ZA737247B
(en)
|
1972-09-29 |
1975-04-30 |
Ayerst Mckenna & Harrison |
Rapamycin and process of preparation
|
US3927193A
(en)
|
1973-05-18 |
1975-12-16 |
Hoffmann La Roche |
Localization of tumors by radiolabelled antibodies
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
JPS6023084B2
(ja)
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
US4444744A
(en)
|
1980-03-03 |
1984-04-24 |
Goldenberg Milton David |
Tumor localization and therapy with labeled antibodies to cell surface antigens
|
US4460559A
(en)
|
1980-03-03 |
1984-07-17 |
Goldenberg Milton David |
Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers
|
US4331647A
(en)
|
1980-03-03 |
1982-05-25 |
Goldenberg Milton David |
Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
|
US4361544A
(en)
|
1980-03-03 |
1982-11-30 |
Goldenberg Milton David |
Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers
|
US4348376A
(en)
|
1980-03-03 |
1982-09-07 |
Goldenberg Milton David |
Tumor localization and therapy with labeled anti-CEA antibody
|
US4460561A
(en)
|
1980-03-03 |
1984-07-17 |
Goldenberg M David |
Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers
|
US4316885A
(en)
|
1980-08-25 |
1982-02-23 |
Ayerst, Mckenna And Harrison, Inc. |
Acyl derivatives of rapamycin
|
US4468457A
(en)
|
1981-06-01 |
1984-08-28 |
David M. Goldenberg |
Method for producing a CSAp tryptic peptide and anti-CSAp antibodies
|
US4640835A
(en)
|
1981-10-30 |
1987-02-03 |
Nippon Chemiphar Company, Ltd. |
Plasminogen activator derivatives
|
US4769330A
(en)
|
1981-12-24 |
1988-09-06 |
Health Research, Incorporated |
Modified vaccinia virus and methods for making and using the same
|
US4818709A
(en)
|
1983-01-21 |
1989-04-04 |
Primus Frederick J |
CEA-family antigens, Anti-CEA antibodies and CEA immunoassay
|
US4460459A
(en)
|
1983-02-16 |
1984-07-17 |
Anschutz Mining Corporation |
Sequential flotation of sulfide ores
|
US4816567A
(en)
*
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
US4624846A
(en)
|
1983-07-29 |
1986-11-25 |
Immunomedics, Inc. |
Method for enhancing target specificity of antibody localization and clearance of non-target diagnostic and therapeutic principles
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
US4782840A
(en)
|
1984-03-02 |
1988-11-08 |
Neoprobe Corporation |
Method for locating, differentiating, and removing neoplasms
|
US4935495A
(en)
*
|
1984-12-21 |
1990-06-19 |
Oncogen |
Monoclonal antibodies to the L6 glycolipid antigenic determinant found on human non-small cell lung carcinomas
|
US4906562A
(en)
*
|
1984-12-21 |
1990-03-06 |
Oncogen |
Monocolonal antibodies and antigen for human non-small cell lung carcinomas
|
GB8508845D0
(en)
|
1985-04-04 |
1985-05-09 |
Hoffmann La Roche |
Vaccinia dna
|
EP0206448B1
(en)
|
1985-06-19 |
1990-11-14 |
Ajinomoto Co., Inc. |
Hemoglobin combined with a poly(alkylene oxide)
|
US5656266A
(en)
*
|
1985-11-19 |
1997-08-12 |
Schering Corporation |
Method of using interleukin-4
|
US4650803A
(en)
|
1985-12-06 |
1987-03-17 |
University Of Kansas |
Prodrugs of rapamycin
|
US5225539A
(en)
*
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
US4791192A
(en)
|
1986-06-26 |
1988-12-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified protein with polyethyleneglycol
|
US4704692A
(en)
|
1986-09-02 |
1987-11-03 |
Ladner Robert C |
Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
|
US5869620A
(en)
*
|
1986-09-02 |
1999-02-09 |
Enzon, Inc. |
Multivalent antigen-binding proteins
|
US5260203A
(en)
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
US4946778A
(en)
*
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
US5075109A
(en)
|
1986-10-24 |
1991-12-24 |
Southern Research Institute |
Method of potentiating an immune response
|
US6893625B1
(en)
*
|
1986-10-27 |
2005-05-17 |
Royalty Pharma Finance Trust |
Chimeric antibody with specificity to human B cell surface antigen
|
US4932412A
(en)
|
1986-12-18 |
1990-06-12 |
Immunomedics, Inc. |
Intraoperative and endoscopic tumor detection and therapy
|
IL85035A0
(en)
*
|
1987-01-08 |
1988-06-30 |
Int Genetic Eng |
Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
|
US5892019A
(en)
*
|
1987-07-15 |
1999-04-06 |
The United States Of America, As Represented By The Department Of Health And Human Services |
Production of a single-gene-encoded immunoglobulin
|
US4897268A
(en)
|
1987-08-03 |
1990-01-30 |
Southern Research Institute |
Drug delivery system and method of making the same
|
WO1989001973A2
(en)
|
1987-09-02 |
1989-03-09 |
Applied Biotechnology, Inc. |
Recombinant pox virus for immunization against tumor-associated antigens
|
US5677425A
(en)
|
1987-09-04 |
1997-10-14 |
Celltech Therapeutics Limited |
Recombinant antibody
|
GB8720833D0
(en)
|
1987-09-04 |
1987-10-14 |
Celltech Ltd |
Recombinant dna product
|
JP3095168B2
(ja)
|
1988-02-05 |
2000-10-03 |
エル. モリソン,シェリー |
ドメイン‐変性不変部を有する抗体
|
IL89220A
(en)
|
1988-02-11 |
1994-02-27 |
Bristol Myers Squibb Co |
Immunoconjugates of anthracycline, their production and pharmaceutical preparations containing them
|
US5506126A
(en)
|
1988-02-25 |
1996-04-09 |
The General Hospital Corporation |
Rapid immunoselection cloning method
|
HUT53672A
(en)
|
1988-02-25 |
1990-11-28 |
Gen Hospital Corp |
Quick immunoselective cloning process
|
US4861579A
(en)
|
1988-03-17 |
1989-08-29 |
American Cyanamid Company |
Suppression of B-lymphocytes in mammals by administration of anti-B-lymphocyte antibodies
|
US5601819A
(en)
|
1988-08-11 |
1997-02-11 |
The General Hospital Corporation |
Bispecific antibodies for selective immune regulation and for selective immune cell binding
|
US6352694B1
(en)
*
|
1994-06-03 |
2002-03-05 |
Genetics Institute, Inc. |
Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
|
CA2006408A1
(en)
|
1988-12-27 |
1990-06-27 |
Susumu Iwasa |
Bispecific monoclonal antibody, its production and use
|
US5217713A
(en)
|
1988-12-27 |
1993-06-08 |
Takeda Chemical Industries, Ltd. |
Cytotoxic bispecific monoclonal antibody, its production and use
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
EP0454781B1
(en)
|
1989-01-23 |
1998-12-16 |
Chiron Corporation |
Recombinant cells for therapies of infection and hyperproliferative disorders and preparation thereof
|
US5225538A
(en)
*
|
1989-02-23 |
1993-07-06 |
Genentech, Inc. |
Lymphocyte homing receptor/immunoglobulin fusion proteins
|
US5098833A
(en)
*
|
1989-02-23 |
1992-03-24 |
Genentech, Inc. |
DNA sequence encoding a functional domain of a lymphocyte homing receptor
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
WO1991000360A1
(en)
|
1989-06-29 |
1991-01-10 |
Medarex, Inc. |
Bispecific reagents for aids therapy
|
US5897861A
(en)
|
1989-06-29 |
1999-04-27 |
Medarex, Inc. |
Bispecific reagents for AIDS therapy
|
US5980896A
(en)
|
1989-06-30 |
1999-11-09 |
Bristol-Myers Squibb Company |
Antibodies reactive with human carcinomas
|
US6020145A
(en)
|
1989-06-30 |
2000-02-01 |
Bristol-Myers Squibb Company |
Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96
|
EP0845537A1
(en)
|
1989-08-18 |
1998-06-03 |
Chiron Corporation |
Recombinant retroviruses delivering vector constructs to target cells
|
US5605690A
(en)
*
|
1989-09-05 |
1997-02-25 |
Immunex Corporation |
Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor
|
EP0493418B1
(en)
|
1989-09-20 |
1997-04-23 |
Abbott Laboratories |
Method of producing fusion proteins
|
US6018031A
(en)
|
1989-10-20 |
2000-01-25 |
Trustees Of Dartmouth College |
Binding agents specific for IgA receptor
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
US5314995A
(en)
*
|
1990-01-22 |
1994-05-24 |
Oncogen |
Therapeutic interleukin-2-antibody based fusion proteins
|
ES2107454T3
(es)
|
1990-01-23 |
1997-12-01 |
Tanox Biosystems Inc |
Segmentos extracelulares de peptidos de anclaje de la inmunoglobulina ige humana, y anticuerpos especificos para los mismos.
