SG11201907713WA - Nucleic acid based data storage - Google Patents

Nucleic acid based data storage

Info

Publication number
SG11201907713WA
SG11201907713WA SG11201907713WA SG11201907713WA SG11201907713WA SG 11201907713W A SG11201907713W A SG 11201907713WA SG 11201907713W A SG11201907713W A SG 11201907713WA SG 11201907713W A SG11201907713W A SG 11201907713WA SG 11201907713W A SG11201907713W A SG 11201907713WA
Authority
SG
Singapore
Prior art keywords
international
rule
california
pct
applicant
Prior art date
Application number
SG11201907713WA
Inventor
Bill James Peck
Ramsey Ibrahim ZEITOUN
Original Assignee
Twist Bioscience Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Twist Bioscience Corp filed Critical Twist Bioscience Corp
Publication of SG11201907713WA publication Critical patent/SG11201907713WA/en

Links

Classifications

    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F21/00—Security arrangements for protecting computers, components thereof, programs or data against unauthorised activity
    • G06F21/60—Protecting data
    • G06F21/62—Protecting access to data via a platform, e.g. using keys or access control rules
    • G06F21/6218—Protecting access to data via a platform, e.g. using keys or access control rules to a system of files or objects, e.g. local or distributed file system or database
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11C—STATIC STORES
    • G11C11/00—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor
    • G11C11/54—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using elements simulating biological cells, e.g. neuron
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11C—STATIC STORES
    • G11C13/00—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00
    • G11C13/0002—Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00 using resistive RAM [RRAM] elements
    • G11C13/0009—RRAM elements whose operation depends upon chemical change
    • G11C13/0014—RRAM elements whose operation depends upon chemical change comprising cells based on organic memory material
    • G11C13/0019—RRAM elements whose operation depends upon chemical change comprising cells based on organic memory material comprising bio-molecules
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
    • G16B50/30—Data warehousing; Computing architectures
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
    • G16B50/40—Encryption of genetic data
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
    • H04L9/00—Cryptographic mechanisms or cryptographic arrangements for secret or secure communications; Network security protocols
    • H04L9/32—Cryptographic mechanisms or cryptographic arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system or for message authentication, e.g. authorization, entity authentication, data integrity or data verification, non-repudiation, key authentication or verification of credentials
    • H04L9/3226—Cryptographic mechanisms or cryptographic arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system or for message authentication, e.g. authorization, entity authentication, data integrity or data verification, non-repudiation, key authentication or verification of credentials using a predetermined code, e.g. password, passphrase or PIN
    • H04L9/3231—Biological data, e.g. fingerprint, voice or retina
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 30 August 2018 (30.08.2018) WIP0 I PCT °Ens °nolo moll loomilioloin oimIE (10) International Publication Number WO 2018/156792 Al (51) International Patent Classification: GOOF 19/22 (2011.01) G11C 13/00 (2006.01) B82Y 10/00 (2011.01) (21) International Application Number: PCT/US2018/019268 (22) International Filing Date: 22 February 2018 (22.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/462,284 22 February 2017 (22.02.2017) US (71) Applicant: TWIST BIOSCIENCE CORPORATION [US/US]; 455 Mission Bay Boulevard South, Suite 545, San Francisco, California 94158 (US). (72) Inventors: PECK, Bill James; 3086 Carleton Place, San- ta Clara, California 95051 (US). ZEITOUN, Ramsey Ibrahim; 1010 16th Street, Apt. 608, San Francisco, Cali- fornia 94107 (US). (74) Agent: HARBURGER, David; WILSON SONSINI GOODRICH & ROSATI, 650 Page Mill Road, Palo Alto, California 94304 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: NUCLEIC ACID BASED DATA STORAGE 11111111111111111111111111111111111111111111111111111111111111111111111 403 402 404 1111111111111111111111111111111111111111111111111111111111111111111111 402 406 407 401 CI 405 409 1111111111> T 111111111111111111111111111111111111111111111111111141T A E1:3-1= / 11111111111) 11111111111111111111111111111111111111111111111111111111111 a 1M - 1=1 411 FIG. 4A (57) : Provided herein are compositions, devices, systems and methods for the generation and use of secured biomolecule-based information for storage. Further described herein are compositions, devices, systems and methods for bioencryption or biodecryption of information. Conversion of a digital sequence to a nucleic based sequence includes a step of selection of one or more bioencryption methods. [Continued on next page] WO 2018/156792 Al OII TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a))
SG11201907713WA 2017-02-22 2018-02-22 Nucleic acid based data storage SG11201907713WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762462284P 2017-02-22 2017-02-22
PCT/US2018/019268 WO2018156792A1 (en) 2017-02-22 2018-02-22 Nucleic acid based data storage

Publications (1)

Publication Number Publication Date
SG11201907713WA true SG11201907713WA (en) 2019-09-27

Family

ID=63254091

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201907713WA SG11201907713WA (en) 2017-02-22 2018-02-22 Nucleic acid based data storage

Country Status (8)

Country Link
US (2) US11550939B2 (en)
EP (1) EP3586255A4 (en)
JP (1) JP2020508661A (en)
KR (1) KR20190119107A (en)
CN (1) CN110892485B (en)
CA (1) CA3054303A1 (en)
SG (1) SG11201907713WA (en)
WO (1) WO2018156792A1 (en)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI695067B (en) 2013-08-05 2020-06-01 美商扭轉生物科技有限公司 De novo synthesized gene libraries
US10669304B2 (en) 2015-02-04 2020-06-02 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
US9981239B2 (en) 2015-04-21 2018-05-29 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
KR20180050411A (en) 2015-09-18 2018-05-14 트위스트 바이오사이언스 코포레이션 Oligonucleotide mutant library and its synthesis
CN108698012A (en) 2015-09-22 2018-10-23 特韦斯特生物科学公司 Flexible substrates for nucleic acid synthesis
EP3384077A4 (en) 2015-12-01 2019-05-08 Twist Bioscience Corporation Functionalized surfaces and preparation thereof
AU2017315294B2 (en) 2016-08-22 2023-12-21 Twist Bioscience Corporation De novo synthesized nucleic acid libraries
EP3509018B1 (en) * 2016-08-30 2023-10-18 Tsinghua University Method for biologically storing and restoring data
US10417457B2 (en) 2016-09-21 2019-09-17 Twist Bioscience Corporation Nucleic acid based data storage
US10650312B2 (en) 2016-11-16 2020-05-12 Catalog Technologies, Inc. Nucleic acid-based data storage
KR102534408B1 (en) 2016-11-16 2023-05-18 카탈로그 테크놀로지스, 인크. Nucleic acid-based data storage
CN110366613A (en) 2016-12-16 2019-10-22 特韦斯特生物科学公司 The Mutant libraries of immunological synapse and its synthesis
US11550939B2 (en) 2017-02-22 2023-01-10 Twist Bioscience Corporation Nucleic acid based data storage using enzymatic bioencryption
CN110913865A (en) 2017-03-15 2020-03-24 特韦斯特生物科学公司 Library of variants of immune synapses and synthesis thereof
WO2018231864A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
KR102628876B1 (en) 2017-06-12 2024-01-23 트위스트 바이오사이언스 코포레이션 Methods for seamless nucleic acid assembly
CN111566125A (en) 2017-09-11 2020-08-21 特韦斯特生物科学公司 GPCR binding proteins and synthesis thereof
CA3079613A1 (en) 2017-10-20 2019-04-25 Twist Bioscience Corporation Heated nanowells for polynucleotide synthesis
SG11201903333SA (en) 2017-12-29 2019-08-27 Clear Labs Inc Automated priming and library loading services
CA3088911A1 (en) 2018-01-04 2019-07-11 Twist Bioscience Corporation Dna-based digital information storage
JP7364604B2 (en) 2018-03-16 2023-10-18 カタログ テクノロジーズ， インコーポレイテッド Chemical methods for nucleic acid-based data storage
US11302421B2 (en) * 2018-04-13 2022-04-12 The Hong Kong Polytechnic University Data storage using peptides
EP3776557A4 (en) * 2018-04-13 2021-12-15 The Hong Kong Polytechnic University Data storage using peptides
US20200193301A1 (en) 2018-05-16 2020-06-18 Catalog Technologies, Inc. Compositions and methods for nucleic acid-based data storage
AU2019270243A1 (en) 2018-05-18 2021-01-07 Twist Bioscience Corporation Polynucleotides, reagents, and methods for nucleic acid hybridization
US11456759B2 (en) * 2018-05-25 2022-09-27 Erlich Lab Llc Optimized encoding for storage of data on polymers in asynchronous synthesis
US10227576B1 (en) * 2018-06-13 2019-03-12 Caribou Biosciences, Inc. Engineered cascade components and cascade complexes
US11781169B2 (en) * 2018-10-05 2023-10-10 Microsoft Technology Licensing, Llc Enzymatic DNA repair
US20220064705A1 (en) * 2018-12-26 2022-03-03 Bgi Shenzhen Method and device for fixed-point editing of nucleotide sequence with stored data
KR20210143766A (en) 2019-02-26 2021-11-29 트위스트 바이오사이언스 코포레이션 Variant Nucleic Acid Libraries for the GLP1 Receptor
KR20210144698A (en) 2019-02-26 2021-11-30 트위스트 바이오사이언스 코포레이션 Variant Nucleic Acid Libraries for Antibody Optimization
KR20220017409A (en) 2019-05-09 2022-02-11 카탈로그 테크놀로지스, 인크. Data structures and behaviors for searching, computing, and indexing in DNA-based data stores.
GB201907460D0 (en) 2019-05-27 2019-07-10 Vib Vzw A method of storing information in pools of nucleic acid molecules
US10956806B2 (en) * 2019-06-10 2021-03-23 International Business Machines Corporation Efficient assembly of oligonucleotides for nucleic acid based data storage
US11332738B2 (en) 2019-06-21 2022-05-17 Twist Bioscience Corporation Barcode-based nucleic acid sequence assembly
WO2021072398A1 (en) 2019-10-11 2021-04-15 Catalog Technologies, Inc. Nucleic acid security and authentication
EP4150622A1 (en) 2020-05-11 2023-03-22 Catalog Technologies, Inc. Programs and functions in dna-based data storage
CN111724841B (en) * 2020-06-04 2022-06-10 中国科学院上海微系统与信息技术研究所 Information storage method based on biological protein
CN112711740A (en) * 2020-12-29 2021-04-27 湖北伯远合成生物科技有限公司 DNA anti-counterfeit label system

