CA2616395C - B-cell reduction using cd37-specific and cd20-specific binding molecules - Google Patents
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| CA2616395A1 CA2616395A1 (en) | 2007-02-01 |
| CA2616395C true CA2616395C (en) | 2016-10-04 |
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| US7829084B2 (en) * | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| US7754208B2 (en) * | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US8563592B2 (en) | 2001-11-01 | 2013-10-22 | Spectrum Pharmaceuticals, Inc. | Bladder cancer treatment and methods |
| CA2789114C (en) | 2001-11-01 | 2014-03-25 | Spectrum Pharmaceuticals, Inc. | Medical compositions for intravesical treatment of bladder cancer |
| SI1912675T1 (sl) | 2005-07-25 | 2014-07-31 | Emergent Product Development Seattle, Llc | zmanjĆĄanje ĆĄtevila celic B z uporabo molekul, ki se specifiÄno veĆŸejo na CD37 in CD20 |
| EP1986640A1 (en) * | 2006-02-09 | 2008-11-05 | Spectrum Pharmaceuticals, Inc. | Bladder cancer treatment by using e09 and propylene glycol |
| ES2363891T3 (es) | 2006-03-20 | 2011-08-18 | The Regents Of The University Of California | Anticuerpos contra el antĂgeno de cĂ©lulas troncales de la prĂłstata (psca) modificados genĂ©ticamente para el direccionamiento al cĂĄncer. |
| EP2418223A3 (en) | 2006-06-12 | 2013-01-16 | Emergent Product Development Seattle, LLC | Single-chain multivalent binding proteins with effector function |
| CN101646688A (zh) * | 2006-10-24 | 2010-02-10 | çčéČæŻæèŻćć Źćž | ć©çšæ çČŸèșæé«æäœäŸè”æ§ç»èæŻæ§çæčæł |
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| BRPI0812562A2 (pt) * | 2007-06-12 | 2019-09-24 | Trubion Pharmaceuticals Inc | composiçÔes terapĂȘuticas anti-cd20 e mĂ©todos |
| PE20140196A1 (es) | 2007-08-09 | 2014-03-19 | Boehringer Ingelheim Int | Anticuerpos anti-cd37 |
| US8940298B2 (en) | 2007-09-04 | 2015-01-27 | The Regents Of The University Of California | High affinity anti-prostate stem cell antigen (PSCA) antibodies for cancer targeting and detection |
| US20110245473A1 (en) | 2007-09-26 | 2011-10-06 | Chugai Seiyaku Kabushiki Kaisha | Anti-IL-6 Receptor Antibody |
| CN106519025B (zh) | 2007-09-26 | 2021-04-23 | äžć€ć¶èŻæ ȘćŒäŒç€Ÿ | ć©çšcdrçæ°šćșé žć代æ„æčćæäœçç”çčçæčæł |
| CA2700410C (en) * | 2007-10-03 | 2020-10-06 | Cornell University | Treatment of proliferative disorders using antibodies to psma |
| JP2011507897A (ja) * | 2007-12-21 | 2011-03-10 | ăžă§ăăłăăăŻïŒ ă€ăłăłăŒăăŹă€ăăă | ăȘăăă·ăăæ”ææ§éąçŻăȘăŠăăæŁè ăźæČ»ç |
| SG189772A1 (en) * | 2008-04-11 | 2013-05-31 | Trubion Pharmaceuticals Inc | Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof |
| CA2721052C (en) | 2008-04-11 | 2023-02-21 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| US20090269339A1 (en) * | 2008-04-29 | 2009-10-29 | Genentech, Inc. | Responses to immunizations in rheumatoid arthritis patients treated with a cd20 antibody |
| WO2010002862A2 (en) * | 2008-07-01 | 2010-01-07 | Aveo Pharmaceuticals, Inc. | Fibroblast growth factor receptor 3 (fgfr3) binding proteins |
| US20100069616A1 (en) * | 2008-08-06 | 2010-03-18 | The Regents Of The University Of California | Engineered antibody-nanoparticle conjugates |
| BRPI0921006A2 (pt) * | 2008-11-13 | 2015-12-15 | Emergent Product Dev Seattle | terapias imunoterapĂȘuticas combinadas de cd37 e usos destas |
| WO2010075249A2 (en) | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists |
| EP2398504B1 (en) * | 2009-02-17 | 2018-11-28 | Cornell Research Foundation, Inc. | Methods and kits for diagnosis of cancer and prediction of therapeutic value |
| US9493578B2 (en) | 2009-09-02 | 2016-11-15 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
| SG10201912571XA (en) | 2009-11-02 | 2020-02-27 | Univ Washington | Therapeutic nuclease compositions and methods |
| WO2011069019A2 (en) | 2009-12-02 | 2011-06-09 | David Ho | J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen (psma) and methods for their use |
| NO331080B1 (no) | 2010-01-29 | 2011-09-26 | Nordic Nanovector As | Radioimmunkonjugater, farmasĂžytiske sammensetninger og kit omfattende det samme og anvendelse derav |
| US9260529B2 (en) * | 2010-02-24 | 2016-02-16 | The University Of Washington Through Its Center For Commercialization | Molecules that bind CD180, compositions and methods of use |
| CN106046159B (zh) | 2010-03-12 | 2020-06-16 | ćŸ·ćœȘćć§ćœé æéć Źćž | Cd37ç»ććććć ¶ć ç«çŒćç© |
| US20120189618A1 (en) * | 2010-07-16 | 2012-07-26 | Boehringer Ingelheim International Gmbh | Superior efficacy of cd37 antibodies in cll blood samples |
| EP3029066B1 (en) | 2010-07-29 | 2019-02-20 | Xencor, Inc. | Antibodies with modified isoelectric points |
| EP2694105A4 (en) | 2011-04-01 | 2015-04-29 | Immunogen Inc | CD37 BINDING MOLECULES AND IMMUNOCONJUGATES THEREOF |
| US20140161800A1 (en) | 2011-04-22 | 2014-06-12 | John W. Blankenship | Prostate-Specific Membrane Antigen Binding Proteins and Related Compositions and Methods |
| KR20250037576A (ko) | 2011-04-29 | 2025-03-17 | ì ëëČìí° ì€ëž ìì±í€ ì€ëŁš ìŽìž ìŒí° íŹ ì»€ëšžì 늏ì ìŽì | ìčëŁì ëŽíŽë ìì ìĄ°ì±ëŹŒ ë° ë°©ëČ |
| US10851178B2 (en) | 2011-10-10 | 2020-12-01 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| US12466897B2 (en) | 2011-10-10 | 2025-11-11 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
| RU2658438C2 (ru) * | 2011-12-13 | 2018-06-21 | ĐĐŸŃĐŽĐžĐș ĐĐ°ĐœĐŸĐČĐ”ĐșŃĐŸŃ ĐŃĐ° | Đ„ĐžĐŒĐ”ŃĐœĐŸĐ” ŃĐ”ŃапДĐČŃĐžŃĐ”ŃĐșĐŸĐ” Đ°ĐœŃĐžŃĐ”Đ»ĐŸ ĐœĐœ1 ĐżŃĐŸŃĐžĐČ cd-37 |
| JP2015516980A (ja) * | 2012-04-26 | 2015-06-18 | ăăŒăȘăłăŹăŒ ă€ăłăČă«ăă€ă ă€ăłăżăŒăă·ă§ăă« ăČăŒă«ă·ăŁăă ăăă ăă·ă„ăŹăłăŻăă« ăăăăłă° | ïŒŁïœïŒïŒæäœăšăăłăă ăčăăłăšăźäœ”çš |
| US8992915B2 (en) * | 2012-05-16 | 2015-03-31 | Boehringer Ingelheim International Gmbh | Combination of CD37 antibodies with ICE |
| EP2849783A1 (en) * | 2012-05-16 | 2015-03-25 | Boehringer Ingelheim International GmbH | Combination of cd37 antibodies with further agents |
| WO2014100746A2 (en) * | 2012-12-21 | 2014-06-26 | The Regents Of The University Of California | Tspan 33 is a candidate for antibody targeted therapy for the treatment of b cell hodgkin lymphomas |
| US10131710B2 (en) | 2013-01-14 | 2018-11-20 | Xencor, Inc. | Optimized antibody variable regions |
| US9605084B2 (en) | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
| US10487155B2 (en) | 2013-01-14 | 2019-11-26 | Xencor, Inc. | Heterodimeric proteins |
| CA2898100C (en) | 2013-01-14 | 2023-10-10 | Xencor, Inc. | Novel heterodimeric proteins |
| US11053316B2 (en) | 2013-01-14 | 2021-07-06 | Xencor, Inc. | Optimized antibody variable regions |
| US10968276B2 (en) | 2013-03-12 | 2021-04-06 | Xencor, Inc. | Optimized anti-CD3 variable regions |
| US9701759B2 (en) | 2013-01-14 | 2017-07-11 | Xencor, Inc. | Heterodimeric proteins |
| WO2014113510A1 (en) | 2013-01-15 | 2014-07-24 | Xencor, Inc. | Rapid clearance of antigen complexes using novel antibodies |
| EP3421495A3 (en) | 2013-03-15 | 2019-05-15 | Xencor, Inc. | Modulation of t cells with bispecific antibodies and fc fusions |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| US10106624B2 (en) | 2013-03-15 | 2018-10-23 | Xencor, Inc. | Heterodimeric proteins |
| US10519242B2 (en) | 2013-03-15 | 2019-12-31 | Xencor, Inc. | Targeting regulatory T cells with heterodimeric proteins |
| US10228452B2 (en) | 2013-06-07 | 2019-03-12 | Hand Held Products, Inc. | Method of error correction for 3D imaging device |
| US20160101199A1 (en) * | 2013-06-07 | 2016-04-14 | Nordic Nanovector As | Method for upregulating antigen expression |
| CN105722534B (zh) | 2013-08-01 | 2019-05-31 | èŸæŽæŻćžèĄä»œæéć Źćž | ç»ćcd37èçœçæäœèŻç©ć¶èç©(adc) |
| CN105814594A (zh) * | 2013-10-30 | 2016-07-27 | çŻèć Źćž | çšäșćșŠéè„éäžćčżć掻ćšçæææ§ççł»ç»ćæčæł |
| WO2015066550A1 (en) | 2013-10-31 | 2015-05-07 | Resolve Therapeutics, Llc | Therapeutic nuclease-albumin fusions and methods |
| MX385936B (es) | 2014-03-28 | 2025-03-11 | Xencor Inc | Anticuerpos biespecĂficos que se unen a cd38 y cd3. |
| JP6600651B2 (ja) * | 2014-06-16 | 2019-10-30 | ăăš ăăĄăŠăłăăŒă·ă§ăł ăă©ăŒ ăĄăăŁă«ă« ăšăă„ă±ăŒă·ă§ăł ăąăłă ăȘă”ăŒă | éȘšé«è «ăźæČ»ç |
| MX2017006918A (es) | 2014-11-26 | 2018-01-25 | Xencor Inc | Anticuerpos heterodimericos que se unen a cd3 y cd38. |
| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| HRP20211273T1 (hr) | 2014-11-26 | 2021-11-12 | Xencor, Inc. | Heterodimerna protutijela koja veĆŸu cd3 i cd20 |
| EP3237449A2 (en) | 2014-12-22 | 2017-11-01 | Xencor, Inc. | Trispecific antibodies |