|
EP0517754A1
(en)
|
1990-03-02 |
1992-12-16 |
Repligen Corporation |
Antibody constructs with enhanced binding affinity
|
US20030219446A1
(en)
|
1990-03-26 |
2003-11-27 |
Bristol-Myers Squibb Company |
Ligand for CD28 receptor on B cells and methods
|
US5580756A
(en)
|
1990-03-26 |
1996-12-03 |
Bristol-Myers Squibb Co. |
B7Ig fusion protein
|
GB9009106D0
(en)
|
1990-04-23 |
1990-06-20 |
3I Res Expl Ltd |
Processes and intermediates for synthetic antibody derivatives
|
WO1992000092A1
(en)
|
1990-07-02 |
1992-01-09 |
Bristol-Myers Squibb Company |
Ligand for cd28 receptor on b cells and methods
|
US5023264A
(en)
|
1990-07-16 |
1991-06-11 |
American Home Products Corporation |
Rapamycin oximes
|
US5023263A
(en)
|
1990-08-09 |
1991-06-11 |
American Home Products Corporation |
42-oxorapamycin
|
US5130307A
(en)
|
1990-09-28 |
1992-07-14 |
American Home Products Corporation |
Aminoesters of rapamycin
|
US5221670A
(en)
|
1990-09-19 |
1993-06-22 |
American Home Products Corporation |
Rapamycin esters
|
US5233036A
(en)
|
1990-10-16 |
1993-08-03 |
American Home Products Corporation |
Rapamycin alkoxyesters
|
AU8727291A
(en)
|
1990-10-29 |
1992-06-11 |
Cetus Oncology Corporation |
Bispecific antibodies, method of production, and uses thereof
|
US5709859A
(en)
*
|
1991-01-24 |
1998-01-20 |
Bristol-Myers Squibb Company |
Mixed specificity fusion proteins
|
WO1992017198A1
(en)
|
1991-03-28 |
1992-10-15 |
The Regents Of The University Of Minnesota |
Dna and amino acid sequence specific for natural killer cells
|
US5120842A
(en)
|
1991-04-01 |
1992-06-09 |
American Home Products Corporation |
Silyl ethers of rapamycin
|
US5100883A
(en)
|
1991-04-08 |
1992-03-31 |
American Home Products Corporation |
Fluorinated esters of rapamycin
|
US5118678A
(en)
|
1991-04-17 |
1992-06-02 |
American Home Products Corporation |
Carbamates of rapamycin
|
US5118677A
(en)
|
1991-05-20 |
1992-06-02 |
American Home Products Corporation |
Amide esters of rapamycin
|
EP0636173B1
(en)
|
1991-05-31 |
1998-09-02 |
Genentech, Inc. |
Treatment of hiv-associated immune thrombocytopenic purpura
|
DE4118120A1
(de)
|
1991-06-03 |
1992-12-10 |
Behringwerke Ag |
Tetravalente bispezifische rezeptoren, ihre herstellung und verwendung
|
US5770197A
(en)
*
|
1991-06-27 |
1998-06-23 |
Bristol-Myers Squibb Company |
Methods for regulating the immune response using B7 binding molecules and IL4-binding molecules
|
US5851795A
(en)
|
1991-06-27 |
1998-12-22 |
Bristol-Myers Squibb Company |
Soluble CTLA4 molecules and uses thereof
|
US6090914A
(en)
|
1991-06-27 |
2000-07-18 |
Bristol-Myers Squibb Company |
CTLA4/CD28Ig hybrid fusion proteins and uses thereof
|
US5637481A
(en)
*
|
1993-02-01 |
1997-06-10 |
Bristol-Myers Squibb Company |
Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
|
KR100238712B1
(ko)
*
|
1991-06-27 |
2000-01-15 |
스티븐 비. 데이비스 |
씨티엘에이4 수용체,그를 함유한 연합단백질 및 그의 용도
|
US5844095A
(en)
|
1991-06-27 |
1998-12-01 |
Bristol-Myers Squibb Company |
CTLA4 Ig fusion proteins
|
JPH06510036A
(ja)
|
1991-08-16 |
1994-11-10 |
バイカル・インコーポレイテッド |
嚢胞性線維症の治療のための組成物および方法
|
US5162333A
(en)
|
1991-09-11 |
1992-11-10 |
American Home Products Corporation |
Aminodiesters of rapamycin
|
US5962406A
(en)
*
|
1991-10-25 |
1999-10-05 |
Immunex Corporation |
Recombinant soluble CD40 ligand polypeptide and pharmaceutical composition containing the same
|
US5151413A
(en)
|
1991-11-06 |
1992-09-29 |
American Home Products Corporation |
Rapamycin acetals as immunosuppressant and antifungal agents
|
US6025165A
(en)
*
|
1991-11-25 |
2000-02-15 |
Enzon, Inc. |
Methods for producing multivalent antigen-binding proteins
|
DE69232137T2
(de)
|
1991-11-25 |
2002-05-29 |
Enzon Inc |
Multivalente antigen-bindende proteine
|
PT1024191E
(pt)
|
1991-12-02 |
2008-12-22 |
Medical Res Council |
Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
|
IL104684A0
(en)
|
1992-02-14 |
1993-06-10 |
Bristol Myers Squibb Co |
The cd40cr receptor and ligands therefor
|
US6472510B1
(en)
|
1992-02-14 |
2002-10-29 |
Bristol-Myers Squibb Company |
CD40 receptor ligands
|
US5177203A
(en)
|
1992-03-05 |
1993-01-05 |
American Home Products Corporation |
Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents
|
US6129914A
(en)
|
1992-03-27 |
2000-10-10 |
Protein Design Labs, Inc. |
Bispecific antibody effective to treat B-cell lymphoma and cell line
|
JPH07507689A
(ja)
|
1992-06-08 |
1995-08-31 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
特定組織のターゲティング方法及び組成物
|
WO1993025698A1
(en)
|
1992-06-10 |
1993-12-23 |
The United States Government As Represented By The |
Vector particles resistant to inactivation by human serum
|
GB2269175A
(en)
|
1992-07-31 |
1994-02-02 |
Imperial College |
Retroviral vectors
|
US5256790A
(en)
|
1992-08-13 |
1993-10-26 |
American Home Products Corporation |
27-hydroxyrapamycin and derivatives thereof
|
PT586002E
(pt)
|
1992-08-18 |
2000-07-31 |
Centro Inmunologia Molecular |
Anticorpos monoclonais que reconhecem o receptor do factor de crescimento epidermico, celulas e metodos para a sua producao e composicoes que os incluem
|
DK1589107T3
(da)
*
|
1992-08-21 |
2010-04-26 |
Univ Bruxelles |
Immonuglobuliner uden lette kæder
|
ZA936260B
(en)
|
1992-09-09 |
1994-03-18 |
Smithkline Beecham Corp |
Novel antibodies for conferring passive immunity against infection by a pathogen in man
|
US6066718A
(en)
|
1992-09-25 |
2000-05-23 |
Novartis Corporation |
Reshaped monoclonal antibodies against an immunoglobulin isotype
|
GB9221220D0
(en)
|
1992-10-09 |
1992-11-25 |
Sandoz Ag |
Organic componds
|
WO1994009034A1
(en)
|
1992-10-12 |
1994-04-28 |
Agen Limited |
Clot directed anticoagulant, process for making same and methods of use
|
US5480989A
(en)
|
1992-10-13 |
1996-01-02 |
American Home Products Corporation |
Carbamates of rapamycin
|
US5489680A
(en)
|
1992-10-13 |
1996-02-06 |
American Home Products Corporation |
Carbamates of rapamycin
|
US5411967A
(en)
|
1992-10-13 |
1995-05-02 |
American Home Products Corporation |
Carbamates of rapamycin
|
US5434260A
(en)
|
1992-10-13 |
1995-07-18 |
American Home Products Corporation |
Carbamates of rapamycin
|
US5302584A
(en)
|
1992-10-13 |
1994-04-12 |
American Home Products Corporation |
Carbamates of rapamycin
|
US5480988A
(en)
|
1992-10-13 |
1996-01-02 |
American Home Products Corporation |
Carbamates of rapamycin
|
US5262423A
(en)
|
1992-10-29 |
1993-11-16 |
American Home Products Corporation |