Family Cites Families (919)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3549368A (en) 1968-07-02 1970-12-22 Ibm Process for improving photoresist adhesion
US3920714A (en) 1972-11-16 1975-11-18 Weber Heinrich Process for the production of polymeric hydrocarbons with reactive silyl side groups
GB1550867A (en) 1975-08-04 1979-08-22 Hughes Aircraft Co Positioning method and apparatus for fabricating microcircuit devices
US4415732A (en) 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
EP0090789A1 (en) 1982-03-26 1983-10-05 Monsanto Company Chemical DNA synthesis
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
JPS59224123A (en) 1983-05-20 1984-12-17 Oki Electric Ind Co Ltd Alignment mark for wafer
US5118605A (en) 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
JPS61141761A (en) 1984-12-12 1986-06-28 Kanegafuchi Chem Ind Co Ltd Curable composition
US5242794A (en) 1984-12-13 1993-09-07 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
US6492107B1 (en) 1986-11-20 2002-12-10 Stuart Kauffman Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
US4613398A (en) 1985-06-06 1986-09-23 International Business Machines Corporation Formation of etch-resistant resists through preferential permeation
US4981797A (en) 1985-08-08 1991-01-01 Life Technologies, Inc. Process of producing highly transformable cells and cells produced thereby
US4726877A (en) 1986-01-22 1988-02-23 E. I. Du Pont De Nemours And Company Methods of using photosensitive compositions containing microgels
US4808511A (en) 1987-05-19 1989-02-28 International Business Machines Corporation Vapor phase photoresist silylation process
JPH07113774B2 (en) 1987-05-29 1995-12-06 株式会社日立製作所 Pattern formation method
US4988617A (en) 1988-03-25 1991-01-29 California Institute Of Technology Method of detecting a nucleotide change in nucleic acids
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
EP0385410B1 (en) 1989-02-28 1996-10-02 Canon Kabushiki Kaisha Partially double-stranded oligonucleotide and method for forming oligonucleotide
US5459039A (en) 1989-05-12 1995-10-17 Duke University Methods for mapping genetic mutations
US6008031A (en) 1989-05-12 1999-12-28 Duke University Method of analysis and manipulation of DNA utilizing mismatch repair systems
US5556750A (en) 1989-05-12 1996-09-17 Duke University Methods and kits for fractionating a population of DNA molecules based on the presence or absence of a base-pair mismatch utilizing mismatch repair systems
US5102797A (en) 1989-05-26 1992-04-07 Dna Plant Technology Corporation Introduction of heterologous genes into bacteria using transposon flanked expression cassette and a binary vector system
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6309822B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US6919211B1 (en) 1989-06-07 2005-07-19 Affymetrix, Inc. Polypeptide arrays
US5527681A (en) 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5242974A (en) 1991-11-22 1993-09-07 Affymax Technologies N.V. Polymer reversal on solid surfaces
CA2036946C (en) 1990-04-06 2001-10-16 Kenneth V. Deugau Indexing linkers
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
US6087482A (en) 1990-07-27 2000-07-11 Isis Pharmaceuticals, Inc. Heteroatomic oligonucleoside linkages
EP0550693B1 (en) 1990-09-27 1996-04-24 Invitrogen Corporation Direct cloning of pcr amplified nucleic acids
GB9025236D0 (en) 1990-11-20 1991-01-02 Secr Defence Silicon-on porous-silicon;method of production
EP0834576B1 (en) 1990-12-06 2002-01-16 Affymetrix, Inc. (a Delaware Corporation) Detection of nucleic acid sequences
ES2155822T3 (en) 1990-12-06 2001-06-01 Affymetrix Inc COMPOUNDS AND ITS USE IN A BINARY SYNTHESIS STRATEGY.
US6582908B2 (en) 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
US5455166A (en) 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
US5137814A (en) 1991-06-14 1992-08-11 Life Technologies, Inc. Use of exo-sample nucleotides in gene cloning
US5449754A (en) 1991-08-07 1995-09-12 H & N Instruments, Inc. Generation of combinatorial libraries
US5474796A (en) 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US6759226B1 (en) 2000-05-24 2004-07-06 Third Wave Technologies, Inc. Enzymes for the detection of specific nucleic acid sequences
US5994069A (en) 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
US5846717A (en) 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US7045289B2 (en) 1991-09-09 2006-05-16 Third Wave Technologies, Inc. Detection of RNA Sequences
US7150982B2 (en) 1991-09-09 2006-12-19 Third Wave Technologies, Inc. RNA detection assays
WO1993009668A1 (en) 1991-11-22 1993-05-27 Affymax Technology N.V. Combinatorial strategies for polymer synthesis
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
ATE173767T1 (en) 1992-04-03 1998-12-15 Perkin Elmer Corp SAMPLES COMPOSITION AND METHODS
JP2553322Y2 (en) 1992-05-11 1997-11-05 サンデン株式会社 Filter feed mechanism of beverage brewing device
JPH07509365A (en) 1992-07-31 1995-10-19 デイド・ベーリング・マルブルク・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング Method for introducing a specific sequence into the 3' end of polynucleotides
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
JP3176444B2 (en) 1992-10-01 2001-06-18 株式会社リコー Aqueous ink and recording method using the same
DE4241045C1 (en) 1992-12-05 1994-05-26 Bosch Gmbh Robert Process for anisotropic etching of silicon
US5368823A (en) 1993-02-11 1994-11-29 University Of Georgia Research Foundation, Inc. Automated synthesis of oligonucleotides
US5395753A (en) 1993-02-19 1995-03-07 Theratech, Inc. Method for diagnosing rheumatoid arthritis
DE69433010T2 (en) 1993-04-12 2004-06-09 Northwestern University, Evanston METHOD FOR PRESENTING OLIGONUCLEOTIDES
US7135312B2 (en) 1993-04-15 2006-11-14 University Of Rochester Circular DNA vectors for synthesis of RNA and DNA
US5455239A (en) 1993-08-05 1995-10-03 Merck & Co. Inc. 3-aryl of heteroaryl-7-heteroaralkylamido cephalosporin compounds, compositions and methods of use
US5482845A (en) 1993-09-24 1996-01-09 The Trustees Of Columbia University In The City Of New York Method for construction of normalized cDNA libraries
CN1039623C (en) 1993-10-22 1998-09-02 中国人民解放军军事医学科学院毒物药物研究所 Medicinal composite for preventing and curing kinetosis syndrome
US6893816B1 (en) 1993-10-28 2005-05-17 Houston Advanced Research Center Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions
EP0725682B1 (en) 1993-10-28 2002-03-20 Houston Advanced Research Center Microfabricated, flowthrough porous apparatus
US6027877A (en) 1993-11-04 2000-02-22 Gene Check, Inc. Use of immobilized mismatch binding protein for detection of mutations and polymorphisms, purification of amplified DNA samples and allele identification
US5834252A (en) 1995-04-18 1998-11-10 Glaxo Group Limited End-complementary polymerase reaction
US6015880A (en) 1994-03-16 2000-01-18 California Institute Of Technology Method and substrate for performing multiple sequential reactions on a matrix
BR9507229A (en) 1994-03-29 1997-09-16 Novo Nordisk As Amylase detergent additive detergent composition use of a detergent and an amylase construction of a recombinant cell expression vector dna and process to produce amylase
US5514789A (en) 1994-04-21 1996-05-07 Barrskogen, Inc. Recovery of oligonucleotides by gas phase cleavage
SE512382C2 (en) 1994-04-26 2000-03-06 Ericsson Telefon Ab L M Device and method for placing elongate elements against or adjacent to a surface
DE69519783T2 (en) 1994-04-29 2001-06-07 Perkin Elmer Corp METHOD AND DEVICE FOR REAL-TIME DETECTION OF PRODUCTS OF NUCLEIC ACID AMPLIFICATION
US6287850B1 (en) 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
WO1996000378A1 (en) 1994-06-23 1996-01-04 Affymax Technologies N.V. Photolabile compounds and methods for their use
US5641658A (en) 1994-08-03 1997-06-24 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid with two primers bound to a single solid support
US5530516A (en) 1994-10-04 1996-06-25 Tamarack Scientific Co., Inc. Large-area projection exposure system
US6013445A (en) * 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US6613560B1 (en) 1994-10-19 2003-09-02 Agilent Technologies, Inc. PCR microreactor for amplifying DNA using microquantities of sample fluid
US6635226B1 (en) 1994-10-19 2003-10-21 Agilent Technologies, Inc. Microanalytical device and use thereof for conducting chemical processes
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
WO1996015861A1 (en) 1994-11-22 1996-05-30 Complex Fluid Systems, Inc. Non-aminic photoresist adhesion promoters for microelectronic applications
US5688642A (en) 1994-12-01 1997-11-18 The United States Of America As Represented By The Secretary Of The Navy Selective attachment of nucleic acid molecules to patterned self-assembled surfaces
US6017434A (en) 1995-05-09 2000-01-25 Curagen Corporation Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
US5700642A (en) 1995-05-22 1997-12-23 Sri International Oligonucleotide sizing using immobilized cleavable primers
US5877280A (en) 1995-06-06 1999-03-02 The Mount Sinai School Of Medicine Of The City University Of New York Thermostable muts proteins
US6446682B1 (en) 1995-06-06 2002-09-10 James P. Viken Auto-loading fluid exchanger and method of use
US5707806A (en) 1995-06-07 1998-01-13 Genzyme Corporation Direct sequence identification of mutations by cleavage- and ligation-associated mutation-specific sequencing
US5712126A (en) 1995-08-01 1998-01-27 Yale University Analysis of gene expression by display of 3-end restriction fragments of CDNA
US5780613A (en) 1995-08-01 1998-07-14 Northwestern University Covalent lock for self-assembled oligonucleotide constructs
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US6352842B1 (en) 1995-12-07 2002-03-05 Diversa Corporation Exonucease-mediated gene assembly in directed evolution
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
CA2240346C (en) 1995-12-15 2007-04-24 Amersham Life Science, Inc. Methods for the detection and removal of mutant sequences that arise during enzymatic amplification using mismatch repair systems
US5962271A (en) 1996-01-03 1999-10-05 Cloutech Laboratories, Inc. Methods and compositions for generating full-length cDNA having arbitrary nucleotide sequence at the 3'-end
US5976846A (en) 1996-01-13 1999-11-02 Passmore; Steven E. Method for multifragment in vivo cloning and mutation mapping
US5985557A (en) 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
US7527928B2 (en) 1996-11-29 2009-05-05 Third Wave Technologies, Inc. Reactions on a solid surface
US6090606A (en) 1996-01-24 2000-07-18 Third Wave Technologies, Inc. Cleavage agents
US7432048B2 (en) 1996-11-29 2008-10-07 Third Wave Technologies, Inc. Reactions on a solid surface
US7122364B1 (en) 1998-03-24 2006-10-17 Third Wave Technologies, Inc. FEN endonucleases
US6706471B1 (en) 1996-01-24 2004-03-16 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US6274369B1 (en) 1996-02-02 2001-08-14 Invitrogen Corporation Method capable of increasing competency of bacterial cell transformation
US6013440A (en) 1996-03-11 2000-01-11 Affymetrix, Inc. Nucleic acid affinity columns
US6020481A (en) 1996-04-01 2000-02-01 The Perkin-Elmer Corporation Asymmetric benzoxanthene dyes
US6706875B1 (en) 1996-04-17 2004-03-16 Affyemtrix, Inc. Substrate preparation process
US5869245A (en) 1996-06-05 1999-02-09 Fox Chase Cancer Center Mismatch endonuclease and its use in identifying mutations in targeted polynucleotide strands
US5863801A (en) 1996-06-14 1999-01-26 Sarnoff Corporation Automated nucleic acid isolation
US6780982B2 (en) 1996-07-12 2004-08-24 Third Wave Technologies, Inc. Charge tags and the separation of nucleic acid molecules
US5853993A (en) 1996-10-21 1998-12-29 Hewlett-Packard Company Signal enhancement method and kit
WO1998022541A2 (en) 1996-11-08 1998-05-28 Ikonos Corporation Method for coating substrates
US5750672A (en) 1996-11-22 1998-05-12 Barrskogen, Inc. Anhydrous amine cleavage of oligonucleotides
AU737449B2 (en) 1996-11-29 2001-08-23 Third Wave Technologies, Inc. FEN-1 endonucleases, mixtures and cleavage methods
WO1998029736A1 (en) 1996-12-31 1998-07-09 Genometrix Incorporated Multiplexed molecular analysis apparatus and method
DE69829976T2 (en) 1997-02-12 2006-04-27 Invitrogen Corp., Carlsbad METHOD FOR PRODUCING CELLS
US5882496A (en) 1997-02-27 1999-03-16 The Regents Of The University Of California Porous silicon structures with high surface area/specific pore size
US6770748B2 (en) 1997-03-07 2004-08-03 Takeshi Imanishi Bicyclonucleoside and oligonucleotide analogue
US6419883B1 (en) 1998-01-16 2002-07-16 University Of Washington Chemical synthesis using solvent microdroplets
JP2001518086A (en) 1997-03-20 2001-10-09 ユニバーシティ オブ ワシントン Solvents, solvent microdroplets, and methods of use for biopolymer synthesis
US6028189A (en) 1997-03-20 2000-02-22 University Of Washington Solvent for oligonucleotide synthesis and methods of use
JP4245084B2 (en) 1997-03-21 2009-03-25 ストラタジーン Polymerase enhancing factor (PEF) extract, PEF protein complex, isolated PEF protein, and purification and isolation methods
US6969488B2 (en) 1998-05-22 2005-11-29 Solexa, Inc. System and apparatus for sequential processing of analytes
US5922593A (en) 1997-05-23 1999-07-13 Becton, Dickinson And Company Microbiological test panel and method therefor
DE69824586T2 (en) 1997-06-26 2005-06-23 PerSeptive Biosystems, Inc., Framingham SAMPLE HIGH DENSITY SAMPLE FOR THE ANALYSIS OF BIOLOGICAL SAMPLES
GB9714716D0 (en) 1997-07-11 1997-09-17 Brax Genomics Ltd Characterising nucleic acids
US5989872A (en) 1997-08-12 1999-11-23 Clontech Laboratories, Inc. Methods and compositions for transferring DNA sequence information among vectors
US6027898A (en) 1997-08-18 2000-02-22 Transgenomic, Inc. Chromatographic method for mutation detection using mutation site specifically acting enzymes and chemicals
US6794499B2 (en) 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
US6136568A (en) 1997-09-15 2000-10-24 Hiatt; Andrew C. De novo polynucleotide synthesis using rolling templates
US6670127B2 (en) 1997-09-16 2003-12-30 Egea Biosciences, Inc. Method for assembly of a polynucleotide encoding a target polypeptide
PT1538206E (en) 1997-09-16 2010-04-12 Centocor Ortho Biotech Inc Method for the complete chemical synthesis and assembly of genes and genomes
US5976842A (en) 1997-10-30 1999-11-02 Clontech Laboratories, Inc. Methods and compositions for use in high fidelity polymerase chain reaction
US8182991B1 (en) 1997-11-26 2012-05-22 Third Wave Technologies, Inc. FEN-1 endonucleases, mixtures and cleavage methods
US6408308B1 (en) 1998-01-29 2002-06-18 Incyte Pharmaceuticals, Inc. System and method for generating, analyzing and storing normalized expression datasets from raw expression datasets derived from microarray includes nucleic acid probe sequences
US6287776B1 (en) 1998-02-02 2001-09-11 Signature Bioscience, Inc. Method for detecting and classifying nucleic acid hybridization
US6251588B1 (en) 1998-02-10 2001-06-26 Agilent Technologies, Inc. Method for evaluating oligonucleotide probe sequences
EP1054726B1 (en) 1998-02-11 2003-07-30 University of Houston, Office of Technology Transfer Apparatus for chemical and biochemical reactions using photo-generated reagents
IL137901A (en) 1998-02-23 2004-07-25 Wisconsin Alumni Res Found Method and apparatus for synthesis of arrays of dna probes
JP4493844B2 (en) 1998-03-25 2010-06-30 ランデグレン、ウルフ Rolling circle replication of padlock probe
US6284497B1 (en) 1998-04-09 2001-09-04 Trustees Of Boston University Nucleic acid arrays and methods of synthesis
US7321828B2 (en) 1998-04-13 2008-01-22 Isis Pharmaceuticals, Inc. System of components for preparing oligonucleotides
CA2325013A1 (en) 1998-04-13 1999-10-21 Isis Pharmaceuticals Inc. Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation
US6376285B1 (en) 1998-05-28 2002-04-23 Texas Instruments Incorporated Annealed porous silicon with epitaxial layer for SOI
US6274725B1 (en) 1998-06-02 2001-08-14 Isis Pharmaceuticals, Inc. Activators for oligonucleotide synthesis
US6130045A (en) 1998-06-11 2000-10-10 Clontech Laboratories, Inc. Thermostable polymerase
US6251595B1 (en) 1998-06-18 2001-06-26 Agilent Technologies, Inc. Methods and devices for carrying out chemical reactions
EP0967217B1 (en) 1998-06-22 2005-12-21 Affymetrix, Inc. (a California Corporation) Reagents and methods for solid phase synthesis and display
US6218118B1 (en) 1998-07-09 2001-04-17 Agilent Technologies, Inc. Method and mixture reagents for analyzing the nucleotide sequence of nucleic acids by mass spectrometry
US7399844B2 (en) 1998-07-09 2008-07-15 Agilent Technologies, Inc. Method and reagents for analyzing the nucleotide sequence of nucleic acids
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
US20030022207A1 (en) 1998-10-16 2003-01-30 Solexa, Ltd. Arrayed polynucleotides and their use in genome analysis
US6222030B1 (en) 1998-08-03 2001-04-24 Agilent Technologies, Inc. Solid phase synthesis of oligonucleotides using carbonate protecting groups and alpha-effect nucleophile deprotection
US6991922B2 (en) 1998-08-12 2006-01-31 Proteus S.A. Process for in vitro creation of recombinant polynucleotide sequences by oriented ligation
US6951719B1 (en) 1999-08-11 2005-10-04 Proteus S.A. Process for obtaining recombined nucleotide sequences in vitro, libraries of sequences and sequences thus obtained
US6107038A (en) 1998-08-14 2000-08-22 Agilent Technologies Inc. Method of binding a plurality of chemicals on a substrate by electrophoretic self-assembly
EP1115424A1 (en) 1998-08-28 2001-07-18 Febit Ferrarius Biotechnology GmbH Method and measuring device for determining a plurality of analytes in a sample
US6258454B1 (en) 1998-09-01 2001-07-10 Agilent Technologies Inc. Functionalization of substrate surfaces with silane mixtures
US6461812B2 (en) 1998-09-09 2002-10-08 Agilent Technologies, Inc. Method and multiple reservoir apparatus for fabrication of biomolecular arrays
US6458583B1 (en) 1998-09-09 2002-10-01 Agilent Technologies, Inc. Method and apparatus for making nucleic acid arrays
US6287824B1 (en) 1998-09-15 2001-09-11 Yale University Molecular cloning using rolling circle amplification
AR021833A1 (en) 1998-09-30 2002-08-07 Applied Research Systems METHODS OF AMPLIFICATION AND SEQUENCING OF NUCLEIC ACID
US6399516B1 (en) 1998-10-30 2002-06-04 Massachusetts Institute Of Technology Plasma etch techniques for fabricating silicon structures from a substrate
US6309828B1 (en) 1998-11-18 2001-10-30 Agilent Technologies, Inc. Method and apparatus for fabricating replicate arrays of nucleic acid molecules
GB9900298D0 (en) 1999-01-07 1999-02-24 Medical Res Council Optical sorting method
