03-16 | 2016-04-27 | Immatics Biotechnologies Gmbh | Transfected t-cells and t-cell receptors for use in immunotherapy against cancers |
| CN105838711A (zh) * | 2016-05-09 | 2016-08-10 | 张阳 | 一种用于信息存储和加密的单链脱氧核糖核酸 |
| WO2017214574A1 (en) | 2016-06-10 | 2017-12-14 | Twist Bioscience Corporation | Systems and methods for automated annotation and screening of biological sequences |
| WO2017214557A1 (en) | 2016-06-10 | 2017-12-14 | Counsyl, Inc. | Nucleic acid sequencing adapters and uses thereof |
| CN110088281A (zh) | 2016-08-03 | 2019-08-02 | 特韦斯特生物科学公司 | 用于多核苷酸合成的纹理化表面 |
| WO2018038772A1 (en) | 2016-08-22 | 2018-03-01 | Twist Bioscience Corporation | De novo synthesized nucleic acid libraries |
| CN117298260A (zh) | 2016-09-02 | 2023-12-29 | 莱蒂恩技术公司 | 用DuoCAR治疗癌症的组合物和方法 |
| EP4664304A3 (en) | 2016-09-21 | 2026-01-21 | Atlas Data Storage, Inc. | Nucleic acid based data storage |
| AU2017363204B2 (en) | 2016-11-18 | 2022-12-08 | Twist Bioscience Corporation | Polynucleotide libraries having controlled stoichiometry and synthesis thereof |
| GB2573069A (en) | 2016-12-16 | 2019-10-23 | Twist Bioscience Corp | Variant libraries of the immunological synapse and synthesis thereof |
| HRP20250482T1 (hr) | 2016-12-21 | 2025-06-20 | Cephalon Llc | Protutijela koja se specifično vežu na ljudski il-15 i njihove uporabe |
| WO2018156792A1 (en) | 2017-02-22 | 2018-08-30 | Twist Bioscience Corporation | Nucleic acid based data storage |
| CA3056388A1 (en) | 2017-03-15 | 2018-09-20 | Twist Bioscience Corporation | Variant libraries of the immunological synapse and synthesis thereof |
| AU2018234624B2 (en) | 2017-03-15 | 2023-11-16 | Twist Bioscience Corporation | De novo synthesized combinatorial nucleic acid libraries |
| SG11201907891XA (en) | 2017-03-23 | 2019-09-27 | QBiotics Pty Ltd | Combination therapy for the treatment or prevention of tumours |
| WO2018183918A1 (en) | 2017-03-30 | 2018-10-04 | Grail, Inc. | Enhanced ligation in sequencing library preparation |
| CN111094584B (zh) | 2017-04-23 | 2024-11-26 | 伊鲁米那股份有限公司 | 用于改进编索引的核酸文库中的样品鉴定的组合物和方法 |
| SG11201910070PA (en) | 2017-05-08 | 2019-11-28 | Illumina Inc | Universal short adapters for indexing of polynucleotide samples |
| WO2018231864A1 (en) | 2017-06-12 | 2018-12-20 | Twist Bioscience Corporation | Methods for seamless nucleic acid assembly |
| IL271205B2 (en) | 2017-06-12 | 2025-02-01 | Twist Bioscience Corp | Methods for assembling continuous nucleic acids |
| US11666863B2 (en) | 2017-07-18 | 2023-06-06 | Investigaciones Forestales Bioforest S.A. | Method and device for asymmetric polarity inversion in electromembrane processes |
| CN111566125A (zh) | 2017-09-11 | 2020-08-21 | 特韦斯特生物科学公司 | Gpcr结合蛋白及其合成 |
| CN111565834B (zh) | 2017-10-20 | 2022-08-26 | 特韦斯特生物科学公司 | 用于多核苷酸合成的加热的纳米孔 |
| US20200299684A1 (en) | 2017-10-27 | 2020-09-24 | Twist Bioscience Corporation | Systems and methods for polynucleotide scoring |
| US11427867B2 (en) | 2017-11-29 | 2022-08-30 | Xgenomes Corp. | Sequencing by emergence |
| IL312616B2 (en) | 2018-01-04 | 2025-08-01 | Twist Bioscience Corp | Dna-based digital information storage |
| US10722916B2 (en) | 2018-01-19 | 2020-07-28 | Caulk Garbage Can LLC | Caulk gun attachment for wiping excess caulk |
| EP3814497A4 (en) | 2018-05-18 | 2022-03-02 | Twist Bioscience Corporation | POLYNUCLEOTIDES, REAGENTS AND METHODS FOR NUCLEIC ACID HYBRIDIZATION |