| WO2016141387A1 (en) | 2015-03-05 | 2016-09-09 | Xencor, Inc. | Modulation of t cells with bispecific antibodies and fc fusions |
| CA2986437A1 (en) | 2015-06-08 | 2016-12-15 | Debiopharm International, S.A. | Anti-cd37 immunoconjugate and anti-cd20 antibody combinations |
| NZ739721A (en) | 2015-08-07 | 2019-09-27 | Imaginab Inc | Antigen binding constructs to target molecules |
| WO2017040247A1 (en) | 2015-08-28 | 2017-03-09 | Immunogen, Inc. | Antibodies and assays for detection of cd37 |
| UA126278C2 (uk) | 2015-09-21 | 2022-09-14 | ĐĐżŃĐ”ĐČĐŸ Đ ŃŃŃĐŸŃŃ ĐĐœĐŽ ĐĐ”ĐČĐ”Đ»ĐŸĐżĐŒĐ”ĐœŃ ĐĐ»Ń | ĐĐŸĐ»ŃпДпŃОЎО, ŃĐșŃ Đ·ĐČ'ŃĐ·ŃŃŃŃ cd3 |
| JP7058219B2 (ja) | 2015-12-07 | 2022-04-21 | ăŒăłăłăą ă€ăłăłăŒăăŹă€ăăă | ïŒŁïœïŒćăłïœïœïœïœă«ç”ćăăăăăäșéäœæäœ |
| US20170174781A1 (en) * | 2015-12-22 | 2017-06-22 | Regeneron Pharmaceuticals, Inc. | Bispecific Anti-CD20/Anti-CD3 Antibodies to Treat Acute Lymphoblastic Leukemia |
| FI3468586T3 (fi) | 2016-06-14 | 2024-10-29 | Xencor Inc | BispesifisiÀ immuuniaktivaatiota vapauttavia vasta-aineita |
| EP3475304B1 (en) | 2016-06-28 | 2022-03-23 | Xencor, Inc. | Heterodimeric antibodies that bind somatostatin receptor 2 |
| US20190241878A1 (en) | 2016-07-01 | 2019-08-08 | Resolve Therapeutics, Llc | Optimized binuclease fusions and methods |
| US10793632B2 (en) | 2016-08-30 | 2020-10-06 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
| CA3040504A1 (en) | 2016-10-14 | 2018-04-19 | Xencor, Inc. | Il15/il15ra heterodimeric fc-fusion proteins |
| WO2018083633A1 (en) | 2016-11-02 | 2018-05-11 | Debiopharm International, S.A. | Methods for improving anti-cd37 immunoconjugate therapy |
| WO2018106931A1 (en) | 2016-12-07 | 2018-06-14 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
| EP3559044A4 (en) * | 2016-12-23 | 2020-12-02 | REMD Biotherapeutics, Inc. | IMMUNOTHERAPY USING ANTIBODIES THAT BINDING PROGRAMMED CELL DEATH 1 (PD-1) |
| WO2018132506A1 (en) | 2017-01-10 | 2018-07-19 | The General Hospital Corporation | Chimeric antigen receptors based on alternative signal 1 domains |
| US11266745B2 (en) | 2017-02-08 | 2022-03-08 | Imaginab, Inc. | Extension sequences for diabodies |
| CA3054632A1 (en) | 2017-03-30 | 2018-10-04 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immune modulatory agent released using an ingestible device |
| KR102706161B1 (ko) * | 2017-03-31 | 2024-09-19 | ì 맔 íë© ëč.ëžìŽ. | ìŽì€íčìŽì í-cd37 íìČŽ, ëȘšë žíŽëĄë í-cd37 íìČŽ ë° ê·žì ìŹì© ë°©ëČ |
| MA49517A (fr) | 2017-06-30 | 2020-05-06 | Xencor Inc | Protéines de fusion fc hétérodimÚres ciblées contenant il-15/il-15ra et domaines de liaison à l'antigÚne |
| CA3073537A1 (en) | 2017-08-22 | 2019-02-28 | Sanabio, Llc | Soluble interferon receptors and uses thereof |
| US10981992B2 (en) | 2017-11-08 | 2021-04-20 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
| WO2019094637A1 (en) | 2017-11-08 | 2019-05-16 | Xencor, Inc. | Bispecific and monospecific antibodies using novel anti-pd-1 sequences |
| KR102722731B1 (ko) | 2017-12-19 | 2024-10-25 | ì ìœìŽ ìžìœíŹë ìŽí°ë | ìĄ°ìë il-2 fc ì”í© ëšë°±ì§ |
| CN112469477A (zh) | 2018-04-04 | 2021-03-09 | XencorèĄä»œæéć Źćž | äžæçș€ç»Žç»è掻ćèçœç»ćçćŒæșäșèäœæäœ |
| CA3097741A1 (en) | 2018-04-18 | 2019-10-24 | Xencor, Inc. | Tim-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and tim-3 antigen binding domains |
| JP2021521784A (ja) | 2018-04-18 | 2021-08-30 | ăŒăłăłăą ă€ăłăłăŒăăŹă€ăăă | ïŒ©ïŒŹâïŒïŒïŒïŒ©ïŒŹâïŒïŒïŒČïœïŒŠïœèćăżăłăăŻèłȘăšïŒ°ïŒ€âïŒæćç”ćăăĄă€ăłăć«ăâïŒæšçćăăăăă€ăăŒèćăżăłăăŻèłȘăăăłăăăăźäœżçš |
| ES2714952B2 (es) * | 2018-05-18 | 2020-07-10 | Productos Agrovin S A | Procedimiento y equipo para el remontado durante la maceracion de la vendimia |
| MX2020012755A (es) | 2018-05-30 | 2021-02-26 | Debiopharm Int Sa | Regimenes de dosificacion del inmunoconjugado anti antigeno leucocitario (cd37). |
| US12227565B2 (en) | 2018-06-20 | 2025-02-18 | Biora Therapeutics, Inc. | Method of formulating a pharmaceutical composition comprising administering an immune modulator to the small intestine |
| WO2019246312A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
| AU2019290230A1 (en) * | 2018-06-22 | 2020-12-03 | The General Hospital Corporation | Chimeric antigen receptors targeting CD37 and CD19 |
| WO2020004337A1 (ja) * | 2018-06-27 | 2020-01-02 | ćœç«ć€§ćŠæłäșșćć€ć±ć€§ćŠ | ïŒŁïœïŒïŒçčç°çăăĄă©æćăŹă»ăăżăŒ |
| SG11202103192RA (en) | 2018-10-03 | 2021-04-29 | Xencor Inc | Il-12 heterodimeric fc-fusion proteins |
| CN116726361A (zh) | 2018-11-19 | 2023-09-12 | æŻć„„ææČ»çèĄä»œæéć Źćž | çšçç©æČ»çćæČ»ççŸç çæčæłćèŁ çœź |
| MX2021010390A (es) | 2019-03-01 | 2021-11-17 | Xencor Inc | Anticuerpos heterodimericos que se unen a enpp3 y cd3. |
| EP3998287A4 (en) * | 2019-07-08 | 2023-08-09 | Nanjing GenScript Biotech Co., Ltd. | ANTI-CD47/ANTI-PD-1 BISPECIFIC ANTIBODY, METHOD FOR PREPARATION AND USE |
| US11707610B2 (en) | 2019-12-13 | 2023-07-25 | Biora Therapeutics, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
| WO2021231976A1 (en) | 2020-05-14 | 2021-11-18 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3 |
| CN113980130B (zh) * | 2020-07-27 | 2023-07-21 | æčćèżæł°çç©ææŻæéć Źćž | äșșæșćcd37ććçčćŒæ§cd19-äșșæșćcd37 car-tç»è |
| CN117157319A (zh) | 2021-03-09 | 2023-12-01 | XencorèĄä»œæéć Źćž | ç»ćcd3ćcldn6çćŒäșèæäœ |
| KR20230154311A (ko) | 2021-03-10 | 2023-11-07 | ì ìœìŽ ìžìœíŹë ìŽí°ë | Cd3 ë° gpc3ì êČ°í©íë ìŽìą ìŽëìČŽ íìČŽ |
| CN118339188A (zh) | 2021-09-21 | 2024-07-12 | éœéČæźćæčŸçç©æČ»çć Źćž | çšäșć¶ć€èćèçœććçčćŒæ§æäœçćŒäșèäœFc |
| CA3235358A1 (en) | 2021-10-18 | 2023-04-27 | Daiichi Sankyo Company, Limited | Anti-cd37 antibody-drug conjugate |
| WO2023133488A1 (en) * | 2022-01-06 | 2023-07-13 | The General Hospital Corporation | Methods of cell ablation |
Family Cites Families (418)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA737247B (en) | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
| US3927193A (en) | 1973-05-18 | 1975-12-16 | Hoffmann La Roche | Localization of tumors by radiolabelled antibodies |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | ćłăźçŽ æ ȘćŒäŒç€Ÿ | 代çšèĄæ¶Č |
| US4361544A (en) | 1980-03-03 | 1982-11-30 | Goldenberg Milton David | Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers |
| US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
| US4460559A (en) | 1980-03-03 | 1984-07-17 | Goldenberg Milton David | Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers |
| US4444744A (en) | 1980-03-03 | 1984-04-24 | Goldenberg Milton David | Tumor localization and therapy with labeled antibodies to cell surface antigens |
| US4460561A (en) | 1980-03-03 | 1984-07-17 | Goldenberg M David | Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers |
| US4348376A (en) | 1980-03-03 | 1982-09-07 | Goldenberg Milton David | Tumor localization and therapy with labeled anti-CEA antibody |
| US4316885A (en) | 1980-08-25 | 1982-02-23 | Ayerst, Mckenna And Harrison, Inc. | Acyl derivatives of rapamycin |
| US4468457A (en) | 1981-06-01 | 1984-08-28 | David M. Goldenberg | Method for producing a CSAp tryptic peptide and anti-CSAp antibodies |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4769330A (en) | 1981-12-24 | 1988-09-06 | Health Research, Incorporated | Modified vaccinia virus and methods for making and using the same |
| US4818709A (en) | 1983-01-21 | 1989-04-04 | Primus Frederick J | CEA-family antigens, Anti-CEA antibodies and CEA immunoassay |
| US4460459A (en) | 1983-02-16 | 1984-07-17 | Anschutz Mining Corporation | Sequential flotation of sulfide ores |
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4624846A (en) | 1983-07-29 | 1986-11-25 | Immunomedics, Inc. | Method for enhancing target specificity of antibody localization and clearance of non-target diagnostic and therapeutic principles |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| US4782840A (en) | 1984-03-02 | 1988-11-08 | Neoprobe Corporation | Method for locating, differentiating, and removing neoplasms |
| US4935495A (en) * | 1984-12-21 | 1990-06-19 | Oncogen | Monoclonal antibodies to the L6 glycolipid antigenic determinant found on human non-small cell lung carcinomas |
| US4906562A (en) * | 1984-12-21 | 1990-03-06 | Oncogen | Monocolonal antibodies and antigen for human non-small cell lung carcinomas |
| GB8508845D0 (en) | 1985-04-04 | 1985-05-09 | Hoffmann La Roche | Vaccinia dna |
| EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| US5656266A (en) * | 1985-11-19 | 1997-08-12 | Schering Corporation | Method of using interleukin-4 |