US6376246B1 (en) 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
WO2000042559A1 (en) 1999-01-18 2000-07-20 Maxygen, Inc. Methods of populating data structures for use in evolutionary simulations
EP2253704B1 (en) 1999-01-19 2015-08-19 Codexis Mayflower Holdings, LLC Oligonucleotide mediated nucleic acid recombination
US20070065838A1 (en) 1999-01-19 2007-03-22 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6251685B1 (en) 1999-02-18 2001-06-26 Agilent Technologies, Inc. Readout method for molecular biological electronically addressable arrays
CA2362939C (en) 1999-02-19 2010-07-27 Febit Ferrarius Biotechnology Gmbh Method for producing polymers
ATE556149T1 (en) 1999-02-23 2012-05-15 Caliper Life Sciences Inc MANIPULATION OF MICROPARTICLES IN MICROFLUIDIC SYSTEMS
JP2002538790A (en) 1999-03-08 2002-11-19 プロトジーン・ラボラトリーズ・インコーポレーテッド Methods and compositions for economically synthesizing and assembling long DNA sequences
US6824866B1 (en) 1999-04-08 2004-11-30 Affymetrix, Inc. Porous silica substrates for polymer synthesis and assays
US6284465B1 (en) 1999-04-15 2001-09-04 Agilent Technologies, Inc. Apparatus, systems and method for locating nucleic acids bound to surfaces
US6469156B1 (en) 1999-04-20 2002-10-22 The United States Of America As Represented By The Department Of Health And Human Services Rapid and sensitive method for detecting histoplasma capsulatum
US6773676B2 (en) 1999-04-27 2004-08-10 Agilent Technologies, Inc. Devices for performing array hybridization assays and methods of using the same
US6518056B2 (en) 1999-04-27 2003-02-11 Agilent Technologies Inc. Apparatus, systems and method for assaying biological materials using an annular format
US6221653B1 (en) 1999-04-27 2001-04-24 Agilent Technologies, Inc. Method of performing array-based hybridization assays using thermal inkjet deposition of sample fluids
US6300137B1 (en) 1999-04-28 2001-10-09 Agilent Technologies Inc. Method for synthesizing a specific, surface-bound polymer uniformly over an element of a molecular array
US6242266B1 (en) 1999-04-30 2001-06-05 Agilent Technologies Inc. Preparation of biopolymer arrays
US7276336B1 (en) 1999-07-22 2007-10-02 Agilent Technologies, Inc. Methods of fabricating an addressable array of biopolymer probes
US6323043B1 (en) 1999-04-30 2001-11-27 Agilent Technologies, Inc. Fabricating biopolymer arrays
CA2368679C (en) 1999-05-01 2010-11-09 Qinetiq Limited Derivatized porous silicon
EP1242618B1 (en) 1999-05-06 2006-12-06 Mount Sinai School of Medicine of New York University DNA-based steganography
US7056661B2 (en) 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
CA2375060A1 (en) 1999-05-24 2000-11-30 Invitrogen Corporation Method for deblocking of labeled oligonucleotides
US6472147B1 (en) 1999-05-25 2002-10-29 The Scripps Research Institute Methods for display of heterodimeric proteins on filamentous phage using pVII and pIX, compositions, vectors and combinatorial libraries
US6132997A (en) 1999-05-28 2000-10-17 Agilent Technologies Method for linear mRNA amplification
US6815218B1 (en) 1999-06-09 2004-11-09 Massachusetts Institute Of Technology Methods for manufacturing bioelectronic devices
US6709852B1 (en) 1999-06-22 2004-03-23 Invitrogen Corporation Rapid growing microorganisms for biotechnology applications
WO2000079009A2 (en) 1999-06-22 2000-12-28 Invitrogen Corporation Improved primers and methods for the detection and discrimination of nucleic acids
DE19928410C2 (en) 1999-06-22 2002-11-28 Agilent Technologies Inc Device housing with a device for operating a laboratory microchip
US6399394B1 (en) 1999-06-30 2002-06-04 Agilent Technologies, Inc. Testing multiple fluid samples with multiple biopolymer arrays
US6465183B2 (en) 1999-07-01 2002-10-15 Agilent Technologies, Inc. Multidentate arrays
US7504213B2 (en) 1999-07-09 2009-03-17 Agilent Technologies, Inc. Methods and apparatus for preparing arrays comprising features having degenerate biopolymers
US6461816B1 (en) 1999-07-09 2002-10-08 Agilent Technologies, Inc. Methods for controlling cross-hybridization in analysis of nucleic acid sequences
US6306599B1 (en) 1999-07-16 2001-10-23 Agilent Technologies Inc. Biopolymer arrays and their fabrication
US6346423B1 (en) 1999-07-16 2002-02-12 Agilent Technologies, Inc. Methods and compositions for producing biopolymeric arrays
US6201112B1 (en) 1999-07-22 2001-03-13 Agilent Technologies Inc. Method for 3′ end-labeling ribonucleic acids
US6180351B1 (en) 1999-07-22 2001-01-30 Agilent Technologies Inc. Chemical array fabrication with identifier
CA2382157C (en) 1999-08-18 2012-04-03 Illumina, Inc. Compositions and methods for preparing oligonucleotide solutions
US6262490B1 (en) 1999-11-05 2001-07-17 Advanced Semiconductor Engineering, Inc. Substrate strip for use in packaging semiconductor chips
US6743585B2 (en) 1999-09-16 2004-06-01 Agilent Technologies, Inc. Methods for preparing conjugates
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US6319674B1 (en) 1999-09-16 2001-11-20 Agilent Technologies, Inc. Methods for attaching substances to surfaces
US7211390B2 (en) 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7078167B2 (en) 1999-09-17 2006-07-18 Agilent Technologies, Inc. Arrays having background features and methods for using the same
US7122303B2 (en) 1999-09-17 2006-10-17 Agilent Technologies, Inc. Arrays comprising background features that provide for a measure of a non-specific binding and methods for using the same
WO2001023610A2 (en) 1999-09-29 2001-04-05 Solexa Ltd. Polynucleotide sequencing
DE19947495C2 (en) 1999-10-01 2003-05-28 Agilent Technologies Inc Microfluidic microchip
AU1075701A (en) 1999-10-08 2001-04-23 Protogene Laboratories, Inc. Method and apparatus for performing large numbers of reactions using array assembly
US6232072B1 (en) 1999-10-15 2001-05-15 Agilent Technologies, Inc. Biopolymer array inspection
US6451998B1 (en) 1999-10-18 2002-09-17 Agilent Technologies, Inc. Capping and de-capping during oligonucleotide synthesis
US6171797B1 (en) 1999-10-20 2001-01-09 Agilent Technologies Inc. Methods of making polymeric arrays
US6387636B1 (en) 1999-10-22 2002-05-14 Agilent Technologies, Inc. Method of shielding biosynthesis reactions from the ambient environment on an array
US7115423B1 (en) 1999-10-22 2006-10-03 Agilent Technologies, Inc. Fluidic structures within an array package
US6077674A (en) 1999-10-27 2000-06-20 Agilent Technologies Inc. Method of producing oligonucleotide arrays with features of high purity
US8268605B2 (en) 1999-10-29 2012-09-18 Agilent Technologies, Inc. Compositions and methods utilizing DNA polymerases
US20010055761A1 (en) 1999-10-29 2001-12-27 Agilent Technologies Small scale dna synthesis using polymeric solid support with functionalized regions
US6329210B1 (en) 1999-10-29 2001-12-11 Agilent Technologies, Inc. Method and apparatus for high volume polymer synthesis
US6406849B1 (en) 1999-10-29 2002-06-18 Agilent Technologies, Inc. Interrogating multi-featured arrays
US6689319B1 (en) 1999-10-29 2004-02-10 Agilent Technologies, Ind. Apparatus for deposition and inspection of chemical and biological fluids
US6428957B1 (en) 1999-11-08 2002-08-06 Agilent Technologies, Inc. Systems tools and methods of assaying biological materials using spatially-addressable arrays
US6440669B1 (en) 1999-11-10 2002-08-27 Agilent Technologies, Inc. Methods for applying small volumes of reagents
US7041445B2 (en) 1999-11-15 2006-05-09 Clontech Laboratories, Inc. Long oligonucleotide arrays
US6446642B1 (en) 1999-11-22 2002-09-10 Agilent Technologies, Inc. Method and apparatus to clean an inkjet reagent deposition device
US6582938B1 (en) 2001-05-11 2003-06-24 Affymetrix, Inc. Amplification of nucleic acids
US6800439B1 (en) 2000-01-06 2004-10-05 Affymetrix, Inc. Methods for improved array preparation
JP2003519495A (en) 2000-01-11 2003-06-24 マキシジェン， インコーポレイテッド Integrated systems and methods for diversity generation and screening
EP1118661A1 (en) 2000-01-13 2001-07-25 Het Nederlands Kanker Instituut T cell receptor libraries
AU2001237965A1 (en) 2000-01-25 2001-08-07 Affymetrix, Inc. Method, system and computer software for providing a genomic web portal
US6587579B1 (en) 2000-01-26 2003-07-01 Agilent Technologies Inc. Feature quality in array fabrication
US6406851B1 (en) 2000-01-28 2002-06-18 Agilent Technologies, Inc. Method for coating a substrate quickly and uniformly with a small volume of fluid
US6458526B1 (en) 2000-01-28 2002-10-01 Agilent Technologies, Inc. Method and apparatus to inhibit bubble formation in a fluid
US7198939B2 (en) 2000-01-28 2007-04-03 Agilent Technologies, Inc. Apparatus for interrogating an addressable array
US6235483B1 (en) 2000-01-31 2001-05-22 Agilent Technologies, Inc. Methods and kits for indirect labeling of nucleic acids
GB0002389D0 (en) 2000-02-02 2000-03-22 Solexa Ltd Molecular arrays
US6403314B1 (en) 2000-02-04 2002-06-11 Agilent Technologies, Inc. Computational method and system for predicting fragmented hybridization and for identifying potential cross-hybridization
US6833450B1 (en) 2000-03-17 2004-12-21 Affymetrix, Inc. Phosphite ester oxidation in nucleic acid array preparation
US6365355B1 (en) 2000-03-28 2002-04-02 The Regents Of The University Of California Chimeric proteins for detection and quantitation of DNA mutations, DNA sequence variations, DNA damage and DNA mismatches
US20020025561A1 (en) 2000-04-17 2002-02-28 Hodgson Clague Pitman Vectors for gene-self-assembly
US7776021B2 (en) 2000-04-28 2010-08-17 The Charles Stark Draper Laboratory Micromachined bilayer unit for filtration of small molecules
US7163660B2 (en) 2000-05-31 2007-01-16 Infineon Technologies Ag Arrangement for taking up liquid analytes
US6716634B1 (en) 2000-05-31 2004-04-06 Agilent Technologies, Inc. Increasing ionization efficiency in mass spectrometry
US6664112B2 (en) 2000-06-02 2003-12-16 Blue Heron Biotechnology, Inc. Methods for improving the sequence fidelity of synthetic double-stranded oligonucleotides
US7399599B2 (en) 2000-07-10 2008-07-15 Vertex Pharmaceuticals (San Diego) Llc Ion channel assay methods
NZ523715A (en) 2000-07-27 2004-07-30 Univ Australian A set of oligonucleotide probes 'promiscuous' probes that hybridise to target sequences common to more than one of the target polynucleotides
EP1176151B1 (en) 2000-07-28 2014-08-20 Agilent Technologies, Inc. Synthesis of polynucleotides using combined oxidation/deprotection chemistry
US6613893B1 (en) 2000-07-31 2003-09-02 Agilent Technologies Inc. Array fabrication
DE60114525T2 (en) 2000-07-31 2006-07-20 Agilent Technologies Inc., A Delaware Corp., Palo Alto Array-based methods for the synthesis of nucleic acid mixtures
US6890760B1 (en) 2000-07-31 2005-05-10 Agilent Technologies, Inc. Array fabrication
US6599693B1 (en) 2000-07-31 2003-07-29 Agilent Technologies Inc. Array fabrication
US7205400B2 (en) 2000-07-31 2007-04-17 Agilent Technologies, Inc. Array fabrication
GB0018876D0 (en) 2000-08-01 2000-09-20 Applied Research Systems Method of producing polypeptides
AU2001284997A1 (en) 2000-08-24 2002-03-04 Maxygen, Inc. Constructs and their use in metabolic pathway engineering
JP2004507565A (en) 2000-09-08 2004-03-11 ユニバーシティー・テクノロジーズ・インターナショナル・インコーポレイテッド Linker phosphoramidites for oligonucleotide synthesis
US6966945B1 (en) 2000-09-20 2005-11-22 Goodrich Corporation Inorganic matrix compositions, composites and process of making the same
AU2001293163A1 (en) 2000-09-27 2002-04-08 Lynx Therapeutics, Inc. Method for determining relative abundance of nucleic acid sequences
NO20004869D0 (en) 2000-09-28 2000-09-28 Torbjoern Rognes Method for fast optimal local sequence alignment using parallel processing
US7097809B2 (en) 2000-10-03 2006-08-29 California Institute Of Technology Combinatorial synthesis system
AU2001296809A1 (en) 2000-10-10 2002-04-22 Biotrove, Inc. Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof
US6693187B1 (en) 2000-10-17 2004-02-17 Lievre Cornu Llc Phosphinoamidite carboxlates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge
DE10051396A1 (en) 2000-10-17 2002-04-18 Febit Ferrarius Biotech Gmbh An integrated synthesis and identification of an analyte, comprises particles immobilized at a carrier to be coupled to receptors in a structured pattern to give receptor arrays for biochemical reactions
SK287998B6 (en) 2000-10-18 2012-09-03 Ultra Proizvodnja Elektronskih Naprav D. O. O. System for payment data exchange and payment terminal device used therein
EP1203945B1 (en) 2000-10-26 2006-12-20 Agilent Technologies, Inc. (a Delaware corporation) Microarray
US6905816B2 (en) 2000-11-27 2005-06-14 Intelligent Medical Devices, Inc. Clinically intelligent diagnostic devices and methods
US20020155439A1 (en) 2000-12-04 2002-10-24 Ana Rodriguez Method for generating a library of mutant oligonucleotides using the linear cyclic amplification reaction
US6768005B2 (en) 2000-12-20 2004-07-27 Avecia Limited Process
WO2002046205A2 (en) 2000-12-05 2002-06-13 Avecia Limited Process for the preparation of phosphorothionate oligonucleotides
DE10060433B4 (en) 2000-12-05 2006-05-11 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Method for producing a fluid component, fluid component and analysis device
US20040253242A1 (en) 2000-12-05 2004-12-16 Bowdish Katherine S. Rationally designed antibodies
US6660475B2 (en) 2000-12-15 2003-12-09 New England Biolabs, Inc. Use of site-specific nicking endonucleases to create single-stranded regions and applications thereof
AUPR259301A0 (en) 2001-01-18 2001-02-15 Polymerat Pty Ltd Polymers having co-continuous architecture
DK1385950T3 (en) 2001-01-19 2008-11-03 Centocor Inc Computer controlled assembly of a polynucleotide encoding a target polypeptide
US6958217B2 (en) 2001-01-24 2005-10-25 Genomic Expression Aps Single-stranded polynucleotide tags
US6879915B2 (en) 2001-01-31 2005-04-12 Agilent Technologies, Inc. Chemical array fabrication and use
US7027930B2 (en) 2001-01-31 2006-04-11 Agilent Technologies, Inc. Reading chemical arrays
US7166258B2 (en) 2001-01-31 2007-01-23 Agilent Technologies, Inc. Automation-optimized microarray package
US20020164824A1 (en) 2001-02-16 2002-11-07 Jianming Xiao Method and apparatus based on bundled capillaries for high throughput screening
US6660338B1 (en) 2001-03-08 2003-12-09 Agilent Technologies, Inc. Functionalization of substrate surfaces with silane mixtures
CA2468425A1 (en) 2001-03-08 2003-09-19 Applera Corporation Reagents for oligonucleotide cleavage and deprotection
US7211654B2 (en) 2001-03-14 2007-05-01 Regents Of The University Of Michigan Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
DK1370690T3 (en) 2001-03-16 2012-07-09 Kalim Mir Arrays and methods for using them
US6610978B2 (en) 2001-03-27 2003-08-26 Agilent Technologies, Inc. Integrated sample preparation, separation and introduction microdevice for inductively coupled plasma mass spectrometry
WO2002078947A1 (en) 2001-04-02 2002-10-10 Prolinx Incorporated Sensor surfaces for detecting analytes
US20030022240A1 (en) 2001-04-17 2003-01-30 Peizhi Luo Generation and affinity maturation of antibody library in silico
US6943036B2 (en) 2001-04-30 2005-09-13 Agilent Technologies, Inc. Error detection in chemical array fabrication
JP2004530879A (en) 2001-05-03 2004-10-07 シグマ−ジェノシス リミテッド How to build a protein microarray
CA2447240C (en) 2001-05-18 2013-02-19 Wisconsin Alumni Research Foundation Method for the synthesis of dna sequences
US20040175710A1 (en) 2001-05-22 2004-09-09 Haushalter Robert C. Method for in situ, on-chip chemical synthesis
US6880576B2 (en) 2001-06-07 2005-04-19 Nanostream, Inc. Microfluidic devices for methods development
US6649348B2 (en) 2001-06-29 2003-11-18 Agilent Technologies Inc. Methods for manufacturing arrays
US6613523B2 (en) 2001-06-29 2003-09-02 Agilent Technologies, Inc. Method of DNA sequencing using cleavable tags
US20040161741A1 (en) 2001-06-30 2004-08-19 Elazar Rabani Novel compositions and processes for analyte detection, quantification and amplification
US6989267B2 (en) 2001-07-02 2006-01-24 Agilent Technologies, Inc. Methods of making microarrays with substrate surfaces having covalently bound polyelectrolyte films
US6753145B2 (en) 2001-07-05 2004-06-22 Agilent Technologies, Inc. Buffer composition and method for hybridization of microarrays on adsorbed polymer siliceous surfaces
US7205399B1 (en) 2001-07-06 2007-04-17 Sirna Therapeutics, Inc. Methods and reagents for oligonucleotide synthesis
US7314599B2 (en) 2001-07-17 2008-01-01 Agilent Technologies, Inc. Paek embossing and adhesion for microfluidic devices
US6702256B2 (en) 2001-07-17 2004-03-09 Agilent Technologies, Inc. Flow-switching microdevice
US7128876B2 (en) 2001-07-17 2006-10-31 Agilent Technologies, Inc. Microdevice and method for component separation in a fluid
US20030108903A1 (en) 2001-07-19 2003-06-12 Liman Wang Multiple word DNA computing on surfaces
US8067556B2 (en) 2001-07-26 2011-11-29 Agilent Technologies, Inc. Multi-site mutagenesis
WO2003014325A2 (en) 2001-08-10 2003-02-20 Xencor Protein design automation for protein libraries
US7371580B2 (en) 2001-08-24 2008-05-13 Agilent Technologies, Inc. Use of unstructured nucleic acids in assaying nucleic acid molecules
US6682702B2 (en) 2001-08-24 2004-01-27 Agilent Technologies, Inc. Apparatus and method for simultaneously conducting multiple chemical reactions
JP2003101204A (en) 2001-09-25 2003-04-04 Nec Kansai Ltd Wiring substrate, method of manufacturing the same, and electronic component
US20050124022A1 (en) 2001-10-30 2005-06-09 Maithreyan Srinivasan Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US6852850B2 (en) 2001-10-31 2005-02-08 Agilent Technologies, Inc. Use of ionic liquids for fabrication of polynucleotide arrays
US7524950B2 (en) 2001-10-31 2009-04-28 Agilent Technologies, Inc. Uses of cationic salts for polynucleotide synthesis
US6858720B2 (en) 2001-10-31 2005-02-22 Agilent Technologies, Inc. Method of synthesizing polynucleotides using ionic liquids
WO2003040410A1 (en) 2001-11-02 2003-05-15 Nimblegen Systems, Inc. Detection of hybridization oligonucleotide microarray through covalently labeling microarray probe
US7195872B2 (en) 2001-11-09 2007-03-27 3D Biosurfaces, Inc. High surface area substrates for microarrays and methods to make same
US7482118B2 (en) 2001-11-15 2009-01-27 Third Wave Technologies, Inc. Endonuclease-substrate complexes
DE50114507D1 (en) 2001-11-22 2009-01-02 Sloning Biotechnology Gmbh Nucleic acid linkers and their use in gene synthesis
US20030099952A1 (en) 2001-11-26 2003-05-29 Roland Green Microarrays with visible pattern detection