| US20210147830A1 (en) | 2018-06-29 | 2021-05-20 | Thermo Fisher Scientific Geneart Gmbh | High throughput assembly of nucleic acid molecules |
| US10963953B2 (en) | 2018-10-10 | 2021-03-30 | Alliance Inspection Management, LLC | Reserve management for continuous bidding portal |
| EP3902816A4 (en) | 2018-12-26 | 2022-09-14 | Twist Bioscience Corporation | HIGH-PRECISION DE NOVO POLYNUCLEOTIDE SYNTHESIS |
| CN113728100A (zh) | 2019-02-25 | 2021-11-30 | 特韦斯特生物科学公司 | 用于下一代测序的组合物和方法 |
| CA3131689A1 (en) | 2019-02-26 | 2020-09-03 | Twist Bioscience Corporation | Variant nucleic acid libraries for glp1 receptor |
| KR20210144698A (ko) | 2019-02-26 | 2021-11-30 | 트위스트 바이오사이언스 코포레이션 | 항체 최적화를 위한 변이 핵산 라이브러리 |
| US20220243195A1 (en) | 2019-06-21 | 2022-08-04 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
| EP3987019A4 (en) | 2019-06-21 | 2023-04-19 | Twist Bioscience Corporation | Barcode-based nucleic acid sequence assembly |
| US20220259638A1 (en) | 2019-07-22 | 2022-08-18 | Igenomx International Genomics Corporation | Methods and compositions for high throughput sample preparation using double unique dual indexing |
| EP4028586A4 (en) | 2019-09-13 | 2023-10-04 | University Health Network | DETECTION OF CIRCULATIVE TUMOR DNA USING DOUBLE-STRANDED HYBRID CAPTURE |
| CN115023440B (zh) | 2019-09-23 | 2025-09-12 | 特韦斯特生物科学公司 | 结合CD3ε的抗体 |
| US12091777B2 (en) | 2019-09-23 | 2024-09-17 | Twist Bioscience Corporation | Variant nucleic acid libraries for CRTH2 |
| AU2020400030B2 (en) | 2019-12-09 | 2026-05-21 | Twist Bioscience Corporation | Variant nucleic acid libraries for adenosine receptors |
| BR112022021780A2 (pt) | 2020-04-27 | 2023-03-07 | Twist Bioscience Corp | Bibliotecas de ácido nucléico variantes para coronavírus |
| EP4179001A4 (en) | 2020-07-07 | 2024-07-10 | Twist Bioscience Corporation | DEVICES AND METHODS FOR LIGHT ORIENTATION POLYMER SYNTHESIS |
| US20220106586A1 (en) | 2020-08-25 | 2022-04-07 | Twist Bioscience Corporation | Compositions and methods for library sequencing |
| CA3190667A1 (en) | 2020-08-26 | 2022-03-03 | Aaron Sato | Methods and compositions relating to glp1r variants |
| US12534494B2 (en) | 2020-08-28 | 2026-01-27 | Twist Bioscience Corporation | Devices and methods for synthesis |
| WO2022076326A1 (en) | 2020-10-05 | 2022-04-14 | Twist Bioscience Corporation | Hybridization methods and reagents |
| EP4229210A4 (en) | 2020-10-19 | 2025-01-08 | Twist Bioscience Corporation | METHOD FOR THE SYNTHESIS OF OLIGONUCLEOTIDES USING BOUND NUCLEOTIDES |
| WO2022087293A1 (en) | 2020-10-22 | 2022-04-28 | Twist Bioscience Corporation | Methods and systems for detecting coronavirus |
| WO2022093811A1 (en) | 2020-10-26 | 2022-05-05 | Twist Bioscience Corporation | Libraries for next generation sequencing |
| US20220135690A1 (en) | 2020-11-03 | 2022-05-05 | Twist Bioscience Corporation | Methods and compositions relating to chemokine receptor variants |
| WO2022159620A1 (en) | 2021-01-21 | 2022-07-28 | Twist Bioscience Corporation | Methods and compositions relating to adenosine receptors |
| WO2022178137A1 (en) | 2021-02-19 | 2022-08-25 | Twist Bioscience Corporation | Libraries for identification of genomic variants |
| WO2022204309A1 (en) | 2021-03-24 | 2022-09-29 | Twist Bioscience Corporation | Variant nucleic acid libraries for tigit |
