CA2955154C - Treatment of cancer using a cd33 chimeric antigen receptor - Google Patents

Treatment of cancer using a cd33 chimeric antigen receptor Download PDF

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Publication number
CA2955154C
CA2955154C CA2955154A CA2955154A CA2955154C CA 2955154 C CA2955154 C CA 2955154C CA 2955154 A CA2955154 A CA 2955154A CA 2955154 A CA2955154 A CA 2955154A CA 2955154 C CA2955154 C CA 2955154C
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Canada
Prior art keywords
seq
amino acid
acid sequence
cdr2
cdr1
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CA2955154A
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English (en)
French (fr)
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CA2955154A1 (en
Inventor
Jennifer BROGDON
Hilmar Ebersbach
Saar GILL
David Glass
Thomas Huber
Julia JASCUR
Saad KENDERIAN
Joan Mannick
Michael C. Milone
Leon Murphy
Celeste RICHARDSON
Reshma Singh
Huijuan SONG
Qilong WU
Jiquan Zhang
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Novartis AG
University of Pennsylvania Penn
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Novartis AG
University of Pennsylvania Penn
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Publication of CA2955154A1 publication Critical patent/CA2955154A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CA2955154A 2014-07-21 2015-07-21 Treatment of cancer using a cd33 chimeric antigen receptor Active CA2955154C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2014082589 2014-07-21
CNPCT/CN2014/082589 2014-07-21
CNPCT/CN2014/090504 2014-11-06
CN2014090504 2014-11-06
PCT/US2015/041390 WO2016014576A1 (en) 2014-07-21 2015-07-21 Treatment of cancer using a cd33 chimeric antigen receptor

Publications (2)

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CA2955154A1 CA2955154A1 (en) 2016-01-28
CA2955154C true CA2955154C (en) 2023-10-31

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CA2955154A Active CA2955154C (en) 2014-07-21 2015-07-21 Treatment of cancer using a cd33 chimeric antigen receptor

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US (4) US9777061B2 (show.php)
EP (2) EP3172234B1 (show.php)
JP (2) JP6831777B2 (show.php)
KR (1) KR102594343B1 (show.php)
CN (2) CN107109419B (show.php)
AU (2) AU2015292755B2 (show.php)
BR (1) BR112017001242A2 (show.php)
CA (1) CA2955154C (show.php)
CO (1) CO2017000510A2 (show.php)
ES (1) ES2805475T3 (show.php)
IL (1) IL250138B (show.php)
MX (1) MX390943B (show.php)
RU (1) RU2747384C2 (show.php)
SG (2) SG11201700416TA (show.php)
TW (1) TWI719942B (show.php)
WO (1) WO2016014576A1 (show.php)
ZA (1) ZA201700157B (show.php)

Families Citing this family (204)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2817331B1 (en) 2012-02-22 2023-08-30 The Trustees of the University of Pennsylvania Use of the cd2 signaling domain in second-generation chimeric antigen receptors
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