Rapamycin arylcarbonyl and alkoxycarbonyl carbamates as immunosuppressive and antifungal agents
|
US5258389A
(en)
|
1992-11-09 |
1993-11-02 |
Merck & Co., Inc. |
O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
|
US5736137A
(en)
*
|
1992-11-13 |
1998-04-07 |
Idec Pharmaceuticals Corporation |
Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
|
PT752248E
(pt)
|
1992-11-13 |
2001-01-31 |
Idec Pharma Corp |
Aplicacao terapeutica de anticorpos quimericos e marcados radioactivamente contra antigenios de diferenciacao restrita de linfocitos b humanos para o tratamento do linfoma de celulas b
|
US5260300A
(en)
|
1992-11-19 |
1993-11-09 |
American Home Products Corporation |
Rapamycin carbonate esters as immuno-suppressant agents
|
GB9225453D0
(en)
|
1992-12-04 |
1993-01-27 |
Medical Res Council |
Binding proteins
|
JP3720353B2
(ja)
|
1992-12-04 |
2005-11-24 |
メディカル リサーチ カウンシル |
多価および多重特異性の結合タンパク質、それらの製造および使用
|
US5773253A
(en)
|
1993-01-22 |
1998-06-30 |
Bristol-Myers Squibb Company |
MYPPPY variants of CTL A4 and uses thereof
|
US6482919B2
(en)
|
1993-02-01 |
2002-11-19 |
Bristol-Myers Squibb Company |
Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
|
US5597707A
(en)
*
|
1993-04-15 |
1997-01-28 |
Bristol-Myers Squibb Company |
Tumor associated antigen recognized by the murine monoclonal antibody L6, its oligonucleotide sequence and methods for their use
|
US5504091A
(en)
|
1993-04-23 |
1996-04-02 |
American Home Products Corporation |
Biotin esters of rapamycin
|
AU6796094A
(en)
|
1993-04-29 |
1994-11-21 |
Raymond Hamers |
Production of antibodies or (functionalized) fragments thereof derived from heavy chain immunoglobulins of (camelidae)
|
US5795572A
(en)
*
|
1993-05-25 |
1998-08-18 |
Bristol-Myers Squibb Company |
Monoclonal antibodies and FV specific for CD2 antigen
|
US5747654A
(en)
|
1993-06-14 |
1998-05-05 |
The United States Of America As Represented By The Department Of Health And Human Services |
Recombinant disulfide-stabilized polypeptide fragments having binding specificity
|
US6476198B1
(en)
|
1993-07-13 |
2002-11-05 |
The Scripps Research Institute |
Multispecific and multivalent antigen-binding polypeptide molecules
|
US5417972A
(en)
|
1993-08-02 |
1995-05-23 |
The Board Of Trustees Of The Leland Stanford Junior University |
Method of killing B-cells in a complement independent and an ADCC independent manner using antibodies which specifically bind CDIM
|
US5869049A
(en)
*
|
1993-09-02 |
1999-02-09 |
Trustees Of Dartmouth College |
Methods of inducing T cell unresponsiveness to bone marrow with gp39 antagonists
|
ATE188487T1
(de)
|
1993-09-02 |
2000-01-15 |
Dartmouth College |
Anti-gp39 antikoerper und deren verwendungen
|
US5595721A
(en)
|
1993-09-16 |
1997-01-21 |
Coulter Pharmaceutical, Inc. |
Radioimmunotherapy of lymphoma using anti-CD20
|
GB9412166D0
(en)
|
1993-09-22 |
1994-08-10 |
Medical Res Council |
Retargetting antibodies
|
ATE173740T1
(de)
|
1993-09-22 |
1998-12-15 |
Medical Res Council |
Antikoerper mit geaenderter zielrichtung
|
WO1995009917A1
(en)
|
1993-10-07 |
1995-04-13 |
The Regents Of The University Of California |
Genetically engineered bispecific tetravalent antibodies
|
US5373014A
(en)
|
1993-10-08 |
1994-12-13 |
American Home Products Corporation |
Rapamycin oximes
|
US5391730A
(en)
|
1993-10-08 |
1995-02-21 |
American Home Products Corporation |
Phosphorylcarbamates of rapamycin and oxime derivatives thereof
|
US5385910A
(en)
|
1993-11-22 |
1995-01-31 |
American Home Products Corporation |
Gem-distributed esters of rapamycin
|
US5385909A
(en)
|
1993-11-22 |
1995-01-31 |
American Home Products Corporation |
Heterocyclic esters of rapamycin
|
US5385908A
(en)
|
1993-11-22 |
1995-01-31 |
American Home Products Corporation |
Hindered esters of rapamycin
|
BR9408323A
(pt)
|
1993-12-17 |
1997-08-19 |
Sandoz Ag |
Derivados de rapamicina
|
US5389639A
(en)
|
1993-12-29 |
1995-02-14 |
American Home Products Company |
Amino alkanoic esters of rapamycin
|
US6380369B1
(en)
|
1994-01-27 |
2002-04-30 |
Human Genome Sciences, Inc. |
Human DNA mismatch repair proteins
|
WO1995021258A1
(en)
*
|
1994-02-01 |
1995-08-10 |
United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Fusion proteins that include antibody and nonantibody portions
|
CA2183268C
(en)
|
1994-03-07 |
2001-05-15 |
Edward D. Ball |
Bispecific molecules having clinical utilities
|
RU2170257C2
(ru)
|
1994-03-17 |
2001-07-10 |
Мерк Патент Гмбх |
Анти-эфрр одноцепочечный fv, химерное анти-эфрр антитело и способ его получения, фармацевтическая композиция для лечения опухолей, средство для диагностики локализации или оценки роста опухоли
|
US5362718A
(en)
|
1994-04-18 |
1994-11-08 |
American Home Products Corporation |
Rapamycin hydroxyesters
|
ATE228166T1
(de)
|
1994-05-02 |
2002-12-15 |
Bernd Groner |
Bifunktionelles protein, herstellung und verwendung
|
US5945273A
(en)
|
1997-06-03 |
1999-08-31 |
Human Genome Sciences, Inc. |
Human oxalyl-coa decarboxylase
|
US5463048A
(en)
|
1994-06-14 |
1995-10-31 |
American Home Products Corporation |
Rapamycin amidino carbamates
|
US5888773A
(en)
|
1994-08-17 |
1999-03-30 |
The United States Of America As Represented By The Department Of Health And Human Services |
Method of producing single-chain Fv molecules
|
EP0807183B1
(de)
|
1994-08-26 |
2001-01-03 |
Aventis Pharma Deutschland GmbH |
Gentherapie von erkrankungen, die durch das immunsystem bedingt sind, mit hilfe eines zellspezifischen zellzyklusregulierten wirkstoffes
|
US6380169B1
(en)
|
1994-08-31 |
2002-04-30 |
Isis Pharmaceuticals, Inc. |
Metal complex containing oligonucleoside cleavage compounds and therapies
|
US5736524A
(en)
|
1994-11-14 |
1998-04-07 |
Merck & Co.,. Inc. |
Polynucleotide tuberculosis vaccine
|
US5491231A
(en)
|
1994-11-28 |
1996-02-13 |
American Home Products Corporation |
Hindered N-oxide esters of rapamycin
|
US5563145A
(en)
|
1994-12-07 |
1996-10-08 |
American Home Products Corporation |
Rapamycin 42-oximes and hydroxylamines
|
US6383814B1
(en)
|
1994-12-09 |
2002-05-07 |
Genzyme Corporation |
Cationic amphiphiles for intracellular delivery of therapeutic molecules
|
US5876950A
(en)
*
|
1995-01-26 |
1999-03-02 |
Bristol-Myers Squibb Company |
Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy
|
EP0739981A1
(en)
|
1995-04-25 |
1996-10-30 |
Vrije Universiteit Brussel |
Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes
|
US6410690B1
(en)
|
1995-06-07 |
2002-06-25 |
Medarex, Inc. |
Therapeutic compounds comprised of anti-Fc receptor antibodies
|
US5985890A
(en)
|
1995-06-09 |
1999-11-16 |
Novartis Ag |
Rapamycin derivatives
|
GB9518220D0
(en)
|
1995-09-06 |
1995-11-08 |
Medical Res Council |
Checkpoint gene
|
US5866330A
(en)
|
1995-09-12 |
1999-02-02 |
The Johns Hopkins University School Of Medicine |
Method for serial analysis of gene expression
|
JPH11513669A
(ja)
*
|
1995-10-13 |
1999-11-24 |
アメリカ合衆国 |
ジスルフィド安定化抗体フラグメントを含む免疫毒素
|
US6440418B1
(en)
|
1995-11-07 |
2002-08-27 |
Idec Pharmaceuticals Corporation |
Methods of treating autoimmune diseases with gp39-specific antibodies
|
US6379966B2
(en)
|
1999-02-26 |
2002-04-30 |
Mirus Corporation |
Intravascular delivery of non-viral nucleic acid
|
US5780462A
(en)
|
1995-12-27 |
1998-07-14 |
American Home Products Corporation |
Water soluble rapamycin esters
|
US6750334B1
(en)
|
1996-02-02 |
2004-06-15 |
Repligen Corporation |
CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor
|
GB2310894A
(en)
|
1996-03-06 |
1997-09-10 |
Clive William Efford |
Multi-engine drive unit
|
EP1186300A1
(en)
|
1996-03-20 |
2002-03-13 |
Bristol-Myers Squibb Company |
Pharmaceutical compositions useful for inhibiting an immune response by blocking the GP39/CD40 and CTLA4/CD28/B7 pathways
|
US5916560A
(en)
*
|
1996-03-20 |
1999-06-29 |
Bristol-Myers Squibb Company |
Methods for inhibiting an immune response by blocking the GP39/CD40 and CTLA4/CD28/B7 pathways and compositions for use therewith
|
DE19613691A1
(de)
|
1996-04-05 |
1997-10-09 |
Boehringer Ingelheim Int |
Arzneimittel für die Behandlung von Tumorerkrankungen
|
US5922845A
(en)
|
1996-07-11 |
1999-07-13 |
Medarex, Inc. |
Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies
|
IL127891A0
(en)
*
|
1996-07-12 |
1999-10-28 |
Genentech Inc |
Chimeric heteromultimeter adhesins
|
EP0937082A2
(en)
|
1996-07-12 |
1999-08-25 |
Ariad Pharmaceuticals, Inc. |
Materials and method for treating or preventing pathogenic fungal infection
|
JP2000516452A
(ja)
|
1996-07-16 |
2000-12-12 |
プリュックテュン,アンドレアス |
可溶性が増大した免疫グロブリンスーパーファミリードメインおよびフラグメント
|
US5846948A
(en)
|
1996-08-30 |
1998-12-08 |
Arch Development Corporation |
Herpes simplex virus ORF P is a repressor of viral protein synthesis
|
GB9618477D0
(en)
|
1996-09-04 |
1996-10-16 |
Univ Leeds |
Gene therapy
|
US6368598B1
(en)
|
1996-09-16 |
2002-04-09 |
Jcrt Radiation Oncology Support Services, Inc. |
Drug complex for treatment of metastatic prostate cancer
|
US5972361A
(en)
|
1996-10-25 |
1999-10-26 |
The Procter & Gamble Company |
Cleansing products
|
US5858753A
(en)
|
1996-11-25 |
1999-01-12 |
Icos Corporation |
Lipid kinase
|
DE19651443A1
(de)
|
1996-12-11 |
1998-06-18 |
Hoechst Ag |
Selbstverstärkende, pharmakologisch kontrollierbare Expressionssysteme
|
KR19980066046A
(ko)
|
1997-01-18 |
1998-10-15 |
정용훈 |
고역가의 CTLA4-Ig 융합단백질
|
EP0860445A1
(en)
|
1997-02-18 |
1998-08-26 |
Hoechst Aktiengesellschaft |
New nucleotide sequences for the cell cycle regulated expression of structural genes
|
US6133426A
(en)
|
1997-02-21 |
2000-10-17 |
Genentech, Inc. |
Humanized anti-IL-8 monoclonal antibodies
|
JP2001500899A
(ja)
|
1997-03-11 |
2001-01-23 |
レ ラボラトワール エテルナ インコーポレイティド |
高い効能及び少ない副作用を供与する軟骨エキスと抗新形成剤との組合せを含んで成る抗腫瘍療法
|
US6384210B1
(en)
|
1997-03-20 |
2002-05-07 |
University Of Washington |
Solvent for biopolymer synthesis, solvent microdroplets and methods of use
|
US6306393B1
(en)
|
1997-03-24 |
2001-10-23 |
Immunomedics, Inc. |
Immunotherapy of B-cell malignancies using anti-CD22 antibodies
|
US6384203B1
(en)
|
1999-05-12 |
2002-05-07 |
Immunex Corporation |
Family of immunoregulators designated leukocyte immunoglobulin-like receptors (LIR)
|
US6217900B1
(en)
|
1997-04-30 |
2001-04-17 |
American Home Products Corporation |
Vesicular complexes and methods of making and using the same
|
US20020062010A1
(en)
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
US6171586B1
(en)
*
|
1997-06-13 |
2001-01-09 |
Genentech, Inc. |
Antibody formulation
|
JP3919235B2
(ja)
|
1997-06-13 |
2007-05-23 |
ジェネンテク,インコーポレイテッド |
抗体製剤
|
DE69830315T2
(de)
|
1997-06-24 |
2006-02-02 |
Genentech Inc., San Francisco |
Galactosylierte glykoproteine enthaltende zusammensetzungen und verfahren zur deren herstellung
|
US5994511A
(en)
|
1997-07-02 |
1999-11-30 |
Genentech, Inc. |
Anti-IgE antibodies and methods of improving polypeptides
|
US6368596B1
(en)
*
|
1997-07-08 |
2002-04-09 |
Board Of Regents, The University Of Texas System |
Compositions and methods for homoconjugates of antibodies which induce growth arrest or apoptosis of tumor cells
|
US6165476A
(en)
|
1997-07-10 |
2000-12-26 |
Beth Israel Deaconess Medical Center |
Fusion proteins with an immunoglobulin hinge region linker
|
US6342220B1
(en)
|
1997-08-25 |
2002-01-29 |
Genentech, Inc. |
Agonist antibodies
|
TW557297B
(en)
|
1997-09-26 |
2003-10-11 |
Abbott Lab |
Rapamycin analogs having immunomodulatory activity, and pharmaceutical compositions containing same
|
US6383746B1
(en)
|
1997-10-23 |
2002-05-07 |
The United States Of America As Represented By The Department Of Health And Human Services |
Functional promoter for CCR5
|
WO1999022764A1
(en)
|
1997-10-31 |
1999-05-14 |
Genentech, Inc. |
Methods and compositions comprising glycoprotein glycoforms
|
US6383811B2
(en)
|
1997-12-30 |
2002-05-07 |
Mirus Corporation |
Polyampholytes for delivering polyions to a cell
|
DE69922159T2
(de)
|
1998-01-23 |
2005-12-01 |
Vlaams Interuniversitair Instituut Voor Biotechnologie |
Mehrzweck-antikörperderivate
|
US6051228A
(en)
|
1998-02-19 |
2000-04-18 |
Bristol-Myers Squibb Co. |
Antibodies against human CD40
|
JP2003525016A
(ja)
|
1998-02-19 |
2003-08-26 |
エクサイト セラピーズ, インコーポレイテッド |
リンパ球活性化を調節するための組成物および方法
|
CN1204147C
(zh)
|
1998-02-25 |
2005-06-01 |
利思进药品公司 |
提高以抗体为基础的融合蛋白的循环半衰期的方法
|
US6383481B1
(en)
|
1998-03-30 |
2002-05-07 |
Japan Immunoresearch Laboratories Co., Ltd. |
Method for transplantation of hemopoietic stem cells
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
US6528624B1
(en)
|
1998-04-02 |
2003-03-04 |
Genentech, Inc. |
Polypeptide variants
|
US6242195B1
(en)
|
1998-04-02 |
2001-06-05 |
Genentech, Inc. |
Methods for determining binding of an analyte to a receptor
|
ES2292236T3
(es)
|
1998-04-02 |
2008-03-01 |
Genentech, Inc. |
Variantes de anticuerpos y sus fragmentos.
