CA2744921C - Hybrid expression of neisserial proteins - Google Patents

Hybrid expression of neisserial proteins Download PDF

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Publication number
CA2744921C
CA2744921C CA2744921A CA2744921A CA2744921C CA 2744921 C CA2744921 C CA 2744921C CA 2744921 A CA2744921 A CA 2744921A CA 2744921 A CA2744921 A CA 2744921A CA 2744921 C CA2744921 C CA 2744921C
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CA
Canada
Prior art keywords
protein
proteins
hybrid
buffer
strain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2744921A
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English (en)
French (fr)
Other versions
CA2744921A1 (en
Inventor
Maria Beatrice Arico
Maurizio Comanducci
Cesira Galeotti
Vega Masignani
Marzia Monica Giuliani
Mariagrazia Pizza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GSK Vaccines SRL
Original Assignee
Chiron SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26243750&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2744921(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0004695A external-priority patent/GB0004695D0/en
Priority claimed from GB0027675A external-priority patent/GB0027675D0/en
Application filed by Chiron SRL filed Critical Chiron SRL
Publication of CA2744921A1 publication Critical patent/CA2744921A1/en
Application granted granted Critical
Publication of CA2744921C publication Critical patent/CA2744921C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/095Neisseria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2744921A 2000-02-28 2001-02-28 Hybrid expression of neisserial proteins Expired - Fee Related CA2744921C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0004695.3 2000-02-28
GB0004695A GB0004695D0 (en) 2000-02-28 2000-02-28 Protein expression
GB0027675.8 2000-11-13
GB0027675A GB0027675D0 (en) 2000-11-13 2000-11-13 Protein Expression
CA2400562A CA2400562C (en) 2000-02-28 2001-02-28 Hybrid expression of neisserial proteins

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2400562A Division CA2400562C (en) 2000-02-28 2001-02-28 Hybrid expression of neisserial proteins

Publications (2)

Publication Number Publication Date
CA2744921A1 CA2744921A1 (en) 2001-09-07
CA2744921C true CA2744921C (en) 2014-05-13

Family

ID=26243750

Family Applications (5)

Application Number Title Priority Date Filing Date
CA2875231A Abandoned CA2875231A1 (en) 2000-02-28 2001-02-28 Heterologous expression of neisserial proteins
CA2400570A Expired - Fee Related CA2400570C (en) 2000-02-28 2001-02-28 Heterologous expression of neisserial proteins
CA2689666A Expired - Fee Related CA2689666C (en) 2000-02-28 2001-02-28 Heterologous expression of neisserial proteins
CA2400562A Expired - Fee Related CA2400562C (en) 2000-02-28 2001-02-28 Hybrid expression of neisserial proteins
CA2744921A Expired - Fee Related CA2744921C (en) 2000-02-28 2001-02-28 Hybrid expression of neisserial proteins

Family Applications Before (4)

Application Number Title Priority Date Filing Date
CA2875231A Abandoned CA2875231A1 (en) 2000-02-28 2001-02-28 Heterologous expression of neisserial proteins
CA2400570A Expired - Fee Related CA2400570C (en) 2000-02-28 2001-02-28 Heterologous expression of neisserial proteins
CA2689666A Expired - Fee Related CA2689666C (en) 2000-02-28 2001-02-28 Heterologous expression of neisserial proteins
CA2400562A Expired - Fee Related CA2400562C (en) 2000-02-28 2001-02-28 Hybrid expression of neisserial proteins

Country Status (19)

Country Link
US (9) US7803387B2 (enExample)
EP (6) EP1790660B1 (enExample)
JP (8) JP4846160B2 (enExample)
CN (7) CN1800385B (enExample)
AT (3) ATE503837T1 (enExample)
AU (4) AU3947801A (enExample)
BR (2) BR0108713A (enExample)
CA (5) CA2875231A1 (enExample)
CY (6) CY1106532T1 (enExample)
DE (3) DE60132978T2 (enExample)
DK (4) DK1790660T3 (enExample)
ES (5) ES2299476T3 (enExample)
LU (1) LU92240I2 (enExample)
MX (2) MXPA02008313A (enExample)
NL (1) NL300605I2 (enExample)
NZ (2) NZ521396A (enExample)
PT (4) PT1261723E (enExample)
RU (2) RU2299906C2 (enExample)
WO (2) WO2001064920A2 (enExample)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
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