| US4650803A (en) | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
| US5225539A (en) * | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US4704692A (en) | 1986-09-02 | 1987-11-03 | Ladner Robert C | Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides |
| US5869620A (en) * | 1986-09-02 | 1999-02-09 | Enzon, Inc. | Multivalent antigen-binding proteins |
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| US6893625B1 (en) * | 1986-10-27 | 2005-05-17 | Royalty Pharma Finance Trust | Chimeric antibody with specificity to human B cell surface antigen |
| US4932412A (en) | 1986-12-18 | 1990-06-12 | Immunomedics, Inc. | Intraoperative and endoscopic tumor detection and therapy |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| US5892019A (en) * | 1987-07-15 | 1999-04-06 | The United States Of America, As Represented By The Department Of Health And Human Services | Production of a single-gene-encoded immunoglobulin |
| US4897268A (en) | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
| WO1989001973A2 (en) | 1987-09-02 | 1989-03-09 | Applied Biotechnology, Inc. | Recombinant pox virus for immunization against tumor-associated antigens |
| US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
| GB8720833D0 (en) | 1987-09-04 | 1987-10-14 | Celltech Ltd | Recombinant dna product |
| JP3095168B2 (ja) | 1988-02-05 | 2000-10-03 | ăšă«ïŒ ăąăȘăœăłïŒă·ă§ăȘăŒ | ăăĄă€ăłâć€æ§äžć€éšăæăăæäœ |
| IL89220A (en) | 1988-02-11 | 1994-02-27 | Bristol Myers Squibb Co | Anthracycline immunoconjugates, their production and pharmaceutical compositions containing them |
| HUT53672A (en) | 1988-02-25 | 1990-11-28 | Gen Hospital Corp | Quick immunoselective cloning process |
| US5506126A (en) | 1988-02-25 | 1996-04-09 | The General Hospital Corporation | Rapid immunoselection cloning method |
| US4861579A (en) | 1988-03-17 | 1989-08-29 | American Cyanamid Company | Suppression of B-lymphocytes in mammals by administration of anti-B-lymphocyte antibodies |
| US5601819A (en) | 1988-08-11 | 1997-02-11 | The General Hospital Corporation | Bispecific antibodies for selective immune regulation and for selective immune cell binding |
| US6352694B1 (en) * | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| CA2006408A1 (en) | 1988-12-27 | 1990-06-27 | Susumu Iwasa | Bispecific monoclonal antibody, its production and use |
| US5217713A (en) | 1988-12-27 | 1993-06-08 | Takeda Chemical Industries, Ltd. | Cytotoxic bispecific monoclonal antibody, its production and use |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| WO1990007936A1 (en) | 1989-01-23 | 1990-07-26 | Chiron Corporation | Recombinant therapies for infection and hyperproliferative disorders |
| US5098833A (en) * | 1989-02-23 | 1992-03-24 | Genentech, Inc. | DNA sequence encoding a functional domain of a lymphocyte homing receptor |
| US5225538A (en) * | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5897861A (en) | 1989-06-29 | 1999-04-27 | Medarex, Inc. | Bispecific reagents for AIDS therapy |
| DE69029036T2 (de) | 1989-06-29 | 1997-05-22 | Medarex Inc | Bispezifische reagenzien fĂŒr die aids-therapie |
| US5980896A (en) | 1989-06-30 | 1999-11-09 | Bristol-Myers Squibb Company | Antibodies reactive with human carcinomas |
| US6020145A (en) | 1989-06-30 | 2000-02-01 | Bristol-Myers Squibb Company | Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96 |
| EP1645635A3 (en) | 1989-08-18 | 2010-07-07 | Oxford Biomedica (UK) Limited | Replication defective recombinant retroviruses expressing a palliative |
| US5605690A (en) * | 1989-09-05 | 1997-02-25 | Immunex Corporation | Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor |
| ATE228566T1 (de) | 1989-09-20 | 2002-12-15 | Abbott Lab | Verfahren zur herstellung von fusionsproteinen |
| US6018031A (en) | 1989-10-20 | 2000-01-25 | Trustees Of Dartmouth College | Binding agents specific for IgA receptor |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5314995A (en) * | 1990-01-22 | 1994-05-24 | Oncogen | Therapeutic interleukin-2-antibody based fusion proteins |
| AU645783B2 (en) | 1990-01-23 | 1994-01-27 | Tanox Biosystems, Inc. | Extracellular segments of human epsilon immunoglobulin anchoring peptides and antibodies specific therefor |
| CA2077348A1 (en) | 1990-03-02 | 1991-09-03 | Stephen D. Gillies | Antibody constructs with enhanced binding affinity |
| US20030219446A1 (en) | 1990-03-26 | 2003-11-27 | Bristol-Myers Squibb Company | Ligand for CD28 receptor on B cells and methods |
| US5580756A (en) | 1990-03-26 | 1996-12-03 | Bristol-Myers Squibb Co. | B7Ig fusion protein |
| GB9009106D0 (en) | 1990-04-23 | 1990-06-20 | 3I Res Expl Ltd | Processes and intermediates for synthetic antibody derivatives |
| EP0537293A4 (en) | 1990-07-02 | 1993-09-08 | Bristol-Myers Company | Ligand for cd28 receptor on b cells and methods |
| US5023264A (en) | 1990-07-16 | 1991-06-11 | American Home Products Corporation | Rapamycin oximes |
| US5023263A (en) | 1990-08-09 | 1991-06-11 | American Home Products Corporation | 42-oxorapamycin |
| US5130307A (en) | 1990-09-28 | 1992-07-14 | American Home Products Corporation | Aminoesters of rapamycin |
| US5221670A (en) | 1990-09-19 | 1993-06-22 | American Home Products Corporation | Rapamycin esters |
| US5233036A (en) | 1990-10-16 | 1993-08-03 | American Home Products Corporation | Rapamycin alkoxyesters |
| EP0557300B1 (en) | 1990-10-29 | 1997-11-19 | Chiron Corporation | Bispecific antibodies, method of production, and uses thereof |
| US5709859A (en) * | 1991-01-24 | 1998-01-20 | Bristol-Myers Squibb Company | Mixed specificity fusion proteins |
| EP0585257A4 (en) | 1991-03-28 | 1995-02-22 | Univ Minnesota | DNA AND AMINO ACID SEQUENCE SPECIFIC TO NATURAL K KILLER CELLS. |
| US5120842A (en) | 1991-04-01 | 1992-06-09 | American Home Products Corporation | Silyl ethers of rapamycin |
| US5100883A (en) | 1991-04-08 | 1992-03-31 | American Home Products Corporation | Fluorinated esters of rapamycin |
| US5118678A (en) | 1991-04-17 | 1992-06-02 | American Home Products Corporation | Carbamates of rapamycin |
| US5118677A (en) | 1991-05-20 | 1992-06-02 | American Home Products Corporation | Amide esters of rapamycin |
| JPH06508133A (ja) | 1991-05-31 | 1994-09-14 | ăžă§ăăłăăŻïŒă€ăłăłăŒăăŹă€ăăă | ïœïœă«éąéŁăăć ç«æ§ăźèĄć°æżæžć°æ§çŽ«æç ăźæČ»ç |
| DE4118120A1 (de) | 1991-06-03 | 1992-12-10 | Behringwerke Ag | Tetravalente bispezifische rezeptoren, ihre herstellung und verwendung |
| US5851795A (en) | 1991-06-27 | 1998-12-22 | Bristol-Myers Squibb Company | Soluble CTLA4 molecules and uses thereof |
| US5770197A (en) * | 1991-06-27 | 1998-06-23 | Bristol-Myers Squibb Company | Methods for regulating the immune response using B7 binding molecules and IL4-binding molecules |
| US6090914A (en) | 1991-06-27 | 2000-07-18 | Bristol-Myers Squibb Company | CTLA4/CD28Ig hybrid fusion proteins and uses thereof |
| US5844095A (en) | 1991-06-27 | 1998-12-01 | Bristol-Myers Squibb Company | CTLA4 Ig fusion proteins |
| US5637481A (en) | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
| KR100238712B1 (ko) | 1991-06-27 | 2000-01-15 | ì€í°ëž ëč. ë°ìŽëčì€ | ìší°ìììŽ4 ìì©ìČŽ,ê·žë„Œ íšì í ì°í©ëšë°±ì§ ë° ê·žì ì©ë |
| DE69207603T2 (de) | 1991-08-16 | 1996-09-12 | Vical Inc | Zusammensetzung und verfahren zur behandlung von zystischer fibrose |
| US5162333A (en) | 1991-09-11 | 1992-11-10 | American Home Products Corporation | Aminodiesters of rapamycin |
| US5962406A (en) * | 1991-10-25 | 1999-10-05 | Immunex Corporation | Recombinant soluble CD40 ligand polypeptide and pharmaceutical composition containing the same |
| US5151413A (en) | 1991-11-06 | 1992-09-29 | American Home Products Corporation | Rapamycin acetals as immunosuppressant and antifungal agents |
| EP0617706B1 (en) | 1991-11-25 | 2001-10-17 | Enzon, Inc. | Multivalent antigen-binding proteins |
| US6027725A (en) * | 1991-11-25 | 2000-02-22 | Enzon, Inc. | Multivalent antigen-binding proteins |
| ES2341666T3 (es) | 1991-12-02 | 2010-06-24 | Medimmune Limited | Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos. |
| CA2089229C (en) * | 1992-02-14 | 2010-04-13 | Alejandro A. Aruffo | Cd40cr receptor and ligands therefor |
| US6472510B1 (en) | 1992-02-14 | 2002-10-29 | Bristol-Myers Squibb Company | CD40 receptor ligands |
| US5177203A (en) | 1992-03-05 | 1993-01-05 | American Home Products Corporation | Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents |
| US6129914A (en) | 1992-03-27 | 2000-10-10 | Protein Design Labs, Inc. | Bispecific antibody effective to treat B-cell lymphoma and cell line |
| EP0650370A4 (en) | 1992-06-08 | 1995-11-22 | Univ California | METHODS AND COMPOSITIONS TARGETED ON SPECIFIC TISSUES. |
| WO1993025698A1 (en) | 1992-06-10 | 1993-12-23 | The United States Government As Represented By The | Vector particles resistant to inactivation by human serum |
| GB2269175A (en) | 1992-07-31 | 1994-02-02 | Imperial College | Retroviral vectors |
| US5256790A (en) | 1992-08-13 | 1993-10-26 | American Home Products Corporation | 27-hydroxyrapamycin and derivatives thereof |
| DK0586002T3 (da) | 1992-08-18 | 2000-06-19 | Centro Inmunologia Molecular | Monoklonale antistoffer, som genkender epidermisvÊkstfaktor-receptoren, celler og fremgangsmÄder heraf og prÊparater indeho |
| DE69330523D1 (de) | 1992-08-21 | 2001-09-06 | Vrije Universiteit Brussel Bru | Immunoglobuline ohne leichte ketten |
| ZA936260B (en) | 1992-09-09 | 1994-03-18 | Smithkline Beecham Corp | Novel antibodies for conferring passive immunity against infection by a pathogen in man |
| US6066718A (en) | 1992-09-25 | 2000-05-23 | Novartis Corporation | Reshaped monoclonal antibodies against an immunoglobulin isotype |
| GB9221220D0 (en) | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
| WO1994009034A1 (en) | 1992-10-12 | 1994-04-28 | Agen Limited | Clot directed anticoagulant, process for making same and methods of use |
| US5489680A (en) | 1992-10-13 | 1996-02-06 | American Home Products Corporation | Carbamates of rapamycin |
| US5302584A (en) | 1992-10-13 | 1994-04-12 | American Home Products Corporation | Carbamates of rapamycin |
| US5480988A (en) | 1992-10-13 | 1996-01-02 | American Home Products Corporation | Carbamates of rapamycin |
| US5411967A (en) | 1992-10-13 | 1995-05-02 | American Home Products Corporation | Carbamates of rapamycin |
| US5480989A (en) | 1992-10-13 | 1996-01-02 | American Home Products Corporation | Carbamates of rapamycin |
| US5434260A (en) | 1992-10-13 | 1995-07-18 | American Home Products Corporation | Carbamates of rapamycin |
| US5262423A (en) | 1992-10-29 | 1993-11-16 | American Home Products Corporation | Rapamycin arylcarbonyl and alkoxycarbonyl carbamates as immunosuppressive and antifungal agents |
| US5258389A (en) | 1992-11-09 | 1993-11-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives |
| DE69303494T2 (de) | 1992-11-13 | 1997-01-16 | Idec Pharma Corp | Therapeutische verwendung von chimerischen und markierten antikörper gegen menschlichen b lymphozyt beschrĂ€nkter differenzierung antigen fĂŒr die behandlung von b-zell-lymphoma |
| US5736137A (en) * | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| US5260300A (en) | 1992-11-19 | 1993-11-09 | American Home Products Corporation | Rapamycin carbonate esters as immuno-suppressant agents |
| DK0672142T3 (da) | 1992-12-04 | 2001-06-18 | Medical Res Council | Multivalente og multispecifikke bindingsproteiner samt fremstilling og anvendelse af disse |
| GB9225453D0 (en) | 1992-12-04 | 1993-01-27 | Medical Res Council | Binding proteins |
| US5773253A (en) * | 1993-01-22 | 1998-06-30 | Bristol-Myers Squibb Company | MYPPPY variants of CTL A4 and uses thereof |
| US6482919B2 (en) | 1993-02-01 | 2002-11-19 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
| US5597707A (en) * | 1993-04-15 | 1997-01-28 | Bristol-Myers Squibb Company | Tumor associated antigen recognized by the murine monoclonal antibody L6, its oligonucleotide sequence and methods for their use |
| US5504091A (en) | 1993-04-23 | 1996-04-02 | American Home Products Corporation | Biotin esters of rapamycin |
| ES2162863T3 (es) | 1993-04-29 | 2002-01-16 | Unilever Nv | Produccion de anticuerpos o fragmentos (funcionalizados) de los mismos derivados de inmunoglobulinas de cadena pesada de camelidae. |
| US5795572A (en) * | 1993-05-25 | 1998-08-18 | Bristol-Myers Squibb Company | Monoclonal antibodies and FV specific for CD2 antigen |
| US5747654A (en) | 1993-06-14 | 1998-05-05 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant disulfide-stabilized polypeptide fragments having binding specificity |
| US6476198B1 (en) | 1993-07-13 | 2002-11-05 | The Scripps Research Institute | Multispecific and multivalent antigen-binding polypeptide molecules |
| US5417972A (en) | 1993-08-02 | 1995-05-23 | The Board Of Trustees Of The Leland Stanford Junior University | Method of killing B-cells in a complement independent and an ADCC independent manner using antibodies which specifically bind CDIM |
| US5869049A (en) * | 1993-09-02 | 1999-02-09 | Trustees Of Dartmouth College | Methods of inducing T cell unresponsiveness to bone marrow with gp39 antagonists |
| NZ273221A (en) * | 1993-09-02 | 2001-09-28 | Dartmouth College | Pharmaceutical for inducing antigen-specific T cell tolerance |
| US5595721A (en) | 1993-09-16 | 1997-01-21 | Coulter Pharmaceutical, Inc. | Radioimmunotherapy of lymphoma using anti-CD20 |
| ES2126145T3 (es) | 1993-09-22 | 1999-03-16 | Medical Res Council | Redireccionamiento de anticuerpos. |
| GB9412166D0 (en) | 1993-09-22 | 1994-08-10 | Medical Res Council | Retargetting antibodies |
| WO1995009917A1 (en) | 1993-10-07 | 1995-04-13 | The Regents Of The University Of California | Genetically engineered bispecific tetravalent antibodies |
| US5391730A (en) | 1993-10-08 | 1995-02-21 | American Home Products Corporation | Phosphorylcarbamates of rapamycin and oxime derivatives thereof |
| US5373014A (en) | 1993-10-08 | 1994-12-13 | American Home Products Corporation | Rapamycin oximes |
| US5385910A (en) | 1993-11-22 | 1995-01-31 | American Home Products Corporation | Gem-distributed esters of rapamycin |
| US5385909A (en) | 1993-11-22 | 1995-01-31 | American Home Products Corporation | Heterocyclic esters of rapamycin |
| US5385908A (en) | 1993-11-22 | 1995-01-31 | American Home Products Corporation | Hindered esters of rapamycin |
| CZ284650B6 (cs) | 1993-12-17 | 1999-01-13 | Novartis Ag | NovĂ© demethoxyderivĂĄty rapamycinu, zpĆŻsob jejich pĆĂpravy a farmaceutickĂœ prostĆedek, kterĂœ je obsahuje |
| US5389639A (en) | 1993-12-29 | 1995-02-14 | American Home Products Company | Amino alkanoic esters of rapamycin |
| US6380369B1 (en) | 1994-01-27 | 2002-04-30 | Human Genome Sciences, Inc. | Human DNA mismatch repair proteins |
| AU689214B2 (en) * | 1994-02-01 | 1998-03-26 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Fusion proteins that include antibody and nonantibody portions |
| WO1995024220A1 (en) | 1994-03-07 | 1995-09-14 | Medarex, Inc. | Bispecific molecules having clinical utilities |
| RU2170257C2 (ru) | 1994-03-17 | 2001-07-10 | ĐĐ”ŃĐș ĐĐ°ŃĐ”ĐœŃ ĐĐŒĐ±Ń | ĐĐœŃĐž-ŃŃŃŃ ĐŸĐŽĐœĐŸŃĐ”ĐżĐŸŃĐ”ŃĐœŃĐč fv, Ń ĐžĐŒĐ”ŃĐœĐŸĐ” Đ°ĐœŃĐž-ŃŃŃŃ Đ°ĐœŃĐžŃĐ”Đ»ĐŸ Đž ŃĐżĐŸŃĐŸĐ± Đ”ĐłĐŸ ĐżĐŸĐ»ŃŃĐ”ĐœĐžŃ, ŃĐ°ŃĐŒĐ°ŃĐ”ĐČŃĐžŃĐ”ŃĐșĐ°Ń ĐșĐŸĐŒĐżĐŸĐ·ĐžŃĐžŃ ĐŽĐ»Ń Đ»Đ”ŃĐ”ĐœĐžŃ ĐŸĐżŃŃ ĐŸĐ»Đ”Đč, ŃŃДЎŃŃĐČĐŸ ĐŽĐ»Ń ĐŽĐžĐ°ĐłĐœĐŸŃŃĐžĐșĐž Đ»ĐŸĐșалОзаŃОО ОлО ĐŸŃĐ”ĐœĐșĐž ŃĐŸŃŃĐ° ĐŸĐżŃŃ ĐŸĐ»Đž |
| US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
| EP0758394B1 (en) | 1994-05-02 | 2002-11-20 | Bernd Groner | Bifunctional protein, preparation and use |
| US5945273A (en) | 1997-06-03 | 1999-08-31 | Human Genome Sciences, Inc. | Human oxalyl-coa decarboxylase |
| US5463048A (en) | 1994-06-14 | 1995-10-31 | American Home Products Corporation | Rapamycin amidino carbamates |
| US5888773A (en) * | 1994-08-17 | 1999-03-30 | The United States Of America As Represented By The Department Of Health And Human Services | Method of producing single-chain Fv molecules |
| US6384202B1 (en) | 1994-08-26 | 2002-05-07 | Hoechst Aktiengesellschaft | Cell-specific active compounds regulated by the cell cycle |
| US6380169B1 (en) | 1994-08-31 | 2002-04-30 | Isis Pharmaceuticals, Inc. | Metal complex containing oligonucleoside cleavage compounds and therapies |
| US5736524A (en) | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
| US5491231A (en) | 1994-11-28 | 1996-02-13 | American Home Products Corporation | Hindered N-oxide esters of rapamycin |
| US5563145A (en) | 1994-12-07 | 1996-10-08 | American Home Products Corporation | Rapamycin 42-oximes and hydroxylamines |
| US6383814B1 (en) | 1994-12-09 | 2002-05-07 | Genzyme Corporation | Cationic amphiphiles for intracellular delivery of therapeutic molecules |
| US5876950A (en) * | 1995-01-26 | 1999-03-02 | Bristol-Myers Squibb Company | Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy |
| EP0739981A1 (en) * | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| US6410690B1 (en) | 1995-06-07 | 2002-06-25 | Medarex, Inc. | Therapeutic compounds comprised of anti-Fc receptor antibodies |
| KR100400620B1 (ko) | 1995-06-09 | 2004-02-18 | ë žíë„Ží°ì€ ìêČ | ëŒíë§ìŽì ì ëìČŽ |
| GB9518220D0 (en) | 1995-09-06 | 1995-11-08 | Medical Res Council | Checkpoint gene |
| US5866330A (en) | 1995-09-12 | 1999-02-02 | The Johns Hopkins University School Of Medicine | Method for serial analysis of gene expression |
| JPH11513669A (ja) * | 1995-10-13 | 1999-11-24 | ăąăĄăȘă«ćèĄćœ | ăžăčă«ăăŁăćźćźćæäœăă©ă°ăĄăłăăć«ăć ç«æŻçŽ |
| US6440418B1 (en) | 1995-11-07 | 2002-08-27 | Idec Pharmaceuticals Corporation | Methods of treating autoimmune diseases with gp39-specific antibodies |
| US6379966B2 (en) | 1999-02-26 | 2002-04-30 | Mirus Corporation | Intravascular delivery of non-viral nucleic acid |
| US5780462A (en) | 1995-12-27 | 1998-07-14 | American Home Products Corporation | Water soluble rapamycin esters |
| US6750334B1 (en) | 1996-02-02 | 2004-06-15 | Repligen Corporation | CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor |
| GB2310894A (en) | 1996-03-06 | 1997-09-10 | Clive William Efford | Multi-engine drive unit |
| IL125928A (en) * | 1996-03-20 | 2002-11-10 | Bristol Myers Squibb Co | The use of soluble ligands that react with CTLA4, B7, CD40, gp39 and / or CD28 for the preparation of pharmaceutical preparations |
| EP1186300A1 (en) | 1996-03-20 | 2002-03-13 | Bristol-Myers Squibb Company | Pharmaceutical compositions useful for inhibiting an immune response by blocking the GP39/CD40 and CTLA4/CD28/B7 pathways |
| DE19613691A1 (de) | 1996-04-05 | 1997-10-09 | Boehringer Ingelheim Int | Arzneimittel fĂŒr die Behandlung von Tumorerkrankungen |
| US5922845A (en) | 1996-07-11 | 1999-07-13 | Medarex, Inc. | Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies |
| EP0912734B1 (en) * | 1996-07-12 | 2010-11-03 | Genentech, Inc. | Chimeric heteromultimer adhesins |
| EP0937082A2 (en) | 1996-07-12 | 1999-08-25 | Ariad Pharmaceuticals, Inc. | Materials and method for treating or preventing pathogenic fungal infection |
| WO1998002462A1 (en) | 1996-07-16 | 1998-01-22 | Morphosys Gesellschaft FĂŒr Proteinoptimierung Mbh | Immunoglobulin superfamily domains and fragments with increased solubility |
| US5846948A (en) | 1996-08-30 | 1998-12-08 | Arch Development Corporation | Herpes simplex virus ORF P is a repressor of viral protein synthesis |
| GB9618477D0 (en) | 1996-09-04 | 1996-10-16 | Univ Leeds | Gene therapy |
| US6368598B1 (en) | 1996-09-16 | 2002-04-09 | Jcrt Radiation Oncology Support Services, Inc. | Drug complex for treatment of metastatic prostate cancer |
| US5972361A (en) | 1996-10-25 | 1999-10-26 | The Procter & Gamble Company | Cleansing products |
| US5858753A (en) | 1996-11-25 | 1999-01-12 | Icos Corporation | Lipid kinase |
| DE19651443A1 (de) | 1996-12-11 | 1998-06-18 | Hoechst Ag | SelbstverstÀrkende, pharmakologisch kontrollierbare Expressionssysteme |
| KR19980066046A (ko) | 1997-01-18 | 1998-10-15 | ì ì©í | êł ìê°ì CTLA4-Ig ì”í©ëšë°±ì§ |
| EP0860445A1 (en) | 1997-02-18 | 1998-08-26 | Hoechst Aktiengesellschaft | New nucleotide sequences for the cell cycle regulated expression of structural genes |
| US6133426A (en) | 1997-02-21 | 2000-10-17 | Genentech, Inc. | Humanized anti-IL-8 monoclonal antibodies |
| RU2195946C2 (ru) | 1997-03-11 | 2003-01-10 | ĐĐ” ĐĐ°Đ±ĐŸŃĐ°ŃĐŸŃОз ĐĐ”ŃĐ”ŃĐœĐ° ĐĐœĐș. | ĐŃĐŸŃĐžĐČĐŸĐŸĐżŃŃ ĐŸĐ»Đ”ĐČŃĐ” ŃĐ”ŃапДĐČŃĐžŃĐ”ŃĐșОД ŃŃДЎŃŃĐČĐ°, ĐČĐșĐ»ŃŃĐ°ŃŃОД ĐșĐŸĐŒĐ±ĐžĐœĐ°ŃĐžŃ ŃĐșŃŃŃĐ°ĐșŃĐ° Ń ŃŃŃĐ° Đž Đ°ĐœŃĐžĐœĐ”ĐŸĐżĐ»Đ°ŃŃĐžŃĐ”ŃĐșĐŸĐłĐŸ Đ°ĐłĐ”ĐœŃĐ°, ĐŸĐ±Đ”ŃпДŃĐžĐČĐ°ŃŃОД ĐČŃŃĐŸĐșŃŃ ŃŃŃĐ”ĐșŃĐžĐČĐœĐŸŃŃŃ ĐŽĐ”ĐčŃŃĐČĐžŃ ĐżŃĐž ĐœĐžĐ·ĐșĐžŃ ŃĐŸĐșŃĐžŃĐ”ŃĐșĐžŃ ĐżĐŸĐ±ĐŸŃĐœŃŃ ŃŃŃĐ”ĐșŃĐ°Ń |
| IL131978A0 (en) | 1997-03-20 | 2001-03-19 | Univ Washington | Solvent for biopolymer synthesis solvent microdots and methods of use |
| US6306393B1 (en) | 1997-03-24 | 2001-10-23 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
| US6384203B1 (en) | 1999-05-12 | 2002-05-07 | Immunex Corporation | Family of immunoregulators designated leukocyte immunoglobulin-like receptors (LIR) |
| US6217900B1 (en) | 1997-04-30 | 2001-04-17 | American Home Products Corporation | Vesicular complexes and methods of making and using the same |
| US20020062010A1 (en) | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| JP3919235B2 (ja) | 1997-06-13 | 2007-05-23 | ăžă§ăăłăăŻïŒă€ăłăłăŒăăŹă€ăăă | æäœèŁœć€ |
| US6171586B1 (en) | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| JP2002506353A (ja) | 1997-06-24 | 2002-02-26 | ăžă§ăăłăăăŻă»ă€ăłăłăŒăăŹăŒăăă | ăŹă©ăŻăă·ă«ćçłăżăłăăŻèłȘăźæčæłćăłç”æç© |
| US5994511A (en) | 1997-07-02 | 1999-11-30 | Genentech, Inc. | Anti-IgE antibodies and methods of improving polypeptides |
| US6368596B1 (en) * | 1997-07-08 | 2002-04-09 | Board Of Regents, The University Of Texas System | Compositions and methods for homoconjugates of antibodies which induce growth arrest or apoptosis of tumor cells |
| US6165476A (en) | 1997-07-10 | 2000-12-26 | Beth Israel Deaconess Medical Center | Fusion proteins with an immunoglobulin hinge region linker |
| US6342220B1 (en) | 1997-08-25 | 2002-01-29 | Genentech, Inc. | Agonist antibodies |
| TW557297B (en) | 1997-09-26 | 2003-10-11 | Abbott Lab | Rapamycin analogs having immunomodulatory activity, and pharmaceutical compositions containing same |
| US6383746B1 (en) | 1997-10-23 | 2002-05-07 | The United States Of America As Represented By The Department Of Health And Human Services | Functional promoter for CCR5 |
| WO1999022764A1 (en) | 1997-10-31 | 1999-05-14 | Genentech, Inc. | Methods and compositions comprising glycoprotein glycoforms |
| US6383811B2 (en) | 1997-12-30 | 2002-05-07 | Mirus Corporation | Polyampholytes for delivering polyions to a cell |
| ATE283364T1 (de) | 1998-01-23 | 2004-12-15 | Vlaams Interuniv Inst Biotech | Mehrzweck-antikörperderivate |
| CN1316910A (zh) | 1998-02-19 | 2001-10-10 | ćć æŻè„żçčæČ»çć Źćž | çšäșè°èæ·ć·Žç»è掻ćçç»ćç©ćæčæł |
| US6051228A (en) * | 1998-02-19 | 2000-04-18 | Bristol-Myers Squibb Co. | Antibodies against human CD40 |
| CZ20003099A3 (cs) | 1998-02-25 | 2002-04-17 | Lexigen Pharmaceuticals Corporation | ZvĂœÄ enĂ doby poloviÄnĂ ÄŸivotnosti cirkulujĂcĂch fĂșznĂch proteinĆŻ odvozenĂœch od protilĂĄtek |
| US6383481B1 (en) | 1998-03-30 | 2002-05-07 | Japan Immunoresearch Laboratories Co., Ltd. | Method for transplantation of hemopoietic stem cells |
| US6242195B1 (en) * | 1998-04-02 | 2001-06-05 | Genentech, Inc. | Methods for determining binding of an analyte to a receptor |
| US6194551B1 (en) * | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| US6528624B1 (en) | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
| PT1068241E (pt) | 1998-04-02 | 2007-11-19 | Genentech Inc | Variantes de anticorpos e respectivos fragmentos |
| US6284536B1 (en) * | 1998-04-20 | 2001-09-04 | The Regents Of The University Of California | Modified immunoglobin molecules and methods for use thereof |
| EP1073721B1 (en) | 1998-04-22 | 2005-08-31 | Genvec, Inc. | Efficient purification of adenovirus |
| GB9809280D0 (en) | 1998-04-30 | 1998-07-01 | Rpms Technology Ltd | Immunosupression |
| DE19819846B4 (de) | 1998-05-05 | 2016-11-24 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Multivalente Antikörper-Konstrukte |
| WO1999061630A2 (en) | 1998-05-26 | 1999-12-02 | Regeneron Pharmaceuticals, Inc. | Chimeric molecules comprising an extracellular ligand binding domain of a receptor and an ige fc or constant region, and their use in an assay system |
| US7052872B1 (en) | 1999-06-22 | 2006-05-30 | Immunomedics, Inc. | Bi-specific antibodies for pre-targeting diagnosis and therapy |
| US6818213B1 (en) | 1998-07-13 | 2004-11-16 | Board Of Regents, The University Of Texas System | Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids |
| AU750414B2 (en) | 1998-07-13 | 2002-07-18 | Board Of Regents, The University Of Texas System | Cancer treatment methods using therapeutic conjugates that bind to aminophospholipids |
| DK1100830T3 (da) | 1998-07-28 | 2004-01-19 | Micromet Ag | Heterominiantistoffer |
| KR101063278B1 (ko) | 1998-08-11 | 2011-09-07 | ë°ìŽì€êČ ììŽë± ìžíŹ. | ïŒą-ìžíŹ 늌íìą ì ìčëŁíêž° ìí í-ïœïœïŒïŒ íìČŽë„Œ íŹíšíë ìœì |
| AU5689699A (en) | 1998-08-24 | 2000-03-14 | Uab Research Foundation | Methods of producing high titer recombinant adeno-associated virus |