|
AU3655899A
(en)
*
|
1998-04-20 |
1999-11-08 |
Regents Of The University Of California, The |
Modified immunoglobulin molecules and methods for use thereof
|
CA2328462C
(en)
|
1998-04-22 |
2010-11-09 |
Genvec, Inc. |
Efficient purification of adenovirus
|
GB9809280D0
(en)
|
1998-04-30 |
1998-07-01 |
Rpms Technology Ltd |
Immunosupression
|
DE19819846B4
(de)
|
1998-05-05 |
2016-11-24 |
Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts |
Multivalente Antikörper-Konstrukte
|
WO1999061630A2
(en)
|
1998-05-26 |
1999-12-02 |
Regeneron Pharmaceuticals, Inc. |
Chimeric molecules comprising an extracellular ligand binding domain of a receptor and an ige fc or constant region, and their use in an assay system
|
US7052872B1
(en)
|
1999-06-22 |
2006-05-30 |
Immunomedics, Inc. |
Bi-specific antibodies for pre-targeting diagnosis and therapy
|
US6818213B1
(en)
|
1998-07-13 |
2004-11-16 |
Board Of Regents, The University Of Texas System |
Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids
|
JP2002520297A
(ja)
|
1998-07-13 |
2002-07-09 |
ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システム |
アミノリン脂質に結合する治療結合体を用いる癌処置方法
|
DK1100830T3
(da)
|
1998-07-28 |
2004-01-19 |
Micromet Ag |
Heterominiantistoffer
|
NZ573838A
(en)
|
1998-08-11 |
2011-01-28 |
Biogen Idec Inc |
Combination therapies for b-cell lymphomas comprising administration of anti-cd20 antibody
|
WO2000011149A1
(en)
|
1998-08-24 |
2000-03-02 |
Uab Research Foundation |
Methods of producing high titer recombinant adeno-associated virus
|
US6472179B2
(en)
|
1998-09-25 |
2002-10-29 |
Regeneron Pharmaceuticals, Inc. |
Receptor based antagonists and methods of making and using
|
US6224866B1
(en)
|
1998-10-07 |
2001-05-01 |
Biocrystal Ltd. |
Immunotherapy of B cell involvement in progression of solid, nonlymphoid tumors
|
AU2472400A
(en)
*
|
1998-10-20 |
2000-05-08 |
City Of Hope |
CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies
|
US6660843B1
(en)
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
US6197294B1
(en)
|
1998-10-26 |
2001-03-06 |
Neurotech S.A. |
Cell surface molecule-induced macrophage activation
|
WO2000027885A1
(fr)
|
1998-11-05 |
2000-05-18 |
Kyowa Hakko Kogyo Co., Ltd. |
Nouveau popypeptide chimerique
|
US7682612B1
(en)
|
1998-11-09 |
2010-03-23 |
Biogen Idec Inc. |
Treatment of hematologic malignancies associated with circulating tumor cells using chimeric anti-CD20 antibody
|
CN1330554A
(zh)
|
1998-11-09 |
2002-01-09 |
Idec药物公司 |
接受bmt或pbsc移植患者的抗cd20嵌合抗体治疗
|
US6380371B1
(en)
|
1998-12-10 |
2002-04-30 |
The Regents Of The University Of California |
Endoglycan: a novel protein having selectin ligand and chemokine presentation activity
|
NZ539776A
(en)
|
1999-01-15 |
2006-12-22 |
Genentech Inc |
Polypeptide variants with altered effector function
|
US6897044B1
(en)
|
1999-01-28 |
2005-05-24 |
Biogen Idec, Inc. |
Production of tetravalent antibodies
|
JP2002536968A
(ja)
|
1999-01-29 |
2002-11-05 |
イムクローン システムズ インコーポレイティド |
Kdrに特異的な抗体およびその使用
|
US6383276B1
(en)
|
1999-03-12 |
2002-05-07 |
Fuji Photo Film Co., Ltd. |
Azomethine compound and oily magenta ink
|
US6383753B1
(en)
|
1999-03-31 |
2002-05-07 |
Regents Of The University Of Michigan |
Yeast mammalian regulators of cell proliferation
|
AU4476600A
(en)
|
1999-04-22 |
2000-11-10 |
Vanderbilt University |
Polymeric encapsulation system promoting angiogenesis
|
GB9909925D0
(en)
*
|
1999-04-29 |
1999-06-30 |
Pharmacia & Upjohn Spa |
Combined preparations comprising anthracycline derivatives
|
US6358596B1
(en)
*
|
1999-04-27 |
2002-03-19 |
The Standard Register Company |
Multi-functional transparent secure marks
|
KR20080039550A
(ko)
|
1999-05-07 |
2008-05-07 |
제넨테크, 인크. |
B 세포 표면 마커에 결합하는 길항물질을 이용한 자가면역질환의 치료
|
US7074403B1
(en)
*
|
1999-06-09 |
2006-07-11 |
Immunomedics, Inc. |
Immunotherapy of autoimmune disorders using antibodies which target B-cells
|
US8119101B2
(en)
|
1999-05-10 |
2012-02-21 |
The Ohio State University |
Anti-CD74 immunoconjugates and methods of use
|
BR0010725A
(pt)
|
1999-05-19 |
2002-02-19 |
Lexigen Pharm Corp |
Expressão e exportação de proteìnas de interferon-alfa como proteìnas de fusão de fc
|
ITMI991299A1
(it)
|
1999-06-11 |
2000-12-11 |
Consiglio Nazionale Ricerche |
Uso di anticorpi contro antigeni di superficie per il trattamento della malattia trapianto contro ospite
|
US6380382B1
(en)
|
1999-06-30 |
2002-04-30 |
Millennium Pharmaceuticals, Inc. |
Gene encoding a protein having diagnostic, preventive, therapeutic, and other uses
|
DE19930748C2
(de)
|
1999-07-02 |
2001-05-17 |
Infineon Technologies Ag |
Verfahren zur Herstellung von EEPROM- und DRAM-Grabenspeicherzellbereichen auf einem Chip
|
CN1373672A
(zh)
|
1999-07-12 |
2002-10-09 |
杰南技术公司 |
应用结合cd20的拮抗剂阻断对外来抗原的免疫应答
|
AU6375000A
(en)
|
1999-07-29 |
2001-02-19 |
Medarex, Inc. |
Human monoclonal antibodies to her2/neu
|
ATE342282T1
(de)
|
1999-07-29 |
2006-11-15 |
Medarex Inc |
Humane monoklonale antikörper gegen prostata spezifisches membranantigen
|
CN1268645C
(zh)
|
1999-07-30 |
2006-08-09 |
米德列斯公司 |
含有抗-fc受体结合剂的治疗化合物
|
US8557244B1
(en)
|
1999-08-11 |
2013-10-15 |
Biogen Idec Inc. |
Treatment of aggressive non-Hodgkins lymphoma with anti-CD20 antibody
|
US6451284B1
(en)
|
1999-08-11 |
2002-09-17 |
Idec Pharmaceuticals Corporation |
Clinical parameters for determining hematologic toxicity prior to radioimmunotheraphy
|
CA2378646A1
(en)
|
1999-08-11 |
2001-02-15 |
Idec Pharmaceuticals Corporation |
Treatment of patients having non-hodgkins lymphoma with bone marrow involvement with anti-cd20 antibodies
|
WO2001013945A1
(en)
|
1999-08-23 |
2001-03-01 |
Biocrystal Ltd. |
Methods and compositions for immunotherapy of b cell involvement in promotion of a disease condition comprising multiple sclerosis
|
ES2219388T3
(es)
|
1999-08-24 |
2004-12-01 |
Ariad Gene Therapeutics, Inc. |
28-epi-rapalogos.
|
US20020028178A1
(en)
|
2000-07-12 |
2002-03-07 |
Nabil Hanna |
Treatment of B cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications
|
CA2390412A1
(en)
|
1999-11-08 |
2001-05-17 |
Idec Pharmaceuticals Corporation |
Treatment of b cell malignancies using anti-cd40l antibodies in combination with anti-cd20 antibodies and/or chemotherapeutics and radiotherapy
|
US20020006404A1
(en)
*
|
1999-11-08 |
2002-01-17 |
Idec Pharmaceuticals Corporation |
Treatment of cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications
|
US6380362B1
(en)
|
1999-12-23 |
2002-04-30 |
Genesis Research & Development Corporation Ltd. |
Polynucleotides, polypeptides expressed by the polynucleotides and methods for their use
|
BR0107939A
(pt)
|
2000-02-25 |
2003-01-28 |
Health Researc Inc |
Processos para medir um analito no corpo de um indivìduo, para extrair fluido extracelular através da pele de um indivìduo e para detectar a presença de um analito no corpo de um indivìduo
|
CA2404390A1
(en)
|
2000-03-24 |
2001-10-04 |
Chiron Corporation |
Methods of therapy for non-hodgkin's lymphoma using a combination of an antibody to cd20 and interleukin-2
|
CA2404365A1
(en)
|
2000-03-31 |
2001-10-11 |
Idec Pharmaceutical Corporation |
Combined use of anti-cytokine antibodies or antagonists and anti-cd20 for the treatment of b cell lymphoma
|
EP1272647B1
(en)
|
2000-04-11 |
2014-11-12 |
Genentech, Inc. |
Multivalent antibodies and uses therefor
|
IL152275A0
(en)
|
2000-04-25 |
2003-05-29 |
Icos Corp |
Inhibitors of human phosphatidyl-inositol 3-kinase delta
|
US6667300B2
(en)
|
2000-04-25 |
2003-12-23 |
Icos Corporation |
Inhibitors of human phosphatidylinositol 3-kinase delta
|
EP1939203B1
(en)
|
2000-04-25 |
2014-11-19 |
ICOS Corporation |
Inhibitors of human phosphatidyl-inositol 3-kinase delta isoform
|
US20020009444A1
(en)
|
2000-04-25 |
2002-01-24 |
Idec Pharmaceuticals Corporation |
Intrathecal administration of rituximab for treatment of central nervous system lymphomas
|
WO2001080883A1
(en)
|
2000-04-26 |
2001-11-01 |
Elusys Therapeutics, Inc. |
Bispecific molecules and uses thereof
|
KR100643818B1
(ko)
|
2000-05-08 |
2006-11-10 |
셀덱스 쎄라퓨틱스, 인크. |
수상세포에 대한 인간 모노클로날 항체
|
US7560534B2
(en)
|
2000-05-08 |
2009-07-14 |
Celldex Research Corporation |
Molecular conjugates comprising human monoclonal antibodies to dendritic cells
|
CA2409991A1
(en)
|
2000-05-24 |
2001-11-29 |
Imclone Systems Incorporated |
Bispecific immunoglobulin-like antigen binding proteins and method of production
|
AU6836301A
(en)
|
2000-06-20 |
2002-01-02 |
Idec Pharma Corp |
Treatment of b-cell associated diseases such as malignancies and autoimmune diseases using a cold anti-cd20 antibody/radiolabeled anti-cd22 antibody combination
|
EP1296714B1
(en)
|
2000-06-22 |
2009-08-26 |
University Of Iowa Research Foundation |
Combination of CpG and antibodies directed against CD19,CD20, CD22 or CD40 for the treatment or prevention of cancer.