AU2002365811A1 (en) 2001-12-03 2003-06-17 Zymogenetics, Inc. Methods for the selection and cloning of nucleic acid molecules free of unwanted nucleotide sequence alterations
US6927029B2 (en) 2001-12-03 2005-08-09 Agilent Technologies, Inc. Surface with tethered polymeric species for binding biomolecules
US6838888B2 (en) 2001-12-13 2005-01-04 Agilent Technologies, Inc. Flow cell humidity sensor system
WO2003054232A2 (en) 2001-12-13 2003-07-03 Blue Heron Biotechnology, Inc. Methods for removal of double-stranded oligonucleotides containing sequence errors using mismatch recognition proteins
US7932070B2 (en) 2001-12-21 2011-04-26 Agilent Technologies, Inc. High fidelity DNA polymerase compositions and uses therefor
US6846454B2 (en) 2001-12-24 2005-01-25 Agilent Technologies, Inc. Fluid exit in reaction chambers
US7282183B2 (en) 2001-12-24 2007-10-16 Agilent Technologies, Inc. Atmospheric control in reaction chambers
US6790620B2 (en) 2001-12-24 2004-09-14 Agilent Technologies, Inc. Small volume chambers
US7025324B1 (en) 2002-01-04 2006-04-11 Massachusetts Institute Of Technology Gating apparatus and method of manufacture
US20030171325A1 (en) 2002-01-04 2003-09-11 Board Of Regents, The University Of Texas System Proofreading, error deletion, and ligation method for synthesis of high-fidelity polynucleotide sequences
US20040009498A1 (en) 2002-01-14 2004-01-15 Diversa Corporation Chimeric antigen binding molecules and methods for making and using them
JP2005514927A (en) 2002-01-14 2005-05-26 ディヴァーサ コーポレイション Method for producing polynucleotide and method for purifying double-stranded polynucleotide
US6673552B2 (en) 2002-01-14 2004-01-06 Diversa Corporation Methods for purifying annealed double-stranded oligonucleotides lacking base pair mismatches or nucleotide gaps
US7141368B2 (en) 2002-01-30 2006-11-28 Agilent Technologies, Inc. Multi-directional deposition in array fabrication
US7157229B2 (en) 2002-01-31 2007-01-02 Nimblegen Systems, Inc. Prepatterned substrate for optical synthesis of DNA probes
US7422851B2 (en) 2002-01-31 2008-09-09 Nimblegen Systems, Inc. Correction for illumination non-uniformity during the synthesis of arrays of oligomers
US20040126757A1 (en) 2002-01-31 2004-07-01 Francesco Cerrina Method and apparatus for synthesis of arrays of DNA probes
US7037659B2 (en) 2002-01-31 2006-05-02 Nimblegen Systems Inc. Apparatus for constructing DNA probes having a prismatic and kaleidoscopic light homogenizer
US7083975B2 (en) 2002-02-01 2006-08-01 Roland Green Microarray synthesis instrument and method
US20030148291A1 (en) 2002-02-05 2003-08-07 Karla Robotti Method of immobilizing biologically active molecules for assay purposes in a microfluidic format
US6728129B2 (en) 2002-02-19 2004-04-27 The Regents Of The University Of California Multistate triple-decker dyads in three distinct architectures for information storage applications
US6958119B2 (en) 2002-02-26 2005-10-25 Agilent Technologies, Inc. Mobile phase gradient generation microfluidic device
US6770892B2 (en) 2002-02-28 2004-08-03 Agilent Technologies, Inc. Method and system for automated focus-distance determination for molecular array scanners
US6914229B2 (en) 2002-02-28 2005-07-05 Agilent Technologies, Inc. Signal offset for prevention of data clipping in a molecular array scanner
US6929951B2 (en) 2002-02-28 2005-08-16 Agilent Technologies, Inc. Method and system for molecular array scanner calibration
US20050084907A1 (en) 2002-03-01 2005-04-21 Maxygen, Inc. Methods, systems, and software for identifying functional biomolecules
US6919181B2 (en) 2002-03-25 2005-07-19 Agilent Technologies, Inc. Methods for generating ligand arrays
US20030228602A1 (en) 2002-04-01 2003-12-11 Blue Heron Biotechnology, Inc. Solid phase methods for polynucleotide production
EP1350853A1 (en) 2002-04-05 2003-10-08 ID-Lelystad, Instituut voor Dierhouderij en Diergezondheid B.V. Detection of polymorphisms
US6773888B2 (en) 2002-04-08 2004-08-10 Affymetrix, Inc. Photoactivatable silane compounds and methods for their synthesis and use
JP2005523015A (en) 2002-04-22 2005-08-04 ジェネンコー・インターナショナル・インク A method for constructing a library of bacterial clones having various gene expression levels.
GB0209539D0 (en) 2002-04-26 2002-06-05 Avecia Ltd Monomer Polymer and process
US6946285B2 (en) 2002-04-29 2005-09-20 Agilent Technologies, Inc. Arrays with elongated features
US7125523B2 (en) 2002-04-29 2006-10-24 Agilent Technologies, Inc. Holders for arrays
US6621076B1 (en) 2002-04-30 2003-09-16 Agilent Technologies, Inc. Flexible assembly for transporting sample fluids into a mass spectrometer
US7094537B2 (en) 2002-04-30 2006-08-22 Agilent Technologies, Inc. Micro arrays with structured and unstructured probes
AU2003233243A1 (en) 2002-05-06 2003-11-17 Noxxon Pharma Ag Method for amplifying nucleic acids
US20030211478A1 (en) 2002-05-08 2003-11-13 Gentel Corporation Transcription factor profiling on a solid surface
US7221785B2 (en) 2002-05-21 2007-05-22 Agilent Technologies, Inc. Method and system for measuring a molecular array background signal from a continuous background region of specified size
EP1546378B1 (en) 2002-05-24 2011-06-22 Roche NimbleGen, Inc. Microarrays and method for running hybridization reaction for multiple samples on a single microarray
WO2003100019A2 (en) 2002-05-24 2003-12-04 Invitrogen Corporation Nested pcr employing degradable primers
US6789965B2 (en) 2002-05-31 2004-09-14 Agilent Technologies, Inc. Dot printer with off-axis loading
US7537936B2 (en) 2002-05-31 2009-05-26 Agilent Technologies, Inc. Method of testing multiple fluid samples with multiple biopolymer arrays
US7078505B2 (en) 2002-06-06 2006-07-18 Agilent Technologies, Inc. Manufacture of arrays with varying deposition parameters
US7351379B2 (en) 2002-06-14 2008-04-01 Agilent Technologies, Inc. Fluid containment structure
US7371348B2 (en) 2002-06-14 2008-05-13 Agilent Technologies Multiple array format
US7919308B2 (en) 2002-06-14 2011-04-05 Agilent Technologies, Inc. Form in place gaskets for assays
US6939673B2 (en) 2002-06-14 2005-09-06 Agilent Technologies, Inc. Manufacture of arrays with reduced error impact
US7220573B2 (en) 2002-06-21 2007-05-22 Agilent Technologies, Inc. Array assay devices and methods of using the same
US6713262B2 (en) 2002-06-25 2004-03-30 Agilent Technologies, Inc. Methods and compositions for high throughput identification of protein/nucleic acid binding pairs
US7894998B2 (en) 2002-06-26 2011-02-22 Agilent Technologies, Inc. Method for identifying suitable nucleic acid probe sequences for use in nucleic acid arrays
US7202358B2 (en) 2002-07-25 2007-04-10 Agilent Technologies, Inc. Methods for producing ligand arrays
US7452712B2 (en) 2002-07-30 2008-11-18 Applied Biosystems Inc. Sample block apparatus and method of maintaining a microcard on a sample block
US6835938B2 (en) 2002-07-31 2004-12-28 Agilent Technologies, Inc. Biopolymer array substrate thickness dependent automated focus-distance determination method for biopolymer array scanners
US7101508B2 (en) 2002-07-31 2006-09-05 Agilent Technologies, Inc. Chemical array fabrication errors
US7153689B2 (en) 2002-08-01 2006-12-26 Agilent Technologies, Inc. Apparatus and methods for cleaning and priming droplet dispensing devices
US8946387B2 (en) 2002-08-14 2015-02-03 Macrogenics, Inc. FcγRIIB specific antibodies and methods of use thereof
US7205128B2 (en) 2002-08-16 2007-04-17 Agilent Technologies, Inc. Method for synthesis of the second strand of cDNA
US7563600B2 (en) 2002-09-12 2009-07-21 Combimatrix Corporation Microarray synthesis and assembly of gene-length polynucleotides
US20040166567A1 (en) 2002-09-26 2004-08-26 Santi Daniel V Synthetic genes
US7498176B2 (en) 2002-09-27 2009-03-03 Roche Nimblegen, Inc. Microarray with hydrophobic barriers
WO2004031399A2 (en) 2002-09-30 2004-04-15 Nimblegen Systems, Inc. Parallel loading of arrays
WO2004031351A2 (en) 2002-10-01 2004-04-15 Nimblegen Systems, Inc. Microarrays having multiple oligonucleotides in single array features
US7129075B2 (en) 2002-10-18 2006-10-31 Transgenomic, Inc. Isolated CEL II endonuclease
US8283148B2 (en) 2002-10-25 2012-10-09 Agilent Technologies, Inc. DNA polymerase compositions for quantitative PCR and methods thereof
US20070059692A1 (en) 2002-10-28 2007-03-15 Xiaolian Gao Array oligomer synthesis and use
US7402279B2 (en) 2002-10-31 2008-07-22 Agilent Technologies, Inc. Device with integrated microfluidic and electronic components
WO2004040295A1 (en) 2002-10-31 2004-05-13 Nanostream, Inc. Parallel detection chromatography systems
US7390457B2 (en) 2002-10-31 2008-06-24 Agilent Technologies, Inc. Integrated microfluidic array device
US7364896B2 (en) 2002-10-31 2008-04-29 Agilent Technologies, Inc. Test strips including flexible array substrates and method of hybridization
US7422911B2 (en) 2002-10-31 2008-09-09 Agilent Technologies, Inc. Composite flexible array substrate having flexible support
US7629120B2 (en) 2002-10-31 2009-12-08 Rice University Method for assembling PCR fragments of DNA
US20040086892A1 (en) 2002-11-06 2004-05-06 Crothers Donald M. Universal tag assay
US7029854B2 (en) 2002-11-22 2006-04-18 Agilent Technologies, Inc. Methods designing multiple mRNA transcript nucleic acid probe sequences for use in nucleic acid arrays
US7062385B2 (en) 2002-11-25 2006-06-13 Tufts University Intelligent electro-optical nucleic acid-based sensor array and method for detecting volatile compounds in ambient air
ES2347239T3 (en) 2002-12-02 2010-10-27 Amgen Fremont Inc. ANTIBODIES DIRECTED TO THE TUMOR NECROSIS FACTOR AND USES OF THE SAME.
US20040110133A1 (en) 2002-12-06 2004-06-10 Affymetrix, Inc. Functionated photoacid generator for biological microarray synthesis
US7932025B2 (en) 2002-12-10 2011-04-26 Massachusetts Institute Of Technology Methods for high fidelity production of long nucleic acid molecules with error control
US7879580B2 (en) 2002-12-10 2011-02-01 Massachusetts Institute Of Technology Methods for high fidelity production of long nucleic acid molecules
US20060076482A1 (en) 2002-12-13 2006-04-13 Hobbs Steven E High throughput systems and methods for parallel sample analysis
US6987263B2 (en) 2002-12-13 2006-01-17 Nanostream, Inc. High throughput systems and methods for parallel sample analysis
US7247337B1 (en) 2002-12-16 2007-07-24 Agilent Technologies, Inc. Method and apparatus for microarray fabrication
US20040191810A1 (en) 2002-12-17 2004-09-30 Affymetrix, Inc. Immersed microarrays in conical wells
GB0229443D0 (en) 2002-12-18 2003-01-22 Avecia Ltd Process
US7960157B2 (en) 2002-12-20 2011-06-14 Agilent Technologies, Inc. DNA polymerase blends and uses thereof
US8232055B2 (en) 2002-12-23 2012-07-31 Agilent Technologies, Inc. Comparative genomic hybridization assays using immobilized oligonucleotide features and compositions for practicing the same
DE10260805A1 (en) 2002-12-23 2004-07-22 Geneart Gmbh Method and device for optimizing a nucleotide sequence for expression of a protein
ATE514713T1 (en) 2002-12-23 2011-07-15 Wyeth Llc ANTIBODIES TO PD-1 AND THEIR USE
WO2004058392A2 (en) 2002-12-23 2004-07-15 Febit Ag Intramolecular triplet-sensitized o-nitrophenylethyl photoprotective groups
US7372982B2 (en) 2003-01-14 2008-05-13 Agilent Technologies, Inc. User interface for molecular array feature analysis
US6809277B2 (en) 2003-01-22 2004-10-26 Agilent Technologies, Inc. Method for registering a deposited material with channel plate channels, and switch produced using same
CN101128601B (en) 2003-01-29 2011-06-08 454生命科学公司 Methods of amplifying and sequencing nucleic acids
US8073626B2 (en) 2003-01-31 2011-12-06 Agilent Technologies, Inc. Biopolymer array reading
US7202264B2 (en) 2003-01-31 2007-04-10 Isis Pharmaceuticals, Inc. Supports for oligomer synthesis
US6950756B2 (en) 2003-02-05 2005-09-27 Agilent Technologies, Inc. Rearrangement of microarray scan images to form virtual arrays
GB2398383B (en) 2003-02-12 2005-03-09 Global Genomics Ab Method and means for nucleic acid sequencing
US7413709B2 (en) 2003-02-12 2008-08-19 Agilent Technologies, Inc. PAEK-based microfluidic device with integrated electrospray emitter
US7244513B2 (en) 2003-02-21 2007-07-17 Nano-Proprietary, Inc. Stain-etched silicon powder
US7070932B2 (en) 2003-02-25 2006-07-04 Agilent Technologies, Inc. Methods and devices for detecting printhead misalignment of an in situ polymeric array synthesis device
US7252938B2 (en) 2003-02-25 2007-08-07 Agilent Technologies, Inc. Methods and devices for producing a polymer at a location of a substrate
WO2004080887A1 (en) 2003-03-07 2004-09-23 Massachusetts Institute Of Technology Three dimensional mecrofabrication
US20050053968A1 (en) * 2003-03-31 2005-03-10 Council Of Scientific And Industrial Research Method for storing information in DNA
EP1613776A1 (en) 2003-04-02 2006-01-11 Blue Heron Biotechnology, Inc. Error reduction in automated gene synthesis
US7534561B2 (en) 2003-04-02 2009-05-19 Agilent Technologies, Inc. Nucleic acid array in situ fabrication methods and arrays produced using the same
US7269518B2 (en) 2003-04-30 2007-09-11 Agilent Technologies, Inc. Chemical array reading
US20040219663A1 (en) 2003-04-30 2004-11-04 Page Robert D. Biopolymer array fabrication using different drop deposition heads
US7206439B2 (en) 2003-04-30 2007-04-17 Agilent Technologies, Inc. Feature locations in array reading
US6916113B2 (en) 2003-05-16 2005-07-12 Agilent Technologies, Inc. Devices and methods for fluid mixing
CA2526368A1 (en) 2003-05-20 2004-12-02 Fluidigm Corporation Method and system for microfluidic device and imaging thereof
EP1633889B1 (en) 2003-05-30 2010-09-01 The Board Of Trustees Of The University Of Illinois Gene expression profiles that identify genetically elite ungulate mammals
US7276599B2 (en) 2003-06-02 2007-10-02 Isis Pharmaceuticals, Inc. Oligonucleotide synthesis with alternative solvents
US8133670B2 (en) 2003-06-13 2012-03-13 Cold Spring Harbor Laboratory Method for making populations of defined nucleic acid molecules
US6938476B2 (en) 2003-06-25 2005-09-06 Agilent Technologies, Inc. Apparatus and methods for sensing fluid levels
US7534563B2 (en) 2003-06-30 2009-05-19 Agilent Technologies, Inc. Methods for producing ligand arrays
US20050016851A1 (en) 2003-07-24 2005-01-27 Jensen Klavs F. Microchemical method and apparatus for synthesis and coating of colloidal nanoparticles
US6843281B1 (en) 2003-07-30 2005-01-18 Agilent Techinologies, Inc. Methods and apparatus for introducing liquids into microfluidic chambers
US7353116B2 (en) 2003-07-31 2008-04-01 Agilent Technologies, Inc. Chemical array with test dependent signal reading or processing
US7939310B2 (en) 2003-08-06 2011-05-10 University Of Massachusetts Systems and methods for analyzing nucleic acid sequences
US7028536B2 (en) 2004-06-29 2006-04-18 Nanostream, Inc. Sealing interface for microfluidic device
US7348144B2 (en) 2003-08-13 2008-03-25 Agilent Technologies, Inc. Methods and system for multi-drug treatment discovery
US7229497B2 (en) 2003-08-26 2007-06-12 Massachusetts Institute Of Technology Method of preparing nanocrystals
US7585970B2 (en) 2003-08-30 2009-09-08 Agilent Technologies, Inc. Method of polynucleotide synthesis using modified support
US7385050B2 (en) 2003-08-30 2008-06-10 Agilent Technologies, Inc. Cleavable linker for polynucleotide synthesis
US7417139B2 (en) 2003-08-30 2008-08-26 Agilent Technologies, Inc. Method for polynucleotide synthesis
US7193077B2 (en) 2003-08-30 2007-03-20 Agilent Technologies, Inc. Exocyclic amine triaryl methyl protecting groups in two-step polynucleotide synthesis
US7427679B2 (en) 2003-08-30 2008-09-23 Agilent Technologies, Inc. Precursors for two-step polynucleotide synthesis
US20050049796A1 (en) 2003-09-03 2005-03-03 Webb Peter G. Methods for encoding non-biological information on microarrays
EP2824190A1 (en) 2003-09-09 2015-01-14 Integrigen, Inc. Methods and compositions for generation of germline human antibody genes
JP2007506429A (en) 2003-09-23 2007-03-22 アトム・サイエンシズ・インコーポレーテッド Polymeric nucleic acid hybridization probe
US7488607B2 (en) 2003-09-30 2009-02-10 Agilent Technologies, Inc. Electronically readable microarray with electronic addressing function
US7147362B2 (en) 2003-10-15 2006-12-12 Agilent Technologies, Inc. Method of mixing by intermittent centrifugal force
US7075161B2 (en) 2003-10-23 2006-07-11 Agilent Technologies, Inc. Apparatus and method for making a low capacitance artificial nanopore
US20050277125A1 (en) 2003-10-27 2005-12-15 Massachusetts Institute Of Technology High-density reaction chambers and methods of use
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
US7276338B2 (en) 2003-11-17 2007-10-02 Jacobson Joseph M Nucleotide sequencing via repetitive single molecule hybridization
DE10353887A1 (en) 2003-11-18 2005-06-16 Febit Ag Highly parallel matrix-based DNA synthesizer
US7851192B2 (en) 2004-11-22 2010-12-14 New England Biolabs, Inc. Modified DNA cleavage enzymes and methods for use
US7282705B2 (en) 2003-12-19 2007-10-16 Agilent Technologies, Inc. Microdevice having an annular lining for producing an electrospray emitter
ES2949821T3 (en) 2004-01-07 2023-10-03 Illumina Cambridge Ltd Molecular arrays
ES2432040T3 (en) 2004-01-28 2013-11-29 454 Life Sciences Corporation Nucleic acid amplification with continuous flow emulsion
US7084180B2 (en) 2004-01-28 2006-08-01 Velocys, Inc. Fischer-tropsch synthesis using microchannel technology and novel catalyst and microchannel reactor
US7125488B2 (en) 2004-02-12 2006-10-24 Varian, Inc. Polar-modified bonded phase materials for chromatographic separations
WO2005080604A2 (en) 2004-02-12 2005-09-01 Compass Genetics, Llc Genetic analysis by sequence-specific sorting
EP1733055A4 (en) 2004-02-27 2009-03-11 Harvard College Polynucleotide synthesis
WO2005093092A2 (en) 2004-03-26 2005-10-06 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g-protein coupled receptor 44 (gpr44)
US7875463B2 (en) 2004-03-26 2011-01-25 Agilent Technologies, Inc. Generalized pulse jet ejection head control model
US20050214778A1 (en) 2004-03-29 2005-09-29 Peck Bill J Methods for in situ generation of nucleic acid arrays
US20050214779A1 (en) 2004-03-29 2005-09-29 Peck Bill J Methods for in situ generation of nucleic acid arrays
US8825411B2 (en) 2004-05-04 2014-09-02 Dna Twopointo, Inc. Design, synthesis and assembly of synthetic nucleic acids
AU2005280659A1 (en) 2004-05-11 2006-03-09 Wyeth Novel polynucleotides related to oligonucleotide arrays to monitor gene expression
US8318479B2 (en) 2004-05-19 2012-11-27 Massachusetts Institute Of Technology Perfused three-dimensional cell/tissue disease models