| US6472179B2 (en) | 1998-09-25 | 2002-10-29 | Regeneron Pharmaceuticals, Inc. | Receptor based antagonists and methods of making and using |
| US6224866B1 (en) | 1998-10-07 | 2001-05-01 | Biocrystal Ltd. | Immunotherapy of B cell involvement in progression of solid, nonlymphoid tumors |
| AU2472400A (en) * | 1998-10-20 | 2000-05-08 | City Of Hope | CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| US6197294B1 (en) | 1998-10-26 | 2001-03-06 | Neurotech S.A. | Cell surface molecule-induced macrophage activation |
| WO2000027885A1 (en) | 1998-11-05 | 2000-05-18 | Kyowa Hakko Kogyo Co., Ltd. | Novel chimeric polypeptide |
| AU761516B2 (en) | 1998-11-09 | 2003-06-05 | Biogen Inc. | Chimeric anti-CD20 antibody treatment of patients receiving BMT or PBSC transplants |
| EP1131093A4 (en) | 1998-11-09 | 2002-05-02 | Idec Pharma Corp | TREATMENT OF HEMATOLOGICAL VILTIES ASSOCIATED WITH CIRCULATING TUMOR CELLS USING CHIMERIC ANTI-CD20 ANTIBODIES |
| US6380371B1 (en) | 1998-12-10 | 2002-04-30 | The Regents Of The University Of California | Endoglycan: a novel protein having selectin ligand and chemokine presentation activity |
| KR101077001B1 (ko) | 1999-01-15 | 2011-10-26 | ì ëší íŹ, ìžíŹ. | íšêłŒêž° êž°ë„ìŽ ëłíë íŽëŠŹí©í°ë ëłìŽìČŽ |
| US6897044B1 (en) | 1999-01-28 | 2005-05-24 | Biogen Idec, Inc. | Production of tetravalent antibodies |
| EP1151002A4 (en) | 1999-01-29 | 2002-05-02 | Imclone Systems Inc | KDR-SPECIFIC ANTIBODIES AND USES THEREOF |
| US6383276B1 (en) | 1999-03-12 | 2002-05-07 | Fuji Photo Film Co., Ltd. | Azomethine compound and oily magenta ink |
| US6383753B1 (en) | 1999-03-31 | 2002-05-07 | Regents Of The University Of Michigan | Yeast mammalian regulators of cell proliferation |
| WO2000064954A1 (en) | 1999-04-22 | 2000-11-02 | Vanderbilt University | Polymeric encapsulation system promoting angiogenesis |
| GB9909925D0 (en) * | 1999-04-29 | 1999-06-30 | Pharmacia & Upjohn Spa | Combined preparations comprising anthracycline derivatives |
| US6358596B1 (en) * | 1999-04-27 | 2002-03-19 | The Standard Register Company | Multi-functional transparent secure marks |
| KR20020027311A (ko) | 1999-05-07 | 2002-04-13 | ì ëší íŹ, ìžíŹ. | ïŒą ìžíŹ íë©Ž ë§ì»€ì êČ°í©íë êžžíëŹŒì§ì ìŽì©íìê°ë©Žì ì§íì ìčëŁ |
| US8119101B2 (en) | 1999-05-10 | 2012-02-21 | The Ohio State University | Anti-CD74 immunoconjugates and methods of use |
| DE60035871T2 (de) | 1999-05-19 | 2008-06-05 | Merck Patent Gmbh | Expression und export von interferon-alpha proteinen als fc fusionsproteine |
| EP1194167B1 (en) * | 1999-06-09 | 2009-08-19 | Immunomedics, Inc. | Immunotherapy of autoimmune disorders using antibodies which target b-cells |
| ITMI991299A1 (it) | 1999-06-11 | 2000-12-11 | Consiglio Nazionale Ricerche | Uso di anticorpi contro antigeni di superficie per il trattamento della malattia trapianto contro ospite |
| US6380382B1 (en) | 1999-06-30 | 2002-04-30 | Millennium Pharmaceuticals, Inc. | Gene encoding a protein having diagnostic, preventive, therapeutic, and other uses |
| DE19930748C2 (de) | 1999-07-02 | 2001-05-17 | Infineon Technologies Ag | Verfahren zur Herstellung von EEPROM- und DRAM-Grabenspeicherzellbereichen auf einem Chip |
| CN1373672A (zh) | 1999-07-12 | 2002-10-09 | æ°ćææŻć Źćž | ćșçšç»ćcd20çæźæćé»æćŻčć€æ„æćçć ç«ćșç |
| ES2277846T3 (es) | 1999-07-29 | 2007-08-01 | Medarex, Inc. | Anticuerpos monoclonales humanos para antigeno prostatico especifico. |
| IL147765A0 (en) | 1999-07-29 | 2002-08-14 | Medarex Inc | HUMAN MONOCLONAL ANTIBODIES TO HER2/neu |
| JP4308470B2 (ja) | 1999-07-30 | 2009-08-05 | ăĄăăŹăăŻăč ă€ăłăŻ | æïœććźčäœç”ćèŹăăăȘăæČ»ççšććç© |
| CN100389825C (zh) | 1999-08-11 | 2008-05-28 | æć„„æ čIdecć Źćž | çšæcd20æäœæČ»ç环ćéȘšé«çééć„éæ·ć·Žç€æŁè |
| US6451284B1 (en) | 1999-08-11 | 2002-09-17 | Idec Pharmaceuticals Corporation | Clinical parameters for determining hematologic toxicity prior to radioimmunotheraphy |
| US8557244B1 (en) | 1999-08-11 | 2013-10-15 | Biogen Idec Inc. | Treatment of aggressive non-Hodgkins lymphoma with anti-CD20 antibody |
| AU6929100A (en) | 1999-08-23 | 2001-03-19 | Biocrystal Limited | Methods and compositions for immunotherapy of b cell involvement in promotion ofa disease condition comprising multiple sclerosis |
| ES2219388T3 (es) | 1999-08-24 | 2004-12-01 | Ariad Gene Therapeutics, Inc. | 28-epi-rapalogos. |
| US20020006404A1 (en) * | 1999-11-08 | 2002-01-17 | Idec Pharmaceuticals Corporation | Treatment of cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications |
| US20020028178A1 (en) | 2000-07-12 | 2002-03-07 | Nabil Hanna | Treatment of B cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications |
| EP1229935A1 (en) | 1999-11-08 | 2002-08-14 | Idec Pharmaceuticals Corporation | Treatment of b cell malignancies using anti-cd40l antibodies in combination with anti-cd20 antibodies and/or chemotherapeutics and radiotherapy |
| US6380362B1 (en) | 1999-12-23 | 2002-04-30 | Genesis Research & Development Corporation Ltd. | Polynucleotides, polypeptides expressed by the polynucleotides and methods for their use |
| CA2397742A1 (en) | 2000-02-25 | 2001-08-30 | Health Research, Inc. | Method for transdermal sampling of analytes |
| CA2404390A1 (en) | 2000-03-24 | 2001-10-04 | Chiron Corporation | Methods of therapy for non-hodgkin's lymphoma using a combination of an antibody to cd20 and interleukin-2 |
| KR20020091170A (ko) | 2000-03-31 | 2002-12-05 | ììŽë± íë§ìí°ìčŒìŠ ìœíŹë ìŽì | ïŒą ìžíŹ 늌íìą ì ìčëŁë„Œ ìí í-ìŹìŽí ìčŽìž íìČŽ ëëêžžíì ë° í-ïœïœïŒïŒì ìĄ°í©ë ìŹì© |
| MXPA02010011A (es) | 2000-04-11 | 2003-04-25 | Genentech Inc | Anticuerpos multivalentes y usos para los mismos. |
| US6667300B2 (en) | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
| EP1278748B1 (en) | 2000-04-25 | 2011-03-23 | ICOS Corporation | Inhibitors of human phosphatidyl-inositol 3-kinase delta |
| EP1939203B1 (en) | 2000-04-25 | 2014-11-19 | ICOS Corporation | Inhibitors of human phosphatidyl-inositol 3-kinase delta isoform |
| BR0110364A (pt) | 2000-04-25 | 2003-12-30 | Idec Pharma Corp | Administração intratecal de rituximab para tratamento de linfomas do sistema nervoso central |
| AU2001257206B2 (en) | 2000-04-26 | 2006-10-05 | Elusys Therapeutics, Inc. | Bispecific molecules and uses thereof |
| US7560534B2 (en) | 2000-05-08 | 2009-07-14 | Celldex Research Corporation | Molecular conjugates comprising human monoclonal antibodies to dendritic cells |
| AU6138301A (en) | 2000-05-08 | 2001-11-20 | Medarex Inc | Human monoclonal antibodies to dendritic cells |
| WO2001090192A2 (en) | 2000-05-24 | 2001-11-29 | Imclone Systems Incorporated | Bispecific immunoglobulin-like antigen binding proteins and method of production |
| JP2004512262A (ja) | 2000-06-20 | 2004-04-22 | ăąă€ăăăŻăăăĄăŒăăčăŒăăŁă«ă«ășăăłăŒăăŹă€ă·ă§ăł | éæŸć°æ§æïœïœïŒïŒæäœïŒæŸć°æšèæïœïœïŒïŒæäœăźç”ćă |
| CA2410371C (en) | 2000-06-22 | 2015-11-17 | University Of Iowa Research Foundation | Methods for enhancing antibody-induced cell lysis and treating cancer |
| JP4955185B2 (ja) | 2000-06-29 | 2012-06-20 | ăąăăăă»ă©ăă©ăăȘăŒăș | äșéçčç°æ§æäœăȘăăłă«äœèŁœæčæłăăăłäœżçšæčæł |
| AU6461201A (en) | 2000-07-12 | 2002-01-21 | Idec Pharma Corp | Treatment of b cell malignancies using combination of b cell depleting antibody and immune modulating antibody related applications |
| IL152940A0 (en) | 2000-07-19 | 2003-06-24 | Orbotech Ltd | Apparatus and method for electrical testing of electrical circuits |
| US20020025317A1 (en) | 2000-07-20 | 2002-02-28 | Schering Ag | Bispecific monoclonal antibodies to IL-12 and IL-18 |
| AU2001282861A1 (en) | 2000-07-24 | 2002-02-05 | Florida State University Research Foundation | Method and apparatus for removal of minute particles from a surface using thermophoresis to prevent particle redeposition |
| EP1307490B1 (de) | 2000-08-11 | 2007-04-18 | Ruprecht-Karls-UniversitÀt Heidelberg | Fv-konstrukte mit beeinflussbarer affinitat zu einer zu bindenden substanz |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| US20020128448A1 (en) | 2000-10-20 | 2002-09-12 | Idec Pharmaceuticals Corporation | Variant IgG3 Rituxan and therapeutic use thereof |
| US7754208B2 (en) * | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| EP2316951A1 (en) | 2001-01-17 | 2011-05-04 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| PL372140A1 (en) | 2001-01-29 | 2005-07-11 | Idec Pharmaceuticals Corporation | Modified antibodies and methods of use |