|
KR20080074231A
(ko)
|
2000-06-29 |
2008-08-12 |
아보트 러보러터리즈 |
이중 특이성 항체 및 이의 제조 및 사용 방법
|
IL153764A0
(en)
|
2000-07-12 |
2003-07-06 |
Idec Pharma Corp |
Treatment of b cell malignancies using combination of b cell depleting antibody and immune modulating antibody related applications
|
IL152940A0
(en)
|
2000-07-19 |
2003-06-24 |
Orbotech Ltd |
Apparatus and method for electrical testing of electrical circuits
|
US20020025317A1
(en)
|
2000-07-20 |
2002-02-28 |
Schering Ag |
Bispecific monoclonal antibodies to IL-12 and IL-18
|
AU2001282861A1
(en)
|
2000-07-24 |
2002-02-05 |
Florida State University Research Foundation |
Method and apparatus for removal of minute particles from a surface using thermophoresis to prevent particle redeposition
|
DE50112379D1
(de)
|
2000-08-11 |
2007-05-31 |
Univ Ruprecht Karls Heidelberg |
Fv-konstrukte mit beeinflussbarer affinitat zu einer zu bindenden substanz
|
US6946292B2
(en)
|
2000-10-06 |
2005-09-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions with increased antibody dependent cytotoxic activity
|
WO2002034790A1
(en)
|
2000-10-20 |
2002-05-02 |
Idec Pharmaceuticals Corporation |
Variant igg3 rituxan r and therapeutic use thereof
|
NZ527591A
(en)
|
2001-01-17 |
2006-04-28 |
Trubion Pharmaceuticals Inc |
Binding domain-immunoglobulin fusion proteins
|
US20030133939A1
(en)
|
2001-01-17 |
2003-07-17 |
Genecraft, Inc. |
Binding domain-immunoglobulin fusion proteins
|
US7829084B2
(en)
*
|
2001-01-17 |
2010-11-09 |
Trubion Pharmaceuticals, Inc. |
Binding constructs and methods for use thereof
|
US7754208B2
(en)
|
2001-01-17 |
2010-07-13 |
Trubion Pharmaceuticals, Inc. |
Binding domain-immunoglobulin fusion proteins
|
AU2002327164A1
(en)
|
2001-01-29 |
2002-12-09 |
Idec Pharmaceuticals Corporation |
Engineered tetravalent antibodies and methods of use
|
AU2002240120B2
(en)
|
2001-01-29 |
2008-05-08 |
Biogen Idec Inc. |
Modified antibodies and methods of use
|
JP4463475B2
(ja)
|
2001-01-31 |
2010-05-19 |
バイオジェン アイデック インコーポレイテッド |
腫瘍疾患の治療における免疫調節性抗体の使用
|
US7192582B2
(en)
|
2001-02-12 |
2007-03-20 |
Medarex, Inc. |
Human monoclonal antibodies to FC alpha receptor (CD89)
|
WO2002072605A2
(en)
|
2001-03-07 |
2002-09-19 |
Merck Patent Gmbh |
Expression technology for proteins containing a hybrid isotype antibody moiety
|
WO2002072141A2
(en)
|
2001-03-09 |
2002-09-19 |
William Herman |
Targeted ligands
|
EP1383800A4
(en)
|
2001-04-02 |
2004-09-22 |
Idec Pharma Corp |
RECOMBINANT ANTIBODIES CO-EXPRESSED WITH GNTIII
|
CA2440831C
(en)
|
2001-04-02 |
2013-05-28 |
Genentech, Inc. |
Combination therapy using cd40 and cd20 ligands
|
US20040058445A1
(en)
*
|
2001-04-26 |
2004-03-25 |
Ledbetter Jeffrey Alan |
Activation of tumor-reactive lymphocytes via antibodies or genes recognizing CD3 or 4-1BB
|
UA78706C2
(en)
|
2001-06-01 |
2007-04-25 |
Wyeth Corp |
Combination of rapamycin derivative and antitumor alkylating agent and method for treating soft tissue sarcoma and colonic cancer
|
IL159225A0
(en)
|
2001-06-13 |
2004-06-01 |
Genmab As |
Human monoclonal antibodies to epidermal growth factor receptor (egfr)
|
JP2005515161A
(ja)
|
2001-06-14 |
2005-05-26 |
インターミューン インコーポレイテッド |
γ−インターフェロンおよびB細胞特異的抗体の併用療法
|
US20020196854A1
(en)
|
2001-06-15 |
2002-12-26 |
Jongil Kim |
Fast video encoder using adaptive hierarchical video processing in a down-sampled domain
|
US6881557B2
(en)
*
|
2001-07-12 |
2005-04-19 |
Arrowsmith Technologies Llp |
Super humanized antibodies
|
US20030026780A1
(en)
|
2001-07-18 |
2003-02-06 |
Hood Leroy E. |
Innate immunity mediated methods of treating pathological conditions
|
AU2002339863A1
(en)
|
2001-08-31 |
2003-03-18 |
Abmaxis, Inc. |
Multivalent protein conjugate with multiple ligand-binding domains of receptors
|
ATE346866T1
(de)
|
2001-09-14 |
2006-12-15 |
Affimed Therapeutics Ag |
Multimerische, einzelkettige, tandem-fv- antikörper
|
EP1448584B1
(en)
*
|
2001-09-26 |
2010-05-19 |
The Government of the United States of America as represented by The Secretary of Health and Human Services |
Mutated anti-cd22 antibodies with increased affinity to cd22-expressing leukemia cells
|
CA2461631A1
(en)
|
2001-09-28 |
2003-04-03 |
Elusys Therapeutics, Inc. |
Methods and compositions for prevention, diagnosis, and treatment of cancer using bispecific molecules
|
US20030077282A1
(en)
|
2001-10-12 |
2003-04-24 |
Bigler Michael Eric |
Use of bispecific antibodies to regulate immune responses
|
DE10156482A1
(de)
|
2001-11-12 |
2003-05-28 |
Gundram Jung |
Bispezifisches Antikörper-Molekül
|
DE60127143T2
(de)
|
2001-11-14 |
2007-11-15 |
Affimed Therapeutics Ag |
Bispezifische Antikörper gegen CD19 und CD16 und deren Verwendung
|
EP1468097A4
(en)
|
2001-12-26 |
2006-01-11 |
Immunomedics Inc |
PROCESS FOR GENERATING MULTI-QUALITY REAGENTS WITH MULTIPLE SPECIFICITY FROM V SB H / SB AND V SB L / SB DOMAINS
|
WO2003068821A2
(en)
|
2002-02-14 |
2003-08-21 |
Immunomedics, Inc. |
Anti-cd20 antibodies and fusion proteins thereof and methods of use
|
US8361464B2
(en)
|
2002-03-01 |
2013-01-29 |
Immunomedics, Inc. |
Anthracycline-Antibody Conjugates for Cancer Therapy
|
EP1487879B1
(en)
|
2002-03-01 |
2012-12-26 |
Immunomedics, Inc. |
Bispecific antibody point mutations for enhancing rate of clearance
|
US20030219436A1
(en)
|
2002-03-15 |
2003-11-27 |
Ledbetter Jeffrey A. |
Compositions and methods to regulate an immune response using CD83 gene expressed in tumors and using soluble CD83-Ig fusion protein
|
US7332585B2
(en)
|
2002-04-05 |
2008-02-19 |
The Regents Of The California University |
Bispecific single chain Fv antibody molecules and methods of use thereof
|
US7332580B2
(en)
|
2002-04-05 |
2008-02-19 |
The Regents Of The University Of California |
Bispecific single chain Fv antibody molecules and methods of use thereof
|
CA2379586A1
(en)
|
2002-04-10 |
2003-10-10 |
William Herman |
Fluid targeted ligands
|
WO2003091424A1
(fr)
|
2002-04-26 |
2003-11-06 |