US7302348B2 (en) 2004-06-02 2007-11-27 Agilent Technologies, Inc. Method and system for quantifying and removing spatial-intensity trends in microarray data
US20060024711A1 (en) 2004-07-02 2006-02-02 Helicos Biosciences Corporation Methods for nucleic acid amplification and sequence determination
CA2572917C (en) 2004-07-06 2012-04-03 Bioren Inc. Look-through mutagenesis for developing altered polypeptides with enhanced properties
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
US20060012793A1 (en) 2004-07-19 2006-01-19 Helicos Biosciences Corporation Apparatus and methods for analyzing samples
US7276720B2 (en) 2004-07-19 2007-10-02 Helicos Biosciences Corporation Apparatus and methods for analyzing samples
US20060019084A1 (en) 2004-07-23 2006-01-26 Pearson Laurence T Monolithic composition and method
US20060024678A1 (en) 2004-07-28 2006-02-02 Helicos Biosciences Corporation Use of single-stranded nucleic acid binding proteins in sequencing
CA2575490A1 (en) 2004-08-03 2006-02-16 Frank Notka Method for modulating gene expression by altering the cpg content
WO2006073504A2 (en) 2004-08-04 2006-07-13 President And Fellows Of Harvard College Wobble sequencing
WO2006018044A1 (en) 2004-08-18 2006-02-23 Agilent Technologies, Inc. Microfluidic assembly with coupled microfluidic devices
US7034290B2 (en) 2004-09-24 2006-04-25 Agilent Technologies, Inc. Target support with pattern recognition sites
US7943046B2 (en) 2004-10-01 2011-05-17 Agilent Technologies, Inc Methods and systems for on-column protein delipidation
CA2584984A1 (en) 2004-10-18 2006-04-27 Codon Devices, Inc. Methods for assembly of high fidelity synthetic polynucleotides
US20070122817A1 (en) 2005-02-28 2007-05-31 George Church Methods for assembly of high fidelity synthetic polynucleotides
US7141807B2 (en) 2004-10-22 2006-11-28 Agilent Technologies, Inc. Nanowire capillaries for mass spectrometry
US20060110744A1 (en) 2004-11-23 2006-05-25 Sampas Nicolas M Probe design methods and microarrays for comparative genomic hybridization and location analysis
US8380441B2 (en) 2004-11-30 2013-02-19 Agilent Technologies, Inc. Systems for producing chemical array layouts
US11268149B2 (en) 2004-12-08 2022-03-08 Cedars-Sinai Medical Center Diagnosis and treatment of inflammatory bowel disease
US7977119B2 (en) 2004-12-08 2011-07-12 Agilent Technologies, Inc. Chemical arrays and methods of using the same
US7439272B2 (en) 2004-12-20 2008-10-21 Varian, Inc. Ultraporous sol gel monoliths
EP1841788A4 (en) 2004-12-22 2009-01-21 Univ Singapore Novel snake toxin
EP1838870A2 (en) 2004-12-29 2007-10-03 Exiqon A/S NOVEL OLIGONUCLEOTIDE COMPOSITIONS AND PROBE SEQUENCES USEFUL FOR DETECTION AND ANALYSIS OF MICRORNAS AND THEIR TARGET MRNAs
WO2006076679A1 (en) 2005-01-13 2006-07-20 Codon Devices, Inc. Compositions and methods for protein design
US20060171855A1 (en) 2005-02-03 2006-08-03 Hongfeng Yin Devices,systems and methods for multi-dimensional separation
US20090088679A1 (en) 2005-02-07 2009-04-02 Massachusetts Institute Of Technology Electronically-Degradable Layer-by-Layer Thin Films
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
JP4641199B2 (en) 2005-02-28 2011-03-02 国立感染症研究所長 Apparatus for designing RNA interference polynucleotide mixture, method for producing RNA interference polynucleotide mixture, and program for designing RNA interference polynucleotide mixture
US20060203236A1 (en) 2005-03-08 2006-09-14 Zhenghua Ji Sample cell
EP1623763A1 (en) 2005-03-11 2006-02-08 Agilent Technologies, Inc. Chip with cleaning cavity
US7618777B2 (en) 2005-03-16 2009-11-17 Agilent Technologies, Inc. Composition and method for array hybridization
US20060219637A1 (en) 2005-03-29 2006-10-05 Killeen Kevin P Devices, systems and methods for liquid chromatography
WO2006116476A1 (en) 2005-04-27 2006-11-02 Sigma-Aldrich Co. Activators for oligonucleotide and phosphoramidite synthesis
US7572907B2 (en) 2005-04-29 2009-08-11 Agilent Technologies, Inc. Methods and compounds for polynucleotide synthesis
CA2607532C (en) 2005-04-29 2013-03-12 The J. Craig Venter Institute Amplification and cloning of single dna molecules using rolling circle amplification
US8945680B2 (en) 2005-05-12 2015-02-03 Hempel A/S Method for the establishment of a crack resistant epoxy paint coat and paint compositions suitable for said method
US7396676B2 (en) 2005-05-31 2008-07-08 Agilent Technologies, Inc. Evanescent wave sensor with attached ligand
DK1907583T4 (en) 2005-06-15 2020-01-27 Complete Genomics Inc SINGLE MOLECULE ARRAYS FOR GENETIC AND CHEMICAL ANALYSIS
US7919239B2 (en) 2005-07-01 2011-04-05 Agilent Technologies, Inc. Increasing hybridization efficiencies
US8076064B2 (en) 2005-07-09 2011-12-13 Agilent Technologies, Inc. Method of treatment of RNA sample
US7718365B2 (en) 2005-07-09 2010-05-18 Agilent Technologies, Inc. Microarray analysis of RNA
EP1924704B1 (en) 2005-08-02 2011-05-25 Rubicon Genomics, Inc. Compositions and methods for processing and amplification of dna, including using multiple enzymes in a single reaction
DE102005037351B3 (en) 2005-08-08 2007-01-11 Geneart Ag In vitro method for directed evolution of proteins, useful e.g. in pharmaceutical development, uses expression system for performing translation, transcription and reverse transcription
EP1929012B1 (en) 2005-08-11 2010-10-06 Synthetic Genomics, Inc. Method for in vitro recombination
US9404882B2 (en) 2005-08-11 2016-08-02 New Mexico Tech Research Foundation Method of producing a multi-microchannel, flow-through element and device using same
EP1915446B1 (en) 2005-08-11 2017-06-14 Synthetic Genomics, Inc. In vitro recombination method
US7749701B2 (en) 2005-08-11 2010-07-06 Agilent Technologies, Inc. Controlling use of oligonucleotide sequences released from arrays
US7805252B2 (en) 2005-08-16 2010-09-28 Dna Twopointo, Inc. Systems and methods for designing and ordering polynucleotides
US20070054127A1 (en) 2005-08-26 2007-03-08 Hergenrother Robert W Silane coating compositions, coating systems, and methods
US20070196834A1 (en) 2005-09-09 2007-08-23 Francesco Cerrina Method and system for the generation of large double stranded DNA fragments
WO2007032236A1 (en) 2005-09-16 2007-03-22 Yamatake Corporation Substrate for biochip, biochip, method for manufacturing substrate for biochip, and method for manufacturing biochip
US20080308884A1 (en) 2005-10-13 2008-12-18 Silex Microsystems Ab Fabrication of Inlet and Outlet Connections for Microfluidic Chips
US7368550B2 (en) 2005-10-31 2008-05-06 Agilent Technologies, Inc. Phosphorus protecting groups
US8202985B2 (en) 2005-10-31 2012-06-19 Agilent Technologies, Inc. Monomer compositions for the synthesis of polynucleotides, methods of synthesis, and methods of deprotection
US7759471B2 (en) 2005-10-31 2010-07-20 Agilent Technologies, Inc. Monomer compositions for the synthesis of RNA, methods of synthesis, and methods of deprotection
US8552174B2 (en) 2005-10-31 2013-10-08 Agilent Technologies, Inc. Solutions, methods, and processes for deprotection of polynucleotides
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
US7291471B2 (en) 2005-11-21 2007-11-06 Agilent Technologies, Inc. Cleavable oligonucleotide arrays
GB0524069D0 (en) 2005-11-25 2006-01-04 Solexa Ltd Preparation of templates for solid phase amplification
US8137936B2 (en) 2005-11-29 2012-03-20 Macevicz Stephen C Selected amplification of polynucleotides
CN101365803B (en) 2005-12-22 2013-03-20 关键基因股份有限公司 Improved strategies for transcript profiling using high throughput sequencing technologies
EP1989318B1 (en) 2006-01-06 2014-07-30 Agilent Technologies, Inc. Reaction buffer composition for nucleic acid replication with packed dna polymerases
WO2007081387A1 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices, methods of use, and kits for performing diagnostics
WO2007087310A2 (en) 2006-01-23 2007-08-02 Population Genetics Technologies Ltd. Nucleic acid analysis using sequence tokens
US20070207487A1 (en) 2006-01-25 2007-09-06 Emig Christopher J Photoelectrochemical synthesis of high density combinatorial polymer arrays
WO2008057127A2 (en) 2006-02-06 2008-05-15 Massachusetts Institute Of Technology Self-assembly of macromolecules on multilayered polymer surfaces
US8809876B2 (en) 2006-02-14 2014-08-19 Massachusetts Institute Of Technology Absorbing film
US7807356B2 (en) 2006-03-09 2010-10-05 Agilent Technologies, Inc. Labeled nucleotide composition
TW200806317A (en) 2006-03-20 2008-02-01 Wyeth Corp Methods for reducing protein aggregation
US7855281B2 (en) 2006-03-23 2010-12-21 Agilent Technologies, Inc. Cleavable thiocarbonate linkers for polynucleotide synthesis
US7572908B2 (en) 2006-03-23 2009-08-11 Agilent Technologies, Inc. Cleavable linkers for polynucleotides
US20070231800A1 (en) 2006-03-28 2007-10-04 Agilent Technologies, Inc. Determination of methylated DNA
EP3373174A1 (en) 2006-03-31 2018-09-12 Illumina, Inc. Systems and devices for sequence by synthesis analysis
US20070238106A1 (en) 2006-04-07 2007-10-11 Agilent Technologies, Inc. Systems and methods of determining alleles and/or copy numbers
US20070238104A1 (en) 2006-04-07 2007-10-11 Agilent Technologies, Inc. Competitive oligonucleotides
US8058055B2 (en) 2006-04-07 2011-11-15 Agilent Technologies, Inc. High resolution chromosomal mapping
US20070238108A1 (en) 2006-04-07 2007-10-11 Agilent Technologies, Inc. Validation of comparative genomic hybridization
AU2007234733A1 (en) 2006-04-07 2007-10-18 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Antibody compositions and methods for treatment of neoplastic disease
US20100173364A1 (en) 2006-04-11 2010-07-08 New England Biolabs, Inc. Repair of Nucleic Acids for Improved Amplification
CA2649725A1 (en) 2006-04-19 2007-10-25 Applera Corporation Reagents, methods, and libraries for gel-free bead-based sequencing
US8383338B2 (en) 2006-04-24 2013-02-26 Roche Nimblegen, Inc. Methods and systems for uniform enrichment of genomic regions
US20070259346A1 (en) 2006-05-03 2007-11-08 Agilent Technologies, Inc. Analysis of arrays
US20070259344A1 (en) 2006-05-03 2007-11-08 Agilent Technologies, Inc. Compound probes and methods of increasing the effective probe densities of arrays
US20070259345A1 (en) 2006-05-03 2007-11-08 Agilent Technologies, Inc. Target determination using compound probes
US20070259347A1 (en) 2006-05-03 2007-11-08 Agilent Technologies, Inc. Methods of increasing the effective probe densities of arrays
WO2007137242A2 (en) 2006-05-19 2007-11-29 Massachusetts Institute Of Technology Microfluidic-based gene synthesis
US20090087840A1 (en) 2006-05-19 2009-04-02 Codon Devices, Inc. Combined extension and ligation for nucleic acid assembly
WO2008054543A2 (en) 2006-05-20 2008-05-08 Codon Devices, Inc. Oligonucleotides for multiplex nucleic acid assembly
WO2007148337A2 (en) 2006-06-19 2007-12-27 Yeda Research And Development Co. Ltd. Programmable iterated elongation: a method for manufacturing synthetic genes and combinatorial dna and protein libraries
AT503902B1 (en) 2006-07-05 2008-06-15 F Star Biotech Forsch & Entw METHOD FOR MANIPULATING IMMUNE LOBULINS
AT503861B1 (en) 2006-07-05 2008-06-15 F Star Biotech Forsch & Entw METHOD FOR MANIPULATING T-CELL RECEPTORS
US20080193772A1 (en) 2006-07-07 2008-08-14 Bio-Rad Laboratories, Inc Mass spectrometry probes having hydrophobic coatiings
EP2049682A2 (en) 2006-07-31 2009-04-22 Illumina Cambridge Limited Method of library preparation avoiding the formation of adaptor dimers
US7524942B2 (en) 2006-07-31 2009-04-28 Agilent Technologies, Inc. Labeled nucleotide composition
US7572585B2 (en) 2006-07-31 2009-08-11 Agilent Technologies, Inc. Enzymatic labeling of RNA
HUE037173T2 (en) 2006-08-08 2018-08-28 Univ Bonn Rheinische Friedrich Wilhelms Structure and use of 5' phosphate oligonucleotides
DE102006039479A1 (en) 2006-08-23 2008-03-06 Febit Biotech Gmbh Programmable oligonucleotide synthesis
WO2008023179A2 (en) 2006-08-24 2008-02-28 Solexa Limited Method for retaining even coverage of short insert libraries
US8053191B2 (en) 2006-08-31 2011-11-08 Westend Asset Clearinghouse Company, Llc Iterative nucleic acid assembly using activation of vector-encoded traits
US8415138B2 (en) 2006-08-31 2013-04-09 Agilent Technologies, Inc. Apparatuses and methods for oligonucleotide preparation
US8097711B2 (en) 2006-09-02 2012-01-17 Agilent Technologies, Inc. Thioether substituted aryl carbonate protecting groups
US20080311628A1 (en) 2006-10-03 2008-12-18 Ghc Technologies, Inc. Methods and compositions for rapid amplification and capture of nucleic acid sequences
US20080287320A1 (en) 2006-10-04 2008-11-20 Codon Devices Libraries and their design and assembly
US20080085511A1 (en) 2006-10-05 2008-04-10 Peck Bill J Preparation of biopolymer arrays
US20080085514A1 (en) 2006-10-10 2008-04-10 Peck Bill J Methods and devices for array synthesis
JP2008097189A (en) 2006-10-10 2008-04-24 National Institute Of Advanced Industrial & Technology Method for judging transfer object specificity or gene specificity of base sequence fragment
US7867782B2 (en) 2006-10-19 2011-01-11 Agilent Technologies, Inc. Nanoscale moiety placement methods
US7999087B2 (en) 2006-11-15 2011-08-16 Agilent Technologies, Inc. 2′-silyl containing thiocarbonate protecting groups for RNA synthesis
WO2008063134A1 (en) 2006-11-24 2008-05-29 Agency For Science, Technology And Research Method of producing a pattern of discriminative wettability
WO2008063135A1 (en) 2006-11-24 2008-05-29 Agency For Science, Technology And Research Apparatus for processing a sample in a liquid droplet and method of using the same
US8242258B2 (en) 2006-12-03 2012-08-14 Agilent Technologies, Inc. Protecting groups for RNA synthesis
US20080267949A1 (en) 2006-12-05 2008-10-30 Ablynx N.V. Peptides capable of binding to serum proteins
US7989396B2 (en) 2006-12-05 2011-08-02 The Board Of Trustees Of The Leland Stanford Junior University Biomolecule immobilization on biosensors
US7862999B2 (en) 2007-01-17 2011-01-04 Affymetrix, Inc. Multiplex targeted amplification using flap nuclease
US8314220B2 (en) 2007-01-26 2012-11-20 Agilent Technologies, Inc. Methods compositions, and kits for detection of microRNA
US20080182296A1 (en) 2007-01-31 2008-07-31 Chanda Pranab K Pcr-directed gene synthesis from large number of overlapping oligodeoxyribonucleotides
KR100827449B1 (en) 2007-02-07 2008-05-07 삼성전자주식회사 Photolabile compound, oligomer probe array and substrate for oligomer probe array with the same and the method of fabricating the same
WO2008115632A2 (en) 2007-02-09 2008-09-25 The Regents Of The University Of California Method for recombining dna sequences and compositions related thereto
US8603950B2 (en) 2007-02-20 2013-12-10 Anaptysbio, Inc. Methods of generating libraries and uses thereof
WO2008109176A2 (en) 2007-03-07 2008-09-12 President And Fellows Of Harvard College Assays and other reactions involving droplets
US7651762B2 (en) 2007-03-13 2010-01-26 Varian, Inc. Methods and devices using a shrinkable support for porous monolithic materials
CA2684801C (en) 2007-04-04 2017-10-10 The Regents Of The University Of California Compositions, devices, systems, and methods for using a nanopore
HUE028389T2 (en) 2007-05-10 2016-12-28 Agilent Technologies Inc Thiocarbon-protecting groups for RNA synthesis
EP2160472A1 (en) 2007-06-04 2010-03-10 IN Situ RCP A/S Enzyme activity assay using rolling circle amplification
US20080318334A1 (en) 2007-06-20 2008-12-25 Robotti Karla M Microfluidic devices comprising fluid flow paths having a monolithic chromatographic material
US20090023190A1 (en) 2007-06-20 2009-01-22 Kai Qin Lao Sequence amplification with loopable primers
US8194244B2 (en) 2007-06-29 2012-06-05 Intel Corporation Solution sample plate with wells designed for improved Raman scattering signal detection efficiency
US7659069B2 (en) 2007-08-31 2010-02-09 Agilent Technologies, Inc. Binary signaling assay using a split-polymerase
US8685642B2 (en) 2007-07-30 2014-04-01 Agilent Technologies, Inc. Allele-specific copy number measurement using single nucleotide polymorphism and DNA arrays
US7979215B2 (en) 2007-07-30 2011-07-12 Agilent Technologies, Inc. Methods and systems for evaluating CGH candidate probe nucleic acid sequences
US20090036664A1 (en) 2007-07-31 2009-02-05 Brian Jon Peter Complex oligonucleotide primer mix
US20110124049A1 (en) 2007-08-07 2011-05-26 Mo-Huang Li Integrated microfluidic device for gene synthesis
CA2696372C (en) 2007-08-14 2016-09-13 Arcxis Biotechnologies, Inc. Polymer microfluidic biochip fabrication
US20110126929A1 (en) 2007-08-15 2011-06-02 Massachusetts Institute Of Technology Microstructures For Fluidic Ballasting and Flow Control
US9598737B2 (en) 2012-05-09 2017-03-21 Longhorn Vaccines And Diagnostics, Llc Next generation genomic sequencing methods
US20090053704A1 (en) 2007-08-24 2009-02-26 Natalia Novoradovskaya Stabilization of nucleic acids on solid supports
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
EP2198000A4 (en) 2007-09-17 2013-02-20 Supramolecular nanostamping printing device
US7790387B2 (en) 2007-09-24 2010-09-07 Agilent Technologies, Inc. Thiocarbonate linkers for polynucleotides
AU2008307617B2 (en) 2007-09-28 2013-05-23 Pacific Biosciences Of California, Inc. Error-free amplification of DNA for clonal sequencing
EP2053132A1 (en) 2007-10-23 2009-04-29 Roche Diagnostics GmbH Enrichment and sequence analysis of geomic regions
US8617811B2 (en) 2008-01-28 2013-12-31 Complete Genomics, Inc. Methods and compositions for efficient base calling in sequencing reactions
WO2009070665A1 (en) 2007-11-27 2009-06-04 Massachusetts Institute Of Technology Near field detector for integrated surface plasmon resonance biosensor applications
WO2009076580A2 (en) 2007-12-12 2009-06-18 Thomas Jefferson University Compositions and methods for the treatment and prevention of cardiovascular diseases
US9286439B2 (en) 2007-12-17 2016-03-15 Yeda Research And Development Co Ltd System and method for editing and manipulating DNA
US9540637B2 (en) 2008-01-09 2017-01-10 Life Technologies Corporation Nucleic acid adaptors and uses thereof
WO2009089384A1 (en) 2008-01-09 2009-07-16 Life Technologies Method of making a paired tag library for nucleic acid sequencing
US7682809B2 (en) 2008-01-11 2010-03-23 Agilent Technologies, Inc. Direct ATP release sequencing
EP2238459B1 (en) 2008-01-23 2019-05-08 Roche Diagnostics GmbH Integrated instrument performing synthesis and amplification
WO2009131724A2 (en) 2008-01-24 2009-10-29 Massachusetts Institute Of Technology Insulated nanogap devices and methods of use thereof
US20090194483A1 (en) 2008-01-31 2009-08-06 Robotti Karla M Microfluidic device having monolithic separation medium and method of use