| US7319139B2 (en) | 2001-01-29 | 2008-01-15 | Biogen Idec, Inc. | TAG-72 specific CH2 domain deleted antibodies |
| AU2002243718B2 (en) | 2001-01-31 | 2007-12-06 | Biogen Idec Inc. | Use of immunoregulatory antibodies in the treatment of neoplastic disorders |
| EP1370588A2 (en) | 2001-02-12 | 2003-12-17 | Medarex, Inc. | Human monoclonal antibodies to fc alpha receptor (cd89) |
| RU2003129528A (ru) * | 2001-03-07 | 2005-04-10 | ĐĐ”ŃĐș ĐĐ°ŃĐ”ĐœŃ ĐĐŒĐ±Đ„ (DE) | ĐĄĐżĐŸŃĐŸĐ± ŃĐșŃĐżŃĐ”ŃŃОО бДлĐșĐŸĐČ, ŃĐŸĐŽĐ”ŃжаŃĐžŃ ĐČ ĐșĐ°ŃĐ”ŃŃĐČĐ” ĐșĐŸĐŒĐżĐŸĐœĐ”ĐœŃĐ° гОбŃĐžĐŽĐœŃĐč ĐžĐ·ĐŸŃОп Đ°ĐœŃĐžŃДла |
| WO2002072141A2 (en) | 2001-03-09 | 2002-09-19 | William Herman | Targeted ligands |
| JP2005500018A (ja) | 2001-04-02 | 2005-01-06 | ăąă€ăă㯠ăăĄăŒăăčăŒăăŁă«ă«ăș ăłăŒăăŹă€ă·ă§ăł | ïœïŒŽïŒ©ïŒ©ïŒ©ăšćæçșçŸăăç”æăæäœ |
| ES2364816T3 (es) | 2001-04-02 | 2011-09-14 | Genentech, Inc. | Terapia de combinaciĂłn. |
| US20040058445A1 (en) * | 2001-04-26 | 2004-03-25 | Ledbetter Jeffrey Alan | Activation of tumor-reactive lymphocytes via antibodies or genes recognizing CD3 or 4-1BB |
| UA78706C2 (en) | 2001-06-01 | 2007-04-25 | Wyeth Corp | Combination of rapamycin derivative and antitumor alkylating agent and method for treating soft tissue sarcoma and colonic cancer |
| BRPI0210405B8 (pt) | 2001-06-13 | 2021-05-25 | Genmab As | anticorpo monoclonal humano, molĂ©cula biespecĂfica, mĂ©todo in vitro para inibir o crescimento de uma cĂ©lula expressando egfr, para induzir a citĂłlise de uma cĂ©lula expressando egfr, e para detectar a presença de antĂgeno egfr ou uma cĂ©lula expressando egfr em uma amostra, e, vetor de expressĂŁo |
| AU2002315168A1 (en) | 2001-06-14 | 2003-01-02 | Intermune, Inc. | Combination therapy of gamma-interferon and b cell specific antibodies |
| US20020196854A1 (en) | 2001-06-15 | 2002-12-26 | Jongil Kim | Fast video encoder using adaptive hierarchical video processing in a down-sampled domain |
| US6881557B2 (en) * | 2001-07-12 | 2005-04-19 | Arrowsmith Technologies Llp | Super humanized antibodies |
| US20030026780A1 (en) | 2001-07-18 | 2003-02-06 | Hood Leroy E. | Innate immunity mediated methods of treating pathological conditions |
| US20030064053A1 (en) | 2001-08-31 | 2003-04-03 | Shengjiang Liu | Multivalent protein conjugate with multiple ligand-binding domains of receptors |
| DE60124912T2 (de) | 2001-09-14 | 2007-06-14 | Affimed Therapeutics Ag | Multimerische, einzelkettige, Tandem-Fv-Antikörper |
| EP1448584B1 (en) * | 2001-09-26 | 2010-05-19 | The Government of the United States of America as represented by The Secretary of Health and Human Services | Mutated anti-cd22 antibodies with increased affinity to cd22-expressing leukemia cells |
| WO2003026490A2 (en) | 2001-09-28 | 2003-04-03 | Elusys Therapeutics, Inc. | Methods and compositions for prevention, diagnosis, and treatment of cancer using bispecific molecules |
| ATE423571T1 (de) | 2001-10-12 | 2009-03-15 | Schering Corp | Verwendung von bispezifischen antikörpern gegen einen aktivierenden rezeptor fcepsilonri und gegen einen inhibierenden rezeptor ox2ra (cd200ra) zur regulierung der immunantworten |
| DE10156482A1 (de) | 2001-11-12 | 2003-05-28 | Gundram Jung | Bispezifisches Antikörper-MolekĂŒl |
| DE60127143T2 (de) | 2001-11-14 | 2007-11-15 | Affimed Therapeutics Ag | Bispezifische Antikörper gegen CD19 und CD16 und deren Verwendung |
| IL162732A0 (en) | 2001-12-26 | 2005-11-20 | Immunomedics Inc | Methods of generating multispecific, multivalent agents from hv and vl domains |
| EP2295468B1 (en) | 2002-02-14 | 2015-07-08 | Immunomedics, Inc. | Anti-CD20 antibodies and fusion proteins thereof and methods of use |
| AU2003209446B2 (en) | 2002-03-01 | 2008-09-25 | Immunomedics, Inc. | Bispecific antibody point mutations for enhancing rate of clearance |
| US8361464B2 (en) | 2002-03-01 | 2013-01-29 | Immunomedics, Inc. | Anthracycline-Antibody Conjugates for Cancer Therapy |
| US20030219436A1 (en) | 2002-03-15 | 2003-11-27 | Ledbetter Jeffrey A. | Compositions and methods to regulate an immune response using CD83 gene expressed in tumors and using soluble CD83-Ig fusion protein |
| US7332585B2 (en) | 2002-04-05 | 2008-02-19 | The Regents Of The California University | Bispecific single chain Fv antibody molecules and methods of use thereof |
| US7332580B2 (en) | 2002-04-05 | 2008-02-19 | The Regents Of The University Of California | Bispecific single chain Fv antibody molecules and methods of use thereof |
| CA2379586A1 (en) | 2002-04-10 | 2003-10-10 | William Herman | Fluid targeted ligands |
| EP1505148B1 (en) | 2002-04-26 | 2009-04-15 | Chugai Seiyaku Kabushiki Kaisha | Methods of screening for agonistic antibodies |
| US7026330B2 (en) | 2002-05-30 | 2006-04-11 | The Children's Hospital Of Philadelphia | Methods for treatment of acute lymphocytic leukemia |
| US8034904B2 (en) | 2002-06-14 | 2011-10-11 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| AU2003244817B2 (en) | 2002-06-28 | 2010-08-26 | Domantis Limited | Antigen-binding immunoglobulin single variable domains and dual-specific constructs |
| DK1534335T4 (en) | 2002-08-14 | 2015-10-05 | Macrogenics Inc | FCGAMMARIIB-SPECIFIC ANTIBODIES AND PROCEDURES FOR USE THEREOF |
| JP4790413B2 (ja) | 2002-10-08 | 2011-10-12 | ă€ăă„ăŒăăĄăăŁăŻăčăă€ăłăłăŒăăŹă€ăăă | æäœçæł |
| MXPA05003796A (es) | 2002-10-10 | 2006-02-22 | Merck Patent Gmbh | Anticuerpos anti-erb-b biespecificos y su uso en terapia de tumor. |
| DK1551876T3 (da) | 2002-10-16 | 2011-06-14 | Purdue Pharma Lp | Antistoffer, der binder til celle-associerede ca 125/0722P og fremgangsmÄder til anvendelse deraf |
| KR100932340B1 (ko) | 2002-10-17 | 2009-12-16 | ì 맔 ììŽ/ìì€ | ïŒŁïœ20ì ëí ìžê° ëȘšë žíŽëĄë íìČŽ |
| CN103833854B (zh) | 2002-12-16 | 2017-12-12 | ć„æł°ç§çç©ææŻć Źćž | ć ç«çèçœćäœćć ¶çšé |
| CN100473664C (zh) | 2002-12-20 | 2009-04-01 | æć„„æ čIdecé©ŹèšèŻžćĄć Źćž | ć€ä»·æ·ć·ŽæŻçŽ ÎČćäœæżćšććć ¶æČ»ççšé |
| JP4898120B2 (ja) | 2002-12-20 | 2012-03-14 | ăąăăă ăă€ăȘă»ă©ăă„ăŒăăŁăŻăč ăłăŒăăŹă€ă·ă§ăł | ïœïœïŒïŒă«ćŻŸăăæäœăšăăźć©çšæł |
| ES2354610T5 (es) * | 2002-12-23 | 2020-09-14 | Bristol Myers Squibb Co | Mejora de la calidad del producto en procedimientos de cultivo de cĂ©lulas de mamĂfero para la producciĂłn de proteĂna |
| CA2414148A1 (en) | 2002-12-30 | 2004-06-30 | William Herman | Targeted ligands |
| US20050008625A1 (en) | 2003-02-13 | 2005-01-13 | Kalobios, Inc. | Antibody affinity engineering by serial epitope-guided complementarity replacement |
| JP3803790B2 (ja) | 2003-02-17 | 2006-08-02 | æ ȘćŒäŒç€Ÿæ±ćăăŻăăąăŒă | æ°èŠăȘăă€ăąăăăŁćäșéçčç°æ§æäœ |
| PT1599504E (pt) | 2003-02-25 | 2015-03-02 | Vaccibody As | Anticorpo modificado |
| AR044388A1 (es) | 2003-05-20 | 2005-09-07 | Applied Molecular Evolution | Moleculas de union a cd20 |
| US20050008649A1 (en) | 2003-06-02 | 2005-01-13 | University Of Miami | Chimeric molecules and methods of use |
| CN1279056C (zh) | 2003-06-06 | 2006-10-11 | é©Źè | èżç€çžć łæćsm5ïŒ1ççčćŒæ§æäœćć ¶ćșçš |
| CA2529945A1 (en) | 2003-06-27 | 2005-01-06 | Biogen Idec Ma Inc. | Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions |
| EP1638510B1 (en) | 2003-07-01 | 2015-09-02 | Immunomedics, Inc. | Multivalent carriers of bi-specific antibodies |
| US6864837B2 (en) | 2003-07-18 | 2005-03-08 | Ems Technologies, Inc. | Vertical electrical downtilt antenna |
| US7754209B2 (en) * | 2003-07-26 | 2010-07-13 | Trubion Pharmaceuticals | Binding constructs and methods for use thereof |
| WO2005018671A1 (ja) | 2003-08-21 | 2005-03-03 | Kyowa Hakko Kogyo Co., Ltd. | çè»ąç§»é»ćźłć€ |
| KR20120125634A (ko) | 2003-10-16 | 2012-11-16 | ë§ìŽíŹëĄë©íž ììŽì§ | ë€ì€íčìŽì íë©Žìíë ïœïœ3-ë°ìžë |
| JP4762904B2 (ja) | 2003-11-13 | 2011-08-31 | ăăłă ăăŒă«ăăŁăłă°ăč ă«ăłăăăŒ ăȘăăăă | ć ç«ă°ăăăȘăłäžć€é ćăźéçŁæčæł |
| CN1922210A (zh) | 2003-12-19 | 2007-02-28 | ć„æł°ç§çç©ææŻć Źćž | ćŻçšäœæČ»çćçćä»·æäœçæź” |
| US20070167478A1 (en) | 2003-12-22 | 2007-07-19 | Anne Boulay | Biomarkers for sensitivity of proliferative diseases to mtor inhibitors |
| US7235641B2 (en) | 2003-12-22 | 2007-06-26 | Micromet Ag | Bispecific antibodies |
| WO2005077981A2 (en) | 2003-12-22 | 2005-08-25 | Xencor, Inc. | Fc POLYPEPTIDES WITH NOVEL Fc LIGAND BINDING SITES |
| AU2005206536B2 (en) | 2004-01-16 | 2010-09-02 | Regeneron Pharmaceuticals, Inc. | Fusion polypeptides capable of activating receptors |
| KR20060131892A (ko) | 2004-02-16 | 2006-12-20 | ë§ìŽíŹëĄë©íž ììŽì§ | ë ë©Žììì±ìž êČ°í© ë¶ì |
| AR047988A1 (es) | 2004-03-11 | 2006-03-15 | Wyeth Corp | Combinaciones antineoplĂĄsicas de cci-779 y rituximab |