Chugai Seiyaku Kabushiki Kaisha |
Procede de criblage d'un anticorps agoniste
|
WO2003106622A2
(en)
|
2002-05-30 |
2003-12-24 |
The Children's Hospital Of Philadelphia |
Methods for treatment of acute lymphocytic leukemia
|
US8034904B2
(en)
|
2002-06-14 |
2011-10-11 |
Immunogen Inc. |
Anti-IGF-I receptor antibody
|
DK1517921T3
(da)
|
2002-06-28 |
2006-10-09 |
Domantis Ltd |
Immunglobulin-enkeltvariable antigen-bindende domæner og dobbeltspecifikke konstruktioner deraf
|
DK1534335T4
(en)
|
2002-08-14 |
2015-10-05 |
Macrogenics Inc |
FCGAMMARIIB-SPECIFIC ANTIBODIES AND PROCEDURES FOR USE THEREOF
|
KR20050065587A
(ko)
|
2002-10-08 |
2005-06-29 |
이뮤노메딕스, 인코오포레이티드 |
항체 치료법
|
RU2349340C2
(ru)
|
2002-10-10 |
2009-03-20 |
Мерк Патент Гмбх |
Биспецифические антитела к erb-b и их применение для лечения опухолей
|
DK2891666T3
(en)
|
2002-10-16 |
2017-10-02 |
Purdue Pharma Lp |
Antibodies that bind cell-associated CA 125 / O722P and methods for its use
|
NZ568769A
(en)
|
2002-10-17 |
2010-04-30 |
Genmab As |
Human monoclonal antibodies against CD20
|
BRPI0316779B8
(pt)
|
2002-12-16 |
2023-02-28 |
Genentech Inc |
Anticorpo anti-cd20 humano ou fragmento de ligação ao antígeno do mesmo, seus usos, composição, artigo manufaturado e formulação líquida
|
WO2004058191A2
(en)
|
2002-12-20 |
2004-07-15 |
Biogen Idec Ma Inc. |
Multivalent lymphotoxin beta receptor agonists and therapeutic uses thereof
|
EP1581171B1
(en)
|
2002-12-20 |
2012-06-27 |
Abbott Biotherapeutics Corp. |
Antibodies against gpr64 and uses thereof
|
PT1576182E
(pt)
*
|
2002-12-23 |
2011-01-21 |
Bristol Myers Squibb Co |
Optimizador da qualidade do produto em processos de cultura celular de mamíferos destinados à produção de proteínas
|
CA2414148A1
(en)
|
2002-12-30 |
2004-06-30 |
William Herman |
Targeted ligands
|
WO2004072266A2
(en)
*
|
2003-02-13 |
2004-08-26 |
Kalobios Inc. |
Antibody affinity engineering by serial epitope-guided complementarity replacement
|
JP3803790B2
(ja)
|
2003-02-17 |
2006-08-02 |
株式会社東北テクノアーチ |
新規なダイアボディ型二重特異性抗体
|
AU2004215489B2
(en)
|
2003-02-25 |
2010-07-15 |
Nykode Therapeutics ASA |
Modified antibody
|
AR044388A1
(es)
|
2003-05-20 |
2005-09-07 |
Applied Molecular Evolution |
Moleculas de union a cd20
|
WO2005021710A2
(en)
|
2003-06-02 |
2005-03-10 |
University Of Miami |
Chimeric molecules and methods of use
|
CN1279056C
(zh)
|
2003-06-06 |
2006-10-11 |
马菁 |
肿瘤相关抗原sm5-1的特异性抗体及其应用
|
JP5068072B2
(ja)
|
2003-06-27 |
2012-11-07 |
バイオジェン・アイデック・エムエイ・インコーポレイテッド |
連結ペプチドを含む改変された結合分子
|
JP5026072B2
(ja)
|
2003-07-01 |
2012-09-12 |
イミューノメディクス、インコーポレイテッド |
二重特異性抗体の多価キャリヤー
|
US6864837B2
(en)
|
2003-07-18 |
2005-03-08 |
Ems Technologies, Inc. |
Vertical electrical downtilt antenna
|
US7754209B2
(en)
*
|
2003-07-26 |
2010-07-13 |
Trubion Pharmaceuticals |
Binding constructs and methods for use thereof
|
CA2536288A1
(en)
|
2003-08-21 |
2005-03-03 |
Kyowa Hakko Kogyo Co., Ltd. |
Cancer metastasis inhibitor
|
AU2004283850C1
(en)
|
2003-10-16 |
2011-11-03 |
Amgen Research (Munich) Gmbh |
Multispecific deimmunized CD3-binders
|
EP1682582B1
(en)
|
2003-11-13 |
2011-08-31 |
Hanmi Holdings Co., Ltd |
Method for the mass production of immunoglobulin constant region
|
BRPI0417107A
(pt)
|
2003-12-19 |
2007-02-06 |
Genentech Inc |
fragmento de anticorpo, métodos de preparação do fragmento de anticorpo, ácido nucléico isolado, composições, célula hospedeira e métodos de fabricação e de geração de fragmento de anticorpo
|
US7235641B2
(en)
|
2003-12-22 |
2007-06-26 |
Micromet Ag |
Bispecific antibodies
|
US20050249723A1
(en)
|
2003-12-22 |
2005-11-10 |
Xencor, Inc. |
Fc polypeptides with novel Fc ligand binding sites
|
MXPA06007174A
(es)
|
2003-12-22 |
2006-08-23 |
Novartis Ag |
Biomarcadores para determinar la sensibilidad de enfermedades proliferativas a inhibidores mtor.
|
US7534604B2
(en)
|
2004-01-16 |
2009-05-19 |
Regeneron Pharmaceuticals, Inc. |
Fusion polypeptides capable of activating receptors
|
ZA200606410B
(en)
|
2004-02-16 |
2007-12-27 |
Micromet Ag |
Less immunogenic binding molecules
|
AR047988A1
(es)
|
2004-03-11 |
2006-03-15 |
Wyeth Corp |
Combinaciones antineoplásicas de cci-779 y rituximab
|
ATE531732T1
(de)
|
2004-03-30 |
2011-11-15 |
Yissum Res Dev Co |
Bi-spezifische antikörper, die auf an reaktionen vom allergischen typ beteiligte zellen zielen, zusammensetzungen und anwendungen davon
|
US7850962B2
(en)
|
2004-04-20 |
2010-12-14 |
Genmab A/S |
Human monoclonal antibodies against CD20
|
US7378504B2
(en)
|
2004-06-03 |
2008-05-27 |
Medarex, Inc. |
Human monoclonal antibodies to Fc gamma receptor I (CD64)
|
AU2005251764A1
(en)
|
2004-06-04 |
2005-12-22 |
Genentech, Inc. |
Method for treating lupus
|
KR20070029733A
(ko)
|
2004-06-04 |
2007-03-14 |
제넨테크, 인크. |
다발성 경화증의 치료 방법
|
US20060008415A1
(en)
|
2004-06-25 |
2006-01-12 |
Protein Design Labs, Inc. |
Stable liquid and lyophilized formulation of proteins
|
EP1786918A4
(en)
|
2004-07-17 |
2009-02-11 |
Imclone Systems Inc |
NEW BISPECIFIC ANTIBODY TETRAVALENT
|
ES2523661T3
(es)
|
2004-07-22 |
2014-11-28 |
Erasmus University Medical Center Rotterdam |
Moléculas de unión
|
CN101124248A
(zh)
|
2004-08-11 |
2008-02-13 |
特鲁比昂药品公司 |
结合域融合蛋白
|
EP1789446A2
(en)
|
2004-09-02 |
2007-05-30 |
Genentech, Inc. |
Heteromultimeric molecules
|
US7393662B2
(en)
|
2004-09-03 |
2008-07-01 |
Centocor, Inc. |
Human EPO mimetic hinge core mimetibodies, compositions, methods and uses
|
KR20070100228A
(ko)
|
2004-10-05 |
2007-10-10 |
제넨테크, 인크. |
혈관염의 치료 방법
|
EP1666500B1
(en)
|
2004-12-01 |
2011-09-21 |
Trion Pharma Gmbh |
Use of trifunctionel antibodies to reduce the risk for GvHD in allogeneic antitumor cell therapy
|
JP2008523083A
(ja)
|
2004-12-08 |
2008-07-03 |
イムノメディクス, インコーポレイテッド |
炎症性疾患および免疫調節不全疾患、感染性疾患、病的血管新生およびがんの免疫療法および検出のための方法および組成物
|
FR2879204B1
(fr)
|
2004-12-15 |
2007-02-16 |
Lab Francais Du Fractionnement |
Anticorps cytotoxique dirige contre les proliferations hematopoietiques lymphoides de type b.