WO2009103027A2 (en) 2008-02-15 2009-08-20 Synthetic Genomics, Inc. Methods for in vitro joining and combinatorial assembly of nucleic acid molecules
WO2009113709A1 (en) 2008-03-11 2009-09-17 国立大学法人東京大学 Method of preparing dna fragment having sticky end
US20090230044A1 (en) 2008-03-13 2009-09-17 Agilent Technologies, Inc. Microfluid Chip Cleaning
US20090238722A1 (en) 2008-03-18 2009-09-24 Agilent Technologies, Inc. Pressure-Reinforced Fluidic Chip
US8906831B2 (en) 2008-03-31 2014-12-09 Pacific Biosciences Of California, Inc. Single molecule loading methods and compositions
US20090246788A1 (en) 2008-04-01 2009-10-01 Roche Nimblegen, Inc. Methods and Assays for Capture of Nucleic Acids
US8911948B2 (en) 2008-04-30 2014-12-16 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
EP2113255A1 (en) 2008-05-02 2009-11-04 f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. Cytotoxic immunoglobulin
JP4582224B2 (en) 2008-05-02 2010-11-17 ソニー株式会社 Microbead manufacturing method and microbead
JP5592357B2 (en) 2008-05-27 2014-09-17 ダコ・デンマーク・エー／エス Compositions and methods for detection of chromosomal abnormalities using novel hybridization buffers
TWI466684B (en) 2008-06-30 2015-01-01 Morphotek Inc Anti-gd2 antibodies and methods and uses related thereto
GB2461546B (en) 2008-07-02 2010-07-07 Argen X Bv Antigen binding polypeptides
JP4667490B2 (en) 2008-07-09 2011-04-13 三菱電機株式会社 Cooker
WO2010014903A1 (en) 2008-07-31 2010-02-04 Massachusetts Institute Of Technology Multiplexed olfactory receptor-based microsurface plasmon polariton detector
US20100069250A1 (en) 2008-08-16 2010-03-18 The Board Of Trustees Of The Leland Stanford Junior University Digital PCR Calibration for High Throughput Sequencing
CA2734235C (en) 2008-08-22 2019-03-26 Sangamo Biosciences, Inc. Methods and compositions for targeted single-stranded cleavage and targeted integration
WO2010025310A2 (en) 2008-08-27 2010-03-04 Westend Asset Clearinghouse Company, Llc Methods and devices for high fidelity polynucleotide synthesis
US8034917B2 (en) 2008-08-28 2011-10-11 Agilent Technologies, Inc. Primer-directed chromosome painting
CN102159726A (en) 2008-09-05 2011-08-17 生命科技公司 Methods and systems for nucleic acid sequencing validation, calibration and normalization
US8586310B2 (en) 2008-09-05 2013-11-19 Washington University Method for multiplexed nucleic acid patch polymerase chain reaction
CA2772434C (en) 2008-09-05 2017-11-21 Masad Damha Rna monomers containing o-acetal levulinyl ester groups and their use in rna microarrays
WO2010027512A2 (en) 2008-09-06 2010-03-11 Chemgenes Corporation Rna synthesis - phosphoramidites for synthetic rna in the reverse direction, and application in convenient introduction of ligands, chromophores and modifications of synthetic rna at the 3' - end
US8541569B2 (en) 2008-09-06 2013-09-24 Chemgenes Corporation Phosphoramidites for synthetic RNA in the reverse direction, efficient RNA synthesis and convenient introduction of 3'-end ligands, chromophores and modifications of synthetic RNA
CN102124112B (en) 2008-09-10 2013-03-20 金斯瑞公司 Homologous recombination-based DNA cloning methods and compositions
US20100076183A1 (en) 2008-09-22 2010-03-25 Dellinger Douglas J Protected monomer and method of final deprotection for rna synthesis
US8213015B2 (en) 2008-09-25 2012-07-03 Agilent Technologies, Inc. Integrated flow cell with semiconductor oxide tubing
AU2009298501A1 (en) 2008-09-30 2010-04-08 Abbvie Inc. Improved antibody libraries
US20100090341A1 (en) 2008-10-14 2010-04-15 Molecular Imprints, Inc. Nano-patterned active layers formed by nano-imprint lithography
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US9080211B2 (en) 2008-10-24 2015-07-14 Epicentre Technologies Corporation Transposon end compositions and methods for modifying nucleic acids
US8357489B2 (en) 2008-11-13 2013-01-22 The Board Of Trustees Of The Leland Stanford Junior University Methods for detecting hepatocellular carcinoma
WO2010062960A2 (en) 2008-11-26 2010-06-03 Cedars-Sinai Medical Center METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE
EP2370451B1 (en) 2008-12-02 2016-11-16 Wave Life Sciences Japan, Inc. Method for the synthesis of phosphorus atom modified nucleic acids
US8963262B2 (en) 2009-08-07 2015-02-24 Massachusettes Institute Of Technology Method and apparatus for forming MEMS device
JO3382B1 (en) 2008-12-23 2019-03-13 Amgen Inc Human cgrp receptor binding antibodies
TW201104253A (en) 2008-12-31 2011-02-01 Nat Health Research Institutes Microarray chip and method of fabricating for the same
US9409969B2 (en) 2009-02-09 2016-08-09 Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) Repertoire of allo-restricted peptide-specific T cell receptor sequences and use thereof
US8569046B2 (en) 2009-02-20 2013-10-29 Massachusetts Institute Of Technology Microarray with microchannels
DK2398915T3 (en) 2009-02-20 2016-12-12 Synthetic Genomics Inc Synthesis of nucleic acids sequence verified
BRPI1008971A2 (en) 2009-03-09 2016-03-15 Bioatla Llc methods for preparing a conditionally active biological protein, and a conditionally active biological response modifier, conditionally active biological protein, and pharmaceutical composition
US8709717B2 (en) 2009-04-03 2014-04-29 Illumina, Inc. Generation of uniform fragments of nucleic acids using patterned substrates
US7862716B2 (en) 2009-04-13 2011-01-04 Sielc Technologies Corporation HPLC schematic with integrated sample cleaning system
EP2424669B1 (en) 2009-04-29 2020-06-03 Sicpa Holding Sa Method for depositing a biological fluid onto a substrate
WO2010127186A1 (en) 2009-04-30 2010-11-04 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
EP2248914A1 (en) 2009-05-05 2010-11-10 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. The use of class IIB restriction endonucleases in 2nd generation sequencing applications
US9309557B2 (en) 2010-12-17 2016-04-12 Life Technologies Corporation Nucleic acid amplification
US20120156728A1 (en) 2010-12-17 2012-06-21 Life Technologies Corporation Clonal amplification of nucleic acid on solid surface with template walking
US20100292102A1 (en) 2009-05-14 2010-11-18 Ali Nouri System and Method For Preventing Synthesis of Dangerous Biological Sequences
US20100300882A1 (en) 2009-05-26 2010-12-02 General Electric Company Devices and methods for in-line sample preparation of materials
WO2010141249A2 (en) 2009-06-02 2010-12-09 Merck Sharp & Dohme Corp. Generation, characterization and uses thereof of anti-notch3 antibodies
EP2438195B1 (en) 2009-06-02 2014-12-17 The Regents of The University of California Virus discovery by sequencing and assembly of virus-derived sirnas, mirnas, pirnas
US8309710B2 (en) 2009-06-29 2012-11-13 Agilent Technologies, Inc. Use of N-alkyl imidazole for sulfurization of oligonucleotides with an acetyl disulfide
US8642755B2 (en) 2009-06-30 2014-02-04 Agilent Technologies, Inc. Use of thioacetic acid derivatives in the sulfurization of oligonucleotides with phenylacetyl disulfide
GB0912909D0 (en) 2009-07-23 2009-08-26 Olink Genomics Ab Probes for specific analysis of nucleic acids
US8329208B2 (en) 2009-07-28 2012-12-11 Methylation Sciences International Srl Pharmacokinetics of S-adenosylmethionine formulations
WO2011012280A1 (en) 2009-07-30 2011-02-03 Roche Diagnostics Gmbh A set of oligonucleotide probes as well as methods and uses related thereto
MX2012001741A (en) 2009-08-19 2012-03-21 Merck Patent Gmbh Antibodies for the detection of integrin complexes in ffpe material.
US8298767B2 (en) 2009-08-20 2012-10-30 Population Genetics Technologies Ltd Compositions and methods for intramolecular nucleic acid rearrangement
US8476598B1 (en) 2009-08-31 2013-07-02 Sionyx, Inc. Electromagnetic radiation imaging devices and associated methods
US20110082055A1 (en) 2009-09-18 2011-04-07 Codexis, Inc. Reduced codon mutagenesis
US20120184724A1 (en) 2009-09-22 2012-07-19 Agilent Technologies, Inc. Protected monomers and methods of deprotection for rna synthesis
WO2011038241A1 (en) 2009-09-25 2011-03-31 President And Fellows Of Harvard College Nucleic acid amplification and sequencing by synthesis with fluorogenic nucleotides
US8975019B2 (en) 2009-10-19 2015-03-10 University Of Massachusetts Deducing exon connectivity by RNA-templated DNA ligation/sequencing
EP2494062B1 (en) 2009-10-28 2016-12-28 Janssen Biotech, Inc. Anti-glp-1r antibodies and their uses
US20120315670A1 (en) 2009-11-02 2012-12-13 Gen9, Inc. Compositions and Methods for the Regulation of Multiple Genes of Interest in a Cell
US10207240B2 (en) 2009-11-03 2019-02-19 Gen9, Inc. Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly
US20110114549A1 (en) 2009-11-13 2011-05-19 Agilent Technolgies, Inc. Microfluidic device comprising separation columns
WO2011066185A1 (en) 2009-11-25 2011-06-03 Gen9, Inc. Microfluidic devices and methods for gene synthesis
WO2011066186A1 (en) 2009-11-25 2011-06-03 Gen9, Inc. Methods and apparatuses for chip-based dna error reduction
JP5541293B2 (en) 2009-12-03 2014-07-09 日本電気株式会社 Packet receiving apparatus, packet communication system, and packet order control method
US8500979B2 (en) 2009-12-31 2013-08-06 Intel Corporation Nanogap chemical and biochemical sensors
US9217144B2 (en) 2010-01-07 2015-12-22 Gen9, Inc. Assembly of high fidelity polynucleotides
US9758817B2 (en) 2010-01-13 2017-09-12 Agilent Technologies, Inc. Method for identifying a nucleic acid in a sample
KR101230350B1 (en) 2010-01-27 2013-02-06 주식회사 엘지화학 Battery Pack of Excellent Structural Stability
KR20110094878A (en) 2010-02-18 2011-08-24 삼성전자주식회사 Composition of forming an oligomer array and methods of forming an oligomer array
GB201003036D0 (en) 2010-02-23 2010-04-07 Fermentas Uab Restriction endonucleases and their applications
US20120027786A1 (en) 2010-02-23 2012-02-02 Massachusetts Institute Of Technology Genetically programmable pathogen sense and destroy
US8716467B2 (en) 2010-03-03 2014-05-06 Gen9, Inc. Methods and devices for nucleic acid synthesis
EP2542676A1 (en) 2010-03-05 2013-01-09 Synthetic Genomics, Inc. Methods for cloning and manipulating genomes
EP2703491B1 (en) 2010-04-09 2017-03-08 The Catholic University Of America Protein and nucleic acid delivery vehicles, components and mechanisms thereof
US10240194B2 (en) 2010-05-13 2019-03-26 Gen9, Inc. Methods for nucleotide sequencing and high fidelity polynucleotide synthesis
US9187777B2 (en) 2010-05-28 2015-11-17 Gen9, Inc. Methods and devices for in situ nucleic acid synthesis
GB2481425A (en) 2010-06-23 2011-12-28 Iti Scotland Ltd Method and device for assembling polynucleic acid sequences
EA201390011A1 (en) 2010-07-28 2013-07-30 Иммьюнокор Лтд. T-CELL RECEPTORS
ES2690753T3 (en) 2010-09-21 2018-11-22 Agilent Technologies, Inc. Increased confidence in allele identifications with molecular count
US8715933B2 (en) 2010-09-27 2014-05-06 Nabsys, Inc. Assay methods using nicking endonucleases
US20130289246A1 (en) 2010-09-30 2013-10-31 Vanderbilt University Influenza virus antibodies and immunogens and uses therefor
WO2012051327A2 (en) 2010-10-12 2012-04-19 Cornell University Method of dual-adapter recombination for efficient concatenation of multiple dna fragments in shuffled or specified arrangements
EP2630264A4 (en) 2010-10-22 2014-04-02 Harvard College Orthogonal amplification and assembly of nucleic acid sequences
AU2011323107B2 (en) 2010-11-05 2015-09-10 Illumina, Inc. Linking sequence reads using paired code tags
US10457935B2 (en) 2010-11-12 2019-10-29 Gen9, Inc. Protein arrays and methods of using and making the same
JP6118725B2 (en) 2010-11-12 2017-04-19 ジェン９・インコーポレイテッドＧｅｎ９，ＩＮＣ． Methods and devices for nucleic acid synthesis
WO2012092260A1 (en) 2010-12-27 2012-07-05 Ibis Biosciences, Inc. Compositions and methods for producing single-stranded circular dna
US20120164633A1 (en) 2010-12-27 2012-06-28 Ibis Biosciences, Inc. Digital droplet sequencing
CN103620032B (en) 2010-12-31 2016-02-24 生物蛋白有限公司 The quick humanization of antibody
EP2692853A4 (en) 2011-03-30 2014-12-03 Nat Ct Geriatrics & Gerontology Membrane-separation-type culture device, membrane-separation-type culture kit, stem cell separation method using same, and separation membrane
US10131903B2 (en) 2011-04-01 2018-11-20 The Regents Of The University Of California Microfluidic platform for synthetic biology applications
US9384920B1 (en) 2011-04-04 2016-07-05 Eric J. Bakulich Locking knob
US20140357497A1 (en) 2011-04-27 2014-12-04 Kun Zhang Designing padlock probes for targeted genomic sequencing
US8722585B2 (en) 2011-05-08 2014-05-13 Yan Wang Methods of making di-tagged DNA libraries from DNA or RNA using double-tagged oligonucleotides
SG10201605049QA (en) 2011-05-20 2016-07-28 Fluidigm Corp Nucleic acid encoding reactions
US9752176B2 (en) 2011-06-15 2017-09-05 Ginkgo Bioworks, Inc. Methods for preparative in vitro cloning
US9487824B2 (en) 2011-06-28 2016-11-08 Igor Kutyavin Methods and compositions for enrichment of nucleic acids in mixtures of highly homologous sequences
US20130045483A1 (en) 2011-07-01 2013-02-21 Whitehead Institute For Biomedical Research Yeast cells expressing amyloid beta and uses therefor
WO2013019361A1 (en) 2011-07-07 2013-02-07 Life Technologies Corporation Sequencing methods
US20130017978A1 (en) 2011-07-11 2013-01-17 Finnzymes Oy Methods and transposon nucleic acids for generating a dna library
WO2013010062A2 (en) 2011-07-14 2013-01-17 Life Technologies Corporation Nucleic acid complexity reduction
WO2013023220A2 (en) * 2011-08-11 2013-02-14 Life Technologies Corporation Systems and methods for nucleic acid-based identification
US20150203839A1 (en) 2011-08-26 2015-07-23 Gen9, Inc. Compositions and Methods for High Fidelity Assembly of Nucleic Acids
JP2014526899A (en) 2011-08-26 2014-10-09 ジェン９・インコーポレイテッド Compositions and methods for high fidelity assembly of nucleic acids
ES2844529T3 (en) 2011-09-01 2021-07-22 Genome Compiler Corp System for the design, visualization and transactions of polynucleotide constructions to manufacture them
EP2753714B1 (en) 2011-09-06 2017-04-12 Gen-Probe Incorporated Circularized templates for sequencing
US8840981B2 (en) 2011-09-09 2014-09-23 Eastman Kodak Company Microfluidic device with multilayer coating
NO2723764T3 (en) 2011-09-15 2018-05-26
US20130109596A1 (en) 2011-09-26 2013-05-02 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
WO2013055822A2 (en) 2011-10-11 2013-04-18 Life Technologies Corporation Systems and methods for analysis and interpretation of nucleic acid sequence data
SG10201510189WA (en) 2011-10-19 2016-01-28 Nugen Technologies Inc Compositions And Methods For Directional Nucleic Acid Amplification And Sequencing
US8987174B2 (en) 2011-10-28 2015-03-24 Prognosys Biosciences, Inc. Methods for manufacturing molecular arrays
US8815782B2 (en) 2011-11-11 2014-08-26 Agilent Technologies, Inc. Use of DNAzymes for analysis of an RNA sample
US8450107B1 (en) 2011-11-30 2013-05-28 The Broad Institute Inc. Nucleotide-specific recognition sequences for designer TAL effectors
US20130137173A1 (en) 2011-11-30 2013-05-30 Feng Zhang Nucleotide-specific recognition sequences for designer tal effectors
JP2013151468A (en) 2011-11-30 2013-08-08 Agilent Technologies Inc Novel methods for synthesis and purification of oligomers
US9279154B2 (en) 2011-12-21 2016-03-08 Illumina, Inc. Apparatus and methods for kinetic analysis and determination of nucleic acid sequences
WO2013093693A1 (en) 2011-12-22 2013-06-27 Rinat Neuroscience Corp. Staphylococcus aureus specific antibodies and uses thereof
US9593375B2 (en) 2011-12-30 2017-03-14 Quest Diagnostics Investments Incorporated Nucleic acid analysis using emulsion PCR
CN104220602B (en) 2012-02-01 2018-10-30 合成基因组股份有限公司 The material and method of nucleic acid molecules are minimized for resultant fault
EP2820174B1 (en) 2012-02-27 2019-12-25 The University of North Carolina at Chapel Hill Methods and uses for molecular tags
US9670529B2 (en) 2012-02-28 2017-06-06 Population Genetics Technologies Ltd. Method for attaching a counter sequence to a nucleic acid sample
CA2867235C (en) 2012-03-14 2021-11-09 Innovative Targeting Solutions Inc. Generating targeted sequence diversity in fusion proteins
US9150853B2 (en) 2012-03-21 2015-10-06 Gen9, Inc. Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
WO2013149078A1 (en) 2012-03-28 2013-10-03 Kci Licensing, Inc. Reduced-pressure systems, dressings, and methods facilitating separation of electronic and clinical component parts
US9732384B2 (en) 2012-04-02 2017-08-15 Lux Bio Group, Inc. Apparatus and method for molecular separation, purification, and sensing
WO2013154770A1 (en) 2012-04-10 2013-10-17 The Trustees Of Princeton University Ultra-sensitive sensor
US20150353921A9 (en) 2012-04-16 2015-12-10 Jingdong Tian Method of on-chip nucleic acid molecule synthesis
US20130281308A1 (en) 2012-04-24 2013-10-24 Gen9, Inc. Methods for sorting nucleic acids and preparative in vitro cloning
EP4001427A1 (en) 2012-04-24 2022-05-25 Gen9, Inc. Methods for sorting nucleic acids and multiplexed preparative in vitro cloning
MX2019001355A (en) 2012-05-10 2023-01-17 Bioatla Llc Multi-specific monoclonal antibodies.
EP2852687A4 (en) 2012-05-21 2016-10-05 Scripps Research Inst Methods of sample preparation
DK2856375T3 (en) 2012-06-01 2018-11-05 European Molecular Biology Laboratory High capacity storage of digital information in DNA
US10308979B2 (en) 2012-06-01 2019-06-04 Agilent Technologies, Inc. Target enrichment and labeling for multi-kilobase DNA
US9102936B2 (en) 2012-06-11 2015-08-11 Agilent Technologies, Inc. Method of adaptor-dimer subtraction using a CRISPR CAS6 protein
AU2013280661A1 (en) 2012-06-25 2015-01-22 Gen9, Inc. Methods for nucleic acid assembly and high throughput sequencing
SG10201610861XA (en) 2012-07-03 2017-02-27 Integrated Dna Tech Inc Tm-enhanced blocking oligonucleotides and baits for improved target enrichment and reduced off-target selection
US9255245B2 (en) 2012-07-03 2016-02-09 Agilent Technologies, Inc. Sample probes and methods for sampling intracellular material
WO2014011800A1 (en) 2012-07-10 2014-01-16 Pivot Bio, Inc. Methods for multipart, modular and scarless assembly of dna molecules
US9073962B2 (en) 2012-07-12 2015-07-07 Massachusetts Institute Of Technology Methods of serial assembly of DNA bricks into larger structures
JP6239813B2 (en) 2012-07-18 2017-11-29 株式会社Ｓｃｒｅｅｎセミコンダクターソリューションズ Substrate processing apparatus and substrate processing method
CN108875312A (en) * 2012-07-19 2018-11-23 哈佛大学校长及研究员协会 Utilize the method for nucleic acid storage information
CN104684926B (en) 2012-07-27 2022-04-08 伊利诺伊州大学理事会 Engineered T cell receptors