| ATE531732T1 (de) | 2004-03-30 | 2011-11-15 | Yissum Res Dev Co | Bi-spezifische antikörper, die auf an reaktionen vom allergischen typ beteiligte zellen zielen, zusammensetzungen und anwendungen davon |
| EP1740946B1 (en) | 2004-04-20 | 2013-11-06 | Genmab A/S | Human monoclonal antibodies against cd20 |
| EP1765870A2 (en) | 2004-06-03 | 2007-03-28 | Medarex, Inc. | Human monoclonal antibodies to fc gamma receptor i (cd64) |
| DOP2005000108A (es) | 2004-06-04 | 2007-06-15 | Genentech Inc | Method for treating lupus |
| TW201422238A (zh) | 2004-06-04 | 2014-06-16 | Genentech Inc | ïŒŁïœïŒïŒæé«æŒæČ»çć€çŒæ§çĄŹćçäčçšéćçšæŒè©Čçšéäčç©ć |
| US20060008415A1 (en) | 2004-06-25 | 2006-01-12 | Protein Design Labs, Inc. | Stable liquid and lyophilized formulation of proteins |
| EP1786918A4 (en) | 2004-07-17 | 2009-02-11 | Imclone Systems Inc | NEW BISPECIFIC ANTIBODY TETRAVALENT |
| CA2580336C (en) | 2004-07-22 | 2016-07-19 | Roger Kingdon Craig | Vh heavy chain only antibodies, and vh heavy chain only dimer compounds and uses thereof |
| CA2578613A1 (en) | 2004-08-11 | 2007-01-25 | Trubion Pharmaceuticals, Inc. | Binding domain fusion proteins |
| AU2005282700A1 (en) | 2004-09-02 | 2006-03-16 | Genentech, Inc. | Heteromultimeric molecules |
| US7393662B2 (en) | 2004-09-03 | 2008-07-01 | Centocor, Inc. | Human EPO mimetic hinge core mimetibodies, compositions, methods and uses |
| CA2580271A1 (en) | 2004-10-05 | 2006-04-20 | Genentech, Inc. | Method for treating vasculitis |
| EP1666500B1 (en) | 2004-12-01 | 2011-09-21 | Trion Pharma Gmbh | Use of trifunctionel antibodies to reduce the risk for GvHD in allogeneic antitumor cell therapy |
| JP2008523083A (ja) | 2004-12-08 | 2008-07-03 | ă€ă ăăĄăăŁăŻăčïŒ ă€ăłăłăŒăăŹă€ăăă | ççæ§çŸæŁăăăłć ç«èȘżçŻäžć šçŸæŁăæææ§çŸæŁăç çèĄçźĄæ°çăăăłăăăźć ç«çæłăăăłæ€ćșăźăăăźæčæłăăăłç”æç© |
| FR2879204B1 (fr) | 2004-12-15 | 2007-02-16 | Lab Francais Du Fractionnement | Anticorps cytotoxique dirige contre les proliferations hematopoietiques lymphoides de type b. |
| WO2006074399A2 (en) | 2005-01-05 | 2006-07-13 | Biogen Idec Ma Inc. | Multispecific binding molecules comprising connecting peptides |
| US8436190B2 (en) | 2005-01-14 | 2013-05-07 | Cephalon, Inc. | Bendamustine pharmaceutical compositions |
| KR100616666B1 (ko) | 2005-01-27 | 2006-08-28 | ìŒì±ì êž°ìŁŒìíìŹ | ìčŽëłžëë žíëžì ê”Źìëëêž°ë„Œ íì±íë ë°©ëČ,ê”Źìëëêž°ê° íì±ë ìčŽëłžëë žíëžë„Œ êž°íì ë¶ì°©íëë°©ëČ ë° ìŽì ë°ëŒ ì ìĄ°ë ìčŽëłžëë žíëž ë° êž°í |
| DOP2006000029A (es) | 2005-02-07 | 2006-08-15 | Genentech Inc | Antibody variants and uses thereof. (variantes de un anticuerpo y usos de las mismas) |
| EP3050963B1 (en) | 2005-03-31 | 2019-09-18 | Chugai Seiyaku Kabushiki Kaisha | Process for production of polypeptide by regulation of assembly |
| AR053579A1 (es) | 2005-04-15 | 2007-05-09 | Genentech Inc | Tratamiento de la enfermedad inflamatoria intestinal (eii) |
| WO2006117782A2 (en) | 2005-05-04 | 2006-11-09 | Quark Pharmaceuticals, Inc. | Recombinant antibodies against cd55 and cd59 and uses thereof |
| US20060263367A1 (en) | 2005-05-23 | 2006-11-23 | Fey Georg H | Bispecific antibody devoid of Fc region and method of treatment using same |
| BRPI0611220A2 (pt) | 2005-06-02 | 2010-08-24 | Astrazeneca Ab | anticorpos direcionados para cd20 e usos dos mesmos |
| WO2007014238A2 (en) | 2005-07-25 | 2007-02-01 | Trubion Pharmaceuticals, Inc. | Single dose use of cd20-specific binding molecules |
| SI1912675T1 (sl) | 2005-07-25 | 2014-07-31 | Emergent Product Development Seattle, Llc | zmanjĆĄanje ĆĄtevila celic B z uporabo molekul, ki se specifiÄno veĆŸejo na CD37 in CD20 |
| US20080279850A1 (en) | 2005-07-25 | 2008-11-13 | Trubion Pharmaceuticals, Inc. | B-Cell Reduction Using CD37-Specific and CD20-Specific Binding Molecules |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| JP4641476B2 (ja) | 2005-09-15 | 2011-03-02 | ăă€ăăłæ ȘćŒäŒç€Ÿ | ăăăŒăăąăŹă€ăźèŁœé èŁ çœź |
| EP1979378B1 (en) * | 2005-12-20 | 2012-07-25 | MorphoSys AG | Novel collection of hcdr3 regions and uses therefor |
| JP2009526857A (ja) | 2006-02-15 | 2009-07-23 | ă€ă ăŻăăŒăłă»ăȘăăăăă»ă©ă€ăąăăȘăăŁă»ă«ăłăăăŒ | æ©èœæ§æäœ |
| EP2418223A3 (en) * | 2006-06-12 | 2013-01-16 | Emergent Product Development Seattle, LLC | Single-chain multivalent binding proteins with effector function |
| CN101646688A (zh) | 2006-10-24 | 2010-02-10 | çčéČæŻæèŻćć Źćž | ć©çšæ çČŸèșæé«æäœäŸè”æ§ç»èæŻæ§çæčæł |
| US7846434B2 (en) | 2006-10-24 | 2010-12-07 | Trubion Pharmaceuticals, Inc. | Materials and methods for improved immunoglycoproteins |
| JP2010527325A (ja) | 2007-04-02 | 2010-08-12 | ăžă§ăăłăăăŻïŒ ă€ăłăłăŒăăŹă€ăăă | ïŒąçŽ°èăąăłăżăŽăăčăă«ćżçăăéąçŻăȘăŠăăăäșæžŹăăăă€ăȘăăŒă«ăŒ |
| WO2008153636A1 (en) | 2007-05-04 | 2008-12-18 | Cellsignaling Technology, Inc. | Phospho-specific antibodies to p13k regulatory subunit and uses thereof |
| MX2009012066A (es) | 2007-05-09 | 2009-11-19 | Novartis Ag | Imidazopirinas sustituidas como inhibidoras de cinasa de lipido p13k. |
| CN101802197A (zh) | 2007-05-14 | 2010-08-11 | æŻć„„æ čèŸèżȘć Mać Źćž | ćéŸFCïŒScFcïŒćșăć ć«ć ¶çç»ćć€èœćäžć ¶çžć łçæčæł |
| WO2008152387A1 (en) | 2007-06-12 | 2008-12-18 | F.Hoffmann-La Roche Ag | Quinazoline derivatives as pi3 kinase inhibitors |
| WO2008152394A1 (en) | 2007-06-12 | 2008-12-18 | F.Hoffmann-La Roche Ag | Pharmaceutical compounds |
| JP5539190B2 (ja) | 2007-06-12 | 2014-07-02 | ăšăïŒăăăăłâă© ăă·ă„ ăąăŒăČăŒ | ăăąăŸăăăȘăăžăłéĄćăłăăčăăĄăăžă«ă€ăă·ăăŒă«âïŒăăăŒăŒăźă€ăłăăăżăŒăšăăŠăźăăăăźäœżçš |
| EP2167130A2 (en) * | 2007-07-06 | 2010-03-31 | Trubion Pharmaceuticals, Inc. | Binding peptides having a c-terminally disposed specific binding domain |
| PE20140196A1 (es) | 2007-08-09 | 2014-03-19 | Boehringer Ingelheim Int | Anticuerpos anti-cd37 |
| CA2699202C (en) | 2007-09-12 | 2016-09-27 | F. Hoffmann-La Roche Ag | Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use |
| EP2217590A4 (en) | 2007-09-17 | 2011-12-14 | Glaxosmithkline Llc | Pyridopyrimidine derivatives as PI3-kinase inhibitors |
| CA2704711C (en) | 2007-09-24 | 2016-07-05 | Genentech, Inc. | Thiazolopyrimidine p13k inhibitor compounds and methods of use |
| PL2193133T3 (pl) | 2007-09-27 | 2016-01-29 | Fundacion Centro Nac De Investigaciones Oncologicas Carlos Iii | Imidazolotiadiazole do stosowania jako inhibitory kinazy biaĆkowej |
| GB2467670B (en) | 2007-10-04 | 2012-08-01 | Intellikine Inc | Chemical entities and therapeutic uses thereof |
| MY150993A (en) | 2007-10-05 | 2014-03-31 | Verastem Inc | Pyrimidine substituted purine derivatives |
| WO2009045174A1 (en) | 2007-10-05 | 2009-04-09 | S*Bio Pte Ltd | 2-morpholinylpurines as inhibitors of pi3k |
| AU2008312631A1 (en) | 2007-10-16 | 2009-04-23 | Wyeth Llc | Thienopyrimidine and pyrazolopyrimidine compounds and their use as mTOR kinase and PI3 kinase inhibitors |
| JP2011500823A (ja) | 2007-10-22 | 2011-01-06 | ă°ă©ăŻăœăčăăčăŻă©ă€ăłă»ăȘăăăăă»ă©ă€ăąăăȘăăŁă»ă«ăłăăăŒ | ïœïŒăăăŒăŒé»ćźłç©èłȘăšăăŠăźăăȘăăčă«ăăłăąăăèȘć°äœ |
| US20110230464A1 (en) | 2007-10-26 | 2011-09-22 | Paul Goldsmith | Purine derivatives useful as p13 kinase inhibitors |
| GB0721095D0 (en) | 2007-10-26 | 2007-12-05 | Piramed Ltd | Pharmaceutical compounds |
| WO2009059030A1 (en) | 2007-10-31 | 2009-05-07 | Burnham Institute For Medical Research | Pyrazole derivatives as kinase inhibitors |
| US20090131512A1 (en) | 2007-10-31 | 2009-05-21 | Dynavax Technologies Corp. | Inhibition of type I in IFN production |
| GEP20125635B (en) | 2007-11-13 | 2012-09-10 | Icos Corp | Inhibitors of human phosphatidyl-inositol 3-kinase delta |
| WO2009066084A1 (en) | 2007-11-21 | 2009-05-28 | F. Hoffmann-La Roche Ag | 2 -morpholinopyrimidines and their use as pi3 kinase inhibitors |
| WO2009070524A1 (en) | 2007-11-27 | 2009-06-04 | Wyeth | Pyrrolo[3,2-d]pyrimidine compounds and their use as pi3 kinase and mtor kinase inhibitors |
| EP2222674B8 (en) | 2007-11-27 | 2016-01-06 | Cellzome Limited | Amino triazoles as pi3k inhibitors |
| US8962803B2 (en) | 2008-02-29 | 2015-02-24 | AbbVie Deutschland GmbH & Co. KG | Antibodies against the RGM A protein and uses thereof |
| SG189772A1 (en) | 2008-04-11 | 2013-05-31 | Trubion Pharmaceuticals Inc | Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof |
| BRPI0921006A2 (pt) * | 2008-11-13 | 2015-12-15 | Emergent Product Dev Seattle | terapias imunoterapĂȘuticas combinadas de cd37 e usos destas |
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