|
WO2006074399A2
(en)
|
2005-01-05 |
2006-07-13 |
Biogen Idec Ma Inc. |
Multispecific binding molecules comprising connecting peptides
|
US8436190B2
(en)
|
2005-01-14 |
2013-05-07 |
Cephalon, Inc. |
Bendamustine pharmaceutical compositions
|
KR100616666B1
(ko)
|
2005-01-27 |
2006-08-28 |
삼성전기주식회사 |
카본나노튜브에 구아니딘기를 형성하는 방법,구아니딘기가 형성된 카본나노튜브를 기판에 부착하는방법 및 이에 따라 제조된 카본나노튜브 및 기판
|
DOP2006000029A
(es)
|
2005-02-07 |
2006-08-15 |
Genentech Inc |
Antibody variants and uses thereof. (variantes de un anticuerpo y usos de las mismas)
|
TWI544076B
(zh)
|
2005-03-31 |
2016-08-01 |
Chugai Pharmaceutical Co Ltd |
A method of manufacturing a polypeptide that controls assembly
|
AR053579A1
(es)
|
2005-04-15 |
2007-05-09 |
Genentech Inc |
Tratamiento de la enfermedad inflamatoria intestinal (eii)
|
US8034902B2
(en)
|
2005-05-04 |
2011-10-11 |
Quark Pharmaceuticals, Inc. |
Recombinant antibodies against CD55 and CD59 and uses thereof
|
US20060263367A1
(en)
|
2005-05-23 |
2006-11-23 |
Fey Georg H |
Bispecific antibody devoid of Fc region and method of treatment using same
|
WO2006130458A2
(en)
|
2005-06-02 |
2006-12-07 |
Astrazeneca Ab |
Antibodies directed to cd20 and uses thereof
|
ES2539250T3
(es)
|
2005-07-25 |
2015-06-29 |
Emergent Product Development Seattle, Llc |
Reducción de células B mediante el uso de moléculas de unión específica a CD37 y de unión específica a CD20
|
KR20080047540A
(ko)
|
2005-07-25 |
2008-05-29 |
트루비온 파마슈티칼스, 인코포레이티드 |
Cd20 특이적 결합 분자의 단회 투여 용도
|
US20080279850A1
(en)
|
2005-07-25 |
2008-11-13 |
Trubion Pharmaceuticals, Inc. |
B-Cell Reduction Using CD37-Specific and CD20-Specific Binding Molecules
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
JP4641476B2
(ja)
|
2005-09-15 |
2011-03-02 |
キヤノン株式会社 |
プローブアレイの製造装置
|
EP1979378B1
(en)
*
|
2005-12-20 |
2012-07-25 |
MorphoSys AG |
Novel collection of hcdr3 regions and uses therefor
|
CA2638794A1
(en)
|
2006-02-15 |
2007-08-23 |
Imclone Systems Incorporated |
Functional antibodies
|
CA3149553C
(en)
*
|
2006-06-12 |
2023-11-21 |
Aptevo Research And Development Llc |
Single-chain multivalent binding proteins with effector function
|
US7846434B2
(en)
|
2006-10-24 |
2010-12-07 |
Trubion Pharmaceuticals, Inc. |
Materials and methods for improved immunoglycoproteins
|
BRPI0717601A2
(pt)
|
2006-10-24 |
2013-10-22 |
Trubion Pharmaceuticals Inc |
Materiais e métodos para imunoglicoproteínas melhoradas
|
CA2682406A1
(en)
|
2007-04-02 |
2008-10-09 |
Genentech, Inc. |
Biological markers predictive of rheumatoid arthritis response to b-cell antagonists
|
WO2008153636A1
(en)
|
2007-05-04 |
2008-12-18 |
Cellsignaling Technology, Inc. |
Phospho-specific antibodies to p13k regulatory subunit and uses thereof
|
WO2008138834A1
(en)
|
2007-05-09 |
2008-11-20 |
Novartis Ag |
Substituted imidazopyridazines as pi3k lipid kinase inhibitors
|
AU2008254951A1
(en)
|
2007-05-14 |
2008-11-27 |
Biogen Idec Ma Inc. |
Single-chain Fc (ScFc) regions, binding polypeptides comprising same, and methods related thereto
|
WO2008152394A1
(en)
|
2007-06-12 |
2008-12-18 |
F.Hoffmann-La Roche Ag |
Pharmaceutical compounds
|
WO2008152387A1
(en)
|
2007-06-12 |
2008-12-18 |
F.Hoffmann-La Roche Ag |
Quinazoline derivatives as pi3 kinase inhibitors
|
WO2008152390A1
(en)
|
2007-06-12 |
2008-12-18 |
F.Hoffmann-La Roche Ag |
Thiazoliopyrimidines and their use as inhibitors of phosphatidylinositol-3 kinase
|
EP2167130A2
(en)
|
2007-07-06 |
2010-03-31 |
Trubion Pharmaceuticals, Inc. |
Binding peptides having a c-terminally disposed specific binding domain
|
PE20120259A1
(es)
|
2007-08-09 |
2012-04-04 |
Boehringer Ingelheim Int |
Anticuerpos anti-cd37
|
AU2008298948B2
(en)
|
2007-09-12 |
2014-09-04 |
F. Hoffmann-La Roche Ag |
Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
|
WO2009039140A1
(en)
|
2007-09-17 |
2009-03-26 |
Smithkline Beecham Corporation |
Pyridopyrimidine derivatives as pi3 kinase inhibitors
|
EP2207781B1
(en)
|
2007-09-24 |
2012-11-28 |
Genentech, Inc. |
Thiazolopyrimidine p13k inhibitor compounds and methods of use
|
WO2009040552A2
(en)
|
2007-09-27 |
2009-04-02 |
Centro Nacional De Investigaciones Oncológicas (Cnio) |
Substituted imidazo (2, 1-b) -1, 3, 4-thiazole compounds, their pharmaceutical compositions and uses thereof
|
GB2467670B
(en)
|
2007-10-04 |
2012-08-01 |
Intellikine Inc |
Chemical entities and therapeutic uses thereof
|
CA2701581C
(en)
|
2007-10-05 |
2016-12-20 |
S*Bio Pte Ltd |
Pyrimidine substituted purine derivatives
|
US20110009403A1
(en)
|
2007-10-05 |
2011-01-13 |
S*Bio Pte Ltd. |
2-morpholinylpurines as inhibitors of pi3k
|
JP2011500702A
(ja)
|
2007-10-16 |
2011-01-06 |
ワイス・エルエルシー |
チエノピリミジンおよびピラゾロピリミジン化合物ならびにmTORキナーゼおよびPI3キナーゼ阻害剤としてのその使用
|
US20100311736A1
(en)
|
2007-10-22 |
2010-12-09 |
Glaxosmithkline Llc |
Pyridosulfonamide derivatives as p13 kinase inhibitors
|
GB0721095D0
(en)
|
2007-10-26 |
2007-12-05 |
Piramed Ltd |
Pharmaceutical compounds
|
ES2537624T3
(es)
|
2007-10-26 |
2015-06-10 |
F. Hoffmann-La Roche Ag |
Derivados purina útiles como inhibidores de la quinasa PI3
|
WO2009059030A1
(en)
|
2007-10-31 |
2009-05-07 |
Burnham Institute For Medical Research |
Pyrazole derivatives as kinase inhibitors
|
US20090131512A1
(en)
|
2007-10-31 |
2009-05-21 |
Dynavax Technologies Corp. |
Inhibition of type I in IFN production
|
SG185996A1
(en)
|
2007-11-13 |
2012-12-28 |
Icos Corp |
Inhibitors of human phosphatidyl-inositol 3-kinase delta
|
WO2009066084A1
(en)
|
2007-11-21 |
2009-05-28 |
F. Hoffmann-La Roche Ag |
2 -morpholinopyrimidines and their use as pi3 kinase inhibitors
|
CN101952285A
(zh)
|
2007-11-27 |
2011-01-19 |
塞尔卓姆有限公司 |
作为pi3k抑制剂的氨基三唑
|
US20090149458A1
(en)
|
2007-11-27 |
2009-06-11 |
Wyeth |
PYRROLO[3,2-d]PYRIMIDINE COMPOUNDS AND THEIR USE AS PI3 KINASE AND mTOR KINASE INHIBITORS
|
US8962803B2
(en)
|
2008-02-29 |
2015-02-24 |
AbbVie Deutschland GmbH & Co. KG |
Antibodies against the RGM A protein and uses thereof
|
SI2132228T1
(sl)
|
2008-04-11 |
2011-10-28 |
Emergent Product Dev Seatle |
CD37 imunoterapevtik in kombinacija z njegovim bifunkcionalnim kemoterapevtikom
|
WO2010057047A1
(en)
*
|
2008-11-13 |
2010-05-20 |
Trubion Pharmaceutics, Inc. |
Cd37 immunotherapeutic combination therapies and uses thereof
|