WO2014021938A1 (en) 2012-08-02 2014-02-06 The Board Of Trustees Of The Leland Stanford Junior University Methods and apparatus for nucleic acid synthesis using oligo-templated polymerization
IL288256B2 (en) 2012-08-16 2023-10-01 Synthetic Genomics Inc Digital to biological converter
EP2890836B1 (en) 2012-08-31 2019-07-17 The Scripps Research Institute Methods related to modulators of eukaryotic cells
US9328376B2 (en) 2012-09-05 2016-05-03 Bio-Rad Laboratories, Inc. Systems and methods for stabilizing droplets
CN107541546B (en) 2012-10-15 2021-06-15 生命技术公司 Compositions, methods, systems, and kits for target nucleic acid enrichment
KR20140048733A (en) 2012-10-16 2014-04-24 삼성전자주식회사 Multiwell plate and method for analyzing target material using the same
US9410173B2 (en) 2012-10-24 2016-08-09 Clontech Laboratories, Inc. Template switch-based methods for producing a product nucleic acid
EP3569226A1 (en) 2012-12-04 2019-11-20 Phosphorex, Inc. Microparticles and nanoparticles having negative surface charges
CN104837994A (en) 2012-12-06 2015-08-12 安捷伦科技有限公司 Molecular fabrication
EP2929048B1 (en) 2012-12-06 2017-12-13 Agilent Technologies, Inc. Restriction enzyme-free target enrichment
SG10201704633UA (en) 2012-12-10 2017-07-28 Resolution Bioscience Inc Methods for targeted genomic analysis
US9976162B2 (en) 2012-12-10 2018-05-22 Agilent Technologies, Inc. Pairing code directed assembly
WO2014093694A1 (en) 2012-12-12 2014-06-19 The Broad Institute, Inc. Crispr-cas nickase systems, methods and compositions for sequence manipulation in eukaryotes
WO2014133457A1 (en) 2013-02-28 2014-09-04 Nanyang Technological University Method of manufacturing a device for supporting biological material growth and device therefrom
EP2964778B1 (en) 2013-03-05 2019-10-09 Agilent Technologies, Inc. Detection of genomic rearrangements by sequence capture
US9580746B2 (en) 2013-03-05 2017-02-28 Agilent Technologies, Inc. Synthesis of long fish probes
US10280417B2 (en) 2013-03-13 2019-05-07 Gen 9, Inc. Compositions, methods and apparatus for oligonucleotides synthesis
US10053719B2 (en) 2013-03-13 2018-08-21 Gen9, Inc. Compositions and methods for synthesis of high fidelity oligonucleotides
CA2906556C (en) 2013-03-15 2022-07-05 Gen9, Inc. Compositions and methods for multiplex nucleic acids synthesis
US20140274729A1 (en) 2013-03-15 2014-09-18 Nugen Technologies, Inc. Methods, compositions and kits for generation of stranded rna or dna libraries
AR095517A1 (en) 2013-03-15 2015-10-21 Genentech Inc ANTIBODIES AGAINST THE CHEMIOATRAYENT RECEIVER EXPRESSED IN T HELPER 2 CELLS (ANTI-CRTh2) AND METHODS OF USE
US20140274741A1 (en) 2013-03-15 2014-09-18 The Translational Genomics Research Institute Methods to capture and sequence large fragments of dna and diagnostic methods for neuromuscular disease
ES2946689T3 (en) 2013-03-15 2023-07-24 Univ Leland Stanford Junior Identification and use of circulating nucleic acid tumor markers
US9771613B2 (en) 2013-04-02 2017-09-26 Molecular Assemblies, Inc. Methods and apparatus for synthesizing nucleic acid
US10683536B2 (en) 2013-04-02 2020-06-16 Molecular Assemblies, Inc. Reusable initiators for synthesizing nucleic acids
US9279149B2 (en) 2013-04-02 2016-03-08 Molecular Assemblies, Inc. Methods and apparatus for synthesizing nucleic acids
US20150293102A1 (en) 2013-04-13 2015-10-15 Jung-Uk Shim Detecting low-abundant analyte in microfluidic droplets
ITRM20130278A1 (en) 2013-05-10 2014-11-11 Consiglio Nazionale Ricerche PROCESS OF MANUFACTURE OF SELF-ASSEMBLED FILMS OF BLOCKED COPOLYMERS
NZ715815A (en) 2013-06-26 2017-02-24 Guangzhou Xiangxue Pharmaceutical Co Ltd High-stability t-cell receptor and preparation method and application thereof
US20150010953A1 (en) 2013-07-03 2015-01-08 Agilent Technologies, Inc. Method for producing a population of oligonucleotides that has reduced synthesis errors
KR20150005062A (en) 2013-07-04 2015-01-14 삼성전자주식회사 Processor using mini-cores
US10421957B2 (en) 2013-07-29 2019-09-24 Agilent Technologies, Inc. DNA assembly using an RNA-programmable nickase
LT3027771T (en) 2013-07-30 2019-04-25 Gen9, Inc. Methods for the production of long length clonal sequence verified nucleic acid constructs
TWI695067B (en) 2013-08-05 2020-06-01 美商扭轉生物科技有限公司 De novo synthesized gene libraries
US20150044648A1 (en) 2013-08-07 2015-02-12 Nike, Inc. Activity recognition with activity reminders
CN104371019B (en) 2013-08-13 2019-09-10 鸿运华宁（杭州）生物医药有限公司 It is a kind of can with GLP-1R specifically bind antibody and its with the fused protein of GLP-1
GB201314721D0 (en) 2013-08-16 2013-10-02 Almagen Ltd A method of selectively masking one or more sites on a surface and a method of synthesising an array of molecules
EP3965111A1 (en) 2013-08-30 2022-03-09 Personalis, Inc. Methods and systems for genomic analysis
EP3044228B1 (en) 2013-09-14 2021-04-07 Chemgenes Corporation Highly efficient synthesis of long rna using reverse direction approach
WO2015040075A1 (en) 2013-09-18 2015-03-26 Genome Research Limited Genomic screening methods using rna-guided endonucleases
US9422325B2 (en) 2013-10-04 2016-08-23 Trustees Of Tufts College Glycosylation reactions using phenyl(trifluoroethyl)iodonium salts
CN105745528A (en) 2013-10-07 2016-07-06 赛卢拉研究公司 Methods and systems for digitally counting features on arrays
EP3063301A4 (en) 2013-10-29 2017-07-19 Longhorn Vaccines and Diagnostics, LLC Next generation genomic sequencing methods
BR112016012164A2 (en) 2013-11-26 2017-09-26 Xenco Medical LLC implant release system
CN110219055A (en) 2013-11-27 2019-09-10 Gen9股份有限公司 Nucleic acid library and its manufacturing method
TW202043467A (en) 2013-12-04 2020-12-01 日商中外製藥股份有限公司 Antigen-binding molecules, the antigen-binding activity of which varies according to the concentration of compounds, and libraries of said molecules
US20160297883A1 (en) 2013-12-04 2016-10-13 Innovative Targeting Solutions, Inc. G-protein coupled receptor agonists and methods
CA2945628A1 (en) 2013-12-09 2015-06-18 Integrated Dna Technologies, Inc. Long nuceic acid sequences containing variable regions
KR102630750B1 (en) 2013-12-17 2024-01-30 제넨테크, 인크. Methods of treating cancers using pd-1 axis binding antagonists and taxanes
GB2521387B (en) 2013-12-18 2020-05-27 Ge Healthcare Uk Ltd Oligonucleotide data storage on solid supports
US10537889B2 (en) 2013-12-31 2020-01-21 Illumina, Inc. Addressable flow cell using patterned electrodes
US9587268B2 (en) 2014-01-29 2017-03-07 Agilent Technologies Inc. Fast hybridization for next generation sequencing target enrichment
WO2015120403A1 (en) 2014-02-08 2015-08-13 The Regents Of The University Of Colorado, A Body Corporate Multiplexed linking pcr
US10208338B2 (en) 2014-03-03 2019-02-19 Swift Biosciences, Inc. Enhanced adaptor ligation
EP3590958A1 (en) 2014-03-14 2020-01-08 Immunocore Limited Tcr libraries
US10675618B2 (en) 2014-03-27 2020-06-09 University Of Maryland, College Park Integration of ex situ fabricated porous polymer monoliths into fluidic chips
US10190161B2 (en) 2014-04-03 2019-01-29 Stmicroelectronics S.R.L. Apparatus and method for nucleic acid sequencing based on nanowire detectors
WO2015160004A1 (en) 2014-04-15 2015-10-22 볼보 컨스트럭션 이큅먼트 에이비 Device for controlling engine and hydraulic pump of construction equipment and control method therefor
GB201407852D0 (en) 2014-05-02 2014-06-18 Iontas Ltd Preparation of libraries od protein variants expressed in eukaryotic cells and use for selecting binding molecules
SG10201809312QA (en) 2014-05-16 2018-11-29 Illumina Inc Nucleic acid synthesis techniques
US20150361423A1 (en) 2014-06-16 2015-12-17 Agilent Technologies, Inc. High throughput gene assembly in droplets
US20150361422A1 (en) 2014-06-16 2015-12-17 Agilent Technologies, Inc. High throughput gene assembly in droplets
US10870845B2 (en) 2014-07-01 2020-12-22 Global Life Sciences Solutions Operations UK Ltd Methods for capturing nucleic acids
US10472620B2 (en) 2014-07-01 2019-11-12 General Electric Company Method, substrate and device for separating nucleic acids
US20170198268A1 (en) 2014-07-09 2017-07-13 Gen9, Inc. Compositions and Methods for Site-Directed DNA Nicking and Cleaving
EP3169776A4 (en) 2014-07-14 2018-07-04 The Regents of The University of California Crispr/cas transcriptional modulation
EP3169781B1 (en) 2014-07-15 2020-04-08 Life Technologies Corporation Compositions and methods for nucleic acid assembly
WO2016022557A1 (en) 2014-08-05 2016-02-11 Twist Bioscience Corporation Cell free cloning of nucleic acids
EP3913066A1 (en) 2014-09-09 2021-11-24 Igenomx International Genomics Corporation Compositions for rapid nucleic acid library preparation
WO2016053881A1 (en) 2014-10-03 2016-04-07 Life Technologies Corporation Genetic sequence verification compositions, methods and kits
CN107002078A (en) 2014-10-09 2017-08-01 生命技术公司 CRISPR oligonucleotides and gene editing
US10648103B2 (en) 2014-10-10 2020-05-12 Invitae Corporation Universal blocking oligo system and improved hybridization capture methods for multiplexed capture reactions
SG11201703138RA (en) 2014-10-18 2017-05-30 Girik Malik A biomolecule based data storage system
CA3001986C (en) 2014-10-22 2023-02-21 The Regents Of The University Of California High definition microdroplet printer
US9890417B2 (en) 2014-11-03 2018-02-13 Agilent Technologies, Inc. Signal amplification of fluorescence in situ hybridization
US10233490B2 (en) 2014-11-21 2019-03-19 Metabiotech Corporation Methods for assembling and reading nucleic acid sequences from mixed populations
CN104562213A (en) 2014-12-26 2015-04-29 北京诺禾致源生物信息科技有限公司 Amplification sublibrary and construction method thereof
US10669304B2 (en) 2015-02-04 2020-06-02 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
CA2975855A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Compositions and methods for synthetic gene assembly
US9834774B2 (en) 2015-02-11 2017-12-05 Agilent Technologies, Inc. Methods and compositions for rapid seamless DNA assembly
EP3256624A4 (en) 2015-02-13 2018-07-25 Vaccine Research Institute of San Diego Materials and methods to analyze rna isoforms in transcriptomes
CN104734848A (en) * 2015-03-02 2015-06-24 郑州轻工业学院 Recombinant DNA technology based information encrypting and hiding method and application
EA201792084A8 (en) 2015-04-01 2019-06-28 Зе Скриппс Рисёрч Инститьют METHODS AND COMPOSITIONS RELATED TO POLYPEPTIDES - GPCR AGONISTS
US10730911B2 (en) 2015-04-08 2020-08-04 Universitat Zurich Backbone-cyclized peptidomimetics with GLP-1R modulating activity
US11164661B2 (en) 2015-04-10 2021-11-02 University Of Washington Integrated system for nucleic acid-based storage and retrieval of digital data using keys
US10125198B2 (en) 2015-04-17 2018-11-13 Distributed Bio, Inc. Method for mass humanization of non-human antibodies
US9981239B2 (en) 2015-04-21 2018-05-29 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
WO2016173719A1 (en) 2015-04-30 2016-11-03 Abcheck S.R.O. Method for mass humanization of rabbit antibodies
WO2016183100A1 (en) 2015-05-11 2016-11-17 Twist Bioscience Corporation Compositions and methods for nucleic acid amplification
EP3322812B1 (en) 2015-07-13 2022-05-18 President and Fellows of Harvard College Methods for retrievable information storage using nucleic acids
CN105119717A (en) * 2015-07-21 2015-12-02 郑州轻工业学院 DNA coding based encryption system and encryption method
KR20180050411A (en) 2015-09-18 2018-05-14 트위스트 바이오사이언스 코포레이션 Oligonucleotide mutant library and its synthesis
CN108698012A (en) 2015-09-22 2018-10-23 特韦斯特生物科学公司 Flexible substrates for nucleic acid synthesis
US20180320166A1 (en) 2015-10-01 2018-11-08 University Of Washington Multiplex pairwise assembly of dna oligonucleotides
US20170141793A1 (en) 2015-11-13 2017-05-18 Microsoft Technology Licensing, Llc Error correction for nucleotide data stores
EP3384077A4 (en) 2015-12-01 2019-05-08 Twist Bioscience Corporation Functionalized surfaces and preparation thereof
EP4043584A1 (en) 2015-12-08 2022-08-17 Twinstrand Biosciences, Inc. Improved adapters, methods, and compositions for duplex sequencing
EP3277810B8 (en) 2016-01-08 2020-07-15 Maxion Therapeutics Limited Binding members with altered diversity scaffold domains
GB201604492D0 (en) 2016-03-16 2016-04-27 Immatics Biotechnologies Gmbh Transfected t-cells and t-cell receptors for use in immunotherapy against cancers
CN105838711A (en) * 2016-05-09 2016-08-10 张阳 Single-stranded deoxyribonucleic acid for information storage and encryption
WO2017214574A1 (en) 2016-06-10 2017-12-14 Twist Bioscience Corporation Systems and methods for automated annotation and screening of biological sequences
US11708574B2 (en) 2016-06-10 2023-07-25 Myriad Women's Health, Inc. Nucleic acid sequencing adapters and uses thereof
WO2018026920A1 (en) 2016-08-03 2018-02-08 Twist Bioscience Corporation Textured surfaces for polynucleotide synthesis
AU2017315294B2 (en) 2016-08-22 2023-12-21 Twist Bioscience Corporation De novo synthesized nucleic acid libraries
WO2018045325A1 (en) 2016-09-02 2018-03-08 Lentigen Technology, Inc. Compositions and methods for treating cancer with duocars
US10417457B2 (en) 2016-09-21 2019-09-17 Twist Bioscience Corporation Nucleic acid based data storage
EP3541973B1 (en) 2016-11-18 2024-03-27 Twist Bioscience Corporation Polynucleotide libraries having controlled stoichiometry and synthesis thereof
CN110366613A (en) 2016-12-16 2019-10-22 特韦斯特生物科学公司 The Mutant libraries of immunological synapse and its synthesis
JP7155126B2 (en) 2016-12-21 2022-10-18 セファロン インコーポレイテッド Antibody that specifically binds to human IL-15 and use thereof
US11550939B2 (en) 2017-02-22 2023-01-10 Twist Bioscience Corporation Nucleic acid based data storage using enzymatic bioencryption
KR102607157B1 (en) 2017-03-15 2023-11-27 트위스트 바이오사이언스 코포레이션 De novo synthesized combinatorial nucleic acid libraries
CN110913865A (en) 2017-03-15 2020-03-24 特韦斯特生物科学公司 Library of variants of immune synapses and synthesis thereof
HRP20230936T1 (en) 2017-03-23 2023-11-24 QBiotics Pty Ltd Combination therapy for the treatment or prevention of tumours
US11274344B2 (en) 2017-03-30 2022-03-15 Grail, Inc. Enhanced ligation in sequencing library preparation
ES2929837T3 (en) 2017-04-23 2022-12-02 Illumina Cambridge Ltd Compositions and methods to improve sample identification in indexed nucleic acid libraries
SG11201910070PA (en) 2017-05-08 2019-11-28 Illumina Inc Universal short adapters for indexing of polynucleotide samples
WO2018231864A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
KR102628876B1 (en) 2017-06-12 2024-01-23 트위스트 바이오사이언스 코포레이션 Methods for seamless nucleic acid assembly
JP7015388B2 (en) 2017-07-18 2022-02-02 インベスティガシオネス・フォレスタレス・ビオフォレスト・エス・アー Methods and Devices for Asymmetric Polar Inversion in Electrical Membrane Processes
CN111566125A (en) 2017-09-11 2020-08-21 特韦斯特生物科学公司 GPCR binding proteins and synthesis thereof
CA3079613A1 (en) 2017-10-20 2019-04-25 Twist Bioscience Corporation Heated nanowells for polynucleotide synthesis
EP3701023A4 (en) 2017-10-27 2021-07-28 Twist Bioscience Corporation Systems and methods for polynucleotide scoring
US11427867B2 (en) 2017-11-29 2022-08-30 Xgenomes Corp. Sequencing by emergence
CA3088911A1 (en) 2018-01-04 2019-07-11 Twist Bioscience Corporation Dna-based digital information storage
US10722916B2 (en) 2018-01-19 2020-07-28 Caulk Garbage Can LLC Caulk gun attachment for wiping excess caulk
AU2019270243A1 (en) 2018-05-18 2021-01-07 Twist Bioscience Corporation Polynucleotides, reagents, and methods for nucleic acid hybridization
EP3814494B1 (en) 2018-06-29 2023-11-01 Thermo Fisher Scientific GENEART GmbH High throughput assembly of nucleic acid molecules
US10963953B2 (en) 2018-10-10 2021-03-30 Alliance Inspection Management, LLC Reserve management for continuous bidding portal
US20200222875A1 (en) 2018-12-26 2020-07-16 Twist Bioscience Corporation Highly accurate de novo polynucleotide synthesis
EP3938505A4 (en) 2019-02-25 2022-11-30 Twist Bioscience Corporation Compositions and methods for next generation sequencing
KR20210143766A (en) 2019-02-26 2021-11-29 트위스트 바이오사이언스 코포레이션 Variant Nucleic Acid Libraries for the GLP1 Receptor
KR20210144698A (en) 2019-02-26 2021-11-30 트위스트 바이오사이언스 코포레이션 Variant Nucleic Acid Libraries for Antibody Optimization
US11332738B2 (en) 2019-06-21 2022-05-17 Twist Bioscience Corporation Barcode-based nucleic acid sequence assembly
US20220243195A1 (en) 2019-06-21 2022-08-04 Twist Bioscience Corporation Barcode-based nucleic acid sequence assembly
EP4004232A4 (en) 2019-07-22 2023-08-09 Igenomx International Genomics Corporation Methods and compositions for high throughput sample preparation using double unique dual indexing
US20220411780A1 (en) 2019-09-13 2022-12-29 University Health Network Detection of circulating tumor dna using double stranded hybrid capture
KR20220069046A (en) 2019-09-23 2022-05-26 트위스트 바이오사이언스 코포레이션 Variant Nucleic Acid Libraries for Single Domain Antibodies
KR20220066151A (en) 2019-09-23 2022-05-23 트위스트 바이오사이언스 코포레이션 Variant Nucleic Acid Library for CRTH2
AU2020400030A1 (en) 2019-12-09 2022-07-07 Twist Bioscience Corporation Variant nucleic acid libraries for adenosine receptors
KR20230017781A (en) 2020-04-27 2023-02-06 트위스트 바이오사이언스 코포레이션 Variant nucleic acid library for coronavirus
EP4179001A2 (en) 2020-07-07 2023-05-17 Twist Bioscience Corporation Devices and methods for light-directed polymer synthesis
WO2022046797A1 (en) 2020-08-25 2022-03-03 Twist Bioscience Corporation Compositions and methods for library sequencing
WO2022046944A2 (en) 2020-08-26 2022-03-03 Twist Bioscience Corporation Methods and compositions relating to glp1r variants
CN117043171A (en) 2020-08-28 2023-11-10 特韦斯特生物科学公司 Apparatus and method for synthesis
EP4225912A1 (en) 2020-10-05 2023-08-16 Twist Bioscience Corporation Hybridization methods and reagents
EP4229210A1 (en) 2020-10-19 2023-08-23 Twist Bioscience Corporation Methods of synthesizing oligonucleotides using tethered nucleotides
WO2022087293A1 (en) 2020-10-22 2022-04-28 Twist Bioscience Corporation Methods and systems for detecting coronavirus
US20220135965A1 (en) 2020-10-26 2022-05-05 Twist Bioscience Corporation Libraries for next generation sequencing
WO2022098662A2 (en) 2020-11-03 2022-05-12 Twist Bioscience Corporation Methods and compositions relating to chemokine receptor variants
US20220259319A1 (en) 2021-01-21 2022-08-18 Twist Bioscience Corporation Methods and compositions relating to adenosine receptors
WO2022178137A1 (en) 2021-02-19 2022-08-25 Twist Bioscience Corporation Libraries for identification of genomic variants
US20220307010A1 (en) 2021-03-24 2022-09-29 Twist Bioscience Corporation Variant nucleic acid libraries for tigit