-
2018
- 2018-02-22 WO PCT/US2018/019268 patent/WO2018156792A1/en not_active Ceased
- 2018-02-22 CN CN202410244507.5A patent/CN118116478A/zh active Pending
- 2018-02-22 CA CA3287278A patent/CA3287278A1/en active Pending
- 2018-02-22 EP EP25151767.8A patent/EP4556433A3/en active Pending
- 2018-02-22 KR KR1020247035574A patent/KR20240158370A/ko active Pending
- 2018-02-22 KR KR1020197027305A patent/KR102723464B1/ko active Active
- 2018-02-22 US US15/902,855 patent/US11550939B2/en active Active
- 2018-02-22 JP JP2019545334A patent/JP2020508661A/ja active Pending
- 2018-02-22 CN CN201880026589.9A patent/CN110892485B/zh active Active
- 2018-02-22 EP EP18756866.2A patent/EP3586255B1/en active Active
- 2018-02-22 SG SG11201907713WA patent/SG11201907713WA/en unknown
-
2022
- 2022-12-05 US US18/061,956 patent/US20230153452A1/en active Pending
-
2026
- 2026-03-02 JP JP2026032872A patent/JP2026116894A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20240158370A (ko) | 2024-11-04 |
| US20180253563A1 (en) | 2018-09-06 |
| JP2020508661A (ja) | 2020-03-26 |
| EP3586255B1 (en) | 2025-01-15 |
| WO2018156792A1 (en) | 2018-08-30 |
| CN110892485A (zh) | 2020-03-17 |
| EP4556433A3 (en) | 2025-08-06 |
| CN118116478A (zh) | 2024-05-31 |
| SG11201907713WA (en) | 2019-09-27 |
| EP4556433A2 (en) | 2025-05-21 |
| US11550939B2 (en) | 2023-01-10 |
| CN110892485B (zh) | 2024-03-22 |
| CA3054303A1 (en) | 2018-08-30 |
| JP2026116894A (ja) | 2026-07-14 |
| US20230153452A1 (en) | 2023-05-18 |
| KR102723464B1 (ko) | 2024-10-28 |
| KR20190119107A (ko) | 2019-10-21 |
| EP3586255A4 (en) | 2021-03-31 |
| EP3586255A1 (en) | 2020-01-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12056264B2 (en) | Nucleic acid based data storage | |
| KR102723464B1 (ko) | 핵산 기반 데이터 저장 | |
| US20250154589A1 (en) | Flexible substrates for nucleic acid synthesis | |
| US12086722B2 (en) | DNA-based digital information storage with sidewall electrodes | |
| US20240378459A1 (en) | Dna-based digital information storage with sidewall electrodes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A16 | Divisional, continuation or continuation in part application filed |
Free format text: ST27 STATUS EVENT CODE: A-0-1-A10-A16-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: APPLICATION RECEIVED - DIVISIONAL Effective date: 20250925 |
|
| MFA | Maintenance fee for application paid |
Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 6TH ANNIV.) - STANDARD Year of fee payment: 6 Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 7TH ANNIV.) - STANDARD Year of fee payment: 7 Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 5TH ANNIV.) - STANDARD Year of fee payment: 5 Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 4TH ANNIV.) - STANDARD Year of fee payment: 4 Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 2ND ANNIV.) - STANDARD Year of fee payment: 2 Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 3RD ANNIV.) - STANDARD Year of fee payment: 3 |
|
| R11 | Change to the name of applicant or owner or transfer of ownership requested |
Free format text: ST27 STATUS EVENT CODE: A-1-1-R10-R11-R127 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TRANSFER RECORDAL REQUEST OR RESPONSE Effective date: 20251002 Free format text: ST27 STATUS EVENT CODE: A-1-1-R10-R11-R103 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CHANGE OF NAME REQUEST RECEIVED Effective date: 20251002 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT Effective date: 20251006 |