Also Published As

Publication number Publication date
KR20190119107A (en) 2019-10-21
EP3586255A1 (en) 2020-01-01
US20230153452A1 (en) 2023-05-18
JP2020508661A (en) 2020-03-26
CN110892485B (en) 2024-03-22
WO2018156792A1 (en) 2018-08-30
EP3586255A4 (en) 2021-03-31
US20180253563A1 (en) 2018-09-06
CA3054303A1 (en) 2018-08-30
CN110892485A (en) 2020-03-17
US11550939B2 (en) 2023-01-10

Similar Documents

Publication Publication Date Title
SG11201907713WA (en) Nucleic acid based data storage
SG11201906695VA (en) Universal bchain e3a connections (ubec)
SG11201908489XA (en) De novo synthesized combinatorial nucleic acid libraries
SG11201909724RA (en) Systems and processes for conversion of crude oil
SG11201909011PA (en) Niraparib compositions
SG11201901531TA (en) Regulation of gene expression using engineered nucleases
SG11201906213UA (en) Modulating expression of polypeptides via new gene switch expression systems
SG11201806117TA (en) Computer security based on artificial intelligence
SG11201910101SA (en) Alphavirus neoantigen vectors
SG11201806781SA (en) Registry and automated management method for blockchain-enforced smart contracts
SG11201900550QA (en) Method and system for private communication
SG11201909432SA (en) Compounds for increasing genome editing efficiency
SG11201907531XA (en) Constraining motion vector information derived by decoder-side motion vector derivation
SG11201807608VA (en) Dynamically convey information of demodulation reference signal and phase noise compensation reference signal
SG11201804022SA (en) Systems and methods for digital identity management and permission controls within distributed network nodes
SG11201901180WA (en) Systems and methods for providing identity assurance for decentralized applications
SG11201804771WA (en) Systems and methods for providing financial data to financial instruments in a distributed ledger system
SG11201901563UA (en) De novo synthesized nucleic acid libraries
SG11201906192SA (en) Methods of treating cancer with anti-pd-1 antibodies
SG11201900634VA (en) Chimeric antigen receptor
SG11201901211XA (en) Apparatuses and methods including ferroelectric memory and for accessing ferroelectric memory
SG11201805648PA (en) Crypto multiple security asset creation and redemption platform
SG11201908056QA (en) Anti-par2 antibodies and uses thereof
SG11201811742YA (en) Systems and methods for information processing
SG11201900992XA (en) Computer architecture and method for recommending asset repairs