|
| A18 | Application divided or continuation or continuation in part accepted |
Free format text: ST27 STATUS EVENT CODE: A-1-1-A10-A18-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: DIVISIONAL REQUIREMENTS DETERMINED COMPLIANT Effective date: 20251120 |
|
| P18 | Priority claim added or amended |
Free format text: ST27 STATUS EVENT CODE: A-1-1-P10-P18-P112 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: PRIORITY DOCUMENT OR RESPONSE DETERMINED COMPLIANT Effective date: 20251120 Free format text: ST27 STATUS EVENT CODE: A-1-1-P10-P18-P105 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: PRIORITY CLAIM REQUIREMENTS DETERMINED COMPLIANT Effective date: 20251120 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20251120 |
|
| R14 | Transfer of ownership recorded |
Free format text: ST27 STATUS EVENT CODE: A-1-1-R10-R14-R129 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TRANSFER REQUIREMENTS DETERMINED COMPLIANT Effective date: 20251211 |
|
| D11 | Substantive examination requested |
Free format text: ST27 STATUS EVENT CODE: A-1-1-D10-D11-D117 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: REQUEST FOR EXAMINATION RECEIVED Effective date: 20251222 |
|
| P11 | Amendment of application requested |
Free format text: ST27 STATUS EVENT CODE: A-1-1-P10-P11-P101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT RECEIVED - VOLUNTARY AMENDMENT Effective date: 20251222 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT Effective date: 20251222 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT Effective date: 20260209 |
|
| R13 | Change to the name of applicant or owner recorded |
Free format text: ST27 STATUS EVENT CODE: A-1-1-R10-R13-R104 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CHANGE OF NAME REQUIREMENTS DETERMINED COMPLIANT Effective date: 20260220 |
|
| Q12 | Application published |
Free format text: ST27 STATUS EVENT CODE: A-1-1-Q10-Q12-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: APPLICATION PUBLISHED (OPEN TO PUBLIC INSPECTION) Effective date: 20260302 |
|
| P11 | Amendment of application requested |
Free format text: ST27 STATUS EVENT CODE: A-1-1-P10-P11-P102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT DETERMINED COMPLIANT Effective date: 20260312 |
|
| P13 | Application amended |
Free format text: ST27 STATUS EVENT CODE: A-1-1-P10-P13-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: APPLICATION AMENDED Effective date: 20260312 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20260407 |
|
| MFA | Maintenance fee for application paid |
Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 8TH ANNIV.) - STANDARD Year of fee payment: 8 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20260414 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-1-1-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20260414 |
|
| P22 | Classification modified |
Free format text: ST27 STATUS EVENT CODE: A-1-1-P10-P22-P110 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CLASSIFICATION MODIFIED Effective date: 20260417 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20260514 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20260728 |